DOCSLIB.ORG

Annual Report 2017

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Annual Report 2017 CENTER OF NEUROLOGY TÜBINGEN Annual Report 2017 APPENDIX Content ANNUAL REPORT 2017 Appendix U NIVERSITY HOSPITAL OF NEUROLOGY DEPARTMENT OF NEUROLOGY WITH NEUROVASCULAR MEDICINE AND NEURO-ONCOLOGY DEPARTMENT OF NEUROLOGY AND EPILEPTOLOGY DEPARTMENT OF NEURODEGENERATIVE DISEASES DEPARTMENT OF COGNITIVE NEUROLOGY DEPARTMENT OF CELLULAR NEUROLOGY INDEPENDENT RESEARCH GROUPS PUBLICATIONS AND STUDENT TRAINING IN 2017 University Hospital of Neurology Clinical Staff WARD 46 WARD 43 Diana Arko Luther Basa HEAD OF NURSING SERVICES Annette Eisele Meike Besser Karl Andrew Gallar Önder Bilen Dr. Renate D. Fuhr Joann Gallo Roslyn Chin (Head of Nursing Services) Corinna Kalmbach Friedhelm Chmell Gabriele Kern-Braun Michelle Dupke Doris Stenske-Bader Renate Maier-Korneck Rebecca Fais (Deputy Head of Nursing Services) Bettina Mollenhauer Maria Flohr Lisa Nickel Jay Carl Garcia Adriana Hurcikova Iris Sadowski Alice Hoffmann (Division Manager, Ward 46/24/27) Sarah Schneider Tobias Illhardt Ulrike Schweizer Eva Kern Olga Krämer Gudrun Siegl Dorothe Pacholleck (Deputy Division Manager, Birgit Weimar Nicole Steiner Ward 46/24/27) Sina Westbomke Christine Reuter (Ward Manager, Ward 20) Gerda Weise (Deputy Ward Manager, 20) 4 ANNUAL REPORT 2017 WaRD 44 WaRD 45 CASE/OCCUPANCY INTENSIVE CaRE/ MANAGEMENT STROKE UNIT Jane Buo Johanna Eisele Silvia Clement Andrea Albrecht Isaac Emwinghare Christine Rebenschütz Nina Begemann Tatjana Graz Christina Tomschitz Karin Brunner Fatima Hammami Isabel Utsch-Selinow Abrar Döger Werner Hansen Laura Gabriele Sigrid Herter Tobias Göttermann Michael Heymann TECHNICIANS Susanne Grumann Sevbenur Ibrahimova Carmen Haag Beate Kloster Margarete Dengler (Nurse) Frank Hauber Andrea Langmann Anke Deutsch (EP) Kathrin Haug Annika Löweke Evelyn Dubois (CFS Chemistry) Marc-Sebastian Haug Kevin Lux Irina Köhnlein (Nurse) Stefanie Herholz Alisa Mansour-Tokovic Renate Mahle (EEG Neurosonography) Regina Johner Banu Sahin Yvonne Schütze Sandra Kästner Katrin Schindl (Neurosonography, EP) Petra Kaschowitz Karola Schweinbenz Veronika Serwotka (Nerve conduction) Lothar Kunz Anja Siegle Elke Stransky (CSF Chemistry) Ines Lange Zoe Weigel Deborah Tünnerhoff-Barth Christine Löffler Katharina Wehner (Nerve conduction) Giusi Marchese Nadine Wolter Nathalie Vetter Christine Moosmann (ENG Neurosonography) Birgit Moryson Kathrin Vohrer (EEG, EP) Markus Müller NURSING ASSISTANTS Barbara Wörner (EEG) Petra Nipprasch Claudia Romeikat Tamazur Allouch Thomas Rottmann Leonie Czech SECRETARIES Mirjam Schafer Lisa Hermann Johann Schmuck Christopher Kübler Ina Baumeister Lena Seelmann Gabriele Layla Dr. Patricia Beck Brigitte Steinau Emely Paul Jutta Eymann Tanja Striebich Carolin Schmitt Dagmar Heller-Schmerold Gudrun Wamsler-Lutz Maritta Weipert Isolde Marterer Angelika Weber Christine Riegraf Bettina Weisser Susanne Stimmler Eva Wener-Buck WARD ASSISTANTS Diana Thomma Dieter Zeller Doris Wieder Michelle Zimmermann Nicole Braun Ulrike Zimmermann Simone Dettinter Stefanie Müllerschön MEDICAL DOCUMENTATION Sandra Sailer Christine Brick Horst Feuerbacher Dr. Katharina Friebe Martina Pabst 5 Department of Neurology with Neurovascular Medicine and Neuro-Oncology Clinical and Scientifi c Staff SCIENTISTS/RESIDENTS David Baur (since 03/2017) HEAD