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CELEBRATION of SCIENCE COVID Lessons Learned: Scientific and Community Impact 72ND MEETING OF THE MGH SCIENTIFIC ADVISORY COMMITTEE Wednesday, April 7 & Thursday, April 8, 2021 Table of Contents 2–3 90–229 Meeting Agenda Department Reports 4 90 Anesthesia, Critical Care and P ain Medicine Martin Research Prizes 94 Cancer Center 5 98 The Consortia for Improving Medicine with Innovation Howard M. Goodman Fellowship & Technology 6–7 102 Dermatology SAC Membership 106 Emergency Medicine 110 Medicine 8–9 122 Molecular Biology ECOR Membership 126 Neurology 10–61 132 Neurosurgery MGRI Executive Report 136 Nursing 140 Obstetrics and Gynecology 62–69 148 Ophthalmology Programmatic Report 154 Oral and Maxillofacial 62 Center for Diversity Surgery and Inclusion (CDI) 158 Orthopaedics 64 Center for Faculty 168 Otolaryngology, Head and Development (CFD) Neck Surgery 176 Pathology 70–89 180 Pediatrics Thematic Center Report 194 Psychiatry 70 Center for Computational 198 Radiation Oncology and Integrative Biology 204 Radiology 74 Center for Genomic 208 Ragon Institute of MGH, Medicine MIT & Harvard 78 Center for Regenerative 210 Surgery Medicine 220 Urology 82 Center for Systems Biology 86 Wellman Center for Photomedicine Front cover photo thanks to Dylan Parsons, BS, Ragon Institute of MGH, MIT and Harvard (dylanparsonsphotography.com) Celebration of Science 3 Agenda Wednesday, April 7, 2021 11:00 AM – 1:00 PM Virtual Poster Session 2:00 – 5:00 PM Celebration Of Science Welcome and Opening Remarks Peter L. Slavin, MD, President, MGH ECOR Report David E. Fisher, MD, PhD, Chair, Executive Committee on Research (ECOR) Class of 2021 MGH Research Scholars Susan A Slaugenhaupt, PhD, Scientific Director, Mass General Research Institute Martin Prize for Fundamental Research Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer Martin Aryee, PhD, Assistant Professor, Pathology Martin Prize for Clinical Research Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis Sabrina Paganoni, MD, PhD, Assistant Professor, Physical Medicine and Rehabilitation Howard M. Goodman Fellowship Development and Application of Therapeutic Genome Editing Technologies Benjamin Kleinstiver, PhD, Assistant Professor, Pathology / Center for Genomic Medicine Howard M. Goodman Fellowship Neuro-immune Circuits Controlling the Initiation of Allergic Immunity Caroline Sokol, MD, PhD, Assistant Professor, Medicine / Rheumatology, Allergy and Immunology Thursday, April 8, 2021 — COVID Lessons Learned: Scientific and Community Impact 10:00 AM – 12:00 PM COVID-19, Health Equity, and Developing the Next Generation of Population and Health Care Delivery Team Scientists Welcome Peter L. Slavin, MD, President, MGH Part I: Developing the next generation Completing the Translational Research Arc at MGH from Discovery to Delivery Science and Health Equity Steve Bartels MD, MS., Director, The Mongan Institute Impact of COVID-19 on Vulnerable Research Faculty- Challenges and Opportunities Katrina A. Armstrong, MD, Physician-in-Chief, Department of Medicine Advancing Equity and Diversity and Growing the Pipeline of the Next Generation of Population and Health Care Delivery Scientists: the MGH COVID-Corps Research Internship Program Long Nguyen MD, MS & Aswita Tan-McGrory, MBA, MSPH Moderated Q & A Session Dr. Bartels 4 Agenda Part II: Examples of COVID-19 Population and Health Care Delivery Team Science Data Science: Rapid Implementation of Realtime COVID-19 Clinical Epidemiology: • Mobile Epidemiology of COVID-19 and the Coronavirus Pandemic Epidemiology (COPE) Consortium Andrew Chan MD, MPH & David Drew PhD • Rapid Observational Data Collection for COVID-19 Research at Mass General Brigham Ingrid Bassett, MD, MPH & Virginia Triant, MD, MPH Data Science: Simulation Modeling of the Clinical and Economic Outcomes of COVID-19 Prevention and Treatment: From Homeless Adults in Boston to WHO Low and Middle Income Country Vaccine Distribution Krishna Reddy, MD Delivery Science: COVID-19, Health Disparities, and Interventions for Vulnerable Populations, a Panel Discussion Margarita Alegría, PhD, Efren Flores, MD, Julie Levison, MD, MPH & Ali Raja, MD, MBA, MPH COVID-19: Global Health Equity in Pandemic Response Louise Ivers, MD, MPH Research on Interventions for COVID Related Stress Luana Marques, PhD Moderated Q and A Dr. Bartels 12:00 – 1:00 PM Lunch 1:00 – 2:15 PM COVID-19 Innovation Moderator: Galit Alter, PhD, Ragon Institute of MGH, MIT and Harvard Keynote: COVID-19 From Bench to Globe Dr. Alter Technology Gary Tearney, MD, PhD Diagnostics A. John Iafrate, MD, PhD Keith Flaherty, MD Immunology Richelle Charles, MD Vaccine Trials Ricky Mofsen, DO Moderated Q&A Dr. Alter 2:15 – 2:45 PM Executive Session (SAC members only) 2:45 – 3:15 PM Debrief: Research