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Hydrocortisone Sodium Phosphate OH the Individual Container May Be Too Small to Bear All the Appro- Priate Labelling Information

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Hydrocortisone Sodium Phosphate OH the Individual Container May Be Too Small to Bear All the Appro- Priate Labelling Information Formocortal/Hydrocortisone 1535 Halcinonide (BAN, USAN, rINN) ⊗ Preparations Hydrocortisone Butyrate (BANM, USAN, rINNM) ⊗ Alcinonide; Halcinonid; Halcinónida; Halcinonidum; Halsinonid; Proprietary Preparations (details are given in Part 3) Butirato de hidrocortisona; Cortisol Butyrate; Hidrokortizon Halsinonidi; SQ-18566. 21-Chloro-9α-fluoro-11β-hydroxy- Austria: Sicorten; Belg.: Sicorten†; Ger.: Sicorten†; Hong Kong: Si- Bütirat; Hydrocortisone, Butyrate d’; Hydrocortisoni Butiras. Hy- corten; Neth.: Sicorten†; Port.: Sicorten†; Spain: Sicorten; Switz.: Si- 16α,17α-isopropylidenedioxypregn-4-ene-3,20-dione. corten; Turk.: Sicorten. drocortisone 17α-butyrate. Гальцинонид Multi-ingredient: Ger.: Sicorten Plus; Hong Kong: Sicorten Plus†; Isra- Гидрокортизона Бутират el: Sicorten Plus†; Port.: Sicorten Plus†; Spain: Sicorten Plus; Switz.: Si- C24H32ClFO5 = 455.0. corten Plus; Venez.: Sicorten Plus†. C25H36O6 = 432.5. CAS — 3093-35-4. CAS — 13609-67-1. ATC — D07AD02. ATC — D07AB02. ATC Vet — QD07AD02. ATC Vet — QD07AB02. Hydrocortisone (BAN, rINN) ⊗ Pharmacopoeias. In Chin., Jpn, and US. Anti-inflammatory Hormone; Compound F; Cortisol; Hidrocor- O CH3 USP 31 (Hydrocortisone Butyrate). A white to practically Cl tisona; Hidrokortizon; Hidrokortizonas; Hydrocortisonum; Hy- white, practically odourless crystalline powder. Practically insol- CH H3C O 3 drokortison; Hydrokortisoni; Hydrokortyzon; 17-Hydroxycorti- uble in water; soluble in alcohol, in acetone, and in methyl alco- HO O costerone; NSC-10483. 11β,17α,21-Trihydroxypregn-4-ene- hol; freely soluble in chloroform; slightly soluble in ether. 3,20-dione. H3CH Гидрокортизон Hydrocortisone Cipionate (BANM, rINNM) ⊗ C H O = 362.5. FH 21 30 5 Cipionato de hidrocortisona; Cortisol Cypionate; Hydrocorti- CAS — 50-23-7. O sone, Cipionate d’; Hydrocortisone Cyclopentylpropionate; Hy- ATC — A01AC03; A07EA02; C05AA01; D07AA02; drocortisone Cypionate; Hydrocortisoni Cipionas. Hydrocorti- H02AB09; S01BA02; S02BA01. sone 21-(3-cyclopentylpropionate). Pharmacopoeias. In Chin. and US. USP 31 (Halcinonide). A white to off-white, odourless, crystal- ATC Vet — QA01AC03; QA07EA02; QC05AA01; Гидрокортизона Ципионат line powder. Insoluble in water and in hexanes; slightly soluble QD07AA02; QD07XA01; QH02AB09; QS01BA02; C H O = 486.6. in alcohol and in ether; soluble in acetone and in chloroform. QS01CB03; QS02BA01. 29 42 6 CAS — 508-99-6. Profile ATC — A01AC03; A07EA02; C05AA01; D07AA02; Halcinonide is a corticosteroid used topically for its glucocorti- O H02AB09; S01BA02; S02BA01. coid activity (p.1490) in the treatment of various skin disorders. OH It is usually used as a 0.1% cream, lotion, or ointment. ATC Vet — QA01AC03; QA07EA02; QC05AA01; H3C OH QD07AA02; QH02AB09; QS01BA02; QS02BA01. When applied topically, particularly to large areas, when the skin HO is broken, or under occlusive dressings, corticosteroids may be H CH absorbed in sufficient amounts to cause systemic effects 3 Hydrocortisone