Osteophyte Formation Involves PAR2

Total Page：16

File Type：pdf, Size：1020Kb

RESEARCH HIGHLIGHTS Nature Reviews Rheumatology | Published online 22 Jan 2016; doi:10.1038/nrrheum.2016.6 OSTEOARTHRITIS Osteophyte formation involves PAR2 Osteophytes, or bony spurs, are mineral density. Intra-articular bone outgrowths that form early injection of human PAR2-expressing fewer Par2-/- in osteoarthritis (OA) in an adenoviruses reversed the phenotype -/- mice developed attempt to compensate for joint of Par2 mice to control levels, damage. Huesa et al. now show that confirming that Par2 deletion is the osteophytes ... proteinase-activated receptor 2 causative factor. Histological analysis compared with (PAR2) is involved in this process, of the osteophytes in control mice control mice thereby expanding the known roles revealed the presence of proliferative of PAR2 in OA beyond cartilage and hypertrophic chondrocytes that degradation and osteosclerosis. expressed PAR2. Given that PAR2 is PAR2, a G protein-coupled not normally expressed in cartilage, receptor, might be involved in OA the authors concluded that expression through its role in modulating the of PAR2 in osteophytes is pathological. expression of metalloproteases. Carl Goodyear (co-corresponding Systemic inactivation of Par2 in author) also explains that they mice (Par2-/- mice) was previously used dynamic weight-bearing as a found to slow OA progression. surrogate indicator of pain, which is “In this study, we have a novel approach in OA models. integrated a cross-disciplinary range Par2-/- mice placed more weight on of techniques to allow an holistic the affected limb than controls, approach to elucidating early joint suggesting impaired nociception. changes in OA,” states John Lockhart, Taken together, these results co-corresponding author on this demonstrate that PAR2 is not only paper. Micro-CT showed that fewer involved in OA progression, but also Par2-/- mice developed osteophytes regulates early osteophyte formation 4 weeks after induction of OA via its presence in chondrocytes. through destabilization of the medial Moving forward, the authors will meniscus compared with control focus on the role of osteophyte mice; when osteophytes developed, formation in OA, a process that is they were smaller and had a greater not yet well understood. “Our work with PAR2 provides a means by which this process can be Osteophyte interrogated,” claims Lockhart. Liesbet Lieben, Associate Editor Nature Reviews Disease Primers PAR2 Chondrocyte ORIGINAL ARTICLE Huesa, C. et al. NPG Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology. Ann. Rheum. Dis. http://dx.doi.org/10.1136/ Bone annrheumdis-2015-208268 Nature Reviews | Rheumatology NATURE REVIEWS | RHEUMATOLOGY www.nature.com/nrrheum © 2016 Macmillan Publishers Limited. All rights reserved.

Copy Link

Recommended publications

The Characteristics of Osteophyte Around Lumbar Vertebral Foramina Associated with Spinal Stenosis
Original Article https://doi.org/10.5115/acb.2019.52.2.143 pISSN 2093-3665 eISSN 2093-3673 The characteristics of osteophyte around lumbar vertebral foramina associated with spinal stenosis Thawanthorn Chaimongkhol1, Atiphoom Thiamkaew1, Pasuk Mahakkanukrauh2,3,4 1Faculty of Medicine, Chiang Mai University, Chiang Mai, 2Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 3Forensic Osteology Research Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 4Excellence Center in Osteology Research and Training Center (ORTC), Chiang Mai University, Chiang Mai, Thailand Abstract: Spinal stenosis most commonly occurs on lumbar vertebrae because of degenerative changes. This research studied the characteristics of osteophyte development in lumbar vertebrae foramina and association of osteophyte development with lumbar spinal stenosis. The total number of all levels of lumbar spines of subjects was 179 from 31 to 90 years of age. The vertebral foramen was divided into six zones. The prevalence and measurements of the length of osteophytes in the vertebral foramina were obtained. The prevalence and length of osteophytes in the posterior body zone were higher than the laminal zone, and higher than the pedicular zone, respectively. In each zone, the highest prevalence of osteophytes was at L5, except for the inferior posterior body zone that the highest prevalence is at L4. The length of osteophyte was also in same direction as the prevalence. The prevalence of osteophytes among six zones of each level were compared, and found, in L1 to L4, the inferior posterior body zone generally had the highest prevalence, except in L5, the superior posterior body zone had the highest prevalence.
