March 2020 Issue 28 Download

www.gabriel-network.org March 2020 | Issue 28 MEMBERS NEWS Keeping you updated!

In brief

The Mérieux Fondation, has worked closely with Prof. Contents Philippe Vanhems from “Les Hospices Civils de Lyon” ■ In brief and with Prof. Jianwei Wang from the Christophe Mérieux Laboratory, to strengthen the GABRIEL capacity to detect ■ Launch of APRECIT study: Improvement of the and control the SARS-CoV-2 infection. This support consists Management of Tuberculosis of two linked approaches: (i) capacity building and transfer Infection of technology to rapidly implement a SARS-CoV-2 molecular assay, and (ii) a study on the evaluation of the risk of nosocomial ■ Functional Pulmonary Microbiome of Severe transmission of the SARS-CoV-2 for a better knowledge of the Respiratory Tract Infections chains of transmission and the impact of infection, prevention and Risk Assessment and control practices in healthcare settings. ■ European Virus Archive Global A new member joined the GABRIEL network in 2019: the (EVA-GLOBAL) São Paulo Institute of Tropical Medicine (IMT-SP) of the ■ Pneumonia in children under University of São Paulo. This institution will bring new expertise 5 years old: a case-control to the network and will help strengthen the Rodolphe Merieux multicentric study of the Laboratory’s research activities based in Rio Branco, in the GABRIEL network state of Acre, Brazil. ■ Workshop on Molecular and Serological Arbovirus Diagnostics in Dakar

■ GABRIEL member publications since October 2019

The São Paulo Institute of Tropical Medicine (IMT-SP), a specialized institute of the University of São Paulo, is divided into different laboratories with specialized personnel devoted to research and teaching in areas related to tropical diseases.

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In addition, through its link with the Hospital treatment and viral resistance), HPV infection, das Clinicas (HC-FMUSP), the largest respiratory infections, viral phylogeny, central public hospital in Latin America, the IMT- nervous system infections, therapeutic trials SP develops collaborative research with for yellow fever, in addition to other topics. groups in this hospital. IMT-SP operates Researchers at the Virology laboratory are seven laboratories specialized in the studies associated with several international scientific of parasites, bacteria, viruses, and fungi, as networks. well as in the genetics of microorganisms, Cassia Mendez Correa, São Paulo Institute of immunology, and public health. Tropical Medicine, University of São Paulo, Current research is focused on bacterial Brazil resistance (antibiotic-resistant infections and nosocomial infections; Mycobacterium Launch of APRECIT study: Improvement resistance; mechanisms of drug resistance of the Management of Tuberculosis of M. tuberculosis; diagnostic tests for Infection Mycobacterium resistance), Chagas disease biomarker discovery, Leishmania pathogenesis and diagnosis, arbovirus infections; emerging infectious agents; HIV, immunology of fungal infections, blood safety, HTLV, and viral hepatitis.

The Virology laboratory, one of the institute’s seven laboratories, was created in the year 1959 when the IMT-SP was founded. Tuberculosis (TB) comes in two forms, The Virology laboratory has a full range active TB and latent TB. The latter has of equipment and covers a surface area become part of the intervention strategy of approximately 600m2 on two floors. It for TB control programs, supported by has currently directed its research focus recent recommendations from the World towards arboviruses (characterization and Health Organization (WHO). The WHO validation of diagnostic tests for dengue, recommends the early management of zika, chikungunya, yellow fever, and the vulnerable populations (i.e. children under 5 development of cell cultures, conventional years of age and people living with HIV) who serology, real time PCR, sequencing and have had household contact with a case of metagenomics). Also included are infections tuberculosis. These groups are said to be in immunosuppressed patients, viral hepatitis at risk, since the probability of developing (research on hepatitis A, B, C, delta, E and active TB within 6 months to a year after TTV; viral hepatitis co-infection with HIV contact is high. However, the operational and other viruses; diagnosis, pathogenesis, implementation of these recommendations

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presents several issues: 1) access to an 18-month period and will receive a total vulnerable populations in the community, 2) of four home visits for medical follow-up and the latent TB screening strategy, and 3) the for the early identification of subjects who patient’s adherence to latent TB prophylaxis have become symptomatic during the study. that currently lasts 6 months. The results of this operational study will The objective of APRECIT, Amélioration de la make it possible to provide the national TB PRise En Charge de l’Infection Tuberculeuse, control program with recommendations (Improvement of the Management of around diagnostic tools and to improve the Tuberculosis Infection), a study funded by care given to these vulnerable populations. Expertise France and coordinated by the Niana Rakoto, Pasteur Institute of Madagascar Fondation Mérieux (2020-2023), is to provide support to national TB control programs Sara Eyangoh, Pasteur Center of Cameroon in Cameroon and Madagascar for the Jonathan Hoffmann, Laurent Raskine, Mérieux implementation of these recommendations Foundation and, more broadly, for the fight against TB. Functional Pulmonary Microbiome of The Pasteur Center of Cameroon (CPC) and the Pasteur Institute of Madagascar Severe Respiratory Tract Infections and (IPM) will coordinate the project, structured Risk Assessment around community interventions among 2,500 household contacts who have been Acute respiratory infections (ARIs), and identified from 250 index cases of TB patients. particularly pneumonia, are one of the Community officials and clinical research leading causes of mortality, accounting for associates will raise awareness in the more than 4.2 million deaths annually, mainly communities and conduct follow-up surveys affecting children in developing countries like in the homes of these contacts. Medico- Bangladesh. Various studies have reported social staff will be involved in supporting and an alarming rate of morbidity and mortality in monitoring vulnerable populations receiving Bangladesh mostly attributable to pneumonia preventive treatment. and other respiratory infections. Moreover, the economic burden due to respiratory Screening of latent TB will be carried out infections is crippling for many families with a tuberculin skin test (IDR, standard in the country. In recent decades with the test), as well as with two immunological tests development of sequencing technologies, measuring the production of interferon-y lower airways are no longer considered (Interferon gamma release assay): the fully sterile, and a growing amount of QuantiFERON-TB test gold plus and T-Spot evidence indicates that a healthy pulmonary TB. These IGRA tests will be carried out in microbiome can undergo transient changes the National Reference Laboratories for TB, that may impact the progression of respiratory hosted in the CPC and the IPM. All of the diseases. Furthermore, new evidence household contacts will be followed up over points to differences in the microbiome of

