RESEARCH FOR RECOVERY ACCELERATING PATHWAYS TO MENTAL HEALTH

BRAIN & BEHAVIOR RESEARCH FOUNDATION

2017 ANNUAL REPORT

Awarding research grants to develop improved treatments, cures, and methods of prevention for mental illness.

www.bbrfoundation.org 1 FROM DISCOVERY TO RECOVERY

Mission The & Behavior Research Foundation (BBRF) is committed to alleviating the suffering caused by mental illness by awarding grants that will lead to advances and breakthroughs in scientific research.

Vision To dramatically improve the lives of those living with mental illness and ultimately enable them to live full, happy, and productive lives.

100% of all donor contributions for research are invested in grants that lead to discoveries in understanding the causes and improving treatments for brain and behavior disorders in children and adults including , ADHD, anxiety, autism, bipolar disorder, borderline personality disorder, depression, eating disorders, OCD, PTSD, , and suicide prevention.

For 30 years we have awarded more than $380 million, to more than 4,500 carefully selected by our prestigious Scientific Council.

2 ANNUAL REPORT 2017 BBRF GRANTS SUPPORT THE MOST PROMISING IDEAS IN BRAIN RESEARCH.

We invest in:

Basic Research to understand what happens in the brain to cause mental illness

New Technologies to advance or create new ways of studying and understanding the brain

Diagnostic Tools And Early Intervention to recognize early signs of mental illness and begin treatment as early as possible

Next-Generation Therapies to reduce symptoms of mental illness and ultimately prevent and cure brain and behavior disorders

www.bbrfoundation.org 3 Table of Contents 06 Leadership Letter 08 Leading Research Achievements by Foundation Grantees 20 Our Scientific Council 22 Our Newest Scientific Council Members 28 Webinars 29 Getting the Word Out 30 2017 Research Grants 34 Grants by Illness 43 Foundation Events 53 Donors Research Partners Donor Listings Matching Gift Companies Honor Tributes Memorial Tributes Team Up for Research 81 2017 Financial Summary

4 ANNUAL REPORT 2017 BY THE NUMBERS SINCE 1987 As of une 2018

AWARDED TO SIENTISTS $380 MILLION

GRANTS The breadown o our grantees since 1987 4,282 Young Investigators 828 Independent Investigators 426 Distinguished Investigators 5,500 Table of Contents 06 Leadership Letter 08 Leading Research Achievements UNIVERSITIES EDIAL ENTERS OUNTRIES, INLUDING THE U.S. by Foundation Grantees 20 Our Scientific Council 22 Our Newest Scientific Council Members 28 Webinars 550 29 Getting the Word Out 35 30 2017 Research Grants 34 Grants by Illness 175 ATIVE SIENTIFI OUNIL EBERS AND 7 EERITUS EBERS 43 Foundation Events The all-volunteer Foundation Scienti c The group includes: Council is composed of leading experts 52 Members of the National Academy of Medicine 53 Donors across disciplines in brain & behavior 26 Chairs of & Departments Research Partners research who review grant applications 13 Members of the National Academy of and recommend the most promising ideas 4 Recipients of the National Medal of Donor Listings to fund. 2 Former Directors of the National Institute of Mental Health and the Director Matching Gift Companies 2 Winners Honor Tributes Memorial Tributes Team Up for Research 81 2017 Financial Summary

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www.bbrfoundation.org 5 Dear Brain & Behavior Research Foundation Supporters:

Since 1987, the Brain & Behavior Research Foundation has BBRF is Accelerating Discovery… invested in the future. We support innovative brain and behavior In Genetics, Molecular Biology, Brain Imaging, Early research today which will lead to new treatments, cures, and Interventions, and Rapid-Acting Medications methods of prevention. We are proud to present you with our 2017 Annual Report. The achievements of our grantees are rooted in fostering a researcher’s career in brain science. BBRF is Leading The World… In Charitable Funding of Research Grants for Mental Illness A survey of our grantees revealed that Foundation grants increased a researcher’s ability to secure additional grant support. BBRF The Brain & Behavior Research Foundation is the largest non- grants result in subsequent funding (both federal and private) governmental funder of mental health research grants in the world. and the more than $380 million in grants awarded to date has With our operating expenses covered by separate foundation resulted in more than $3.8 billion in additional brain research grants, 100 percent of every dollar donated for research is funding for these scientists. invested in research grants. A recent RAND analysis of the global mental health research Now, three decades since our inception, we have awarded funding landscape found that we are the top non-governmental more than: funder cited in published articles.

• $380 million, in more than 5,500 grants, to more than 4,500 Results from the investigations funded by our grants continue to researchers, from 550 institutions in 35 countries around define the leading edge of all research in the mental health field the world. and once again, this past year proved to be a year of advancement.

• $19 million in grants in 2017 divided between our 17 Distin- The research findings we report on pages 8-19 in this annual report guished Investigators, 80 Independent Investigators and 400 would not be possible without the extraordinary volunteer effort Young Investigators. and leadership of our Scientific Council. This prestigious group of scientists steers the Foundation’s grants selection process. We are The Brain & Behavior Research Foundation’s sustained commit- proud to report that 12 distinguished experts joined the Scientific ment to research over the past 30 years and its plan for progress Council this year, bringing our total number to 175. Our new in the years ahead is empowered by a remarkable collaboration members are highlighted on page 22. between our donors and the worldwide leaders in brain science. BBRF is Informing the Public… BBRF is Advancing Recovery… About the Research Progress Which We Support in the Through Our Research Grants Field of Mental Health

Funding the most promising and cutting-edge research is at the This past year the Foundation continued its longstanding com- core of our mission. Supporting young scientists’ careers and mitment to public education with its annual International Mental keeping them in the field of neuroscience is vital to finding cures for Health Research Symposium (highlighted on page 46), which mental illness. Communicating research results and sharing insights offered complimentary general admission to hear presentations is also vitally important to our mission. from the Foundation’s 2017 Outstanding Achievement Prizewin- ners and two exceptional Young Investigator Grantees, on topics The pathway to the future of scientific research and discovery is ranging from schizophrenia and addiction to childhood inter- a challenging and lengthy process, but we remain committed to ventions and the brain circuitry behind mood disorders. These funding “innovative and out of the box” ideas because it is this presentations are available online. cutting-edge research that will eventually result in new treatments and cures for brain and behavior disorders. The “Meet the ” webinar series had more than 5,800

6 ANNUAL REPORT 2017 attendees from more than 52 countries register to watch the In contributing to BBRF you are supporting both an impressive program and post event, the series received more than 22,000 history of achievements that have advanced science and are paving views of the 2017 webinars on our YouTube channel. These public the way forward to change what it means to live with a mental events combined with our private fundraising events, and our illness and open possibilities for more people to live full, happy, and ongoing communications continually disseminate grantee research productive lives. We thank you for your ongoing support to help us discoveries and share stories of hope and recovery. Information get closer to realizing this vision. is available 24/7 on our redesigned and continuously updated website, bbrfoundation.org, and on our social media channels Sincerely, which include Facebook, Twitter, Instagram, LinkedIn and YouTube.

The Foundation’s publication, Brain & Behavior Magazine, has a circulation of more than 19,000 and can also be found in the media section of our website under publications.

The Foundation produces the Emmy Award-nominated public television series Healthy Minds which aims to remove the stigma of mental illness, educate the public and offer a message of hope by Jeffrey Borenstein, M.D. shedding light on common psychiatric conditions through inspiring President & CEO personal stories and experts sharing cutting edge information on research and treatment. The goal of Healthy Minds is to inspire conversations about mental illness, and provide understandable information and resources for viewers.

BBRF and the Future

We are excited about recent technological advances that have made possible experiments that would have seemed Stephen A. Lieber like science fiction 30 years ago. The Foundation is proud of the Chair, Board of Directors accomplishments of the scientists we fund and we are excited to focus on their promising paths of discovery. New donors, both large and small, have come forward to join us as our message spreads. Each year we are continually touched by the tributes and memorial gifts given by families who have lost loved ones to psychiatric illness.

We promise our donors that we will keep propelling forward. Our Scientific Council will continue to identify the most creative Herbert Pardes, M.D. President, Scientific Council proposals for funding, helping to accelerate the pace of research and will focus on new approaches with the greatest potential for breakthroughs.

BOARD OF DIRECTORS OFFICERS DIRECTORS PUBLICATION CREDITS President & CEO Chairman Carol Atkinson Writers Jeffrey Borenstein, M.D. Stephen A. Lieber Donald M. Boardman Becky Ham J. Anthony Boeckh Peter Tarr, Ph.D. President, Scientific Council Vice President Susan Lasker Brody, MPH Herbert Pardes, M.D. Anne E. Abramson Suzanne Golden Editor Secretary Bonnie D. Hammerschlag Lauren Duran John B. Hollister John Kennedy Harrison II Treasurer Carole H. Mallement Designer Arthur Radin, CPA Milton Maltz Jenny Reed Marc R. Rappaport Virginia M. Silver Kenneth H. Sonnenfeld, Ph.D., J.D. Barbara K. Streicker Barbara Toll Robert Weisman, Esq.

www.bbrfoundation.org 7 2017 LEADING RESEARCH ACHIEVEMENTS BY FOUNDATION GRANTEES

“These research achievements were selected for highlight because of their significant contributions to our understanding of brain and behavior disorders as well as potential new treatments. This list illustrates some of the major research achievements by our grantees over the past year. We are proud to be able to say that our grants make critical differences in the careers of scientists and have helped support a broad range of the best ideas in brain research and that our grantees have taken substantial steps forward on the path to developing new treatments and finding cures for mental illness.”

—Jeffrey Borenstein, M.D.

8 ANNUAL REPORT 2017 Neurofeedback App Improves Early Cognitive 1 Deficit in People with High Psychosis Risk

Brain Abnormalities Linked to Suicidal 2 Behavior in Young People with Bipolar Disorder

Discovery of Four Depression “Biotypes” 3 Could Help Target Treatments

Deep Transcranial Magnetic Stimulation 4 (dTMS) Could Help Treat Bipolar Depression

Early Test Shows: Experimental Drug May 5 Have Potential to Relieve OCD Symptoms Quickly and with Few Side Effects

Animal Studies Suggest a New Path to 6 Fast–Acting Antidepressant

New Technique Lets Researchers Watch 7 Circuits Begin to Wire–Up

Ketamine Rapidly Reduced Suicidal 8 in People with Depression

Study Shows Exposure to Bright Light at 9 Midday Reduces Depression in Patients with Bipolar Disorder

New Analysis Finds Behavioral Therapy Should 10 Be Combined with Medication to Relieve Severe Anxiety in Children

Listed in order of publication

www.bbrfoundation.org 9 1.

Next-Generation Therapies: Psychosis, Schizophrenia

Jimmy Choi, Psy.D. The Institute of Living at Hartford Hospital, Connecticut

2010 Young Investigator

Neurofeedback App Improves Early Cognitive Deficit in People with High Psychosis Risk

Problems with mental processing speed are common among The results of the training showed that not only it is possible people at high risk for psychosis, and are to be related to improve processing speed, but that the effects remain up to broader deficits in social functioning. In a new clinical trial, to at least two months. Moreover, improvement in processing researchers enhanced participants’ processing speed using a speed was linked to better social functioning, as reported by neurofeedback training program and saw improvements in social the participants. behaviors, they report in Psychiatric Rehabilitation Journal. Addressing cognitive deficits in high-risk individuals early on could Processing speed is a measure of cognitive efficiency and it in- reduce functional decline later if they go on to develop full-blown volves the ability to effortlessly perform routine cognitive tasks so psychosis. The results of this clinical trial suggest that targeting as to free up processing capacity for other tasks. Low processing processing speed can be a promising approach to decreasing speed would reduce the ability to simultaneously handle multiple comorbidity and mitigating a risk factor for psychosis, the cognitive chores, such as processing social cues. This, researchers researchers say. say, gives the impression that the person is a “step behind” in a social situation, and may ultimately lead to social isolation. Journal: Psychiatric Rehabilitation Journal, February 15, 2017

Teenagers and young adults at high risk for schizophrenia have *The research team also included Cheryl Corcoran, M.D., of Medical Center and a Young Investigator grantee in 1999, 2002; been found to show processing speed impairments early on, before Daniel C. Javitt, M.D., Ph.D., of Columbia University Medical Center, who exhibiting any psychotic symptoms. In a randomized clinical trial is a 1990 Young Investigator grantee and 1995 Independent Investigator grantee, as well as a member of the Foundation's Scientific Council; and with 62 people at high risk for psychosis, Jimmy Choi, Psy.D., of Godfrey D. Pearlson, M.D., of The Institute of Living at Hartford Hospital, The Institute of Living at Hartford Hospital in Connecticut and a who is a 2000 Distinguished Investigator Grantee and a member of the 2010 Young Investigator grantee, and his colleagues* tested the Scientific Council. feasibility and outcome of improving processing speed through a personalized training program. The processing-speed training was done using a tablet-based program, in which the difficulty levels of training tasks are personalized. The program tracks participants’ eyes and uses their pupillary responses to determine the difficulty of a task. The program then uses this information to adjust train- ing parameters in real-time and change the cognitive load of the task. This results in a personalized and efficient training program.

10 ANNUAL REPORT 2017 2.

Basic Research: Bipolar Disorder, Suicide Prevention

Hilary P. Blumberg, M.D. School of Medicine 2006 Klerman Prizewinner 2006 Independent Investigator Foundation Scientific Council Member 2002 Young Investigator

Brain Abnormalities Linked to Suicidal Behavior in Young People with Bipolar Disorder

A new study of adolescents and young adults with bipolar disorder had attempted suicide. Abnormalities in these brain regions have has found structural and functional differences in the of also been observed in adults with various psychiatric disorders those with the disorder who have attempted suicide and those who have attempted suicide. who have not. It has been estimated that about half of people who have bipolar disorder make at least one suicide attempt in Zeroing in on the neural systems that underlie suicidal behavior their lifetime. The differences uncovered in the study could help is critical for developing new strategies for prevention, the researchers identify young people who are at greatest risk. researchers say. Their findings could help researchers develop interventions that aim to prevent suicide by improving function Although people with bipolar disorder tend to start having suicidal of these disrupted brain circuits. thoughts in adolescence or young adulthood–when parts of the brain involved in emotional processing are still maturing–few Journal: American Journal of Psychiatry, February 21, 2017 studies have examined neural circuitry associated with suicidal behavior in individuals at this age.

In the new study, published January 31 in the American Journal of Psychiatry, researchers led by Hilary P. Blumberg, M.D., used several different types of magnetic resonance imaging (MRI) to study the brains of people with bipolar disorder between the ages of 14 and 25, comparing 26 individuals who had attempted suicide to 42 who had not. Dr. Blumberg is a 2002 Young Investigator, 2006 Independent Investigator, BBRF Scientific Council member and 2006 Klerman Prizewinner.

The team, which included 2008 and 2012 Young Investigator Fei Wang, Ph.D., and 2016 Young Investigator Jie Liu, Ph.D., found that among those who had attempted suicide, parts of the brain that regulate emotion and impulses were smaller in size and less active than they were in the other study participants. The white matter connecting those brain regions was also diminished in those who

www.bbrfoundation.org 11 3.

Diagnostic Tools & Early Intervention: Depression

Conor Liston, M.D. Weill Cornell Medical College

2016 Freedman Prize Honorable Mention 2013 Young Investigator

Discovery of Four Depression “Biotypes” Could Help Target Treatments

Tests for various substances in the blood are one example of the brain’s state of activity when not engaged in a conscious task, the power of “biomarkers,” measurable biological traits that tell like reading. They examined how 258 different brain areas inter- doctors a patient either has or is at risk for a particular illness. acted with one another while in the resting state, and these brain While such tests so far have mostly eluded psychiatry, a large new circuit-level differences revealed four biotypes of depression. brain-scan study identified four categories of biological activity, or “biotypes,” of depression that may help doctors choose more Brains of patients who had depressive anxiety tended to have effective treatments – just as a blood test might guide treatment fewer connections in the brain networks involved in responses of a cancer or heart disease. to fear and negative emotional stimuli. Those with difficulty feeling pleasure, a condition called anhedonia, had more When researchers used a machine program to divide over connections in networks that regulate reward processing and 450 depression patients into categories based on biomarkers in control over movement. their brain activity patterns, they found four categories associated with distinct sets of clinical symptoms, according to their report in Noting that “biomarkers have already transformed the diagnosis the journal Medicine. and management of cancer, diabetes, heart disease and even pain syndromes,” the researchers express hope that the biotypes they Strikingly, patients in one of these four categories were about have identified will allow doctors to more specifically diagnose three times more likely to respond to a noninvasive treatment depression and determine the most effective treatment plan. known as transcranial magnetic stimulation (TMS) than patients in two of the other categories. TMS is a therapy in which magnetic Journal: Nature Medicine, April 10, 2017 fields stimulate specific regions of the brain, and has been particularly useful in cases of treatment-resistant depression. *Other BBRF grantees on the research team included: Scientific Council Member, 2015 Ruane Prizewinner BJ Casey, Ph.D.; 2010 Young Investigator Marc J. Dubin, M.D., Ph.D.; 2016 Young Investigator Amit Etkin, M.D., Ph.D.; Many of the scientists* on the team have received support from 2012 and 2009 Young Investigator Jennifer Keller, Ph.D.; Scientific Council Member, 1995 Independent Investigator and 1991 Young Investigator the BBRF during their careers. The lead investigator on the study, Helen S. Mayberg, M.D.; 2016 Young Investigator Desmond Jay Oathes, Conor Liston, M.D., is a 2013 Young Investigator grantee. Ph.D.; 2002 Distinguished Investigator and 1998 Independent Investigator Alvaro Pascual-Leone, M.D., Ph.D.; and Scientific Council Member, 2005 Falcone Prizewinner Alan F. Schatzberg, M.D. The team used functional magnetic resonance imaging (fMRI), a type of noninvasive brain scan that measures brain activity, to look for patterns in patients’ brains while in the “resting state”—

12 ANNUAL REPORT 2017 4.

Next-Generation Therapies: Bipolar Disorder Z. Jeff Daskalakis, M.D., Ph.D. Centre for Addiction and Mental Health, André R. Brunoni, M.D., Ph.D. University of Toronto, Canada University of São Paulo, Brazil Foundation Scientific Council Member 2013 Young Investigator 2008 Independent Investigator 2006, 2004 Young Investigator

Deep Transcranial Magnetic Stimulation (dTMS) Could Help Treat Bipolar Depression

Deep transcranial magnetic stimulation (dTMS), a non-invasive After four weeks, patients who received dTMS scored an average procedure that uses magnetic fields to stimulate brain cells, may of 4.88 points better on a survey measuring depression symptoms be useful when added to medication to treat bipolar depression, than those who received the placebo treatment. (A three-point according to a February 1 study published in the journal difference is considered to be a clinically meaningful difference, Neuropsychopharmacology. according to the National Institute of Clinical Excellence). Patients who received dTMS also showed a significant improvement in If these new results are confirmed in further studies, dTMS could overall functioning after four weeks, compared to the placebo join the limited options available for treating bipolar depression, group. However, the differences between groups in depression in which resistance to treatment is two times higher than in major symptoms and functioning had disappeared by eight weeks after (unipolar) depression. dTMS has already been shown to improve the start of treatment, and there were no significant differences in symptoms in patients with major depression. remission rates between the groups.

The study of dTMS in bipolar depression was led by Dr. André Patients who received dTMS reported more scalp pain than those R. Brunoni, of the University of São Paulo, Brazil, a 2013 Young in the placebo group, but there were no other differences in treat- Investigator, and included Z. Jeff Daskalakis, M.D., Ph.D., of the ment side effects. None of the patients developed mania symptoms Centre for Addiction and Mental Health, University of Toronto, a after the treatment (a condition called treatment-emergent mania recipient of 2004 and 2006 Young Investigator awards and a 2008 switch or TEMS), which can occur in dTMS treatment. The results Independent Investigator award. suggest that dTMS could be an effective and well-tolerated “add-on” therapy for patients with bipolar depression already taking medica- The study included 50 patients with bipolar depression who were tion, the researchers conclude, noting that these patients may also also currently taking psychiatric medication for their condition. benefit from a longer initial dTMS treatment program or mainte- In 20 sessions held over four weeks, half of the patients received nance treatments after the first treatment program. dTMS, which was delivered by an electrical coil inside a helmet worn by the participants. The other half of the patients received a The medical device company Brainsway provided financial support “placebo” treatment; that is, all the conditions were the same as for and the dTMS devices for the study. the dTMS group, except that the placebo patients wore a helmet with a coil that did not generate magnetic fields but produced the Journal: Neuropsychopharmacology, April 26, 2017 same sounds and scalp sensations as the active coil. Forty-three patients completed the study.

www.bbrfoundation.org 13 5.

Next-Generation Therapies: OCD Helen Blair Simpson, M.D., Ph.D. Columbia University College of Physicians Carolyn I. Rodriguez, M.D., Ph.D. and Surgeons School of Medicine 2010 Independent Investigator 2017 Klerman Prize Honorable Mention 2005 Young Investigator 2014, 2009 Young Investigator

Early Test Shows: Experimental Drug May Have Potential to Relieve OCD Symptoms Quickly and with Few Side Effects

According to a new study, rapastinel, an experimental drug in learning, and synaptic plasticity and thought to play currently being evaluated for the treatment for major depression, a role in OCD. But rapastinel works differently than ketamine may relieve the symptoms of obsessive-compulsive disorder and has a lower risk of causing dissociative side effects, the (OCD) rapidly and with few side effects. researchers say.

Results of the small proof-of-concept study, led by 2009 and 2014 Seven people with OCD participated in the team’s initial clinical Young Investigator Carolyn I. Rodriguez, M.D., Ph.D., at Stanford study. Each was given a single dose of rapastinel. The drug was University School of Medicine, were reported December 1, 2016 in well tolerated—no patient reported dissociative side effects—and The American Journal of Psychiatry. Helen Blair Simpson, M.D., Ph.D., within hours of treatment, the severity of patients’ symptoms had a 2005 Young Investigator and 2010 Independent Investigator at declined significantly. The drug reduced the severity of patients’ Columbia University College of Physicians and Surgeons, was also obsessions and compulsions, as well as symptoms of anxiety and a member of the research team. depression, the researchers report.