Hydrogen Succinate (p.1490). The effects of topical corticosteroids on the skin are (BANM, rINNM) ⊗ described on p.1492. For recommendations concerning the cor- HH rect use of corticosteroids on the skin, and a rough guide to the Cortisol Hemisuccinate; Hidrogenosuccinato de hidrocortisona; clinical potencies of topical corticosteroids, see p.1497. O Hidrokortizon-hidrogén-szukcinát; Hidrokortizono hemisukcina- tas; Hydrocortisone Hemisuccinate; Hydrocortisone, Hémisuc- Preparations Pharmacopoeias. In Chin., Eur. (see p.vii), Int., Jpn, and US. cinate d’; Hydrocortisone, hydrogénosuccinate d’; Hydrocorti- USP 31: Halcinonide Cream; Halcinonide Ointment; Halcinonide Topical Ph. Eur. 6.2 (Hydrocortisone). A white or almost white, crys- sone Succinate; Hydrocortisoni Hemisuccinas; Hydrocortisoni Solution. talline powder. It shows polymorphism. Practically insoluble in hydrogenosuccinas; Hydrokortison-hydrogen-sukcinát; Hy- Proprietary Preparations (details are given in Part 3) water; sparingly soluble in alcohol and in acetone; slightly solu- drokortisonivetysuksinaatti; Hydrokortisonvätesuccinat. Hydro- Austria: Halog; Braz.: Halog; Canad.: Halog; Cz.: Betacorton; Ger.: Ha- ble in dichloromethane. Protect from light. cortisone 21-(hydrogen succinate). log†; Hong Kong: Halog; India: Cortilate; Indon.: Halog; Ital.: Halciderm; USP 31 (Hydrocortisone). A white to practically white, odour- Mex.: Dermalog; Spain: Halog; Switz.: Betacortone; Turk.: Volog; UK: less, crystalline powder. Very slightly soluble in water and in Гидрокортизона Гемисукцинат Halciderm†; USA: Halog; Venez.: Halog. ether; soluble 1 in 40 of alcohol and 1 in 80 of acetone; slightly C25H34O8 = 462.5. Multi-ingredient: Cz.: Betacorton S; Betacorton U; Ger.: Halog Tri†; soluble in chloroform. Store at a temperature of 25°, excursions CAS — 2203-97-6 (anhydrous hydrocortisone hydrogen India: Cobederm-H; Cortilate-S; Ital.: Anfocort; Halciderm; Halciderm permitted between 15° and 30°. Combi; Mex.: Dermalog-C; Switz.: Betacortone; Betacortone S; Turk.: succinate); 83784-20-7 (hydrocortisone hydrogen succi- Betacorton; Venez.: Halcicomb; Halog. nate monohydrate). Hydrocortisone Acetate (BANM, rINNM) ⊗ ATC — A01AC03; A07EA02; C05AA01; D07AA02; Acetato de hidrocortisona; Cortisol Acetate; Hidrokortizon H02AB09; S01BA02; S02BA01. ATC Vet — QA01AC03; QA07EA02; QC05AA01; Halometasone (rINN) ⊗ Asetat; Hidrokortizon-acetát; Hidrokortizono acetatas; Hydro- cortisone, acétate d’; Hydrocortisoni acetas; Hydrokortisonace- QD07AA02; QH02AB09; QS01BA02; QS02BA01. C-48401-Ba; Halometason; Halometasona; Halométasone; tat; Hydrokortison-acetát; Hydrokortisoniasetaatti; Hydroko- Pharmacopoeias. In Eur. (see p.vii) and Jpn. US allows the Halometasoni; Halometasonum; Halometazon; Halomethasone. rtyzonu octan. Hydrocortisone 21-acetate. anhydrous form or the monohydrate. 2-Chloro-6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpreg- Гидрокортизона Ацетат Ph. Eur. 6.2 (Hydrocortisone Hydrogen Succinate). A white or na-1,4-diene-3,20-dione. almost white, hygroscopic powder. Practically insoluble in wa- C H O = 404.5. Галометазон 23 32 6 ter; freely soluble in dehydrated alcohol and in acetone; dissolves CAS — 50-03-3. C H ClF O = 444.9. in dilute solutions of alkali carbonates and alkali hydroxides. 