[Show full text]
Coblation Versus Traditional Tonsillectomy
Global Journal of Otolaryngology ISSN 2474-7556 Case Report Glob J Otolaryngol Volume 6 Issue 4 - April 2017 Copyright © All rights are reserved by Cristina. Otilia Laza DOI: 10.19080/GJO.2017.06.555695 Dysphagia in Forestier Syndrome Cristina Otilia Laza* and Mostafa Sarv ENT Clinic SCJU, SF APOSTOL ANDREI ‘’, Constanta, Romania Submission: April 06, 2017; Published: April 17, 2017 *Corresponding author: Cristina. Otilia Laza, Professor associate PhD –ENT -head and neck surgery, ENT/OMF Clinic, SCJU SF “APOSTOL ANDREI “ Constanta, B-dul Tomis, 145,8700, Constanta, Romania, Email: Abstract Dysphagia is a frequent complaint in elderly patients. At this age, neurological and tumoral causes predominates. Diffuse idiopathic spine.skeletal Most hyperostosis patients are (DISH), free ofalso symptoms, known as so Forestier that DISH disease is usually , first discovered described fortuitouslyin1950 by J. uponForestier, plain is radiographs a rare cause of of the dysphagia spine obtained ,caused forby large calcification along the anterior and lateral sides of the vertebral bodies, produces the appearance of candle wax dripping down the evaluation for dysphagia in an old patient. The diagnosis requires imaging but also other causes especially tumors must be excluded. another reason. A few patients experience spinal pain, spinal stiffness, or dysphagia. We report a case in which the diagnosis was made upon Keywords: Dysphagia; Retropharyngeal; Prevertebral space; Diffuse idiopathic skeletal hyperostosis (DISH); Forestier syndrome Case Report A 69-year-old man with was referred to our Laboratory Tests dl) with a normal ferritin level. Erythrocyte sedimentation rate otorhinolaryngology clinic for difficulties in swallowing solid His full blood count showed a normocytic anaemia (9.32 g/ he was capable to swallow very soft pureed foods or liquids.
[Show full text]
Osteophyte and Enthesophyte Formation Are Positively Associated
Annals of the Rheumatic Diseases 1997;56:85–90 85 Ann Rheum Dis: first published as 10.1136/ard.56.2.85 on 1 February 1997. Downloaded from EXTENDED REPORTS Bone formers: osteophyte and enthesophyte formation are positively associated Juliet Rogers, Lee Shepstone, Paul Dieppe Abstract phenomenon, unrelated to any joint disease.4 Objective—To test the hypothesis that New bone can form at individual entheses in enthesophyte formation and osteophyte response to a seronegative spondarthritis.5 growth are positively associated and to More commonly, they are seen in several sites look for associations between bone forma- as part of the condition ﬁrst described in the tion at diVerent sites on the skeleton so spine by Forrestier and Rotes-Querol6 and now that a simple measure of bone formation known as diVuse idiopathic skeletal hyperost- could be derived. osis (DISH).7 Methods—Visual examination of 337 adult The presence of periarticular osteophytes skeletons. All common sites of either has been noted by Resnick and Niwayama in enthesophyte or osteophyte formation DISH1 but the relation of enthesophyte and were inspected by a single observer who marginal osteophytosis in this condition has graded bone formation at these sites on a not been speciﬁcally investigated. This study 0-3 scale. The total score for each feature tests the hypothesis that some individuals have was divided by the number of sites exam- a greater tendency to form bone at both joint ined to derive an enthesophyte and an margins and entheses than others. The osteophyte score. Cronbach’s á and hypothesis has been derived from the observa- principal components analysis were used tion in skeletal studies of striking osteophyte to identify groupings.
[Show full text]
Facet Arthropathy Evaluation: CT Or MRI?
