Statistical Inference of Truncated Normal Distribution Based on the Generalized Progressive Hybrid Censoring
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
A Simple Censored Median Regression Estimator
Statistica Sinica 16(2006), 1043-1058 A SIMPLE CENSORED MEDIAN REGRESSION ESTIMATOR Lingzhi Zhou The Hong Kong University of Science and Technology Abstract: Ying, Jung and Wei (1995) proposed an estimation procedure for the censored median regression model that regresses the median of the survival time, or its transform, on the covariates. The procedure requires solving complicated nonlinear equations and thus can be very difficult to implement in practice, es- pecially when there are multiple covariates. Moreover, the asymptotic covariance matrix of the estimator involves the density of the errors that cannot be esti- mated reliably. In this paper, we propose a new estimator for the censored median regression model. Our estimation procedure involves solving some convex min- imization problems and can be easily implemented through linear programming (Koenker and D'Orey (1987)). In addition, a resampling method is presented for estimating the covariance matrix of the new estimator. Numerical studies indi- cate the superiority of the finite sample performance of our estimator over that in Ying, Jung and Wei (1995). Key words and phrases: Censoring, convexity, LAD, resampling. 1. Introduction The accelerated failure time (AFT) model, which relates the logarithm of the survival time to covariates, is an attractive alternative to the popular Cox (1972) proportional hazards model due to its ease of interpretation. The model assumes that the failure time T , or some monotonic transformation of it, is linearly related to the covariate vector Z 0 Ti = β0Zi + "i; i = 1; : : : ; n: (1.1) Under censoring, we only observe Yi = min(Ti; Ci), where Ci are censoring times, and Ti and Ci are independent conditional on Zi. -
HST 190: Introduction to Biostatistics
HST 190: Introduction to Biostatistics Lecture 8: Analysis of time-to-event data 1 HST 190: Intro to Biostatistics • Survival analysis is studied on its own because survival data has features that distinguish it from other types of data. • Nonetheless, our tour of survival analysis will visit all of the topics we have learned so far: § Estimation § One-sample inference § Two-sample inference § Regression 2 HST 190: Intro to Biostatistics Survival analysis • Survival analysis is the area of statistics that deals with time-to- event data. • Despite the name, “survival” analysis isn’t only for analyzing time until death. § It deals with any situation where the quantity of interest is amount of time until study subject experiences some relevant endpoint. • The terms “failure” and “event” are used interchangeably for the endpoint of interest • For example, say researchers record time from diagnosis to death (in months) for a sample of patients diagnosed with laryngeal cancer. § How would you summarize the survival of laryngeal cancer patients? 3 HST 190: Intro to Biostatistics • A simple idea is to report the mean or median survival time § However, sample mean is not robust to outliers, meaning small increases the mean don’t show if everyone lived a little bit longer or whether a few people lived a lot longer. § The median is also just a single summary measure. • If considering your own prognosis, you’d want to know more! • Another simple idea: report survival rate at � years § How to choose cutoff time �? § Also, just a single summary measure—graphs show same 5-year rate 4 HST 190: Intro to Biostatistics • Summary measures such as means and proportions are highly useful for concisely describing data. -
Linear Regression with Type I Interval- and Left-Censored Response Data
Environmental and Ecological Statistics 10, 221±230, 2003 Linear regression with Type I interval- and left-censored response data MARY LOU THOMPSON1,2 and KERRIE P. NELSON2 1Department of Biostatistics, Box 357232, University of Washington, Seattle, WA98195, USA 2National Research Center for Statistics and the Environment, University of Washington E-mail: [email protected] Received April2001; Revised November 2001 Laboratory analyses in a variety of contexts may result in left- and interval-censored measurements. We develop and evaluate a maximum likelihood approach to linear regression analysis in this setting and compare this approach to commonly used simple substitution methods. We explore via simulation the impact on bias and power of censoring fraction and sample size in a range of settings. The maximum likelihood approach represents only a moderate increase in power, but we show that the bias in substitution estimates may be substantial. Keywords: environmental data, laboratory analysis, maximum likelihood 1352-8505 # 2003 Kluwer Academic Publishers 1. Introduction The statisticalpractices of chemists are designed to protect against mis-identifying a sample compound and falsely reporting a detectable concentration. In environmental assessment, trace amounts of contaminants of concern are thus often reported by the laboratory as ``non-detects'' or ``trace'', in which case the data may be left- and interval- censored respectively. Samples below the ``non-detect'' threshold have contaminant levels which are regarded as being below the limits of detection and ``trace'' samples have levels that are above the limit of detection, but below the quanti®able limit. The type of censoring encountered in this setting is called Type I censoring: the censoring thresholds (``non-detect'' or ``trace'') are ®xed and the number of censored observations is random. -