Rodriguez and her colleagues are investigating rapastinel because While rapastinel’s effects on OCD symptoms were rapid, they were they previously found that some OCD patients receive rapid relief not long-lasting. When the research team evaluated patients one from their symptoms when treated with ketamine. Ketamine has week after treatment, symptoms were about as severe as they long been used as an anesthetic, and in recent years researchers had been prior to treatment. The scientists say important next have found that it can also rapidly relieve symptoms of depression. steps will be testing the effects of repeated dosing and working However, the drug’s side effects, which include a feeling of dissoci- to develop related drugs that reduce OCD symptoms over a ation—a sense of detachment from one’s self, or an “out-of-body” sustained period. experience—are a challenge for broad clinical use in treating psychiatric disorders. Journal: American Journal of Psychiatry, May 22, 2017

Hoping to find a treatment that reduces patients’ obsessions and compulsions quickly without dissociative side effects, Rodriguez and her colleagues have turned to rapastinel. It, like ketamine, is a drug that modulates the action of NMDA receptors in the brain– docking ports for the glutamate and important

14 ANNUAL REPORT 2017 6.

Next-Generation Therapies: Depression

Abraham A. Palmer, Ph.D. University of California, San Diego

2006, 2003 Young Investigator

Animal Studies Suggest a New Path to Fast-Acting Antidepressant

Animal research reported on March 21 in the journal Molecular Depression-like behaviors declined within five days of treatment Psychiatry has uncovered a drug development strategy that for the animals in which GLO1 had been inhibited. Depression-like could lead to a new type of antidepressant medication. The behaviors also declined in animals that were given Prozac, but for study suggests that inhibiting an enzyme called GLO1 could have this group, it took two weeks for the antidepressant to take effect. fast-acting antidepressant effects, relieving patients’ symptoms The scientists say inhibiting GLO1 likely increases the level of a in a matter of days. Existing antidepressant medications can brain chemical called methylglyoxal, which influences neural take weeks or months to become fully effective, and do not help signaling. They are now working with medicinal chemists to try a considerable fraction of patients. Finding other, faster-acting to develop better GLO1-inhibiting compounds. These could give alternatives is a high priority. rise to a new, faster-acting treatment for depression, the team says. With further research, this may become a new strategy for The study was led by Abraham A. Palmer, Ph.D., a 2003 and treating depression. 2006 Young Investigator at the University of California, San Diego (UCSD). Dr. Palmer and his colleagues had previously discovered Journal: Molecular Psychiatry, June 12, 2017 that inhibiting GLO1 can reduce anxiety-like behaviors in mice, and several studies have hinted that overactivity of GLO1 might *Other BBRF grantees on the research team included: 2016 Independent Investigator, 2012 and 2007 Young Investigator Stephanie Dulawa, Ph.D.; also contribute to depression. So the team was curious whether and 2016 Young Investigator Marcia J. Ramaker, Ph.D. inhibiting the enzyme might be an effective way to treat major depression.

The researchers* reduced the activity of GLO1 in mice, by genetic manipulation or by administering two different GLO1- inhibiting chemicals.

Then they evaluated the animals’ behavior. They used several established tests to measure depression-like behavior in the animals, such as observing how hard they tried to escape difficult situations and how they coped with chronic mild stress. They performed the same tests with untreated mice and also with mice given the popular antidepressant medication fluoxetine (Prozac).

www.bbrfoundation.org 15 7.

New Technology: Autism, Schizophrenia

Sergiu P. Pasca, M.D. Stanford University

2017 Independent Investigator 2012 Young Investigator

New Technique Lets Researchers Watch Human Brain Circuits Begin to Wire-Up

Scientists have devised a new system that lets them watch human migrate normally toward the excitatory cells. The cells did grown in the lab find and form connections with their migrate properly, however, when they were treated with a drug signaling partners, an essential process in developing human that blocks a receptor located on the surface of neurons that brains. The processing of “wiring up” is thought to go awry in channels calcium atoms. a number of serious disorders, including autism, and schizophrenia– but it’s hard to study. Overactivity of these channels is associated with Timothy syndrome. The brain-region specific spheroid system will be a The new technique, published May 4 in Nature, focused on the useful model for studying such developmental abnormalities and connections formed by cells called . These neurons their role in psychiatric disorders, the scientists say, and to build are key components of circuits in the brain’s . They other brain circuits in a dish. spend months growing and migrating to their destinations during fetal development, and in the cortex play an indispensable inhibi- Journal: Nature, July 18, 2017 tory, or “braking,” role in communication between neurons. *Other BBRF grantees on the research team included 1991 Young Investigator Joachim F. Hallmayer, M.D. To make it possible to watch interneurons migrate and begin to wire up with other cells, researchers led by Sergiu P. Pasca, M.D., a 2012 Young Investigator and a 2017 Independent Investigator at Stanford University, developed a system to recreate those processes in a lab dish. Dr. Pasca and his team* first reprogrammed human skin cells to grow into tiny balls of tissue, or brain spheroids, made up of specific types of neurons. They grew spheroids of interneurons and spheroids of the excitatory neurons to which interneurons connect in the brain.

They then fused the two types of spheroids together and watched the cells interact. The interneurons migrated toward cells in the other spheroid, then changed their shape and began forming connections with the excitatory cells.

In an experiment in which the spheroids were derived from cells donated by patients with Timothy syndrome, a genetic form of autism and epilepsy, interneurons did not

16 ANNUAL REPORT 2017 8.

Next-Generation Therapies: Depression, Suicide Prevention

Samuel Wilkinson, M.D. Yale University School of Medicine

2016 Young Investigator

Ketamine Rapidly Reduced Suicidal Thoughts in People with Depression

A single dose of ketamine, the anesthetic drug that has been colleagues focused on those participants who reported suicidal found to have fast-acting antidepressant effects, can significantly thoughts at the time of their trial. They analyzed ketamine’s ef- reduce suicidal thoughts in patients with depression for up to a fects upon both suicidal thoughts and scores on standard clinical week, according to a new analysis. depression scales, comparing patients’ responses to the drug to those of patients in control groups who received either saline or The findings, published online October 3, 2017 in theAmerican the anesthetic midazolam as a placebo. Journal of Psychiatry, come from data on 167 patients who partici- pated in any of 10 previous studies on ketamine’s effects. All of the The team found that both suicidal thoughts and overall depres- patients studied received a single dose of the drug or a control sion were relieved significantly by ketamine; more than half were drug, administered intravenously. This “meta-analysis”–a study of free of suicidal thoughts within 24 hours of their treatment. These multiple other studies – suggests that the drug not only reduces benefits persisted for up to a week—the latest time point consid- patients’ overall depression; it also appears to be particularly ered in the analysis. effective at countering suicidal thoughts. Overall, those whose depression diminished the most expe- Ketamine’s use as an antidepressant is experimental. Scientists rienced the greatest reductions in suicidal thoughts, but the have discovered that low doses of the drug can relieve symptoms researchers found that ketamine’s effects on suicidal ideation of depression within hours. Because ketamine is an old drug and were significant even after controlling for changes in depression is no longer protected by patent, it is unlikely to be tested in large severity. This means the drug’s effects on this critical aspect of clinical trials that are required for FDA approval. But researchers depression may be partially independent from its effects on mood, note that it can be particularly effective as a rapid antidepressant they say. This will undoubtedly be the focus of future research. and can rapidly reduce suicidal thinking. Multiple research efforts are devoted to inventing a ketamine-like drug that has its antide- Journal: American Journal of Psychiatry, October 10, 2017 pressant potency but lacks its side effects. *Other BBRF grantees on the research team included: 2013 and 2009 Young Investigator Michael H. Bloch, M.D., M.S.; 2015 Independent Investi- In the current study, researchers* led by 2016 Young Investigator gator and 2002 Young Investigator Adriana Feder, M.D.; 2009 Independent Samuel T. Wilkinson, M.D., at Yale School of Medicine, collected Investigator, 2006 and 2001 Young Investigator Sanjay J. Mathew, M.D.; 2009 Young Investigator James W. Murrough, M.D., Ph.D.; 2014 Distin- and analyzed data from past studies with the goal of better under- guished Investigator, 2007 Independent Investigator and a 2001 and 1999 standing ketamine’s acute effects on patients who are experienc- Young Investigator Gerard Sanacora, M.D., Ph.D.; and 2011 Bipolar Mood ing significant thoughts of suicide. Disorders Awardee, 2005 Independent Investigator and 1996 Young Investigator Carlos A. Zarate, Jr., M.D.

Participants in the 10 studies included in the new analysis had been diagnosed with a range of psychiatric conditions, including major depression and bipolar disorder. Dr. Wilkinson and his

www.bbrfoundation.org 17 9.

Next-Generation Therapies: Katherine L. Wisner, M.D., M.S. Bipolar Disorder, Depression Northwestern University

Dorothy K.Y. Sit, M.D. 1998 Independent Investigator Northwestern University

2013, 2002 Young Investigator

Study Shows Exposure to Bright Light at Midday Reduces Depression in Patients with Bipolar Disorder

Light therapy can be an effective treatment for seasonal depres- In an earlier study involving some of the same patients, Dr. Sit and sion, but there has been concern that the treatment might induce colleagues tested the effects of administering light therapy in the mania in people with bipolar disorder. Participants in the new trial morning, and found that some patients responded with episodes did not experience any manic episodes, despite daily exposure to of mania. Timing of light exposure may be critical for managing bright light. depression in patients with bipolar disorder, they say.

The study, published in the American Journal of Psychiatry, was led Journal: American Journal of Psychiatry, October 16, 2017 by 2013 and 2002 Young Investigator Dorothy K.Y. Sit, M.D., and 1998 Independent Investigator Katherine L. Wisner, M.D., M.S., both at Northwestern University.

Forty-six patients participated in the study. All had been diagnosed with bipolar disorder and were taking medication to manage the illness. At the time of the study, which for most participants began in the fall or winter, all patients were suffering from an episode of moderate depression.

Trial participants were randomly assigned to receive daily treat- ments of either bright white light or dim red light, with the red light serving as a placebo. Treatments were administered midday, beginning with 15 minutes of light exposure and increasing daily until treatments reached a duration of one hour. The light dose was similar to that used to treat seasonal affective disorder.

After six weeks of treatment, 68 percent of those who received bright light therapy experienced a remission of their depres- sion. In contrast, only 22 percent of those in the placebo group achieved remission.

18 ANNUAL REPORT 2017 10.

Next-Generation Therapies: Bipolar Disorder, Depression

Michael Howard Bloch, M.D., M.S. Yale Child Study Center

2013, 2009 Young Investigator

New Analysis Finds Behavioral Therapy Should Be Combined with Medication to Relieve Severe Anxiety in Children

Both therapy and anti-anxiety medications can help relieve the Of the 448 children and adolescents with generalized, social, or symptoms of anxiety in children and adolescents. According to separation anxiety disorders who participated in the trial, 220 new findings reported October 2 in the Journal ofClinical Child & had symptoms that were considered severe. The team found that Adolescent , however, children whose anxiety symptoms these patients achieved remission during the trial only if they are severe likely need both. received a combination of sertraline and CBT. For individuals with severe anxiety, remission rates following medication or behavioral The study, led by Michael H. Bloch, M.D., M.S., a 2013 and 2009 therapy alone were similar to those of study participants who Young Investigator and Associate Professor in the Yale Child Study received a placebo. Center, and his Yale colleague Professor Wendy K. Silverman, Ph.D., is a more detailed analysis of a previously reported trial in which The team also investigated factors that might make children more children and adolescents with anxiety disorders were randomly or less likely to respond to treatment. They found that anxiety was assigned to receive either cognitive behavioral therapy (CBT), the most resistant to treatment in children from lower socioeconomic antidepressant medication sertraline (Zoloft), a combination of backgrounds and in those who had been diagnosed with sertraline and CBT, or a placebo. obsessive-compulsive disorder (OCD).

While behavioral therapy combined with medication was found to Journal: Journal of Clinical Child & Adolescent Psychology, be most effective, the groups who received only CBT or sertraline November 14, 2017 also experienced an overall decline in anxiety symptoms after 12 weeks of treatment.

Based on those findings, which were reported in 2008, many doctors and parents have chosen behavioral therapy alone as a first-line treatment for childhood anxiety. After taking a closer look at the data, however, Dr. Bloch and colleagues, including 2017 Young Investigator Jerome H. Taylor, M.D., at the University of Pennsylvania and 2013 Young Investigator Eli R. Lebowitz, Ph.D., at Yale University, say patients with severe symptoms may be better off beginning with combination therapy.

www.bbrfoundation.org 19 OUR SCIENTIFIC COUNCIL

175 Members (7 Emeritus) 2 Nobel Prize Winners 2 Former Directors of the National Institute of Mental Health as well as the Current Director 4 Recipients of the National Medal of Science 13 Members of the National Academy of Sciences 26 Chairs of Psychiatry & Neuroscience Departments at Leading Medical Institutions 52 Members of the National Academy of Medicine

20 ANNUAL REPORT 2017 Our Scientific Council

PRESIDENT J. Raymond DePaulo, Jr., M.D. Robert H. Lenox, M.D. Gerard Sanacora, M.D., Ph.D. Herbert Pardes, M.D. Ariel Y. Deutch, Ph.D. Pat Levitt, Ph.D. Akira Sawa, M.D., Ph.D. Wayne C. Drevets, M.D. David A. Lewis, M.D. Alan F. Schatzberg, M.D. VICE PRESIDENT Ronald S. Duman, Ph.D. Jeffrey A. Lieberman, M.D. Nina R. Schooler, Ph.D. EMERITUS Stan B. Floresco, Ph.D. Kelvin Lim, M.D. Robert Schwarcz, Ph.D. Floyd E. Bloom, M.D. Judith M. Ford, Ph.D. Irwin Lucki, Ph.D. Philip Seeman, M.D., Ph.D. Alan Frazer, Ph.D. Gary Lynch, Ph.D. Yvette I. Sheline, M.D. Ted Abel, Ph.D. Robert R. Freedman, M.D. Robert C. Malenka, M.D., Ph.D. Solomon H. Snyder, M.D., Anissa Abi-Dargham, M.D. Fred H. Gage, Ph.D. Anil K. Malhotra, M.D. D.Sc., D.Phil. (Hon. Causa) Schahram Akbarian, M.D.,Ph.D. Aurelio Galli, Ph.D. Husseini K. Manji, M.D.,F.R.C.P.C. Vikaas Sohal, M.D., Ph.D. Huda Akil, Ph.D. Mark S. George, M.D. J. John Mann, M.D. Matthew State, M.D. Susan G. Amara, Ph.D. Elliot S. Gershon, M.D. John S. March, M.D., M.P.H. Murray Stein, M.D., M.P.H. Stewart A. Anderson, M.D. Mark A. Geyer, Ph.D. Stephen Maren, Ph.D. John S. Strauss, M.D. Nancy C. Andreasen, M.D.,Ph.D. Jay N. Giedd, M.D. Daniel Mathalon, Ph.D., M.D. J. David Sweatt, Ph.D. Amy F.T. Arnsten, Ph.D. Jay A. Gingrich, M.D., Ph.D. Helen S. Mayberg, M.D. John A. Talbott, M.D. Gary S. Aston-Jones, Ph.D. David Goldman, M.D. Bruce S. McEwen, Ph.D. Carol A. Tamminga, M.D. Jay M. Baraban, M.D., Ph.D. Joshua A. Gordon, M.D., Ph.D. Ronald McKay, Ph.D. Laurence H. Tecott, M.D.,Ph.D. Deanna Barch, Ph.D. Elizabeth Gould, Ph.D. James H. Meador-Woodruff, Ming T. Tsuang, M.D., Ph.D., Jack D. Barchas, M.D. Anthony A. Grace, Ph.D. M.D. D.Sc. Samuel H. Barondes, M.D. , Ph.D. Herbert Y. Meltzer, M.D. Kay M. Tye, Ph.D. Carrie Bearden, Ph.D. Raquel Gur, M.D., Ph.D. Kathleen Merikangas, Ph.D. Leslie G. Ungerleider, Ph.D. Francine M. Benes, M.D., Ph.D. Suzanne N. Haber, Ph.D. Richard J. Miller, Ph.D. Flora Vaccarino, M.D., Ph.D. Karen F. Berman, M.D. Philip D. Harvey, Ph.D. Karoly Mirnics, M.D., Ph.D. Rita J. Valentino, Ph.D. Wade H. Berrettini, M.D., Ph.D. Stephan Heckers, M.D. Bita Moghaddam, Ph.D. Jim van Os, M.D., Ph.D., Randy D. Blakely, Ph.D. René Hen, Ph.D. Charles B. Nemeroff, MRCPsych Pierre Blier, M.D., Ph.D. Fritz A. Henn, M.D., Ph.D. M.D., Ph.D. Jeremy Veenstra-VanderWeele, Hilary Blumberg, M.D. Takao Hensch, Ph.D. Eric J. Nestler, M.D., Ph.D. M.D. Antonello Bonci, M.D. Robert M.A. Hirschfeld, M.D. Andrew A. Nierenberg, M.D. Susan Voglmaier, M.D., Ph.D. Robert W. Buchanan, M.D. L. Elliot Hong, M.D. Patricio O’Donnell, M.D., Ph.D. Nora D. Volkow, M.D. Peter F. Buckley, M.D. Steven E. Hyman, M.D. Dost Ongur, M.D., Ph.D. Mark von Zastrow, M.D., Ph.D. Ed Bullmore, Ph.D. Robert B. Innis, M.D., Ph.D. Steven M. Paul, M.D. Karen Dineen Wagner, M.D., William E. Bunney, Jr., M.D. Jonathan A. Javitch, M.D.,Ph.D. Godfrey D. Pearlson, M.A., Ph.D. Joseph D. Buxbaum, Ph.D. Daniel C. Javitt, M.D., Ph.D. M.B.B.S. Daniel R. Weinberger, M.D. William Byerley, M.D. Dilip Jeste, M.D. Mary L. Phillips, M.D. (CANTAB) Myrna M. Weissman, Ph.D. Ty Cannon, Ph.D. Ned Kalin, M.D. Marina Picciotto, Ph.D. Marina Wolf, Ph.D. William Carlezon, Ph.D. Peter W. Kalivas, Ph.D. Daniel S. Pine, M.D. Jared W. Young, Ph.D. Marc G. Caron, Ph.D. Eric R. Kandel, M.D. Robert M. Post, M.D. L. Trevor Young, M.D., Ph.D. William T. Carpenter, Jr., M.D. Richard S.E. Keefe, Ph.D. James B. Potash, M.D., M.P.H. Jon-Kar Zubieta, M.D., Ph.D. Cameron S. Carter, M.D. Samuel J. Keith, M.D. Steven G. Potkin, M.D. BJ Casey, Ph.D. Martin B. Keller, M.D. Pasko Rakic, M.D., Ph.D. MEMBERS EMERITUS Bruce M. Cohen, M.D., Ph.D. John R. Kelsoe, M.D. Judith L. Rapoport, M.D. George K. Aghajanian, M.D. Jonathan D. Cohen, M.D., Ph.D. Kenneth S. Kendler, M.D. Perry F. Renshaw, M.D., Dennis S. Charney, M.D. Peter Jeffrey Conn, Ph.D. James L. Kennedy, M.D. Ph.D., M.B.A. Jan A. Fawcett, M.D. Edwin Cook, M.D. Robert M. Kessler, M.D. Kerry J. Ressler, M.D., Ph.D. Frederick K. Goodwin, M.D. Richard Coppola, D.Sc. Mary-Claire King, Ph.D. Victoria Risbrough, Ph.D. Lewis L. Judd, M.D. Rui Costa, Ph.D., HHMI Rachel G. Klein, Ph.D. Carolyn B. Robinowitz, M.D. Kenneth K. Kidd, Ph.D. Joseph T. Coyle, M.D. John H. Krystal, M.D. Bryan L. Roth, M.D., Ph.D. Jacqueline N. Crawley, Ph.D. Amanda J. Law, Ph.D. Laura Rowland, Ph.D. John G. Csernansky, M.D. James F. Leckman, M.D. John L.R. Rubenstein, M.D., Z. Jeff Daskalakis, M.D., Ph.D. Francis S. Lee, M.D., Ph.D. Ph.D. , M.D., Ph.D. Ellen Leibenluft, M.D. Bernardo Sabatini, M.D., Ph.D.

www.bbrfoundation.org 21 OUR NEWEST SCIENTIFIC COUNCIL MEMBERS

Led by Dr. Herbert Pardes, the founding President of our Scientific Council, the all-volunteer group of pre-eminent mental health researchers review more than 1,200 grant applications each year and select the most promising research ideas with the greatest potential to lead to breakthroughs.

The Scientific Council guides the Foundation to fund creative and impactful research rele- vant to the whole spectrum of mental health.

We welcome our newest members.

“The reach of the Brain & Behavior Research Foundation’s Grants knows no borders. Research projects are selected by the Foundation’s Scientific Council comprised of leading experts across disciplines in brain and behavior research. The impact of our effort is not only in the development of promising scientists, but also in the focus it brings to the challenge and urgent need of bringing hope and better lives to all those living with mental illness.”

—Dr. Herbert Pardes

22 ANNUAL REPORT 2017 CARRIE E. BEARDEN, PH.D. received ANTONELLO BONCI, M.D. joined the EDWARD THOMAS BULLMORE, MB, her Ph.D. in Clinical Psychology from the National Institutes of Health (NIH) in PH.D., FRCP, FRCPSYCH, FMEDSCI University of Pennsylvania and joined the 2010 as Scientific Director of the National trained in medicine at the University UCLA faculty in 2003. Currently, she is a Institute on Drug Abuse (NIDA). Dr. Bonci’s of Oxford and St. Bartholomew’s Professor (George and Joanne Miller Family laboratory was the first to demonstrate Hospital, London; then in psychiatry at Endowed Term Chair) at the Semel Institute that drugs of abuse such as cocaine the Bethlem Royal & Maudsley Hospital, for Neuroscience and Human Behavior, with produce long-lasting modifications on London. He moved to Cambridge as a joint appointment in the Department of the strength of the connections between Professor of Psychiatry in 1999 and Psychology at UCLA. Dr. Bearden's research neurons. This form of cellular memory is currently Scientific Director of the aims to understand neurobiological risk fac- is called long-term potentiation (LTP). Wolfson Brain Imaging Centre, and Head tors for the development of serious mental This finding cast a new light on the of the Department of Psychiatry, in illness, using converging methods to study phenomenon of drug addiction, which the University. He is also an honorary cognition and neuroanatomy in clinical may represent a process of maladaptive Consultant Psychiatrist and Director of high-risk samples (e.g., adolescents with learning and memory at the cellular level. R&D in Cambridgeshire & Peterborough early symptoms of psychosis), and in highly In turn, this information helped explain Foundation NHS Trust; and, since 2005, he penetrant genetic subtypes of the illness. why drug taking can often become such a has worked half-time for GlaxoSmithKline, Her recent work focuses on translational long-lasting phenomenon. Subsequently, currently focusing on immuno-psychiatry. approaches to understanding disrupted his work has used a combination of He has published more than 500 scientific brain circuitry in developmental neuropsy- , optogenetic, molecular papers and his work on brain network chiatric disorders, particularly in the context and behavioral procedures to keep on science and brain imaging has been highly of unique genetic populations. She is the studying the basic cellular mechanisms cited. He has been elected a Fellow of Director of the Staglin Music Festival Center and circuits underlying stress, reward the Royal College of Physicians, the Royal for the Assessment and Prevention of and substance use disorders. His lab is College of Psychiatrists, and the Academy Prodromal States (CAPPS), and is the UCLA currently developing an optogenetic-based of Medical Sciences. Principal Investigator of the multi-site North treatment against cocaine use disorders, American Prodromal Longitudinal Study by using a non-invasive technique called “I joined the Council because I believe (NAPLS) Consortium. She also co-directs a transcranial magnetic stimulation. in the mission of BBRF, and think BBRF Neurobehavioral Genetics Training Grant does a great job in funding mental at UCLA, serves on the DSM-V Revision “I'm honored to serve the Foundation health research that is generally Committee, and on the Editorial Boards because I've admired for many years under-funded in proportion to the of Biological Psychiatry, the Foundation’s extraordinary work level of unmet clinical need. I was and Schizophrenia Bulletin. Dr. Bearden has and commitment toward helping attracted to serve alongside the received numerous awards and honors, scientists.” outstanding clinicians and scientists both for her research achievements and for already on Council.” teaching and mentorship. • 2004 Distinguished Investigator “I am particularly honored to join the Scientific Council because the Foun- “The Foundation is a driving in dation was essential for launching my advancing the understanding of mental career as an independent scientist. I illness, and we are able to do that thanks am forever grateful for the opportu- to the generosity of our donors and the nity that first Young Investigator grant gave me, and am excited to play a dedication of our Scientific Council members. larger role in the society that had faith Over the past 30 years, they have reviewed in me ‘way back when.” more than 25,000 grant applications.”

