DOCSLIB.ORG

Research Progress of Chitosan-Based Biomimetic Materials

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Research Progress of Chitosan-Based Biomimetic Materials marine drugs Review Research Progress of Chitosan-Based Biomimetic Materials Zhaoyu Zhang, Lingyu Zhang, Chengpeng Li, Xiangyu Xie, Guangfa Li, Zhang Hu * and Sidong Li Faculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhan Jiang 524088, China; [email protected] (Z.Z.); [email protected] (L.Z.); [email protected] (C.L.); [email protected] (X.X.); [email protected] (G.L.); [email protected] (S.L.) * Correspondence: [email protected] Abstract: Chitosan is a linear polysaccharide produced by deacetylation of natural biopolymer chitin. Owing to its good biocompatibility and biodegradability, non-toxicity, and easy processing, it has been widely used in many fields. After billions of years of survival of the fittest, many organisms have already evolved a nearly perfect structure. This paper reviews the research status of biomimetic functional materials that use chitosan as a matrix material to mimic the biological characteristics of bivalves, biological cell matrices, desert beetles, and honeycomb structure of bees. In addition, the application of biomimetic materials in wound healing, hemostasis, drug delivery, and smart materials is briefly overviewed according to their characteristics of adhesion, hemostasis, release, and adsorption. It also discusses prospects for their application and provides a reference for further research and development. Keywords: chitosan; biomimetic materials; mussels; cell matrix 1. Introduction Citation: Zhang, Z.; Zhang, L.; Li, C.; Chitin (CT), the second most abundant natural polysaccharide on earth, after cellulose, Xie, X.; Li, G.; Hu, Z.; Li, S. Research Progress of Chitosan-Based is a major structural component in the exoskeletons of a variety of organisms, including Biomimetic Materials. Mar. Drugs protists, diatoms, sponges, arthropods, molluscs, insects, and arachnids, especially seafood, 2021, 19, 372. https://doi.org/ such as shrimp and crab [1–5]. Traditionally, CT was isolated on a large scale from the 10.3390/md19070372 exoskeletons of fungal organisms and crustaceans. Its extraction includes the chemical method, microbial fermentation, and bioenzymatic hydrolysis [1,6,7]. Chitosan (CS), a Academic Editor: Hitoshi Sashiwa deacetylated derivative of chitin, has net cationicity and a variety of functional groups, which can form electrostatic complexes or multilayer structures with other negatively Received: 30 May 2021 charged substances or natural polymers. In recent years, it has been widely used in many Accepted: 24 June 2021 fields, such as tissue engineering, wound healing, drug transportation, adhesives, and Published: 27 June 2021 adsorption materials, due to its good biocompatibility and biodegradability, safety and non-toxicity, broad-spectrum antibacterial properties, and hemostasis. Additionally, it is Publisher’s Note: MDPI stays neutral easy to process it into gels, membranes, nanofibers, stents, and other forms [8–14]. with regard to jurisdictional claims in Bionics is an emerging discipline that studies the structure, function, and optimization published maps and institutional affil- of biomaterial systems through the intersection of biology, chemistry, and physics. It uses iations. active substances derived from nature to design various structural and functional materials through the principle of bionics. In recent years, it has become a rapidly developing research field [15–17]. In most cases, bionics does not mean directly copying the structure of biological materials; instead, guiding principles are extracted from biological systems Copyright: © 2021 by the authors. for the artificial synthesis of functional materials with relevant