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Document De Base D'innate Pharma

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Document De Base D'innate Pharma Société anonyme à directoire et conseil de surveillance au capital social de 857 394 euros réparti en 17 147 880 actions de nominal 0,05 euro Siège social : 121, Ancien Chemin de Cassis 13009 Marseille 424 365 336 RCS Marseille DOCUMENT DE BASE En application de son règlement général et notamment de l’article 212-23, l’Autorité des marchés financiers a enregistré le présent document de base le 19 juin 2006 sous le numéro I.06-102. Il ne peut être utilisé à l’appui d’une opération financière que s’il est complété par une note d’opération visée par l’Autorité des marchés financiers. Ce document de base a été établi par l’émetteur et engage la responsabilité de ses signataires. L’enregistrement, conformément aux dispositions de l’article L. 621-8-1I du Code monétaire et financier, a été effectué après que l’Autorité des marchés financiers a vérifié « si le document est complet et compréhensible et si les informations qu’il contient sont cohérentes ». Il n’implique pas l’authentification des éléments comptables et financiers présentés. Des exemplaires du document de base sont disponibles sans frais auprès de Innate Pharma S.A., 121, Ancien Chemin de Cassis 13009 Marseille ainsi que sur les sites Internet d’Innate Pharma (http://www.innate-pharma.com) et de l’Autorité des marchés financiers (http://www.amf-france.org). NOTE Dans le présent document de base, les expressions « Nous » ou la « Société » désignent la société Innate Pharma S.A. (« Innate Pharma »). Le présent document de base présente notamment les comptes annuels de la Société établis selon les normes comptables applicables en France (les « Comptes Annuels ») pour les exercices clos aux 31 décembre 2003, 2004 et 2005 qui figurent au paragraphe 20.1 du présent document de base. La Société n’ayant pas de filiale, elle n’établit pas de comptes consolidés. La Société a établi pour les exercices clos au 31 décembre 2003, 2004 et 2005, des comptes retraités selon les normes IFRS (les « Comptes selon les Normes IFRS »). Les Comptes selon les Normes IFRS ont été arrêtés par le Directoire le 28 avril 2006. Leur établissement n’étant pas prévu par la loi, ils ne seront pas soumis à l’approbation de l’Assemblée générale de la Société. Ils figurent au paragraphe 20.3 du présent document de base. Le présent document de base contient des déclarations prospectives et des informations sur les objectifs de la Société, notamment au paragraphe 6.2.1 « Notre stratégie » du document de base, qui sont parfois identifiées par l’utilisation du futur, du conditionnel et de termes à caractère prospectif tels que « croire », « estimer », « considérer », « avoir pour objectif », « avoir l’intention de », « envisager de », « anticiper », « s’attendre à », « entendre », « devoir », « souhaiter », « pouvoir » et d’autres termes similaires. Ces informations sont fondées sur des données, hypothèses et estimations considérées comme raisonnables par la Société. Ces déclarations prospectives et ces informations sur les objectifs peuvent être affectées par des risques connus et inconnus, des incertitudes liées notamment à l’environnement réglementaire, économique, financier et concurrentiel, et d’autres facteurs qui pourraient faire en sorte que les résultats futurs, les performances et les réalisations de la Société soient significativement différents des objectifs formulés ou suggérés par ses membres du Directoire, du Conseil de surveillance et ses dirigeants. Ces facteurs peuvent notamment inclure les facteurs exposés au Chapitre 4 — « Facteurs de risques » du présent document de base. La Société, les actionnaires de la Société et les prestataires de services d’investissement ne prennent donc aucun engagement ni ne donnent aucune garantie sur la réalisation de ces données prospectives et de ces objectifs. Les investisseurs sont invités à prendre attentivement en considération les facteurs de risques décrits au Chapitre 4 — « Facteurs de risques » du présent document de base avant de prendre leur décision d’investissement. La réalisation de tout ou partie de ces risques est susceptible d’avoir un effet défavorable significatif sur l’activité, les perspectives, la situation financière, les résultats, le développement de la Société ou ses objectifs. Par ailleurs, d’autres risques, non encore actuellement identifiés ou considérés comme non-significatifs par la Société, pourraient avoir le même effet négatif et les investisseurs pourraient perdre tout ou partie de leur investissement. Le présent document de base contient également des informations relatives aux marchés dans lesquels opère la Société, à leur évolution, à ses concurrents ainsi qu’à son positionnement concurrentiel, notamment aux paragraphes 6.4 et 6.8. Ces informations