Anterior Chamber Foldable Phakic Intra Ocular Lens Safety and Efficacy
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Journal of Clinical Research and Ophthalmology eertechz AlAhmady Hamad AlSamman*, Ashraf Research Article Mostafa Moahammed and Usama Ali Mohammed Department of Ophthalmology, Faculty of Medicine, Anterior Chamber Foldable Phakic Sohag University, Egypt Dates: Received: 01 November, 2016; Accepted: Intra Ocular Lens Safety and Efficacy 09 November, 2016; Published: 15 November, 2016 *Corresponding author: Alahmady Hamad Abstract Alsmman, MD, Department of Ophthalmology, Purpose: Correction of myopia by implantation of intra ocular lens is a growing surgery. In this Faculty of Medicine, Sohag University, 82524, study I am trying to assess the visual outcome stability and safety of eyes undergoing Anterior chamber Sohag, Egypt, Tel: 0020-11 11 10 26 98 ; E-mail: foldable phakic lens implantation (Artiflex) (Ophtec BV, Groningen, The Netherlands) or (veriflex) (AMO,Santa Ana,CA) for myopia unsuitable for LASIK and detection of early and late complications www.peertechz.com along three years follow up period. ISSN: 2455-1414 Methods: A retrospective analysis of 25 eyes of 16 patients underwent Anterior chamber foldable phakic IOL (Artiflex) or (Veriflex) implantation for correction of myopia all patients were unsuitable Keywords: Phakic IOL; Myopia; Refractive surgery for LASIK all patients underwent surgery with one surgeon in same circumstances. Uncorrected visual acuity, corrected visual acuity (BCVA), higher-order aberrations, patient satisfaction, central endothelial cell count, and PIOL position centration and incarcerated iris tissue were determined along follow up period. Results: At the end of the 36 months of follow up period 14 of the 25 eyes (56 %) achieved BCVA better than that measured pre-operatively and 10 of the 25 eyes (40%) matched their pre-operative BCVA. One eye (4 %) attained a final BCVA worse than pre-operatively, due to recurrent uveitis. One patient (4%) need another surgery to fixate the lens due to slippage of incarcerated iris tissue with impending displacement. Conclusions: This study suggests that Anterior chamber foldable phakic IOL (iris claw lens insertion) Artiflex or Veriflex is beneficial in myopia, unsuitable for LASIK, matching or exceeding pre- operative BCVA in the overwhelming majority of the cases. With no major complications however long standing follow up is needed to avoid major complications. Abbreviations As many patients with myopia unsuitable for LASIK the Intraocular refractive procedures may be a good alternative: high PIOL: Phakic Intra Ocular Lens; IOL: intraocular Lens; LASIK: degrees of ametropia thin corneas and keratoconus suspect can be Laser Insitu Keratomeleiosis; PRK: Photorefracive Keratectomy; corrected, more stable refraction, better visual quality in day and night BCVA: Best Corrected Visual Acuity; UCVA: Uncorrected Visual Acuity; PMMA: Poly Methel Metha Arylate; ACD: Anterior Chamber and lastly reversibility of our technique all of above make intraocular Depth; ECD: Endothelial Cell Count; SE: Spherical Equivilant refractive surgery is a good alternative in patients refusing glasses and contact lenses [7,8]. Introduction Intraocular refractive surgeries may be classified into: phakic Most of patients are hoping to see well without spectacle or intraocular lens (PIOL) implantation with preservation of crystalline contact lenses. So in last years the refractive surgery increased in lens and clear lens extraction with lens implantation, also called patients dissatisfied with spectacles and contact lenses either due to quality of vision, cosmetic appearance or difficulties in contact refractive lens exchange. Clear lens extraction may increases the risk lenses wearing and its complications. corneal surgeries like corneal for retinal detachment and is generally not preferable in myopic pre- ablation ( photorefractive keratectomy (PRK) and laser-assisted in presbyopic patients who can still accommodate as it deprive them situ keratomileusis LASIK) and different types of phakic intraocular from useful accommodation and always patient suffers from disability lens (PIOL) implantation either in the anterior or posterior chamber of near vision without glasses. Retinal detachment after refractive lens and the anterior chamber either iris claw or angle fixation IOL aim to exchange for high myopia is always present and has been described correct s refractive errors in myopic patients [1,2]. to occur in 2% to 8% of patients which increase if complications Corneal surgeries, such as photorefractive keratectomy (PRK) and occurred during surgery [9,10]. LASIK, have many limitations and contraindications especially for PIOL implantation in suitable patients may be more favorable than the correction of high