characteristics [18–20]. Licensee MDPI, Basel, Switzerland. This review focuses on the imitation of unique structures and functions of some natural This article is an open access article organisms, such as bivalves, biological cell substrates, desert beetles, and honeycomb distributed under the terms and structures of bees, and the preparation of functional materials with related properties conditions of the Creative Commons and their derivatives, using CS as the matrix material (Figure1). The applications of Attribution (CC BY) license (https:// biomimetic materials in wound healing, hemostasis, drug delivery, and smart materials creativecommons.org/licenses/by/ were reviewed according to their unique characteristics of adhesion, hemostasis, release, 4.0/). Mar. Drugs 2021, 19, 372. https://doi.org/10.3390/md19070372 https://www.mdpi.com/journal/marinedrugs Mar. Drugs 2021, 19Mar., 372 Drugs 2021, 19, x FOR PEER REVIEW 2 of 21 2 of 21 and adsorption.adsorption. Meanwhile, Meanwhile, to better to understand better understand the role th ofe CSrole in of biomedicine, CS in biomedicine, tissue tissue engi- engineering, adsorptionneering, adsorption materials, materials, and other and fields, other the fiel preparedds, the prepared CS-based CS-based biomimetic biomimetic mate- materials wererials briefly were summarized briefly summarized according according to theirforms, to their including forms, including scaffold, scaffold, hydrogel, hydrogel, film, film, and compositeand composite material (Tablematerial1). (Table 1). FigureFigure 1. The 1. chitosan-based The chitosan-based biomimetic biomimetic materials material ands theand forms the forms of material of material prepared. prepared. Table 1. ProposedTable applications 1. Proposed of chitosan-basedapplications of materialschitosan-based based materials on forms. based on forms. Forms Composites Applications Ref. Forms Composites Applications Ref. CS, porous poly(ε-caprolactone) (PCL), bioactive glass (BG) polydo- CS, porous poly("-caprolactone) (PCL), bioactive glass (BG) bone tissue engineering [21] pamine (PDA) bone tissue engineering [21] polydopamineCS, (PDA) graphene oxide (GO) bone tissue engineering [22] CS,CS, graphene poly ( L-lactic oxide acid) (GO) aligned microfibrous bundle bone tissue engineeringbioengineering [ 22] [23] Scaffold CS, poly (methyl methacrylate-co-methacrylic acid) (P[MMA-co- Scaffold CS, poly (L-lactic acid) aligned microfibrous bundle bioengineeringbone tissue engineering [23] [24] MAA]), carbodiimide-crosslinker CS, poly (methyl methacrylate-co-methacrylic acid) CS, honeycomb porous carbon (HPC), nano-sized hydroxyapatitebone tissue engineering [24] (P[MMA-co-MAA]), carbodiimide-crosslinker bioengineering [25] (nHA), CS, honeycomb porous carbon (HPC), nano-sized hydroxyapatite CS, catechol bioengineeringbiomedical fields [25 ] [26] (nHA), CS, CS-methacrylate (CS-MA), dopamine (DA), N-methylol acryla- wound healing [27] CS, catecholmide (NMA) biomedical fields [26] CS, CS-methacrylate (CS-MA), dopamineCS, HBC, (DA), DOPA N-methylol wound dressing [28] wound healing [27] acrylamide (NMA)CS, DA chloride wound healing [29] CS, HBC, DOPACS, catechol wound dressingbiomedical fields [28 ] [30] CS, DA chlorideCS, catechol wound healingbiomedical fields [29 ] [31] tetra-succinimidyl carbonate polyethylene glycol (PEG-4S), thiol- CS, catechol biomedical fieldswound healing [ 30] [32] grafted mussel inspired catechol conjugated chitosan (CSDS) Hydrogel Hydrogel CS,CS, catechol methacrylate modified CS, gelatin biomedical fieldswound healing [ 31] [33] tetra-succinimidyl carbonate polyethyleneCS-c, thiolated glycol pluronic (PEG-4S), F-127 tissue engineering [34] wound healing [32] thiol-grafted mussel3, 4-dihydroxyhydrocinnamic inspired catechol conjugated acid glycol chitosan chitosan(g-CS), (CSDS) CS