RESEARCH ARTICLE Genome-wide analysis of the diversity and ancestry of Korean dogs Bong Hwan Choi1☯, Hasini I. Wijayananda2☯, Soo Hyun Lee2☯, Doo Ho Lee2, Jong Seok Kim3, Seok Il Oh3, Eung Woo Park1, Cheul Koo Lee4, Seung Hwan Lee2* 1 Animal Genome & Bioinformatics, National Institute of Animal Science, RDA, WanJu, Korea, 2 Division of Animal and Dairy Science, Chungnam National University, Daejeon, Korea, 3 Korean Jindo and Domestic Animal Center, Jindo, Korea, 4 Department of Biotechnology, Korea University, Seoul, Korea ☯ These authors contributed equally to this work. *
[email protected] a1111111111 a1111111111 a1111111111 Abstract a1111111111 a1111111111 There are various hypotheses on dog domestication based on archeological and genetic stud- ies. Although many studies have been conducted on the origin of dogs, the existing literature about the ancestry, diversity, and population structure of Korean dogs is sparse. Therefore, this study is focused on the origin, diversity and population structure of Korean dogs. The study OPEN ACCESS sample comprised four major categories, including non-dogs (coyotes and wolves), ancient, Citation: Choi BH, Wijayananda HI, Lee SH, Lee modern and Korean dogs. Selected samples were genotyped using an Illumina CanineHD DH, Kim JS, Oh SI, et al. (2017) Genome-wide array containing 173,662 single nucleotide polymorphisms. The genome-wide data were fil- analysis of the diversity and ancestry of Korean tered using quality control parameters in PLINK 1.9. Only autosomal chromosomes were used dogs. PLoS ONE 12(11): e0188676. https://doi. for further analysis. The negative off-diagonal variance of the genetic relationship matrix analy- org/10.1371/journal.pone.0188676 sis depicted, the variability of samples in each population.