Avoid the Stop and Go of BPH Start and Stay on RAPAFLO® for BPH Symptom Relief

Using RAPAFLO® RAPAFLO® is available only by prescription and is approved to treat male urinary symptoms due to BPH, also called an enlarged prostate. RAPAFLO® should not be used to treat high blood pressure.

Important Safety Information Who should not take RAPAFLO® (silodosin) capsules? Do not take RAPAFLO® if you: • have certain kidney problems. • have certain liver problems.

Please see additional Important Safety Information throughout this brochure and accompanying full Prescribing Information in pocket. Have BPH symptoms? What they may mean

Enlarged prostate— uncomfortable but not uncommon Your doctor has diagnosed you with having BPH, benign prostatic hyperplasia, also known as an enlarged prostate. As men age, having BPH is not unusual. In fact, BPH is the most common prostate problem for men over 50. It affects about 50% of men aged 51-60 and up to 90% of men over 80.

The prostate is about But it can grow to the size of a walnut the size of a baseball. in younger men.

BLADDER The prostate is located below the bladder and surrounds the urethra, the tube that carries urine from the bladder. BPH symptoms occur when the “smooth” muscle of the prostate squeezes the urethra. This, in turn, can affect your bladder URETHRA control. Unfortunately, there is little you can do PROSTATE to avoid BPH.

2 Is BPH linked to prostate cancer? No. While many men share this belief, BPH is not linked to prostate cancer, and men with BPH are not more likely to get prostate cancer. These two very different conditions do share some of the same symptoms, which is why you should always check with your doctor. However, while there is no apparent link between the two, a person who has BPH may also have undiagnosed prostate cancer at the same time or develop it in the future.

TREATING BPH

3 RAPAFLO® helps treat the problem at the source

RAPAFLO® selectively targets the prostate As BPH progresses, the prostate squeezes the urethra and the flow of urine can be affected, which can influence your bladder control. Because RAPAFLO® is highly selective, it is designed to target the areas of the body involved in BPH: the prostate and neck of the bladder, the urethra, and the surrounding tissues. RAPAFLO® is an alpha-blocker, a type of drug that relaxes the “smooth” muscles of the prostate and the bladder base and neck. This effect helps improve the flow of urine to relieve BPH symptoms quickly in a wide range of men, regardless of their age or prostate size.

The selective action of RAPAFLO® helps provide relief of BPH symptoms In clinical studies of RAPAFLO®, many patients reported that RAPAFLO® kept decreasing their BPH symptoms over the entire course of the 12-week studies, beginning in as few as 3 to 4 days.

BLADDER RAPAFLO® is a highly selective alpha-blocker. RAPAFLO® does not shrink the prostate, but targets and relaxes the smooth muscles of the prostate and bladder base and neck to quickly relieve BPH symptoms. URETHRA PROSTATE

Please see additional Important Safety Information throughout this brochure and accompanying 4 full Prescribing Information in pocket. Important Safety Information (cont’d) Who should not take RAPAFLO® (silodosin) capsules? (cont’d) Do not take RAPAFLO® if you: • take certain medications (such as ketoconazole, clarithromycin, itraconazole, ritonavir) that may interact with it. • are allergic to silodosin or any of the ingredients of RAPAFLO®.

What should I tell my doctor before using RAPAFLO®? Before taking RAPAFLO®, tell your doctor if you: • have a history of low blood pressure, especially after taking another medicine. Signs of low blood pressure are fainting, dizziness, and lightheadedness. • have kidney or liver problems. • have a history of prostate cancer.

GET RELIEF WITH RAPAFLO®

For additional product information, please visit www.Rapaflo.com. 5 RAPAFLO®—one treatment for a range of BPH symptoms

BPH symptoms can cause problems for men leading active lives Deciding to talk with your doctor about your symptoms of BPH was the first step to finding relief. Only he or she can recommend what to do next. The good news is that you’re taking steps to not let BPH symptoms control your life. The symptoms of BPH fall into 2 general categories— obstructive and irritative. While you probably don’t have all of the symptoms of BPH, you may be experiencing some of the following:

Obstructive Irritative symptoms symptoms occur drive you to the in the bathroom bathroom These symptoms These are the symptoms are more common that are likely to interfere but generally less with daily activities and bothersome. most often cause men to seek treatment.

