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Biomédica 2018;38:451-2 Biomédica Revista Del Instituto Nacional De Salud Volumen 38, No I-ISSN 2590-7379 (En línea) Biomédica 2018;38:451-2 Biomédica Revista del Instituto Nacional de Salud Volumen 38, No. 3 - Septiembre de 2018 Bogotá, D.C., Colombia, S.A. 452 Portada: 0 304 Biomédica Instituto Nacional de Salud Volumen 38, No. 3 - Bogotá, D.C., Colombia - Septiembre de 2018 Comité Editorial EDITORES LUIS ALBERTO GÓMEZ CARLOS ARTURO HERNÁNDEZ RUBÉN SANTIAGO NICHOLLS Instituto Nacional de Salud Instituto Nacional de Salud Organización Panamericana de la Salud Bogotá, D.C., Colombia Bogotá, D.C., Colombia Washington, D.C., Estados Unidos EDITORES ASOCIADOS ENRIQUE ARDILA LEONARD MUNSTERMANN Bogotá, D.C., Colombia Yale University School of Medicine New Haven, CT, Estados Unidos JOSÉ DE JESÚS MORENO-MONTOYA Universidad El Bosque OMAR SEGURA Bogotá, D.C., Colombia Federación Médica Colombiana Bogotá, D.C., Colombia JULIÁN ALFREDO FERNÁNDEZ-NIÑO Universidad del Norte ORLANDO TORRES-FERNÁNDEZ Barranquilla, Colombia Instituto Nacional de Salud Bogotá, D.C., Colombia MIGUEL A. GUZMÁN Investigador Emérito RAÚL PARDO Instituto Nacional de Salud Instituto Nacional de Salud Bogotá, D.C., Colombia Bogotá, D.C., Colombia Comité Científico ARNOLDO BARBOSA ANDRÉS DE FRANCISCO JOHN MARIO GONZÁLEZ Universidad del Tolima Organización Mundial de la Salud Universidad de los Andes Ibagué, Colombia Ginebra, Suiza Bogotá, D.C., Colombia ANTONIO BERMÚDEZ FERNANDO DE LA HOZ FELIPE GUHL Instituto Nacional de Salud Universidad Nacional de Colombia Universidad de los Andes Bogotá, D.C., Colombia Bogotá, D.C., Colombia Bogotá, D.C., Colombia JORGE H. BOTERO JOSÉ LUIS DI FABIO ANTONIO IGLESIAS Universidad de Antioquia Organización Panamericana de la Salud Universidad Nacional de Colombia Medellín, Colombia Washington, D.C., Estados Unidos Bogotá, D.C., Colombia JORGE HERNANDO DONADO GUSTAVO ALONSO CABRERA JORGE JARA Universidad de Antioquia Universidad Pontificia Bolivariana Centers for Disease Control and Medellín, Colombia Medellín, Colombia Prevention, Regional Office for CARLOS ANDRÉS FANDIÑO Central America and Panama, VÍCTOR CÁRDENAS Universidad del Valle CDC-CAP University of Texas Cali, Colombia Ciudad de Guatemala, Guatemala El Paso, TX, Estados Unidos JOSÉ FIGUEROA ERNESTO JARAMILLO ALBERTO CONCHA-EASTMAN World Health Organization Organización Mundial de la Salud Guatapé, Colombia Ginebra, Suiza Ginebra, Suiza OILO UÉLLAR Z C LUIS FERNANDO GARCÍA MARCELO LABRUNA Academia Nacional de Medicina Universidad de Antioquia Universidade de São Paulo Bogotá, D.C., Colombia Medellín, Colombia São Paulo, Brasil LUIS GABRIEL CUERVO ALBERTO GÓMEZ JAIRO LIZARAZO Organización Panamericana Pontificia Universidad Javeriana Hospital Universitario Erasmo Meoz de la Salud Bogotá, D.C., Colombia Cúcuta, Colombia Washington, D.C., Estados Unidos ENRIQUE GONZÁLEZ JUAN GUILLERMO MCEWEN PATRICIA DEL PORTILLO University of Texas Health Science Center Corporación para Investigaciones Corpogén at San Antonio Biológicas Bogotá, D.C., Colombia San Antonio, TX, Estados Unidos Medellín, Colombia 291 ROBERTO MENDOZA VÍCTOR E. REYES NANCY GORE SARAVIA The Hospital for Sick