A Data-Driven Modelling Method for Studying Innovation Processes

Total Page:16

File Type:pdf, Size:1020Kb

A Data-Driven Modelling Method for Studying Innovation Processes Cover Page The handle http://hdl.handle.net/1887/32003 holds various files of this Leiden University dissertation Author: Yuanyuan Zhao Title: Modelling the dynamics of the innovation process : a data-driven agent-based approach Issue Date: 2015-02-17 Modelling the dynamics of the innovation process A data-driven agent-based approach PROEFSCHRIFT ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. mr. C.J.J.M Stolker, volgens besluit van het College voor Promoties te verdedigen op dinsdag 17 februari 2015 klokke 11:15 uur door Yuanyuan Zhao geboren te Zaozhuang, China in 1983 Samenstelling Promotiecommissie Promotor Prof. Dr. B.R. Katzy Co-promotor Dr. R. Ortt (Delft University of Technology) Overige leden Dr. S.W.Cunningham (Delft University of Technology) Prof. Dr. J.N. Kok Prof. Dr. S. Pickl (Universität der Bundeswehr München) Prof. Dr. A. Plaat Prof. Dr. H. J. van den Herik Printed by: Off Page Cover image: Red-crowned crane by Peiduo Cui (崔培铎) 2 To my father 3 Table of Contents Table of Contents ........................................................................................................................ 4 List of Figures............................................................................................................................... 7 List of Tables ................................................................................................................................ 8 1 Introduction ......................................................................................................................... 9 1.1 Motivation ...................................................................................................................11 1.1.1 The importance of innovation ........................................................................11 1.1.2 Decision making on innovation .....................................................................12 1.1.3 The difficulty of collecting data ....................................................................13 1.1.4 The challenge of analysing data ....................................................................14 1.2 Problem statement and research questions ............................................................15 1.3 Research methodology − in-depth case study .......................................................16 1.4 Thesis overview..........................................................................................................18 1.5 References ...................................................................................................................19 2 A Data-driven Modelling Method for Studying Innovation Processes .............. 21 2.1 Challenges of modelling innovation processes .....................................................22 2.2 Overview of research methods for studying innovation processes....................22 2.3 A new data-driven modelling ...................................................................................24 2.4 Illustration: Analysing the Nylon innovation ........................................................28 2.5 Discussion of the data-driven Modelling Method ................................................32 2.6 Conclusion...................................................................................................................39 2.7 References ...................................................................................................................40 3 The Dynamics of Innovation Processes Revisited .................................................... 45 3.1 Advancing innovation process models ...................................................................46 3.2 A review of the linear and cyclical model of innovation ....................................48 3.2.1 The linear innovation model ..........................................................................48 3.2.2 The cyclical innovation model.......................................................................49 3.3 A system view of innovations ..................................................................................50 3.4 Method of the study ...................................................................................................53 3.5 Process pattern in the SSRI data ..............................................................................54 3.5.1 The scientific discovery phase (1950s-1960s) ............................................55 3.5.2 Product development phase (late 1960s-late 1980s) ..................................57 3.5.3 Prozac’s marketing phase (1990s).................................................................60 4 3.5.4 Prozac maturity phase (2001--)......................................................................61 3.6 Discussion ...................................................................................................................63 3.6.1 Linking linear and cyclical model .................................................................63 3.6.2 Theoretical implications..................................................................................65 3.6.3 Managerial implications..................................................................................67 3.7 Conclusions .................................................................................................................68 3.7.1 Answers to RQ2 ...............................................................................................68 3.7.2 Main contributions ...........................................................................................69 3.7.3 Future research .................................................................................................69 3.8 References ...................................................................................................................70 4 The Emergence of Technological Innovations .......................................................... 75 4.1 How to spot emergence? ...........................................................................................76 4.2 What does “emergence” mean? ...............................................................................77 4.3 Can mainstream theories explain emergence? ......................................................79 4.3.1 Life cycle theory...............................................................................................80 4.3.2 Evolutionary theory .........................................................................................80 4.3.3 Punctuated equilibrium theory .......................................................................81 4.3.4 Social construction theory ..............................................................................82 4.3.5 Embedded discussion ......................................................................................82 4.4 A dissipative self-organising model of emergence ..............................................84 4.5 Case study: the Teflon innovation...........................................................................86 4.5.1 Analysis approach ............................................................................................87 4.5.2 The emergence of Teflon ................................................................................89 4.6 Discussion ...................................................................................................................96 4.6.1 Meaning of emergence and the mechanism of emergence .......................97 4.6.2 Added value of the dissipative self-organising model ...............................99 4.6.3 Practical implications ....................................................................................102 4.7 Conclusion.................................................................................................................104 4.8 References .................................................................................................................105 5 A minimal-assumption-based agent-based simulation model of the emergence of technological innovation ....................................................................................................111 5.1 Problems when applying agent-based simulation...............................................112 5.2 Two strategies for simplifying the simulation model ........................................114 5 5.2.1 Using hypercycles as a simplifying mechanis ms .....................................114 5.2.2 Using pre-defined frameworks to categorise activities............................116 5.3 The agent-based model............................................................................................117 5.4 Calibrating the model with an empirical innovation case .................................120 5.4.1 A brief introduction of the Nylon case .......................................................120 5.4.2 Calibrating the simulation model using the Nylon empirics ..................122 5.5 Running the model ...................................................................................................123 5.6 Decision support: scenario design .........................................................................128 5.6.1 Fluctuations .....................................................................................................129 5.6.2 Impact of alternative interventions..............................................................130 5.7 Conclusions and future
Recommended publications
  • Escitalopram
    ESCITALOPRAM Study for Self Portrait, pencil and charcoal on paper, Edgar Degas, 1855 What Edgar does not tell Mary…. That sometimes he cannot sleep at night because he is dreaming of gouache, lithography, pastel, monotype, charcoal, oil, etchings, plates, wax. That he wants to stop and start time at his prerogative so that he can revel in the bounty of materials, van challenge himself and experiment without time passing because the day isn’t long enough. That the circus or the Opera ballet, or the cafe chantants or dinners with friends or the delicious masculine embrace of the racetrack devour his evenings and Sundays but in between there is only work. That some days he looks up and hours have passed and he is late for one thing or another and he races to the cafe or the friends or the theater and what he leaves behind is unfinished work, and he thinks nothing he makes will ever be finished. That he must make careful calculations in order to produce his articles because he is not gifted, he is not prescient, he is not an auteur, he is only a draftsman, a servant, a plodding poseur who wishes to excel. That he is hampered by the infernal blur in his eye he fears will only spread. That the arrangement of legs on a group of dancers or the colour of skirt sashes or the depth of the stage or the bend of a laundress’s back or the line of her apron confounds him and has to be worked and reworked.
    [Show full text]
  • Using a Novel Optogenetic Approach to Directly Assess 5-Ht1a
    Wayne State University Wayne State University Dissertations 1-1-2015 Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment Kelly Marie Mcgregor Wayne State University, Follow this and additional works at: http://digitalcommons.wayne.edu/oa_dissertations Part of the Neurosciences Commons, Pharmacology Commons, and the Psychiatric and Mental Health Commons Recommended Citation Mcgregor, Kelly Marie, "Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment" (2015). Wayne State University Dissertations. Paper 1316. This Open Access Dissertation is brought to you for free and open access by DigitalCommons@WayneState. It has been accepted for inclusion in Wayne State University Dissertations by an authorized administrator of DigitalCommons@WayneState. USING A NOVEL OPTOGENETIC APPROACH TO DIRECTLY ASSESS 5-HT1A SOMATODENDRITIC AUTORECEPTOR FUNCTION IN RESPONSE TO CHRONIC SELECTIVE SEROTONIN REUPTAKE INHIBITOR TREATMENT by KELLY MARIE MCGREGOR DISSERTATION Submitted to the Graduate School of Wayne State University, Detroit, Michigan in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY 2015 MAJOR: PHARMACOLOGY (Molecular Neuropharmacology) Approved By: ________________________________________ Advisor Date ________________________________________ ________________________________________
    [Show full text]
  • Antipsychotics in the Treatment of Autism
    2 Antipsychotics in the Treatment of Autism Carmem Gottfried1,2 and Rudimar Riesgo1,2 1Neuroglial Plasticity Laboratory at Department of Biochemistry, Postgraduate Program of Biochemistry, Institute of Basic Health Sciences, 2Translational Research Group in ASD (GETEA), Child Neurology Unit, Clinical Hospital of Porto Alegre, 1,2Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil 1. Introduction The neurobehavioral syndromes are more frequent than we usually think. They are clinical challenges, because they demand knowledge from the physician as well as time for the correct approach. Such complaints are very frequent in hospital and addition to the private practice. For example, according to a survey carried out in our Hospital, the Child Neurology Unit made 10,622 evaluations in 2010, most of which were neurobehavioral syndromes including autism and other Pervasive Development Disorders. Because of the subtlety of the boundaries between Neurology and Psychiatry, the term neurobehavioral could also be called neuropsychiatric. These boundaries have been explored both in the clinical (Nunes and Mercadante, 2004) and in the experimental area (Quincozes-Santos et al., 2010). It is important to build a bridge between the clinical and the experimental research, especially when the issue is neuropsychiatric disorders. This linkage indubitably enhances the common knowledge of neurobehavioral alterations as well as it promotes the reciprocal enthusiasm. One of the most intriguing neurobehavioral syndromes is autism. The challenge starts with the difficulty of defining the disorder, continues with the limitations imposed by the lack of a clinical marker, and ends with the difficulties in the experimental research field. The word autism was used for the first time by the Swiss psychiatrist Eugen Bleuler in 1911.
    [Show full text]
  • CHAPTER –III a New Methodology for Industrial Synthesis of Antidepressant Drug Desmethylvenlafaxine
    CHAPTER –III A new methodology for industrial synthesis of antidepressant drug Desmethylvenlafaxine. INTRODUCTION: Almost everyone experiences at one time or another, a sense of "feeling low" caused by a disturbing event in one's life but when depression persists, it is a matter of concern. Major depression is a serious condition where a person is not only in a depressed mood but also has a feeling of guilt, hopelessness, loss of interest or pleasure in normal activities including sex, oversleeping or sometimes sleeplessness, extreme fatigue, lack of energy, agitation and sometimes irritability and anxiety. Depression can strike at any age, including childhood. Often, depressed moods can be observed in early middle age as a result of the side effect of medication, hormonal changes (such as before the menstrual period or after child birth), fluctuating blood sugar levels, smoking, environmental factors like chronic exposure to solvents and heavy metals and vitamin deficiencies. Sometimes intestinal overgrowth of yeast (Candida albicans) can precipitate depression. However, the most common time of onset is at old age, that may be a reaction to the fact of growing older, the death of a spouse or close friend, limitations of movement associated with age and impending confrontation with death. Some of the symptoms of depression are poor appetite with weight loss or increased appetite with weight gain, insomnia or hypersomnia, physical hyperactivity or inactivity, loss of interest or pleasure in daily activities, or a decrease in sexual drive. Includes loss of energy or feelings of fatigue, feelings of worthlessness, self-reproach or inappropriate guilt, a diminished ability to think or concentrate and recurrent thoughts of death or suicide.
    [Show full text]
  • Laughing Gas, Viagra, and Lipitor
    Laughing Gas, Viagra, and Lipitor The Human Stories Behind the Drugs We Use Jie Jack Li 1 2006 3 Oxford University Press, Inc., publishes works that further Oxford University’s objective of excellence in research, scholarship, and education. Oxford New York Auckland Cape Town Dar es Salaam Hong Kong Karachi Kuala Lumpur Madrid Melbourne Mexico City Nairobi New Delhi Shanghai Taipei Toronto With offices in Argentina Austria Brazil Chile Czech Republic France Greece Guatemala Hungary Italy Japan Poland Portugal Singapore South Korea Switzerland Thailand Turkey Ukraine Vietnam Copyright © 2006 by Oxford University Press Published by Oxford University Press, Inc. 198 Madison Avenue, New York, New York 10016 www.oup.com Oxford is a registered trademark of Oxford University Press All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of Oxford University Press. Library of Congress Cataloging-in-Publication Data Li, Jie Jack. Laughing gas, viagra, and lipitor : the human stories behind the drugs we use / Jie Jack Li. p. cm. Includes bibliographical references and index. ISBN-13 978-0-19-530099-4 ISBN 0-19-530099-8 1. Drugs—Miscellanea. 2. Nitrous oxide. 3. Sildenafil. I. Title. RM301.15.L5 2006 362.29'9—dc22 2006002586 987654321 Printed in the United States of America on acid-free paper foreword ny person interested in understanding the history of medical A progress and the way in which many of the most important medi- cines came into existence will be well rewarded by reading this latest book by Jie Jack Li, one of the most prolific and interesting authors in the field of molecular medicine and chemistry.
    [Show full text]
  • 'Let Them Eat Prozac'
    The SSRI Issues In the course of the 1990s, the antidepressant group of drugs known as the SSRIs – Selective Serotonin Reuptake Inhibitors – Prozac, Zoloft and Paxil became household names. These drugs came from obscurity to being among the best-known drugs on the planet. But where antibiotics removed certain diseases completely, in the 1990s we have become more depressed. With the SSRIs, we entered an Age of Depression despite the existence of these “happiness” pills. There is no account of what has been happening to us during this period, even though the SSRIs have given rise to a new language in which we understand ourselves – a biobabble to replace the psychobabble of Freudian terms that so coloured our identities during the 20th Century. These drugs have given rise to hundreds of legal actions following suicides and homicides, one of which the Tobin versus SmithKline case resulted in a first ever finding against a pharmaceutical company for a psychiatric side-effect of a psychotropic drug. In addition, the spectre of dependence hangs over these drugs, with a recently filed class action for physical dependence on Paxil/Seroxat. These drugs have also appeared to play a central part in a growing set of issues in the world of academic medicine, surrounding academic freedom and the changing face of the scientific literature. There are increasing concerns that a considerable proportion of the therapeutics literature may be ghost written and in general that the data from clinical trials, which is voluntarily contributed by the patients seeking healthcare, has become the property of pharmaceutical companies.
    [Show full text]
  • Histopathology on the Vital Organs of Antidepressant Treated Rats
    Histopathology on the vital organs of antidepressant treated Rats. Report of the UGC Minor Research Project Submitted By Ms. Achary Bindu Assistant Professor in Zoology Ramniranjan Jhunjhunwala College Ghatkopar (W), Mumbai 400 086. To University Grants Commission Western Regional Office Ganesh Khind, Pune 411 007. 1 INTRODUCTION: Depression is a medical disorder of the brain that affects feelings, thoughts, behaviors and physical health of a person. The World Health Organization (WHO) figures reveal that currently over 450 million people in the society are directly affected by mental disorders or disabilities, most of who live in developing countries. Almost 80% of people who see physicians are depressed (Escobar et al., 1987; Lipowski 1987; Barsky 1995). About 41% of depressed women are too embarrassed to seek help. Thus the life-time risk of developing depression is 10-20% in females and slightly less in males. In terms of sociodemographic variables, studies in Indian population have shown that depression is more common in women than men (Bagadia et al., 1973, Sethi B.B and Prakash R., 1979, Nandi et al., 1979, Ramachandran et al., 1982, Poongothai et al., 2009). Gender differences in depression have been due to biological factor (Parker G, Brotchie H., 2010). In view of the morbidity, depression as a disorder has always been a focus of attention of researchers in India. Up to 15% of those who are clinically depressed die by suicide. Thus depression, if untreated, may lead to suicide. Antidepressants are drugs that relieve the symptoms of depression. The term ‘antidepressant’ is sometimes applied to any therapy (e.g.
    [Show full text]
  • Drugs Affecting 5-HT Systems
    DRUGS AFFECTING 5-HT SYSTEMS The transcript of a Witness Seminar held by the History of Modern Biomedicine Research Group, Queen Mary, University of London, on 20 November 2012 Edited by C Overy and E M Tansey Volume 47 2013 ©The Trustee of the Wellcome Trust, London, 2013 First published by Queen Mary, University of London, 2013 The History of Modern Biomedicine Research Group is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 0 90223 887 9 All volumes are freely available online at www.history.qmul.ac.uk/research/modbiomed/ wellcome_witnesses/ Please cite as: Overy C, Tansey E M. (eds) (2013) Drugs Affecting 5-HT Systems. Wellcome Witnesses to Contemporary Medicine, vol. 47. London: Queen Mary, University of London. CONTENTS What is a Witness Seminar v Acknowledgements E M Tansey and C Overy vii Illustrations and credits ix Abbreviations xi Ancillary guides xiii Introduction E M Tansey xv Transcript Edited by C Overy and E M Tansey 1 Appendix 1 Pioneering research by SmithKline Beecham: 5-HT3 receptor antagonism and anti-emetic activity Professor Gareth Sanger 139 Biographical notes 141 References 159 Index 187 Witness Seminars: Meetings and Publications 203 WHAT IS A WITNESS SEMINAR? The Witness Seminar is a specialized form of oral history, where several individuals associated with a particular set of circumstances or events are invited to meet together to discuss, debate, and agree or disagree about their memories. The meeting is recorded, transcribed and edited for publication. This format was first devised and used by the Wellcome Trust’s History of Twentieth Century Medicine Group in 1993 to address issues associated with the discovery of monoclonal antibodies.
    [Show full text]
  • Read Now (Pdf)
    Case Histories of Significant Medical Advances: SSRIs and non-SSRIs (through 1999) Amar Bhidé Srikant Datar Katherine Stebbins Working Paper 20-135 Case Histories of Significant Medical Advances: SSRIs and Non-SSRIs (through 1999) Amar Bhidé Harvard Business School Srikant Datar Harvard Business School Katherine Stebbins Harvard Business School Working Paper 20-135 Copyright © 2020, 2021 Amar Bhidé, Srikant Datar, and Katherine Stebbins. Working papers are in draft form. This working paper is distributed for purposes of comment and discussion only. It may not be reproduced without permission of the copyright holder. Copies of working papers are available from the author. Funding for this research was provided in part by Harvard Business School. Case Histories of Significant Medical Advances SSRIs and Non-SSRIs (‘Prozac’ through 1999) Amar Bhidé, Harvard Business School Srikant Datar, Harvard Business School Katherine Stebbins, Harvard Business School Abstract: Our case history describes the development of Prozac, a blockbuster drug that transformed the treatment of depression – and became a cultural phenomenon in the United States. Specifically, we chronicle the: 1) prior treatments for depression and the research that provided a foundation for Prozac, before 1970; 2) development of Prozac, from 1971 to 1987; and 3) rapid adoption in the US after 1988. Note: Prozac, like the other innovations in this series of case-histories, is included in a list compiled by Victor Fuchs and Harold Sox (2001) of technologies produced (or significantly advanced) between 1975 and 2000 that internists in the United States said had had a major impact on patient care. The case histories focus on advances in the 20th century (i.e.
    [Show full text]