New Positron Emission Tomography (PET) Radiopharmaceutical/Tracer Unclassified Codes
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Computed Tomography (CT) National Institutes of Health
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING Computed Tomography (CT) National Institutes of Health What is a computed tomography (CT) scan? The term “computed tomography”, or CT, refers to a computerized x-ray imaging procedure in which a narrow beam of x-rays is aimed at a patient and quickly rotated around the body, producing signals that are processed by the machine’s computer to generate cross- sectional images—or “slices”—of the body. These slices are called tomographic images and contain more detailed information than conventional x-rays. Once a number of successive slices are collected by the machine’s computer, they can be digitally “stacked” together Source: Terese Winslow to form a three-dimensional image of the patient that allows for easier identification and location of basic structures as well as possible tumors or abnormalities. How does CT work? Unlike a conventional x-ray—which uses a fixed x-ray tube—a CT scanner uses a motorized x-ray source that rotates around the circular opening of a donut-shaped structure called a gantry. During a CT scan, the patient lies on a bed that slowly moves through the gantry while the x-ray tube rotates around the patient, shooting narrow beams of x-rays through the body. Instead of film, CT scanners use special digital x-ray detectors, which are located directly opposite the x-ray source. As the x-rays leave the patient, they are picked up by the detectors and transmitted to a computer. Each time the x-ray source completes one full rotation, the CT computer uses sophisticated mathematical techniques to construct a 2D image slice of the patient. -
Acr–Nasci–Sir–Spr Practice Parameter for the Performance and Interpretation of Body Computed Tomography Angiography (Cta)
The American College of Radiology, with more than 30,000 members, is the principal organization of radiologists, radiation oncologists, and clinical medical physicists in the United States. The College is a nonprofit professional society whose primary purposes are to advance the science of radiology, improve radiologic services to the patient, study the socioeconomic aspects of the practice of radiology, and encourage continuing education for radiologists, radiation oncologists, medical physicists, and persons practicing in allied professional fields. The American College of Radiology will periodically define new practice parameters and technical standards for radiologic practice to help advance the science of radiology and to improve the quality of service to patients throughout the United States. Existing practice parameters and technical standards will be reviewed for revision or renewal, as appropriate, on their fifth anniversary or sooner, if indicated. Each practice parameter and technical standard, representing a policy statement by the College, has undergone a thorough consensus process in which it has been subjected to extensive review and approval. The practice parameters and technical standards recognize that the safe and effective use of diagnostic and therapeutic radiology requires specific training, skills, and techniques, as described in each document. Reproduction or modification of the published practice parameter and technical standard by those entities not providing these services is not authorized. Revised 2021 (Resolution 47)* ACR–NASCI–SIR–SPR PRACTICE PARAMETER FOR THE PERFORMANCE AND INTERPRETATION OF BODY COMPUTED TOMOGRAPHY ANGIOGRAPHY (CTA) PREAMBLE This document is an educational tool designed to assist practitioners in providing appropriate radiologic care for patients. Practice Parameters and Technical Standards are not inflexible rules or requirements of practice and are not intended, nor should they be used, to establish a legal standard of care1. -
Submission to the Nuclear Power Debate Personal Details Kept Confidential