Statistical Methods for Censored and Missing Data in Survival and Longitudinal Analysis
University of Pennsylvania ScholarlyCommons Publicly Accessible Penn Dissertations 2019 Statistical Methods For Censored And Missing Data In Survival And Longitudinal Analysis Leah Helene Suttner University of Pennsylvania, [email protected] Follow this and additional works at: https://repository.upenn.edu/edissertations Part of the Biostatistics Commons Recommended Citation Suttner, Leah Helene, "Statistical Methods For Censored And Missing Data In Survival And Longitudinal Analysis" (2019). Publicly Accessible Penn Dissertations. 3520. https://repository.upenn.edu/edissertations/3520 This paper is posted at ScholarlyCommons. https://repository.upenn.edu/edissertations/3520 For more information, please contact [email protected]. Statistical Methods For Censored And Missing Data In Survival And Longitudinal Analysis Abstract Missing or incomplete data is a nearly ubiquitous problem in biomedical research studies. If the incomplete data are not appropriately addressed, it can lead to biased, inefficient estimation that can impact the conclusions of the study. Many methods for dealing with missing or incomplete data rely on parametric assumptions that can be difficult or impossibleo t verify. Here we propose semiparametric and nonparametric methods to deal with data in longitudinal studies that are missing or incomplete by design of the study. We apply these methods to data from Parkinson's disease dementia studies. First, we propose a quantitative procedure for designing appropriate follow-up schedules in time-to-event studies to address the problem of interval-censored data at the study design stage. We propose a method for generating proportional hazards data with an unadjusted survival similar to that of historical data. Using this data generation process we conduct simulations to evaluate the bias in estimating hazard ratios using Cox regression models under various follow-up schedules to guide the selection of follow-up frequency. -
Common Misunderstandings of Survival Time Analysis
Common Misunderstandings of Survival Time Analysis Milensu Shanyinde Centre for Statistics in Medicine University of Oxford 2nd April 2012 C S M Outline . Introduction . Essential features of the Kaplan-Meier survival curves . Median survival times . Median follow-up times . Forest plots to present outcomes by subgroups C S M Introduction . Survival data is common in cancer clinical trials . Survival analysis methods are necessary for such data . Primary endpoints are considered to be time until an event of interest occurs . Some evidence to indicate inconsistencies or insufficient information in presenting survival data . Poor presentation could lead to misinterpretation of the data C S M 3 . Paper by DG Altman et al (1995) . Systematic review of appropriateness and presentation of survival analyses in clinical oncology journals . Assessed; - Description of data analysed (length and quality of follow-up) - Graphical presentation C S M 4 . Cohort sample size 132, paper publishing survival analysis . Results; - 48% did not include summary of follow-up time - Median follow-up was frequently presented (58%) but method used to compute it was rarely specified (31%) Graphical presentation; - 95% used the K-M method to present survival curves - Censored observations were rarely marked (29%) - Number at risk presented (8%) C S M 5 . Paper by S Mathoulin-Pelissier et al (2008) . Systematic review of RCTs, evaluating the reporting of time to event end points in cancer trials . Assessed the reporting of; - Number of events and censoring information - Number of patients at risk - Effect size by median survival time or Hazard ratio - Summarising Follow-up C S M 6 . Cohort sample size 125 . -
1.2 Examples of Descriptive Statistics in Statistics, a Summary Statistic Is a Single Numerical Measure of an At- Tribute of a Sample
Arkansas Tech University MATH 3513: Applied Statistics I Dr. Marcel B. Finan 1.2 Examples of Descriptive Statistics In Statistics, a summary statistic is a single numerical measure of an at- tribute of a sample. In this section we discuss commonly used summary statistics. Sample Mean The sample mean (also known as average or arithmetic mean) is a mea- sure of the \center" of the data. Suppose that a sample consists of the data values x1; x2; ··· ; xn: Then the sample mean is given by the formula n x1 + x2 + ··· + xn 1 X x = = x : n n i i=1 Example 1.2.1 A random sample of 10 ATU students reported missing school 7, 6, 8, 4, 2, 7, 6, 7, 6, 5 days. Find the sample mean. Solution. The sample mean is 7+6+8+4+2+7+6+7+6+5 x = = 5:8 days 10 The Sample Variance and Standard Deviation The Standard deviation is a measure of the spread of the data around the sample mean. When the spread of data is large we expect most of the sample values to be far from the mean and when the spread is small we expect most of the sample values to be close to the mean. Suppose that a sample consists of the data values x1; x2; ··· ; xn: One way of measuring how these values are spread around the mean is to compute the deviations of these values from the mean, i.e., x1 − x; x2 − x; ··· ; xn − x and then take their average, i.e., find how far, on average, is each data value from the mean. -