Hesitancy and straining Frequency (having to go (finding it difficult to start again less than 2 hours urinating) after finishing)

Weak stream (a trickle Urgency (having to go is all that flows out) “right now”)

Intermittency (stopping Nocturia (getting up at and starting while urinating) night to urinate)

Incomplete emptying (feeling your bladder is not completely empty)

Please see additional Important Safety Information throughout this brochure and accompanying 6 full Prescribing Information in pocket. Fortunately, RAPAFLO® has been shown to improve both obstructive and irritative symptoms of BPH Your doctor has determined that your current symptoms are due to BPH. Still, left untreated, severe BPH symptoms can lead to more serious complications. Some of these problems can include inability to control urination, urinary tract infections, and bladder and kidney damage. That’s why your doctor has started treating your BPH symptoms with RAPAFLO®.

Important Safety Information (cont’d) What should I tell my doctor before using RAPAFLO®? (cont’d) Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

ALWAYS TAKE RAPAFLO® AS YOUR DOCTOR PRESCRIBES

For additional product information, please visit www.Rapaflo.com. 7 How to take RAPAFLO®

Once daily for all-day symptom relief RAPAFLO® is prescribed to be taken as 1 capsule by mouth each day with a meal.

If you have difficulty swallowing capsules, you may carefully open the RAPAFLO® capsule and sprinkle the powder on a tablespoonful of applesauce. The applesauce should be swallowed within 5 minutes—without chewing—and followed with an 8-ounce glass of cool water to ensure the powder is completely swallowed.

Be sure to follow your doctor’s advice on how to take RAPAFLO®.

How to store RAPAFLO® Store RAPAFLO® at room temperature and where it will be protected from light and moisture.

Keep RAPAFLO® capsules out of the reach of children.

Please see additional Important Safety Information throughout this brochure and accompanying 8 full Prescribing Information in pocket. Important Safety Information (cont’d) What should I tell my doctor before using RAPAFLO®? (cont’d) Especially tell your doctor if you take medicines that may interact with RAPAFLO®, such as: • another alpha-blocker medicine. • a medicine to treat high blood pressure like diltiazem or verapamil. • a medicine to treat erectile dysfunction (ED). • antifungal medicines like ketoconazole or itraconazole. • anti-HIV medicines like ritonavir. • immunosuppressive medicines like cyclosporine. If you are planning to have cataract surgery or other eye procedures, tell your eye doctor that you are taking or have taken RAPAFLO®. Know the medicines you take. Keep a list of them and show it to your doctor and pharmacist when you get a new medicine.

HOW CAN YOU SAVE ON RAPAFLO®?

For additional product information, please visit www.Rapaflo.com. 9 Save money with the RAPAFLO® Savings Card

A RAPAFLO® Savings Card means savings with every prescription Help reduce your copay on each prescription of RAPAFLO® when you use the RAPAFLO® Savings Card. If you have commercial prescription drug insurance, you may pay no more than $15 per month for up to 16 months or $40 per 90-day prescription for up to 5 prescription fills*. Activate your card now and start saving while you improve your symptoms of BPH.

Savings start here After activating your card, use it each time you fill a prescription through March 31, 2016.*

This card must be activated before use. RAPAFLO® SAVINGS CARD Visit www.Rapafl oSavings.com or call 1-844-343-7699.

SAVE Most $15 for a 30-capsule prescription ON EACH eligible insured ® patients pay RAPAFLO no more PRESCRIPTION than $40 for a 90-capsule prescription

Bring this card to your pharmacist to enjoy continued savings for up to 16 uses with a 30-capsule prescription fi ll; program expires March 31, 2016. BIN# 004682 PCN# CN GRP# EC44001037 ID# 00000000000

*This offer is valid only for patients with commercial prescription drug insurance and applies to prescriptions for RAPAFLO®. Most eligible insured patients will pay no more than $15 per 30-capsule prescription for each of up to 16 prescription fills OR $40 for a 90-capsule prescription for each of up to 5 prescription fills. Please see full terms and conditions at www.Rapaflo.com. Offer expires 3/31/2016.

Go to www.RapafloSavings.com to get your card

Please see additional Important Safety Information throughout this brochure and accompanying 10 full Prescribing Information in pocket. TAKE THE 90-DAY CHALLENGE

In RAPAFLO® studies, many patients saw their BPH symptoms improve over 90 days of therapy. That means that, from the time they started, their symptoms kept getting better for up to 3 months.