European Radiology (2019) 29:4990–4998 https://doi.org/10.1007/s00330-019-06047-5 MUSCULOSKELETAL Facet arthropathy evaluation: CT or MRI? Linda Berg1,2 & Hanne Thoresen1 & Gesche Neckelmann3 & Håvard Furunes4,5,6 & Christian Hellum 7 & Ansgar Espeland3,8 Received: 29 August 2018 /Revised: 31 December 2018 /Accepted: 25 January 2019 /Published online: 22 February 2019 # European Society of Radiology 2019 Abstract Objective To assess the reliability of lumbar facet arthropathy evaluation with computed tomography (CT) or magnetic reso- nance imaging (MRI) in patients with and without lumbar disc prosthesis and to estimate the reliability for individual CT and MRI findings indicating facet arthropathy. Methods Metal-artifact reducing CT and MRI protocols were performed at follow-up of 114 chronic back pain patients treated with (n = 66) or without (n = 48) lumbar disc prosthesis. Three experienced radiologists independently rated facet joint space narrowing, osteophyte/hypertrophy, erosions, subchondral cysts, and total grade facet arthropathy at each of the three lower lumbar levels on both CT and MRI, using Weishaupt et al’s rating system. CT and MRI examinations were randomly mixed and rated independently. Findings were dichotomized before analysis. Overall kappa and (due to low prevalence) prevalence- and bias-adjusted kappa were calculated to assess interobserver agreement. Results Interobserver agreement on total grade facet arthropathy was moderate at all levels with CT (kappa 0.47–0.48) and poor to fair with MRI (kappa 0.20–0.32). Mean prevalence- and bias-adjusted kappa was lower for osteophyte/hypertrophy versus other individual findings (CT 0.58 versus 0.79–0.86, MRI 0.35 versus 0.81–0.90), higher with CT versus MRI when rating osteophyte/hypertrophy (0.58 versus 0.35) and total grade facet arthropathy (0.54 versus 0.31), and generally similar at levels with versus levels without disc prosthesis.
[Show full text]
Characterisation of Size and Direction of Osteophyte in Knee Osteoarthritis: a Radiographic Study Y Nagaosa, P Lanyon, M Doherty
319 EXTENDED REPORT Ann Rheum Dis: first published as 10.1136/ard.61.4.319 on 1 April 2002. Downloaded from Characterisation of size and direction of osteophyte in knee osteoarthritis: a radiographic study Y Nagaosa, P Lanyon, M Doherty ............................................................................................................................. Ann Rheum Dis 2002;61:319–324 Objectives: To examine the size and direction of osteophyte in knee osteoarthritis (OA) and to deter- mine associations between osteophyte size and other radiographic features. Methods: Knee radiographs (standing extended anteroposterior and 30 degrees flexion skyline views) were examined from 204 patients referred to hospital with symptomatic knee OA (155 women, 49 men; mean age 70, range 34–91 years). A single observer assessed films for osteophyte size and direction at eight sites; narrowing in each compartment; varus/valgus angulation; patellofemoral sub- luxation; attrition; and chondrocalcinosis using a standard atlas, direct measurement, or visual assess- ment. For analysis, one OA knee was selected at random from each subject. Results: Osteophyte direction at the eight sites was divisible into five categories. At all sites, except for See end of article for the lateral tibial plateau and the medial patella, osteophyte direction varied according to (a) the size authors’ affiliations of osteophyte and (b) the degree of local narrowing. At the medial femur, medial tibia, and lateral ....................... femur osteophyte direction changed from being predominantly horizontal to predominantly vertical Correspondence to: with increasing size. The size of osteophyte correlated positively with the severity of local narrowing, Professor M Doherty, except for the medial patellofemoral compartment where osteophyte size correlated positively with the Academic Rheumatology, severity of narrowing in the medial tibiofemoral compartment.