• 2005 & 2003 Young Investigator —Dr. Jeffrey Borenstein

www.bbrfoundation.org 23 TYRONE D. CANNON, PH.D. is the Clark L. ZAFIRIS J. DASKALAKIS, M.D., PH.D., KELVIN LIM, M.D., holds the Drs. T. J. Hull Professor of Psychology and Professor FRCP(C) is a Professor of Psychiatry, and Ella M. Arneson Land-Grant Chair of Psychiatry at Yale University. Dr. Cannon Temerty Chair in Therapeutic Brain in Human Behavior at the University of earned his bachelor’s degree at Dartmouth Intervention and Chief of the Mood and Minnesota where he is a Professor of College (1985) and his doctoral degree at Anxiety Division at CAMH. The Temerty Psychiatry and Vice Chair for Research. the University of Southern California (1990). Centre uses magnetic brain stimulation Dr. Lim began his undergraduate work at He took his first academic appointment to study the role of cortical inhibition, the Massachusetts Institute of Technology, in the Department of Psychology at the plasticity and connectivity as potential completing his Bachelor and M.D. degrees University of Pennsylvania, where he pathophysiological mechanisms in at Johns Hopkins University. He completed advanced to Associate Professor. He schizophrenia, depression and obsessive a psychiatry residency and fellowship joined the faculty at UCLA in 1999 as compulsive disorder. Dr. Daskalakis in at Stanford University Professor of Psychology and Psychiatry also conducts treatment studies using where he also served on the faculty in the and Biobehavioral Sciences, before moving repetitive transcranial magnetic brain Department of Psychiatry. He joined the to his current position at Yale in 2012. Dr. stimulation (rTMS), magnetic seizure University of Minnesota in 2001. Cannon’s research addresses the interplay therapy (MST) and electroconvulsive between psychological-level phenomena therapy (ECT) for resistant symptoms in “I am honored to join the Foundation’s and neurobiological mechanisms as they these disorders. He has received several Scientific Council. The Foundation relate to disturbances of , belief, national and international awards and serves a critical role in launching new motivation, and emotional processing distinctions including the Samarthji Lal investigators and catalyzing new in people with mental illness, principally Award in Mental Health Research from the research ideas. I know this first hand; schizophrenia. A primary aim of his work Graham Boeckh Foundation for the top my first grant was a Young Investiga- is to identify mechanisms underlying the mid-career neuropsychopharmacology tor Award which was critical to launch- emergence of psychosis during adolescence researcher in Canada in 2013. He also ing my research career. I am delighted and early adulthood and to develop holds or has held NIMH and CIHR peer- to be able to directly support the effective intervention and prevention reviewed funding and has also mentored mission of the Foundation.” strategies targeting these mechanisms. numerous BBRF Young Investigator awardees. Finally, he has over 290 peer- • 1999 & 1989 Young Investigator “I agreed to join the Scientific Council reviewed publications, books and book because I am committed to the field chapters and is an editorial board member of psychiatric disorders and to the de- for Biological Psychiatry and an Associate velopment and promotion of junior in- Editor for Clinical Neurophysiology. vestigators, and the BBRF contributes substantially to these goals through “The Brain & Behavior Research its research awards programs.” Foundation is one of the most coveted and valued awards for any investigator in the field of psychiatry • 2006 Distinguished Investigator and neuroscience. The Foundation’s • 1997 Independent Investigator impact on our field is remarkable and as a previous award winner, there is no greater privilege than to be able to reciprocate the Foundation’s generous support by serving on the Scientific Council with some of the greatest luminaries in our field.”

• 2008 Independent Investigator • 2006 & 2004 Young Investigator

24 ANNUAL REPORT 2017 STEPHEN MAREN, PH.D. is the Claude VICTORIA RISBROUGH, PH.D. is a LAURA M. ROWLAND, PH.D. is an H. Everett, ’47 Jr. Chair of Liberal Arts, Professor of Psychiatry at the University of Associate Professor in the Professor of Psychology, and Presidential California San Diego and Associate Director Psychiatric Research Center (MPRC), Impact Fellow at Texas A&M University. of Neuroscience for the Center of Excellence Department of Psychiatry at the University He is also a member of the Texas A&M for Stress and Mental Health for Veterans of Maryland, School of Medicine. She University Institute for Neuroscience. Affairs. Her research is centered on is the Director of the Chemical Imaging Dr. Maren’s research seeks to understand translational mechanisms and treatments Core, housed within the Neuroimaging the neural basis of anxiety disorders and of anxiety and depression particularly Research Program at the MPRC and the post-traumatic stress disorder (PTSD). His trauma-related disorders. She leads a co-director of the MPRC post-doctoral research on the neurobiology of Pavlovian dual preclinical/clinical research program training program. Supported by NIMH fear conditioning and in animals focusing on identifying mechanisms of and BBRF, her research focuses on has revealed interactions between a risk and resilience to post-traumatic stress proton magnetic resonance spectroscopy triad of interconnected brain areas, disorder, as well as development of new studies of glutamatergic and GABAergic including the , amygdala, and pharmacological treatments for these function and bioenergetic alterations in prefrontal cortex that are essential for the disorders. Her preclinical laboratory uses schizophrenia and related disorders. Her regulation of emotional memory. Dr. Maren behavioral, pharmacological, genetic and research program integrates these in vivo is a recipient of the American Psychological molecular techniques to identify genetic neurochemistry measures with functional Association (APA) Distinguished Scientific and circuit mechanisms of enduring trauma paradigms, multimodal neuroimaging, and Award for an Early Career Contribution responses. Her clinical work examines translational to to Psychology (2001) and the D. O. Hebb mechanisms underlying core disruptions better understand perceptual and learning Distinguished Scientific Contributions of fear learning and inhibition in trauma- mechanisms, aging/illness course, and Award (2017). He is also a Fellow of the related disorders, as well as development of novel treatments in schizophrenia and American Psychological Association and novel pharmacological treatments targeting related disorders. In addition to research Association for Psychological Science, Past- these mechanisms. She is on the Scientific and training, Dr. Rowland currently serves President of the Pavlovian Society, and is Council for the Anxiety and Depression as co-director for the Young Investigator currently the Editor-in-Chief of Behavioural Association of America, is a Member of the Program for the International Congress on Brain Research. He has been continuously American College of Schizophrenia Research, Associate Editor funded by the NIH since 1995 and is a and is Associate Editor of Neurobiology for Schizophrenia Bulletin, and a member of recipient of the 2015 McKnight Memory of Stress. an NIH study section. and Cognitive Disorders award. “Receiving a Young Investigator Award • 2017 Independent Investigator “It is an honor to join the Foundation was a major catalyst for me to start • 2006 Young Investigator Scientific Council to help serve its my career in PTSD research, and has mission to support the most prom- continued to be so for my trainees. ising research on the biological basis The Foundation is a cornerstone of mental disorders. I have no doubt for the neuropsychiatric discipline that these efforts will go a long way to in nurturing the next generation of relieve the burden that mental illness scientists that are developing inno- levies on afflicted individuals, their vative and transformative research families, and society at large.” programs. I am honored to give back to the foundation that gave me ‘a leg up’ and encouragement at a critical juncture of my career.”

• 2006 Young Investigator

www.bbrfoundation.org 25 VIKAAS SINGH SOHAL, M.D. studied FLORA VACCARINO, M.D., PH.D. is JEREMY VEENSTRA-VANDERWEELE, applied mathematics at Harvard and the Harris Professor at the Child Study M.D. is the Mortimer D. Sackler, MD, Cambridge before completing his M.D. Center and Professor of Neuroscience Professor, and Director of the Division and Ph.D. degrees at Stanford. During at Yale University. She directs the of Child and Adolescent Psychiatry at his psychiatry residency at Stanford, he Developmental Neurobiology Laboratory Columbia University and the New York worked with Dr. Karl Deisseroth on some and the Program in Neurodevelopment State Psychiatric Institute. He is a child of the first experiments using optogenet- and Regeneration at Yale University. Her and adolescent psychiatrist who uses ics to study the function of brain circuits. lab uses animal models and human brain molecular and translational neuroscience In 2010, he started his laboratory at the tissue to unravel the pathophysiology of research tools in the pursuit of new University of California, San Francisco, neuropsychiatric disorders. She pioneered treatments for autism spectrum disorder which studies how circuits in the prefrontal a “cortical organoid” model, where human and pediatric obsessive compulsive cortex produce patterns of brain activity brain organoids derived from induced disorder. His molecular laboratory that contribute to normal cognition as well pluripotent stem cells (iPSCs) grown in focuses on the transporter as symptoms of psychiatric disorders. Dr. a tri-dimensional culture recapitulate and neuronal glutamate transporter in Sohal is a board-certified psychiatrist and the early development of the human genetic mouse models with abnormal continues to see outpatients one half-day telencephalon. Dr. Vaccarino participates social or compulsive-like behavior. His each week. in the PsychENCODE consortium, and translational research program at the her lab is mapping noncoding RNAs NewYork-Presbyterian Hospital Center for “Finding cures for mental illness is and functional DNA elements in human Autism and the Developing Brain studies incredibly important to me both iPSCs, brain organoids and corresponding potential treatments for autism spectrum personally and professionally. postmortem fetal human brain specimens. disorder and related genetic syndromes. Having an opportunity to work with She is part of the Brain Somatic Mosaicism Dr. Veenstra-VanderWeele’s work has leaders in the field to identify the Network, a NIMH-sponsored consortium been recognized with a number of awards, most promising new directions is that studies somatic genomic variation including the Blanche Ittelson Award for an incredible opportunity for me to in neurodevelopmental disorders. Dr. Research in Child and Adolescent Psychiatry contribute to this enterprise and keep Vaccarino is a member of the Kavli Institute from the American Psychiatric Association. informed about the most cutting for Neuroscience at Yale and Fellow of the edge research. I have benefited from American Association for the Advancement “I am excited to join the Scientific a Foundation grant in the past, and it of Science. Council because the Foundation played a critical role in helping my lab supports early investigators who get off the ground. So, I now I look to “I have been helped by the Foundation are often pursuing the first project helping this organization carry on this in the crucial transition between train- that is truly their own idea, including essential work.” ing and independence. I would like to support that I was fortunate to have contribute to the continued effort of early in my career. This support • 2009 Young Investigator the Foundation to help meritorious is critical to launching the next scientists studying the biological basis generation of researchers who will of neuropsychiatric disorders in their tackle the challenging problem of career trajectory.” how changes in brain development and function lead to mental illness. • 2011 Distinguished Investigator This unique niche protects junior • 2003 & 2000 Independent Investigator investigators during this time when • 1994 & 1990 Young Investigator we are in an ongoing funding crisis for scientific research in general and for mental health research (and treatment) in particular.”

• 2010 Young Investigator

26 ANNUAL REPORT 2017 What Will Your Legacy Be? SUPPORT CUTTING EDGE MENTAL HEALTH RESEARCH AND ADVANCEMENTS

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www.bbrfoundation.org 27 2 0 1 7 w e b i n a r s

Dr. Jeffrey Borenstein hosts the monthly “Meet the Scientist” webinar series where leading brain and behavior researchers discuss their current work on the latest in new technologies, early intervention strategies, and next-generation therapies for mental illness. Each hour-long webinar includes time for researchers to answer questions posed by the online participants.

These popular complimentary webinars offer the general public access to some of the world’s top scientists who present their cutting-edge research that could lead to breakthroughs to alleviate the suffering caused by mental illness. The 2017 season of webinars received more than 22,000 post event views on YouTube. Episodes in the 2017 series are:

January 10 May 9 October 10 Bipolar Disorder: Course and Borderline Personality Disorder: Psychosocial Interventions for Maternal (Possible) Mechanism Diagnosis, Course, and Treatment Depression: Impact on School Age Children Fritz A. Henn, M.D., Ph.D. D. Bradford Reich, M.D. Holly A. Swartz, M.D. Icahn School of Medicine at Mount Sinai McLean Hospital University of Pittsburgh Scientific Council Member 2012 Young Investigator 2006 Young Investigator 2014 Colvin Prizewinner for Outstanding Achievement in Mood Disorders Research June 13 November 14 Toward Rapid-Acting Research Updates: Improving February 14 Treatments for OCD Functioning in Schizophrenia Prefrontal Cortical Circuits in Carolyn Rodriguez, M.D., Ph.D. Stephen R. Marder, M.D. Schizophrenia: Molecular Vulnerabilities, Stanford University, School of Medicine University of California, Los Angeles and Clues for Treatments 2017 Klerman Prize for Exceptional Clinical 2016 Lieber Prizewinner for Outstanding Amy F.T. Arnsten, Ph.D. Research–Honorable Mention Achievement in Schizophrenia Research Yale University School of Medicine 2014, 2009 Young Investigator 2011 Distinguished Investigator Scientific Council Member 2015 Goldman-Rakic Prizewinner July 11 December 12 for The Microbiome and Mental Health Robert Lowell: Courage, 2008 Distinguished Investigator Christopher Lowry, Ph.D. Genius, and Bipolar Disorder 1998 Independent Investigator University of Colorado, Boulder , Ph.D. 2010, 2007 Young Investigator Johns Hopkins University School of Medicine / March 14 Johns Hopkins Hospital Prevention of Depression August 8 2010 Productive Lives Award Michael Berk, Ph.D., MBBCH, MMED, Searching for the Seeds of Psychosis 2000 Falcone Prize for Outstanding FF(Psych)SA, FRANCZP Dolores Malaspina, M.D., M.S., MSPH Achievement in Mood Disorders Research Deakin University School of Medicine NYU Langone Medical Center 2015 Colvin Prizewinner for Outstanding 2007 Distinguished Investigator Achievement in Mood Disorders Research 2001 Independent Investigator 1995, 1993 Young Investigator April 11 Metabolomics and Psychiatric Disease: September 12 NextGen Frontiers in Pathophysiology Finding and Fixing Broken Brain & Treatment Circuits in Depression Lisa A. Pan, M.D. Conor Liston, M.D., Ph.D. University of Pittsburgh School of Medicine Weill Cornell Medical College 2012 Young Investigator 2016 Freedman Prize for Exceptional Basic Research–Honorable Mention 2013 Young Investigator

28 ANNUAL REPORT 2017 Connecting on Getting the Word Social Media Out: Brain & Behavior The Brain & Behavior Research Research Foundation Foundation maintains a strong In the News social media presence in order to communicate and engage January 11, 2017 with all of our constituents and HEALTH DAY 'Stress Ball' in Your Brain May group members. Be Key to Heart Risks

February 15, 2017 SELF Ricki Lake's Ex-Husband Died After Struggling With Bipolar Disorder

May 1, 2017 360k+ Helping Children Cope with a FACEBOOK LIKES Parent’s Death–Letter to the Editor

May 9, 2017 SCIENTIFIC AMERICAN A Shot Against Post-Traumatic Stress Disorder

June 20, 2017 6,000k+ US NEWS AND WORLD REPORT TWITTER FOLLOWERS How to Help Someone Else Who Has Depression

June 26, 2017 FOX NEWS HEALTH PTSD: What Is It and How to Spot It? 400+ November 2017 YOUTUBE VIDEOS INSIDE PHILANTHROPY “Proof of Concept.” How this 348K+ VIDEO VIEWS Funder Backs Young Researchers 668K+ MINUTES WATCHED on Mental Health

December 10, 2017 THE HILL We Need to Do More Than Just Talk About Mental Illness 314% December 20, 1017 WIRED INCREASE IN FOLLOWERS The Best Places to Donate for Last FOR LINKEDIN PAGE IN 2017 Minute Science Gifts

www.bbrfoundation.org 29 2017 RESEARCH GRANTS

SINCE 1987, THE FOUNDATION HAS INDEPENDENT INVESTIGATOR GRANTS AWARDED MORE THAN $380 MILLION • Initiated in 1995. TO FUND MORE THAN 5,500 GRANTS • Support mid-career scientists TO MORE THAN 4,500 LEADING during the critical period between SCIENTISTS AROUND THE WORLD. initiation of research and receipt of sustained funding. Our Grants support a broad range of the • Up to $100,000 for two years. best ideas in brain research. Funding is • More than $81 million funded. focused on four priority areas to better un- derstand and treat mental illness, aiming YOUNG INVESTIGATOR GRANTS toward prevention and ultimately cures: • Initiated in 1987. • Help researchers launch careers in BASIC RESEARCH neuroscience and psychiatry and To understand what happens in the brain gather pilot data to apply for larger to cause mental illness. federal and university grants. • Up to $70,000 for two years. NEW TECHNOLOGIES • More than $257 million funded. To advance or create new ways of studying and understanding the brain. BBRF Grant recipients have gone on to receive more than $3.8 billion in additional DIAGNOSTIC TOOLS/EARLY research funding in next stage NIMH and INTERVENTION NIH grants. To recognize early signs of mental illness and treat as early as possible. No other organization outside of the federal government has funded the NEXT GENERATION THERAPIES number of mental health research To reduce symptoms of mental illness and grants that the Foundation has—or been retrain the brain. responsible for more breakthroughs in the field. DISTINGUISHED INVESTIGATOR GRANTS An independent measure of the success • Initiated in 1988. of our grants is a 2016 RAND Europe • Enable outstanding scientists to pur- analysis of the global mental health sue new, cutting edge ideas with the research funding landscape over the greatest potential for breakthroughs. previous five years. This report found that • $100,000 for one year. we are the top non-government mental • More than $41 million funded. health research funder mentioned in published articles.

30 ANNUAL REPORT 2017 Distinguished Investigators

140 Applications | 17 Grants Approved | $1.7 Million Awarded

The Distinguished Investigator Grants We were impressed by the variety of new provide support for experienced investigators approaches, which could prove helpful or (full professor or equivalent) conducting even transformative, and would supported neurobiological and behavioral research. One- by this seed capital. These include studies year grants of $100,000 each are provided for focusing on the immune system; looking at established scientists pursuing particularly pre-birth events and stressors of all types; innovative project ideas. and examining large important databases for new clues.” Distinguished Investigator Grants fund tal- ented, established scientists with a record of outstanding research accomplishments. These research projects might provide new approach- es to understanding or treating severe mental illness. If successful, the grants could result in later funding from other sources. These grants are among the most competitive in mental health research and demonstrate the power of investigator-initiated research for bringing out new and creative ideas.

“As funds for research from the National Institutes of Health have declined by 20 percent over the past decade, the JACK D. BARCHAS, M.D. Foundation’s Distinguished Investigator Chair, Distinguished Investigator Selection Committee program has become extraordinarily Founding Member of the Foundation’s Scientific Council important for the field and its potential Chair and Barklie McKee Henry Professor of Psychiatry to help severe mental illness. This Weill Cornell Medical College year’s Distinguished Investigators use a remarkable range of methodologies Psychiatrist-in-Chief to sharpen current treatments and Weill Cornell Medical Center, NewYork-Presbyterian Hospital define potential new targets, including and Payne Whitney Clinic previously unstudied or understudied neuroregulators, interactions and circuits, using newer and more precise methods and improved psychosocial approaches.

www.bbrfoundation.org 31 “The uncertainty surrounding future prospects for government funding reinforces the need to support the important work of these scientists, whose research will help us better understand, prevent, diagnose and treat psychiatric illnesses. The generosity of our donors makes these awards possible, and we are grateful to the members of our Scientific Council, who volunteer their time to select the most impactful research.”

—Dr. Jeffrey Borenstein

Independent Investigators 304 Applications | 40 Grants Approved | $3.9 Million Awarded

“This year’s Independent Investigators will This year’s 40 Independent Investigator grant- explore many new and exciting potential ees represent an exciting group of basic and approaches to the therapeutics of serious clinical proposals which should make major mental disorders, and a better understand- contributions to the better understanding ing of their molecular and neuro-biological and treatment of serious psychiatric illness. underpinnings, providing additional new 304 grants were reviewed by 60 members of targets for treatment.” the Scientific Council.

–Dr. Robert Post

Ground-breaking scientists already proven in their field receive the Independent Investigator Grant. These scientists seek to produce experimental results that will put them in a position to initiate major research programs. This support comes at the critical middle period in the investigators’ careers – the phase between the initiation of research and the receipt of sustained funding. ROBERT M. POST, M.D., PH.D. With proven success as highly productive Chair, Independent Investigator scientists, they seek to make clinically relevant Selection Committee advances in the study and treatment of a range Foundation Scientific Council Member of brain and behavior disorders. Head, Bipolar Collaborative Network Professor of Psychiatry Independent Investigator Grants provide each George Washington School of Medicine scientist with $50,000 per year for up to two years to support their work during the critical period between the start of the research and the receipt of sustained funding.

32 ANNUAL REPORT 2017 Young Investigators 864 Applications | 196 Grants Approved | $13.6 Million Awarded

BBRF Young Investigator Grants cover a broad spectrum of mental illnesses and serve as catalysts for additional funding, Independent Investigators providing researchers with “proof of concept” for their work. The Foundation 304 Applications | 40 Grants Approved | $3.9 Million Awarded awarded a total of $13.6 million to its 2017 Young Investigators, strengthening its investment in the most promising ideas to lead advancements in understanding and treating brain and behavior disorders. JUDY M. FORD, PH.D. SUZANNE N. HABER, PH.D. Co-Chair of the Young Investigator Co-Chair of the Young Investigator Young Investigator Grants provide each Grant Selection Committee Grant Selection Committee scientist with $35,000 per year for two Professor, Department of Psychiatry Professor, Department of Pharmacology years totaling $70,000 to enable promising University of California, San Francisco and investigators to either extend research University of Rochester School of Medicine 2003 Independent Investigator fellowship training or begin careers as and Dentistry independent research faculty. Every Young Foundation Scientific Council Member 2011 Distinguished Investigator Investigator gets support and guidance from a scientific mentor designated by the "These grants to young investigators Foundation Scientific Council Member Scientific Council. are the mother’s milk for launching a career in research. They come at a “This year we had an especially “The Young Investigator program time when these young researchers outstanding group of Young represents the intersection of cut- are starting their own programs of Investigator applicants. It’s exciting ting-edge brain and behavior research research, and they need both the to be able to help these young stars and innovation. The grants enable recognition and funding that these YI reach their goals.” outstanding scientists to pursue awards provide. The applicants, and bold new ideas to answer important their proposals this past year [2017], questions or help identify potentially were outstanding. It was often diffi- game-changing targets for treatment. cult to choose the best of the best.” The awards function as seed funding for new directions which would other- wise be highly unlikely.”