OF THE DEPARTMENT Dr. Paolo Belardinelli Dr. Til Ole Bergmann Prof. Dr. Ulf Ziemann Dr. Corinna Blum Dr. Susanne Dietrich Mohamed Yasser Elnaggar GROUP LEADERS/ATTENDING PHYSICIANS Irina Gepfner-Tuma Dr. Felix Geser (01-06/2017) Prof. Dr. Hermann Ackermann Dr. Pedro Caldana Gordon (since 09/2017) Dr. Rainer Greulich (Cardiologist) Dr. Parameswari Govindarajan Dr. Markus Kowarik (since 11/2017) Florian Härtig Dr. Markus Krumbholz Prof. Dr. Ingo Hertrich Dr. Annerose Mengel (since 05/2017) Dr. Marilin Koch Dr. Florian Müller-Dahlhaus (10% after 07/2016) Noemi Maros (since 02/2017) Prof. Dr. Ulrike Naumann Magdalena Mrozek (05-11/2017) Dr. Sven Poli, MSc Khouloud Nafaa (since 07/2017) Dr. Johannes Rieger (5%) Dr. Margarethe Paech (50%) Dr. Dennis Schlak (50%) Dr. Justyna Przystal Prof. Dr. Dr. Ghazaleh Tabatabai Elisabeth Rexer (Interdisciplinary Division of Neuro-Oncology) Dr. Hardy Richter Dr. Christina Roggia Dr. Christoph Ruschil Dr. Natalie Schaworonkow (since 12/2017) Vera Stadler (since 03/2017) Maria-Ioanna Stefanou Dr. Mihály Sulyok (since 12/2017) Johannes Tünnerhoff Charlotte Weyland (until 11/2017) Dr. Martin Wolf (until 02/2017) Dr. Lena Zeltner (until 11/2016) Dr. Carl Moritz Zipser (until 03/2017) Dr. Brigitte Zrenner Dr. Christoph Zrenner 6 ANNUAL REPORT 2017 TICECHN AL STAFF/ADMINISTRATION MEDICAL DOCTORAL STUDENTS Dipl.-Ing. Rüdiger Berndt (Electronics, Abdullah Alekuzei (Supervisor Prof. Dr. Naumann) together with the Dept. of Cognitive Neurology) Hannes Becker (Supervisor Prof. Dr. Dr. Tabatabai) Marcel Armbruster (since 04/2017) Elina Brendle (Supervisor Prof. Dr. Dr. Tabatabai) Sabrina Baumeister Elena Dangel (Supervisor Prof. Dr. Dr. Tabatabai) Evelyn Dubois Hulda Ewald (Supervisor Prof. Dr. Dr. Tabatabai) Sandra Gäßler-Kegelmann, MBa (since 04/2017) Juliane Ebert (Supervisor Prof. Dr. Dr. Tabatabai) Sarah Hendel Jakob Ehlers (Supervisor Prof. Dr. Naumann) Marion Jeric Hanna Faber (Supervisor Prof. Dr. Ziemann) Anna Kempf Ines Fachner (Supervisor Prof. Dr. Dr. Tabatabai) Gabriele Kuebart Oliver Föhst (Supervisor Prof. Dr. Dr. Tabatabai) Kerstin Sahlmann (02-09/2017) Katharina Hadaschik Matthias Scholl (since 10/2017) (Supervisors Prof. Dr. Ziemann, Dr. Poli) Elke Stransky Mona Hirt (Supervisor Prof. Dr. Dr. Tabatabai) Julia Zeller Ilona Hoberg (Supervisor PD Dr. Bischof) Yeho-Irae Kim (Supervisor Prof. Dr. Ziemann) Julia Elisabeth Király (Supervisor Prof. Dr. Ziemann) PHD STUDENTS Franca Koenig (Supervisor Prof. Dr. Ziemann) Natalya Korinetsko (Supervisor Prof. Dr. Dr. Tabatabai) Angela Armento (Supervisor Prof. Dr. Naumann) Martin Korn (Supervisor Prof. Dr. Dr. Tabatabai) Denis Canjuga (Supervisor Prof. Dr. Dr. Tabatabai) Felix Lennartz (Supervisor Prof. Dr. Dr. Tabatabai) Ghazal Darmani (Supervisor Prof. Dr. Ziemann) Chen Liang (Supervisor Prof. Dr. Ziemann) Debora Desideri (Supervisor Prof. Dr. Ziemann) Anne Lieb (Supervisor Prof. Dr. Ziemann) Bingshuo Li (Supervisors Prof. Dr. Schwarz, Prof. Dr. Zie- Adam Meder (Supervisor Prof. Dr. Ziemann) mann) Philipp Nakov (Supervisor PD Dr. Bischof) Srinath Rajaraman (Supervisor Prof. Dr. Dr. Tabatabai) Francesca Russo (Supervisor Prof. Dr. Ziemann) Sonja Schötterl (Supervisor Prof. Dr. Naumann) Martin Schippert (Supervisor Prof. Dr. Dr. Tabatabai) Yi Wang (Supervisors Prof. Dr. Ziemann, Dr. Sven Poli) Katrin Schulz (Supervisor PD Dr. Bischof) Charlotte