CPS397-P1-S.Pdf
Model selection curves for survival analysis with accelerated failure time models Karami, J. H.*, Luo, K., Fung, T. Macquarie University, Sydney, Australia – [email protected], [email protected], [email protected] Abstract Many model selection processes involve minimizing a loss function of the data over a set of models. A recent introduced approach is model selection curves, in which the selection criterion is expressed as a function of penalty multiplier in a linear (mixed) model or generalized linear model. In this article, we have adopted the model selection curves for accelerated failure time (AFT) models of survival data. In our simulation study, it was found that for data with small sample size and high proportion of censoring, the model selection curves approach outperformed the traditional model selection criteria, Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC). In other situations with respect to sample size and proportion of censoring, the model selection curves correctly identify the true model whether it is a full or reduced model. Moreover, through bootstrapping, it was shown that the model selection curves can be used to enhance the model selection process in AFT models. Keywords: log-likelihood function; penalty function; penalty multiplier; survival data. 1. Introduction Many model selection strategies are based on minimizing 푙표푠푠 + 푝푒푛푎푙푡푦 over a set of models. The penalty term usually consists of a penalty multiplier 휆 and a penalty function 푓푛(푝훼), where 푝훼 is the number of parameters in model 훼 and 푛 is the sample size. For a fixed penalty function, say 푓푛(푝훼) = 푝훼, if we restrict ourselves to a single value of 휆, we get a specififc model selection criteria. -
Bayesian Analysis of Survival Data with Missing Censoring Indicators and Simulation of Interval Censored Data Veronica Bunn
Florida State University Libraries Electronic Theses, Treatises and Dissertations The Graduate School 2018 Bayesian Analysis of Survival Data with Missing Censoring Indicators and Simulation of Interval Censored Data Veronica Bunn Follow this and additional works at the DigiNole: FSU's Digital Repository. For more information, please contact [email protected] FLORIDA STATE UNIVERSITY COLLEGE OF ARTS AND SCIENCES BAYESIAN ANALYSIS OF SURVIVAL DATA WITH MISSING CENSORING INDICATORS AND SIMULATION OF INTERVAL CENSORED DATA By VERONICA BUNN A Dissertation submitted to the Department of Statistics in partial fulfillment of the requirements for the degree of Doctor of Philosophy 2018 Copyright c 2018 Veronica Bunn. All Rights Reserved. Veronica Bunn defended this dissertation on July 10, 2018. The members of the supervisory committee were: Debajyoti Sinha Professor Co-Directing Dissertation Naomi Brownstein Professor Co-Directing Dissertation Richard Nowakowski University Representative Elizabeth Slate Committee Member Antonio Linero Committee Member The Graduate School has verified and approved the above-named committee members, and certifies that the dissertation has been approved in accordance with university requirements. ii To my sister, who has done more for me than she will ever know. iii ACKNOWLEDGMENTS Special thanks are due to my advisors, Dr. Debajyoti Sinha and Dr. Naomi Brownstein, for guiding me through the research process. Additional thanks to my committee members Dr. Elizabeth Slate, Dr. Antonio Linero, and Dr. Richard Nowakowski for their time and valuable feedback. I would also like to thank my peers in the Department of Statistics at Florida State University for their camaraderie and lunch discussions. Lastly, I'd like to thank Rumy for his unwavering belief and support in my goals { here's to us, and the next chapter in our lives. -
Censored Regression Models in R Using the Censreg Package
Estimating Censored Regression Models in R using the censReg Package Arne Henningsen University of Copenhagen Abstract We demonstrate how censored regression models (including standard Tobit models) can be estimated in R using the add-on package censReg. This package provides not only the usual maximum likelihood (ML) procedure for cross-sectional data but also the random-effects maximum likelihood procedure for panel data using Gauss-Hermite quadrature. Keywords: censored regression, Tobit, econometrics, R. 1. Introduction In many statistical analyses of individual data, the dependent variable is censored, e.g. the number of hours worked, the number of extramarital affairs, the number of arrests after release from prison, purchases of durable goods, or expenditures on various commodity groups (Greene 2008, p. 869). If the dependent variable is censored (e.g. zero in the above examples) for a significant fraction of the observations, parameter estimates obtained by conventional regression methods (e.g. OLS) are biased. Consistent estimates can be obtained by the method proposed by Tobin(1958). This approach is usually called \Tobit" model and is a special case of the more general censored regression model. This paper briefly explains the censored regression model, describes function censReg of the R package censReg, and demonstrates how this function can be used to estimate censored regression models. There are also some other functions for estimating censored regression models available in R. For instance function tobit from the AER package (Kleiber and Zeileis 2008, 2009) and function cenmle from the NADA package are front ends to the survreg function from the survival package. Function tobit from the VGAM package estimates the censored regression model by using its own maximum likelihood routine. -
