Schedule of Investments Health Care Fund
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Objectives & Accreditation
Objectives & Accreditation ACTIVITY FORMAT Live TARGET AUDIENCE This activity is designed to meet the needs of physicians, physician assistants, pharmacists, registered nurses, nurse practitioners, advance practice registered nurses, and registered dietitians with an interest in lipid management. TYPE OF ACTIVITY Live Activity; Application/ Knowledge EDUCATIONAL OBJECTIVES At the conclusion of this activity, Registered Nurses and Nurse Practitioners should be able to provide appropriate care and counsel for patients and their families. At the conclusion of this activity, all participants should be able to: Session I: The Impact of Genetics in Lipidology? Apply insight from human population genetics studies to identify novel therapeutic targets for a better understanding for atherosclerotic cardiovascular disease. Describe the current and future technologies available for genetic screen includinghow to apply them in clinical practice both for diagnosis and risk assessment Discuss experimental techniques in development for genetic manipulation to target inherited lipid disorders Keynote I Discuss ApoC3 as both a risk factor for ASCVD and as potential for therapeutic manipulation Session II- Focus on Lipoprotein (a) Discuss the epidemiology of Lipoprotein(a) (LP(a)) for both thrombosis and ASCVD Discuss the pathophysiology of LP(a) and how this impacts increased risk of ASCVD and thrombosis Discuss the status of current and emerging treatment options targeting LP(a) Clinical Lipidology Track- Critically appraise emerging research -
Pioneering New Markets Changing the Standard of Care
ANNUAL 2020 REPORT Pioneering New Markets Changing the Standard of Care UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 □ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 000-19125 Ionis Pharmaceuticals, Inc. (Exact name of Registrant as specified in its charter) Delaware 33-0336973 (State or other jurisdiction of (IRS Employer incorporation or organization) Identification No.) 2855 Gazelle Court, Carlsbad, CA 92010 (Address of Principal Executive Offices) (Zip Code) 760-931-9200 (Registrant’s telephone number, including area code) Securities registered pursuant to Section 12(b) of the Act: Title of each class Trading symbol Name of each exchange on which registered Common Stock, $.001 Par Value ‘‘IONS’’ The Nasdaq Stock Market LLC Securities registered pursuant to Section 12(g) of the Act: None Indicate by check mark if the Registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ☒ No □ Indicate by check if the Registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. Yes □ No ☒ Indicate by check mark whether the Registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. -
Polen Capital and the Focus Growth Some of Our Faster-Growing Technology Strategy
Polen Focus Growth Portfolio Manager Commentary – September 2020 Summary • During the third quarter of 2020, the Polen Focus • Gambling-like behavior in the market should give Growth Composite Portfolio (the “Portfolio”) anyone pause in our view, and we are remaining returned 10.15% gross of fees versus 13.22% for the conservative in our estimates of future earnings Russell 1000 Growth Index (the Index”) and 8.93% for growth and the prices we are willing to pay. the S&P 500. Year to date, the Portfolio has returned 22.25% gross of fees versus 24.33% for the Russell • In the third quarter, we initiated new positions in 1000 Growth and 5.57% for the S&P 500. UnitedHealth Group and Intuitive Surgical and eliminated our position in ADP. We also trimmed our • The U.S. election is just around the corner, and while positions in MSCI, ServiceNow, PayPal, Align the outcome is uncertain, we believe the operating Technology, and Microsoft. environment for our businesses over the long run is unlikely to change