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March 2020 | Issue 28 lower airways between healthy subjects Jianwei Wang, Christophe Mérieux Laboratory, and those with respiratory infections and Institute of Pathogen Biology, China diseases. Our study aims to characterize the diversity of pulmonary microbiome in European Virus Archive Global patients with pneumonia and in healthy (EVA-GLOBAL) controls, so as to elucidate the functions of pulmonary microbiome in disease onset and severity. Specimens for this study are to be collected from both enrolled adults and children suffering from pneumonia in two tertiary hospitals in Dhaka. Initially, as based on the signs and symptoms of pneumonia, nasopharyngeal aspirate (NPA) specimens will be collected for pathogen screening by the multiplex real-time PCR technique. EVA-GLOBAL gathers 38 academic Finally, A total of 300 cases (n=100 positive institutions at the forefront of human, animal, cases for each of the pathogens studied, and plant research in virology in association namely, respiratory syncytial virus (RSV), with key non-governmental organisations that influenza virus (IFVs), and Streptococcus include the World Health Organization, OIE, pneumoniae) will be selected for further FAO, and related international organisations, analysis. Corresponding controls (n=80-100) such as the CGIAR (Consultative Group on for each pathogen-positive group will be International Agricultural Research). This recruited. Blood specimens will be collected new international project, created on the from all selected patients. Transcriptomics strong foundations resulting from the two analysis using the deep-sequencing method previous projects, EVA (2009-2014) FP7, will be carried out for the patients along and EVAg (2014-2019) H2020, has been with metabolomics and cytokine profiling. built around high-calibre institutions qualified All information and results obtained will with the appropriate expertise to collect, be transmitted to physicians for diagnosis characterize, standardize, authenticate, and and treatment of participants identified distribute human, animal, and plant viruses. with pneumonia. This study will help to EVA-GLOBAL has been conceived to be elucidate the role of pulmonary microbiome an open-access entity aiming at developing in disease onset and severity in patients with synergies and complementary capabilities in pneumonia caused by influenza viruses, RSV, order to provide researchers with improved or Streptococcus pneumoniae, and will also access to resources. A single-entry point, the provide information on the host or pathogen web-based catalogue, facilitates end-user markers related to disease severity. access to the collections of viruses, derived materials, and engineered cells. This project Firdausi Qadri, Institute for developing will involve 14 facilities specialised in handling Science & Health initiatives, Bangladesh high-risk pathogens (BSL4) to become the

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world’s largest BSL4 network. EVA-GLOBAL Pneumonia in children under 5 years old: will also link up with other global network- a case-control multicentric study of the based virus-associated programmes to create a unique cutting-edge community that GABRIEL network can develop and integrate its activities. The EVA-GLOBAL community aims at becoming the most responsive network able to enhance the surveillance of emerging and re-emerging viral outbreaks at the global level. By the complementarity of its partners in terms of expertise and resources, this advanced community has already played a key role in the control of viral emerging diseases by the supply of unique reagents for the detection of viruses in infected patients. Through this Dr. Cedric Dananché successfully defended new ambitious four-year project and the his PhD thesis on November 20, 2019 new institutions joining the consortium, EVA- Pneumonia remains a public health issue GLOBAL will hold the largest virtual collection in children under 5 years old. In order to of human, animal, and plant viruses, and will study the etiological agents of pneumonia move beyond the current state-of-the-art in this population, a case-control study was to provide increasingly valuable resources carried out between 2010 and 2014 by the and services for the scientific community Global Approach for Biological Research including governmental health departments, on Infectious Epidemics in Low Income higher-education institutes, industries, and Countries (GABRIEL) network in 9 study sites the general public as well. located in 8 low or middle-income countries. The Mérieux Foundation is a partner of The objectives of the present work were to EVA GLOBAL, and two GABRIEL network describe the distribution of Streptococcus members, the GHESKIO center in Haiti and pneumoniae serotypes, to assess the burden the Charles Mérieux Centre of Infectiology in of influenza virus and its effect on the severity Bamako, have joined as associated partners. of pneumonia, and to study virus/bacteria co-detections in nasopharyngeal samples Jean-Louis Romette, University of Marseille, and their effect on the risk of pneumonia. France Results showed that most of S. pneumoniae serotypes detected were included in the pneumococcal 13-Valent conjugate vaccine (PCV13) and confirmed the assumption that the isolate carrying or causing disease in an individual were of the same serotype. The importance of the burden of influenza virus in

March 2020 | Issue 28 pneumonia cases, and particularly A H1N1 The successful diagnosis of arboviruses influenza, was highlighted. Finally, numerous continues to pose serious challenges, and nasopharyngeal co-detections were found the emergence of the Zika virus (ZIKV) in both in pneumonia cases and in control zones where the dengue virus (DENV) is subjects. Pathogenicity of microorganisms endemic has further complicated diagnostic differs between species and might depend testing and interpretation. of the interactions with the microbiome of The main objective of this 5-day course the respiratory tract. Results suggested that was to train participants in molecular and the implementation of PCV13 vaccination serological arbovirus diagnostics and thereby policies might be effective in the study strengthen laboratory capacity in ZIKV/ population. Nevertheless, further studies DENV diagnosis locally. To achieve this aim, focused on the most important co- practical and theoretical sessions have been detections of microorganisms are needed to held to transfer knowledge on quality control improve the understanding of their role in the in a diagnostic laboratory, to understand pathogenesis of pneumonia and to guide the complexity of ZIKV/DENV serology and appropriate public health interventions. the pitfalls within flavivirus serology, and to Cédric Dananché, Health public department, understand the background of the Virus Hospices Civils of Lyon, France Neutralization Assay.

Workshop on Molecular and Serological The next workshop on arbovirus diagnostics will be held in June 2020 in Sao Paulo in Arbovirus Diagnostics in Dakar partnership with the Institute of Tropical Medicine of the Sao Paulo University.

Florence Pradel, Mérieux Foundation, France

GABRIEL member publications since October 2019

Epidemiology of Cholera in Bangladesh: Findings From Nationwide Hospital-based Surveillance, 2014-2018. Khan AI, Rashid MM, Islam MT, Afrad MH, Salimuzzaman M, Hegde ST, Zion MMI, Khan Thanks to the ZikaPLAN project funded by ZH, Shirin T, Habib ZH, Khan IA, Begum YA, Azman the EU, scientists and technicians working AS, Rahman M, Clemens JD, Flora MS, Qadri F. Clin Infect Dis. 2019 Dec 31. pii: ciz1075. doi: 10.1093/ on arbovirus projects in Senegal and West cid/ciz1075. Africa attended a workshop organized by the Mérieux Foundation and Institut Pasteur Augmented immune responses to a booster dose of Dakar from January 6-10, 2020. Both of oral cholera vaccine in Bangladeshi children less are members of ZikaPLAN’s Platform for than 5 years of age: Revaccination after an interval of over three years of primary vaccination with a single Diagnostics Innovation and Evaluation. dose of vaccine. Chowdhury F, Bhuiyan TR, Akter A,