—Herbert Pardes, M.D. President of the Scientific Council

www.bbrfoundation.org 33 2017 GRANTS BY ILLNESS

ADDICTION TIFFANY LOVE, PH.D. PANOS ZANOS, PH.D. University of Utah University of Maryland, Baltimore BRIAN A. ANDERSON, PH.D. Young Investigator Grant Young Investigator Grant Texas A&M University Basic Research Next-Generation Therapies Young Investigator Grant Basic Research KATE MCDONNELL-DOWLING, PH.D. –DEFICIT Tufts University HYPERACTIVITY DISORDER KASIA MARIA BIESZCZAD, PH.D. Young Investigator Grant (ADHD) Rutgers University Basic Research Young Investigator Grant MICHELLE MARIE DOWNES, PH.D. Basic Research ELIZABETH GENEVIEVE University College Dublin, Ireland MIETLICKI-BAASE, PH.D. Young Investigator Grant SHAUNNA L. CLARK, PH.D. State University of New York (SUNY), Diagnostic Tools/Early Intervention Virginia Commonwealth University University of Buffalo Young Investigator Grant Young Investigator Grant CLAUDIA AMORIM LOPES, PH.D. Basic Research Basic Research Harvard Medical School Young Investigator Grant LINDSAY MITCHELL DE BIASE, PH.D. HYUNG WOOK NAM, PH.D. New Technologies National Institute on Drug Abuse Louisiana State University Health (NIDA/NIH) Sciences Center SARAH ELIZABETH MEDLAND, Young Investigator Grant Young Investigator Grant PH.D. Basic Research Diagnostic Tools/Early Intervention QIMR Berghofer Medical Research Institute, Australia TRISTEN KIMIKO INAGAKI, PH.D. JAMES MARK OTIS, PH.D. Independent Investigator Grant University of Pittsburgh University of North Carolina at Chapel Hill Basic Research Young Investigator Grant Young Investigator Grant Next-Generation Therapies Basic Research TIMOTHY SPELLMAN, PH.D. Weill Cornell Medical College JEE HYUN KIM, PH.D. MICHAEL P. SADDORIS, PH.D. Young Investigator Grant Florey Neuroscience Institutes, University of University of Colorado, Boulder Basic Research Melbourne, Australia Young Investigator Grant Young Investigator Grant Basic Research ANXIETY Basic Research FAIR MACLAREN VASSOLER, PH.D. GAURAV BEDSE, PH.D. DREW DONOVAN KIRALY, M.D., PH.D. Tufts University Vanderbilt University Medical Center Icahn School of Medicine at Mount Sinai Young Investigator Grant Young Investigator Grant Young Investigator Grant Next-Generation Therapies Next-Generation Therapies Basic Research LEORA YENIKOFF, PH.D. KEVIN THOMAS BEIER, PH.D. XIAOFAN LI, PH.D. City University of New York, Stanford University Icahn School of Medicine at Mount Sinai College of Staten Island Young Investigator Grant Young Investigator Grant Young Investigator Grant Basic Research Basic Research Basic Research

34 ANNUAL REPORT 2017 LAURA BEVILACQUA, M.D., PH.D. JOANNA SPENCER-SEGAL, M.D., PH.D. TERUNAGA NAKAGAWA, M.D., Icahn School of Medicine at Mount Sinai University of Michigan PH.D. Young Investigator Grant Young Investigator Grant Vanderbilt University Next-Generation Therapies Basic Research Independent Investigator Grant Basic Research NADEEKA NIRUPAMA DISSANAYAKA, CHAD MICHAEL SYLVESTER, M.D., PH.D. PH.D. Washington University ANNABELLA PIGNATARO, PH.D. University of Queensland, Australia Young Investigator Grant IRCCS Fondazione Santa Lucia, Italy Young Investigator Grant Basic Research Young Investigator Grant Next-Generation Therapies Basic Research AUTISM / AUTISM SPECTRUM ORIEL FELDMANHALL, PH.D. DISORDER (ASD) RANDALL JEFFREY PLATT, PH.D. University of Zurich Brain Research Institute, Young Investigator Grant KONSTANTINOS AMPATZIS, PH.D. Switzerland Basic Research Karolinska Institute, Sweden Young Investigator Grant Young Investigator Grant Basic Research KATHRYN M. HARPER, PH.D. Basic Research University of North Carolina at Chapel Hill NATHANIEL SNYDER, PH.D., M.P.H. Young Investigator Grant ADRIAAN JOHANNES BOENDER, PH.D. A.J. Drexel Autism Institute Basic Research Emory University Young Investigator Grant Young Investigator Grant Basic Research JENNIFER ANN HONEYCUTT, PH.D. Basic Research Northeastern University JASON J. YI, PH.D. Young Investigator Grant LUKE BURY, PH.D. Washington University School of Medicine Basic Research Case Western Reserve University Young Investigator Grant Young Investigator Grant Basic Research ZHENG JIANG, PH.D. New Technologies Johns Hopkins University EUNICE Y. YUEN, PH.D. Young Investigator Grant CHRISTINA GROSS, PH.D. Yale University Basic Research Cincinnati Children’s Hospital Medical Center, Young Investigator Grant University of Cincinnati Basic Research ANTONIA N. KACZKURKIN, PH.D. Independent Investigator Grant University of Pennsylvania Basic Research BIPOLAR DISORDER Young Investigator Grant Diagnostic Tools/Early Intervention DHANANJAY HUILGOL, PH.D. CYNTHIA V. CALKIN, M.D. Cold Spring Harbor Laboratory Dalhousie University, Canada JOHANNES KOHL, PH.D. Young Investigator Grant Independent Investigator Grant Basic Research Basic Research Young Investigator Grant Basic Research ARKADY KHOUTORSKY, PH.D. STEFANO COMAI, PH.D. McGill University, Canada San Raffaele Vita-Salute University, Italy INDIRA MENDEZ-DAVID, PH.D. Young Investigator Grant Young Investigator Grant Université Paris-Sud 11, France Basic Research Next-Generation Therapies Young Investigator Grant Basic Research HUI-CHEN LU, PH.D. DANIEL HOCHBAUM, PH.D. George Washington University Harvard University JUDITH K. MORGAN, PH.D. Young Investigator Grant Young Investigator Grant University of Pittsburgh Basic Research Basic Research Young Investigator Grant Basic Research GRAINNE M. MCALONAN, M.B.B.S., LIPING HOU, PH.D. PH.D. National Institute of Environmental MICHELLE PELCOVITZ, PH.D. Institute of Psychiatry/King’s College Health Sciences Weill Cornell Medical College London, UK- Young Investigator Grant Young Investigator Grant Independent Investigator Grant Basic Research Next-Generation Therapies Next-Generation Therapies

www.bbrfoundation.org 35 KOKO ISHIZUKA, M.D., PH.D. JULIA BRILL, PH.D. GABRIEL S. DICHTER, PH.D. Johns Hopkins University Johns Hopkins University University of North Carolina at Chapel Hill Independent Investigator Grant Young Investigator Grant Independent Investigator Grant Basic Research Basic Research Basic Research

PO-HSIU KUO, PH.D. DAVID BULKIN, PH.D. SAM EMAMINEJAD, PH.D. National Taiwan University, Taiwan Cornell University University of California, Los Angeles Independent Investigator Grant Young Investigator Grant Young Investigator Grant Basic Research Basic Research Diagnostic Tools/Early Intervention

BRADLEY JOHN MACINTOSH, LAUREN M. BYLSMA, PH.D. LORNA ALICE FARRELLY, PH.D. PH.D. University of Pittsburgh Icahn School of Medicine at Mount Sinai Sunnybrook Health Sciences Centre, Young Investigator Grant Young Investigator Grant University of Toronto, Canada Basic Research Basic Research Independent Investigator Grant Diagnostic Tools/Early Intervention MAITHE ARRUDA CARVALHO, PH.D. TRACY LEE GILMAN, PH.D. University of Toronto, Canada University of Texas Health Science CHRISTIAN GEORG SCHUETZ, M.D., Young Investigator Grant Center at San Antonio PH.D., M.P.H. Basic Research Young Investigator Grant University of British Columbia, Canada Basic Research Independent Investigator Grant BASAR CENIK, M.D., PH.D. Next-Generation Therapies University of Texas Southwestern Medical RONALD GERARDO GARCIA GOMEZ, Center at Dallas M.D., PH.D. BORDERLINE PERSONALITY Young Investigator Grant Brigham and Women’s Hospital and DISORDER Diagnostic Tools/Early Intervention Harvard University Young Investigator Grant KEITH BUSH, PH.D. GLORIA CHOI, PH.D. Next-Generation Therapies University of Arkansas for Medical Sciences Massachusetts Institute of Technology Young Investigator Grant Independent Investigator Grant STEPHANIE MARIE GORKA, PH.D. New Technologies Basic Research University of Illinois at Chicago Young Investigator Grant DEPRESSION ALEXANDRA ELYSE D’AGOSTINO, PH.D. Diagnostic Tools/Early Intervention Stony Brook University School of Medicine FLORENT BARTHAS, PH.D. Young Investigator Grant ELSELINE HOEKZEMA, PH.D. Yale University Next-Generation Therapies Leiden University, Netherlands Young Investigator Grant Young Investigator Grant Basic Research ROBERT DANTZER, DVM, PH.D. Diagnostic Tools/Early Intervention University of Texas MD Anderson ALEXANDRE BONNIN, PH.D. Cancer Center RAQUEL INIESTA, PH.D. University of Southern California Distinguished Investigator King’s College London, UK Independent Investigator Grant Basic Research Young Investigator Grant Basic Research Diagnostic Tools/Early Intervention ELENA GOETZ DAVIS, PH.D. TJEERD WILLEM BOONSTRA, PH.D. Stanford University ORNA ISSLER, PH.D. University of New South Wales, Australia Young Investigator Grant Icahn School of Medicine at Mount Sinai Young Investigator Grant Diagnostic Tools/Early Intervention Young Investigator Grant Next-Generation Therapies Basic Research ZHI-DE DENG, PH.D. PATRICIA A. BRENNAN, PH.D. National Institute of Environmental Health KRISTEN C. JACOBSON, PH.D. Emory University Sciences (NIEHS/NIH) University of Chicago Distinguished Investigator Young Investigator Grant Independent Investigator Grant Diagnostic Tools/Early Intervention Next-Generation Therapies Basic Research

36 ANNUAL REPORT 2017 CHUNG SUB KIM, PH.D. CARMINE MARIA PARIANTE, CRYSTAL VERGARA-LOPEZ, PH.D. University of Texas at Austin M.D., PH.D. The Miriam Hospital, Brown University Young Investigator Grant King’s College London, UK Young Investigator Grant Basic Research Distinguished Investigator Basic Research Basic Research PILYOUNG KIM, PH.D. VERONIKA VILGIS, PH.D. University of Denver DIEGO A. PIZZAGALLI, PH.D. University of California, Davis Independent Investigator Grant McLean Hospital and Harvard University Young Investigator Grant Basic Research Distinguished Investigator Basic Research Basic Research DAPHNE JENNIFER KORCZAK, EATING DISORDER M.D., MSC FLORIAN PLATTNER, PH.D. University of Toronto, Canada University of Texas Southwestern Medical CYNTHIA MARIE BULIK, PH.D. Young Investigator Grant Center at Dallas University of North Carolina at Chapel Hill Basic Research Young Investigator Grant Distinguished Investigator Basic Research Basic Research BENOIT LABONTÉ, PH.D. Laval University, Canada CHRISTOPHE PROULX, PH.D. JASON MATTHEW LAVENDER, PH.D. Young Investigator Grant Laval University, Canada University of California, San Diego Basic Research Young Investigator Grant Young Investigator Grant Basic Research Basic Research JACOPO LAMANNA, PH.D. San Raffaele Vita-Salute University, Italy THOMAS L. RODEBAUGH, PH.D. MENTAL ILLNESS–GENERAL Young Investigator Grant Washington University Basic Research Independent Investigator Grant MEGAN CROW, PH.D. Diagnostic Tools/Early Intervention Cold Spring Harbor Laboratory MATTHEW S. MILAK, M.D. Young Investigator Grant Columbia University FRANCISCO ROMO-NAVA, PH.D. Basic Research Independent Investigator Grant University of Cincinnati Next-Generation Therapies Young Investigator Grant STEVEN WILLEM FLAVELL, PH.D. Next-Generation Therapies Massachusetts Institute of Technology ANDREW H. MILLER, M.D. Young Investigator Grant Emory University JOHN PATRICK RYAN, PH.D. Basic Research Distinguished Investigator University of Pittsburgh Diagnostic Tools/Early Intervention Young Investigator Grant JULIJANA GJORGJIEVA, PH.D. Basic Research Max-Planck Institute of Brain Research, JOSE A. MORON-CONCEPCION, Germany PH.D. SURJO RAPHAEL SOEKADAR, M.D. Young Investigator Grant Washington University University of Tubingen, Germany Basic Research Independent Investigator Grant Young Investigator Grant Basic Research Next-Generation Therapies ELIZABETH J. GLOVER, PH.D. Medical University of South Carolina TALIA NEWCOMBE LERNER, PH.D. JONATHAN P. STANGE, PH.D. Young Investigator Grant Northwestern University University of Illinois at Chicago Basic Research Young Investigator Grant Young Investigator Grant Basic Research Diagnostic Tools/Early Intervention ADAM JOHN HARRINGTON, PH.D. Medical University of South Carolina THOMAS M. OLINO, PH.D. HANNA MARIA VAN LOO, M.D., PH.D. Young Investigator Grant Temple University University of Groningen, Netherlands Basic Research Independent Investigator Grant Young Investigator Grant Basic Research Diagnostic Tools/Early Intervention KOICHI HASHIKAWA, PH.D. New York University School of Medicine Young Investigator Grant Basic Research

www.bbrfoundation.org 37 BRYAN M. HOOKS, PH.D. MARTIN SCHAIN, PH.D. STEVE DAVIDSON, PH.D. University of Pittsburgh Columbia University University of Cincinnati Young Investigator Grant Young Investigator Grant Young Investigator Grant Basic Research New Technologies Basic Research

ELIZABETH DIANA KIRBY, PH.D. ELLIOT H. SMITH, PH.D. ANNEGRET LEA FALKNER, PH.D. State University Columbia University New York University Young Investigator Grant Young Investigator Grant Young Investigator Grant Basic Research Basic Research Basic Research

LEE LOVEJOY, M.D., PH.D. RYAN T. STRACHAN, PH.D. VINCENZO ALESSANDRO GENNARINO, Columbia University University of North Carolina at Chapel Hill PH.D. Young Investigator Grant Young Investigator Grant Baylor College of Medicine Basic Research Next-Generation Therapies Young Investigator Grant Basic Research MIKAEL LARS LUNDQVIST, PH.D. RODRIGO SUAREZ, PH.D. Massachusetts Institute of Technology University of Queensland, Australia LAURA GERMINE, PH.D. Young Investigator Grant Young Investigator Grant McLean Hospital/Harvard University Basic Research Basic Research Young Investigator Grant Basic Research THOMAS HATTON MCCOY, M.D. ELSA SUBERBIELLE, D.V.M, PH.D. Massachusetts General Hospital/ INSERM, France OLIVIER GSCHWEND, PH.D. Harvard University Young Investigator Grant New York University Young Investigator Grant Basic Research Young Investigator Grant Diagnostic Tools/Early Intervention Basic Research CINZIA VICIDOMINI, PH.D. ANDREA MELE, PH.D. Massachusetts General Hospital, SARAH M. HAIGH, PH.D. Universita’ di Roma La Sapienza, Italy Harvard University University of Pittsburgh Independent Investigator Grant Young Investigator Grant Young Investigator Grant Basic Research Basic Research Basic Research

ERIC MATTHEW MORROW, KAREN L. WHITEMAN, PH.D., MSW KEREN HAROUSH, PH.D. M.D., PH.D. Dartmouth Medical School, Stanford University Brown University Dartmouth College Young Investigator Grant Independent Investigator Grant Young Investigator Grant Basic Research Basic Research Next-Generation Therapies MATTHEW CARL HEARING, PH.D. FRANCESCA MARIA PIA ANDREA YOUNG, PH.D. Marquette University NOTARANGELO, PH.D. Johns Hopkins University Young Investigator Grant University of Maryland, Baltimore Young Investigator Grant Basic Research Young Investigator Grant Diagnostic Tools/Early Intervention Basic Research SARAH RACHEL HEILBRONNER, PH.D. MENTAL ILLNESS–MULTIPLE University of Rochester MARCO ONORATI, PH.D. DISORDERS Young Investigator Grant University of Italy, Pisa, Italy Basic Research Young Investigator Grant BRENT WILLIAM ASRICAN, PH.D. Basic Research University of North Carolina at Chapel Hill LAURA MARIANNE HUCKINS, PH.D. Young Investigator Grant Icahn School of Medicine at Mount Sinai IRVING MICHAEL RETI, M.B.B.S. Basic Research Young Investigator Grant Johns Hopkins University Basic Research Independent Investigator Grant ELISABETH B. BINDER, M.D., PH.D. Next-Generation Therapies Max-Planck Institute of Psychiatry, Germany SOONJO HWANG, M.D. Distinguished Investigator University of Nebraska Medical Center Basic Research Young Investigator Grant Next-Generation Therapies

38 ANNUAL REPORT 2017 LUKE WILLIAMSON HYDE, PH.D. NATHAN OKERLUND, PH.D. JAMES FITZHUGH STURGILL, PH.D. University of Michigan University of Utah Cold Spring Harbor Laboratory Young Investigator Grant Young Investigator Grant Young Investigator Grant Basic Research Basic Research Basic Research

EMILY G. JACOBS, PH.D. CARLOS J. A. B. PANTOJA, M.D., PH.D. LOURDES FAÑANÁS SAURA, University of California, Santa Barbara Max Planck Institute of Neurobiology, M.D., PH.D. Young Investigator Grant Germany University of Barcelona, Spain Basic Research Young Investigator Grant Distinguished Investigator Basic Research Diagnostic Tools/Early Intervention SUN-HONG KIM, PH.D. Johns Hopkins University KRISTEN ELIZABETH PLEIL, PH.D. STEVEN A. SIEGELBAUM, PH.D. Young Investigator Grant Weill Cornell Medical College Columbia University Basic Research Young Investigator Grant Distinguished Investigator Basic Research Basic Research EMMA EILEEN MARY KNOWLES, PH.D. Yale University GIOVANNI PROVENZANO, PH.D. ZHIBING TAN, M.D., PH.D. Young Investigator Grant University of Trento, Italy Augusta VA Medical Center, Diagnostic Tools/Early Intervention Young Investigator Grant Georgia Health Sciences University Basic Research Young Investigator Grant DAVID R. KOPALA-SIBLEY, PH.D. Basic Research Stony Brook University School of Medicine CANDACE MARIE RAIO, PH.D. Young Investigator Grant New York University JEROME H. TAYLOR, M.D. Diagnostic Tools/Early Intervention Young Investigator Grant Yale University Basic Research Young Investigator Grant ROMAIN LIGNEUL, PH.D. Next-Generation Therapies Fundação Champalimaud, Portugal PATRICK ELDREDGE ROTHWELL, PH.D. Young Investigator Grant University of Minnesota PAUL MATTHEW THOMPSON, PH.D. Basic Research Young Investigator Grant University of Southern California Next-Generation Therapies Distinguished Investigator QING-SONG LIU, PH.D. Basic Research National Institutes of Health ATSUSHI SAITO, M.D., PH.D. Young Investigator Grant Johns Hopkins University JILLIAN LEE WIGGINS, PH.D. Basic Research Young Investigator Grant San Diego State University Basic Research Young Investigator Grant CRISTINA MARQUEZ, PH.D. Diagnostic Tools/Early Intervention Instituto de Neurociencias de Alicante, CODY A. SICILIANO, PH.D. Universidad Miguel Hernandez, Spain Massachusetts Institute of Technology RALF DIETER WIMMER, PH.D. Young Investigator Grant Young Investigator Grant New York University Basic Research Basic Research Young Investigator Grant Basic Research NATALIE MATOSIN, PH.D. TANYA SIPPY, M.D., PH.D. Max-Planck Institute of Psychiatry, Germany New York University SUSAN K. WOOD, PH.D. Young Investigator Grant Young Investigator Grant University of South Carolina Basic Research Basic Research Young Investigator Grant Basic Research CHRISTIAN MEISEL, M.D.,PH.D. KATHARINE RACHEL SMITH, PH.D. National Institute of Mental Health University of Colorado, Denver OBSESSIVE–COMPULSIVE Young Investigator Grant Young Investigator Grant DISORDER (OCD) Diagnostic Tools/Early Intervention Basic Research THOMAS V. FERNANDEZ, M.D. JUAN MENA-SEGOVIA, M.D.,PH.D. MARTA ELAINE SODEN, PH.D. Connecticut Mental Health Center, Rutgers University University of Washington Yale University Young Investigator Grant Young Investigator Grant Young Investigator Grant Basic Research Basic Research Basic Research

www.bbrfoundation.org 39 ODED KLAVIR, PH.D. JENNIFER R. FANNING, PH.D. KERRY J. RESSLER, M.D., PH.D. University of Haifa, Israel University of Chicago McLean Hospital and Harvard University Young Investigator Grant Young Investigator Grant Distinguished Investigator Basic Research Basic Research Basic Research

PSYCHOSIS DAMION GRASSO, PH.D. PRERANA SHRESTHA, PH.D. University of Connecticut and New York University CLAUDIA M. HAASE, PH.D. Hartford Hospital Young Investigator Grant Northwestern University Young Investigator Grant Basic Research Young Investigator Grant Basic Research Basic Research BENJAMIN SUAREZ-JIMENEZ, PH.D. BENJAMIN FRIEDRICH GREWE, PH.D. Research Foundation for Mental Hygiene, Inc./ MANREENA KAUR, PH.D. Brain Research Institute of the NYSPI, Columbia University Monash University, Australia University of Zurich, Switzerland Young Investigator Grant Young Investigator Grant Young Investigator Grant New Technologies Next-Generation Therapies Basic Research JENNIFER BROOKE TREWEEK, PH.D. DEEPAK KUMAR SARPAL, M.D. KATHERINA HAUNER, PH.D. California Institute of Technology University of Pittsburgh Northwestern University Young Investigator Grant Young Investigator Grant Young Investigator Grant Basic Research Basic Research Next-Generation Therapies SCHIZOPHRENIA GISELA SUGRANYES, M.D., PH.D. LIAT HELPMAN, PH.D. Institut D’investigacions Biomèdiques August Tel Aviv Sourasky Medical Center, TRACY ANN BARBOUR, M.D. Pi I Sunyer, Spain Tel Aviv University, Israel Massachusetts General Hospital Young Investigator Grant Young Investigator Grant Young Investigator Grant Basic Research Basic Research Basic Research

