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JMSCR Vol||09||Issue||03||Page 21-26||March 2021 JMSCR Vol||09||Issue||03||Page 21-26||March 2021 http://jmscr.igmpublication.org/home/ ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v9i3.05 Scurvy Yes, it exists Authors Samira Aggoune, Hachemi Maouche Departement of Pediatric’s, University Teaching Hospital, Belfort Algier’s. Algeria Pediatrician, Professor Abstract Scurvy is not gone from the face of the planet. In the past it was seen commonly in sailors and soldiers who had limited access to fresh fruits and vegetables over extended periods. Scurvy still exists today within certain populations, particularly in patients with neurodevelopmental disabilities, psychiatric illness or unusual dietary habits. We describe a case of scurvy occurring appeared in a 4-year-old boy with a special diet such as milk and cookies from a young age, presented in a month earlier: asthenia, diffuse lower-extremity musculoskeletal pain, and refusal to walk. Introduction Case Presentation Scurvy stands out in our minds as something that A four year old boy with history of worsening is so basic and easy to avoid, and yet these people musculoskeletal pain and refusal to walk for one have ended up falling victim to an illness that month. His mother had noticed weight loss, simply should not exist in a developed country. lethargy, anorexia, fatigue and weakness. A bone Humans cannot synthesize vitamin C. It needs to story for which he landed in childhood surgery come from external sources, especially fruits and then the patient was referred to us. In his personal vegetables, or fortified foods. antecedents include the notion of six febrile Scurvy can occur in children whose diet is convulsions brought under Depakine restricted as a consequence of developmental or Physical examination disclosed impaired general socioeconomic circumstances[1,2]. Almost condition (weight loss, severe asthenia, anorexia), exclusively in children with autism, apyretic, hemodynamically stable, weighed 12kg developmental and behavioral issues, (- 2 DS according to the WHO curve) with a size malabsorptive processes, or iron overload, and in of95 cm (between -1 and -2 DS according to the disorders causing dysphagia or impaired WHO curve)mucosal skin examination finds swallowing.[3,4] pallor, gingivitis perifollicular hemorrhages and Until recently, in developed countries, the extensive ecchymoses with increased occurrence of scurvy in children had become a pigmentation involving the lower extremities and historical footnote, with most radiologists having a diffuse onpruritic perifollicular rash. edema of never encountered acase[5]. the lower limbs and feet (Figure 1). On physical Samira Aggoune et al JMSCR Volume 09 Issue 03 March 2021 Page 21 JMSCR Vol||09||Issue||03||Page 21-26||March 2021 examination, with knees and hips flexed in subperiosteal hemorrhage, a dense provisional antalgic posture, he had a marked limp favoring calcification immediately adjacent to the physis the left side and limited abduction and internal and (Frankel line), and an adjacent lucent band more external rotation of the left hip. Neurologic diaphyseal in location (Trummerfeld line) are also examination result was normal but the child was classically described. (Fig 2) listless and indifferent. The patient was started on vitamin C Further laboratory work was sent, which showed supplementation at 100 mg every8 hours for 1 an deficient hypochromic microcytic anemia at week followed by100 mg daily along with iron, 6g/dl of hemoglobin for which he received a blood vitamin D, and a multivitamin. transfusion. Bleeding disorder work up including On hospital day 7, there was a decrease in the prothrombin time, partial thromboplastin time, number of petechia and in pain (the child could sit international normalized ratio (INR), platelet for a few minutes) aggregation tests, and factor assay for factors VII, On day 20: the child became quiet, responsive and XIII and IX were normal. C-reactive protein, playful, disappearance of the pain (the child can coagulation profile, and chemistry including sit down) with persistence of some petechia, calcium, phosphorus, and magnesium were also weight gain (02kg), the child however remained normal. Vitamin C blood test: less than 03µmol always suspicious and apathetic. Rehabilitation /l(normal 23–114 mmol/L), there were no other was started as soon as the pain had subsided. He abnormalities, we even dosed the vitamin d which was discharged with follow-up appointments, returned to 18.9 ng / ml. Given hisprogression of including nutrition and feeding therapy. symptoms to the point of acutely not bearing At his 3-month follow-up, hispain had resolved, weight, additional imaging was done. An and he was ambulating with persistence of a little ultrasound showed trace joint