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Bhuiyan MS, Khan AI, Tauheed I, Ahmed T, Ferdous J, correlates with protection against Helicobacter pylori Dash P, Basher SR, Hakim A, Lynch J, Kim JH, Excler infection in immunized mice.Akter S, Jeverstam F, JL, Kim DR, Clemens JD, Qadri F. Vaccine. 2019 Dec Lundgren A, Magnusson MK, Walduck A, Qadri 23. pii: S0264-410X(19)31676-7. doi: 10.1016/j. F, Bhuiyan TR, Raghavan S. Helicobacter. 2019 vaccine.2019.12.034. [Epub ahead of print] Dec;24(6):e12658. doi: 10.1111/hel.12658. Epub 2019 Sep 9. Safety and immunogenicity of the oral, inactivated, enterotoxigenic Escherichia coli vaccine ETVAX in Isolation, Purification, Characterization and Direct Bangladeshi children and infants: a double-blind, Conjugation of the Lipid A-Free Lipopolysaccharide randomised, placebo-controlled phase 1/2 trial. of Vibrio cholerae O139. Xu P, Korcová J, Baráth P, Qadri F, Akhtar M, Bhuiyan TR, Chowdhury MI, Čížová A, Valáriková J, Qadri F, Kelly M, O’Connor Ahmed T, Rafique TA, Khan A, Rahman SIA, Khanam RD, Ryan ET, Bystrický S, Kováč P. Chemistry. F, Lundgren A, Wiklund G, Kaim J, Löfstrand M, 2019 Oct 8;25(56):12946-12956. doi: 10.1002/ Carlin N, Bourgeois AL, Maier N, Fix A, Wierzba chem.201902263 T, Walker RI, Svennerholm AM.Lancet Infect Dis. 2020 Feb;20(2):208-219. doi: 10.1016/S1473- Identification of Widespread Antibiotic Exposure 3099(19)30571-7. Epub 2019 Nov 19. in Patients With Cholera Correlates With Clinically Relevant Microbiota Changes. Alexandrova L, Conservation and global distribution of non-canonical Haque F, Rodriguez P, Marrazzo AC, Grembi JA, antigens in Enterotoxigenic Escherichia coli. Kuhlmann Ramachandran V, Hryckowian AJ, Adams CM, FM, Martin J, Hazen TH, Vickers TJ, Pashos M, Siddique MSA, Khan AI, Qadri F, Andrews JR, Okhuysen PC, Gómez-Duarte OG, Cebelinski E, Rahman M, Spormann AM, Schoolnik GK, Chien A, Boxrud D, Del Canto F, Vidal R, Qadri F, Mitreva M, Nelson EJ. J Infect Dis. 2019 Oct 8;220(10):1655- Rasko DA, Fleckenstein JM. PLoS Negl Trop Dis. 1666. doi: 10.1093/infdis/jiz299. 2019 Nov 22;13(11):e0007825. doi: 10.1371/journal. pntd.0007825. eCollection 2019 Nov. Endothelial B2-receptor overexpression as an alternative animal model for hereditary angioedema. Immune responses to O-specific polysaccharide Veronez CL, Maghsodi S, Todiras M, Popova E, (OSP) in North American adults infected with Vibrio Rodrigues AF, Qadri F, Pesquero JB, Bader M. Allergy. cholerae O1 Inaba. Hossain M, Islam K, Kelly M, 2019 Oct;74(10):1998-2002. doi: 10.1111/all.13836. Mayo Smith LM, Charles RC, Weil AA, Bhuiyan TR, Epub 2019 Jun 28. Kováč P, Xu P, Calderwood SB, Simon JK, Chen WH, Lock M, Lyon CE, Kirkpatrick BD, Cohen M, Evaluation of the safety and immunogenicity of the oral Levine MM, Gurwith M, Leung DT, Azman AS, Harris inactivated multivalent enterotoxigenic Escherichia JB, Qadri F, Ryan ET. PLoS Negl Trop Dis. 2019 coli vaccine ETVAX in Bangladeshi adults in a double- Nov 19;13(11):e0007874. doi: 10.1371/journal. blind, randomized, placebo-controlled Phase I trial pntd.0007874. eCollection 2019 Nov. using electrochemiluminescence and ELISA assays for immunogenicity analyses. Akhtar M, Chowdhury Atp6ap2 deletion causes extensive vacuolation that MI, Bhuiyan TR, Kaim J, Ahmed T, Rafique TA, consumes the insulin content of pancreatic cells. Khan A, Rahman SIA, Khanam F, Begum YA, Sharif Binger KJ, Neukam M, Tattikota SG, Qadri F, Puchkov MZ, Islam LN, Carlin N, Maier N, Fix A, Wierzba TF, D, Willmes DM, Wurmsee S, Geisberger S, Dechend Walker RI, Bourgeois AL, Svennerholm AM, Qadri F, R, Raile K, Kurth T, Nguyen G, Poy MN, Solimena Lundgren A. Vaccine. 2019 Sep 3;37(37):5645-5656. M, Muller DN, Birkenfeld AL. Proc Natl Acad Sci U S doi: 10.1016/j.vaccine.2018.11.040. Epub 2018 Nov A. 2019 Oct 1;116(40):19983-19988. doi: 10.1073/ 22. pnas.1903678116. Epub 2019 Sep 16. Comparative Performance of Modified Kenneth The frequency of circulating integrin 47+ cells Jones Criteria Scoring, World Health Organization

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Criteria, and Antibodies in Lymphocyte Supernatant print] for Diagnosing Tuberculosis in Severely Malnourished Children Presenting With Pneumonia. Chisti MJ, HEV study protocol : design of a cluster-randomised, Shahid ASMSB, Shahunja KM, Banu S, Raqib R, blinded trial to assess the safety, immunogenicity Shahrin L, Islam SB, Sharifuzzaman, Saha H, Alam T, and effectiveness of the hepatitis E vaccine HEV Rahman MW, Nuzhat S, Afroze F, Sarmin M, Ahmed 239 (Hecolin) in women of childbearing age in rural T. Front Pediatr. 2019 Oct 1;7:406. doi: 10.3389/ Bangladesh. Zaman K, Dudman S, Stene-Johansen fped.2019.00406. eCollection 2019 K, Qadri F, Yunus M, Sandbu S, Gurley ES, Overbo J, Julin CH, Dembinski JL, Nahar Q, Rahman A, Identification of a systemic interferon-inducible Bhuiyan TR, Rahman M, Haque W, Khan J, Aziz antimicrobial gene signature in leprosy patients A, Khanam M, Streatfield PK, Clemens JD.BMJ undergoing reversal reaction.Teles RMB, Lu J, Tió- Open. 2020 Jan 19;10(1):e033702. doi: 10.1136/ Coma M, Goulart IMB, Banu S, Hagge D, Bobosha bmjopen-2019-033702. K, Ottenhoff THM, Pellegrini M, Geluk A, Modlin RL, 2019. PLoS Negl Trop Dis 10;13(10):e0007764. Nationwide carrier detection and molecular characterization of -thalassemia and hemoglobin E Whole blood RNA signatures in leprosy patients variants in Bangladeshi population. Noor FA, Sultana identify reversal reactions before clinical onset: a N, Bhuyan GS, Islam MT, Hossain M, Sarker SK, prospective, multicenter study. Tió-Coma M, van Islam K, Khan WA, Rahman M, Qadri SK, Shekhar Hooij A, Bobosha K, van der Ploeg-van JJ, Banu S, HU, Qadri F, Qadri SS, Mannoor K. Orphanet J Rare Khadge S, Thapa P, Kunwar CB, Goulart IM, Bekele Dis. 2020 Jan 15;15(1):15. doi: 10.1186/s13023- Y, 2019. Scientific Reports 9: 1-12. 020-1294-z.