catechol biomedical fields [35] CS, methacrylate modified CS,(CS-c) gelatin wound healing [33] CS, catechol, diatom biomedical fields [36] CS-c, thiolated pluronic F-127 tissue engineering [34] chitosan quaternary ammonium salt (HTCC), oxidized dextran-do- 3, 4-dihydroxyhydrocinnamic acid glycol chitosan(g-CS), CS catechol wound healing [37] pamine (OD-DA) biomedical fields [35] (CS-c) glycol chitosan (GC), ciprofloxacin (Cip), PDA nanoparticles (NPs) wound healing [38] hydroxybutylCS, catechol, chitosan diatom(HBC), L-dopamine (L-DOPA), ε-poly-L-lysine biomedical fields [36] wound healing [39] (EPL) Mar. Drugs 2021, 19, 372 3 of 21 Table 1. Cont. Forms Composites Applications Ref. chitosan quaternary ammonium salt (HTCC), oxidized wound healing [37] dextran-dopamine (OD-DA) glycol chitosan (GC), ciprofloxacin (Cip), PDA nanoparticles (NPs) wound healing [38] hydroxybutyl chitosan (HBC),L-dopamine (L-DOPA), "-poly-L-lysine wound healing [39] (EPL) Hydrogel CS-C, β glycerol phosphate (β-GP), oyster peptides (OP) wound dressing [40] hydrocaffeic acid (HCA)-CS, iron oxide (γ-Fe2O3) MNPs biomedical fields [41] CS, oxidized hyaluronic acid (HAox) catechol terpolymer, Fe wound dressing [42] CS, collagen biomedical fields [43] CS, gelatin, compounded calcium phosphate (CCP) bone tissue engineering [44] combiningcarboxymethyl chitosan (CMCh), amorphous calcium bone tissue engineering [45] phosphate (ACP) CS, layered double hydroxides (LDHs), materials design [46] CS, CaCO3, Al2O3 alumina platelets hybrid materials [47] CS, PDA, silk fibroin nanofibers (SF) biomedical fields [48] CS, delignificated nano-cellulose (DNLC), MoS2 materials [49] CS, HCA, BGNP, catechol biomedical fields [50] CS, alumina sheets bionanocomposite [51] CS, montmorillonite (MTM) bionanocomposite [52] Film O-carboxymethyl CS (CCS), MMT fireproof materials [53] CS, MMT fireproof materials [54] CS, poly (vinyl acetate) (PVAc), tetracycline (TC) biomedical fields [55] CCS, 2-methylacrylloxyethyl phosphorycholine (MPC), PDA, biomedical fields [56] GRGDY peptide CS, MTM, metal ions bionanocomposite
Load more

Recommended publications
  • Biomedical and Clinical Importance of Mussel-Inspired Polymers and Materials
    Mar. Drugs 2015, 13, 6792-6817; doi:10.3390/md13116792 OPEN ACCESS marine drugs ISSN 1660-3397 www.mdpi.com/journal/marinedrugs Review Biomedical and Clinical Importance of Mussel-Inspired Polymers and Materials Nagendra Kumar Kaushik 1,†,*, Neha Kaushik 1,†, Sunil Pardeshi 1, Jai Gopal Sharma 2, Seung Hyun Lee 3 and Eun Ha Choi 1,* 1 Plasma Bioscience Research Center, Kwangwoon University, Seoul 139701, Korea; E-Mails: [email protected] (N.K.); [email protected] (S.P.) 2 Department of Biotechnology, Delhi Technological University, Delhi 110042, India; E-Mail: [email protected] 3 Graduate School of Information Contents, Kwangwoon University, Seoul 139701, Korea; E-Mail: [email protected] † These authors contributed equally in this work. * Authors to whom correspondence should be addressed; E-Mails: [email protected] (N.K.K.); [email protected] (E.H.C.); Tel.: +82-2-940-8618 (N.K.K.); +82-2-940-5661 (E.H.C.); Fax: +82-2-940-5664 (N.K.K.); +82-2-940-5664 (E.H.C.). Academic Editor: Anake Kijjoa Received: 5 October 2015 / Accepted: 3 November 2015 / Published: 11 November 2015 Abstract: The substance secreted by mussels, also known as nature’s glue, is a type of liquid protein that hardens rapidly into a solid water-resistant adhesive material. While in seawater or saline conditions, mussels can adhere to all types of surfaces, sustaining its bonds via mussel adhesive proteins (MAPs), a group of proteins containing 3,4-dihydroxyphenylalanine (DOPA) and catecholic amino acid. Several aspects of this adhesion process have inspired the development of various types of synthetic materials for biomedical applications.