Institute Steering Committee & SAC Members (closed) Celebration of Science 5 Martin Research Prizes 2021 MARTIN RESEARCH PRIZE FOR CLINICAL AND FUNDAMENTAL RESEARCH The Martin Research Prizes were established to honor Joseph B. Martin, MD, PhD, who was Dean of Harvard Medical School from July 1997 to July 2007. Prior to becoming Dean, Dr. Martin was Chief of the Neurology Service at MGH. Each year, ECOR awards two $100,000 Martin Research Prizes to recognize outstanding research papers published by MGH investigators in Fundamental research and Clinical research. Sabrina Paganoni, MD, PhD Martin Aryee, PhD Assistant Professor, Assistant Professor, Physical Medicine and Pathology Rehabilitation Large-Scale Topological Changes Restrain Malignant Trial of Sodium Phenylbutyrate-Taurursodiol for Progression in Colorectal Cancer Amyotrophic Lateral Sclerosis It has been known for over 100 years that tumor cells The CENTAUR trial is the first trial to demonstrate positive look different than normal cells under the microscope. effects of an investigational product on both functional Pathologists, for example, use the presence of misshapen outcomes and survival in people with ALS. The CENTAUR nuclei as a key feature when diagnosing cancer in a patient. trial is also noteworthy as a unique collaboration between Despite this, the relationship between these microscopic academia, foundations and industry and includes design features and the function of cancer cells have remained features that are likely to have a major impact on the design unknown. This study relates visible cancer cell aberrations of future ALS trials. The positive results of the CENTAUR to changes in the physical organization of DNA and shows trial have the potential to change clinical practice and that it surprisingly occurs in both cancer cells and some improve the natural history of ALS. Trial results were normally aging cells. The entire three-dimensional structure published in the New England Journal of Medicine. of the DNA in these cells is reorganized over time as they divide. About half of the genome becomes physically compacted which serves to turn off genes located in these regions. Suppressing the activity of these genes helps prevent the development of cancer by reducing the cell’s ability to proliferate and metastasize. Even though cancer cells also undergo this transformation, they adapt other mechanisms to overcome the tumor suppressive effects and promote tumor growth. A key surprising finding of the study is that the well-known visible abnormalities in the nuclei of cancer cells may not be associated with cancer progression, but more likely represent a failed attempt to halt cancer development. A better understanding of this newly described tumor suppressive mechanism may open up future avenues for exploiting it to inhibit tumor progression. 6 Howard M. Goodman Fellowship 2021 HOWARD M. GOODMAN FELLOWSHIP The Howard M. Goodman Fellowship honors Howard M. Goodman, PhD, founder of the Department of Molecular Biology at Massachusetts General Hospital in 1982 and chief of that department until 2004. Dr. Goodman’s guiding principle was that great science should not be encumbered by the continual need to convince the world concerning the merit of an individual scientific vision. He believed in choosing scientists of demonstrated excellence and giving them the resources to pursue their goals with vigor, a model that was resoundingly successful. Each year a Goodman Fellow is chosen from the MGH community to honor that legacy and to support the pursuit of excellence by young scientists of uncommon passion and ability. Caroline Sokol, MD, PhD Benjamin Kleinstiver, PhD Assistant Professor of Medicine, Assistant Professor of Pathology, Rheumatology, Allergy, Center for Genomic Medicine and Immunology Development and Application of Therapeutic Genome Neuro-immune circuits controlling the initiation of Editing Technologies allergic immunity Most human diseases are caused by faulty genetic Allergic diseases afflict 40% of the United States sequences. The recent discovery that CRISPR enzymes population, but it is unknown how allergens are sensed enable researchers to perform custom DNA edits offers by the body. Allergens lead to immune activation, but hope for correcting the underlying genetic defects that paradoxically they do not directly activate immune cells. cause devastating disorders. However, naturally occurring Our laboratory recently discovered that allergens are first CRISPR enzymes, which evolved as part of bacterial detected by the sensory nervous system leading to itch immune systems, are not optimally suited for the safe and and the release of neuropeptides that then activate innate effective treatment of patients.
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