BMC Genomics BioMed Central Research article Open Access Characterization of the genomic region containing the Shadow of Prion Protein (SPRN) gene in sheep Evelyne Lampo1, Mario Van Poucke1, Karine Hugot2, Hélène Hayes3, Alex Van Zeveren1 and Luc J Peelman*1 Address: 1Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, B-9820 Merelbeke, Belgium, 2CRB GADIE, INRA, DGA, Laboratoire de Radiobiologie et d'Etude du Genome, INRA Jouy-en-Josas, F-78352 France ; 1CEA, DSV, DRR, Laboratoire de Radiobiologie et d'Etude du Genome, INRA Jouy-en-Josas, F-78352 France and 3UR 339 Unité de Génétique biochimique et Cytogénétique, INRA Jouy-en-Josas, F-78352 France Email: Evelyne Lampo -
[email protected]; Mario Van Poucke -
[email protected]; Karine Hugot -
[email protected]; Hélène Hayes -
[email protected]; Alex Van Zeveren -
[email protected]; Luc J Peelman* -
[email protected] * Corresponding author Published: 30 May 2007 Received: 29 January 2007 Accepted: 30 May 2007 BMC Genomics 2007, 8:138 doi:10.1186/1471-2164-8-138 This article is available from: http://www.biomedcentral.com/1471-2164/8/138 © 2007 Lampo et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: TSEs are a group of fatal neurodegenerative diseases occurring in man and animals. They are caused by prions, alternatively folded forms of the endogenous prion protein, encoded by PRNP.