materially. • Valuations in the U.S. equity market continued to climb in the third quarter. While we feel comfortable with the businesses we own and their valuations, we have seen some ebullient behavior in certain companies that gives us pause. Seeks Growth & Capital Preservation (Performance (%) as of 9-30-2020) 1 Yr 3 Yr 5 Yr Inception 40 30 20 10 0 Qtr YTD 1 Yr 3 Yr 5 Yr Inception Polen Focus Growth (Gross) 10.15 22.25 35.17 24.83 21.04 15.42 Polen Focus Growth (Net) 10.01 21.81 34.53 24.24 20.46 14.43 Russell 1000 Growth TR 13.22 24.33 37.54 21.68 20.11 11.24 S&P 500 TR 8.93 5.57 15.15 12.28 14.15 10.53 The performance data quoted represents past performance and does not guarantee future results. -
Q1 Pharma Sector Snapshot
SPECIALTY & GENERIC PHARMA Q1 2021 Report Market Commentary – Debt Capital Markets Debt Markets ▪ 2020 saw increased amounts of debt used in buyouts across the board, resulting in the highest debt / EBITDA Median US Buyout Multiples levels since 2014 − The increased use of debt was driven by 2H20 back- end loaded lending activity (primarily 4Q20) as 16.0x 12.7x 14.1x 12.2x 12.0x 11.6x 11.5x certainty around the U.S. election and vaccination 11.1x 10.0x 9.8x 12.0x 9.7x expectations increased 9.4x 8.6x 8.3x 8.2x 7.5x 7.8x 5.2x 6.7x 5.7x 5.6x ▪ 8.0x 5.9x As the effects of COVID now begin to diminish, debt 5.4x 4.4x 4.1x 3.7x 4.6x 4.3x 3.8x markets have seemingly recovered, signaling that 3.6x lenders have become increasingly comfortable with 4.0x 4.3x 6.9x 6.5x 6.3x 6.0x 5.9x 5.7x 5.7x 5.7x 5.7x 5.6x 5.3x 4.5x 4.4x macroeconomic and company-specific fundamentals 4.3x 0.0x 3.2x − With increased confidence, lenders are currently looking to provide strong leverage for high-quality assets, particularly ones that have proven their Debt/EBITDA Equity/EBITDA EV/EBITDA stability through the recent market downturn Source: PitchBook ▪ The spread on U.S. high-yield debt has returned to pre- Historical US High Yield Debt Effective Yield COVID levels − 4.22% current effective yield compared with a 12.0% 11.4% 11.38% effective yield on March 23, 2020 (peak of the pandemic) 9.0% ▪ We expect increased activity by lenders in 2021 due to: 6.0% 4.2% − Pent-up demand in M&A activity driven by the impact of COVID 3.0% − Limited Partner agreements and investor -
SUNAMERICA SERIES TRUST Form NPORT-P Filed 2019-12-27
SECURITIES AND EXCHANGE COMMISSION FORM NPORT-P Filing Date: 2019-12-27 | Period of Report: 2019-10-31 SEC Accession No. 0001752724-19-204507 (HTML Version on secdatabase.com) FILER SUNAMERICA SERIES TRUST Mailing Address Business Address HARBORSIDE 5 21650 OXNARD STREET, CIK:892538| IRS No.: 137002445 | State of Incorp.:MA | Fiscal Year End: 0131 185 HUDSON STREET, 10TH FLOOR Type: NPORT-P | Act: 40 | File No.: 811-07238 | Film No.: 191313138 SUITE 3300 WOODLAND HILLS CA 91367 JERSEY CITY NJ 07311 201-324-6378 Copyright © 2019 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document SunAmerica Series Trust SA AB Growth Portfolio PORTFOLIO OF INVESTMENTS October 31, 2019 (unaudited) Value Security Description Shares (Note 1) COMMON STOCKS 91.6% Applications Software 6.8% Microsoft Corp. 758,520 $108,749,012 Athletic Footwear 2.6% NIKE, Inc., Class B 461,910 41,364,041 Beverages-Non-alcoholic 3.4% Monster Beverage Corp. 981,694 55,102,484 Beverages-Wine/Spirits 0.5% Constellation Brands, Inc., Class A 44,620 8,492,525 Coatings/Paint 2.2% Sherwin-Williams Co. 60,890 34,848,565 Commercial Services-Finance 3.1% Euronet Worldwide, Inc. 2,997 419,790 PayPal Holdings, Inc. 400,430 41,684,763 S&P Global, Inc. 30,810 7,948,672 50,053,225 Computer Aided Design 0.1% ANSYS, Inc. 4,069 895,790 Computers 0.9% Apple, Inc. 60,940 15,159,434 Dental Supplies & Equipment 0.8% Align Technology, Inc. 49,480 12,483,309 Distribution/Wholesale 1.3% Copart, Inc. -
ARK GENOMIC REVOLUTION MULTI SECTOR ETF (ARKG) HOLDINGS As of 09/27/2021
