Redistribution of the Corneal Epithelium After Overnight Wear of Orthokeratology Contact Lenses for Myopia Reduction Ju Zhang Shandong Eye Hospital Jing Li Shandong Eye Hospital Xiaofeng Li Shandong Eye Hospital Fengjie Li Shandong Eye Hospital Ting Wang (
[email protected] ) Research Article Keywords: orthokeratology, corneal epithelium, thickness, FD-OCT Posted Date: January 4th, 2019 DOI: https://doi.org/10.21203/rs.2.104/v2 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Version of Record: A version of this preprint was published at Contact Lens and Anterior Eye on June 1st, 2020. See the published version at https://doi.org/10.1016/j.clae.2020.02.015. Page 1/12 Abstract Background: To investigate changes in the corneal epithelium topographic map in juvenile myopia after overnight wear of orthokeratology lenses (OK). Methods: A total of 53 juveniles (53 right eyes) successfully wore OK and were reviewed in a timely manner from January 2016 to July 2017. Epithelial and corneal data were obtained by optical coherence tomography (OCT). Changes in uncorrected visual acuity, diopter, corneal refractive power, and epithelial and corneal thickness were analyzed before and after 1 day, 1 week, and 1 mo of overnight wear of OK. Results: The corneal epithelium was reshaped after 1 day of OK; the myopia degree was reduced, and uncorrected visual acuity reached 0 logMAR at 1 week. The central (2-mm) average epithelial thickness was 52.04±2.35 μm, 49.25±2.67 μm, 45.91±2.80 μm, and 47.53±3.44 μm before and after 1 day, 1 week, and 1 mo of OK, respectively (t=10.122, 10.782, and 10.673, respectively, P≤0.001).