Spencer (Supervisor Prof. Dr. Ziemann, Dr. Poli) Jakob Spogis (Supervisor Prof. Dr. Ziemann) MASTER STUDENTS Miriam Thies (Supervisor Prof. Dr. Ziemann) Natalia Tveriakhina (Supervisor PD Dr. Bischof) Ricarda Farsch (Supervisor Prof. Dr. Hertrich) Xueyu Yang (Supervisor Prof. Dr. Ziemann) Vanessa Frische (Supervisor Prof. Dr. Hertrich) Miriam Grunau (Supervisor Prof. Dr. Hertrich) Kerstin Jendrysik (Supervisor Prof. Dr. Hertrich) PROFESSORSHIP FOR NEUROREHABILITATION Anna-Lena Kast (Supervisor Prof. Dr. Hertrich) Stephanie Klein (Supervisor Prof. Dr. Dr. Tabatabai) Prof. Dr. Hermann Ackermann Alisa Selent (Supervisor Prof. Dr. Hertrich) Prof. Dr. Ingo Hertrich Rajka Sieger (Supervisor Prof. Dr. Dr. Tabatabai) 7 Department of Neurology and Stroke Clinical Studies MISTIE III: Minimally Invasive Surgery plus rt-PA for ICH Evacuation Phase III Investigator: Dr. Sven Poli S UTROKE ST DIES Precious: PREvention of Complications to Improve OUtcome A CTION II (EudraCT: 2015-004783-11): A multicenter, in elderly patients with acute Stroke. A randomised, open, double-blind, placebo-controlled, randomized, parallel- phase III, clinical trial with blinded outcome assessment group study to evaluate the safety and efficacy of Investigator: Dr. Sven Poli intravenous natalizumab (BG00002) on reducing infarct volume in acute ischemic stroke Prodast: Prospective Record Of the use of Dabigatran in Investigator: Dr. Sven Poli patients with Acute Stroke or TIA Investigator: Dr. Sven Poli ANNEXA-4: Prospective, open-label study of Andexanet alfa in patients receiving a factor XA-Inhibitor who have acute RASUNOA-Prime: Register für Akute Schlaganfälle Unter major bleeding Neuen Oralen Antikoagulantien - Prime Investigator: Dr. Sven Poli Investigator: Dr. Sven Poli ATTICUS: Apixaban for treatment of embolic stroke of RESPECT CVT: A clinical trial comparing efficacy and safety undetermined source of dabigatran etexilate with warfarin in patients with cere- Investigator: Dr. Sven Poli bral venous and dural sinus Investigator: Dr. Sven Poli CAPIAS: The carotid plaque imaging in acute stroke (CAPIAS) study: protocol and initial baseline data RESPECT ESUS: Randomized, double-blind Evaluation in Investigator: Prof. Dr. Ulf Ziemann secondary Stroke Prevention comparing the Efficacy and safety of the oral Thrombin inhibitor dabigatran etexilate CL1-44819-004: Randomized Efficacy and Safety Trial with (110 mg or 150 mg, oral b.i.d.) versus acetylsalicylic acid Oral S 44819 after Recent Ischemic Cerebral Event (100 mg oral q.d.) in patients with Embolic Stroke of Investigator: Prof. Dr. Ulf Ziemann Undetermined Source Investigator: Dr. Sven Poli DS1040_A_U103: Safety, Pharmacokinetics and pharma- codynamics of DS1040B in Subjects with Acute Ischemic REVACEPT (EudraCT-Nr.: 2011-001006-10): An inhibitor of Stroke platelet adhesion in symptomatic carotid stenosis: A phase Investigator: Dr. Sven Poli II, multicenter, randomized, dose-finding,
Load more

Recommended publications
  • Little Proteins, Big Clues After a Quarter of a Century, the Amyloid Hypothesis for Alzheimer’S Disease Is Reconnecting to Its Roots in Prion Research