refractive errors. Postoperative ectasia which other refractive surgery techniques, the PIOL is potentially reversible is a major problem can occur with removing of too much corneal as the PIOL is removable surgically with any major complication. tissue to correct high myopia with the laser. Night bad quality vision Visual recovery is fast, and accommodation is preserved with great and dry eye complaints may be transient or permanent symptoms which may cause dissatisfaction for refractive patients. Due to these benefit in pre presbyopic patients. Implantation of a PIOL utilizes limitations and complications, indications for corneal refractive operative techniques familiar to most anterior segment surgeons surgery have narrowed [3-6]. and does not require expensive or specialised devices, such as an Citation: AlSamman AH, Moahammed AM, Mohammed UA (2016) Anterior Chamber Foldable Phakic Intra Ocular Lens Safety and Efficacy. J Clin Res Ophthalmol 3(1): 034-040. DOI: 10.17352/2455-1414.000033 034 AlSamman, et al. (2016) excimer laser. On the other hand complications relating to PIOLs acuity (BSCVA),) refraction both manifest andand after complete can be more disabling than those from keratorefractive surgery. cycloplegia by cyclopentolate 1% 6 hours before examination and Glaucoma, cataract formation, corneal decompensation, uveitis, and the spherical equivalent (SE) were calculated, meticulus slit-lamp endophthalmitis are potential complications after PIOL insertion examination for the anterior segment , pupil size by manualcard [11]. comparison method was measured, corneal topography endothelial cell density (ECD), applanation tonomety by tonopen and fundus In the 1980s, as an increasing number of reports indicated examination by direct and indirect ophthalmoscopy for detection of complications from use of the angle-supported PIOLs, a new type of peripheral retinal abnormalities . UCVA and BSCVA were measured anterior-chamber PIOL was developed based on the 1977 design of in decimal Snellen and converted to the logarithm of the minimum Jan Worst’s iris-fixated “iris-claw” lens [12-14]. angle of resolution (logMAR). Corneal endothelium count was The name of the PIOL was changed to Artisan (Ophtec BV, evaluated by use of Topcon noncontact specular microscope. Groningen, The Netherlands), and it is available for myopic patients The calculation of the IOL power was done by using van der with powers from −3 to −23.5 D. In 2004, the PIOL gained FDA Heijde formula, which uses the corneal curvature, ACD, and manifest approval under the name Verisyse Phakic IOL (Abbott Medical SE of the refractive error at a vertex distance of 12 mm, the calculation Optics, Inc., Santa Ana, CA), with available powers from −5 to −20 was done in each cases by the manufacturing company. D. A toric Artisan model is also available in Europe with parameters similar to the Artisan, but with cylindrical powers up to -7.5D [15- Surgical technique 17]. Before the surgery by one hour, topical antibiotic Vigamox The Artiflex and Veriflex foldable IOLs are a three-piece lenses (moxifloxacin hydrochloride ophthalmic solution 0.5%) with were developed based on the Artisan design, with a flexible, 6.0-mm pilocarpine 2% (isoptocarpine) was installed in the conjunctival sac convex–concave silicone optic, PMMA haptics, and overall diameter of all eyes every 15 minutes 4 times the miotics installed in order of 8.5 mm. to ease lens fixation in the iris tissue and avoid pupil dilation after anaesthesia and protection of crystalline lens from touch during Myopic IOL is available in powers of −2 to −14.5 D, and it implantation. Surgeries were performed by same surgeon and under utilizes a small (3.2 mm), self-sealing incision, thereby allowing for same circumstances all surgeries were done under general anaesthesia more rapid recovery of visual acuity. The Artiflex has Conformité only 3mm clear corneal incision was performed at 12 o’clock Européene marking in the European Union and is undergoing FDA by keratome ,the anterior chamber reformation by viscoelastic clinical trials as the Veriflex lens (Abbott Medical Optics, Inc.) [18]. material (Healon GV, Abbott Medical Optics, Santa Ana, CA, USA) Aim of the work and two paracentesis were located at 10 o’clock and 2 o’clock. The PIOL was loaded on special spatula (Operaid Artiflex Implantation To assess the visual outcome stability and safety of eyes Spatula, Ophtec, Groningen, and the Netherlands) and introduced undergoing anterior chamber foldable phakic lens implantation into the anterior chamber through keratome opening the lens after (Artiflex and veriflex) for myopia unsuitable for LASIK and detection introduction it will be in vertical position from 12 to 6 o’clock there of early and late complications along three years follow up period. after rotated 90° into a horizontal