A public-private model to scale up diabetes mellitus Genetic Characterization of Plasmid-Borne bla OXA- screening among people accessing tuberculosis 58 in Distinct Acinetobacter Species. Matos, Adriana diagnostics in Dhaka, Bangladesh. Paul KK, Alkabab P. ; Cayô, Rodrigo ; Almeida, Luiz G. P. ; Streling, YMA, Rahman MM, Ahmed S, Amin MJ, Hossain Ana Paula ; Nodari, Carolina S. ; MARTINS, Willames MD, Heysell SK, Banu S. Int J Infect Dis. 2020 Jan M. B. S. ; Narciso, Ana Clara ; Silva, Rosa M. ; 8;92:56-61. doi: 10.1016/j.ijid.2020.01.001. Vasconcelos, Ana T. R. ; Gales, Ana C. mSphere, v. 4, p. 1-8, 2019. High-Dose Neonatal Vitamin A Supplementation Transiently Decreases Thymic Function in Early Staphylococcus aureus Small Colony Variants (SCVs): Infancy. Ahmad SM, Raqib R, Huda MN, Alam MJ, News From a Chronic Prosthetic Joint Infection. Loss, Monirujjaman M, Akhter T, Wagatsuma Y, Qadri Guilherme ; Simões, Patricia Martins ; Valour, Florent F, Zerofsky MS, Stephensen CB. J Nutr. 2020 Jan ; Cortês, Marina Farrel ; Gonzaga, Luiz ; Bergot, 1;150(1):176-183. doi: 10.1093/jn/nxz193. Marine ; Trouillet-Assant, Sophie ; Josse, Jêrome ; Diot, Alan ; Ricci, Emiliano ; Vasconcelos, Ana Tereza Re-evaluating herd protection by Vi typhoid vaccine ; Laurent, Frédéric. Frontiers in Cellular and Infection in a cluster randomized trial. Ali M, Sur D, Kanungo Microbiology, v. 9, p. 1-12, 2019. S, Qadri F, Kim DR, Islam T, Im J, Ahmmed F, Chon Y, Khan AI, Zaman K, Marks F, Dutta S, Bhattacharya Dental pain among psychoactive substance users in SK, Clemens JD. Int Health. 2020 Jan 1;12(1):36-42. CAPS AD in Vitoria, Vila Velha and Serra, ES, Brazil. doi: 10.1093/inthealth/ihz069. Lorencini BV, Bissoli BC, Simões JC, Miotto MHMB, Siqueira MM, Zandonade E. Cien Saude Colet. Can we ‘WaSH’ infectious diseases out of slums? 2019 Oct 28;24(11):4093-4102. doi: 10.1590/1413- Ross AG, Rahman M, Alam M, Zaman K, Qadri F. Int 812320182411.29582017. eCollection 2019. J Infect Dis. 2020 Jan 18. pii: S1201-9712(20)30016- Portuguese. 3. doi: 10.1016/j.ijid.2020.01.014. [Epub ahead of

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An Inexpensive and Accurate Reverse Transcription- 2016, Bonath Ka, Martine Valette, Monidarin Chou and PCR-Melting Temperature Analysis Assay for Real- Bruno Lina. Journal of Infectious Diseases & Therapy, Time Influenza Virus B Lineage Discrimination. Motta 2019, 7:6 DOI: 10.41722332-0877.1000413 FC, Born PS, Resende PC, Brown D, Siqueira MM. J Clin Microbiol. 2019 Nov 22;57(12). pii: e00602-19. A Treatment-Decision Score for HIV-Infected Children doi: 10.1128/JCM.00602-19. Print 2019 Dec. With Suspected Tuberculosis. Marcy O, Borand L, Ung V, Msellati P, Tejiokem M, Huu KT, Do Chau V, Quantum Chemical-Guided Steglich Rearrangement Ngoc Tran D, Ateba-Ndongo F, Tetang-Ndiang S, of Azlactones and Isoxazolones. De Castro PP, Nacro B, Sanogo B, Neou L, Goyet S, Dim B, Pean P, Dos Santos JA, De Siqueira MM, Batista GMF, Quillet C, Fournier I, Berteloot L, Carcelain G, Godreuil Dos Santos HF, Amarante GW. J Org Chem. 2019 S, Blanche S, Delacourt C; ANRS 12229 PAANTHER Oct 4;84(19):12573-12582. doi: 10.1021/acs. 01 STUDY GROUP. Pediatrics. 2019 Sep;144(3). pii: joc.9b02099. Epub 2019 Sep 26. e20182065. doi: 10.1542/peds.2018-2065

