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Cphi Annual Industry Report 2019

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Cphi Annual Industry Report 2019 New modalities, new methods and new thinking to solve old problems Industry Expert Panel Submissions CPhI Annual Industry Report 2019 Released at CPhI Worldwide, 5 - 7 November, 2019 Frankfurt, Germany www.cphi.com The CPhI Annual Report is a comprehensive and critically important publication that analyses key trends and innovations forecast by our panel of world class experts. Running as a series of opinions and articles, the CPhI experts call upon their considerable commercial and technical acumen to prophesize the future direction, technologies, opportunities and threats in pharma. It’s an essential read for executives who wish to get a head start today on the shape of tomorrow’s industry. Contents CPhI’s Pharma Industry Rankings: Evaluation of current Pharma ...................................................................................... 3 Part 1. Innovation, AI and Regulation Building Quality into Pharma Manufacturing, from Molecule to Medicine: Pharma 4.0 .........................................12 BIKASH CHATTERJEE, PRESIDENT AND CHIEF SCIENCE OFFICER, PHARMATECH ASSOCIATES Chaos to Continual Improvement: Path to Harmonization ................................................................................................20 AJAZ HUSSEIN PHD, THE NATIONAL INSTITUTE FOR PHARMACEUTICAL TECHNOLOGY & EDUCATION, INC., USA Pharmaceutical Quality: Concepts, Misconceptions, Realities And Remedies ............................................................31 GIRISH MALHOTRA PRESIDENT AT EPCOT INTERNATIONAL Part 2. Biologics (Capacity and Biosimilars) Mammalian Biomanufacturing Industry Overview ...............................................................................................................40 DAWN M. ECKER, DIRECTOR OF BIOTRAK DATABASE SERVICES, BIOPROCESS TECHNOLOGY GROUP, BDO -USA, LLP PATRICIA SEYMOUR, MANAGING DIRECTOR, BIOPROCESS TECHNOLOGY GROUP, BDO -USA, LLP Biopharmaceutical Therapies And Biosimilars: Not Your Father’s Medication ............................................................46 EMIL W. CIURCZAK, DORAMAXX CONSULTING Part 3. Biologics (Advanced Therapies and China) Trends in Chinese Biopharmaceutical Manufacturing, Contract Manufacturing .......................................................52 VICKY QING XIA,, BIOPLAN ASSOCIATES, INC. ROCKVILLE, MD New Developments in Bioprocessing Development & Manufacturing .........................................................................56 MICHIEL E. ULTEE, PHD, ULTEEMIT BIOCONSULTING, LLC Part 4. Contract Services, new Modalities and Breakthroughs Increase in Drug Approvals and Priority Review Shows the Future Is Bright for the CMO Industry ....................61 ADAM BRADBURY INDUSTRY ANALYST, PHARMSOURCE, A GLOBALDATA PRODUCT Patient Centricity: The New Nexus For CDMOs .......................................................................................................................65 STUART E. NEEDLEMAN, CHIEF COMMERCIAL OFFICER, PIRAMAL PHARMA SOLUTIONS Newer drugs will require a new way of manufacturing centered on the patient ......................................................70 PETER SOELKNER, MANAGING DIRECTOR VETTER PHARMA INTERNATIONAL GMBH CPhI Annual Industry Report 2019: Expert Contribution 2 CPhI Worldwide, November 2019, Frankfurt | Produced by Defacto CPhI’s Pharma Industry Rankings: Evaluation of current Pharma This year’s CPhI Pharma Industry Rankings report once ‘Competitiveness’, and ‘Finished Product’ – all which are again returns, bringing a key analysis of the strength of taken into consideration for their final overall scores. the major pharmaceutical markets and the industry as a whole. The report comes just in time for CPhI Worldwide 2019 taking place November (5-7) in Frankfurt, Germany. CPhI The survey has been completed by 350 top pharma Worldwide 2019 is expecting over 45,000 visitors from experts giving the best picture possible of global more than 160 countries, making it the largest pharma performance in 2019. Country’s pharmaceutical markets exhibition ever. The event promises unbeatable insights on are assessed on a range of key indicators, such as market pharma’s latest trends, with forecasts on potential future ‘growth potential’, ‘API manufacturing’, ‘Innovation’, implications, as well as unrivaled networking opportunities. The overall index: what do the collated findings mean for the global industry in 2020? When collated across all markets, and all survey categories, the Perhaps more significantly, overall growth is perceived to be industry as a whole has experienced a 2.48% increase, which rising by an impressive 5.4% annually, which bodes extremely indicates the market has increased its overall confidence. well for CPhI