    [Show full text]
  • Engineering of a Biomimetic Interface Between a Native Dental Tissue and Restorative Composite and Its Study Using Synchrotron FTIR Microscopic Mapping
    International Journal of Molecular Sciences Article Engineering of a Biomimetic Interface between a Native Dental Tissue and Restorative Composite and Its Study Using Synchrotron FTIR Microscopic Mapping Pavel Seredin 1,2,* , Dmitry Goloshchapov 1, Yuri Ippolitov 3 and Jitraporn Vongsvivut 4 1 Solid State Physics and Nanostructures Department, Voronezh State University, University sq.1, 394018 Voronezh, Russia; [email protected] 2 Scientific and Educational Center “Nanomaterials and Nanotechnologies”, Ural Federal University named after the first President of Russia B. N. Yeltsin, Mir av., 620002 Yekaterinburg, Russia 3 Department of Pediatric Dentistry with Orthodontia, Voronezh State Medical University, Studentcheskaya st. 11, 394006 Voronezh, Russia; [email protected] 4 ANSTO—Australian Synchrotron, 800 Blackburn Road, Clayton, VIC 3168, Australia; [email protected] * Correspondence: [email protected] Abstract: The aim of this work is to develop a biomimetic interface between the natural tooth tissue and the restorative composite and to study it on the basis of synchrotron micro-FTIR mapping and multidimensional processing of the spectral data array. Using hierarchical cluster analysis of 3D FTIR data revealed marked improvements in the formation of the dentine/adhesive/dental hybrid interface using a biomimetic approach. The use of a biomimetic strategy (application of an amino acid– modified primer, alkaline calcium and a nano-c-HAp–modified adhesive) allowed the formation of a Citation: Seredin, P.; Goloshchapov, matrix that can be structurally integrated with natural dentine and dental composite. The biomimetic D.; Ippolitov, Y.; Vongsvivut, J. hybrid layer was characterised by homogeneous chemical composition and a higher degree of Engineering of a Biomimetic Interface conversion of the adhesive during polymerisation, which should provide optimal integration of the between a Native Dental Tissue and dental composite with the dentine.
    [Show full text]
  • Clinical Perspectives on 3D Bioprinting Paradigms for Regenerative Medicine
    rmf.hapres.com Review Clinical Perspectives on 3D Bioprinting Paradigms for Regenerative Medicine Sadi Loai 1,2,†, Benjamin R. Kingston 1,†, Zongjie Wang 1,3,†, David N. Philpott 3,†, Mingyang Tao 1, Hai-Ling Margaret Cheng 1,2,3,* 1 Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto M5S 3G9, Canada 2 Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, Toronto M5G 1M1, Canada 3 The Edwards S. Rogers Sr. Department of Electrical and Computer Engineering, University of Toronto, Toronto M5S 3G4, Canada † These authors contributed equally to this work. * Correspondence: Hai-Ling Margaret Cheng, Email: [email protected]; Tel.: +1-416-978-4095. ABSTRACT Three-dimensional (3D) bioprinting is an emerging manufacturing technology that layers living cells and biocompatible natural or synthetic materials to build complex, functional living tissue with the requisite 3D geometries. This technology holds tremendous promise across a plethora of applications as diverse as regenerative medicine, pathophysiological studies, and drug testing. Despite some success demonstrated in early attempts to recreate complex tissue structures, however, the field of bioprinting is very much in its infancy. There are a variety of challenges to building viable, functional, and lasting 3D structures, not the least of which is translation from a research to a clinical setting. In this review, the current translational status of 3D bioprinting is assessed for several major tissue types in the body (skin, bone/cartilage, cardiovascular, central/peripheral nervous systems, skeletal muscle, kidney, and liver), recent breakthroughs and current challenges are highlighted, and future prospects for this exciting research field are discussed.
