www.impactjournals.com/oncotarget/ Oncotarget, 2017, Vol. 8, (No. 39), pp: 66656-66667 Review The role of toll-like receptor 4 in tumor microenvironment Jing Li1,2,3,4,5, Fan Yang2,3,4,5,6, Feng Wei1,3,4,5,6 and Xiubao Ren1,2,3,4,5,6 1Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China 2Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China 3National Clinical Research Center for Cancer, Tianjin, China 4Key Laboratory of Cancer Prevention and Therapy, Tianjin, China 5Tianjin’s Clinical Research Center for Cancer, Tianjin, China 6Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China Correspondence to: Xiubao Ren, email:
[email protected],
[email protected] Keywords: TLR4, immune cells, tumor cells, tumor microenvironment Received: November 24, 2016 Accepted: June 27, 2017 Published: July 08, 2017 Copyright: Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Tumors are closely related to chronic inflammation, during which there are various changes in inflammatory sites, such as immune cells infiltration, pro- inflammation cytokines production, and interaction between immune cells and tissue cells. Besides, substances, released from both tissue cells attacked by exogenous etiologies, also act on local cells. These changes induce a dynamic and complex microenvironment favorable for tumor growth, invasion, and metastasis. The toll-like receptor 4 (TLR4) is the first identified member of the toll-like receptor family that can recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular pattern (DAMPs).