fluid the left hip, stiffness and lameness, persistence of gingivitis Radiographic findings in our case are a and some petechiae in the trunk. Wimberger ring sign, which denotes a thin A marked improvement was noted on the sclerotic cortex surrounding a lucent epiphysis. psychological level since the child spoke laughed Periosteal new bone formation secondary to and even played with us during the consultation. Fig1a: Gingivitis Fig1b: perifollicular rash, edema Samira Aggoune et al JMSCR Volume 09 Issue 03 March 2021 Page 22 JMSCR Vol||09||Issue||03||Page 21-26||March 2021 b c a A A A a a a d A a Fig 2a: Wimberger’s sign- circular, opaqueradiologic shadow surrounding epiphyseal centres of ossification e A a f A a Fig 2 b: Fraenkel’s line- densezone of provisional calcification; c, f: pencilthin cortices: d: ground glass appearance; e:Pelkan spur Discussion Additional manifestations can include lower Humans cannot synthesize vitamin C, so we extremity edema, splinter hemorrhages, alopecia, depend strictly on exogenous contribution. Fruits poor wound healing, cardiac hypertrophy, and vegetables are the primary dietary source of psychological changes, and conjunctival this essential vitamin. Vitamin C is an essential hemorrhages, among many others.[7] cofactor for collagen synthesis, and defective There have been reports of scurvy re-emerging in collagen synthesis in scurvy leads to characteristic certain special groups. These groups includes dermatologic and skeletal findings. Malfunction in children with oral aversions, cerebral palsy, collagen synthesis is the primary cause of clinical developmental delay, autism, food faddism and manifestations of vitamin C deficiency. Common predominant dairy consumption[8-9]. Although findings include perifollicular hemorrhage, scurvy can occur at any age, the incidence of “corkscrew” hairs, ecchymoses, gingivitis, scurvy peaks in children aged 6-12 months who arthralgias, impaired wound-healing, and are fed a diet deficient in citrus fruits or anemia.[6] vegetables, as well as in elderly populations, who sometimes have "tea-and-toast" diets deficient in Samira Aggoune et al JMSCR Volume 09 Issue 03 March 2021 Page 23 JMSCR Vol||09||Issue||03||Page 21-26||March 2021 vitamin C. Scurvy is uncommon in the neonatal child and helped in clinching the diagnosis in this period.[10] case. Our case was a developmentally normal child The diagnosis of scurvy is primarily based on albeit malnourished. His malnutrition was clinical presentation, x-ray findings of long bones, predominantly due to scarcity of food in general and a history of poor intake of vitamin C. The as well as excessive consumption of exclusive absence of characteristic radiologic changes in the dairy products. context of significant clinical signs of scurvy is Pediatric patients commonly present with not uncommon.[18] musculoskeletal manifestations. With damage to The dosage of serum vitamin C levels is synovial blood vessels and microfractures, there is considered specific but laboratory tests are pain and swelling secondary to subperiosteal insensitive. It is known that serum concentrations hemorrhages and hemarthroses.[11] do not always correspond with tissue storage of A case series from Thailand reported that 96% of ascorbic acid. A reliable indicator of body storage children diagnosed with scurvy presented with is the measure of urinary excretion after inability to walk.[12] intravenous ascorbic acid administration[19]. The Anemia is another hallmark feature of scurvy and prompt resolution of symptoms after substitutive can be multifaceted. Iron deficiency anemia often treatment represents the main evidence to confirm accompanies scurvy in part due to decreased the diagnosis of scurvy[20]. absorption and also due to bleeding Scurvy is preventable disease. Treatment of manifestations. It is a well-known fact that scurvy is based on replenishing the level of vitamin C helps in enhancing iron absorption by vitamin C to counteract the symptoms. There is no reducing iron to ferrous form. Thus in our child established regimen for vitamin C features suggestive of Iron deficiency anemia supplementation in scurvy. Children require at could have likely resulted from lack of vitamin C least 15 mg/day of VC to meet daily metabolic facilitated iron absorption.[13] requirements and prevent clinical/subclinical Our patient had microcytic anemia that required development of ascorbic acid deficiency one blood transfusions. symptoms. The daily allowance recommended for Classic radiographic findings may include white infants is 40 to 50 mg, and for children 1 to 3 line of Fraenkel, which is an irregular, thickened years old, it is 15 mg[21]. It is demonstrated, that white line that appears at the metaphysis and ascorbic acid administration at an
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