    [Show full text]
  • The Use of Chitosan-Based Scaffolds to Enhance Regeneration in the Nervous System
    AperTO - Archivio Istituzionale Open Access dell'Università di Torino The use of chitosan-based scaffolds to enhance regeneration in the nervous system. This is the author's manuscript Original Citation: Availability: This version is available http://hdl.handle.net/2318/151524 since 2016-06-21T12:34:09Z Publisher: Elsevier Inc. Published version: DOI:10.1016/B978-0-12-420045-6.00001-8 Terms of use: Open Access Anyone can freely access the full text of works made available as "Open Access". Works made available under a Creative Commons license can be used according to the terms and conditions of said license. Use of all other works requires consent of the right holder (author or publisher) if not exempted from copyright protection by the applicable law. (Article begins on next page) 24 September 2021 Thisis an authorversionof the contribution published on: Questa è la versione dell’autore dell’opera: Int Rev Neurobiol. 2013;109:1-62. doi: 10.1016/B978-0-12-420045-6.00001-8. Review. The definitive version is available at: La versione definitiva è disponibile alla URL: http://www.sciencedirect.com/science/article/pii/B9780124200456000018 The Use of Chitosan-Based ScaffoldstoEnhanceRegeneration in the Nervous System Sara Gnavi*, Christina Barwig†, Thomas Freier†, Kirsten Haastert-Talini{, Claudia Grothe{, Stefano Geuna*,1 *Department of Clinical and Biological Sciences, Neuroscience Institute of the Cavalieri Ottolenghi Foundation (NICO), University of Turin, Ospedale San Luigi, Regione Gonzole 10, Orbassano (TO), Italy †Medovent GmbH, Mainz, Germany {Hannover Medical School, Institute of Neuroanatomy & Center for Systems Neuroscience (ZSN), Hannover, Germany 1Corresponding author: e-mail address: [email protected] Abstract Various biomaterials have been proposed to build up scaffolds for promoting neural repair.
    [Show full text]
  • 3D Printing Biomimetic Materials and Structures for Biomedical Applications
    Bio-Design and Manufacturing (2021) 4:405–428 https://doi.org/10.1007/s42242-020-00117-0 REVIEW 3D printing biomimetic materials and structures for biomedical applications Yizhen Zhu1 · Dylan Joralmon1 · Weitong Shan2 · Yiyu Chen3 · Jiahui Rong3 · Hanyu Zhao3 · Siqi Xiao2 · Xiangjia Li1 Received: 26 August 2020 / Accepted: 24 November 2020 / Published online: 3 January 2021 © Zhejiang University Press 2021 Abstract Over millions of years of evolution, nature has created organisms with overwhelming performances due to their unique mate- rials and structures, providing us with valuable inspirations for the development of next-generation biomedical devices. As a promising new technology, 3D printing enables the fabrication of multiscale, multi-material, and multi-functional three- dimensional (3D) biomimetic materials and structures with high precision and great flexibility. The manufacturing challenges of biomedical devices with advanced biomimetic materials and structures for various applications were overcome with the flourishing development of 3D printing technologies. In this paper, the state-of-the-art additive manufacturing of biomimetic materials and structures in the field of biomedical engineering were overviewed. Various kinds of biomedical applications, including implants, lab-on-chip, medicine, microvascular network, and artificial organs and tissues, were respectively dis- cussed. The technical challenges and limitations of biomimetic additive manufacturing in biomedical applications were further investigated, and the potential solutions and intriguing future technological developments of biomimetic 3D printing of biomedical devices were highlighted. Keywords 3D printing · Bioprinting · Biomimetic material · Functional structures · Biomedical applications Introduction tions [1]. A promising rapid prototyping technology, addi- tive manufacturing (AM), also known as three-dimensional Traditional manufacturing methods have been used to fabri- (3D) printing, has emerged to address these shortcomings cate biomedical devices for a long period [1].