proviennent notamment d’études réalisées par des sources extérieures et d’estimations de la Société. Concernant, les informations publiquement disponibles, que la Société considère comme fiables, reprises dans le présent document de base ou utilisées par la Société pour effectuer ses propres estimations, elles n’ont pas été vérifiées par un expert indépendant et la Société ne peut pas garantir qu’un tiers utilisant des méthodes différentes pour réunir, analyser ou calculer des données sur les marchés obtiendrait les mêmes résultats. Il est également possible que ces données et estimations soient erronées ou qu’elles ne soient plus à jour, ou encore que les évolutions envisagées n’aient pas lieu, pour les mêmes raisons que celles énoncées ci-dessus. Ceci pourrait avoir un effet défavorable significatif sur l’activité, les perspectives, la situation financière, les résultats, le développement de la Société ou ses objectifs. La Société, ses actionnaires et les prestataires de services d’investissement ne prennent aucun engagement ni ne donnent aucune garantie quant à l’exactitude de ces informations. Un lexique définissant certains termes techniques auxquels il est fait référence ainsi qu’une bibliographie figurent à la fin du présent document de base. INDEX CHAPITRE 1. PERSONNE RESPONSABLE ...................................... 10 1.1 Nom et fonction du responsable du document de base .......................... 10 1.2 Attestation du responsable du document de base .............................. 10 CHAPITRE 2. RESPONSABLES DU CONTROLE DES COMPTES ................... 11 2.1 Commissaires aux comptes titulaires ........................................ 11 2.2 Commissaires aux comptes suppléants ....................................... 11 CHAPITRE 3. INFORMATIONS FINANCIERES ET OPERATIONNELLES SELECTIONNEES ................................................ 12 CHAPITRE 4. FACTEURS DE RISQUES ......................................... 13 4.1 Risques relatifs à notre activité ............................................. 13 4.2 Risques financiers ........................................................ 21 4.3 Risques juridiques ....................................................... 23 4.4 Risques industriels liés à l’environnement .................................... 27 4.5 Assurances et couverture des risques ........................................ 28 4.6 Risques de marché ....................................................... 29 CHAPITRE 5. INFORMATION CONCERNANT LA SOCIETE ...................... 30 5.1 Histoire et évolution de la Société ........................................... 30 5.1.1 Historique de la Société .................................................... 30 5.1.2 Dénomination sociale ...................................................... 31 5.1.3 Registre du commerce et des sociétés ......................................... 31 5.1.4 Date de constitution et durée de la Société ...................................... 31 5.1.5 Siège social, forme juridique et législation applicable ............................. 32 5.1.6 Exercice social ........................................................... 32 5.2 Investissements .......................................................... 32 5.2.1 Investissements historiques ................................................. 32 5.2.2 Investissements en cours ................................................... 32 5.2.3 Investissements futurs ..................................................... 32 CHAPITRE 6. APERCU DES ACTIVITES ........................................ 33 6.1 Introduction ............................................................ 33 6.2 Stratégie et points forts ................................................... 35 6.2.1 Notre stratégie ........................................................... 35 6.2.2 Points forts .............................................................. 35 6.3 Présentation de la Société ................................................. 36 6.3.1 Fondements scientifiques de la Société ........................................ 36 6.3.2 De la découverte d’un candidat-médicament à son enregistrement ................... 39 6.3.3 Organisation et gestion de la recherche et du développement ....................... 41 6.3.4 Expertises et savoir-faire de la Société ......................................... 43 6.3.5 Sous-traitance ............................................................ 44 5 6.4 Contexte industriel et scientifique ........................................... 45 6.4.1 Epidémiologie des cancers .................................................. 45 6.4.2 Données de marché ........................................................ 46 6.5 Approche thérapeutique de la Société ....................................... 48 6.5.1 Immuno-modulation des cellules T gamma delta ou « T γδ » ......................
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