antibiotics Article Antimicrobial Effect of Natural Berry Juices on Common Oral Pathogenic Bacteria Stefan Kranz 1,*, André Guellmar 1, Philipp Olschowsky 1, Silke Tonndorf-Martini 1, Markus Heyder 1, Wolfgang Pfister 2, Markus Reise 1 and Bernd Sigusch 1 1 Department of Conservative Dentistry and Periodontology, Jena University Hospital, Friedrich-Schiller-University, An der Alten Post 4, 07743 Jena, Germany;
[email protected] (A.G.);
[email protected] (P.O.);
[email protected] (S.T.-M.);
[email protected] (M.H.);
[email protected] (M.R.);
[email protected] (B.S.) 2 Institute for Medical Microbiology, University Hospital Jena, Erlanger Allee 101, 07747 Jena, Germany; Wolfgang.Pfi
[email protected] * Correspondence:
[email protected] Received: 31 July 2020; Accepted: 20 August 2020; Published: 24 August 2020 Abstract: (1) Background: Antimicrobial agents such as chlorhexidine (CHX) are commonly used in oral plaque control. However, sometimes those agents lack antimicrobial efficiency or cause undesired side effects. To identify alternative anti-infective agents, the present study investigated the antibacterial activity of all-fruit juices derived from blackcurrant, redcurrant, cranberry and raspberry on common oral pathogenic gram-positive and gram-negative bacteria (Streptococcus mutans, Streptococcus gordonii, Streptococcus sobrinus, Actinomyces naeslundii, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Enterococcus faecalis). (2) Methods: Antibacterial efficiency was evaluated by agar diffusion assay and in direct contact with bacteria in planktonic culture. Furthermore, cytotoxicity on human gingival fibroblasts was determined. (3) Results: Blackcurrant juice was most efficient at suppressing bacteria; followed by the activity of redcurrant and cranberry juice.