    [Show full text]
  • The Effect of Functionalized Self-Assembling Peptide Scaffolds on Human Aortic Endothelial Cell Function
    ARTICLE IN PRESS Biomaterials 26 (2005) 3341–3351 www.elsevier.com/locate/biomaterials The effect of functionalized self-assembling peptide scaffolds on human aortic endothelial cell function Elsa Genove´ a, Colette Shenb, Shuguang Zhanga,c, Carlos E. Seminoa,c,Ã aCenter for Biomedical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA bHarvard University, Cambridge, MA, 02138, USA cBiotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Received 2 February 2004; accepted 10 August 2004 Available online 13 October 2004 Abstract A class of designed self-assembling peptide nanofiber scaffolds with more than 99% water content has been shown to be a good biological material for cell culture. Here, we report the functionalization of one of these peptide scaffolds, RAD16-I (AcN–RADARADARADARADA–CONH2), by direct solid phase synthesis extension at the amino terminal with three short- sequence motifs. These motifs are present in two major protein components of the basement membrane, laminin 1 (YIGSR, RYVVLPR) and collagen IV (TAGSCLRKFSTM). These motifs have been previously shown to promote specific biological activities including endothelial cell adhesion, spreading, and tubular formation. Therefore, the generic functionalized peptide developed was AcN–X–GG-RADARADARADARADA–CONH2 with each motif represented by ‘‘X’’. We show in this work that these tailor-made peptide scaffolds enhance the formation of confluent cell monolayers of human aortic endothelial cells (HAEC) in culture. Moreover, additional assays designed to evaluate endothelial cell function showed that HAEC monolayers obtained on these scaffolds not only maintained LDL uptake activity but also enhanced nitric oxide release and elevated laminin 1 and collagen IV deposition.
    [Show full text]
  • Biomimetic Polymers in Pharmaceutical and Biomedical Sciences
    European Journal of Pharmaceutics and Biopharmaceutics 58 (2004) 385–407 www.elsevier.com/locate/ejpb Review article Biomimetic polymers in pharmaceutical and biomedical sciences S. Drotleffa, U. Lungwitza, M. Breuniga, A. Dennisa,b, T. Blunka, J. Tessmarc,A.Go¨pfericha,* aDepartment of Pharmaceutical Technology, University of Regensburg, Regensburg, Germany bDepartment of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA cDepartment of Bioengineering, Rice University, Houston, TX, USA Received 20 January 2004; accepted in revised form 5 March 2004 Available online 20 May 2004 Abstract This review describes recent developments in the emerging field of biomimetic polymeric biomaterials, which signal to cells via biologically active entities. The described biological effects are, in contrast to many other known interactions, receptor mediated and therefore very specific for certain cell types. As an introduction into this field, first some biological principles are illustrated such as cell attachment, cytokine signaling and endocytosis, which are some of the mechanisms used to control cells with biomimetic polymers. The next topics are then the basic design rules for the creation of biomimetic materials. Here, the major emphasis is on polymers that are assembled in separate building blocks, meaning that the biologically active entity is attached to the polymer in a separate chemical reaction. In that respect, first individual chemical standard reactions that may be used for this step are briefly reviewed. In the following chapter, the emphasis is on polymer types that have been used for the development of several biomimetic materials. There is, thereby, a delineation made between materials that are processed to devices exceeding cellular dimensions and materials predominantly used for the assembly of nanostructures.