[Show full text]
Factors Affecting the Onset and Progression of Rotator Cuff Tears in the General Population
www.nature.com/scientificreports OPEN Factors afecting the onset and progression of rotator cuf tears in the general population Tsuyoshi Ichinose1, Hitoshi Shitara1*, Tsuyoshi Tajika1, Tsutomu Kobayashi2, Atsushi Yamamoto3, Noritaka Hamano1, Tsuyoshi Sasaki1, Daisuke Shimoyama1, Masataka Kamiyama1, Ryosuke Miyamoto1, Kenji Takagishi4 & Hirotaka Chikuda1 While previous studies have revealed factors afecting the progression of rotator cuf tear (RCT), none have yet described factors afecting its onset. The purpose of this longitudinal observational study was to analyze factors afecting the RCT onset and progression in the general population. The present study included 185 shoulders from 93 participants who completed all the examinations in both 2012 and 2017. Participants received a questionnaire with age, gender, arm dominance, and presence of pain at rest, in motion, and at night. The range of motion (ROM), simple shoulder test (SST) were also examined. Anteroposterior radiograph of the shoulder joint was performed to evaluate the degree of osteoarthritic changes by the Samilson-Prieto (S-P) classifcation. The degree of RCT was examined by ultrasonography. There were 132 shoulders without RCT and 53 with RCT in 2012. RCT occurred in 21 of 132 shoulders, and the factor afecting the RCT onset was S-P grade 2 osteoarthritic change in 2012 (odds ratio [OR] 10.10). RCT progressed in 22 of 53 shoulders, and the factor afecting RCT progression was the presence of motion pain in 2012 (OR 13.76). These results added new knowledge regarding the natural course of RCT onset and progression. A degenerative rotator cuf tear (RCT) is a common shoulder disorder in the elderly1. Previous studies have assumed that age1,2, sex3, smoking4,5, and posture6 caused RCT.
[Show full text]
Cervical Spondylosis, Stenosis, and Rheumatoid Arthritis
Cervical Spondylosis, Stenosis, and Rheumatoid Arthritis Matthew McDonnell, MD, and Phillip Lucas, MD CERVI ca L SPONYLOSIS /STENOSIS The uncovertebral joints hypertrophy, Clinical Presentations Cervical spondylosis is common and which may lead to foraminal stenosis. The Axial Neck Pain progresses with increasing age. It is the posterior zygoapophyseal joints can also Neck pain is an extremely common result of degenerative changes in the cer- become arthritic, causing foraminal nar- but nonspecific presenting symptom. vical spine, including disc degeneration, rowing. The ligamentum flavum thickens It is often associated with stiffness and facet arthropathy, osteophyte formation, and sometimes buckles as a result of the headaches. The pain or soreness is usu- ligamentous thickening and loss of cervi- loss of disk height. These degenerative ally in the paramedian neck muscles cal lordosis. Spinal stenosis, or narrowing changes can result in cervical stenosis with posteriorly, with radiation toward the of the spinal canal, may occur as a result spinal cord compression. Concomitant occiput or into the shoulder, arm and of progression of spondylotic changes. straightening of cervical lordosis (or even periscapular regions. The referred pain Spinal cord or nerve root function may kyphosis), disk herniations or protru- does not follow a dermatomal distribu- be affected, resulting in symptoms of sions often may accentuate the problem tion. Deep palpation of some of these myelopathy or radiculopathy. because the spinal cord will be stretched areas results in reproducible patterns of over the posterior aspect of the disks and referred pain. Determining the source Natural History and Epidemiology vertebral bodies. of neck pain can be a diagnostic chal- Spinal cord compression resulting Cervical spondylosis will typically lenge.
[Show full text]
Osteophytes in the Osteoarthritic Hand: Their Incidence, Size, Distribution, and Progression
Annals ofthe Rheumatic Disases 1991; 50: 627-630 627 Ann Rheum Dis: first published as 10.1136/ard.50.9.627 on 1 September 1991. Downloaded from Osteophytes in the osteoarthritic hand: their incidence, size, distribution, and progression J C Buckland-Wright, D G Macfarlane, J A Lynch Abstract osteophytes at the marginal and capsular sites of Quantitative microfocal radiographic assess- each joint in wrists and hands. Progression in ment of osteophytes in osteoarthritic hands the number and area of osteophytes was showed that their number and area were assessed and their distribution in the wrist and greatest at joint margins, in the dominant hand with time was studied. hand, in the second and third compared with fourth and fifth phalanges, in the third phalanx, and in the second distal inter- Patients and methods phalangeal joint respectively. These sites cor- Forty five patients were recruited, of whom 32 respond with those for the largest forces (three male, 29 female; mean age at first visit 62 exerted in the hand: the dominant side, the (SD 10) years; mean disease duration 11-6 (SD finger tripod used in the precision grip, power 10) years) completed the full 18 months of the grip, and pulp-pinch respectively. The greater study. All had evidence of two of the three osteophytosis on the trapezium of the non- following features in the hands on conventional dominant first carpometacarpal joint was radiography: subchondral sclerosis, joint space probably related to forces exerted during narrowing, and osteophytes. Sixteen patients power grip. Osteophytes increased signifi- had interphalangeal nodes on entry, defined as canty in number and area during the 18 one visible swelling on one joint plus three or month study period.