Submission to the Nuclear power debate Personal details kept confidential __________________________________________________________________________________________ Firstly I wish to say I have very little experience in nuclear energy but am well versed in the renewable energy one. What we need is a sound rational debate on the future energy requirements of Australia. The calls for cessation of nuclear investigations even before a debate begins clearly shows that emotion rather than facts are playing a part in trying to stop the debate. Future energy needs must be compliant to a sound strategy of consistent, persistent energy supply. This cannot come from wind or solar. Lets say for example a large blocking high pressure weather system sits over the Victorian, NSW land masses in late summer- autumn season. We will see low winds for anything up to a week, can the energy market from the other states support the energy needs of these states without coal or gas? I think not. France has a large investment in nuclear energy and charges their citizens around half as much for it than Germany. Sceptics complain about the costs of storage of waste, they do not suggest what is going to happen to all the costs to the environment when renewing of derelict solar panels and wind turbine infrastructure which is already reaching its use by dates. Sceptics also talk about the dangers of nuclear energy using Chernobyl, Three Mile Island and Fuklushima as examples. My goodness given that same rationale then we should have banned flight after the first plane accident or cars after the first car accident. -
Optical Coherence Tomography (OCT) Anterior Segment of the Eye
Corporate Medical Policy Optical Coherence Tomography (OCT) Anterior Segment of the Eye File Name: optical_coherence_tomography_(OCT)_anterior_segment_of_the_eye Origination: 2/2010 Last CAP Review: 6/2021 Next CAP Review: 6/2022 Last Review: 6/2021 Description of Procedure or Service Optical Coherence Tomography Optical coherence tomography (OCT) is a noninvasive, high-resolution imaging method that can be used to visualize ocular structures. OCT creates an image of light reflected from the ocular structures. In this technique, a reflected light beam interacts with a reference light beam. The coherent (positive) interference between the 2 beams (reflected and reference) is measured by an interferometer, allowing construction of an image of the ocular structures. This method allows cross-sectional imaging a t a resolution of 6 to 25 μm. The Stratus OCT, which uses a 0.8-μm wavelength light source, was designed to evaluate the optic nerve head, retinal nerve fiber layer, and retinal thickness in the posterior segment. The Zeiss Visante OCT and AC Cornea OCT use a 1.3-μm wavelength light source designed specifically for imaging the a nterior eye segment. Light of this wa velength penetrates the sclera, a llowing high-resolution cross- sectional imaging of the anterior chamber (AC) angle and ciliary body. The light is, however, typically blocked by pigment, preventing exploration behind the iris. Ultrahigh resolution OCT can achieve a spatial resolution of 1.3 μm, allowing imaging and measurement of corneal layers. Applications of OCT OCT of the anterior eye segment is being eva luated as a noninvasive dia gnostic and screening tool with a number of potential a pplications. -
Breast Tomosynthesis: the New Age of Mammography Tomosíntesis: La Nueva Era De La Mamografía
BREAST TOMOSYNTHESIS: THE NEW AGE OF MAMMOGRAPHY TOMOSÍNTESIS: LA NUEVA ERA DE LA MAMOGRAFÍA Gloria Palazuelos1 Stephanie Trujillo2 Javier Romero3 SUMMARY Objective: To evaluate the available data of Breast Tomosynthesis as a complementary tool of direct digital mammography. Methods: A systematic literature search of original and review articles through PubMed was performed. We reviewed the most important aspects of Tomosynthesis in breast imaging: Results: 36 Original articles, 13 Review articles and the FDA and American College of Radiology standards were included. Breast Tomosynthesis has showed a positive impact in breast cancer screening, improving the rate of cancer detection EY WORDS K (MeSH) due to visualization of small lesions unseen in 2D (such as distortion of the architecture) Mammography Tomography and it has greater precision regarding tumor size. In addition, it improves the specificity of Diagnosis mammographic evaluation, decreasing the recall rate. Limitations: Interpretation time, cost and Breast neoplasms low sensitivity to calcifications.Conclusions : Breast Tomosynthesis is a new complementary tool of digital mammography which has showed a positive impact in breast cancer diagnosis in comparison to the conventional 2D mammography. Decreased recall rates could have PALABRAS CLAVE (DeCS) significant impact in costs, early detection and a decrease in anxiety. Mamografía Tomografía Diagnóstico RESUMEN Neoplasias de la mama Objetivo: Evaluar el estado del arte de la tomosíntesis como herramienta complementaria de la mamografía digital directa. Metodología: Se realizó una búsqueda sistemática de la literatura de artículos originales y de revisión a través de PubMed. Se revisaron los aspectos más importantes en cuanto a utilidad y limitaciones de la tomosíntesis en las imágenes de mama. -