    ALZHEIMER’S DISEASE OUTLOOK SIMON FRASER/JAMES KING-HOLMES/SCIENCE PHOTO LIBRARY PHOTO KING-HOLMES/SCIENCE SIMON FRASER/JAMES At autopsy, the brains of Alzheimer’s patients (right) are filled with amyloid plaques, reminiscent of the plaques seen in the brains of animals with scrapie (left). AMYLOID Little proteins, big clues After a quarter of a century, the amyloid hypothesis for Alzheimer’s disease is reconnecting to its roots in prion research. BY JIM SCHNABEL It is easy to forget how recently Alzheimer’s resembling those seen in scrapie, often sur- disease entered the public consciousness. rounded by dying neurons and their twisted n September 1984, a group of prominent For many decades after it first appeared in the axons and dendrites. When doused with Congo researchers from around the world met in medical literature, the term referred only to red, a standard pathology stain, and illumi- Scotland to discuss a disease that afflicted an obscure, early onset form of dementia. nated with polarized light, the Alzheimer’s Isheep and goats. What we now know as common, late-onset plaques — just like scrapie plaques — displayed Scrapie, as they called it, was important Alzheimer’s was then called ‘senile dementia’ — an apple-green shimmer, a prismatic sign of the for more than agricultural reasons — it was and it was so prevalent among the elderly that hydrogen bonds that held their fibrils tightly also the most easily studied example of an it hardly seemed worth classifying as a disease together. Protein aggregates that had this emerging class of diseases that destroyed (see ‘A problem for our age’, page S2).
    [Show full text]
  • CSF Protein Dynamics in Murine Models of A-Synucleinopathy and Cerebral B-Amyloidosis
    CSF protein dynamics in murine models of a-synucleinopathy and cerebral b-amyloidosis Dissertation zur Erlangung des Grades eines Doktors der Naturwissenschaften der Mathematisch-Naturwissenschaftlichen Fakultät und der Medizinischen Fakultät der Eberhard-Karls-Universität Tübingen vorgelegt von Timo Eninger aus Bad Saulgau, Deutschland November 2017 Tag der mündlichen Prüfung: 13.11.2017 Dekan der Math.-Nat. Fakultät: Prof. Dr. W. Rosenstiel Dekan der Medizinischen Fakultät: Prof. Dr. I. B. Autenrieth 1. Berichterstatter: Prof. Dr. M. Jucker 2. Berichterstatter: Prof. Dr. B. Maček Prüfungskommission: Prof. Dr. M. Jucker Prof. Dr. B. Maček Dr. D. David Prof. Dr. P. Heutink Erklärung Ich erkläre hiermit, dass ich die zur Promotion eingereichte Arbeit mit dem Titel: “CSF protein dynamics in murine models of a-synucleinopathy and cerebral b-amyloidosis” selbstständig verfasst, nur die angegebenen Quellen und Hilfsmittel benutzt und wörtlich oder inhaltlich übernommene Stellen als solche gekennzeichnet habe. Ich versichere an Eides statt, dass diese Angaben wahr sind und dass ich nichts verschwiegen habe. Mir ist bekannt, dass die falsche Abgabe einer Versicherung an Eides statt mit Freiheitsstrafe bis zu drei Jahren oder einer Geldstrafe bestraft wird. Tübingen, den 18. Juli 2017 Unterschrift Für Elisabeth, meine Eltern und Elena “No great mind has ever existed without a touch of madness.” - Aristotele Summary Parkinson’s (PD) and Alzheimer’s disease (AD) are the two most common neurodegen- erative diseases and of growing importance for the rapidly aging population of indus- trialized countries. A common feature of both diseases is the progressive accumulation of proteins in insoluble aggregates, which are considered to play a fundamental role in the pathogeneses ultimately resulting in marked neuronal loss.