    [Show full text]
  • Dorsal Root Injury—A Model for Exploring Pathophysiology and Therapeutic Strategies in Spinal Cord Injury
    cells Review Dorsal Root Injury—A Model for Exploring Pathophysiology and Therapeutic Strategies in Spinal Cord Injury Håkan Aldskogius * and Elena N. Kozlova Laboratory of Regenertive Neurobiology, Biomedical Center, Department of Neuroscience, Uppsala University, 75124 Uppsala, Sweden; [email protected] * Correspondence: [email protected] Abstract: Unraveling the cellular and molecular mechanisms of spinal cord injury is fundamental for our possibility to develop successful therapeutic approaches. These approaches need to address the issues of the emergence of a non-permissive environment for axonal growth in the spinal cord, in combination with a failure of injured neurons to mount an effective regeneration program. Experimental in vivo models are of critical importance for exploring the potential clinical relevance of mechanistic findings and therapeutic innovations. However, the highly complex organization of the spinal cord, comprising multiple types of neurons, which form local neural networks, as well as short and long-ranging ascending or descending pathways, complicates detailed dissection of mechanistic processes, as well as identification/verification of therapeutic targets. Inducing different types of dorsal root injury at specific proximo-distal locations provide opportunities to distinguish key components underlying spinal cord regeneration failure. Crushing or cutting the dorsal root allows detailed analysis of the regeneration program of the sensory neurons, as well as of the glial response at the dorsal root-spinal cord interface without direct trauma to the spinal cord. At the same time, a lesion at this interface creates a localized injury of the spinal cord itself, but with an initial Citation: Aldskogius, H.; Kozlova, neuronal injury affecting only the axons of dorsal root ganglion neurons, and still a glial cell response E.N.
    [Show full text]
  • Biomimetic Materials in Our World: a Review
    IOSR Journal of Applied Chemistry (IOSR-JAC) e-ISSN: 2278-5736. Volume 5, Issue 3 (Sep. – Oct. 2013), PP 22-35 www.iosrjournals.org Biomimetic Materials in Our World: A Review. 1Olugbenga Solomon Bello, 1Kayode Adesina Adegoke, 2Rhoda Oyeladun Oyewole 1Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology P. M. B. 4000, Ogbomoso, Oyo State. 2Department of Chemistry, Federal University of Technology, Akure, Ondo State. Abstract: The study of biomineralization offers valuable and incredible insights into the scope and nature of material chemistry at the inorganic and organic surfaces. Biological systems (architecture) are replete with examples of organic supramolecular assemblies (double and triplet helices, multisubunit proteins, membrane- bound reaction centres, vesicle, tubules e. t. c.), some of which (collagen, cellulose and chitin) extend to microscopic dimensions in the form of hierarchical structure, There are ample opportunities of lessons from the biological (on growth and functional adaptation), and physical (properties and compositions) world. This review explores the field of biomimetic material chemistry as it relates to fibres with respect to their historical perspective, the use of the products of biomimetic material, the progressive efforts and a general overview. Conclusively, biomimetic materials research is indeed a rapidly growing and enormously promising field that needs to be explored. Key words: Biomineralization, helices, material chemistry, nature, supramolecular. I. Introduction The natural world around us provides excellent examples of functional systems built with a handful of materials. Throughout the millennia, nature has evolved to adapt and develop highly sophisticated methods to solve problems [1]. There are numerous examples of functional surfaces, fibrous structures, structural colours, self-healing, thermal insulation, etc., which offer important lessons for the fibre products of the future.
    [Show full text]
  • Monopeptide Versus Monopeptoid: Insights on Structure and Hydration of Aqueous Alanine and Sarcosine Via X-Ray Absorption Spectroscopy
    4702 J. Phys. Chem. B 2010, 114, 4702–4709 Monopeptide versus Monopeptoid: Insights on Structure and Hydration of Aqueous Alanine and Sarcosine via X-ray Absorption Spectroscopy Janel S. Uejio,†,‡ Craig P. Schwartz,†,‡ Andrew M. Duffin,†,‡ Alice England,†,‡ David Prendergast,§ and Richard J. Saykally*,†,‡ Department of Chemistry, UniVersity of California, Berkeley, California 94720-1460 and Chemical Sciences DiVision, Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720 ReceiVed: NoVember 19, 2009; ReVised Manuscript ReceiVed: March 3, 2010 Despite the obvious significance, the aqueous interactions of peptides remain incompletely understood. Their synthetic analogues called peptoids (poly-N-substituted glycines) have recently emerged as a promising biomimetic material, particularly due to their robust secondary structure and resistance to denaturation. We describe comparative near-edge X-ray absorption fine structure spectroscopy studies of aqueous sarcosine, the simplest peptoid, and alanine, its peptide isomer, interpreted by density functional theory calculations. The sarcosine nitrogen K-edge spectrum is blue shifted with respect to that of alanine, in agreement with our calculations; we conclude that this shift results primarily from the methyl group substitution on the nitrogen of sarcosine. Our calculations indicate that the nitrogen K-edge spectrum of alanine differs significantly between dehydrated and hydrated scenarios, while that of the sarcosine zwitterion is less affected by hydration. In contrast, the computed sarcosine spectrum is greatly impacted by conformational variations, while the alanine spectrum is not. This relates to a predicted solvent dependence for alanine, as compared to sarcosine. Additionally, we show the theoretical nitrogen K-edge spectra to be sensitive to the degree of hydration, indicating that experimental X-ray spectroscopy may be able to distinguish between bulk and partial hydration, such as found in confined environments near proteins and in reverse micelles.
