ISSN:2471-061X Peter A. Clark, S.J (2019) J Addict Depend 5(1): 1-18 DOI: 10.15436/2471-061X.19.2638 Journal of Volume 5 | Issue 1 OPEN ACCESS ResearchAddiction Article and Dependence Is Medical Marijuana a Viable Option for Opioid Replacement Therapy? Peter A. Clark, S.J.*, Gabriella Mamo*, Samuel Schadt, Sonul Gulati, Arun Minupuri, John Dubensky, Archen Krupadev, Rushabh Shah, Shengnan Zheng, Jesus Salas Noain, Cameron Fick, Olivia Nguyen, Patrick Laird, Rishi Gulati, Michael Fontana, Priscilla Rodriguez, Graham Clifford, Sean McDermott, Haley Patrick, Justin Stout, Jordan Davis Institute of Clinical Bioethics, Saint Joseph’s University, 5600 City Avenue, Philadelphia, Pennsylvania, USA *Corresponding author: Peter A. Clark S.J, Director, Institute of Clinical Bioethics, Saint Joseph’s University, 5600 City Avenue, Philadel- phia, Pennsylvania, USA 19131, Tel: 610-660-3425, E-mail:
[email protected] Gabriella Mamo, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, Pennsylvania, USA 19131; E-mail: gm270930@ pcom.edu Abstract The opioid epidemic has become one of the most serious health crises in the United States. Current replacement ther- apies for opioid use disorder, such as methadone, buprenorphine, and naltrexone, are not sufficient enough to treat recovering opioid users due to disadvantages such as inadequate availability and potential side effects. As a result, new alternatives to these drugs must be addressed. This article addresses the permissibility of using medical marijuana as a potential replacement therapy for Opioid Use Disorder and opioid withdrawal from the pharmacological, medical, legal, and ethical perspectives. Pharmacologically, current replacement therapies are used to decrease the symptoms of with- drawal and lower the risk of overdose but have several limitations.