    [Show full text]
  • Dr. Melanie Meyer-Luehmann Curriculum Vitae
    Dr. Melanie Meyer-Luehmann Curriculum Vitae Date of Birth: May 11, 1974 in Lahr, Germany Married, 1 daughter (Date of birth March 31, 2007) Academic Education: • 1993-1999: Undergraduate and graduate studies of Biology at the University of Freiburg, Germany • 1999-2000: M.S. (Diplom) Thesis at the University of Michigan, Ann Arbor, USA with Prof. John Wayne Aldridge. Title: Extracellular recordings in the substantia nigra pars reticulate during normal grooming behavior in rats. • 2000: M.S. (Diplom) in Biology, grade: very good, University of Freiburg, Germany • 2000-2004: PhD Thesis at the University of Basel, Switzerland with Prof. Mathias Jucker. Title: Experimental approaches to study cerebral amyloidosis in a transgenic mouse model of Alzheimer`s disease. • 2004: PhD in Neurobiology, grade: summa cum laude, University of Basel, Switzerland Postdoctoral Training: • 2004: Postdoctoral fellow at the Hertie Institute of Clinical Brain Research, Tuebingen, Germany, with Prof. Mathias Jucker • 2005-2008: Postdoctoral fellow at the Massachusetts General Institute for Neurodegenerative Disease (MIND), Harvard Medical School, Boston, USA, with Prof. Bradley T. Hyman Advanced Professional Degrees: • Since October 2008: Independent group leader at the Adolf-Butenandt-Institut, Ludwig-Maximilians-University Munich, Germany Awards and Honours: • Emmy Noether Career Development Grant from the Deutsche Forschungsgemeinschaft DFG (since July 2009) • Member of the "SFB 596 Molecular Mechanisms of Neurodegeneration" (since August 2009) Publications: 1. Koffee, R.M., Meyer-Luehmann, M., Hashimoto, T., Adams, K.W., Mielke, M.L., Garcia-Alloza, M., Micheva, K.D., Smith, S.J., Kim, M.L., Lee, V.M., Hyman, B.T., Spires-Jones, T.L. (2009). Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques.
    [Show full text]
  • EXTRA VIEWS Ab Seeds and Prions
    Prion, 11:215–225, 2017 Published with license by Taylor & Francis ISSN: 1933-68961933-690X online DOI: 10.1080/19336896.2017.1334029 EXTRA VIEWS Ab seeds and prions: How close the fit? Jay Rasmussena,b,c, Mathias Juckera,b, and Lary C. Walkerd aDepartment of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen,€ Tubingen,€ Germany; bGerman Center for Neurodegenerative Diseases (DZNE), Tubingen,€ Germany; cGraduate Training Center of Neuroscience, University of Tubingen,€ Tubingen,€ Germany; dDepartment of Neurology and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA ABSTRACT. The prion paradigm is increasingly invoked to explain the molecular pathogenesis of neurodegenerative diseases involving the misfolding and aggregation of proteins other than the prion protein (PrP). Extensive evidence from in vitro and in vivo studies indicates that misfolded and aggregated Ab peptide, which is the probable molecular trigger for Alzheimer’s disease, manifests all of the key characteristics of canonical mammalian prions. These features include a b-sheet rich architecture, tendency to polymerize into amyloid, templated corruption of like protein molecules, ability to form structurally and functionally variant strains, systematic spread by neuronal transport, and resistance to inactivation by heat and formaldehyde. In addition to Ab, a growing body of research supports the view that the prion-like molecular transformation of specific proteins drives the onset and course of a remarkable variety
    [Show full text]
  • In Focus Neurology.Org/N
    Volume 92, Number 17, April 23, 2019 In Focus Neurology.org/N Robert A. Gross, MD, PhD, FAAN, Editor-in-Chief, Neurology® Notable in Neurology this week This issue features an article that investigates false outcome prediction of the Status Epilepticus Severity Score, specifically the corresponding clinical characteristics; another determines the effectiveness of a quantitative speech measure to identify and monitor motor speech impairment in patients with primary progressive aphasia. A featured Contemporary Issues article examines the current state of knowledge in new-onset refractory status epilepticus and proposes an outline for future research. Articles MORE ONLINE Cognitive phenotypes in temporal lobe epilepsy are associated with Editor's Summary Audio summary of distinct patterns of white matter network abnormalities highlighted articles. Cognitive impairment in patients with temporal lobe NPub.org/edsum epilepsy (TLE) is highly heterogeneous, ranging from no impairment to globally impaired cognition. The authors identify distinct cognitive phenotypes within TLE and reveal network abnormalities associated with each phenotype. Such phenotyping could enable the ability to match patients to treatments, improving cognitive outcomes. Page 791 Racial differences in intervention rates in individuals with ALS: A case-control study This study confirms longer survival in African American patients with amyotrophic lateral sclerosis (ALS) compared to white patients and suggests this difference may be secondary to higher rates of tracheostomy in African American patients. There may be racial differences in patients’ choices regarding supportive care for ALS, which should be considered when working with patients. Page 792 From editorialists Armon & Albert: “In considering the role of ethnicity in end-of-life decisions, great sensitivity is needed, in order not to imply that there is something wrong with opting for [tracheostomy with invasive ventilation].