LAURI TUOMINEN, M.D., PH.D. THU HUYNH, PH.D. MERA SUN BARR, PH.D. Massachusetts General Hospital, Weill Cornell Medical College Centre for Addiction and Mental Health Harvard University Young Investigator Grant at the University of Toronto, Canada Young Investigator Grant Basic Research Young Investigator Grant Basic Research Diagnostic Tools/Early Intervention JONATHAN LEVY, PH.D. POST–TRAUMATIC STRESS Interdisciplinary Center, CLARE L. BEASLEY, PH.D. DISORDER (PTSD) Herzliya (IDC), Israel University of British Columbia, Canada Young Investigator Grant Independent Investigator Grant ROEE ADMON, PH.D. Basic Research Diagnostic Tools/Early Intervention University of Haifa, Israel Young Investigator Grant STEPHEN MAREN, PH.D. HADAR BEN-YOAV, PH.D. Basic Research Texas A&M University Ben-Gurion University of the Negev, Israel Distinguished Investigator Young Investigator Grant TIMOTHY WILLIAM BREDY, Basic Research New Technologies PH.D. University of Queensland, Australia PIA-KELSEY O’NEILL, PH.D. JAMES ANDREW BOURNE, PH.D. Independent Investigator Grant Columbia University Monash University, Australia Basic Research Young Investigator Grant Independent Investigator Grant Basic Research Basic Research JAMES DOUGLAS BREMNER, M.D. Emory University ABHA KARKI RAJBHANDARI, PH.D. MADDALENA DELMA CAIATI, Distinguished Investigator University of California, Los Angeles M.D., PH.D. Next-Generation Therapies Young Investigator Grant Harvard University Basic Research Young Investigator Grant Basic Research

40 ANNUAL REPORT 2017 SARAH E. CANETTA, PH.D. COLIN SHAUN HAWCO, PH.D. VIJAY ANAND MITTAL, PH.D. Columbia University Centre for Addiction and Mental Health, Northwestern University Young Investigator Grant University of Toronto, Canada Independent Investigator Grant Basic Research Young Investigator Grant Next-Generation Therapies Basic Research MOLLY ERICKSON, PH.D. DEREK WILLIAM MORRIS, PH.D. Rutgers University GABRIEL E. HOFFMAN, PH.D. National University of Ireland, Young Investigator Grant Icahn School of Medicine at Mount Sinai Galway, Ireland Next-Generation Therapies Young Investigator Grant Independent Investigator Grant Basic Research Basic Research MAR FATJO-VILAS, PH.D. FIDMAG Research Foundation, Spain LIANG-TIEN HSIEH, PH.D. LESLIE GISELLE NUCIFORA, PH.D. Young Investigator Grant University of California, Davis Medical Center Johns Hopkins University Basic Research Young Investigator Grant Young Investigator Grant Basic Research Basic Research KATIE FERGUSON, PH.D. Yale University SIMONA KELLER, PH.D. SHAUNA LEE PARKES, PH.D. Young Investigator Grant University of Naples Federico II, Italy Universite Bordeaux II, France Basic Research Young Investigator Grant Young Investigator Grant Basic Research Basic Research TOM P. FRANKEN, M.D., PH.D. Salk Institute for Biological Studies JERILLYN S. KENT, PH.D. SERGIU P. PASCA, M.D. Young Investigator Grant University of Minnesota Stanford University Basic Research Young Investigator Grant Independent Investigator Grant Basic Research Basic Research JOSEPH A. GOGOS, M.D., PH.D. Columbia University TAKASHI KITAMURA, PH.D. QUENTIN PERRENOUD, PH.D. Distinguished Investigator University of Texas Southwestern Medical Yale University Basic Research Center at Dallas Young Investigator Grant Young Investigator Grant Basic Research ALESSANDRO GOZZI, PH.D. Basic Research Italian Institute of Technology, Italy REBECCA ANN PISKOROWSKI, Independent Investigator Grant ELLEN EUN-OK LEE, M.D. PH.D. Basic Research University of California, San Diego French National Institute of Health Young Investigator Grant and Medical Research, INSERM, France CHRISTOPHER MARTIN HAMMELL, Basic Research Independent Investigator Grant PH.D. Basic Research Cold Spring Harbor Laboratory ROBERT T. MALISON, M.D. Independent Investigator Grant Yale University School of Medicine/ BENJAMIN C. REINER, PH.D. Basic Research Yale University University of Pennsylvania Distinguished Investigator Young Investigator Grant EILIS HANNON, PH.D. Basic Research Basic Research University of Exeter, U.K. Young Investigator Grant SIMON MCCARTHY-JONES, LAURA M. ROWLAND, PH.D. Basic Research PH.D. University of Maryland School of Medicine Trinity College, Dublin, Ireland Independent Investigator Grant SAMI HASSAN, PH.D. Independent Investigator Grant Next-Generation Therapies Columbia University Next-Generation Therapies Young Investigator Grant AMAR SAHAY, PH.D. Basic Research ODED MEIRON, PH.D. Massachusetts General Hospital Sarah Herzog Memorial Hospital, Independent Investigator Grant Hebrew University, Israel Basic Research Independent Investigator Grant Next-Generation Therapies

www.bbrfoundation.org 41 CHRISTIN SCHIFANI, PH.D. ELISABET VILELLA, PH.D. Centre of Addiction and Mental Health, Institute Pre Mata (IISPV-HPU), Spain University of Toronto, Canada Independent Investigator Grant Young Investigator Grant Basic Research Diagnostic Tools/Early Intervention HENRIK WALTER, M.D., PH.D. JOSEPH JAMES SHAFFER, PH.D. Charité Universitätsmedizin Berlin, Germany University of Iowa Distinguished Investigator Young Investigator Grant Basic Research Next-Generation Therapies JAMES T.R. WALTERS, M.D., PATRICK DAVID SKOSNIK, PH.D. PH.D. Yale University Cardiff University, United Kingdom Independent Investigator Grant Independent Investigator Grant Basic Research Basic Research

DEEPAK PRAKASH SRIVASTAVA, JARI G. WILLING, PH.D. PH.D. University of Illinois at Urbana-Champaign Institute of Psychiatry/King’s College Young Investigator Grant London, UK-England Basic Research Independent Investigator Grant Basic Research SUICIDE PREVENTION

BRYAN ANDREW STRANGE, HENRY WILLIAM CHASE, PH.D. M.B.B.S., PH.D. University of Pittsburgh Technical University of Madrid, Spain Young Investigator Grant Independent Investigator Grant Next-Generation Therapies Next-Generation Therapies SAKINA RIZVI, PH.D. PING SU, PH.D. University of Toronto, Canada Centre for Addiction and Mental Health, Young Investigator Grant University of Toronto, Canada Basic Research Young Investigator Grant Next-Generation Therapies OTHER DISORDERS [RETT SYNDROME] ROBERT ALAN SWEET, M.D. University of Pittsburgh ANNIE VOGEL CIERNIA, PH.D. Distinguished Investigator University of California, Davis Basic Research Young Investigator Grant Basic Research DUJE TADIN, PH.D. University of Rochester RALF S. SCHMID, PH.D. Independent Investigator Grant University of North Carolina at Chapel Hill Basic Research Young Investigator Grant Next-Generation Therapies HALENE TOBIAS, M.D., PH.D. Icahn School of Medicine at Mount Sinai Young Investigator Grant Basic Research

JOHN B. TOROUS, M.D. Beth Israel Deaconess Medical Center, Harvard University Young Investigator Grant Diagnostic Tools/Early Intervention

42 ANNUAL REPORT 2017 2017 FOUNDATION EVENTS

Photo Credits: Chad David Kraus

www.bbrfoundation.org 43 International Awards Dinner New York, October 27, 2017

The Foundation celebrated its 30th Annual Sans Frontières (MSF), for its visionary Tadafumi Kato, M.D., Ph.D. International Awards Dinner at The Pierre. and pioneering work providing urgent and RIKEN Brain Science Institute, Japan The evening included the presentation often neglected mental health care to of the Pardes Humanitarian Prize in people facing crises across the globe. Mary L. Phillips, M.D., M.D. (Cantab) Mental Health and the awarding of the University of Pittsburgh, Foundation’s Outstanding Achievement Honorary Tribute: Western Psychiatric Institute and Clinic Awards to nine exceptional scientists Constance E. Lieber for their significant contributions to the For her extraordinary and enduring RUANE PRIZE FOR OUTSTANDING advancement of our understanding legacy of generosity, brilliance and ACHIEVEMENT IN CHILD AND of schizophrenia, mood disorders, compassion, which has inspired others ADOLESCENT PSYCHIATRIC RESEARCH child and adolescent psychiatry and to improve the lives of people suffereing Nathan A. Fox, Ph.D. cognitive neuroscience. from mental illness. The University of Maryland, College Park

PARDES HUMANITARIAN PRIZE LIEBER PRIZE FOR Charles A. Nelson III, Ph.D. IN MENTAL HEALTH OUTSTANDING ACHIEVEMENT Harvard Medical School & The Pardes Humanitarian Prize in Mental IN SCHIZOPHRENIA RESEARCH Boston’s Children’s Hospital Health was established in 2014 and is John M. Davis, M.D. awarded annually to recognize individuals University of Illinois at Chicago Charles H. Zeanah, Jr., M.D. or organizations that are making a pro- Tulane University School of Medicine found and lasting impact in advancing MALTZ PRIZE FOR the understanding of mental health and INNOVATIVE & PROMISING GOLDMAN-RAKIC PRIZE FOR improving the lives of people suffering SCHIZOPHRENIA RESEARCH OUTSTANDING ACHIEVEMENT from mental illness. Deanna L. Kelly, Pharm.D., BCPP IN COGNITIVE NEUROSCIENCE University of Maryland School of Medicine Trevor W. Robbins, Ph.D. Honoree: , UK Doctors Without Borders/Médecins COLVIN PRIZE FOR Sans Frontières (MSF) OUTSTANDING ACHIEVEMENT The 2017 Pardes Humanitarian Prize in IN MOOD DISORDERS RESEARCH Mental Health was awarded to the inter- Hilary P. Blumberg, M.D. national medical humanitarian organiza- Yale School of Medicine tion Doctors Without Borders/Médecins

Dr. Jeffrey Borenstein, Stephen Lieber, Dr. Herbert Pardes, and Jason Cone, Executive Director MSF

44 ANNUAL REPORT 2017 Dinner Committee Anne and Ronald Abramson Carol Atkinson Patricia and Eric Bam Janet and Donald Boardman Raymonde and J. Anthony Boeckh Jeffrey Borenstein, M.D. Susan Lasker Brody Suzanne and John Golden Bonnie and Alan Hammerschlag Marla Press and Ken Harrison Kathy and John Hollister Judith and Thomas Iovino Stephen A. Lieber Carole and Harvey Mallement Tamar and Milton Maltz Miriam Katowitz and Arthur Radin, CPA Léa Dartevelle and Marc R. Rappaport Virginia and Mark Silver, M.D. Please join us at the Brain & Behavior Research Foundation’s th Kenneth Sonnenfeld, Ph.D, J.D. 30 Anniversary Celebration Barbara and John Streicker Barbara Toll Frances and Robert Weisman, Esq. INTERNATIONAL AWARDS DINNER

th 90 Park Avenue, New York, NY 10016 | 646.681.4888 | bbrfoundation.org FRIDAY, OCTOBER 27 The Pierre The Brain & Behavior Research Foundation is committed to alleviating the suffering caused by 2 East 61st Street, mental illness by awarding grants that will lead to advances and breakthroughs in scientific research. 2017 6:30pm Cocktails | 7:30pm Dinner

The evening includes a presentation of the Pardes Humanitarian Prize in Mental Health and the Outstanding Achievement Prizewinners

Dr. Herbert Pardes and Dr. Max Gomez Dr. Jeffrey Borenstein and Dr. Deanna Kelly

Dr. Charles Zeanah, Jr., Dr. Jeffrey Borenstein, Dr. Charles Nelson, III and Dr. Nathan Fox Dr. Norman Sartorius and Dr. William Carpenter

www.bbrfoundation.org 45 International Mental Health Research Symposium New York, October 27, 2017

The 29th International Mental Health THE BRAIN CIRCUITRY OF BIPOLAR Research Symposium featured a keynote DISORDER: A VIEW FROM BRAIN presentation by Dr. Herbert Pardes, SCANNING RESEARCH the President of the Foundation’s Hilary P. Blumberg, M.D. Scientific Council. The day also included scientific presentations by the eight 2017 MECHANISMS OF MOOD DISORDER Outstanding Achievement Prizewinners IN THE HUMAN BRAIN: NEURAL and two exceptionally promising Young TARGETS FOR NEW TREATMENTS Investigator Grantees and was held at Mary L. Phillips, M.D., M.D. (Cantab) The Kaufman Music Center. RECOVERY FROM SEVERE Presentations Included: PSYCHOSOCIAL DEPRIVATION Nathan A. Fox, Ph.D. Keynote Speaker: Charles A. Nelson III, Ph.D. ARE THERE BREAKTHROUGH Charles H. Zeanah, Jr., M.D. OPPORTUNITIES FOR MENTAL HEALTH? Herbert Pardes, M.D. ADDICTION AS BRAIN DISORDER OF SELF-CONTROL THE PREVENTION OF Trevor W. Robbins, Ph.D. RELAPSE WITH MEDICATION: A STATISTICAL PERSPECTIVE HARNESSING THE MICROBIOTA- John M. Davis, M.D. GUT-BRAIN AXIS DURING PREGNANCY TO IMPROVE MOTHER AND CHILD’S TOWARD PERSONALIZED MEDICINE HEALTH IN SCHIZOPHRENIA: CLINICAL TRIALS Mary C. Kimmel, M.D. TARGETING SPECIFIC BIOMARKERS AND PATIENT POPULATIONS BRAIN DEVELOPMENT AND Deanna L. Kelly, Pharm.D., BCPP THE IMMUNE SYSTEM: THE BASIC SCIENCE OF STRESS Anna V. Molofsky, M.D., Ph.D.

Dr. Robert Hirschfeld Dr. Hilary Blumberg Dr. Mary Phillips

46 ANNUAL REPORT 2017 Dr. Herbert Pardes Dr. Trevor Robbins

Dr. Deanna Kelly Dr. Charles Zeanah, Jr., Dr. Charles Dr. John Davis Nelson, III and Dr. Nathan Fox 2017 INTERNATIONAL MENTAL HEALTH RESEARCH SYMPOSIUM

Friday, October 27, 2017 9:00am–4:30pm Kaufman Music Center 129 West 67th Street New York, NY 10023

Dr. Mary Kimmel Dr. Anna Molofsky

www.bbrfoundation.org 47 Klerman & Freedman Awards Dinner New York, July 28, 2017

This very special evening celebrated the FREEDMAN PRIZEWINNER 30th anniversary of the Brain & Behavior Ilana B. Witten, Ph.D., of Princeton Research Foundation and honored the University for her work on “Dopamine, members of our Scientific Council for , and Schizophrenia: their service. Dissecting Spatiotemporal Dynamics.”

Six Young Investigator Grantees HONORABLE MENTIONS were honored for their outstanding Marcelo de Oliveira Dietrich, contributions to mental health research M.D., Ph.D., of the Yale School of at The Metropolitan Club in New York Medicine for his grant project titled City. These researchers were chosen by a “Interplay Between Sustained Activation of committee of the Foundation’s Scientific AgRP Neurons and Dopamine Signaling in Council for their exceptional BBRF grant the Etiology of Anorexia Nervosa.” projects in terms of insight and potential new approaches to the treatment of Elise B. Robinson, Sc.D., M.P.H., mental illness. of the Harvard T.H. Chan School of Public Health for her grant project, “Genotype Each investigator has demonstrated to Phenotype Association in Autism exceptional promise in the pursuit of Spectrum Disorders.” deeper understanding of the human brain to ultimately result in cures through research. KLERMAN & KLERMAN PRIZEWINNER FREEDMAN Jennifer C. Felger, Ph.D. of Emory AWARDS University School of Medicine for her work on “The Neurocircuitry of Inflammation- DINNER Induced Anhedonia in Depression.” Celebrating Our 30th Anniversary HONORABLE MENTIONS & Honoring Our Danai Dima, Ph.D., of City, University Scientific Council of London and Kings College London for her grant research project, “An Integrative FRIDAY, JULY 28, 2017 Genomics and Imaging Approach to Identify METROPOLITAN CLUB NEW YORK Resilient Mechanisms for Bipolar Disorder.”

Carolyn Rodriguez, M.D., Ph.D. of Stanford University for her grant project, “Pilot Study of the NMDAR Modulator Rapastinel (formerly GLYX-13) in Obsessive-Compulsive Disorder.”

Klerman Prizewinner Dr. Jennifer Felger and Dr. Herbert Pardes

48 ANNUAL REPORT 2017 Dr. Myrna Weissman and Dr. Herbert Pardes and Freedman Prizewinner Dr. Ilana Witten Dr. Anissa-Abi Dargham

Dr. Carolyn Rodriguez, Klerman Dr. Danai Dima, Klerman Prize Honorable Dr. Marcelo de Oliveira Dietrich, Prize Honorable Mention and Mention and Dr. Herbert Pardes Freedman Prize Honorable Mention Dr. Herbert Pardes and Dr. Herbert Pardes

Dr. and Dr. Solomon Snyder Dr. Amy Arnsten, Dr. Helen Mayberg, and Dr. Daniel Weinberger

www.bbrfoundation.org 49 Women Breaking the Silence About Mental Illness Luncheon New York, April 15, 2017

Our third Women’s Luncheon featured Ellen Levine as Moderator our moderator who led a wide-ranging conversation with Ellen Levine, Editor and Innovator, Hearst Magazines pioneering mental health researchers Dolores Malaspina, M.D. (schizophrenia) and Myrna Weissman, Ph.D. (mood and anxiety Speakers disorders) before a sold-out audience of 300 at the Metropolitan Dolores Malaspina, M.D., M.S., MSPH Club in Manhattan. The event, co-chaired by board members Director, Psychosis Program Suzanne Golden, Carole Mallement and Barbara Streicker, raised Icahn School of Medicine at Mount Sinai more than $250,000. Myrna Weissman, Ph.D. Our Women’s Luncheon is designed to pay tribute to those Diane Goldman Kemper Family Professor women (often the primary caregivers) who are willing to speak of Epidemiology in Psychiatry candidly and personally about mental illness and how they inspire Columbia University College of Physicians & Surgeons others to speak out against the stigma surrounding brain and behavior disorders.

A Conversation Between ellen levine, dr.dolores malaspina & dr.myrna weissman Dr. Dolores Malaspina, Dr. Myrna Weissman and Ellen Levine

Metropolitan Club New York April 25, 2017

Dr. Jeffrey Borenstein, Barbara Streicker, Dr. Myrna Weissman, Ellen Levine, Carole Mallement, Dr. Dolores Malaspina and Suzanne Golden

50 ANNUAL REPORT 2017 BECOME A RESEARCH PARTNER

UNITING DONORS WITH SCIENTISTS “My brother first exhibited symptoms of schizophrenia in 1960 at age 17. When we were able to support psychiatric research as a family, we found the Brain & Behavior Research Foundation. I became a Research Partner because the satisfaction of enabling a Young Investigator’s work to unlock the pathways to understanding the sources of psychiatric illness is incredibly satisfying. Now I support three Young Investigators each year. My brother knew that whatever science discovered, it would be too late for him, but he wanted to know that others could avoid the illness that had ruined his life. I donate to honor his wish.” —Barbara Toll, Foundation Board Member

BENEFITS OF BECOMING A RESEARCH PARTNER • Personally select & sponsor a scientist conducting research that is important to you and your family • Receive annual scientific updates and progress reports • Interact one-on-one with your scientist partner Barbara Toll, Research Partner through email, phone or a laboratory visit

Please contact us at 800-829-8289

Email [email protected]. Visit bbrfoundation.org/researchpartner.

www.bbrfoundation.org 51 WHY GIVE TO THE BRAIN & BEHAVIOR RESEARCH FOUNDATION

WHEN YOU SUPPORT THE BRAIN & BEHAVIOR RESEARCH FOUNDATION YOU ARE:

• Impacting the future and moving the needle forward “When my brother and I decided to donate to what was in the search for better treatments and cures for then NARSAD, he said ‘I know that research probably mental illness. won’t find anything in time to help me, but it could help someone else’. I have never forgotten that I am • Driving commitment forward to change and to increase involved in the Brain & Behavior Research Foundation the understanding of mental illness. for my brother, and to alleviate future suffering for both patients and families.” • Keeping the pipeline of scientific research flourishing with sustained momentum in the field. —Barbara Toll, BBRF Board Member

BBRF donors know that scientific progress has been made, “I am consistently impressed and amazed how BBRF but much more work is needed to help alleviate the suffering has advanced the intersection between world-class caused by mental illness. science and the world of those whose lives are touched by serious mental illness. For those who are Thanks to our generous donors, the Brain & Behavior afflicted with mental illness and those who support Research Foundation will continue to fund the development the cause for progress towards a cure, I salute this of new treatments, cures and methods of prevention for wonderful organization.” these devastating conditions. Please know that your support has an impact. —Don Boardman, BBRF Board Member

“The John and Polly Sparks Foundation strives to “I chose to fundraise for BBRF because the research advance mental health by helping individuals and that is conducted covers so many illnesses that either families who face challenges, improving the quality of you or someone close to you has been afflicted with– care and supporting research. We are very fortunate and 100% of donation goes towards research. Nothing to have as our research partner the Brain and Behavior can compare to what individuals go through on a daily Research Foundation. It is wonderful to know that basis battling different illnesses but training for some- 100% of our contributions support cutting edge thing so grueling as an ironman triathlon and preparing research selected by world renowned scientists.” yourself for a 14 hour day is not easy. Knowing that I was trying to help raise money and thinking of all the —Richard Hallock, Distribution Committee of the John people that really suffer pushed me further.” and Polly Sparks Foundation, BBRF Donor —Darren DelPriore, Team Up for Research Fundraiser, Montvale, NJ

52 ANNUAL REPORT 2017 DONORS

Thank You The generous support of our donors is what allows us to celebrate 30 years of remarkable research achievements. We’re honored by the trust you, our donors, have placed in the Brain & Behavior Research Foundation to fund the development of new treatments, cures, and methods of prevention to help alleviate the suffering caused by mental illness.

