1 Infectious Pancreatic Necrosis Virus Arun K
1 Infectious Pancreatic Necrosis Virus ARUN K. DHAR,1,2* SCOTT LAPATRA,3 ANDREW ORRY4 AND F.C. THOMas ALLNUTT1 1BrioBiotech LLC, Glenelg, Maryland, USA; 2Aquaculture Pathology Laboratory, School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona, USA; 3Clear Springs Foods, Buhl, Idaho, USA; 4Molsoft, San Diego, California, USA 1.1 Introduction and as a genome-linked protein, VPg, via guany- lylation of VP1 (Fig. 1.1 and Table 1.1). Infectious pancreatic necrosis virus (IPNV), the aetio- Aquabirnaviruses have broad host ranges and logical agent of infectious pancreatic necrosis (IPN), differ in their optimal replication temperatures. is a double-stranded RNA (dsRNA) virus in the fam- They consist of four serogroups A, B, C and D ily Birnaviridae (Leong et al., 2000; ICTV, 2014). (Dixon et al., 2008), but most belong to serogroup The four genera in this family include Aquabirnavirus, A, which is divided into serotypes A1–A9.The A1 Avibirnavirus, Blosnavirus and Entomobirnavirus serotype contains most of the US isolates (reference (Delmas et al., 2005), and they infect vertebrates and strain West Buxton), serotypes A2–A5 are primar- invertebrates. Aquabirnavirus infects aquatic species ily European isolates (reference strains, Ab and (fish, molluscs and crustaceans) and has three spe- Hecht) and serotypes A6–A9 include isolates from cies: IPNV, Yellowtail ascites virus and Tellina virus. Canada (reference strains C1, C2, C3 and Jasper). IPNV, which infects salmonids, is the type species. The IPNV genome consists of two dsRNAs, segments A and B (Fig. 1.1; Leong et al., 2000). Segment A 1.1.1 IPNV morphogenesis has ~ 3100 bp and contains two partially overlap- ping open reading frames (ORFs).
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