    [Show full text]
  • Modeling the Prion Aspect of Cerebral Β-‐Amyloidosis in Organotypic Slice
    Modeling the prion aspect of cerebral β-amyloidosis in organotypic slice cultures and mice Dissertation zur Erlangung des Grades eines Doktors der Naturwissenschaften der Mathematisch-Naturwissenschaftlichen Fakultät und der Medizinischen Fakultät der Eberhard-Karls-Universität Tübingen vorgelegt von Renata Michaela Werner geb. Novotný aus Freiburg im Breisgau, Deutschland März 2016 Tag der mündlichen Prüfung: 14.07.2016 Dekan der Math.-Nat. Fakultät: Prof. Dr. W. Rosenstiel Dekan der Medizinischen Fakultät: Prof. Dr. I. B. Autenrieth 1. Berichterstatter: Prof. Dr. M. Jucker 2. Berichterstatter: Prof. Dr. B. Heimrich Prüfungskommission: Prof. Dr. M. Jucker Prof. Dr. B. Heimrich Prof. Dr. O. Riess Prof. Dr. S. Di Giovanni 2 Erklärung Ich erkläre, dass ich die zur Promotion eingereichte Arbeit mit dem Titel: “Modeling the prion aspect of cerebral β-amyloidosis in organotypic slice cultures and mice” selbständig verfasst, nur die angegebenen Quellen und Hilfsmittel benutzt und wörtlich oder inhaltlich übernommene Stellen als solche gekennzeichnet habe. Ich versichere an Eides statt, dass diese Angaben wahr sind und dass ich nichts verschwiegen habe. Mir ist bekannt, dass die falsche Angabe einer Versicherung des Eides statt mit Freiheitsstrafe bis zu drei Jahren oder mit Geldstrafe bestraft wird. Tübingen, 16.03.2016 …….………….. Unterschrift 3 For my family 4 Acknowledgements First and foremost I would like to express my special appreciation and gratitude to Prof. Mathias Jucker for giving me the opportunity to pursue my PhD in his department at the Hertie Institute for Clinical Brain Research in Tübingen. I would like to thank him for his supervision as well as his support and advice during my PhD work.
    [Show full text]
  • Aβ Seeds and Prions: How Close the Fit? Jay Rasmussen, University of Tübingen Mathias Jucker, University of Tübingen Lary Walker, Emory University
    Aβ seeds and prions: How close the fit? Jay Rasmussen, University of Tübingen Mathias Jucker, University of Tübingen Lary Walker, Emory University Journal Title: Prion Volume: Volume 11, Number 4 Publisher: Taylor & Francis | 2017-07-04, Pages 215-225 Type of Work: Article | Final Publisher PDF Publisher DOI: 10.1080/19336896.2017.1334029 Permanent URL: https://pid.emory.edu/ark:/25593/s4q1c Final published version: http://dx.doi.org/10.1080/19336896.2017.1334029 Copyright information: Copyright © 2017 The Author(s). Published with license by Taylor & Francis This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/). Accessed September 28, 2021 10:33 PM EDT Prion ISSN: 1933-6896 (Print) 1933-690X (Online) Journal homepage: http://www.tandfonline.com/loi/kprn20 Aβ seeds and prions: How close the fit? Jay Rasmussen, Mathias Jucker & Lary C. Walker To cite this article: Jay Rasmussen, Mathias Jucker & Lary C. Walker (2017) Aβ seeds and prions: How close the fit?, Prion, 11:4, 215-225, DOI: 10.1080/19336896.2017.1334029 To link to this article: http://dx.doi.org/10.1080/19336896.2017.1334029 © 2017 The Author(s). Published with license by Taylor & Francis© Jay Rasmussen, Mathias Jucker, and Lary C. Walker Accepted author version posted online: 28 Jun 2017. Published online: 28 Jun 2017. Submit your article to this journal Article views: 398 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=kprn20 Download by: [Emory University] Date: 14 September 2017, At: 10:45 Prion, 11:215–225, 2017 Published with license by Taylor & Francis ISSN: 1933-68961933-690X online DOI: 10.1080/19336896.2017.1334029 EXTRA VIEWS Ab seeds and prions: How close the fit? Jay Rasmussena,b,c, Mathias Juckera,b, and Lary C.