ARK GENOMIC REVOLUTION MULTI SECTOR ETF (ARKG) HOLDINGS As of 09/27/2021 Company Ticker CUSIP Shares Market Value($) Weight(%) 1 TELADOC HEALTH INC TDOC 87918A105 3,937,797 531,208,815.30 6.99 2 EXACT SCIENCES CORP EXAS 30063P105 3,971,013 381,296,668.26 5.01 3 PACIFIC BIOSCIENCES OF CALIF PACB 69404D108 13,696,148 350,347,465.84 4.61 4 VERTEX PHARMACEUTICALS INC VRTX 92532F100 1,722,281 316,228,014.41 4.16 5 FATE THERAPEUTICS INC FATE 31189P102 4,825,395 312,926,865.75 4.12 6 IONIS PHARMACEUTICALS INC IONS 462222100 8,572,965 310,341,333.00 4.08 7 REGENERON PHARMACEUTICALS REGN 75886F107 430,742 275,201,063.80 3.62 8 TWIST BIOSCIENCE CORP TWST 90184D100 2,237,350 250,829,308.50 3.30 9 TAKEDA PHARMACEUTIC-SP ADR TAK UN 874060205 13,592,076 229,570,163.64 3.02 10 ACCOLADE INC ACCD 00437E102 5,268,242 226,850,500.52 2.98 11 INTELLIA THERAPEUTICS INC NTLA 45826J105 1,508,421 224,965,907.94 2.96 12 VEEVA SYSTEMS INC-CLASS A VEEV 922475108 741,198 222,307,516.14 2.92 13 CAREDX INC CDNA 14167L103 3,433,475 220,978,451.00 2.91 14 CRISPR THERAPEUTICS AG CRSP H17182108 1,804,041 210,044,493.63 2.76 15 INCYTE CORP INCY 45337C102 2,893,385 199,643,565.00 2.63 16 INVITAE CORP NVTA 46185L103 6,059,066 182,135,523.96 2.40 17 ADAPTIVE BIOTECHNOLOGIES ADPT 00650F109 4,888,391 178,377,387.59 2.35 18 BEAM THERAPEUTICS INC BEAM 07373V105 1,849,698 175,110,909.66 2.30 19 SIGNIFY HEALTH INC -CLASS A SGFY 82671G100 8,107,683 160,937,507.55 2.12 20 UIPATH INC - CLASS A PATH 90364P105 2,955,628 155,761,595.60 2.05 21 CASTLE BIOSCIENCES INC CSTL 14843C105 2,130,211 -
COVID-19 Treatment and Vaccine Tracker This Document Contains an Aggregation of Publicly Available Information from Validated Sources
COVID-19 Treatment and Vaccine Tracker This document contains an aggregation of publicly available information from validated sources. It is not an endorsement of one approach or treatment over another but simply a list of all treatments and vaccines currently in development. TREATMENTS Current Type of FDA-Approved Clinical Trials for Funding Clinical Trials for Anticipated Next Number Developer/Researcher Stage of Published Results Sources Product - Treatment Indications Other Diseases Sources COVID-19 Steps Timing Development ANTIBODIES PhRMA Begin Phase 1 trials in late Polyclonal hyperimmune Alliance among Takeda, CSL Behring, Wall Street Journal spring. To patients between 1 globulin (H-IG), formerly N/A Biotest AG, Bio Products Laboratory, Pre-clinical Pink Sheet December 2020 and December known at TAK-888 LFB, and Octapharma Press release from the 2021 alliance Biomedical Stat News Advanced MarketWatch Antibodies from mice, Research and Reuters 2 REGN3048-3051, against the N/A Regeneron Pre-clinical Start Phase 1 June 2020 Development Bloomberg News spike protein Authority FierceBiotech (BARDA) FiercePharma Korea Herald Antibodies from recovered 3 N/A Celltrion Pre-clinical Start Phase 1 in July 2020 UPI COVID-19 patients Celltrion press release Super-antibody or antibody 4 cocktail to target potential N/A Celltrion Pre-clinical Celltrion press release mutations of SARS-CoV-2 Antibodies from recovered BioSpace 5 N/A Kamada Pre-clinical COVID-19 patients AbbVie Stat News Antibodies from recovered 6 N/A Vir Biotech/WuXi Biologics/Biogen Pre-clinical Start Phase 1 ~ July 2020 Vir Biotech COVID-19 patients Vir Biotech * Indicates updated or new field This document contains an aggregation of publicly available information from validated sources. -
Amgen 2008 Annual Report and Financial Summary Pioneering Science Delivers Vital Medicines