[Show full text]
The Relationship Between Neural Foraminal Stenosis and Imaging Features of Lumbar Spine MRI in Patients Older Than 60 Years With
J Korean Soc Radiol 2021;82(4):862-875 Original Article https://doi.org/10.3348/jksr.2020.0095 eISSN 2288-2928 Received May 15, 2020 Revised September 1, 2020 Accepted October 6, 2020 The Relationship between *Corresponding author Hee Seok Jeong, MD Department of Radiology, Neural Foraminal Stenosis Pusan National University Yangsan Hospital, 20 Geumo-ro, Mulgeum-eup, and Imaging Features Yangsan 50612, Korea. Tel 82-55-360-1845 Fax 82-55-360-1848 of Lumbar Spine MRI in E-mail [email protected] This is an Open Access article distributed under the terms of Patients Older Than 60 Years the Creative Commons Attribu- tion Non-Commercial License (https://creativecommons.org/ with Lumbar Radiculopathy licenses/by-nc/4.0) which permits unrestricted non-commercial 요추신경근병증이 있는 60세 이상의 환자에서 신경공 use, distribution, and reproduc- tion in any medium, provided the 협착과 자기공명영상 평가를 통한 인자와의 상관관계 original work is properly cited. 1 1 1 Kyeyoung Lee, MD , Hee Seok Jeong, MD * , Chankue Park, MD , 1 1 1 Maeran Kim, MD , Hwaseong Ryu, MD , Jieun Roh, MD , ORCID iDs 1 1 Jeong A Yeom, MD , Jin Hyeok Kim, MD , Kyeyoung Lee 1 2 https:// Tae Un Kim, MD , Chang Ho Jeon, MD orcid.org/0000-0003-0468-2005 1 Department of Radiology, Pusan National University Yangsan Hospital, Yangsan, Korea Hee Seok Jeong 2 https:// Department of Radiology, Pusan National University Hospital, Busan, Korea orcid.org/0000-0002-8459-1260 Chankue Park https:// orcid.org/0000-0003-2937-114X Maeran Kim Purpose To investigate the MRI features associated with neural foraminal stenosis (NFS) in pa- https:// tients older than 60 years with lumbar (L) radiculopathy.
[Show full text]
Disk Degeneration in Lumbar Spine Precedes Osteoarthritic Changes in Hip
An Original Study Disk Degeneration in Lumbar Spine Precedes Osteoarthritic Changes in Hip Navkirat S. Bajwa, BS, Jason O. Toy, MD, Ernest Y. Young, BS, Daniel R. Cooperman, MD, and Nicholas U. Ahn, MD that come with advancing age: shrinkage and loss of cartilage Abstract space, and osteophyte formation caused by degeneration.1-3 It is not clear whether spinal degeneration leads Analysis of the impact of OA on the spine and hip raises to hip arthritis, or hip arthritis leads to spinal de- several questions: (1) What is the relationship between hip generation. We conducted a study to determine OA and lumbar DDD? (2) Do OA changes in one region pre- which degenerative process precedes the other. cede degenerative changes in the other? (3) How does the We examined 340 cadaveric human speci- incidence of hip OA and spine OA increase progressively with mens from the Hamann-Todd Osteological age? The relationship between hip and spine degeneration was Collection (Cleveland, Ohio). Lumbar endplate first described by Offierski and MacNab.4 It was hypothesized degeneration was graded on a scale of 0 to 4, that degeneration in one area could lead to decompensation and hip degeneration on a scale of 0 to 3. Linear in the other; however, which precedes the other is unclear. regression was used to analyze the relationship Answering these questions could lead to effective methods of between hip osteoarthritis (OA) and lumbar de- diagnosing and preventing OA and slowing its progression. generative disk disease (DDD). Exact tests were We studied a large number of skeletal specimens to ob- used to identify differences in each age group.