Inherited IFNAR1 deficiency in otherwise healthy Is resistance to direct-acting antivirals in sub-Saharan patients with adverse reaction to measles and yellow Africa a threat to HCV elimination? Recommenda- fever live vaccines. Hernandez N, Bucciol G, Moens tions for action. Gupta N, Kateera F, Desalegn H, L, Le Pen J, Shahrooei M, Goudouris E, Shirkani A, Ocama P, Njouom R, Lacombe K. J Hepatol. 2019 Changi-Ashtiani M, Rokni-Zadeh H, Sayar EH, Reisli Dec 10:S0168-8278(19)30644-0. I, Lefevre-Utile A, Zijlmans D, Jurado A, Pholien R, Drutman S, Belkaya S, Cobat A, Boudewijns R, Global burden of hepatitis B infection in people living Jochmans D, Neyts J, Seeleuthner Y, Lorenzo- with HIV: a systematic review and meta-analysis. Diaz L, Enemchukwu C, Tietjen I, Hoffmann HH, Leumi S, Bigna JJ, Amougou MA, Ngouo A, Nyaga Momenilandi M, Pöyhönen L, Siqueira MM, de Lima UF, Noubiap JJ. Clin Infect Dis. 2019 Dec 9:ciz1170. SMB, de Souza Matos DC, Homma A, Maia MLS, da Costa Barros TA, de Oliveira PMN, Mesquita EC, Model-based cost-effectiveness estimates of testing Gijsbers R, Zhang SY, Seligman SJ, Abel L, Hertzog strategies for diagnosing hepatitis C virus infection in P, Marr N, Martins RM, Meyts I, Zhang Q, MacDonald people who use in-jecting drugs in Senegal. Duchesne MR, Rice CM, Casanova JL, Jouanguy E, Bossuyt L, Hejblum G, Toure Kane NC, Njouom R, Toni T-Da, X. J Exp Med. 2019 Sep 2;216(9):2057-2070. doi: Moh R, Sylla B, Rouveau N, Attia A, Lacombe K. Int J 10.1084/jem.20182295. Epub 2019 Jul 3. Drug Policy. 2019 Nov 28 ;75:102613-.

Etiology, clinical, and epidemiological characteristics The epidemiology of hepatitis delta virus infection of severe respiratory infection in people living with in Cameroon. Besombes C, Njouom R, Paireau J, HIV. Pecego AC, Amâncio RT, Costa DM, Bozza FA, Lachenal G, Texier G, Tejiokem M, Cauchemez S, Pépin Siqueira MM, Oliveira ML, Cerbino-Neto J, Japiassu J, Fontanet A. Gut. 2020 Jan 6;gutjnl-2019-320027. A. Int J STD AIDS. 2020 Jan 22:956462419882587. doi: 10.1136/gutjnl-2019-320027. [Epub ahead of doi: 10.1177/0956462419882587. print]. PMID: 31907297.

Hepatitis B: Prevalence and occult infection in HIV- Phylogenetic varia-bility of Human Metapneumovirus infected patients. Calux SJ, Silva VCM, Compri AP, in patients with acute respiratory infections in Lemos MF, Santos APT, Oba IT, Mendes-Correa Cameroon, 2011-2014. Kenmoe S, Vernet MA, MCJ, Moreira RC. Rev Soc Bras Med Trop. 2020 Jan Penlap Beng V, Vabret A, Njouom R. J Infect Public 27;53:e20180533. doi: 10.1590/0037-8682-0533- Health. 2019 Sep 14. pii: S1876-0341(19) 30298-9. 2018. eCollection 2020. doi: 10.1016/j.jiph.2019.08.018

Characterization of influenza viruses responsible for The epidemiological signa-ture of influenza B virus acute respiratory illness in Cambodia from 2015 to and its B/Victoria and B/Yamagata lineages in the 21st

March 2020 | Issue 28 century. Saverio Caini ,Gabriela Kusznierz, Verònica doi: 10.1371/journal.pntd.0007797. Vera Garate, Sonam Wangchuk, Binay Thapa, Francisco José de Paula Júnior, Walquiria Aparecida Dog demographics and husbandry practices related Ferreira de Almeida, Richard Njouom, Rodrigo A. with rabies in Cameroon. Bouli FPNO, Awah-Ndukum Fasce, Patricia Bustos, Luzhao Feng, Zhibin Peng, J, Mingoas KJ, Tejiokem MC, Tchoumboue J. Trop Jenny Lara Araya, [ ... ], the Global Influenza B Study Anim Health Prod. 2019 Nov 18. doi: 10.1007/ team . PLoS One. 2019 Sep 12;14(9):e0222381. doi: s11250-019-02085-9. 10.1371/ journal.pone.0222381. eCollection 2019. Circulation of influenza virus from 2009 to 2018 in Dengue virus infection in people residing in Africa: a Came-roon: 10 years of surveillance data. Njouom R, systematic review and meta-analysis of prevalence Monamele CG, Munshili Njifon HL, Kenmoe S, Ripa studies. Simo FBN, Bigna JJ, Kenmoe S, Ndangang Njankouo M, Network of influenza surveillance. PLoS MS, Temfack E, Moundipa PF, Demanou M. Sci Rep. One. 2019 Dec 3;14(12):e0225793-e. 2019 Sep 20;9(1):13626. doi: 10.1038/s41598-019- 50135-x. Case-control study of the immune status of hu-mans infected with zoonotic gorilla simian foamy viruses. Overview of rabies post-exposure prophylaxis Gessain A, Montange T, Betsem E, Ndongo CB, access, procurement and distribution in selected Njouom R, Buseyne F. J Infect Dis. 2019:jiz660. countries in Asia and Africa, 2017-2018. Vaccine. Sreenivasan N, Li A, Shiferaw M, Tran CH, Wallace Hospital-based Surveillance Provides Insights Into R, Blanton J, Knopf L, Abela- Ridder B, Hyde T; the Etiology of Pediatric Bacterial Men-ingitis in Working group on Rabies PEP logistics. 2019 Aug Yaounde , Cameroon, in the Post-Vaccine Era. 27. pii: S0264-410X(19)30475- X. doi: 10.1016/j. Boula A, Senghore M, Ngoh R, Tassadjo F, Fonkoua vaccine.2019.04.024 MC, Nzouankeu A, Njiki MK, Musi J, Bebey S, Ngo Baleba M, Nkembe A, Me djina S, Ndow PS, Worwui Molecular characterization of measles virus strains A, Kobela M, Nimpa M, Mwenda JM, N’diaye A, circulating in Cameroon during the 2013-2016 Kwambana-Adams BA, Antonio M. Clin Infect Dis. epidemics. Franck-Martin Obam Mekanda, Chavely 2019 Sep 5;69(Supplement_2):S148-S155. doi: Gwladys Monamele, Fredy Brice Simo Nemg, Gilde 10.1093/cid/ciz506. Martial Yonga, Diane Ouapi, Veronique Penlap Beng, Christophe Batejat, Valerie Caro, Jean- K-13 propeller gene polymor-phisms isolated between Claude Manuguerra, Maurice Demanou. https://doi. 2014 and 2017 from Cameroonian Plasmodium org/10.1371/ journal.pone.0222428 falcipa-rum malaria patients. Eboumbou Moukoko CE, Huang F, Nsango SE, Kojom Foko LP, Ebong Overview of rabies post-exposure prophylaxis SB, Epee Eboumbou P, Yan H, Sitchueng L, Garke access, procurement and distribution in selected B, Ayong L. PLoS One. 2019 Sep 3;14(9):e0221895. countries in Asia and Africa, 2017-2018. Sreenivasan doi: 10.1371/ journal.pone.0221895. eCollection N, Li A, Shiferaw M, Tran CH, Wallace R, Blanton J, 2019 Knopf L, Abela-Ridder B, Hyde T; Working group on Rabies PEP logistics (Dr Tejiokem). Vaccine. A systematic review on anti-malarial drug discovery 2019 Oct 3;37 Suppl 1:A6-A13. doi: 10.1016/j. and antiplasmodial poten-tial of green synthesis vaccine.2019.04.024. Epub 2019 Aug 27. mediated metal nanoparticles: overview, challenges and future perspectives. Kojom Foko LP, Eya’ane Genetic and phenotypic charac-terization of recently Meva F, Eboumbou Mouko-ko CE, Ntoumba AA, discovered enterovirus D type 111. Sadeuh-Mba SA, Ngaha Njila MI, Belle Ebanda Kedi P, Ayong L, Joffret ML, Mazitchi A, Endegue-Zanga MC, Njouom Lehman LG. Malar J. 2019 Oct 3;18(1):337. doi: R, Delpeyroux F, Gouandjika-Vasilache I, Bessaud M. 10.1186/s12936-019-2974-9. PLoS Negl Trop Dis. 2019 Oct 17;13(10):e0007797.