HISTORY Nuclear Medicine Begins with a Boa Constrictor
HISTORY Nuclear Medicine Begins with a Boa Constrictor Marshal! Brucer J Nucl Med 19: 581-598, 1978 In the beginning, a boa constrictor defecated in and then analyzed the insoluble precipitate. Just as London and the subsequent development of nuclear he suspected, it was almost pure (90.16%) uric medicine was inevitable. It took a little time, but the acid. As a thorough scientist he also determined the 139-yr chain of cause and effect that followed was "proportional number" of 37.5 for urea. ("Propor inexorable (7). tional" or "equivalent" weight was the current termi One June week in 1815 an exotic animal exhibi nology for what we now call "atomic weight.") This tion was held on the Strand in London. A young 37.5 would be used by Friedrich Woehler in his "animal chemist" named William Prout (we would famous 1828 paper on the synthesis of urea. Thus now call him a clinical pathologist) attended this Prout, already the father of clinical pathology, be scientific event of the year. While he was viewing a came the grandfather of organic chemistry. boa constrictor recently captured in South America, [Prout was also the first man to use iodine (2 yr the animal defecated and Prout was amazed by what after its discovery in 1814) in the treatment of thy he saw. The physiological incident was common roid goiter. He considered his greatest success the place, but he was the only person alive who could discovery of muriatic acid, inorganic HC1, in human recognize the material. Just a year earlier he had gastric juice. -
The Supply of Medical Isotopes
The Supply of Medical Isotopes AN ECONOMIC DIAGNOSIS AND POSSIBLE SOLUTIONS The Supply of Medical Isotopes AN ECONOMIC DIAGNOSIS AND POSSIBLE SOLUTIONS The Supply of Medical Isotopes AN ECONOMIC DIAGNOSIS AND POSSIBLE SOLUTIONS This work is published under the responsibility of the Secretary-General of the OECD. The opinions expressed and arguments employed herein do not necessarily reflect the official views of OECD member countries. This document, as well as any data and any map included herein, are without prejudice to the status of or sovereignty over any territory, to the delimitation of international frontiers and boundaries and to the name of any territory, city or area. Please cite this publication as: OECD/NEA (2019), The Supply of Medical Isotopes: An Economic Diagnosis and Possible Solutions, OECD Publishing, Paris, https://doi.org/10.1787/9b326195-en. ISBN 978-92-64-94550-0 (print) ISBN 978-92-64-62509-9 (pdf) The statistical data for Israel are supplied by and under the responsibility of the relevant Israeli authorities. The use of such data by the OECD is without prejudice to the status of the Golan Heights, East Jerusalem and Israeli settlements in the West Bank under the terms of international law. Photo credits: Cover © Yok_onepiece/Shutterstock.com. Corrigenda to OECD publications may be found on line at: www.oecd.org/about/publishing/corrigenda.htm. © OECD 2019 You can copy, download or print OECD content for your own use, and you can include excerpts from OECD publications, databases and multimedia products in your own documents, presentations, blogs, websites and teaching materials, provided that suitable acknowledgement of OECD as source and copyright owner is given. -
Radioactive Waste