Worldwide attendees in the year ahead. Pharma market growth potential This year’s report sees China (7.66) surge to the top Germany (6.92) – the host of this year’s CPhI Worldwide – of the rankings for growth potential overtaking both retains its place as Europe’s leading market for growth potential. India (7.43) and USA (6.92). China also displayed It has, significantly, also overtaken the USA, boasting an the biggest growth in percentage terms, increasing impressive 11.4% increase in 2018, and becoming the leading 12.5% from last year. This likely reflects the real effort Western economy for growth. Such exceptional growth to increase standards throughout the supply chain, coincides with the UK’s declining fortunes in growth potential which have been recognised by executives, generating terms, as industry experts envisage (whether based on reality an increasingly prominent international business or perception) Germany being the leading beneficiary of the reputation. UK’s exit from the European union. Growth Potential of Pharma Industry 2019 Ita ly UK Spa in France Jap an Kor ea USA Germ an y India China 0 1 2 3 4 5 6 7 8 9 10 Growth Potential Score CPhI Annual Industry Report 2019: Expert Contribution 3 CPhI Worldwide, November 2019, Frankfurt | Produced by Defacto API manufacturing API manufacturing quality is always a key indicator for the Italy (6.7). Korea’s performance sees the country improve its performance of pharmaceutical markets – with many of perceived quality of manufactured APIs, which could be a pharma’s developed markets still perceived as ahead of the positive response from the market of recent government large volume producers. With a respectable growth of 2.5%, efforts to repatriate manufacturing and the desire for Japan (7.97) has pushed ahead of Germany (7.85) to the generic companies to source locally manufactured APIs. number one spot for API manufacturing quality. But, it is In Europe, Germany (7.85) retains its position as the Spain (7.16) and Korea (6.89) that are the big movers, with preeminent API Manufacturer (7.78) ahead of France (7.31) scores increasing by 6.4% and 5.5% respectively overtaking and the United Kingdom (7.30). API Manufacturing 2019 China India Ita ly Kor ea Spa in UK France USA Germ an y Jap an 0 1 2 3 4 5 6 7 8 9 10 API Manufacturing Score Innovation The USA (8.12) retains its top position in this year’s report. Korea as the up and coming region for innovation It also boasts the largest growth increase (2.5%) out of all (experiencing an 8% rise over the last two years). India, assessed markets, while Japan (7.51) and Germany (7.43) surprisingly, has fallen to the bottom of the table with the remain in second and third position respectively. 2019 has worst growth rate (-6.3%) of all the countries. However, seen Korea take huge strides forward in innovation, scoring according to a recent report , the Indian Pharmaceutical a reputable 6.54 and overtaking Spain (6.13) and India Alliance (IPA) is urging the government to set up a fund to (6.01). Korea’s reputation continues reaping the rewards of provide a ‘much-needed boost to innovation in the pharma recent regulatory reforms and a growing biotech market, and biopharma space’. If enacted, this may see an improved with an increasing number of companies highlighting reputation for innovation in the next few years. Innovativness of The Pharma Industry 2019 India China Spa in Ita ly Kor ea France UK Germ an y Jap an USA 0 1 2 3 4 5 6 7 8 9 Innovativeness Score CPhI Annual Industry Report 2019: Expert Contribution 4 CPhI Worldwide, November 2019, Frankfurt | Produced by Defacto Competitiveness As with innovation, the USA (7.04) takes the top spot for competitive across more sectors than ingredients. At the Competitiveness. Surprisingly, given its strong showing in opposite end of the table, Italy falls to last position, with other categories, Germany (6.47) has slipped from second a score of 5.25. The UK also slides down the rankings to fourth, with a decrease of 1.3%. Moving up to third is scoring 5.77, down 2.8% on last year’s score of 5.94. China (6.56) with the largest increase in growth (3.9%) for Competitiveness was assessed through respondents competitiveness. This may stem from executives belief that evaluation of each country’s tax environment, quality of the Chinese government is actively increasing standards employees, infrastructure, research potential, labor costs, throughout its pharma sector and becoming increasingly accessibility, and access to funds. Overall Competitiveness 2019 Ita ly Spa in UK France Kor ea Jap an Germ an y China India USA 0 1 2 3 4 5 6 7 8 9 10 Overall Competitiveness Score Finished product manufacturing Germany (8.17), the U.S. (8.11) and Japan (7.97) are again UK’s pharma industry with Germany perceived as the ranked, as tier one nations, above
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