Eplivanserin | Medchemexpress

Total Page：16

File Type：pdf, Size：1020Kb

Inhibitors Product Data Sheet Eplivanserin • Agonists Cat. No.: HY-10792 CAS No.: 130579-75-8 Molecular Formula: C₁₉H₂₁FN₂O₂ • Molecular Weight: 328.38 Screening Libraries Target: 5-HT Receptor Pathway: GPCR/G Protein; Neuronal Signaling Storage: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY Description Eplivanserin (SR-46349) is a potent, selective and orally active 5-HT2A receptor antagonist, with an IC50 of 5.8 nM in rat cortical membrane, and a Kd of 1.14 nM. Eplivanserin displays >20-fold selectivity more selective for 5-HT2A than 5-HT2B and [1][2] 5-HT2C . IC₅₀ & Target 5-HT2A Receptor 5-HT2A Receptor 5-HT2C Receptor 5.8 nM (IC50, in rat cortical 1.14 nM (Ki) 120 nM (IC50) membrane) In Vitro Eplivanserin hemifumarate (SR 46349B) shows weak inhibition on other 5-HT kinases, with IC50s of 0.12 μM (Pig cortex 5-HT 1C), 14 μM (Rat hippocampus 5-HT1A), and 16 μM (Rat stnatum 5-HT1B, Ox caudate nucleus 5-HT1D). Eplivanserin also has + inhibitory effects on rat cortex adrenergic α1 and α2, rat whole brain histammine H1, Na channel, and rat striatum [1] dopamine D1 and D2, with IC50s of 3.4 μM, 1.0 μM, 5.0 μM, 39 μM, 9 μM and 28 μM, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. 3 In Vivo Eplivanserin hemifumarate (SR 46349B) inhibits 5-HT2 receptor binding of [ H]ketanserin with an ED50 of 0.087 mg/kg after i.p. injection, and 0.097 mg/kg after p.o administration in mice[1]. SR 46349B (0.25-1 mg/kg; i.p.) blocks Cocaine-evoked hyperactivity following repeated Cocaine treatment in rats[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. REFERENCES [1]. Rinaldi-Carmona M, et al. Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist. J Pharmacol Exp Ther. 1992 Aug;262(2):759-68. [2]. Malgorzata Filip, et al. Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses. J Pharmacol Exp Ther. 2004 Sep;310(3):1246-54. McePdfHeight Page 1 of 2 www.MedChemExpress.com Caution: Product has not been fully validated for medical applications. For research use only. Tel: 609-228-6898 Fax: 609-228-5909 E-mail: [email protected] Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA Page 2 of 2 www.MedChemExpress.com.

Copy Link

Recommended publications

By ANDREA PETERSEN Getty Images for Those Who Have Trouble
By ANDREA PETERSEN Getty Images For those who have trouble sleeping, there may soon be new ways to summon the sandman. Several pharmaceutical companies are working on new approaches to treat insomnia. The compounds are meant to work differently than current leading sleep aids such as Ambien and Lunesta, which, while generally safe, can have troubling side effects because they act on many areas of the brain. By contrast, many of the drugs being developed target particular systems responsible for sleep and wakefulness. The hope is that they will have fewer side effects and less potential for addiction and cognition problems the next day. New drugs are in the works to treat insomnia, which affects 10% to 30% of Americans (and more women than men). Andrea Peterson explains. About 30% of American adults have insomnia symptoms each year, scientific studies estimate. Some 10% of the population has chronic insomnia, which is generally defined as having difficulty sleeping at least three times a week for a month or more. Chronic insomnia sufferers also feel tired, cranky or foggy-headed during the day. Insomnia comes in various forms. Some people have a tough time falling asleep and others wake in the middle of the night and have trouble getting back to sleep. Some people rise for the day too early. Insomnia can increase the risk for other conditions, including heart disease, diabetes and depression. Merck & Co. is investigating a compound that inhibits the action of orexin receptors, which in turn interferes with the activity of orexin, a chemical in the brain that produces alertness.