Radioactive Waste 07/05/2011 1 Regulations 2 Regulations 1. Nuclear Regulatory Commission (NRC) 10 CFR 20 Subpart K. Various approved options for radioactive waste disposal. (See also Appendix F) 10 CFR 35.92. Decay in storage of medically used byproduct material. 10 CFR 60. Disposal of high-level wastes in geologic repositories. 10 CFR 61. Shallow land disposal of low level waste. 10 CFR 62. Criteria and procedures for emergency access to non-Federal and regional low-level waste disposal facilities. 10 CFR 63. Disposal of high-level rad waste at Yucca Mountain, NV 10 CFR 71 Subpart H. Quality assurance for waste packaging and transportation. 10 CFR 72. High level waste storage at an MRS 3 Regulations 2. Department of Energy (DOE) DOE Order 435.1 Radioactive Waste Management. General Requirements regarding radioactive waste. 10 CFR 960. General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. Site selection guidelines for a waste repository. The following are not regulations but they provide guidance regarding the implementation of DOE Order 435.1: DOE Manual 435.1-1. Radioactive Waste Management Manual. Describes the requirements and establishes specific responsibilities for implementing DOE O 435.1. DOE Guide 435.1-1. Suggestions and acceptable ways of implementing DOE M 435.1-1 4 Regulations 3. Environmental Protection Agency 40 CFR 191. Environmental Standards for the Disposal of Spent Nuclear Fuel, High-level and Transuranic Radioactive Wastes. Protection for the public over the next 10,000 years from the disposal of high-level and transuranic wastes. 4. Department of Transportation 49 CFR Parts 171 to 177. -
Fission-Produced 99Mo Without a Nuclear Reactor
BRIEF COMMUNICATIONS Fission-Produced 99Mo Without a Nuclear Reactor Amanda J. Youker, Sergey D. Chemerisov, Peter Tkac, Michael Kalensky, Thad A. Heltemes, David A. Rotsch, George F. Vandegrift, John F. Krebs, Vakho Makarashvili, and Dominique C. Stepinski Argonne National Laboratory, Nuclear Engineering Division, Argonne, Illinois halted in the past due to inclement weather, natural phenomena, 99Mo, the parent of the widely used medical isotope 99mTc, is cur- flight delays, and terrorist threats (6). rently produced by irradiation of enriched uranium in nuclear reac- The predominant global 99Mo production route is irradiation of tors. The supply of this isotope is encumbered by the aging of these highly enriched uranium (HEU, $20% 235U) solid targets in nuclear reactors and concerns about international transportation and nu- reactors fueled by uranium (2). Other potential 99Mo production Methods: clear proliferation. We report results for the production paths include (n,g)98Mo and (g,n)100Mo; however, both routes re- of 99Mo from the accelerator-driven subcritical fission of an aqueous quire enriched molybdenum material and produce low-specific- solution containing low enriched uranium. The predominately fast 99 neutrons generated by impinging high-energy electrons onto a tan- activity Mo, which cannot be loaded directly on a commercial 99m talum convertor are moderated to thermal energies to increase fission Tc generator. The U.S. National Nuclear Security Administra- processes. The separation, recovery, and purification of 99Mo were tion implements the long-standing U.S. policy to minimize and demonstrated using a recycled uranyl sulfate solution. Conclusion: eliminate HEU in civilian applications by working to convert re- The 99Mo yield and purity were found to be unaffected by reuse of the search reactors and medical isotope production facilities to low previously irradiated and processed uranyl sulfate solution. -
Radiopharmacy Introduction
Radiopharmacy Introduction This Chapter is an amended version of the Good Radiopharmacy Practice Position Paper (GRPP), prepared as a policy document by the SIG Radiopharmacy and Nuclear Medicine of the Netherlands Association of Hospital Pharmacists (NVZA). Introduction In practice, Healthcare Inspectorate (IGZ) inspections in hospitals identify issues during the preparation and reconstitution and/ or aseptic handling (RAH) of radiopharmaceuticals in relation to the interpretation and application of the Dutch Good Manufacturing Practice for hospitals (GMP-z) guidelines. This Chapter aims to provide an unambiguous framework to ensure that there is no doubt about the guidelines and circumstances that apply to every situation. Principles, legislation and regulations In the Netherlands, around 65 hospitals have a Nuclear Medicine Department. More than 50% of these Departments are currently supplied by one of the three radiopharmacies of GE Healthcare. In the other hospitals, the radiopharmaceuticals are prepared by the Radiopharmacy, as well known as the “hot lab”. As this generally concerns centers with a major