www.bbrfoundation.org 53 RESEARCH PARTNERS Independent Investigator RONALD AND KATHY CHANDONAIS Matthew S. Milak, M.D. Patrick A. Coffer Investigator JAN ABRAMS Columbia University Jan Abrams Investigators Young Investigator Independent Investigator Benjamin C. Reiner, Ph.D. Young Investigator Larry S. Zweifel, Ph.D. University of Pennsylvania Marta Biagioli, Ph.D. University of Washington University of Trento MR. AND MRS. EVERETT DESCHNER ATHERTON FOUNDATION Katherine Deschner Family Investigator Young Investigator Atherton Investigator Eunice Y. Yuen, M.D., Ph.D. Young Investigator Yale University Young Investigator Leah H. Somerville, Ph.D. Kaustubh Satyendra Supekar, Ph.D. Harvard University ANNE AND RON ABRAMSON Stanford University Abramson Family Foundation Investigator ESSEL FOUNDATION DIANA AND DAN ATTIAS Essel Investigators Young Investigator Attias Family Foundation Investigators Sharmin Ghaznavi, M.D., Ph.D. Independent Investigator Massachusetts General Hospital Young Investigator Wen-Jun Gao, M.D., Ph.D. Harvard University Allyson Kimberly Friedman, Ph.D. Drexel University College of Medicine Research Foundation of The City University ANONYMOUS of New York on behalf of Hunter College Independent Investigator Haddie Investigator Kirsty Millar, Ph.D. Young Investigator University of Edinburgh Independent Investigator Mira Alexandra Jakovcevski, Ph.D. Simon McCarthy-Jones, Ph.D. Max-Planck Institute of Psychiatry Young Investigator Trinity College, Dublin Max-Planck Society/Max Planck Institutes Wesley Brian Asher, Ph.D. Research Foundation for Mental Hygiene, Inc./ ANONYMOUS BARBARA AND MICHAEL BASS NYSPI Young Investigator Barbara and Michael Bass Investigator Columbia University Desmond Jay Oathes, Ph.D. University of Pennsylvania Young Investigator Young Investigator Sarah E. Canetta, Ph.D. Santhosh Girirajan, M.B.B.S., Ph.D. ANONYMOUS Research Foundation for Mental Hygiene, Pennsylvania State University Young Investigator Inc./NYSPI Gustavo Adolfo Angarita, M.D. Columbia University Young Investigator Yale University Markita Patricia Landry, Ph.D. JANET AND DONALD BOARDMAN University of California, Berkeley Young Investigator Janet and Donald Boardman Investigator Sjoerd Jehannes Finnema, Ph.D., Young Investigator Pharm.D. Young Investigator Jacqueline Morris, Ph.D. Yale University Jessica A. Bernard, Ph.D. University of Pennsylvania Texas A&M University ANONYMOUS FAMILIES FOR BORDERLINE Zorich Family Investigator DAVID J. BREUER MEMORIAL PERSONALITY DISORDER RESEARCH David J. Breuer Memorial Investigators Families For Borderline Personality Distinguished Investigator Disorder Research Investigators Marina R. Picciotto, Ph.D. Young Investigator Yale University Viviane Labrie, Ph.D. Young Investigator Van Andel Research Institute Emily B. Ansell, Ph.D. ANONYMOUS Syracuse University Zorich Family Investigators Young Investigator Stephan Ripke, M.D., Ph.D. Young Investigator Charité-University Medicine Berlin Keith Bush, Ph.D. Freie Universitat Berlin University of Arkansas for Medical Sciences

54 ANNUAL REPORT 2017 Young Investigator INTERNATIONAL BIPOLAR Independent Investigator Hyun-Jae Pi, Ph.D. FOUNDATION (IBF) Stanislav S. Zakharenko, M.D., Ph.D. Brandeis University International Bipolar Foundation (IBF) St. Jude Children’s Research Hospital Investigator SUZANNE AND JOHN GOLDEN Young Investigator Suzanne and John Golden Investigator Young Investigator Marta Ribases, Ph.D. Rupali Srivastava, Ph.D. Vall d’Hebron Research Institute VHIR Independent Investigator Johns Hopkins University Peng Jin, Ph.D. Young Investigator Emory University THE RONA JAFFE FOUNDATION Simon Trent, Ph.D. The Rona Jaffe Foundation Investigator Cardiff University GOLDEN RULE FAMILY FOUNDATION Golden Rule Family Foundation Young Investigator Young Investigator Investigator June Gruber, Ph.D. Nan Yang, Ph.D. University of Colorado, Boulder Stanford University Young Investigator Chun Hay Alex Kwan, Ph.D. KAPLEN FOUNDATION MILTON & TAMAR MALTZ Yale University Michael F. Kaplen Investigator FAMILY FOUNDATION Maltz Investigators BONNIE AND ALAN HAMMERSCHLAG Young Investigator PHILANTHROPIC FUND Mariana Pereira, Ph.D. Young Investigator Hammerschlag Family Investigator University of Massachusetts, Amherst Antti S. Alaräisänen, M.D. University of Oulu Young Investigator MIRIAM KATOWITZ AND Shinichi Kano, M.D., Ph.D. ARTHUR RADIN Young Investigator Johns Hopkins University Katowitz/Radin Investigator Stefan Ehrlich, M.D. Dresden University of Technology ESTATE OF HENRY HANAU Young Investigator Estate of Henry Hanau Investigator Frederick Charles Nucifora, Ph.D., Young Investigator D.O., M.H.S. Herman B. Fernandes, Ph.D. Young Investigator Johns Hopkins University School of Medicine Northwestern University John B. Torous, M.D. Johns Hopkins University Beth Israel Deaconess Medical Center Young Investigator Harvard University LEDUC/CLARK FAMILY George Foussias, M.D, Ph.D. Jeremy’s Family Investigator Centre for Addiction and Mental Health HEINEMEIER HANSSON University of Toronto HH Family Investigator Young Investigator Kristen Elizabeth Pleil, Ph.D. Young Investigator Independent Investigator Weill Cornell Medical College Jason Karl Johannesen, Ph.D. Brian James Miller, M.D., Ph.D., M.P.H. Yale University Augusta University CAROLE AND MARVIN LEICHTUNG Leichtung Family Investigator Young Investigator JOHN KENNEDY HARRISON Arun K. Tiwari, Ph.D. John Kennedy Harrison Investigator Young Investigator Centre for Addiction and Mental Health Danai Dima, Ph.D. University of Toronto Young Investigator Institute of Psychiatry/King’s College London Chung Sub Kim, Ph.D. Young Investigator University of Texas at Austin STEPHEN LIEBER Lingjun Zuo, M.D., Ph.D. Lieber Investigators Yale University HOFMANN TRUST Hofmann Trust Investigator Distinguished Investigator Claes Wahlestedt, M.D., Ph.D. Distinguished Investigator University of Miami Paul John Kenny, Ph.D. Icahn School of Medicine at Mount Sinai

www.bbrfoundation.org 55 ROBERT MCCLEAN TRUST NARSAD RESEARCH FUND Young Investigator Robert McClean Trust Investigator Gwill Newman Memorial Investigator Basar Cenik, M.D., Ph.D. University of Texas Southwestern Medical Young Investigator Young Investigator Center at Dallas Anna Victoria Rotberg Molofsky, Rachel L. C. Mitchell, Ph.D. M.D., Ph.D. King’s College London Independent Investigator University of California, San Francisco Gloria Choi, Ph.D. NEW YORK WOMEN’S COMMITTEE Massachusetts Institute of Technology EUNICE K. MEYER CHARITABLE Women Breaking the Silence About FOUNDATION Mental Illness Investigators Young Investigator Eunice K. Meyer Charitable Foundation Sam Emaminejad, Ph.D. Investigator Young Investigator University of California, Los Angeles Lynnette Astrid Averill, Ph.D. Young Investigator Yale University Young Investigator Corinna Haenschel, Ph.D. Nils Christian Gassen, Ph.D. City University London Young Investigator Max-Planck Institute of Psychiatry Estefania Pilar Bello, Ph.D. Max-Planck Society/Max Planck Institutes NAMI MICHIGAN Instituto de Fisiologia y Biofisica NAMI Michigan Investigator Young Investigator University of Buenos Aires Ronald Gerardo Garcia Gomez, Young Investigator M.D., Ph.D. Christine A. Rabinak, Ph.D. Young Investigator Brigham and Women’s Hospital Wayne State University Laura K. Fonken, Ph.D. Harvard University University of Colorado Denver NARSAD ARTWORKS Young Investigator NARSAD Artworks Investigator Young Investigator Georgia Eve Hodes, Ph.D. James J. Prisciandaro, Ph.D. Virginia Tech Young Investigator Medical University of South Carolina Carol Jahshan, Ph.D. Young Investigator Brentwood Biomedical Research Institute OSTERHAUS FAMILY Carrie Holmberg-Shilyansky, M.D., Ph.D. Jeanne Marie Lee Investigator Stanford University NARSAD RESEARCH FUND Domenici Investigator Independent Investigator Young Investigator Kristen Jennifer Brennand, Ph.D. Orna Issler, Ph.D. Young Investigator Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai Megan Lee Fitzgerald, Ph.D. University of Pennsylvania OXLEY FOUNDATION Young Investigator Oxley Foundation Investigator Chung Sub Kim, Ph.D. NARSAD RESEARCH FUND University of Texas at Austin Stephen G. Doochin Memorial Investigator Young Investigator Haggai Sharon, M.D. Young Investigator Young Investigator Tel Aviv Sourasky Medical Center Hee-Dae Kim, Ph.D. David Louis Pennington, Ph.D. Tel Aviv University University of Arizona Northern California Institute for Research and Education P&S FUND Young Investigator University of California, San Francisco P&S Fund Investigators Mary Claire Kimmel, M.D. University of North Carolina at Chapel Hill NARSAD RESEARCH FUND Young Investigator Daniel X. Freedman Investigator Tjeerd Willem Boonstra, Ph.D. Young Investigator University of New South Wales Benoit Labonté, Ph.D. Young Investigator Laval University Christiaan H. Vinkers, M.D., Ph.D. Young Investigator University Medical Center Utrecht David Bulkin, Ph.D. Young Investigator Utrecht University Cornell University Caroline Menard, Ph.D. Laval University

56 ANNUAL REPORT 2017 Young Investigator Young Investigator Young Investigator Sho Moriguchi, M.D. Surjo Raphael Soekadar, M.D. Timothy Hanks, Ph.D. Centre for Addiction and Mental Health University of Tuebingen University of California, Davis University of Toronto Young Investigator Young Investigator Young Investigator Hanna Maria van Loo, M.D., Ph.D. Laura Magdalen Tully, Ph.D. Veronica Musante, Ph.D. University Medical Center Groningen University of California, Davis Medical Center Yale University Young Investigator ELLEN SCHAPIRO & GERALD Young Investigator Chrystal Vergara-Lopez, Ph.D. AXELBAUM Alexander R. Nectow, Ph.D. The Miriam Hospital Ellen Schapiro & Gerald Axelbaum Princeton University Brown University Investigators

Young Investigator Young Investigator Young Investigator Florian Plattner, Ph.D. Minghui Wang, Ph.D. Christine Elizabeth Gould, Ph.D. University of Texas Southwestern Medical Cold Spring Harbor Laboratory Palo Alto Veterans Institute for Center at Dallas Research (PAVIR) Young Investigator VA Palo Alto Health Care System (VA) Young Investigator Samuel Wilkinson, M.D. Christophe Proulx, Ph.D. Yale University School of Medicine Young Investigator Laval University Yale University Ting Lu, Ph.D. University of Illinois at Urbana-Champaign Young Investigator Young Investigator Marcia J. Ramaker, Ph.D. Nolan Ryan Williams, M.D. Young Investigator University of California, San Diego Stanford University Carolyn I. Rodriguez, M.D., Ph.D. Stanford University Young Investigator ROBERT J. AND CLAIRE PASAROW Matthew James Robson, Ph.D. FOUNDATION SCOTT-GENTLE FOUNDATION University of Cincinnati Robert J. and Claire Pasarow Foundation Scott-Gentle Foundation Investigator Investigator Distinguished Investigator Young Investigator Uwe Rudolph, M.D. Young Investigator Pieter Naude, Ph.D. McLean Hospital Lorna Alice Farrelly, Ph.D. University of Cape Town Harvard University Icahn School of Medicine at Mount Sinai VIRGINIA SILVER Young Investigator PROJECT HOPE Silver Investigator Julia Sacher, M.D., Ph.D. Project Hope Investigator Max-Planck Institute of Brain Research Young Investigator Max-Planck Society/Max Planck Institutes Young Investigator Eleonore Beurel, Ph.D. Sergi Papiol, Ph.D. University of Miami Young Investigator Ludwig-Maximilians University-Munich Martin Schain, Ph.D. JOHN AND POLLY SPARKS Rigshospitalet University Hospital MARC RAPPAPORT FOUNDATION Rappaport Family Investigator John and Polly Sparks Foundation Young Investigator Investigators Jaclyn Marie Schwarz, Ph.D. Young Investigator University of Delaware Theodore D. Satterthwaite, M.D., M.A. Young Investigator University of Pennsylvania Ki Sueng Choi, Ph.D. Distinguished Investigator Icahn School of Medicine at Mount Sinai Etienne L. Sibille, Ph.D. WILLIAM RISSER CHARITABLE TRUST Centre for Addiction and Mental Health William Risser Charitable Trust Independent Investigator University of Toronto Investigators Gabriel S. Dichter, Ph.D. University of North Carolina at Chapel Hill

www.bbrfoundation.org 57 Young Investigator Young Investigator Sarah A. O. Gray, Ph.D. Alexandra Elyse D’Agostino, Ph.D. Tulane University Stony Brook University School of Medicine

Young Investigator Young Investigator Kai Xia, Ph.D. Laura Germine, Ph.D. University of North Carolina at Chapel Hill McLean Hospital Harvard University Independent Investigator Timothy York, Ph.D. Young Investigator Virginia Commonwealth University Tracy Lee Gilman, Ph.D. University of Texas Health Science Center at BARBARA AND JOHN STREICKER San Antonio Barbara and John Streicker Investigator Young Investigator Young Investigator Jacopo Lamanna, Ph.D. Thomas J. Whitford, Ph.D. Vita-Salute San Raffaele University University of Melbourne Young Investigator ESTATE OF OLGA V. TEDESCHI Jonathan P. Stange, Ph.D. Olga V. Tedeschi Investigator University of Illinois at Chicago

Young Investigator THE JOHN P. AND LOIS C. WAREHAM Daniel John Foster, Ph.D. FOUNDATION Vanderbilt University Medical Center Wareham Family Investigator

EVELYN TOLL FAMILY FOUNDATION Young Investigator Evelyn Toll Family Foundation Investigators Pamela K. Douglas-Gutman, Ph.D. University of California, Los Angeles Young Investigator Lot de Witte, M.D., Ph.D. WEISMAN FAMILY FOUNDATION University Hospital Utrecht Adam S. Weisman Investigator Utrecht University Young Investigator Young Investigator Danielle M. Andrade, M.D. R. Matthew Hutchison, Ph.D. University Health Network Harvard University University of Toronto

Young Investigator Jianping Zhang, M.D., Ph.D. Zucker Hillside Hospital Campus of The Feinstein Institute for Medical Research

VITAL PROJECTS FUND INC. Vital Projects Fund Inc. Investigators

Young Investigator Lauren M. Bylsma, Ph.D. University of Pittsburgh

Young Investigator Maithe Arruda Carvalho, Ph.D. University of Toronto Scarborough

58 ANNUAL REPORT 2017 DONORS The Blue Oak Charitable Fund Ms. Gunfer Devres The Boston Foundation, Inc. Mr. and Mrs. Richard A. Edwards Distinguished $250,000+ Mr. and Mrs. Michael P. Breuer EOS Foundation Mr. and Mrs. Ronald E. Chandonais Mrs. Luisa Francoeur and Mr. Jim Goodrich The Norma Z. Bennett Trust The Joseph and Susan Gatto Foundation Dr. Richard H. Gold The Carmel Hill Fund Mr. and Mrs. Alan Hammerschlag Ms. Gail Greenlee Estate of Henry Hanau Mr. John K. Harrison II Michel and Claire Gudefin Family Mr. Stephen A. Lieber Ms. Jamie Heinemeier-Hansson and Mr. Foundation, Inc. Maltz Family Foundation David Heinemeier-Hansson Mr. and Mrs. John E. Hart P&S Fund Honokohau Properties Mr. and Mrs. Kenneth M. Harvey The Estate of Richard A. Roth Independent Charities of America Catharine Hawkins Foundation Vital Projects Fund, Inc. The Rona Jaffe Foundation The Henry Foundation Jewish Federation of Metropolitan Chicago Mr. and Mrs. David Herzer Benefactors $100K + The Kaplen Foundation Mr. and Mrs. Larry J. Hinman Mrs. Gertrude Kornfein Hope Foundation ANONYMOUS (2) Ms. Renata LeDuc Horizon Group Properties The Anne and Ronald Abramson Family Mr. and Mrs. Marvin Leichtung Mr. and Mrs. Thomas N. Iovino Foundation Carole and Harvey Mallement Mr. and Mrs. Martin B. Jacobs The Attias Family Foundation Mr. and Mrs. Milton Maltz Mr. and Mrs. Patrick L. Johnson Mr. Gerald Axelbaum and Ms. Ellen NAMI Long Island Regional Council, Inc. The Katie Foundation, Inc. J. Schapiro Network For Good The Ina Kay Foundation Borrego Foundation, Inc. The Robert J. and Claire Pasarow Quentin J. Kennedy Foundation Gloria Harootunian Revocable Trust Foundation Ms. Karin Kuhns Limberg Family Trust Ms. Teresa Reber Susan Lasker-Brody, MPH The John and Polly Sparks Foundation Mr. and Ms. Curt Robbins Dr. Joan M. Leiman Ms. Claire L. Ruder Mrs. Helen Lowenstein Pacesetters $50K + The Estate of Raphael E. Schwartz Ms. Anne Macdonald The Scott-Gentle Foundation Frances Link Matthews Charitable Fund ANONYMOUS Dr. and Mrs. Mark Silver Estate of Elizabeth L. McAnulty American Psychiatric Foundation Mr. and Mrs. John H. Streicker Mr. and Mrs. Wesley McDonald Beth and Rob Elliott Olga V. Tedeschi Charitable Remainder Barbara McHeffey-Atkinson, M.D. Robert and Rita Elmen Foundation Annuity Trust Morton Family Foundation Suzanne and John Golden TeeTurtle, LLC Neal and Marlene Goldman Foundation Head Family Charitable Foundation Dr. and Mrs. Douglas A. Treco Mr. and Mrs. Rodger L. Nelson HIKE for Mental Health Vention Resources, Inc., PBC New York Presbyterian Hospital The Harriet Himmel Foundation The John P. and Lois C. Wareham The Estate of Sharon Lee Yost Noren Edson D. MacDonald Living Trust Foundation NYS Office of Mental Health The Chris & Melody Malachowsky Family The Lee and Herman Ostrow Family Foundation Patrons $10K + Foundation Mr. Arthur J. Radin and Ms. Miriam Katowitz PayPal Giving Fund Roy H. and Natalie C. Roberts Family ANONYMOUS PLAN of Arizona Special Needs Trust FBO Foundation The Allergan Foundation Timothy Prohart Mr. Jason D. Stipanov The Estate of Dorothy B. Armistead The Portmann Family Charitable Fund The Evelyn Toll Family Foundation Eugene and Carol Atkinson Family Estate of Alla Priceman Susan S. and Kenneth L. Wallach Foundation QMT Associates, Inc. Foundation The Benevity Community Impact Fund Mr. and Mrs. Thomas Rabaut Polly C. Yau Charitable Remainder Unitrust Mr. and Mrs. Robert T. Blanchard Mrs. Margot E. Razziano The Zide Family Foundation Mr. and Mrs. Donald M. Boardman Mr. and Mrs. Mario J. Rossi Gilbert & Ildiko Butler Family Mr. Rowell Leaders $25K + Foundation, Inc. Mrs. Carol A. Rudder Mr. and Mrs. James M. Cavanaugh The Estate of David Schwartz ANONYMOUS (2) The Chicago Community Trust The Jean and Charles Segal Foundation Mrs. Jan I. Abrams Dr. Lawrence J. Child Geoffrey Simon & Andrea Graham Family Mr. and Mrs. Michael J. Bass Columbia University Foundation Mr. and Mrs. Thomas M. Bergers Mary Cooney & Edward Essl Foundation Jean M. Sommers Revocable Trust

www.bbrfoundation.org 59 Mrs. Patricia B. Specter Dr. and Mrs. Mervyn Israel The 2nddate Super Learner Academy Mr. and Mrs. Arthur Janousek Accel Management Company, L.L.C. Team Daniel Running for Recovery from Mr. and Mrs. Mark A. Johnson Agera Energy Mental Illness, Inc. Mr. and Mrs. Mitchell Johnson Mr. and Mrs. Mark H. Alcott Tulchin Family Foundation Ms. Romi Karavites Alex.Brown Ms. Marilyn Waldman Mr. Kevin Kielbasa Ms. Amy L. Alexander YourCause, LLC King & Spalding, LLP Mr. John S. Miner and Ms. C. Nelle Ms. Ellen Krantz Alexander Sponsors $5K + The Jan M. & Eugenia Krol Charitable Mr. and Mrs. John H. Alexander, Jr. Foundation Mr. Peter Alexander and Ms. Alison Starling ANONYMOUS (5) Kuen Lau Research Foundation Mrs. Kimberly Allen Alkermes, Inc. Mr. and Mrs. Howard Levine Already Alive, Inc. Allergan, Inc. Mary M. Lieber Trust Mr. Rebecca Amatangelo Mr. Casey Barnes Mr. Samuel A. Lieber and Ms. Mary E. Rubin AmazonSmile Ben’s Memorial Mile Dr. Piero Dalerba and Ms. Cynthia American Express Foundation Mr. Markus Benzler A. Luppen Ms. Ruth A. Rydstedt and Mr. Ted Dr. and Mrs. Andrew S. Boral Lvl Up Dojo, Inc. T. Amsden Dr. and Mrs. Jeffrey Borenstein Ms. Florence C. Mahoney Ms. Karen J. Andrew Ms. Sharon E. Bowyer Ms. Mary Jo Marron Mr. and Mrs. Bernard J. Armada The Elise and Andrew Brownstein Ms. Kathleen S. Mattoon Ms. Gibi Asmr Charitable Trust Dr. Irving Jacobs and Ms. Jeanette Matye Ms. Amy K. Atkinson Burke Family Foundation Mr. and Mrs. Thomas R. Mayer Mr. James Avallone William F. Byerley, M.D. Maurie & Ethel Meltzer Family Foundation Mr. Daniel M. Axelbaum Ms. Sally Cameron Thomas G. and Andrea Mendell Foundation Ms. Marta K. Bach Ms. Susan C. Bourget and Dr. Peter G. Coles Ms. Maryfrances L. Metrick Mr. and Mrs. R. Walter Bachman Dr. and Mrs. Thomas B. Coles Mr. and Mrs. Eric E. Miehlisch Mr. Alexander Bailey Command Financial Press Corporation Mr. and Mrs. Daniel Mueller Mr. Rajeev Bal Mr. and Mrs. Kenneth S. Davis The Carolyn M. Nagel Trust Mr. Stephen Balek Mr. William T. Deutschendorf Gertrude B. Nielsen Charitable Trust Mr. Peter Bandera Ms. Karmen Dopslaff Dr. Herbert Pardes and Dr. Nancy Wexler Mr. Edwin Bang Trust Under The Will of Elmer J. Dreher Mr. Alan Pierce Mr. Craig Barnard Margaret J. Drury, Ph.D. Mr. Daniel Pipinich Mr. Rob Baron Will & Ann Eisner Family Foundation, Inc. Ms. Riska Platt-Wanago Ms. Marybeth Barraclough Dr. and Mrs. Bulent Ender Mr. Marc R. Rappaport Mr. and Mrs. David O. Barrows Mr. Michael G. Fisch The Toby and Nataly Ritter Family Mr. and Mrs. Richard A. Bartlett Flaxman Family Charitable Trust Foundation Mr. John Barton Fortune Family Foundation Ms. Kathleen F. Rorick-McNichol and Ms. Marie Basalone Mr. and Mrs. Gary Furness Mr. James D. McNichol Mr. and Mrs. Michael Becker G2 Foundation Ms. Mara Rosenstock Mr. and Mrs. Mitchell Becker The Gaddis Family Foundation, Inc. Ms. Sarah L. Schnarr Ms. Kristy Beck-Nelson The Joseph and Anna Gartner Foundation Schwartz Survivor’s Trust Mr. and Mrs. Robert W. Belyea Mr. and Mrs. Robert W. Geyer Ms. Marylou Selo Mr. Donald E. Benkeser Mr. and Mrs. Thomas G. Gillis Elinor Beidler Siklossy Foundation Mr. and Mrs. P. Bruce Benzler D.W. Gore Family Foundation Ms. Margaret E. Sokol Mr. and Mrs. Brian Berger Mrs. Martha S. Graham Kenneth H. Sonnenfeld, Ph.D., J.D. The Herman Berger Family Trust The David F. and Margaret T. Grohne Ms. Dorothy Sprague Ms. Amy Berko-Iles Family Foundation Sunovion Pharmaceuticals, Inc. Ms. Susan Berry Mr. Leonard L. Gumport and Ms. Ms. Barbara Toll Mr. Nathan Betnun Wendy Munger UBS Mrs. Anne L. Bird Mr. and Mrs. Martin Gundersen Virtual Strides Mrs. Roger Biron Marilyn G. Harwood Fund Edward N. & Gladys P. Ziegler Foundation Mr. and Mrs. Michael F. Bishay Mrs. June M. Henebury Mr. and Mrs. John P. Bishop, Jr. Mr. Aaron Hess Associates $1K + Mr. and Mrs. Gary N. Bjorklund The Estate of Greta Horn Mr. Elliott Blake Mrs. Suzanne C. Hoyt ANONYMOUS (8) Mr. and Mrs. Paul Blaskowski