    [Show full text]
  • Endogenous Murine AΒ Increases Amyloid Deposition In
    Neurobiology of Aging 36 (2015) 2241e2247 Contents lists available at ScienceDirect Neurobiology of Aging journal homepage: www.elsevier.com/locate/neuaging Endogenous murine Ab increases amyloid deposition in APP23 but not in APPPS1 transgenic mice Jasmin Mahler a,b,c, Jose Morales-Corraliza d,e, Julia Stolz a,b,c, Angelos Skodras a,b, Rebecca Radde a, Carmen C. Duma a, Yvonne S. Eisele a,b, Matthew J. Mazzella d, Harrison Wong d, William E. Klunk e,f,g, K. Peter R. Nilsson h, Matthias Staufenbiel a,b, * Paul M. Mathews d,e, Mathias Jucker a,b, , Bettina M. Wegenast-Braun a,b,* a Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany b DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany c Graduate School for Cellular and Molecular Neuroscience, University of Tübingen, Tübingen, Germany d Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA e Department of Psychiatry, New York University School of Medicine, New York, NY, USA f Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA g Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA h Department of Chemistry, IFM, Linköping University, Linköping, Sweden article info abstract Article history: Endogenous murine amyloid-b peptide (Ab) is expressed in most Ab precursor protein (APP) transgenic Received 18 December 2014 mouse models of Alzheimer’s disease but its contribution to b-amyloidosis remains unclear. We Received in revised form 12 March 2015 demonstrate w35% increased cerebral Ab load in APP23 transgenic mice compared with age-matched Accepted 18 March 2015 APP23 mice on an App-null background.
    [Show full text]
  • Corruptive Templating of Aβ in Alzheimer's Disease
    Corruptive Templating of Aβ In Alzheimer’s Disease Lary Walker Yerkes National Primate Research Center and Department of Neurology, Emory University Many thanks to Rebecca Rosen, Jeromy Dooyema, Amarallys Cintron, Jason Fritz, James Lah, Ranjita Betarbet, Harry LeVine III, Yvonne Eisele and Mathias Jucker Funding: PO1AG026423, P50AG025688, R21AG40589, CART Foundation ADC Directors Meeting April 21, 2012 Overview 1) The spectrum of proteopathies 2) Cerebral Aβ amyloidosis is inducible in APP-transgenic mice by Aβ-rich brain extracts 3) Aggregated Aβ itself is the seed 4) Aβ seeds travel within, and to, the brain 5) Aβ seeds vary in size 6) Implications, caveats and open questions The spectrum of proteopathies • Alzheimer’s disease (Aβ and tau) • Prion diseases (PrP) • Tauopathies (tau) • Huntington’s disease/triplet repeat disorders (polyQ) • Parkinson’s disease/Lewy body disease (α-synuclein) • Cerebral amyloid angiopathies (Aβ, cystatin, etc.) • Amyotrophic lateral sclerosis (SOD, TDP43, FUS) • FTLD ubi+, tau- (TDP43, FUS) • Familial British Dementia (ABri) • Familial Danish Dementia (ADan) • Familial Encephalopathy w/ Neuroserpin Inclusion Bodies (neuroserpin) • Systemic amyloidoses (AA, AL, Transthyretin, etc) • Type II diabetes (amylin) • Cirrhosis with hepatocytic inclusions (α1-antitrypsin) • … Disease or disease class Aggregating protein(s) Alzheimer's disease Amyloid β peptide (Aβ); Tau protein (see tauopathies) Cerebral β-amyloid angiopathy Amyloid β peptide (Aβ) Retinal ganglion cell degeneration in glaucoma Amyloid β peptide
    [Show full text]
  • Monkey, Mouse Or Zebrafish? Ethical and Scientific Considerations in Choosing Model Organisms for Animal Experiments
    Monkey, Mouse or Zebrafish? Ethical and Scientific Considerations in Choosing Model Organisms for Animal Experiments 1 July 2021, 13.15 – 18.00 Online – Join by Zoom Organized by the Ethics Committee for Animal Experimentation (ECAE) of the Swiss Academies of Arts and Sciences Over 80% of animals used in research are mice and rats. How do researchers justify the choice of animals for their research? Does the chosen species always provide the greatest epistemic benefit – or the least harm for that benefit? Researchers may also choose animals that they are familiar with, that are commonly used by their peers, or that cost the least. Furthermore, the Swiss Animal Welfare Act stipulates that “experiments on animals higher on the evolutionary scale may only be carried out if the purpose of the experiment cannot be achieved in animal species that are lower on the evolutionary scale”. From this an implicit moral hierarchy has emerged with primates at the top, followed by dogs and cats, other larger mammals, rodents, and – at the bottom – fish. Although this hierarchy is biased by subjective human preferences (related- ness, familiarity, attractiveness) rather than based on biological evidence, researchers may shy away from using animals 'higher on the evolutionary scale' out of moral concerns, higher bureaucratic burden or fear of harassment by militant activists. The aim of this symposium is to identify scientific and ethical problems in the choice of model organ- isms for animal experiments and raise awareness among scientists and regulators for these problems, using research on Alzheimer’s Disease as a case study. The symposium should help researchers and regulators in asking the right questions when choosing and evaluating model organisms.