Chapter 4 Truncated Distributions
Chapter 4 Truncated Distributions This chapter presents a simulation study of several of the confidence intervals first presented in Chapter 2. Theorem 2.2 on p. 50 shows that the (α, β) trimmed mean Tn is estimating a parameter μT with an asymptotic variance 2 2 equal to σW /(β−α) . The first five sections of this chapter provide the theory needed to compare the different confidence intervals. Many of these results will also be useful for comparing multiple linear regression estimators. Mixture distributions are often used as outlier models. The following two definitions and proposition are useful for finding the mean and variance of a mixture distribution. Parts a) and b) of Proposition 4.1 below show that the definition of expectation given in Definition 4.2 is the same as the usual definition for expectation if Y is a discrete or continuous random variable. Definition 4.1. The distribution of a random variable Y is a mixture distribution if the cdf of Y has the form k FY (y)= αiFWi (y) (4.1) i=1 <α < , k α ,k≥ , F y where 0 i 1 i=1 i =1 2 and Wi ( ) is the cdf of a continuous or discrete random variable Wi, i =1, ..., k. Definition 4.2. Let Y be a random variable with cdf F (y). Let h be a function such that the expected value Eh(Y )=E[h(Y )] exists. Then ∞ E[h(Y )] = h(y)dF (y). (4.2) −∞ 104 Proposition 4.1. a) If Y is a discrete random variable that has a pmf f(y) with support Y,then ∞ Eh(Y )= h(y)dF (y)= h(y)f(y). -
Censoring and Truncation
Censoring and Truncation Time-to-event data present themselves in different ways which create special problems in analyzing such data. One peculiar feature, often present in time-to-event data, is known as censoring, which, broadly speaking, occurs when some lifetimes are known to have occurred only within certain intervals. The remainder of the lifetimes are known ex- actly. There are various categories of censoring, such as right censoring, left censoring, and interval censoring. Right censoring will be discussed in section 3.2. Left or interval censoring will be discussed in section 3.3. To deal adequately with censoring in the analysis, we must consider the design which was employed to obtain the survival data. There are several types of censoring schemes within both left and right censoring. Each type will lead to a different likelihood function which will be the basis for the inference. As we shall see in section 3.5, though the likeli- hood function is unique for each type of censoring, there is a common approach to be used in constructing it. A second feature which may be present in some survival studies is that of truncation, discussed in section 3.4. Left truncation occurs when subjects enter a study at a particular age (not necessarily the origin for the event of interest) and are followed from this delayed entry time until the event occurs or until the subject is censored. Right truncation 64 Chapter 3 Censoring and Truncation - 3.2 Right Censoring 65 occurs when only individuals who have experienced the event of in- her event time is censored at C,. -
An Approach to Understand Median Follow-Up by the Reverse Kaplan
PharmaSUG 2019 – Paper ST-81 Let’s Flip: An Approach to Understand Median Follow-up by the Reverse Kaplan-Meier Estimator from a Statistical Programmer’s Perspective Nikita Sathish and Chia-Ling Ally Wu, Seattle Genetics, Inc., Bothell, WA ABSTRACT In time-to-event analysis, sufficient follow-up time to capture enough events is the key element to have adequate statistical power. Achieving an adequate follow-up time may depend on the severity and prognosis of the disease. The median follow-up is the median observation time to the event of interest, which is an indicator to see the length of follow-up. There are several methods to calculate median follow- up, and we have chosen to use the more robust and code-efficient reverse Kaplan-Meier (KM) estimator in our paper. Median follow-up is a less commonly presented descriptive statistic in reporting survival analysis result, which could pose some challenges to understand. This paper aims to provide the concept of median follow- up, the statistical interpretation of median follow-up both numerically and visually, and the SAS® LIFETEST procedure to delineate survival plots and compute survival function using the reverse KM estimator. We present a simple and robust approach of calculating median follow-up using the reverse Kaplan-Meier estimator by flipping the meaning of event and censor (Schemper and Smith, 1996), i.e., event becomes censor while censor becomes the endpoint. INTRODUCTION In oncology studies, we use a lot of time-to-event analysis, which is to assess the time up to the event of interest, like from treatment to death, disease relapse or progression.