[Show full text]
Bone Protrusion That We Should Be Aware Of: Foraminal Osteophytes; Classification and Surgical Results
DOI: 10.4274/haseki.4310 Med Bull Haseki 2018;56:299-306 Bone Protrusion That We Should be Aware of: Foraminal Osteophytes; Classification and Surgical Results Farkında Olmamız Gereken Kemik Çıkıntı: Foraminal Osteofitler; Sınıflama ve Cerrahi Sonuçlar Ahmet Öğrenci Neurospinal Academy, Neurosurgery, İstanbul, Turkey Abstract Öz Aim: The aim is to report our surgical results and techniques and Amaç: Amaç lomber foraminal osteofitlerde cerrahi sonuçları ve to establish a common classification system for lumbar foraminal tekniği paylaşıp, ortak bir sınıflama oluşturmak ve tedavi algoritması osteophytes. belirlemektir. Methods:Thirty-six patients who underwent surgery at our institution Yöntemler:Opere ettiğimiz 36 hasta çalışmaya dahil edildi. Radiküler were included. Because of the presence of radicular pain in these ağrıları olan ve lomber manyetik rezonans görüntülemede foraminal patients, after magnetic resonance imaging, computed tomography stenozu olan hastalara lomber bilgisayarlı tomografi (BT) çekimi yapıldı. (CT) of the lumbar spine was performed to confirm foraminal stenosis. Osteofit formasyonuna bağlı foraminal stenozu olan ve tarafımızca Osteophytes were classified using CT images in patients with findings buna bağlı olarak ameliyat edilen hastalarda BT görüntüleri kullanılarak of foraminal stenosis related to osteophyte formation. Preoperative belirli kriterlere göre osteofitler sınıflandırıldı. Preoperatif ve postoperatif and postoperative visual analouge scale scores for leg pain were bacak visual analog skala değerleri karşılaştırıldı. compared. Bulgular: İstatistiksel analizde cerrahi sonrasında anlamlı iyileşme Results: Statistical analysis revealed significant improvements gözlendi. Ameliyat ettiğimiz hastalarda lomber foramendeki osteofitler after surgical treatment. Osteophytes in the lumbar foramina were belirli kriterlere göre sınıflandırıldı. Sınıflama grade 1’den grade 4’e examined and classified as grades 1 to 4.
[Show full text]
Spondylosis , Facet Joint Arthropathy and Pain
Spondylosis, Facet Joint Arthropathy and Pain Jim Borowczyk Department of Orthopaedics and Musculoskeletal Medicine Christchurch School of Medicine University of Otago Do ‘Age Related’ Changes in the Spinal Column Cause or Contribute to Chronic Pain? And why enquire about this? . Major insurance agencies worldwide covering work and other accident related injury often use the presence of ‘spondylosis’ and ‘facet joint arthropathy’, as seen on imaging, to decline further cover for a particular incident . This often occurs without warning in a setting in which the patient felt an inherent security in the system or process that was expected to provide for his medical rehabilitation, and protection of income while injured . Question Is this a justifiable stance? Yes or No? GPCME South 2010 - Spondylosis and Pain 4 Questions requiring answers . What is the true prevalence of spinal spondylosis and altered zygapophysial (facet joint) morphology? . What is its relation to increasing age? . How much do these changes contribute to spinal pain syndromes? GPCME South 2010 - Spondylosis and Pain 5 Spondylosis - Definitions ‘Spondylosis is a process whereby the morphology of the vertebral bodies change, with the production of marginal osteophytes at the superior and inferior bodies’ ‘One cardinal feature of spondylosis is said to be the development of vertebral body osteophytes’ Bogduk, 1997 (1) GPCME South 2010 - Spondylosis and Pain 6 Spondylosis - Definition ‘Spondylosis is a term referring to degenerative osteoarthritis of the joints between the centra of the spinal vertebrae and or neural foraminae. In this condition the interfacetal joints are not involved’ (Wikipedia – the online encyclopaedia) GPCME South 2010 - Spondylosis and Pain 7 Age Changes in the Spinal Column The ‘Wear and Tear’ of Life Intervertebral Discs 10 The Ageing Disc .
[Show full text]