[Show full text]
204569Orig1s000
CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 204569Orig1s000 MEDICAL REVIEW(S) Cross Discipline Team Leader Review 3. CMC/Device Dr. Khairuzzaman found the drug product portion of the NDA to be acceptable, and without need for phase 4 commitments. Dr. Sapru’s review stated that with the exception of a pending issue concerning the control of potential genotoxic impurity (b) (4) the NDA was approvable in terms of drug substance. Dr. Suarez found that the NDA was acceptable from a biopharmaceutics perspective. The Office of Compliance issuance of an acceptable recommendation for drug substance manufacturing and testing facilities was pending at the time of this review. 4. Nonclinical Pharmacology/Toxicology Dr. Richard Siarey completed the primary nonclinical review, and Dr. Lois Freed completed a supervisory memo. Dr. Siarey’s overall conclusion was that from a nonclinical perspective, approval of the suvorexant NDA was recommended. However, he found evidence that catapelxy was observed in dogs exposed to MK-4305 (suvorexant) near Tmax, although he concluded that additional information could have been gained by studying the drug in an experimental model that has been used for diagnosing cataplexy in dogs. Dr. Siarey suggested that since cataplexy occurred in dogs near Tmax, a time at which if used for insomnia patients would ordinarily be in bed, safety concern for humans was reduced. Dr. Siarey also found that the neurobehavioral assessment in the pre- and post-natal developmental study was not complete, as the passive avoidance tests was performed too early in development, while learning/acquisition tests and retention/memory tests were not conducted.
[Show full text]
(12) United States Patent (10) Patent No.: US 8.598,119 B2 Mates Et Al
US008598119B2 (12) United States Patent (10) Patent No.: US 8.598,119 B2 Mates et al. (45) Date of Patent: Dec. 3, 2013 (54) METHODS AND COMPOSITIONS FOR AOIN 43/00 (2006.01) SLEEP DSORDERS AND OTHER AOIN 43/46 (2006.01) DSORDERS AOIN 43/62 (2006.01) AOIN 43/58 (2006.01) (75) Inventors: Sharon Mates, New York, NY (US); AOIN 43/60 (2006.01) Allen Fienberg, New York, NY (US); (52) U.S. Cl. Lawrence Wennogle, New York, NY USPC .......... 514/114: 514/171; 514/217: 514/220; (US) 514/229.5: 514/250 (58) Field of Classification Search (73) Assignee: Intra-Cellular Therapies, Inc. NY (US) None See application file for complete search history. (*) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 (56) References Cited U.S.C. 154(b) by 215 days. U.S. PATENT DOCUMENTS (21) Appl. No.: 12/994,560 6,552,017 B1 4/2003 Robichaud et al. 2007/0203120 A1 8, 2007 McDevitt et al. (22) PCT Filed: May 27, 2009 FOREIGN PATENT DOCUMENTS (86). PCT No.: PCT/US2O09/OO3261 S371 (c)(1), WO WOOOf77OO2 * 6, 2000 (2), (4) Date: Nov. 24, 2010 OTHER PUBLICATIONS (87) PCT Pub. No.: WO2009/145900 Rye (Sleep Disorders and Parkinson's Disease, 2000, accessed online http://www.waparkinsons.org/edu research/articles/Sleep PCT Pub. Date: Dec. 3, 2009 Disorders.html), 2 pages.* Alvir et al. Clozapine-Induced Agranulocytosis. The New England (65) Prior Publication Data Journal of Medicine, 1993, vol. 329, No. 3, pp. 162-167.* US 2011/0071080 A1 Mar.
[Show full text]
Journal of Psychopharmacology
Journal of Psychopharmacology http://jop.sagepub.com/ British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders SJ Wilson, DJ Nutt, C Alford, SV Argyropoulos, DS Baldwin, AN Bateson, TC Britton, C Crowe, D-J Dijk, CA Espie, P Gringras, G Hajak, C Idzikowski, AD Krystal, JR Nash, H Selsick, AL Sharpley and AG Wade J Psychopharmacol 2010 24: 1577 originally published online 2 September 2010 DOI: 10.1177/0269881110379307 The online version of this article can be found at: http://jop.sagepub.com/content/24/11/1577 Published by: http://www.sagepublications.com On behalf of: British Association for Psychopharmacology Additional services and information for Journal of Psychopharmacology can be found at: Email Alerts: http://jop.sagepub.com/cgi/alerts Subscriptions: http://jop.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav Citations: http://jop.sagepub.com/content/24/11/1577.refs.html Downloaded from jop.sagepub.com at University of Otago Library on March 11, 2011 Original Paper British Association for Psychopharmacology consensus statement on evidence-based Journal of Psychopharmacology treatment of insomnia, parasomnias and 24(11) 1577–1600 ! The Author(s) 2010 circadian rhythm disorders Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/0269881110379307 jop.sagepub.com SJ Wilson1, DJ Nutt2, C Alford3, SV Argyropoulos4, DS Baldwin5, AN Bateson6, TC Britton7, C Crowe8, D-J Dijk9, CA Espie10, P Gringras11, G Hajak12, C Idzikowski13, AD Krystal14, JR Nash15, H Selsick16, AL Sharpley17 and AG Wade18 Abstract Sleep disorders are common in the general population and even more so in clinical practice, yet are relatively poorly understood by doctors and other health care practitioners.