Nuclear Medicine Department, it can be said that the largest volume of radiopharmaceuticals is produced in the hospitals themselves. Radionuclides and radiopharmaceuticals are also purchased ready-made and are prepared for administration by the hot lab. Radiopharmaceuticals are ordinary pharmacy preparations, but differ from other prepared medicines due to their small-scale preparation (always prepared shortly before for administration (PFA)) on a patients name, sometimes preceded by a labelling step with a radionuclide generated in-house or not), their short shelf-life (due to radioactive decay) and the low pharmacological doses that are generally used. The radiation dose for the patient is generally low, as most radiopharmaceuticals are used for diagnostic purposes. -
Thermography) for Population Screening and Diagnostic Testing of Breast Cancer
NZHTA TECH BRIEF SERIES July 2004 Volume 3 Number 3 Review of the effectiveness of infrared thermal imaging (thermography) for population screening and diagnostic testing of breast cancer Jane Kerr New Zealand Health Technology Assessment Department of Public Health and General Practice Christchurch School of Medicine Christchurch, NZ. Division of Health Sciences, University of Otago NEW ZEALAND HEALTH TECHNOLOGY ASSESSMENT (NZHTA) Department of Public Health and General Practice Christchurch School of Medicine and Health Sciences Christchurch, New Zealand Review of the effectiveness of infrared thermal imaging (thermography) for population screening and diagnostic testing of breast cancer Jane Kerr NZHTA TECH BRIEF SERIES July 2004 Volume 3 Number 3 This report should be referenced as follows: Kerr, J. Review of the effectiveness of infrared thermal imaging (thermography) for population screening and diagnostic testing of breast cancer. NZHTA Tech Brief Series 2004; 3(3) Titles in this Series can be found on the NZHTA website: http://nzhta.chmeds.ac.nz/thermography_breastcancer.pdf 2004 New Zealand Health Technology Assessment (NZHTA) ISBN 1-877235-64-4 ISSN 1175-7884 i ACKNOWLEDGEMENTS This Tech Brief was commissioned by the National Screening Unit of the New Zealand Ministry of Health. The report was prepared by Dr Jane Kerr (Research Fellow) who selected and critically appraised the evidence. The research protocol for this report was developed by Ms Marita Broadstock (Research Fellow). The literature search strategy was developed and undertaken by Mrs Susan Bidwell (Information Specialist Manager). Mrs Ally Reid (Administrative Secretary) provided document formatting. Internal peer review was provided by Dr Robert Weir (Senior Research Fellow), Dr Ray Kirk (Director) and Ms Broadstock. -
Learn More About X-Rays, CT Scans and Mris (Pdf)
What is the difference between X-Rays, CT Scans, and MRIs? X-Rays are a form of electromagnetic radiation, like light. They are less energetic than gamma rays, and more energetic than ultraviolet light. Because they pass easily through soft tissue, like organs and muscles, but not so easily through hard tissue like bones and teeth, we are most familiar with them being used to look at skeletal structures. Sometimes a person ingests or has injected an X-ray opaque fluid that will fill a space of interest for X-ray imaging. This is called an angiogram. A nuclear scan uses an injected gamma ray emitting substance that accumulates in the organ of interest and a special camera records the gamma rays. A CT Scan is usually a series of X-rays taken from different directions that are then assembled into a three dimensional model of the subject in a computer. CT stands for computed tomography, and tomography means a picture of a slice. Where an X-ray may show edges of soft tissues all stacked on top of each other, the computer in a CT scan can figure out how those edges relate to each other in depth, and so the image has much more soft tissue usability. Another kind of CT scan uses positrons. I have to mention this because positrons are antimatter electrons (Yes, antimatter does exist and it is useful!) In Positon Emission Tomography (PET) a positron emitting radionuclide (radioactive material) is attached to a metabolically useful molecule. This is introduced to the tissue, and as emitted positrons decompose they emit gamma rays which can be traced by the machine and computer back to their points of origin, and an image is formed.