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Occurrence of 30 trace elements in foods from a multi- Yi Hu, Li Zhang, Guohui Fan, Jiuyang Xu, Xiaoying centre Sub-Saharan Afri-ca Total Diet Study: Focus Gu, Zhenshun Cheng, Ting Yu, Jiaan Xia, Yuan on Al, As, Cd, Hg, and Pb. Jitarua P, Ingenbleek L, Wei, Wenjuan Wu, Xuelei Xie, Wen Yin, Hui Li, Min Marchond N, Laurent C, Adeg-boye A, Hossou SE, Liu, Yan Xiao, Hong Gao, Li Guo, Jungang Xie, Zié Koné A, Oyedele AD, Sika K.J. Kisito C, Koreissi Guangfa Wang, Rongmeng Jiang, Zhancheng Gao, Dembélé Y, Eyangoh S, Verger P, Le Bizec B, Leblanc Qi Jin, Jianwei Wang†, Bin Cao. Lancet. 2020 Feb JC, Guérin T. Africa Total Diet Study. Environ Int. 2019 15;395(10223):497-506. doi: 10.1016/S0140- Dec 24 ;135:105413-. 6736(20)30183-5. Epub 2020 Jan 24

Le-vels of persistent organic pollutants (POPs) in foods Full spectrum of COVID-19 severity still being depicted from the first regional Sub-Saharan Africa Total Diet – Author’s reply. Gu X, Cao B, Wang J. Lancet. 2020 Study. Vaccher V, Ingenbleek L, Adegboye A, Hossou Feb 14. pii: S0140-6736(20)30371-8. SE, Koné AZ, Oyedele AD, Kisito CSKJ, Dembélé YK, Hu R, Adbel Malak I, Cariou R, Vénisseau A, Veyrand Crimean-Congo hemorrhagic fever virus replication B, Marchand P, Eyangoh S, Verger P, Dervilly-Pinel G, imposes hyper-lipidation of MAP1LC3 in epithelial Leblanc J-C, Le Bizec B. Environ Int. 2019 Dec 24 cells. Moroso M, Verlhac P, Ferraris O, Rozières A, ;135:105413-. Carbonnelle C, Mély S, Endtz HP, Peyrefitte CN, Paranhos-Baccalà G, Viret C, Faure M. Autophagy. 2020 Daily and event-driven pre-exposure prophylaxis for Jan 8:1-13. doi: 10.1080/15548627.2019.1709765. men who have sex with men in Belgium: results of a prospec-tive cohort measuring adherence, sexual Rates and Risk Factors for Nephrotoxicity and behaviour and STI incidence. Vuylsteke B, Reyniers Ototoxicity Among Tuberculosis Patients in Tbilisi, T, De Baetselier I, Nöstlinger C, Crucitti T, Buyze J, Georgia. M Buziashvili , V Mirtskhulava , M Kipiani , Kenyon C, Wouters K, Laga M. J Int AIDS Soc. 2019 H M Blumberg, D Baliashvili, M J Magee, J J Furin, N Oct;22(10):e25407. doi: 10.1002/jia2.25407. Tukvadze , R R Kempker . Int J Tuberc Lung Dis, 23 (9), 1005-1011, 2019 Sep. Strengthening timely detection and reporting of unusual respiratory events from health facilities in Classifying Recurrent Mycobacterium Tuberculosis Yaoundé, Cameroon. Alroy KA, Gwom LC, Ndongo Cases in Georgia Using MIRU-VNTR Typing. Nino CB, Kenmoe S, Monamele G, Clara A, Whitaker B, Maghradze, Levan Jugheli , Sonia Borrell, Nestani Manga H, Tayimetha CY, Tseuko D, Etogo B, Pasi Tukvadze, Rusudan Aspindzelashvili, Zaza Avaliani, O, Etoundi AG, Seukap E, Njouom R, Balajee A. Klaus Reither, Sebastien Gagneux. PLoS One, 14 Influenza Other Respir Viruses. 2020 Jan 10;10.1111/ (10), e0223610, 2019 Oct 18 eCollection 2019. irv.12684. doi: 10.1111/irv.12684. [Epub ahead of print]. PMID: 31923349. The FANMI («my FAMILY» in Creole) study to evaluate community-based cohort care for adolescent and Identification of a novel coronavirus causing severe young women living with HIV in Haiti: protocol for pneumonia in human: a descriptive study. Ren LL, a randomized controlled trial. Seo G, Joseph JMB, Wang YM, Wu ZQ, Xiang ZC, Guo L, Xu T, Jiang YZ, Confident N, Jean E, Louis B, Bell T, Riche RC, Xiong Y, Li YJ, Li XW, Li H, Fan GH, Gu XY, Xiao Y, Belizaire ME, Rouzier V, Apollon A, Reif L, Rivera Gao H, Xu JY, Yang F, Wang XM, Wu C, Chen L, Liu V, Abrams E, Bang H, Schackman B, Fitzgerald D, YW, Liu B, Yang J, Wang XR, Dong J, Li L, Huang CL, Pape JW, McNairy ML. BMC Public Health. 2019 Dec Zhao JP, Hu Y, Cheng ZS, Liu LL, Qian ZH, Qin C, Jin 30;19(1):1749. doi: 10.1186/s12889-019-8065-6. Q, Cao B, Wang JW. Chin Med J (Engl). 2020 Feb 11. Diagnostic yield of active case finding for tuberculosis Clinical features of patients infected with 2019 at human immunodeficiency virus testing in Haiti. noval coronavirus in Wuhan, China. Chaolin Huang, Rivera VR, Lu L, Ocheretina O, Jean Juste MA, Yeming Wang, Xingwang Li, Lili Ren, Jianping Zhao, Julma P, Archange D, Moise CG, Homeus F, Phanor