[Show full text]
Emerging Anti-Insomnia Drugs: Tackling Sleeplessness and the Quality of Wake Time
REVIEWS Emerging anti-insomnia drugs: tackling sleeplessness and the quality of wake time Keith A. Wafford* and Bjarke Ebert‡ Abstract | Sleep is essential for our physical and mental well being. However, when novel hypnotic drugs are developed, the focus tends to be on the marginal and statistically significant increase in minutes slept during the night instead of the effects on the quality of wakefulness. Recent research on the mechanisms underlying sleep and the control of the sleep–wake cycle has the potential to aid the development of novel hypnotic drugs; however, this potential has not yet been realized. Here, we review the current understanding of how hypnotic drugs act, and discuss how new, more effective drugs and treatment strategies for insomnia might be achieved by taking into consideration the daytime consequences of disrupted sleep. Primary insomnia Humans spend approximately one-third of their lifetime Insomnia is defined as difficulty in initiating and/or Patients who suffer from sleeping, but we still know relatively little about why this maintaining sleep. The incidence of insomnia in the gen- sleeplessness for at least process is so critical for every living animal. Current eral population is between 10–30%, and approximately 1 month that cannot be thinking suggests that waking activity is relatively 50% of the cases complain of serious daytime conse- attributed to a medical, dynamic in terms of using the body’s resources: breaking quences, such as inability to concentrate, reduced energy psychiatric or an environmental cause (such as drug abuse or down proteins, gathering information and expending and memory problems. When this persists for more medications).
[Show full text]
WO 2010/065547 Al
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 10 June 2010 (10.06.2010) WO 2010/065547 Al (51) International Patent Classification: (74) Agents: AMII, Lisa, A. et al.; Morrison & Foerster LLP, A61M 15/00 (2006.01) A61M 9/00 (2006.01) 755 Page Mill Road, Palo Alto, CA 94304-1018 (US). A61M 16/00 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/US2009/066272 AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (22) International Filing Date: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 1 December 2009 (01 .12.2009) HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (25) Filing Language: English KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (26) Publication Language: English NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (30) Priority Data: SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, 61/1 19,015 1 December 2008 (01 .12.2008) US TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant (for all designated States except US): MAP (84) Designated States (unless otherwise indicated, for every PHARMACEUTICALS, INC. [US/US]; 2400 Bayshore kind of regional protection available): ARIPO (BW, GH, Parkway, Suite 200, Mountain View, CA 94043 (US).
[Show full text]
(12) Patent Application Publication (10) Pub. No.: US 2015/0290181 A1 Lee Et Al
US 201502901 81A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2015/0290181 A1 Lee et al. (43) Pub. Date: Oct. 15, 2015 (54) COMBINATION OF EFFECTIVE (52) U.S. Cl. SUBSTANCES CAUSING SYNERGISTIC CPC ............. A6 IK3I/445 (2013.01); A61 K3I/I66 EFFECTS OF MULTIPLE TARGETING AND (2013.01); A61 K3I/505 (2013.01); A61 K USE THEREOF 36/38 (2013.01); A61K 45/06 (2013.01); A61 K 36/744 (2013.01); A61K 36/69 (2013.01); (75) Inventors: Doo Hyun Lee, Seoul (KR); Sunyoung A61K 31/198 (2013.01); A61K 36/40 Cho, Gyeonggi-do (KR) (2013.01); A61 K36/884 (2013.01) (73) Assignee: VIVOZONE, INC., Seoul (KR) (57) ABSTRACT Disclosed are a combination of active components inducing (21) Appl. No.: 14/128,616 synergistic effects of multi-targeting and a use thereof. More particularly, disclosed are a functional food composition, a (22) PCT Filed: Jun. 28, 2012 cosmetic composition, a pain-suppressive composition, and a composition for treatment or prevention of pruritus or atopic (86). PCT No.: PCT/KR2O12/OOS145 dermatitis, which comprise as active components, two or S371 (c)(1), more components selected from a group consisting of (a) a (2), (4) Date: Jan. 16, 2014 5-hydroxytryptamine subtype 2 (5-HT2) receptor antagonist; (b) a P2X receptor antagonist; and (c) any one of a glycine (30) Foreign Application Priority Data receptor agonist, a glycine transporter (GlyT) antagonist, a gamma-aminobutyric acid (GABA) receptor agonist, and a Jun. 28, 2011 (KR) ........................ 10-2011-0063.289 GABA transporter 1 (GAT1) antagonist. The multi-targeting composite composition (specifically, natural Substances com Publication Classification posite composition) has synergistic effects, and thus a treat ment using a combination of respective components may (51) Int.