    [Show full text]
  • 2005 Program
    PROGRAM EIGHTY FIRST ANNUAL MEETING OF THE AMERICAN ASSOCIATION OF NEUROPATHOLOGISTS JUNE 9-12, 2005 HYATT REGENCY CRYSTAL CITY HOTEL ARLINGTON, VIRGINIA CONTENTS Page AANP Organization Officers and Committees 1-3 General Information Hotel and Registration 4 Author/ Presenter Information 5-7 PowerPoint Presenters 5-6 Poster Presenters 6 Speaker Ready Room 7 Microscope Room 7 Business Meeting 7 Special Meetings 7 Published Abstracts 8 CME Information 8 Disclosures 8 Annual Reception 9 Meeting Sponsors and Donors 9 Hotel Floor Plan 10 Program and Scientific Sessions 11-37 MEETING AT A GLANCE 12-13 Special Course 14 Presidential Symposium 15 Scientific Sessions Platform Presentations Friday Morning (Abstracts 1-28) 16-19 Friday Afternoon (Abstracts 29-44) 20-21 Saturday Morning (Abstracts 139-153) 31-33 Saturday Afternoon (Abstracts 154-173) 34-37 Poster Presentations (Abstracts 45-138) 22-30 Author Index 38-43 1 AMERICAN ASSOCIATION OF NEUROPATHOLOGISTS Office of Secretary-Treasurer George Perry Institute of Pathology Case Western Reserve University 2095 Adelbert Rd Cleveland, OH 44106 Phone: 216-368-2488 Fax: 216-368-8964 Email: [email protected] Home page http://www.neuropath.org OFFICERS Harry V. Vinters, President Leroy R. Sharer, Vice-President Bette K. DeMasters, President Elect Mark L. Cohen, Vice-President Elect Barbara J. Crain, Vice-President for Professional Affairs George Perry, Secretary-Treasurer Kevin A. Roth, Assistant Secretary-Treasurer OTHER EXECUTIVE COUNCIL MEMBERS Dennis W. Dickson (Past President) Jeffrey A. Golden (Member-at-Large) Michael N. Hart (JNEN) Roger E. McLendon (Member-at-Large) Joseph E. Parisi (Past President) Clayton A. Wiley (Past President) ARCHIVIST Richard L.
    [Show full text]
  • Conference Report: Dementia Research and Care and Its Impact in Switzerland
    Special article | Published 23 November 2020 | doi:10.4414/smw.2020.20376 Cite this as: Swiss Med Wkly. 2020;150:w20376 Conference report: dementia research and care and its impact in Switzerland Leyhe Thomasa, Jucker Mathiasb, Nef Tobiasc, Sollberger Marcd, Riese Floriane, Haba-Rubio Joséf, Verloo Henkg, Lüthi Regulah, Becker Stefaniei, Popp Juliusj a University of Basel, Geriatric Psychiatry, University Department of Geriatric Medicine Felix Platter, and Centre of Old Age Psychiatry, Psychiatric University Hospital, Basel, Switzerland b Hertie Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany c ARTORG Centre for Biomedical Engineering Research, University of Bern, Switzerland d Memory Clinic, Geriatric Psychiatry, University Department of Geriatric Medicine Felix Platter, and Department of Neurology, University Hospital Basel, Switzerland e University Hospital of Psychiatry Zurich, Department of Geriatric Psychiatry, Zurich, Switzerland f Centre du Sommeil de Florimont and Centre for Investigation and Research on Sleep/CHUV, Lausanne, Switzerland g Service of Old Age Psychiatry, Lausanne University Hospital, Switzerland, and School of Health Sciences, Switzerland h Psychiatric University Hospital, Basel, Switzerland i Alzheimer Switzerland, Bern, Switzerland j Old Age Psychiatry, Department of Psychiatry, University Hospital of Lausanne, and University of Zürich, Department of Geriatric Psychiatry, University Hos- pital of Zürich, Switzerland Summary tibody against β-amyloid. Other approaches also show promise. In China, sodium oligomannate has been ap- In October 2019, a Swiss panel of experts met for the De- proved to treat Alzheimer's disease. The substance sup- mentia Summit in Brunnen, Switzerland, to discuss the lat- presses gut bacterial amino acids-shaped neuroinflamma- est scientific findings on basic and clinical research, as tion to inhibit Alzheimer’s disease progression.
    [Show full text]