Children University of Texas Medical Branch Centro Internacional de Entrenamiento Toronto, Ontario, Canada Galveston, TX, Estados Unidos e Investigaciones Médicas Cali, Colombia ÁLVARO MONCAYO GUSTAVO C. ROMÁN Universidad de los Andes Methodist Neurological Institute ROBERT TESH Bogotá, D.C., Colombia Houston, TX, Estados Unidos University of Texas EDRO OMERO GALVESTON, TX, ESTADOS UNIDOS RICARDO NEGRONI P R Ludwig Center for Cancer Research Hospital de Infecciosas BRUNO TRAVI Francisco Javier Muñiz University of Lausanne University of Texas Buenos Aires, Argentina Lausana, Suiza Galveston, TX, Estados Unidos ÁLVARO RUIZ MARÍA TERESA OCHOA GUSTAVO VALBUENA Pontificia Universidad Javeriana University of California Los Ángeles University of Texas Bogotá, D.C., Colombia Los Ángeles, CA, Estados Unidos Galveston, TX, Estados Unidos GIOCONDA SAN BLAS JUAN P. OLANO Instituto Venezolano de JUAN MIGUEL VILLALOBOS University of Texas Medical Branch Investigaciones Científicas Universidade Federal de Rondônia Galveston, TX, Estados Unidos Caracas, Venezuela Porto Velho, Brasil BLANCA RESTREPO ÁLVARO SANABRIA MOISÉS WASSERMAN University of Texas Hospital Pablo Tobón Uribe Investigador Emérito Brownsville, TX, Estados Unidos Medellín, Colombia Instituto Nacional de Salud Universidad de la Sabana Universidad Nacional de Colombia GERZAÍN RODRÍGUEZ Chía, Colombia Bogotá, D.C., Colombia Investigador Emérito Instituto Nacional de Salud RICARDO SÁNCHEZ Universidad de la Sabana Universidad Nacional de Colombia Bogotá, D.C., Colombia Bogotá, D.C., Colombia CARLOS ARTURO HERNÁNDEZ LINDA GRACE MOLANO MARTHA RENZA ELIZABETH GUZMÁN JOHANNA MORALES Edición y corrección de estilo Asistencia editorial Corrección de estilo Mercadeo digital Diagramación © Instituto Nacional de Salud La revista Biomédica del Instituto Nacional de Salud es una publicación trimestral, eminentemente científica. Está amparada por la resolución número 003768 de 1981, emanada del Ministerio de Gobierno, y con tarifa postal reducida según resolución número 1128 del 5 de mayo de 1982. Ninguna publicación, nacional o extranjera, podrá reproducir ni traducir sus artículos ni sus resúmenes sin previa autorización escrita del editor. Ni la revista, ni el Instituto asumen responsabilidad alguna por los puntos de vista expresados por los autores. La revista no publicará ningún tipo de propaganda comercial. Los nombres de equipos, materiales y productos manufacturados que eventualmente puedan mencionarse, no implican recomendación ni propaganda para su uso y sólo se mencionan como identificación genérica. La revista Biomédica aparece reseñada en Index Medicus/Medline de la National Library of Medicine, en el Science Citation Index Expanded (also known as SciSearch®) y Journal Citation Reports/Science Edition de Thomson Scientific, en SciELO Colombia (Scientific Electronic Library Online), en el índice de la Literatura Latinoamericana en Ciencias de la Salud (LILACS), en la Red de Revistas Científicas de América Latina, el Caribe, España y Portugal (RedAlyC), en el Índice Mexicano de Revistas Biomédicas Latinoamericanas (Imbiomed), en Scopus de Elsevier B.V., en el Sistema de Información Bibliográfica Regional Andina (SIBRA), en CAB