[Show full text]
Method of Treating Sleep Disorders Using Eplivanserin
(19) & (11) EP 2 186 511 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 19.05.2010 Bulletin 2010/20 A61K 31/15 (2006.01) A61P 25/00 (2006.01) (21) Application number: 08291063.9 (22) Date of filing: 13.11.2008 (84) Designated Contracting States: • Rein, Werner AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Paris (FR) HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT • Verpillat, Patrice RO SE SI SK TR Paris (FR) Designated Extension States: • Weinling, Estelle AL BA MK RS Paris (FR) (71) Applicant: Sanofi-Aventis (74) Representative: Gaslonde, Aude et al 75013 Paris (FR) Sanofi-Aventis Département Brevets (72) Inventors: 174, Avenue de France • Prieur, Amélie 75013 Paris (FR) Paris (FR) (54) Method of treating sleep disorders using eplivanserin (57) Methodfor treating sleep disorders by using epli- and safe use of eplivanserin Method of promoting the vanserin use of eplivanserin Method of providing eplivanserin. Article of manufacture and package. Method of managing the risk to allow an effective EP 2 186 511 A1 Printed by Jouve, 75001 PARIS (FR) EP 2 186 511 A1 Description [0001] The instant invention relates to a method of treating sleep disorders by using eplivanserin or pharmaceutically acceptable salts or esters thereof in patients not displaying a prior history of diverticulitis. 5 [0002] The instant invention relates to a method of providing eplivanserin or pharmaceutically acceptable salts or esters thereof. [0003] The instant invention also relates to a method of managing the risk of diverticulitis to allow an effective and safe use of eplivanserin or pharmaceutically acceptable salts or esters thereof of, in the treatment of patients treated for sleep disorders.
[Show full text]
Novel Implications for Lost Serotonin Transporter Function on Platelet
Novel implications of lost serotonin transporter function on platelet biology By Kendra Helen Oliver Dissertation Submitted to the Faculty of the Graduate School of Vanderbilt University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in Pharmacology December, 2016 Nashville, Tennessee Approved: Date: _______________________________________________ __________________ Jonathan Schoenecker, M.D., Ph.D. (Chair) _______________________________________________ __________________ Heidi E. Hamm, Ph.D. _______________________________________________ __________________ Ana M.D. Carneiro, Ph.D. _______________________________________________ __________________ Digna R. Velez Edwards Ph.D., M.S. _______________________________________________ __________________ Vsevolod Gurevich, Ph.D. DEDICATION To my parents, Michael Cherry and Kimberlee Oliver, to my brilliant sister, Briana Oliver, and to my partner in crime, Dr. Max Joffe. ii ACKNOWLEDGEMENTS There are so many wonderful people that have I would like to thank for their support and guidance during this challenging and daunting process. Most importantly, I would like to thank my mentors, Dr. Heidi E Hamm and Dr. Ana M.D. Carneiro. Dr. Carneiro has pushed me beyond my limits and has provided my scholarly foundation. Dr. Hamm has also been an outstanding mentor and role model as a scientist. I would also like to thank my committee members for their guidance during my scientific scholarship. The direction and administrative support received from Dr. Christine Konrodi and Karen Geig, and Dr. Joey Barrett, has been extraordinary, and for that I am very thankful. Additionally, I would like to thank and acknowledge my lab members. In particular, Dr. Matthew Duvernay has helped me navigate the world of platelet biology and Dr. Ali Kali for his support and encouragement.