    [Show full text]
  • Malini V, Et Al. Self Assembly Peptides- Biomimetic Material. J Dental Sci Copyright© Malini V, Et Al
    Open Access Journal of Dental Sciences ISSN: 2573-8771 Self Assembly Peptides- Biomimetic Material Malini V* Review Article Department of Preventive and Pediatric Dentistry, Kerala University of Health Sciences, Volume 4 Issue 2 India Received Date: April 30, 2019 Published Date: May 14, 2019 *Corresponding author: Malini Venugopal, Consultant Pedodontist, Department of DOI: 10.23880/oajds-16000227 Preventive and Pediatric Dentistry, Kerala University of Health Sciences, Kerala, India, Email: [email protected] Abstract Self-assembling peptides are peptides which undergo spontaneous assembling into ordered nanostructures. As dentistry we are moving towards minimal invasive methods and hence there is a growing interest with regard to this new material. Self assembling peptides can prevent dental caries at an early stage thus preventing surgical process of cavity preparation and restorations. Keywords: Peptides; Biomimetics; Remineralization Introduction minerals, making up most of the enamel structure, is dissolved due to acidic pH and results in pores between Dental Caries is the most common disease worldwide. crystallites. During remineralization, calcium phosphate Inspite of advancement in technologies caries remains the supersaturated saliva redeposit minerals either on single most widespread disease of the childhood. It is now existing crystallites or triggers de novo formation of well known that Dental caries is not a result of a single crystallites. This presents the natural regeneration acid formed attack but it is caused due
    [Show full text]
  • Development of Biomimetic Materials for Enhanced Maturation of Engineered Cardiac Tissue
    DEVELOPMENT OF BIOMIMETIC MATERIALS FOR ENHANCED MATURATION OF ENGINEERED CARDIAC TISSUE by Alexander Jay Hodge A dissertation submitted to the Graduate Faculty of Auburn University in partial fulfillment of the requirements for the Degree of Doctor of Philosophy Auburn, Alabama May 8, 2016 Copyright 2016 by Alexander Jay Hodge Approved by Elizabeth A. Lipke, Chair, Mary and John H. Sanders Endowed Associate Professor of Chemical Engineering Mark E. Byrne, Daniel F. & Josephine Breeden Associate Professor of Chemical Engineering Jin Wang, Walt and Virginia Woltosz Endowed Associate Professor of Chemical Engineering Rajesh Amin, Assistant Professor of Drug Discovery and Development Abstract The creation of cardiac tissue constructs holds potential in the development of clinical and diagnostic platforms, including the creation of novel treatments for patients with heart disease and cost-effective platforms for drug discovery. Many materials and techniques have been investigated for use in creating engineered cardiac tissue; however, formation of engineered myocardium in vitro, particularly when derived from pluripotent cell sources, often results in the creation of cardiac tissue or cardiomyocytes with functional properties that are markedly different from the native adult myocardium. The use of biomimetic materials, those materials that emulate one or more properties of native tissue, may be necessary for obtaining cardiac tissue demonstrating physiologically- relevant electrophysiological properties. In this document, the ability of biomimetic
    [Show full text]