60 ANNUAL REPORT 2017 Dr. and Mrs. Harold Bloom Mr. and Mrs. Craig Clendening Ms. Tamara Edwards-Wilson Mr. and Mrs. Benjamin D. Blosch Dr. and Mrs. James E. Clune III Eileen Fisher Mr. and Mrs. Sidney A. Blum Ms. Karen D. Cohen EJL98 Charitable Trust Dr. and Mrs. Benje Boonshaft Mr. and Mrs. Martin Cohen Ms. Diana Elghanayan George S. Borgida Trust Mr. and Mrs. Martin Cohen Ms. Annikki H. Elkind Boston Financial Data Services, Inc. The Arnold Cohn Trust Ms. Michelle Elston Estate of David H. Boxer Ms. Judith E. Cohn Richard B. Evans, M.D. Mr. Eric Boyko Ms. Emma Cole Mr. and Mrs. Preston C. Everdell Ms. Kimberly Bradley-Dumas Mr. and Mrs. Michael G. Coles Mr. and Mrs. Michael F. Falkner Mr. Thomas J. Brennan Collins Building Services, Inc. (CBS) Gloria & Hilliard Farber Foundation BrightView C&J Collins Family Foundation Mrs. Stephanie Feinland Mr. and Mrs. Peter M. Briscoe Mr. and Mrs. John C. Colman Mr. Daniel Feith Mr. James Brook and Ms. Isabelle Computer Learning and Resources Mr. and Mrs. Randy Ferguson Pinzler-Brook Center, Inc. Mr. and Mrs. John Fidaleo Ms. Deborah Brown Mr. Guillermo Concepcion The Fine Foundation Robert M. Brown & Thelma Y. Brown Dr. Michael W. Condie George R. & Elise M. Fink Foundation Foundation Ms. Eva Cooper Ms. Mary M. Finley Dr. Carl N. Brownsberger and Mrs. Susan Ms. Mary Costello-Campbell Ms. Laura Finn Brownsberger Ms. Elizabeth Costigan-Fischelis First Manhattan Company Dr. and Mrs. William J. Brownstein County of Santa Clara Warrant Dr. Roger L. Fischer Ms. Megan Buchanan Ms. Judith M. Craig The Warren and Deb Fisher Charitable Fund Mr. and Mrs. George Bundschuh Dr. Margaret Crastnopol Rabbi Lyle A. Fishman and Ms. Debra Jeffrey J. and Mary E. Burdge Charitable Mr. and Mrs. Denis F. Cronin A. Rosenman Trust The Curtis Encouragement Fund Mr. Kenneth Flanders Mr. and Mrs. John C. Burke Mr. and Mrs. Edward H. D’Alelio Ms. Carol Flaumenhaft Mr. and Mrs. Paul T. Burke Dammann Fund, Inc. Flint Hills Resources Grain, LLC Mr. and Mrs. Jay Bushnell Mr. and Mrs. Aaron Daniels Mr. Jared Fontenette Ms. Catherine Caldwell Mr. and Mrs. John Daus Ms. Betsy Foreman Mr. James M. Call Dr. Jan De Bakker and Mrs. Gerarda Ms. Veronica K. Franchino PJ Callahan Foundation, Inc. De Bakker Mr. and Mrs. Bradford F. Freer Ms. Sarah Callender Mr. and Mrs. William Dean Ms. Helen Friedman Mr. David Calvin and Ms. Constance Page Mr. and Mrs. Timothy A. DeLapp Mr. and Mrs. H. Bruce Friedrich Mr. and Mrs. Joseph S. Campbell Ms. Nancy C. DeLuca Mrs. Patricia Fuller Mr. Christopher Campbell Mr. and Mrs. David Derman Donald Furman, O.D. Candlewood Lake Boat Rentals, LLC Mr. and Mrs. Richard K. Descherer Mr. and Mrs. Robert W. Gadsden Dr. Scott C. Berk and Ms. Kathryn Mr. and Mrs. E. Everett Deschner Mr. Ronald R. Zeller and Ms. Susan M. A. Cannon Mr. and Mrs. Richard DeStefano, Sr. Gallagher Mr. and Mrs. Gerald Capodieci Mr. and Mrs. David Diffley Gansett Foundation Mr. Dodi L. Carlton Dr. Josh Dillon Ms. Catherine B. Gardner Mr. and Mrs. Steven L. Carson The John D. & Jean E. Dinan Foundation Dr. Jess W. Gaspar Mr. Paul G. Caslavka Mr. Michael Dipietro Gaytan & Leevan, LLP Mr. and Mrs. Daniel J. Castellani Mr. and Mrs. William R. Dodds, Jr. Mrs. Nancy S. Geller Charlottesville Area Community Foundation Reverend and Mrs. Richard L. Dowling The Generosity Trust Chevron North America Exploration Drake / Anderson, LLC Mr. George W. Gephart, Sr. and Production Company Mr. and Mrs. R. Larry Drake Mr. Jeffery Gerbitz Mr. and Mrs. George Childs Kohn Dr. Eric M. Dreyfuss M. Rameen Ghorieshi, M.D., M.P.H. Mr. Madhav Chinnappa Mr. Matthew J. Drinkwater and Dr. Adrienne Mr. and Mrs. Steven A. Gibson Mr. D.M. Chitre S. Drinkwater Mr. and Mrs. Charles A. Gilbert Mr. Randolph F. Christen Dr. Marc Dubin Mrs. Betty B. Giles Mr. Lloyd Christiansen Mr. and Mrs. Rob Duncan Mr. and Mrs. Ted S. Gladstone Ms. Barbara M. Christy Mr. and Mrs. Thomas H. Duncan GNYHA Ventures, Inc. Ms. Barbara L. Chuko Mrs. Anna Dunigan Ms. Ellen T. Goldman Citarella Gourmet Market Ms. Rebecca Eden Goldman Sachs Philantrophy Fund CJR Foundation, Inc. Eden Hall Foundation Mr. and Mrs. William B. Goodson Ms. Lillian Clagett Julian I. and Hope R. Edison Foundation Gordon Family Charitable Foundation

www.bbrfoundation.org 61 Ms. Laurie L. Gordon Institutional Venture Partners (IVP) Mr. and Mrs. Gwilym R. Kroll Dr. and Mrs. Edward J. Grabowski INVNT Mr. and Mrs. Werner Kroll Ms. Diana Graeber Mr. Karl Irish Kroll’s Fall Harvest Farm Ms. Lorri Grainawi Mr. David Isley Mrs. Marilyn R. Krueger The Grant Family Fund A.C. Israel Foundation, Inc. Mr. Thomas Gilroy and Ms. A. Margaret Mr. and Mrs. Eugene M. Grant J Squared Press, Inc. Krugers-Gilroy Mr. and Ms. Bennett G. Grau J.R. Realty Corporation Mr. Shane D. Kucera Ms. Rebecca Green Angela Jackson, O.D. The Jesse & Joan Kupferberg Family David E. Green Memorial Scholarship Fund Mr. Eric M. Jackson Foundation Mr. and Mrs. Robert J. Greenberg Mr. and Mrs. Jeffrey A. Jackson The Kenneth & Harriet Kupferberg Family Mr. and Mrs. Jesse J. Greene, Jr. Mrs. Vivian B. Jackson Foundation Mr. and Mrs. Kevin M. Greene Mr. and Mrs. Thomas A. Jacobs Mr. Sydney Temple and Ms. Sarah J. GreMar Investments Mr. and Mrs. Thomas B. Jahncke Kupferberg Ms. Lynn Griffin Mr. Achyut Jajoo Mr. and Mrs. J. Wesley Kussmaul Mr. Andrew Griffith Mrs. Marion Jamgochian Dr. Ann C. Laitman and Dr. Robert S. Mrs. Margaret E. Grube Mr. James P. Jamilkowski Laitman Dr. Georgia Gudykunst Dr. Hyun-Hwan Jeong and Ms. Seon Charna and Alan B. Larkin Mr. Frank Gumma Young Kim Philanthropic Fund Mr. and Mrs. Donald A. Gunness Mr. and Mrs. Charles B. Johnson Mr. Brian S. Latell Mr. and Mrs. Rob Gushurst The Ted and Ruth Johnson Family Mr. and Mrs. Gary Lathrop Mr. and Mrs. John A. Hager Foundation Mr. and Mrs. David Laubach Mr. and Mrs. Roscoe O. Hambric, Jr. Mr. and Mrs. Donald Jonas Ms. Jill D. Lawrence Ms. Yvonne S. Hannan Mr. and Mrs. Peter S. Jonas Ms. Joan M. Lechner Mr. Everette P. Hardy Mr. and Mrs. Kurt L. Jones The Nancy K. Leonard Revocable Trust Mr. and Mrs. Norm Harper Justgive Ms. Reva Leung Harris & Harris, Ltd. Dr. and Dr. Harry Kahan Ms. Annie F. Levine Ms. Mary Jo S. Harrison Mr. and Mrs. David R. Kampff Ms. Diane Levine Ms. Cynthia Harwell-Paar Mr. and Mrs. Igor Kaper Ms. Ellen R. Levine and Dr. Richard U. Dr. Samuel E. Hazen Mr. and Mrs. Michael J. Kastenholz Levine Mr. Christian Heaviland Ms. Elizabeth L. Kaye Mr. and Mrs. Robert LeVine Mr. and Mrs. Albert P. Hegyi Ms. Sandra Kazlow Mr. and Mrs. Daniel Levy Mr. and Mrs. Brad W. Hentschel Kehl Family Fund Mrs. Ellen F. Levy Mr. Sheldon H. Herman Dr. Eric Keisman Dr. Edward Libby Mr. John Heyman Ms. Elizabeth G. Keller Clemence S. Lieber Foundation, Inc. Hildebrand Charitable Fund Mr. Howard A. Kellman Robert J. Lieber Charitable Trust Mr. Chad Hilgenbrinck The Kelly Foundation Mr. and Mrs. James Locatelli Mr. Arthur W. Hills and Ms. Mary Ms. Judith S. Kelly Mr. and Mrs. John S. Logue Pilkington-Hills Mr. Karim Khalil Mr. and Mrs. John Lohmeier Mr. and Mrs. David A. Hirsch Mr. Satkartar Khalsa Mr. Kevin M. Lois Mr. and Mrs. Ralph J. Hitchcock Mujahid Khan, M.D. Ms. Marilyn Loken Mr. and Mrs. Robert A. Holmstrom Dr. Romel R. Khan Ms. Estela M. Long Mr. Logan Hood Mr. Gurinder Khosa Mr. and Mrs. Harvey S. Long Mrs. Hazel Hundert Kathryn Kiebel, CSCP Ms. Linda Lou Lopez Rita G. Hungate, M.D. Ms. Yvonne S. Kilbourne Dr. Dan C. Lortie and Dr. Grace Budrys Ms. Sarah M. Hunt Mr. Frank Kilpatrick Mr. and Mrs. L. Alan Lowry Mrs. Gail J. Hurvitz Ms. Elizabeth N. Kimball Ms. Isabella Lubin Mr. and Mrs. John A. Hurvitz Mrs. Lynn Kimble Mr. and Mrs. Andy Lueck Mr. and Mrs. Daniel B. Hurwitz Mr. and Mrs. Ira D. Kleinman Ms. Susan A. Luerich Mr. and Mrs. Craig Hutson Mrs. Susan Kocmond Ms. Gina Lupica Mr. David Hyde Kohn Family Corporation Ms. Cheryl MacLachlan and Mr. Fred Mr. and Mrs. Robert Ianni Mrs. Helen P. Koskinas S. Gorelick Mr. Stede Ingram KPMG–Matching Gifts Program Mr. Donald Chin and Ms. Grace Mah Mrs. Mary T. Ingriselli Ms. Ruth B. Kramer Beth Maher Family Foundation Mr. and Mrs. Louis Innamorato Mr. and Mrs. Howard G. Kristol Mr. Kevin P. Maher Institute for Professional Education, Inc. Mr. and Mrs. Ted Krolikowski Ms. Katherine Mahlberg

62 ANNUAL REPORT 2017 Mr. and Mrs. Joseph K. Maiuro Mr. and Mrs. Richard Novick Ms. Min S. Ro Mallard Financial Partners, Inc. Ms. Anna O’Brien Max Robinowitz, M.D. and Carolyn B. Mr. and Mrs. Larry Margolis O’Callaghan Family Foundation Robinowitz, M.D. Mr. and Mrs. Cornelius Marx O’Connor Professional Group, LLC Mr. and Mrs. Daniel G. Rodgers Ms. Patti M. Masarek Mr. and Mrs. Michael Olivier Mr. Kevin Rogers Dr. and Mrs. Sanjay Mathew OMOCAT Mr. and Mrs. C. Carlyle Rood Mr. Joseph Matza Mr. Ellis M. Oppenheim and Dr. Lois Mr. and Mrs. Robert B. Rosen Mr. and Mrs. Bayard R. Maybank L. Oppenheim Ms. Raquel Ross Mrs. Mary E. McAward Mr. and Mrs. Donald E. Owen Mrs. Donald I. Roth Mr. Robert J. McCormick Mr. Robert Panariello Mr. and Mrs. Michael R. Rothman McDermott Will & Emery, LLP Mrs. Bonnie A. Parker Mr. Paul A. Roush Ms. Jolynne McDonald Dr. and Mrs. Roderic A. Parnell, Jr. Mrs. Elizabeth H. Rousseau Ms. Katherine H. McNabb Ms. Maureen T. Parris Mrs. Michelle R. Rowe Mr. and Mrs. Ward McNeilly Ms. Laure Parsons Dr. George Rozanski Ms. Ellen C. Meadows Ms. Louise J. Passick Mr. and Mrs. Anthony D. Rully Mr. Dennis Ladick and Ms. Karen Mr. and Mrs. Leland R. Payton The Runstad Foundation L. Meadows Dr. Arthur Peck Mr. and Mrs. Arthur A. Russ, Jr. Mr. William Megowen Mrs. Mary J. Pedrosa The Nancy Ruth Fund Mr. and Mrs. Robert Meltzer Mrs. Ronnie J. Pelle RZ Foundation Robert and Joyce Menschel Mr. Christopher Pencavel S&P Global Family Foundation Mr. David H. Perecman Mr. and Mrs. Reuben H. Saideman The Emil and Toby Meshberg Mrs. Marilyn M. Phillips-Bever Mrs. Willmetta P. Saldin Family Foundation Mr. Leonard Pitt The Salice Foundation Dr. Carol A. Meyer Mr. John Pittman Ms. Mary C. Salpukas Mr. and Mrs. Bernard M. Meyers Mr. Craig Plunkett Mr. and Mrs. Jack Saltz Mr. and Mrs. Anton J. Michelich Mr. and Mrs. Peter Z. Powchik Jos. T. Samuels, Inc. Ms. Constance Miller Prestige Stamping, Inc. Dr. William E. Sanson Mr. and Mrs. Michael E. Miller Mr. Roger Prior and Dr. Barbara A. Page Mrs. Harriet R. Sarkaria Mr. Sydney A. Miller-Schaefer Mr. and Mrs. Grant E. Propper Mr. and Mrs. Jay Sarles Dr. and Mrs. William J. Mitchell PsychoGenics, Inc. Dr. Mark A. Satterthwaite and Dr. Lauren Modell Family Charitable Fund Mrs. Linda J. Purdy-Ohland M. Pachman Mr. J. Clifford Moos Pure Noise Records Ms. Sheila Scharfman Ms. Ornella Morrow Mr. and Mrs. Brad A. Purifoy Mr. E. James Morton and Ms. Matthild Mr. and Mrs. Marcel Mouney Pzena Investment Management C. Schneider Mr. Michael B. Mower Ms. Susan P. Quasney Ms. Constance Schnuck Mr. Christopher Moyer Dr. and Mrs. Mohammad E. Qureshi Mr. and Mrs. Edward J. Schoenecker Ms. Meaghan E. Mullgardt Isadore A. Raff Family Foundation, Inc. Nina R. Schooler, Ph.D. Mr. and Mrs. Eric W. Murchison Mr. and Mrs. Timothy Railton Mr. Daniel J. Schreiber Mr. Kevin Murray Mr. Anthony R. Rando Ms. Amy B. Schumer Mr. Robert J. Myers and Ms. Qian Zhuge Ms. Jane D. Rappleyea Mr. Marc A. Schwartz Ms. Rita Nalebuff Mrs. Sharmila Ravi Tommy R. Searle NAMI - Eastside Support Group Mr. and Mrs. Jerry B. Redden Dr. Lloyd I. Sederer and Ms. NAMI Newton Wellesley Eastern Ms. Nancy Reeve Rosanne Haggerty Massachusetts, Inc. Mrs. Edith J. Rein Mr. Ron Sefried Mrs. Jane Nance Mr. Erik Reynolds Mr. Jared N.D. Selengut Nature’s Gift Shop, LLC RFR Realty, LLC Seleni Institute / Seleni House Mr. Venicio Navarro Lawrence I. & Blanche H. Rhodes Foundation, Inc. Newbury Animal Hospital Memorial Fund, Inc. Ms. Bethany Sexton Ms. Crystal Nguyen The William D. Rhodes Foundation Mr. Robert Shaffer Ms. Diep Nguyen Mr. and Mrs. Joseph J. Ricci Mr. Rajan Shah Ms. Mary M. Nicol Ms. Rhoda G. Rice Dr. and Mrs. Sherman Shapiro Night Light Marketing Concepts, LLC Mr. Derek Richards Sharp Mesa Memorial Hospital Mr. and Mrs. David Noack Mr. Gage M. Richert Mr. and Mrs. Andrew Sheinman Mr. Wayne Nosal Mr. and Mrs. Don Rigoni Mr. and Mrs. John L. Sheldon Mr. Mathieu Nouzareth The Riven Company, LLC

www.bbrfoundation.org 63 Ms. Jean C. Sheller and Mrs. Dr. Stephan F. Taylor and Ms. Elizabeth Mr. Paul C. Williams and Ms. Leslie Berger Roberta Fricker A. Stumbo Dr. and Mrs. Martin S. Willick The Sibley-Saltonstall Charitable Henry B. Test Trust Mr. and Mrs. Steven A. Wils Foundation Ms. Manisha A. Thakor Mr. and Mrs. Jeffrey J. Wilson Mr. David R. Sicular and Ms. Lilian Mr. Jorgen Thelin Mr. and Mrs. William D. Wilson Stern-Sicular Mr. Lukasz Thieme Winslow & Company, LLC Mrs. Lilian Sicular Ms. Doris Toolanen Mr. and Mrs. John Winter Mrs. Vanessa Siegel Mr. Taylor Townsend Mr. Sudhir Wokhlu Silicon Valley Community Foundation Mrs. Esther F. Trachtman Dr. and Mrs. Stephen C. Woodward Ms. Carolyn Silverman Ms. Margaret A. Trefz World Heritage Foundation-Prechter Ms. Jeanne Silvers Mr. and Mrs. Timothy C. Tuff Family Fund Ms. Pamela Silverstrim Mr. Walter McCarthy and Ms. Clara Mr. Selam Yihun Mr. Dan Simon M. Ueland The Yoji Fund Drs. Marilyn and James Simons United Way of Greater Milwaukee and Ms. Jeanne Zambelli The Jeffrey I. Simons Charitable Foundation Waukesha County Mr. and Mrs. Thomas Zambrano Mr. and Mrs. Sanford Sirulnick United Way of Snohomish County Mr. Abraham N. Zavala Mr. David Sisler United Way of Tri-State Mrs. Renee S. Zenker Mr. Gary J. Skoien United Way, Inc. Ms. Karen Zimmer Mrs. Barbara R. Smith University of Pittsburgh Mr. Phillip Zook Mr. Sean Snyder Mr. and Mrs. Juan Vallarino Mr. Mark R. Sokol Mr. David Van Brunt Supporters $500 + Mr. Jordan Sorensen Ms. Cheryl Vance The Timmy Spada Memorial Foundation Laurie Louise Volk Giving Account ANONYMOUS (4) The Spangler Family Fund Mr. Samuel C. Vrooman 1iX Network , LLC Mr. and Mrs. Paul Sprague Mr. and Mrs. Del Wach Mrs. Virginia A. Aaron Ms. Susan E. Stanton Mr. and Mrs. Steven R. Wagner Mr. and Mrs. Celso C. Aberin Starfish Holdings Group, Inc. Mr. James Walker Mr. Santhosh Abraham Dr. Susan Stauffer Alissa Wallace Charitable Lead Trust Mr. Jeremy Abrams Ms. Elizabeth Steele Mr. Paul M. Warner Mr. and Mrs. Tim G. Abrams Mr. Francois Stehlin Warren County Foundation Depository Dr. Mark H. Kinn and Ms. Hannah Dr. Michael L. Stein and Ms. Laurie J. Butler Dr. Douglas Warsett and Ms. Susan Warsett Achtenberg-Kinn Ms. Sherri M. Stephenson Ms. Deanna Watson Dr. Jonathan S. Adelstein Arthur & Edith Stern Family Foundation Weill Medical College of Cornell University Mr. John Adler Mr. James M. Stichnoth John L. and Sue Ann Weinberg Foundation Mr. Kevin Adrian Mr. Gregory Stilwell Mr. and Mrs. Jay Weisbrod Mr. and Mrs. Edward Albers Mrs. Diane Stokes Mr. Howard P. Weiss Mr. and Mrs. Oscar Alerhand Mr. and Mrs. Ronald V. Stone Ms. Joyce L. Weiss Mr. and Mrs. Charles E. Allen Stone Foundation, Inc. Myrna M. Weissman, Ph.D. Dr. Lauren B. Alloy Mr. and Mrs. Richard Strasbaugh Wells Fargo Foundation Allstate - The Giving Campaign Mrs. Lynn G. Straus Mr. Mark Welsh Mr. Joe Altman Stronge Family Foundation Mr. and Mrs. Harvey Wertheim Mr. David Anderson Dr. and Mrs. Krishnamoorth D. Mr. and Mrs. Michael B. West Ms. Lauren B. Anthone Subramanian Mr. and Mrs. Stuart Wester Mr. and Mrs. Kurt Apen Dr. and Mrs. Myron Susin Josh and Judy Weston Family Ms. Marisa Arango-Berry The Bernard M. and Caryl H. Foundation, Inc. Mr. Richard Arkin Susman Foundation The Westport Fund Mr. Rollin A. Armer Dr. Andrea Swan The Whetzel Family Charitable Trust Mr. and Mrs. Frank G. Arnstein Mr. and Mrs. Frank H. Swanson Mrs. Phyllis Whisler Mr. Jay Aronson Mr. and Mrs. Gordon E. Tagge Mrs. Virginia J. Whitcombe Ms. Kathleen A. Asser-Weslock Ms. May-Ling Tang Mr. and Mrs. Thomas C. White Ms. Linda M. Awn Mr. and Mrs. Geoffrey Tate Mrs. Kelly Whittington Mr. Bruce W. Baber Mr. Charles M. Tatham and Ms. Joanne Mr. John P. Wierzba and Ms. Ruth A. Ms. Arleen Baez Adamko-Tatham Lane-Wierzba Baird Foundation, Inc. Mr. and Mrs. William B. Tausig Mr. and Mrs. Michael Wigler Mr. and Mrs. Thomas J. Bak Mrs. Elizabeth J. Taylor Wilf Family Foundations Mr. Brian Baker