[Show full text]
Serotonin Transporter 5-HTT; SERT; SLC6A4
Serotonin Transporter 5-HTT; SERT; SLC6A4 Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves. Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available. www.MedChemExpress.com 1 Serotonin Transporter Inhibitors (S)-Venlafaxine (±)-Duloxetine hydrochloride Cat. No.: HY-B0196B ((Rac)-Duloxetine hydrochloride) Cat. No.: HY-B0161E (S)-Venlafaxine is the (S)-configuration of (±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is Venlafaxine. Venlafaxine is an orally active, the racemate of Duloxetine hydrochloride. potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant agent. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mg Amitifadine hydrochloride Amitriptyline hydrochloride (DOV-21947 hydrochloride; EB-1010 hydrochloride) Cat. No.: HY-18332A Cat. No.: HY-B0527A Amitifadine hydrochloride is a Amitriptyline hydrochloride is an inhibitor of serotonin-norepinephrine-dopamine reuptake serotonin reuptake transporter (SERT) and inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for noradrenaline reuptake transporter (NET), with Kis serotonin, norepinephrine and dopamine in HEK 293 of 3.45 nM and 13.3 nM for human SERT and NET, cells , respectively.
[Show full text]
5-HT2A Receptors in the Central Nervous System the Receptors
The Receptors Bruno P. Guiard Giuseppe Di Giovanni Editors 5-HT2A Receptors in the Central Nervous System The Receptors Volume 32 Series Editor Giuseppe Di Giovanni Department of Physiology & Biochemistry Faculty of Medicine and Surgery University of Malta Msida, Malta The Receptors book Series, founded in the 1980’s, is a broad-based and well- respected series on all aspects of receptor neurophysiology. The series presents published volumes that comprehensively review neural receptors for a specific hormone or neurotransmitter by invited leading specialists. Particular attention is paid to in-depth studies of receptors’ role in health and neuropathological processes. Recent volumes in the series cover chemical, physical, modeling, biological, pharmacological, anatomical aspects and drug discovery regarding different receptors. All books in this series have, with a rigorous editing, a strong reference value and provide essential up-to-date resources for neuroscience researchers, lecturers, students and pharmaceutical research. More information about this series at http://www.springer.com/series/7668 Bruno P. Guiard • Giuseppe Di Giovanni Editors 5-HT2A Receptors in the Central Nervous System Editors Bruno P. Guiard Giuseppe Di Giovanni Faculté de Pharmacie Department of Physiology Université Paris Sud and Biochemistry Université Paris-Saclay University of Malta Chatenay-Malabry, France Msida MSD, Malta Centre de Recherches sur la Cognition Animale (CRCA) Centre de Biologie Intégrative (CBI) Université de Toulouse; CNRS, UPS Toulouse, France The Receptors ISBN 978-3-319-70472-2 ISBN 978-3-319-70474-6 (eBook) https://doi.org/10.1007/978-3-319-70474-6 Library of Congress Control Number: 2017964095 © Springer International Publishing AG 2018 This work is subject to copyright.
[Show full text]
CUSTOMS TARIFF - SCHEDULE 99 - I
CUSTOMS TARIFF - SCHEDULE 99 - i Chapter 99 SPECIAL CLASSIFICATION PROVISIONS - COMMERCIAL Notes. 1. The provisions of this Chapter are not subject to the rule of specificity in General Interpretative Rule 3 (a). 2. Goods which may be classified under the provisions of Chapter 99, if also eligible for classification under the provisions of Chapter 98, shall be classified in Chapter 98. 3. Goods may be classified under a tariff item in this Chapter and be entitled to the Most-Favoured-Nation Tariff or a preferential tariff rate of customs duty under this Chapter that applies to those goods according to the tariff treatment applicable to their country of origin only after classification under a tariff item in Chapters 1 to 97 has been determined and the conditions of any Chapter 99 provision and any applicable regulations or orders in relation thereto have been met. 4. The words and expressions used in this Chapter have the same meaning as in Chapters 1 to 97. Issued January 1, 2016 99 - 1 CUSTOMS TARIFF - SCHEDULE Tariff Unit of MFN Applicable SS Description of Goods Item Meas. Tariff Preferential Tariffs 9901.00.00 Articles and materials for use in the manufacture or repair of the Free CCCT, LDCT, GPT, UST, following to be employed in commercial fishing or the commercial MT, MUST, CIAT, CT, harvesting of marine plants: CRT, IT, NT, SLT, PT, COLT, JT, PAT, HNT, Artificial bait; KRT: Free Carapace measures; Cordage, fishing lines (including marlines), rope and twine, of a circumference not exceeding 38 mm; Devices for keeping nets open; Fish hooks; Fishing nets and netting; Jiggers; Line floats; Lobster traps; Lures; Marker buoys of any material excluding wood; Net floats; Scallop drag nets; Spat collectors and collector holders; Swivels.
[Show full text]