Amgen 2008 Annual Report and Financial Summary Pioneering science delivers vital medicines About Amgen Products Amgen discovers, develops, manufactures Aranesp® (darbepoetin alfa) and delivers innovative human therapeutics. ® A biotechnology pioneer since 1980, Amgen Enbrel (etanercept) was one of the fi rst companies to realize ® the new science’s promise by bringing EPOGEN (Epoetin alfa) safe and effective medicines from the lab Neulasta® (pegfi lgrastim) to the manufacturing plant to patients. NEUPOGEN® (Filgrastim) Amgen therapeutics have changed the practice of medicine, helping millions of Nplate® (romiplostim) people around the world in the fi ght against ® cancer, kidney disease, rheumatoid Sensipar (cinacalcet) arthritis and other serious illnesses, and so Vectibix® (panitumumab) far, more than 15 million patients worldwide have been treated with Amgen products. With a broad and deep pipeline of potential new medicines, Amgen remains committed to advancing science to dramatically improve people’s lives. 0405 06 07 08 0405 06 07 08 0405 06 07 08 0405 06 07 08 Total revenues “Adjusted” earnings Cash fl ow from “Adjusted” research and ($ in millions) per share (EPS)* operations development (R&D) expenses* (Diluted) ($ in millions) ($ in millions) 2008 $15,003 2008 $4.55 2008 $5,988 2008 $2,910 2007 14,771 2007 4.29 2007 5,401 2007 3,064 2006 14,268 2006 3.90 2006 5,389 2006 3,191 2005 12,430 2005 3.20 2005 4,911 2005 2,302 2004 10,550 2004 2.40 2004 3,697 2004 1,996 * “ Adjusted” EPS and “adjusted” R&D expenses are non-GAAP fi nancial measures. See page 8 for reconciliations of these non-GAAP fi nancial measures to U.S. -
Large Cap Value Fund Q3 Portfolio Holdings
Putnam Equity Income Fund The fund's portfolio 8/31/20 (Unaudited) COMMON STOCKS (95.5%)(a) Shares Value Aerospace and defense (3.0%) Northrop Grumman Corp. 763,179 $261,472,757 Raytheon Technologies Corp. 1,931,815 117,840,715 379,313,472 Airlines (1.0%) Southwest Airlines Co. 3,596,011 135,138,093 135,138,093 Auto components (0.8%) Delphi Automotive PLC 1,165,950 100,411,614 100,411,614 Automobiles (0.7%) General Motors Co. 2,932,830 86,899,753 86,899,753 Banks (9.9%) Bank of America Corp. 13,888,550 357,491,277 Citigroup, Inc. 6,615,251 338,171,631 JPMorgan Chase & Co. 3,413,635 342,012,091 KeyCorp 3,945,705 48,611,086 PNC Financial Services Group, Inc. (The) 1,279,414 142,270,837 1,228,556,922 Beverages (2.5%) Keurig Dr Pepper, Inc.(S) 3,097,349 92,393,921 Molson Coors Beverage Co. Class B(S) 1,663,844 62,627,088 PepsiCo, Inc. 1,123,779 157,396,487 312,417,496 Biotechnology (4.5%) AbbVie, Inc. 2,005,931 192,108,012 Amgen, Inc. 804,202 203,720,451 Regeneron Pharmaceuticals, Inc.(NON) 262,080 162,471,254 558,299,717 Building products (2.3%) Fortune Brands Home & Security, Inc. 1,681,051 141,342,768 Johnson Controls International PLC 3,432,811 139,818,392 281,161,160 Capital markets (3.5%) Apollo Global Management, Inc. 2,289,153 107,292,601 Charles Schwab Corp. (The) 2,516,793 89,421,655 Goldman Sachs Group, Inc. -
Sigma Spectrum Operator's Manual
spectrum Operator’s Manual 35700BAX & 35700ABB Generation 2 Operating System Pump Operating Software v6.05 For Use with MDL Editor v6.2.4 SIGMA, LLC 711 Park Avenue Medina, New York 14103 v 800 356 3454 f 585 798 3909 www.sigmapumps.com Manual 41018- 6.05/6.2.4 Revision D II Pump Operating Software v6.05 For Use With MDL Editor v6.2.4 ©2011 Copyright SIGMA, LLC 711 Park Avenue Medina, New York 14103 v 800 356 3454 f 585 798 3909 www.sigmapumps.com III Manual 41018- 6.05/6.2.4 Revision D IV Pump Operating Software v6.05 For Use With MDL Editor v6.2.4 TABLE OF CONTENTS Introduction and Safety . 1 Intended Device Use . 1 Related Documents . 1 Regulatory Information . 1 Contacting SIGMA Technical Support . 1 Conventions . 2 Summary of Warnings and Cautions . 2 System Components . 11 Spectrum Pump Illustrations . 12 Hardware Labeling . 13 Battery Compatibility . 14 Setting Up the Pump . 15 Unpack the Pump . 15 AC Power Adaptor . 16 Cleaning the Power Adaptor . 16 Connecting the Power Adaptor . 16 Removing the Power Adaptor . 17 Charging the Battery . 17 Configuring User Options . 18 User Options . 18 Operational Overview . 21 Starting a New Infusion Using the Dose Error Reduction System (DERS) . 24 Starting a New Infusion using the BASIC Mode . 25 Secondary Infusions . 26 Preparing the Pump and IV Sets . 27 Loading an IV Set . 28 Unloading an IV Set . 30 Preparing the Pump for a Secondary Infusion . 30 Programming the Pump . 31 Infusion Programming Modes: . 32 Keys Used to Program and Operate the Pump . -