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PD, Petión S, Cremieux PY, Fitzgerald DW, Pape Sugandhavesa P, Montalban E, Avihingsanon A, JW, Koenig SP. Int J Tuberc Lung Dis. 2019 Nov Santos BR, Kumarasamy N, Kanyama C, Schooley 1;23(11):1217-1222. doi: 10.5588/ijtld.18.0835. RT, Mellors JW, Wallis CL, Collier AC; A5288 Team. Lancet HIV. 2019 Sep 6. doi: 10.1016/S2352- The Population Impact of Late Presentation with 3018(19)30146-8. Epub 2019 Jul 29. Advanced HIV Disease and Delayed Antiretroviral Therapy in Adults Receiving HIV Care in Latin America. Necessary but not Sufficient: The Need for Innovative Belaunzarán-Zamudio PF, Caro-Vega YN, Shepherd Strategies to Enhance Retention and Viral Suppression BE, Rebeiro PF, Crabtree-Ramírez BE, Cortes CP, after Rapid Initiation of Antiretroviral Therapy. Clinical Grinsztejn B, Gotuzzo E, Mejia F, Padgett D, Pape Infectious Diseases. 2019 Dec 7. ciz1176, https://doi. JW, Rouzier V, Veloso V, Cardoso SW, McGowan CC, org/10.1093/cid/ciz1176. Serena Patricia Koenig. Sierra-Madero JG. Am J Epidemiol. 2019 Oct 29. pii: kwz252. doi: 10.1093/aje/kwz252. Perceptions of isolation during facility births in Haiti - a qualitative study. Dev A, Kivland C, Faustin M, Turnier Increased Mortality after Tuberculosis Treatment O, Bell T, Leger MD. Reprod Health. 2019 Dec 27; Completion in Persons with HIV in Latin America. 16(1):185. doi: 10.1186/s12978-019-0843-1. Koenig SP, Kim A, Shepherd BE, Cesar C, Veloso V, Cortes CP, Padgett D, Crabtree-Ramírez B, Effectiveness of various communication strategies for Gotuzzo E, McGowan CC, Sterling TR, Pape JW; improving childhood pneumonia case management: Caribbean, Central and South America Network for a community based behavioral open labeled trial in HIV Epidemiology (CCASAnet). Clin Infect Dis. 2019 rural Lucknow, Uttar Pradesh, India. Awasthi S, et al. Oct 20. pii: ciz1032. doi: 10.1093/cid/ciz1032. [Epub BMC Public Health 2019. PMID 31870334. ahead of print] Effect of Different Doses of Inhaled Corticosteroids on «FANMI»: A Promising Differentiated Model of HIV the Isolation of Nasopharyngeal Flora in Children with Care for Adolescents in Haiti. Reif LK, Rivera VR, Asthma. Nirmal G, et al. Indian Pediatr 2019. Among Bertrand R, Belizaire ME, Joseph JB, Louis B, Joseph authors: Awasthi S. PMID 31729320. B, Anglade B, Seo G, Severe P, Rouzier V, Pape JW, Fitzgerald DW, McNairy ML. J Acquir Immune Defic Micronutrient-fortified infant cereal improves Syndr. 2019 Sep 1;82(1):e11-e13. doi: 10.1097/QAI. hemoglobin status and reduces iron deficiency anemia in Indian infants: An effectiveness study. Psychological distress among a population- Awasthi S, et al. Br J Nutr 2020. PMID 31896356 representative sample of residents of four slum neighborhoods in Port-au-Prince, Haiti. Tymejczyk In-vitro evaluation of the antibacterial activity of the O, Rivera VR, Peck M, Dorélien A, Petion JS, Seo essential oils of Micromeria barbata, Eucalyptus G, Walsh KF, Pape JW, McNAIRY ML, Fitzgerald DW, globulus and Juniperus excelsa against strains Nash D, Parcesepe A. J Affect Disord. 2020 Feb of Mycobacterium tuberculosis (including MDR), 15;263:241-245. doi: 10.1016/j.jad.2019.11.103. Mycobacterium kansasii and Mycobacterium Epub 2019 Nov 23. gordonae. El Omari K, Hamze M, Alwan S, Osman M, Jama C, Chihib NE. J Infect Public Health. 2019 Sep - Third-line antiretroviral therapy in low-income Oct;12(5):615-618. doi: 10.1016/j.jiph.2019.01.058. and middle-income countries (ACTG A5288): a Epub 2019 Feb 6. prospective strategy study. Grinsztejn B, Hughes MD, Ritz J, Salata R, Mugyenyi P, Hogg E, Wieclaw Advances in understanding and managing L, Gross R, Godfrey C, Cardoso SW, Bukuru A, Scedosporium respiratory infections in patients with Makanga M, Faesen S, Mave V, Wangari Ndege B, cystic fibrosis. Bouchara JP, Le Govic Y, Kabbara Nerette Fontain S, Samaneka W, Secours R, van S, Cimon B, Zouhair R, Hamze M, Papon N, Nevez Schalkwyk M, Mngqibisa R, Mohapi L, Valencia J, G. Expert Rev Respir Med. 2019 Dec 23:1-15. doi:

