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EPHA8 Antibody Cat. No.: 13-505 EPHA8 Antibody Specifications HOST SPECIES: Rabbit SPECIES REACTIVITY: Human, Mouse Recombinant fusion protein containing a sequence corresponding to amino acids 28-300 IMMUNOGEN: of human EPHA8 (NP_001006944.1). TESTED APPLICATIONS: WB APPLICATIONS: WB: ,1:1000 - 1:2000 POSITIVE CONTROL: 1) U-87MG 2) B cells 3) Mouse liver 4) Mouse heart 5) Mouse pancreas 6) Mouse brain PREDICTED MOLECULAR Observed: 111kDa WEIGHT: Properties September 29, 2021 1 https://www.prosci-inc.com/epha8-antibody-13-505.html PURIFICATION: Affinity purification CLONALITY: Polyclonal ISOTYPE: IgG CONJUGATE: Unconjugated PHYSICAL STATE: Liquid BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. STORAGE CONDITIONS: Store at -20˚C. Avoid freeze / thaw cycles. Additional Info OFFICIAL SYMBOL: EPHA8 EEK, EK3, HEK3, ephrin type-A receptor 8, EPH- and ELK-related kinase, EPH- and ELK- ALTERNATE NAMES: related tyrosine kinase, EPH-like kinase 3, hydroxyaryl-protein kinase, protein-tyrosine kinase, tyrosine-protein kinase receptor EEK, tyrosylprotein kinase GENE ID: 2046 USER NOTE: Optimal dilutions for each application to be determined by the researcher. Background and References This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich BACKGROUND: domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. September 29, 2021 2 https://www.prosci-inc.com/epha8-antibody-13-505.html.

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Recombinant Human Epha8 Fc Chimera Catalog Number: 6828-A8
Recombinant Human EphA8 Fc Chimera Catalog Number: 6828-A8 DESCRIPTION Source Mouse myeloma cell line, NS0derived Human EphA8 Human IgG (Glu31Thr542) IEGRMD 1 (Pro100Lys330) Accession # NP_065387 Nterminus Cterminus Nterminal Sequence Glu31 Analysis Structure / Form Disulfidelinked homodimer Predicted Molecular 83.2 kDa (monomer) Mass SPECIFICATIONS SDSPAGE 94 kDa, reducing conditions Activity Measured by its binding ability in a functional ELISA. When Recombinant Human EphA8 Fc Chimera is coated at 2 μg/mL (100 μL/well), the concentration of Biotinylayed Recombinant Human EphrinA5 Fc Chimera (Catalog # BT374) that produces 50% of the optimal binding response is 212 ng/mL. Endotoxin Level <0.01 EU per 1 μg of the protein by the LAL method. Purity >90%, by SDSPAGE under reducing conditions and visualized by silver stain. Formulation Supplied as a 0.2 μm filtered solution in MES, NaCl, PEG, CHAPS and Imidazole. See Certificate of Analysis for details. PREPARATION AND STORAGE Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. Stability & Storage Use a manual defrost freezer and avoid repeated freezethaw cycles. l 12 months from date of receipt, 70 °C as supplied. l 1 month, 2 to 8 °C under sterile conditions after opening. l 3 months, 20 to 70 °C under sterile conditions after opening. BACKGROUND EphA8, also known as Hek3 and Eek, is a 120 kDa glycosylated member of the Eph family of transmembrane receptor tyrosine kinases (1, 2). The A and B classes of Eph proteins are distinguished by Ephrin ligand binding preference but have a common structural organization.
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Tyrosine Kinase Panel
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