Author Manuscript Published OnlineFirst on July 29, 2019; DOI: 10.1158/0008-5472.CAN-19-0086 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Inactivation of proprotein convertases in T cells inhibits PD-1 expression and creates a favorable immune microenvironment in colorectal cancer Mercedes Tomé,1,2 Angela Pappalardo,3 Fabienne Soulet,1,2 José Javier López,4 Jone Olaizola,1,2 Yannick Leger,1,2 Marielle Dubreuil,1,2 Amandine Mouchard,1,5 Delphine Fessart, 5,6 Frédéric Delom, 5,6 Vincent Pitard,3 Dominique Bechade,5 Mariane Fonck,5 Juan Antonio Rosado,4 François Ghiringhelli,7 Julie Déchanet-Merville,3 Isabelle Soubeyran,5 Geraldine Siegfried,1,2 Serge Evrard,1,2,5,* Abdel-Majid Khatib,1,2,* *: Equal Contributions 1 Université Bordeaux, 33000, Bordeaux, France 2 INSERM UMR1029, 33400, Pessac, France 3 ImmunoConcept, CNRS UMR 5164, University of Bordeaux, F-33000 Bordeaux, France 4 Department of Physiology, Veterinary Faculty, University of Extremadura, 10003 Caceres, Spain. 5 Institut Bergonié, Bordeaux, France 6 INSERM U1218, ACTION, Bordeaux, France. 7 INSERM UMR1231, Dijon, France. Corresponding authors:
[email protected]; Phone: 33-540002953 and
[email protected]; Phone: 33-540008705 INSERM U1029, Bordeaux University, Bat. B2 Ouest Allée Geoffroy St Hilaire CS50023, 33615 PESSAC CEDEX Running Title: Proprotein Convertases and PD-1 expression Keywords: Proprotein convertases, furin, PD-1, cancer immunoresponse, T-cells, cytotoxicity 1 Downloaded from cancerres.aacrjournals.org on September 27, 2021. © 2019 American Association for Cancer Research. Author Manuscript Published OnlineFirst on July 29, 2019; DOI: 10.1158/0008-5472.CAN-19-0086 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited.