Positron Emission Tomography (PET/CT) Scan the PET/CT Is a Scan That Shows the Size, Shape and Position of the Organs in Your Body
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Submission to the Nuclear Power Debate Personal Details Kept Confidential
Submission to the Nuclear power debate Personal details kept confidential __________________________________________________________________________________________ Firstly I wish to say I have very little experience in nuclear energy but am well versed in the renewable energy one. What we need is a sound rational debate on the future energy requirements of Australia. The calls for cessation of nuclear investigations even before a debate begins clearly shows that emotion rather than facts are playing a part in trying to stop the debate. Future energy needs must be compliant to a sound strategy of consistent, persistent energy supply. This cannot come from wind or solar. Lets say for example a large blocking high pressure weather system sits over the Victorian, NSW land masses in late summer- autumn season. We will see low winds for anything up to a week, can the energy market from the other states support the energy needs of these states without coal or gas? I think not. France has a large investment in nuclear energy and charges their citizens around half as much for it than Germany. Sceptics complain about the costs of storage of waste, they do not suggest what is going to happen to all the costs to the environment when renewing of derelict solar panels and wind turbine infrastructure which is already reaching its use by dates. Sceptics also talk about the dangers of nuclear energy using Chernobyl, Three Mile Island and Fuklushima as examples. My goodness given that same rationale then we should have banned flight after the first plane accident or cars after the first car accident. -
Members | Diagnostic Imaging Tests
Types of Diagnostic Imaging Tests There are several types of diagnostic imaging tests. Each type is used based on what the provider is looking for. Radiography: A quick, painless test that takes a picture of the inside of your body. These tests are also known as X-rays and mammograms. This test uses low doses of radiation. Fluoroscopy: Uses many X-ray images that are shown on a screen. It is like an X-ray “movie.” To make images clear, providers use a contrast agent (dye) that is put into your body. These tests can result in high doses of radiation. This often happens during procedures that take a long time (such as placing stents or other devices inside your body). Tests include: Barium X-rays and enemas Cardiac catheterization Upper GI endoscopy Angiogram Magnetic Resonance Imaging (MRI) and Magnetic Resonance Angiography (MRA): Use magnets and radio waves to create pictures of your body. An MRA is a type of MRI that looks at blood vessels. Neither an MRI nor an MRA uses radiation, so there is no exposure. Ultrasound: Uses sound waves to make pictures of the inside of your body. This test does not use radiation, so there is no exposure. Computed Tomography (CT) Scan: Uses a detector that moves around your body and records many X- ray images. A computer then builds pictures or “slices” of organs and tissues. A CT scan uses more radiation than other imaging tests. A CT scan is often used to answer, “What does it look like?” Nuclear Medicine Imaging: Uses a radioactive tracer to produce pictures of your body. -
HISTORY Nuclear Medicine Begins with a Boa Constrictor
HISTORY Nuclear Medicine Begins with a Boa Constrictor Marshal! Brucer J Nucl Med 19: 581-598, 1978 In the beginning, a boa constrictor defecated in and then analyzed the insoluble precipitate. Just as London and the subsequent development of nuclear he suspected, it was almost pure (90.16%) uric medicine was inevitable. It took a little time, but the acid. As a thorough scientist he also determined the 139-yr chain of cause and effect that followed was "proportional number" of 37.5 for urea. ("Propor inexorable (7). tional" or "equivalent" weight was the current termi One June week in 1815 an exotic animal exhibi nology for what we now call "atomic weight.") This tion was held on the Strand in London. A young 37.5 would be used by Friedrich Woehler in his "animal chemist" named William Prout (we would famous 1828 paper on the synthesis of urea. Thus now call him a clinical pathologist) attended this Prout, already the father of clinical pathology, be scientific event of the year. While he was viewing a came the grandfather of organic chemistry. boa constrictor recently captured in South America, [Prout was also the first man to use iodine (2 yr the animal defecated and Prout was amazed by what after its discovery in 1814) in the treatment of thy he saw. The physiological incident was common roid goiter. He considered his greatest success the place, but he was the only person alive who could discovery of muriatic acid, inorganic HC1, in human recognize the material. Just a year earlier he had gastric juice. -
The Supply of Medical Isotopes
The Supply of Medical Isotopes AN ECONOMIC DIAGNOSIS AND POSSIBLE SOLUTIONS The Supply of Medical Isotopes AN ECONOMIC DIAGNOSIS AND POSSIBLE SOLUTIONS The Supply of Medical Isotopes AN ECONOMIC DIAGNOSIS AND POSSIBLE SOLUTIONS This work is published under the responsibility of the Secretary-General of the OECD. The opinions expressed and arguments employed herein do not necessarily reflect the official views of OECD member countries. This document, as well as any data and any map included herein, are without prejudice to the status of or sovereignty over any territory, to the delimitation of international frontiers and boundaries and to the name of any territory, city or area. Please cite this publication as: OECD/NEA (2019), The Supply of Medical Isotopes: An Economic Diagnosis and Possible Solutions, OECD Publishing, Paris, https://doi.org/10.1787/9b326195-en. ISBN 978-92-64-94550-0 (print) ISBN 978-92-64-62509-9 (pdf) The statistical data for Israel are supplied by and under the responsibility of the relevant Israeli authorities. The use of such data by the OECD is without prejudice to the status of the Golan Heights, East Jerusalem and Israeli settlements in the West Bank under the terms of international law. Photo credits: Cover © Yok_onepiece/Shutterstock.com. Corrigenda to OECD publications may be found on line at: www.oecd.org/about/publishing/corrigenda.htm. © OECD 2019 You can copy, download or print OECD content for your own use, and you can include excerpts from OECD publications, databases and multimedia products in your own documents, presentations, blogs, websites and teaching materials, provided that suitable acknowledgement of OECD as source and copyright owner is given. -
Radioactive Waste
Radioactive Waste 07/05/2011 1 Regulations 2 Regulations 1. Nuclear Regulatory Commission (NRC) 10 CFR 20 Subpart K. Various approved options for radioactive waste disposal. (See also Appendix F) 10 CFR 35.92. Decay in storage of medically used byproduct material. 10 CFR 60. Disposal of high-level wastes in geologic repositories. 10 CFR 61. Shallow land disposal of low level waste. 10 CFR 62. Criteria and procedures for emergency access to non-Federal and regional low-level waste disposal facilities. 10 CFR 63. Disposal of high-level rad waste at Yucca Mountain, NV 10 CFR 71 Subpart H. Quality assurance for waste packaging and transportation. 10 CFR 72. High level waste storage at an MRS 3 Regulations 2. Department of Energy (DOE) DOE Order 435.1 Radioactive Waste Management. General Requirements regarding radioactive waste. 10 CFR 960. General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. Site selection guidelines for a waste repository. The following are not regulations but they provide guidance regarding the implementation of DOE Order 435.1: DOE Manual 435.1-1. Radioactive Waste Management Manual. Describes the requirements and establishes specific responsibilities for implementing DOE O 435.1. DOE Guide 435.1-1. Suggestions and acceptable ways of implementing DOE M 435.1-1 4 Regulations 3. Environmental Protection Agency 40 CFR 191. Environmental Standards for the Disposal of Spent Nuclear Fuel, High-level and Transuranic Radioactive Wastes. Protection for the public over the next 10,000 years from the disposal of high-level and transuranic wastes. 4. Department of Transportation 49 CFR Parts 171 to 177. -
Fission-Produced 99Mo Without a Nuclear Reactor
BRIEF COMMUNICATIONS Fission-Produced 99Mo Without a Nuclear Reactor Amanda J. Youker, Sergey D. Chemerisov, Peter Tkac, Michael Kalensky, Thad A. Heltemes, David A. Rotsch, George F. Vandegrift, John F. Krebs, Vakho Makarashvili, and Dominique C. Stepinski Argonne National Laboratory, Nuclear Engineering Division, Argonne, Illinois halted in the past due to inclement weather, natural phenomena, 99Mo, the parent of the widely used medical isotope 99mTc, is cur- flight delays, and terrorist threats (6). rently produced by irradiation of enriched uranium in nuclear reac- The predominant global 99Mo production route is irradiation of tors. The supply of this isotope is encumbered by the aging of these highly enriched uranium (HEU, $20% 235U) solid targets in nuclear reactors and concerns about international transportation and nu- reactors fueled by uranium (2). Other potential 99Mo production Methods: clear proliferation. We report results for the production paths include (n,g)98Mo and (g,n)100Mo; however, both routes re- of 99Mo from the accelerator-driven subcritical fission of an aqueous quire enriched molybdenum material and produce low-specific- solution containing low enriched uranium. The predominately fast 99 neutrons generated by impinging high-energy electrons onto a tan- activity Mo, which cannot be loaded directly on a commercial 99m talum convertor are moderated to thermal energies to increase fission Tc generator. The U.S. National Nuclear Security Administra- processes. The separation, recovery, and purification of 99Mo were tion implements the long-standing U.S. policy to minimize and demonstrated using a recycled uranyl sulfate solution. Conclusion: eliminate HEU in civilian applications by working to convert re- The 99Mo yield and purity were found to be unaffected by reuse of the search reactors and medical isotope production facilities to low previously irradiated and processed uranyl sulfate solution. -
ICD-10: Clinical Concepts for Internal Medicine
ICD-10 Clinical Concepts for Internal Medicine ICD-10 Clinical Concepts Series Common Codes Clinical Documentation Tips Clinical Scenarios ICD-10 Clinical Concepts for Internal Medicine is a feature of Road to 10, a CMS online tool built with physician input. With Road to 10, you can: l Build an ICD-10 action plan customized l Access quick references from CMS and for your practice medical and trade associations l Use interactive case studies to see how l View in-depth webcasts for and by your coding selections compare with your medical professionals peers’ coding To get on the Road to 10 and find out more about ICD-10, visit: cms.gov/ICD10 roadto10.org ICD-10 Compliance Date: October 1, 2015 Official CMS Industry Resources for the ICD-10 Transition www.cms.gov/ICD10 1 Table Of Contents Common Codes • Abdominal Pain • Headache • Acute Respiratory Infections • Hypertension • Back and Neck • Pain in Joint Pain (Selected) • Pain in Limb • Chest Pain • Other Forms of • Diabetes Mellitus w/o Heart Disease Complications Type 2 • Urinary Tract • General Medical Examination Infection, Cystitis Clinical Documentation Tips • Acute Myocardial • Diabetes Mellitus, Infarction (AMI) Hypoglycemia and • Hypertension Hyperglycemia • Asthma • Abdominal Pain and Tenderness • Underdosing Clinical Scenarios • Scenario 1: Follow-Up: • Scenario: Cervical Kidney Stone Disc Disease • Scenario 2: Epigastric Pain • Scenario: Abdominal Pain • Scenario 3: Diabetic • Scenario: Diabetes Neuropathy • Scenario: ER Follow Up • Scenario 4: Poisoning • Scenario: COPD with -
Radiopharmacy Introduction
Radiopharmacy Introduction This Chapter is an amended version of the Good Radiopharmacy Practice Position Paper (GRPP), prepared as a policy document by the SIG Radiopharmacy and Nuclear Medicine of the Netherlands Association of Hospital Pharmacists (NVZA). Introduction In practice, Healthcare Inspectorate (IGZ) inspections in hospitals identify issues during the preparation and reconstitution and/ or aseptic handling (RAH) of radiopharmaceuticals in relation to the interpretation and application of the Dutch Good Manufacturing Practice for hospitals (GMP-z) guidelines. This Chapter aims to provide an unambiguous framework to ensure that there is no doubt about the guidelines and circumstances that apply to every situation. Principles, legislation and regulations In the Netherlands, around 65 hospitals have a Nuclear Medicine Department. More than 50% of these Departments are currently supplied by one of the three radiopharmacies of GE Healthcare. In the other hospitals, the radiopharmaceuticals are prepared by the Radiopharmacy, as well known as the “hot lab”. As this generally concerns centers with a major Nuclear Medicine Department, it can be said that the largest volume of radiopharmaceuticals is produced in the hospitals themselves. Radionuclides and radiopharmaceuticals are also purchased ready-made and are prepared for administration by the hot lab. Radiopharmaceuticals are ordinary pharmacy preparations, but differ from other prepared medicines due to their small-scale preparation (always prepared shortly before for administration (PFA)) on a patients name, sometimes preceded by a labelling step with a radionuclide generated in-house or not), their short shelf-life (due to radioactive decay) and the low pharmacological doses that are generally used. The radiation dose for the patient is generally low, as most radiopharmaceuticals are used for diagnostic purposes. -
Breast CT: a New Alternative to Mammography University of California, Davis (UC Davis)
Breast CT: A New Alternative To Mammography University of California, Davis (UC Davis) Computed tomography (CT) is used extensively to identify tumors and other abnormalities in the brain, abdomen and pelvis. In contrast to medical X-rays, which produce a single-layer 2-D image, a CT scan records hundreds of images of multiple tissue layers and assembles them into a 3-D representation. A team working at University of California Davis Cancer Center has developed a breast CT device they believe provides a more comfortable and potentially more sensitive alternative to X-ray based mammography to detect breast cancer. The breast CT device, currently in a Phase II investigational trial, is the invention of Drs. John Boone, professor of radiology at UC-Davis, and Thomas R. Nelson, professor of radiology at University of California, San Diego. CT has not typically been applied to breast cancer detection because of concerns over the radiation dose required. The inventors solved this problem by designing a CT device that scans each breast while the patient lies face down on a special table. The radiation exposure in the breast is equivalent to that of a traditional mammogram, and the thoracic cavity is not irradiated at all, as it would be in a conventional CT scanner. The first 21 patients in the ongoing clinical trial reported that the CT breast scan, which does not require breast compression, caused them less discomfort than mammography. The CT detected 19 of the 21 tumors initially identified by mammography, and Dr. Lindfors believes the prototype machine and method of scanning can be modified to improve on this detection rate. -
Learn More About X-Rays, CT Scans and Mris (Pdf)
What is the difference between X-Rays, CT Scans, and MRIs? X-Rays are a form of electromagnetic radiation, like light. They are less energetic than gamma rays, and more energetic than ultraviolet light. Because they pass easily through soft tissue, like organs and muscles, but not so easily through hard tissue like bones and teeth, we are most familiar with them being used to look at skeletal structures. Sometimes a person ingests or has injected an X-ray opaque fluid that will fill a space of interest for X-ray imaging. This is called an angiogram. A nuclear scan uses an injected gamma ray emitting substance that accumulates in the organ of interest and a special camera records the gamma rays. A CT Scan is usually a series of X-rays taken from different directions that are then assembled into a three dimensional model of the subject in a computer. CT stands for computed tomography, and tomography means a picture of a slice. Where an X-ray may show edges of soft tissues all stacked on top of each other, the computer in a CT scan can figure out how those edges relate to each other in depth, and so the image has much more soft tissue usability. Another kind of CT scan uses positrons. I have to mention this because positrons are antimatter electrons (Yes, antimatter does exist and it is useful!) In Positon Emission Tomography (PET) a positron emitting radionuclide (radioactive material) is attached to a metabolically useful molecule. This is introduced to the tissue, and as emitted positrons decompose they emit gamma rays which can be traced by the machine and computer back to their points of origin, and an image is formed. -
III.2. POSITRON EMISSION TOMOGRAPHY – a NEW TECHNOLOGY in the NUCLEAR MEDICINE IMAGE DIAGNOSTICS (Short Review)
III.2. POSITRON EMISSION TOMOGRAPHY – A NEW TECHNOLOGY IN THE NUCLEAR MEDICINE IMAGE DIAGNOSTICS (Short review) Piperkova E, Georgiev R Dept.of Nuclear Medicine and Dept of Radiotherapy, National Oncological Centre Hospital, Sofia Positron Emission Tomography (PET) is a technology which makes fast advance in the field of Nuclear Medicine. It is different from the X-ray Computed Tomography and Magnetic Resonance Imaging (MRI), where mostly anatomical structures are shown and their functioning could be evaluated only indirectly. In addition, PET can visualise the biological nature and metabolite activity of the cells and tissues. It also has the capability for quantitative determination of the biochemical, physiological and pathological process in the human body (1). The spatial resolution of PET is usually 4-5mm and when the concentration of the positron emitter in the cells is high enough, it allows to see small size pathological zones with high proliferative and metabolite activity ( 3, 7, 17). Following fast and continuous improvement, PET imaging systems have advanced from the Bismuth Germanate Oxide (BGO) circular detector technology to the modern Lutetium Orthosilicate (LSO) and Gadolinium Orthosilicate (GSO) detectors (2, 7, 16). On the other hand, the construction technology has undergone significant progress in the development of new combined PET-CT and PET-MRI systems which currently replace the conventional PET systems with integrated transmission and emission detecting procedures, shown in Fig. 1. Fig. 1 A modern PET-CT system with one gantry. The sensitivity and the accuracy of PET based methods are found to be considerably higher compared to the other existing imaging methods and they can achieve 90-100% in the localisation of different oncological lesions (4, 11, 13, 14). -
Positron Emission Tomography
Positron emission tomography A.M.J. Paans Department of Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, The Netherlands Abstract Positron Emission Tomography (PET) is a method for measuring biochemical and physiological processes in vivo in a quantitative way by using radiopharmaceuticals labelled with positron emitting radionuclides such as 11C, 13N, 15O and 18F and by measuring the annihilation radiation using a coincidence technique. This includes also the measurement of the pharmacokinetics of labelled drugs and the measurement of the effects of drugs on metabolism. Also deviations of normal metabolism can be measured and insight into biological processes responsible for diseases can be obtained. At present the combined PET/CT scanner is the most frequently used scanner for whole-body scanning in the field of oncology. 1 Introduction The idea of in vivo measurement of biological and/or biochemical processes was already envisaged in the 1930s when the first artificially produced radionuclides of the biological important elements carbon, nitrogen and oxygen, which decay under emission of externally detectable radiation, were discovered with help of the then recently developed cyclotron. These radionuclides decay by pure positron emission and the annihilation of positron and electron results in two 511 keV γ-quanta under a relative angle of 180o which are measured in coincidence. This idea of Positron Emission Tomography (PET) could only be realized when the inorganic scintillation detectors for the detection of γ-radiation, the electronics for coincidence measurements, and the computer capacity for data acquisition and image reconstruction became available. For this reason the technical development of PET as a functional in vivo imaging discipline started approximately 30 years ago.