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10.1080/17476348.2020.1705787. [Epub ahead of and call for action. Maalouf FT, Alamiri B, Atweh print] S, Becker AE, Cheour M, Darwish H, Ghandour LA, Ghuloum S, Hamze M, Karam E, Khoury B, Impact of human sequences in variable domains of Khoury SJ, Mokdad A, Meho LI, Okasha T, Reed therapeutic antibodies on the location of CD4 T-cell GM, Sbaity E, Zeinoun P, Akl EA. Lancet Psychiatry. epitopes. Meunier S, Hamze M, Karle A, de Bourayne 2019 Nov;6(11):961-966. doi: 10.1016/S2215- M, Gdoura A, Spindeldreher S, Maillère B. Cell Mol 0366(19)30124-5. Epub 2019 Jul 18. Review. Immunol. 2019 Oct 28. doi: 10.1038/s41423-019- 0304-3. [Epub ahead of print] No abstract available. Molecular epidemiology of Campylobacter isolates from broiler slaughterhouses in Tripoli, North of Migratory DCs activate TGF- to precondition naïve Lebanon. Rafei R, Al Kassaa I, Osman M, Dabboussi CD8+ T cells for tissue-resident memory fate. Mani F, Hamze M. Br Poult Sci. 2019 Dec;60(6):675-682. V, Bromley SK, Äijö T, Mora-Buch R, Carrizosa E, doi: 10.1080/00071668.2019.1645945. Epub 2019 Warner RD, Hamze M, Sen DR, Chasse AY, Lorant Jul 31. A, Griffith JW, Rahimi RA, McEntee CP, Jeffrey KL, Marangoni F, Travis MA, Lacy-Hulbert A, Luster AD, Prevalence and genetic diversity of Campylobacter Mempel TR. Science. 2019 Oct 11;366(6462). pii: spp. in the production chain of broiler chickens eaav5728. doi: 10.1126/science.aav5728. in Lebanon and its association with the intestinal protozoan Blastocystis sp. Greige S, Rivoal K, Osman Plasmid-mediated quinolone resistance: Mechanisms, M, Safadi DE, Dabboussi F, Hage RE, Viscogliosi detection, and epidemiology in the Arab countries. E, Hamze M, Chemaly M. Poult Sci. 2019 Nov Yassine I, Rafei R, Osman M, Mallat H, Dabboussi F, 1;98(11):5883-5891. doi: 10.3382/ps/pez286. Hamze M. Infect Genet Evol. 2019 Dec;76:104020. doi: 10.1016/j.meegid.2019.104020. Epub 2019 Zoonotic tuberculosis in humans assessed by next- Sep 4. generation sequencing: an 18-month nationwide study in Lebanon. El Achkar S, Demanche C, Osman Emergence of clinical mcr-1-positive Escherichia coli M, Rafei R, Ismail MB, Gaudin C, Duthoy S, De in Lebanon. Al-Mir H, Osman M, Azar N, Madec JY, Matos F, Yaacoub H, Pinçon C, Hamze M, Supply Hamze M, Haenni M. J Glob Antimicrob Resist. 2019 P. Eur Respir J. 2020 Jan 2;55(1). pii: 1900513. doi: Dec;19:83-84. doi: 10.1016/j.jgar.2019.08.019. 10.1183/13993003.00513-2019. Print 2020 Jan. Epub 2019 Sep 4. No abstract available. Recent trends in the epidemiology, diagnosis, The epidemiology of Candida species in the Middle treatment, and mechanisms of resistance in clinical East and North Africa. Ghazi S, Rafei R, Osman M, El Aspergillus species: A general review with a special Safadi D, Mallat H, Papon N, Dabboussi F, Bouchara focus on the Middle Eastern and North African JP, Hamze M. J Mycol Med. 2019 Sep;29(3):245- region. Zakaria A, Osman M, Dabboussi F, Rafei R, 252. doi: 10.1016/j.mycmed.2019.07.006. Epub Mallat H, Papon N, Bouchara JP, Hamze M. J Infect 2019 Jul 26. Public Health. 2020 Jan;13(1):1-10. doi: 10.1016/j. jiph.2019.08.007. Epub 2019 Oct 28. Review. LABiocin database: A new database designed specifically for Lactic Acid Bacteria bacteriocins. Cytokinin Sensing in Bacteria. Kabbara S, Bidon B, Kassaa IA, Rafei R, Moukhtar M, Zaylaa M, Gharsallaoui Kilani J, Osman M, Hamze M, Stock AM, Papon A, Asehraou A, Omari KE, Shahin A, Hamze M, Chihib N. Biomolecules. 2020 Jan 25;10(2). pii: E186. doi: NE. Int J Antimicrob Agents. 2019 Dec;54(6):771- 10.3390/biom10020186. 779. doi: 10.1016/j.ijantimicag.2019.07.012. Epub 2019 Jul 30. Qishta-A Lebanese Heat Concentrated Dairy Product Characteristics and Production Procedures. Najib M, Mental health research in the Arab region: challenges Hallab MW, Hallab K, Hallab Z, Delaplace G, Hamze

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M, Chihib NE. Foods. 2020 Jan 24;9(2). pii: E125. treatment response in Trypanosoma cruzi infected doi: 10.3390/foods9020125. children: A 12-months follow-up study in Bolivia. Vásquez Velásquez C, Russomando G, Espínola Stepwise evolution and convergent recombination EE, Sanchez Z, Mochizuki K, Roca Y, Revollo J underlie the global dissemination of carbapenemase- Guzman A, Quiroga B, Rios Morgan S, Vargas Ortiz producing Escherichia coli. Patiño-Navarrete R, R, Zambrana Ortega A, Espinoza E, Nishizawa JE, Rosinski-Chupin I, Cabanel N, Gauthier L, Takissian Kamel MG, Kikuchi M, Mizukami S, Na-Bangchang J, Madec JY, Hamze M, Bonnin RA, Naas T, Glaser P. K, Tien Huy N, Hirayama K. PLoS Negl Trop Dis. Genome Med. 2020 Jan 20;12(1):10. doi: 10.1186/ 2019 Sep 25;13(9):e0007715. doi: 10.1371/journal. s13073-019-0699-6. pntd.0007715. eCollection 2019 Sep.

First characterization of methanogens in oral cavity The GABRIEL network receives support in Malian patients with oral cavity pathologies. from bioMérieux and Bioaster. Sogodogo E, Doumbo O, Aboudharam G, Kouriba B, Diawara O, Koita H, Togora S, Drancourt M. BMC Oral Health. 2019 Oct 30;19(1):232. doi: 10.1186/ s12903-019-0929-8.

The Diagnosis of Fungal Neglected Tropical Diseases (Fungal NTDs) and the Role of Investigation and Laboratory Tests: An Expert Consensus Report. Hay R, Denning DW, Bonifaz A, Queiroz-Telles F, Beer K, Bustamante B, et al. Trop Med Infect Dis. 2019 Sep 24;4(4).

Sporotrichosis in the Highlands of Madagascar, 2013– 20171. Rasamoelina T, Maubon D, Raharolahy O, Razanakoto H, Rakotozandrindrainy N, Rakotomalala FA, et al. Emerg Infect Dis. 2019 Oct;25(10):1893– 902.

Epidemiological characteristics of cryptococcal meningoencephalitis associated with Cryptococcus neoformans var. grubii from HIV-infected patients in Madagascar: A cross-sectional study. Rakotoarivelo RA, Raberahona M, Rasamoelina T, Rabezanahary A, Rakotomalala FA, Razafinambinintsoa T, et al. PLOS Neglected Tropical Diseases. 2020 Jan 13;14(1):e0007984.

Positive Interference of Hemolysis on Kaliemia Dosage Corresponding to Hemolysis Degree on Bs 300. Ranaivosoa MK, Rakotoniaina T, Rahajanirina V, Rasamoelina T, Randriamanantany ZA, Alson OR, et al. Journal of Biotechnology and Biomedicine. 2020 Jan 16;3(1):10–6.

IL-17A, a possible biomarker for the evaluation of

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