Abstracts, Review of Medical and Veterinary Entomology, y forma parte del Índice Nacional de Publicaciones Seriadas Científicas y Tecnológicas Colombianas de Colciencias y del Índice Latinoamericano de Revistas Científicas y Tecnológicas (LATINDEX). INSTITUTO NACIONAL DE SALUD Avenida Calle 26 No. 51-20 Apartado aéreo 80334 y 80080 Bogotá, D.C., Colombia, S.A. URL: http://www.ins.gov.co [email protected] 292 Contenido Editorial Análisis de costo-utilidad en Colombia del tratamiento Polimorfismo genético en poblaciones colombianas integral del carcinoma de seno con reconstrucción y su importancia en salud pública inmediata frente a la reconstrucción diferida Ignacio Briceño-Balcázar .................................................... 295 Ana Helena Perea, Diego Rosselli ..................................... 363 Presentación de caso Citometría de flujo en reticulocitos de sangre periférica como indicador de inestabilidad cromosómica en Histoplasmosis diseminada como manifestación inicial pacientes con gliomas de alto grado del linfoma linfocítico de células pequeñas Lina Marcela Barrera, León Darío Ortiz, Hugo Grisales, Nhora Silva, Natalia Calvache, Elizabeth Arrieta, Mauricio Rojas, Mauricio Camargo .................................... 379 Juan Carlos Bravo, Camilo Salazar, Joaquín Rosales, Francisco Jaramillo, Juan Guillermo Restrepo ................... 298 Modulación de la neurogénesis y la gliogénesis en Mioclonías inducidas por salbutamol la isquemia cerebral mediante una terapia basada María Alejandra Montoya-Giraldo, Dayana Vanessa en la interferencia de CDK5 Montoya, David Alexander Atehortúa,Jefferson Juan Ignacio Muñoz-Manco, Johanna Andrea Antonio Buendía, Andrés Felipe Zuluaga ........................... 303 Gutiérrez-Vargas, Gloria Patricia Cardona-Gómez ............ 388 Variante patogénica homocigótica del gen BBS10 Utilización de dos antibióticos genéricos en un en un paciente con síndrome de Bardet-Biedl hospital de tercer nivel en Bogotá Yaqueline Ladino, Johanna Galvis, Diana Yasnó, José Julián López, Yira Cortázar, Ángela Acosta, Adriana Ramírez, Orietta Ivonne Beltrán ............................ 308 Claudia Marcela Vargas-Peláez, Francisco Rossi .............. 398 Artículo original Caracterización de las potenciales interacciones Polimorfismos de los genes JAG1, MEF2C y BDNF farmacológicas en pacientes de una unidad de cuidados asociados con la densidad mineral ósea en mujeres intensivos en un hospital de tercer nivel de Bogotá del norte de México Marcela Hernández, Gabriel Tribiño, ............................................................. 407 Sandra Marlen González-Peña, Eduardo Carlos Bustamante Campos-Góngora, Hilda Guadalupe Ávila-Rodríguez, Patrones de prescripción de fármacos Erik Ramírez-López, Rafael Velázquez-Cruz, antiparkinsonianos en un grupo de pacientes Zacarías Jiménez-Salas ..................................................... 320 de Colombia, 2015 Polimorfismos de un solo nucleótido representativos Jorge Enrique Machado-Alba, Luis Felipe Calvo-Torres, para los alelos clásicos del antígeno leucocitario humano Andrés Gaviria-Mendoza, Juan Daniel Castrillón-Spitia ...... 417 en familias
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