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Mater Hospital Research Report 2017

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Mater Hospital Research Report 2017 RESEARCH REPORT 2018 Mater Misericoridae University Hospital Working in partnership with 2 Page 3 Contents About Us............................................................................................................................................................................. 4 Our Research at a Glance ................................................................................................................................................... 5 CEO Message ...................................................................................................................................................................... 6 Clinical Research Activity ................................................................................................................................................... 7 Oncology Research ............................................................................................................................................................. 9 HIV Molecular Research Group ........................................................................................................................................ 10 Stroke Clinical Trials ......................................................................................................................................................... 12 Supporting Research ........................................................................................................................................................ 18 Publications ...................................................................................................................................................................... 21 3 Page 4 About Us Mater Misericoriae University Hospital The Mater Misericordiae University Hospital prioritises research that translates rapidly into patient The Mater Misericordiae University Hospital is a major benefits. Through our partnerships with our academic academic level 4 teaching hospital based in Dublin's partner University College Dublin (UCD) and other north inner city. The hospital was opened in 1861 by academic institutions, we have a strong track record the Sisters of Mercy and provides a range of frontline in producing high quality research that delivers real and specialist services on a local, regional and national and meaningful results to patients. level. Our strong academic partnership with UCD is reflected Education, training and research have always been at in significant impact UCD's Clinical Research Centre the core of the Mater. The hospital is committed to (CRC) has on research on the campus. The CRC was providing excellence in healthcare for all patients and opened at the hospital in 2006 and forms part of a in order to achieve this we recognise the importance research network across the Mater Hospital, St in providing support to our current and future staff to Vincent's University Hospital and University College learn, grow and innovate. Dublin. Ireland East Hospital Group The Mater is part of the Ireland East Hospital Group (IEHG) which is the largest and most diverse of the seven hospital groups. The IEHG consists of 11 hospitals and our academic partner University College Dublin and serves a catchment area of over 1.2 million people. The development of the IEHG presents a unique opportunity within the Irish healthcare system to build on the excellence of our hospitals, combine with the innovation, research and educational excellence provided by UCD to deliver consistent high quality safe healthcare outcomes and the world class healthcare our patients deserve. The Ireland East Hospital Group is evolving into an Academic Health Sciences Centre, which is embedding research and education into our care delivery model. This will enhance our ability to deliver evidence base excellence in care delivery, education, training, research and improve healthcare outcomes for our patients. The hospitals within the Ireland East Hospital Group are Mater Misericordiae University Hospital Wexford General Hospital St Michael’s Hospital, Dun Laoghaire St Vincent’s University Hospital Our Lady’s Hospital, Navan Cappagh National Orthopaedic Hospital Midland Regional Hospital Mullingar St Columcille’s Hospital Royal Victoria Eye and Ear Hospital St Luke’s General Hospital, Kilkenny National Maternity4 Hospital Page 5 Our Research at a Glance 101 Research Projects 15 Oncology Studies There were 101 research projects Oncology was the largest research area in undertaken in the Mater Hospital in 2017 2017, with 15 studies COMMITTED TO IMPROVING HEALTH THROUGH RESEARCH 46 Clinical Drug/Device Trials 237 Publications There were 46 clinical drug or device trials There were 235 papers published in underway during the course of the year. medical and scientific journals in 2017 5 Page 6 CEO Message A strong and vibrant health and medical research Well-designed clinical trials provide the necessary component is crucial for improving our health and evidence to demonste if a treatment is both effective quality of life. The Mater Misericordiae University and safe. We offer clinical trials as part of our Hospital is dedicated to advancing the translation of commitment to bringing our patients new and research into improved patient outcomes. We do this innovative treatments and all trial protocols are by encouraging healthcare innovation and approved by our Research Ethics Committee. experiementation and taking a leadership role in Additionally, the local knowledge, skills and expertise clinical trials. 2018 will bring further exciting changes of our nursing, medical and pharmacy workforce is on the Mater campus, including the the evolution of enhanced through this work. the Ireland East Hospital Group and UCD into an Academic Health Sciences Centre, which will enable We are privileged at the Mater Hospital to have an our campus will grow as an outstanding centre of engaged and supportive clinical workforce to advance research excellence. medical research. Of course, and perhaps most importantly, advances in healthcare require patients Our inaugural Research Annual Report reveals a year and volunteers with the courage to embark on a of significant scientific achievements. These journey which has an informed, but often unclear, achievements reflect our commitment to a highly destination. I would like to sincerely thank all of the collaborative, multidisciplinary culture that we believe patients, volunteers and carers without which much will continue to produce life-changing innovations to of our research would not be possible. benefit our patients and their families for years to come. The pace of scientific research is continually accelerating and the rich partnership between the Mater Misericordiae University Hospital and University College Dublin is an impressive example of a fruitful and long-lasting relationship. Our inclusive and innovative community is the facilitator that inspires our researchers to develop and function at Gordon Dunne, Chief Executive their highest level and is what makes the Mater campus exceptional. 6 Page 7 Clinical Research Activity Across the hospital, 101 studies were ongoing over NUMBER OF CLINICAL TRIALS BY PHASE the past year. Of those studies, 43 were clinical trials, 38 observational and 20 comprised of translational, biobanking, registries or device studies. It is important to note that a significant proportion of the studies are academic initiated; with 52% of them academic-initiated and 48% industry-sponsored. 5 30 5 PHASE 1 PHASE 2 PHASE 3 PHASE 4 Within the clinical trials area, the primary focus is on mid-phase trials 33 phase 3 Studies NUMBER OF STUDIES BY TYPE 5 phase 2 Studies 5 phase 4 Studies Clinical Trial 43 During 2017 a feasibility review was carried out on the Observational 38 development of a Phase 1 Clinical Trials Unit on the Mater Hospital and St Vincent’s Hospital sites. Lab - BioBank Trial 9 The review recommended the development of an Early Phase Clinical Trials Unit which will provide Registry Trial 6 further options for patients. Device Trial 3 Other Trial 2 7 Page 8 NUMBER OF STUDIES BY TYPE STUDIES BY ORIGIN Oncology 15 Industry 52% Gastroenterology 14 Infectious Diseases 13 Cardiology 9 Neurology 9 Academic 48% Anaesthesiology 8 Rheumatology 7 Ophthalmology 6 Nephrology 6 Urology 4 Respiratory 3 Pathology 2 ICU 1 Endocrinology 1 Metabolic 1 8 Page 9 Oncology Research Clinical trials in oncology are an integral part of the care pathway and offer treatment options for patients. The CTRU is an integral part of the service and delivery of patient care across the Mater campus. The Clinical Trials Research Unit (CTRU) at the Mater consultant oncologists and four consultant campus was established in 2000 under the direction haematologists. There is an additional Consultant of Prof John McCaffrey. The Mater Campus medical oncologist at the Mater Private Hospital. incorporates Mater Misericordiae University Hospital The team have a high study accrual rates across a and Mater Private Hospital. Cavan General Hospital is wide variety of tumour types most notably in Breast, a satellite Oncology/Haematology Centre of the Mater GU, Lung, Lymphoma, Gynaecological malignancies, Misericordiae service. Gastro-intestinal and Melanoma. There is a clear process in place which accepts patients for Clinical CANCER STUDIES BY DISEASE SPECIFIC SUB GROUP Trials from other regional hospitals and a well- established relationship with international collaborative research groups and translational Genito-urinary
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