22 27 2 5 ATC — A01AC03; A07EA02; C05AA01; D07AA02; Store in airtight containers. Protect from light. CAS — 50629-82-8. H02AB09; S01BA02; S02BA01. USP 31 (Hydrocortisone Hemisuccinate). It contains one mole- ATC — D07AC12. ATC Vet — QA01AC03; QA07EA02; QC05AA01; cule of water of hydration or is anhydrous. Store in airtight con- ATC Vet — QD07AC12. QD07AA02; QH02AB09; QS01BA02; QS02BA01. tainers. NOTE. HCOR is a code approved by the BP 2008 for use on single unit doses of eye drops containing hydrocortisone acetate where Hydrocortisone Sodium Phosphate OH the individual container may be too small to bear all the appro- priate labelling information. (BANM, rINNM) ⊗ O Pharmacopoeias. In Chin., Eur. (see p.vii), Int., Jpn, US, and Cortisol Sodium Phosphate; Fosfato sódico de hidrocortisona; H H3C Hydrocortisone, Phosphate Sodique d’; Natrii Hydrocortisoni HO OH Viet. Ph. Eur. 6.2 (Hydrocortisone Acetate). A white or almost Phosphas. Hydrocortisone 21-(disodium orthophosphate). CH 3 white, crystalline powder. Practically insoluble in water; slightly H3C H Натрия Гидрокортизона Фосфат Cl H soluble in dehydrated alcohol and in dichloromethane. Protect from light. C H Na O P = 486.4. F H 21 29 2 8 USP 31 (Hydrocortisone Acetate). A white to practically white, CAS — 6000-74-4. O odourless, crystalline powder. Insoluble in water; soluble 1 in 230 of alcohol and 1 in 200 of chloroform. ATC — A01AC03; A07EA02; C05AA01; D07AA02; HF H02AB09; S01BA02; S02BA01. ATC Vet — QA01AC03; QA07EA02; QC05AA01; Hydrocortisone Buteprate (BANM, rINNM) ⊗ Profile QD07AA02; QH02AB09; QS01BA02; QS02BA01. Halometasone is a corticosteroid used topically for its glucocor- Buteprato de hidrocortisona; Hydrocortisone, Butéprate d’; Hy- Pharmacopoeias. In Br., Jpn, and US. ticoid activity (p.1490) in the treatment of various skin disorders. drocortisone Butyrate Propionate; Hydrocortisone Probutate BP 2008 (Hydrocortisone Sodium Phosphate). A white or al- It is usually used as a cream containing 0.05% of halometasone (USAN); Hydrocortisoni Butepras; TS-408. Hydrocortisone 17- most white, hygroscopic powder. Freely soluble in water; practi- monohydrate. butyrate 21-propionate. cally insoluble in dehydrated alcohol and in chloroform. A 0.5% When applied topically, particularly to large areas, when the skin Гидрокортизона Бутепрат solution in water has a pH of 7.5 to 9.0. Protect from light. is broken, or under occlusive dressings, corticosteroids may be USP 31 (Hydrocortisone Sodium Phosphate). A white to light C H O = 488.6. absorbed in sufficient amounts to cause systemic effects 28 40 7 yellow, odourless or practically odourless, exceedingly hygro- (p.1490). The effects of topical corticosteroids on the skin are CAS — 72590-77-3. scopic, powder. Soluble 1 in 1.5 of water; slightly soluble in al- described on p.1492. For recommendations concerning the cor- ATC — D07AB11. cohol; practically insoluble in chloroform, in dioxan, and in rect use of corticosteroids on the skin, see p.1497. ATC Vet — QD07AB11. ether. Store in airtight containers. The symbol † denotes a preparation no longer actively marketed The symbol ⊗ denotes a substance whose use may be restricted in certain sports (see p.vii) 1536 Corticosteroids Hydrocortisone Sodium Succinate um succinate esters is rapid, while absorption of ly to be less
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