Companies in Attendance
COMPANIES IN ATTENDANCE Abbott Diabetes Care Archbow Consulting LLC Business One Technologies Abbott Laboratories ARKRAY USA BusinessOneTech AbbVie Armory Hill Advocates, LLC CastiaRX ACADIA Artia Solutions Catalyst Acaria Health Asembia Celgene Accredo Assertio Therapeutics Celltrion Acer Therapeutics AssistRx Center for Creative Leadership Acorda Therapeutics Astellas Pharma US Inc. Cigna Actelion AstraZeneca Cigna Specialty Pharmacy AdhereTech Athenex Oncology Circassia Advantage Point Solutions Avanir Coeus Consulting Group Aerie Pharmaceuticals Avella Coherus Biosciences AGIOS AveXis Collaborative Associates LLC Aimmune Theraputics Bank of America Collegium Akcea Therapeutics Bausch Health Corsica Life Sciences Akebia Therapeutics Bayer U.S. CoverMyMeds Alder BioPharmaceuticals Becton Dickinson Creehan & Company, Inc., an Inovalon Company Alexion Biofrontera CSL Behring Alkermes Biogen Curant Health Allergan Biohaven CVS Health Almirall BioMarin D2 Consulting Alnylam BioMatrix Specialty Pharmacy Daiichi Sankyo Amarin BioPlus Specialty Pharmacy DBV Technologies Amber Pharmacy Bioventus Deloitte Consulting LLP AmerisourceBergen Blue Cross Blue Shield Association Dendreon Amgen Blue Fin Group Dermira Amicus Therapeutics bluebird bio Dexcom Amneal Boehringer Ingelheim Diplomat Pharmacy Anthem Boston Biomedical Dova Applied Policy Bowler and Company Decision Resources Group Aquestive Therapeutics Braeburn Eisai Arbor Pharmaceuticals Bristol-Myers Squibb 1 electroCore Indivior Merz Pharmaceuticals EMD Serono Inside Rx Milliman Encore Dermatology, -
Valeant Pharmaceuticals International, Inc. 2012 Annual Report Valeant Inc
Valeant Pharmaceuticals International, Inc. 2012 Annual Report Valeant Pharmaceuticals International, Inc. 2012 Annual Report Valeant Gathering Momentum Company Overview Valeant Pharmaceuticals International, Inc. (NYSE/TSX:VRX) is a multinational specialty pharmaceutical company that develops and markets prescription and non-prescription pharmaceutical products that make a meaningful difference in patients’ lives. Valeant’s primary focus is principally in the areas of dermatology and neurology. The Company’s growth strategy is to acquire, develop and commercialize new products through strategic partnerships, and build on the company’s strength in dermatology and neurology. Valeant plans to strategically expand its pipeline by adding new compounds or products through product or company acquisitions and will maximize its pipeline through strategic partnering to optimize its research and development assets and strengthen ongoing internal development capabilities. Valeant’s strategic markets are primarily in the United States, Canada, Central and Eastern Europe, Latin America, Australia and South East Asia. Headquartered in Montreal, Quebec, Valeant has approximately 7,000 employees worldwide. FORWARD-LOOKING Statements In addition to current and historical information, this Annual Report contains forward-looking statements, including, without limitation, statements regarding our strategy, expected future revenue, the prospects for approval of product candidates and the timing of regulatory approvals, and the growth and future development of the company, its business units and its products. Words such as “expects,” “anticipates,” “intends,” “plans,” “should,” “could,” “would,” “may,” “will,” “believes,” “estimates,” “potential,” or “continue” or similar language identify forward-looking statements. Forward-looking statements involve known and unknown risks and uncertainties. Our actual results may differ materially from those contemplated by the forward-looking statements.