Ask for a 90-day prescription of RAPAFLO® and save even more*

• Greater savings compared to a 30-day prescription • Fewer trips to the pharmacy for RAPAFLO® • No forgetting to refill a 30-day prescription

Important Safety Information (cont’d) What are the possible side effects of RAPAFLO®? RAPAFLO® may cause serious side effects, including: • Decreased blood pressure. RAPAFLO® may cause a sudden drop in your blood pressure upon standing from a sitting or lying position, especially at the start of treatment. Symptoms of low blood pressure may include fainting, dizziness, and feeling light-headed. You should use caution when driving, operating machinery, or performing hazardous tasks when starting therapy. This is especially important if you also take other medicines for high blood pressure.

START AND STAY WITH RAPAFLO®

For additional product information, please visit www.Rapaflo.com. 11 There’s no generic substitute for RAPAFLO®

You should know there is no generic equivalent for RAPAFLO® Your urologist has specifically prescribed RAPAFLO® rather than a generic product. That’s because he or she believes it is the best alpha-blocker to relieve your symptoms of BPH. RAPAFLO® is highly selective in targeting the prostate, bladder base and neck, and urethra. For this reason, it’s important to be sure you insist on the exact medicine your doctor prescribed, not a substitution.

Don’t stop taking RAPAFLO® when your symptoms improve When you start taking RAPAFLO®, you may notice that symptoms begin to improve quickly. That’s a sign it’s working. It is not a sign to stop taking RAPAFLO®. You should continue taking RAPAFLO® exactly as your doctor prescribed. That’s because your symptoms are likely to return if you stop treating them. Adhering to your medication schedule is important for another reason as well. When you take RAPAFLO®, your symptoms continue to improve.

Please see additional Important Safety Information throughout this brochure and accompanying 12 full Prescribing Information in pocket. MAKE SURE THE MEDICINE YOU GET IS RAPAFLO®

Make sure:

• Your name is on the bottle • The dose is correct • It says RAPAFLO® on the bottle • The capsules are the right size, shape, and color

Important Safety Information (cont’d) What are the possible side effects of RAPAFLO®? (cont’d) The most common side effects with RAPAFLO® are: • an orgasm with reduced or no semen. This side effect does not pose a safety concern and will go away when you stop using RAPAFLO®. • dizziness and/or low blood pressure when getting up. • diarrhea. • headache. • stuffy nose or irritated nose and throat.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of RAPAFLO®.

GET ADVICE AND SUPPORT TO HELP YOU BETTER MANAGE YOUR BPH

For additional product information, please visit www.Rapaflo.com. 13 Maintaining a healthy prostate

Small changes can make a big difference in prostate health A healthy prostate and a healthy lifestyle may go hand-in-hand. Of course, there is no way to guarantee prostate health. But, there are some things you can do to reduce the risk of problems. Simple lifestyle changes you can make include:

Urinate when you first get the urge. If you know you won’t be near a bathroom, urinate beforehand, even if you don’t feel the need to go.

Avoid alcohol and caffeine, especially after dinner.

Know about your other medications. Some over-the-counter cold and sinus medicines may increase your symptoms.

Keep warm and exercise regularly.

Reduce stress as much as possible.

Please see Important Safety Information throughout this brochure and accompanying 14 full Prescribing Information in pocket. Visit or call these helpful organizations to learn more about maintaining prostate health

Urology Care Foundation 1-800-828-7866 www.urologyhealth.org National Association for Continence 1-800-252-3337 (1-800-BLADDER) www.nafc.org Prostate Health Education Network 1-617-481-4020 www.prostatehealthed.org Well Spouse Association 1-800-838-0879 www.wellspouse.org

VISIT WWW.RAPAFLO.COM FOR INFORMATION, VIDEOS, AND TOOLS

For additional product information, please visit www.Rapaflo.com. 15 Relief Starts With RAPAFLO®

RAPAFLO® helps provide relief of both irritative and obstructive BPH symptoms. Patients experience ongoing symptom improvement over 90 days of therapy.

SAVE WITH THE RAPAFLO® SAVINGS CARD Ask for a 90-day prescription and get greater savings compared to a 30-day prescription.* *$15 for a 30-capsule supply; $40 for a 90-capsule supply. Offer expires 3/31/2016. Please see full terms and conditions at www.Rapaflo.com.

Using RAPAFLO® RAPAFLO® (silodosin) is available only by prescription and is approved to treat male urinary symptoms due to BPH, also called an enlarged prostate. RAPAFLO® should not be used to treat high blood pressure. Please see Important Safety Information throughout this brochure and accompanying full Prescribing Information in pocket.

Models are for illustrative purposes only. Actavis® and its design and RAPAFLO® and its design are trademarks and registered trademarks of Actavis, Inc. or its affiliates. © Actavis 2015. All rights reserved. APC13YN15 07/15