64 ANNUAL REPORT 2017 Ms. Jo Ann H. Ball Mr. and Mrs. Peter Choma Mr. and Mrs. Daniel Dugan The Bandier Family Foundation Mr. Bradley Green and Dr. Jennifer Dulinski Family Foundation Mr. James G. Banghart Chou-Green Ms. Mary Eaton Mrs. Julie Barto Churchill Leadership Group Dr. and Mrs. Bennett Edelman Ms. Mary P. Bartoszek Mr. Mark W. Chutter and Ms. Lorna B. Ellis Mr. Chris A. Edwards Dr. and Mrs. John R. Baudler Kasey R. Claborn, Ph.D. Mr. Michael Edwards Mr. Josh Bauer Coastal Community Foundation of The John Lee Eichman and Jaque (Janice Ms. Linda L. Bauer S.Carolina (Everyday Hero) Louise) Karnowski-Eichman Charitable Mr. David Baumgarten Mr. and Mrs. David Cohen Fund Mr. James A. Beer Mrs. Karen L. Cohen El Cajon Roofing Mr. Jake Cornelius and Ms. Christina Bell Mrs. Barbara Cohn Mr. and Mrs. Michael G. Eller Mr. and Mrs. William J. Bell Mr. Christopher Colligan Mr. Sean Enck Ms. Clara Bennett Ms. Anne Conte Dr. Mark Engelhardt Mr. Zachary Z. Benson Ms. Virginia K. Coogler Ms. Bonnie S. Englebardt-Lautenberg Mr. and Mrs. Roger J. Berdusco Mr. and Mrs. Curtis H. Cornwell Mr. and Mrs. Mark W. Engstrom Mr. and Mrs. Elliot Berger Mr. Daniel Coyne Mr. and Mrs. Robert Eubanks Berlin Health Mrs. Cynthia J. Crawford Ms. Kate S. Ezra Ms. Indu Berman Mr. Daniel E. Cromie Louis J. Facchino, Jr., LMFT Mr. and Mrs. Gene Bernardoni Mr. and Mrs. John G. Culkin Mr. Gerald Faigeles Ms. Thérèse D. Bernbach Ms. Johanna S. Cummings Mr. Pedram Farahnak Mr. and Mrs. Edward Black Ms. Tracy Cumpson-France Dr. and Mrs. Ahmed A. Fareed Mr. and Mrs. Peter Bloom Mr. John W. Curtis and Ms. Margaret Mrs. Ann V. Christie and Mr. John Fattibene Mr. and Mrs. Dale Blue A. Sarkela Mr. Frank Schiff and Ms. Andrea Feirstein Jacob Bluestein Foundation Mr. Jorge Da Silva Mr. and Mrs. Albert Fenner Bold & Bright, INC. Ms. Sandra D. Dalvit-Dunn Ms. Christine Ferer Ms. Jordan N. Bolden André & Marilyn Danesh Fund Ms. Patricia Fernandez Mr. Daniel Boorse Ms. Cheryl J. Daniel Fidel Dental Group Mr. Harry W. Boothe Dr. Richard E. Darilek Fidelity Investments Charitable Gift Fund Mr. Brian Boudreau Mr. Sigmund E. Davidson Ms. Lois A. Fitton Mr. and Mrs. Norman H. Bouton, Jr. Mr. and Mrs. Lawrence E. Davis Ms. Jacqueline Flaherty Mr. Lloyd Bowers III Mr. and Mrs. Sean P. Davis Mrs. Lorraine Fleser Mr. Mr. David Davitz Flower Family Foundation Dr. Glen Brennan Mr. John de Yonge Mrs. Margaret A. Flynn Bright Funds Foundation Mr. Henry DeAngelis, Jr. Ms. Kelly A. Frawley-Johnson Dr. Adriana D. Briscoe Mr. Peter Dederick Mr. and Mrs. Thomas Frayda Mr. Richard Romano and Ms. Annette Mr. and Mrs. Dennis F. Deely Mr. and Mrs. Mark Frederick Bugatto-Romano Mr. and Mrs. Michael B. DeFlorio Mr. and Mrs. Lewis L. French Mr. Frank Buhrmann Mr. and Mrs. Gaspare R. DeGaetano Diana L. Furrow, LPC Mr. and Mrs. Michael Burczak Dr. José DeLeon and Ms. Victoria Martinez Ms. Naheda Fustok Burnett & Williams Mr. and Mrs. Dale A. Dellutri Dr. Wen-Jun Gao Mr. Kenneth Burns Mr. and Mrs. Larry Dennis Ms. Rachel Garb Ms. Patricia Buser Ms. Helle K. DeSimone Dr. Gerald L. Geison Memorial Fund Mr. and Mrs. David Byron-Brown Deutsche Bank Americas Foundation Mr. Robert C. German and Ms. Pamela Lacy Mrs. Elvira Cabreja Mr. and Mrs. Ron Deutschendorf Mr. and Mrs. Leonard Gero Mrs. Jane L. Calvin Dr. and Mrs. Pedro M. Diaz Mr. Philip Gerring Mr. Blayne Cannon Mr. and Mrs. Joseph DiMartino, Sr. Ms. Julia Getzels Ms. Karen Cannon Ms. Rose F. DiMartino Mr. Jeffrey D. Gilbert Mr. and Mrs. David Cantor Ms. Anne M. D’Innocenzio Mr. Brandon Giliberti Mr. Jeffrey W. Carlson Mr. and Mrs. Richard A. Dobbins Give with Liberty - Employee Donations Mrs. Catherine Carlton Dr. and Mrs. Stephen E. Dolgin Gobal Technology Transfer Group, Inc (GTT) Mr. Roderick D. Carroll DonateWell Mr. and Mrs. Lionel Go Mr. Peter B. Case Ms. Krysta Dos Santos Mr. and Mrs. Arthur A. Goldberg Mr. Joseph Chemero Mr. Mark Dostal Mr. and Mrs. Jay Goldberg Ms. Rebecca Chen Ms. Heather M. Draz Mrs. Wendy J. Goldstein Mr. and Mrs. R. Paul Chlan Mr. Steven R. Dreben

www.bbrfoundation.org 65 Pierre and Paula Gonthier Family Barry H. Horowitz, C.P.A., M.S.T. Mr. and Mrs. Roger L. Knight Foundation Ms. Sheryl L. Howe Mr. Brandon T. Koch Michael and Lola Goodstein Charitable J.M. Huber Corporation Mr. and Mrs. Andrew P. Kohl Foundation Trust Humble Bundle, Inc. Mr. Madhuri Kondepudi Ms. Esther Z. Gordon Mr. and Mrs. Bob Hunter Mr. and Mrs. Andrew W. Korinda The Gould-Shenfeld Family Foundation Ms. Fern K. Hurst The Curtis I. Kossman Foundation Ms. Gail M. Gouvea Mr. and Mrs. Ken Huston Ms. Marjorie C. Brandriss and Mr. David Mr. David Graham Dr. Donald E. Hutchings M. Kristol Granite Global Ventures Capital (GGVC) Ms. Melissa Huther Richard J. Kruger Foundation Ms. Ellen C. Grassman Mr. and Mrs. Jaime Hutter Drs. John H. Krystal and Bonnie Becker Mr. and Mrs. Edward A. Gray Ms. Sarah Ibrahim Mr. Kevin Kuell Dr. and Mrs. John M. Grohol ImpactAssets, Inc. Mrs. Susan K. Fisher Mr. Joe Grossman Dr. and Mrs. Richard A. Insel Mr. and Mrs. Kai C. Lam Mr. and Mrs. Allen J. Grubman Mr. Timothy Irons Mr. and Mrs. George Lantos Ms. Michelle Gumport Mr. and Mrs. Norman Isler Mr. and Mrs. Fred M. Lara Ms. Renee M. Cassidy and Mr. Jordan Mr. Eric Jackson Dr. Janine M. LaSalle D. Gushurst Mr. John M. Jackson Ms. Dianne C. Leech Mr. Jason Haber John Mary & Bernard Jacobs Foundation Mr. and Mrs. James C. Leichtung Mr. and Mrs. William R. Hacker Mr. and Mrs. Sidney S. Jacobson Saul M. Levin, M.D., M.P.A. Mr. Gregory Haffner Mr. Niles Jager Ms. Annie Levine Dr. and Mrs. William H. Hague Ms. Carolyn R. Jakopin Mr. and Mrs. Marvin A. Levine Mr. and Mrs. David Halpern Mrs. Holly Jankiewicz Frances and Jack Levy Foundation Mr. and Mrs. Jerry M. Hamovit Mr. and Mrs. Orest D. Jarosiewicz Dr. Barbara Lew Ms. Barbara Handler Ms. Lisa Jensen Mr. Matthew Shear and Ms. Sarah M. Lewin The Handley Foundation, Inc. Johnson & Johnson–Matching Gifts Dr. and Mrs. Peter Liebert Hard Surface Solutions (HSS) Program Mr. Donald Littleton Mr. Jack R. Harkins Mr. and Mrs. Schuyler W. Johnson Mr. and Mrs. Michael D. Logan Mr. Christopher L. Harper Ms. Penelope D. Johnston-Foote Ms. Pat Lokey Ms. Susan Harper Ms. Elizabeth B. Jones Ms. Clara F. Londoner Harrigan Leyh Farmer & Thomsen, LLP Ms. Gail B. Jones Mr. and Mrs. William Loomis (HLF&T) Ms. Mary E. Jones Ms. Natasha Lopez de Arenosa Mrs. Claudine M. Harris Mr. Daniel S. Jordan and Ms. Claudia L. Mr. Brian Loughrin Mr. and Mrs. Stanley Harris Ginsberg Ms. Ann Lowry Mr. Lee Harrison Mr. Donald Josey Jun Lu, M.D. Mrs. Esther M. Hartman The K Foundation (TKF) Mr. and Mrs. Carl A. Lund Mr. Chris W. Haskell Mr. and Mrs. Robert R. Kain Mr. Thomas A. Lunney Mr. Benjamin J. Haskin Mr. Roham A. Kalkhoran Mrs. Jean Lyman Dr. Cecilia W. Hawkins Mr. Matthew D. Kalos Mr. and Mrs. Richard Lynch Ms. Marian G. Hayes Mr. and Mrs. Joseph J. Kaminski Mr. Douglas Macnab HeadStrong Club Ms. Kathe Kane Ms. Dawn M. Macreadie Mr. John J.H. Phillips and Ms. Carolyn Healy Mr. Matthew Kaplan Mr. Daniel C. Madsen Ms. Phyllis Heischuber Mr. Jim Karanouh-Schuler Ms. Shyma Maharaj Mr. David D. Ontaatje and Ms. Elizabeth Ms. Billie Kasper Maine Tennis Foundation Heneghan-Ondaatje Ms. Claire Kayacik-Balgemann Mr. Jose L. Manzo Mr. and Mrs. Henry L. Herman Mr. and Mrs. Andrew Keegan Mr. Anthony J. Marangiello Mr. and Mrs. Marvin L. Higgins Hale and Andrea Kell Mr. John D. Marangiello Merle Hilliard Charitable Trust Mr. and Mrs. Robin Kent Ms. Lauren Marangiello Ms. Saralee G. Hillman Mr. and Mrs. David L. Kieper Mrs. Alison C. Marer Ms. Ruth A. Hodges and Mr. John Ms. Jeana C. King Mr. Elliot D. Markowitz A. LeClaire Mr. William H. Kirby and Dr. Lenore S. Kirby Ms. Magdalena Markus Mr. and Mrs. Charles K. Hoffman Mr. and Mrs. Randy S. Kitson Mr. and Mrs. William G. Martens III Mr. Jeffrey P. Holman The Kittler Family Trust Dr. Jane Martin and Mr. Stuart Z. Katz Mr. Timothy A. Hood Mr. and Mrs. Edward Kittredge Ms. Danielle Martinez Hope for Depression Research Foundation Mrs. Risa Klainguti Mr. James Martis (HDRF) Mr. and Mrs. Robert C. Knes Masson & Associates, Inc.

66 ANNUAL REPORT 2017 Mrs. Naomi K. Matsumoto Orlando Barbell, Inc. Mr. John H. Russell and Ms. Darryl Redhage Mr. John W. Huberty and Ms. Christine Mr. and Mrs. Richard J. Orr Mr. Iain Rutherford A. Mauro-Huberty Mr. and Mrs. John R. Osterhaus Saddlebag Lake Church Mr. John C. McCabe Mr. Jayson C. Owen Mr. James A. Sadewhite Mr. Kyle McCann Mr. and Mrs. Leonard J. Owen Ms. Anne M. Saint John Mrs. Suzanne B. McCarthy Palette Charitable Gifts Mr. Kevin Saka Mr. and Mrs. Harry L. McComas Mr. Ramsay Palmer Ms. Ellin J. Saltzman Mrs. Rebecca L. McDonald Ms. Ellen Paltiel John and Barbara Samuelson William M. McDonald, M.D. Mr. and Mrs. Anthony Pardo Foundation, Inc. Mr. Donald M. McFarland Mr. Jason Parker Ms. Nancy Schaal Mr. Bruce T. McGuire Mr. Hitesh Parmar Mr. Peter Scheidler Dr. Steven McLaughlin Mr. and Mrs. Russell V. Parrish Mr. and Mrs. Richard J. Schlueter Mr. Bryan McLemore Mr. and Mrs. George E. Pawlowski Anthony A. Schmidt Family Foundation Ms. Anne McWilliams Mr. John Paxton Mr. and Mrs. Jeffrey Schnipper Mr. David Melvin Ms. Megan J. Paznik Mr. and Mrs. Wayne H. Schut Mr. and Mrs. David B. Merchant PBP Foundation of New York, Inc. Ms. Joann Schwentker The Merck Foundation Mr. Jesse M. Abraham and Ms. Amy Seacoast Orthopedic Associates, Inc. MetroGistics, LLC Peck-Abraham Ms. Pauline Seeto Edward & Sandra Meyer Foundation Mr. James Perakis Ms. Emily Segal and Mr. Andrew Ellis Mrs. Sallie Middleton-Parker Mr. Robert F. Perry The David & Shirley Seiler Foundation Ms. Katarina Miehlisch Ms. Laura Petersen Mr. Denton Seilhan and Ms. Cathy Dr. and Mrs. Gary L. Mihelish Ms. Lisa Peterson Cole-Seilhan Ms. Kimberly E. Millen Mr. Michael Pitt Mr. Kishore Setty Andrew H. Miller, M.D. Ms. Danielle Powers Shapiro Haber & Urmy, LLP Dr. Jean F. Miller Mr. and Mrs. Stuart Rabner Mr. Benjamin A. Shepherd Mr. and Mrs. Paul D. Miller Mr. Kumar Rajan Mr. and Mrs. John Shields The Honorable Sondra M. Miller Mr. Terizhandur S. Ramakrishnan Mr. and Mrs. David B. Shippey Mr. and Mrs. Michael T. Mitchell Ms. Susan Randall Mr. Michel Shuherk Ms. Dianne Modestini Ms. Sharon Rappe Mr. Jeffrey M. Siegal Dr. Enrique H. Monsanto and Dr. Ms. Lindsey Rappleyea Ms. Sally Sievers Barbara Winkler-Monsanto RayLign Foundation Mr. and Mrs. William Silver Mr. Gregory Mooradian Mr. and Mrs. Somasekhara R. Rebala Dr. Matt D. Silverman Mr. and Mrs. Terence J. Moran IV Mr. and Mrs. Charles E. Reed Mr. and Mrs. Robert F. Simari Morgan Stanley Mr. and Mrs. David M. Reed, Jr. Joseph T. & Helen M. Simpson Foundation Mr. Merrick Morlan Mr. and Mrs. Ronald A. Reichert, Jr. Ms. Kathleen Simpson Mr. and Mrs. Rob Morrill Mr. and Mrs. Robert S. Reitzes Mr. and Mrs. John B. Sisk Mr. and Mrs. Loren J. Morris Mr. and Mrs. Vincent Rerolle Mr. Brian M. Smith Mr. and Mrs. Paul V. Mosher Mr. and Mrs. William G. Rhoads Mr. and Mrs. Hugh A. Smith Mr. John F. Mussman Mrs. Stephanie Ribakoff Mr. Michael C.T. Smith The Nacchio Foundation Ms. Suzette Richards Mr. and Mrs. Ronald Smith Ms. Sangeeta Naik Ms. Margaret A. Ricketts Mr. Glen D. Smythe Namanampa Trust Dr. James F. Riddle The Sosnow Foundation, Inc. NAMI - FACE of Burlington County Mr. Frederic W. Ripley and Ms. Sharon Kirby Mr. Michael A. Soyka NAMI - Saint Cloud Area The Robbins Family Foundation Ms. Margaret R. Sparks NAMI - San Joaquin County Mr. Brian A. Robbins Mr. and Mrs. Ted Spetnagel Mr. Matthew Nimetz Mr. and Mrs. Scott D. Robinson Mr. Ryan J. Stacklin Ms. Reita A. Noble Mr. and Ms. Jeffrey T. Robison Mr. and Mrs. J. Tristan Stancato Ms. Kathleen O’Dell Mr. Javier Rodriguez State Street Bank & Trust Co. Carl and Lucile Oestreicher Foundation, Inc. Dr. and Mrs. Alain Roizen Ms. Jennifer Steckley Mr. and Mrs. Timothy O’Keefe Ms. Marcella Rosen Mr. Jason Stein Mr. Henrik S. Olsen and Ms. Deborah Mr. and Mrs. The Meyer & Jean Steinberg M. Mesmer Mr. and Mrs. Michael A. Ross Family Foundation Mr. and Mrs. John A. O’Malley Dr. Harold A. Pincus and Ms. Ellyn S. Roth Mr. John Steinhardt and Ms. Susan The Order of St. Benedict of New Jersey- Mr. Joshua Rubin B. Margules-Steinhardt Delbarton School Mr. David Ruen

www.bbrfoundation.org 67 Dr. Melvin J. Stern and Ms. Merna Mr. and Mrs. Roger S. Vinton, Jr. Deutsche Bank Americas Foundation Wagshal-Stern Mrs. Virginia Vitarello DonateWell Ms. Morgan Steves Mr. Thomas Vreeland Dynegy, Inc. Ms. Georgia Stewart Mr. and Mrs. William Weickert eBay, Inc. Foundation Mr. and Mrs. Brent Stewart Ms. Roseanne Weinel Exelon Corporation Dr. Claudia C. Stewart Ms. Ann Weiner Fortis Construction, Inc. Ms. Virginia L. Stewart Ms. Christine Weir The GE Foundation–Matching Gifts Mr. Kevin Still Wells Fargo Community Support Campaign Program Ms. Marisa A. Stratelak Dr. and Mrs. James D. Westhoven Genentech Employee Giving Program Mr. Michael S. Strauss and Ms. Robin The Harold Wetterberg Foundation Give with Liberty–Employee Donations B. Klein-Strauss Mrs. Beverly A. White GlaxoSmithKline–Matching Gifts Program Mr. and Mrs. Thomas W. Strauss Ms. Susan C. White Goldman, Sachs & Co. Matching Gift Mr. Tyrone Strickland Ms. Kym Whitley Program Mr. Lee E. Strom and Ms. Andrea P. Mr. David N. Wholley and Ms. Jana Partners, LLC Trewyn-Strom Peggy O’Crowley Janus Foundation Sutter Health Ms. Cathleme Wiedenhoeft JMT Charitable Foundation Dr. Kevin S. Tait Ms. Liesl A. Wiederkehr John Hancock Financial Services–Matching Mr. and Mrs. Arnold S. Tannenbaum Mr. and Mrs. John Wiegmann Gifts Program Tashlik Family Charitable Foundation Mr. and Mrs. Nate Wiger John Wiley & Sons, Inc. Mr. Lowell C. Freiberg and Ms. Cathy Mr. John C. Williams and Ms. Joy Griffin Johnson & Johnson–Matching Gifts Program E. Taub Mr. and Mrs. Steven C. Wills Robert Wood Johnson Foundation (RWJF) Dr. Rachel Tay Richard and Lynn Wilson Fund KPMG–Matching Gifts Program Taylor Survivor’s Trust Drs. Michael and Abby Wolk Eli Lilly & Company Foundation, Inc.– TD Ameritrade Institutional Mr. David Wong Matching Gifts Program Mr. and Mrs. Robert Tekiela Mr. Morgan R. Dallman and Ms. Carolyn LinkedIn Matching Gifts Program Mr. and Mrs. Daniel Temple Woodruff Macquarie Group Foundation Dr. Patricia Thielemann Amy J. Worrell, VMD McMaster–Carr Mr. William T. Scherkey and Ms. Melinda Mr. and Mrs. Charles R.B. Wright Medtronic Global Goverment Affairs– M. Thompson Wyant Family Fund Americas Region Mr. and Ms. Bob F. Thompson Mr. and Mrs. Michael W. Yap The Merck Foundation Mr. Nathan Thompson and Ms. Tien Ho Dr. Karin Yoch Mutual of America Foundation Mr. and Mrs. Robert C. Thorne Mr. Kenneth Young and Ms. Julie Landau Nordstrom Mr. Joel C. Tillinghast Mr. Clement Zai OdysseyRE Foundation Mr. and Mrs. Glen A. Tobias Mr. and Mrs. James N. Zartman Penguin Random House, LLC Ms. Marcia E. Topel Zephyr SC, LLC Pfizer Foundation Matching Gifts Program Ms. Linda D. Tosti Ms. Cathy Zhang The Progressive Insurance Foundation– Ms. Judy Tozzi Mr. and Mrs. Thomas A. Zimmerman Giving Station Mr. and Mrs. Joshua Tripp Qualcomm Matching Grant Program Mr. Frederick J. Troendle MATCHING GIFT S&P Global Ms. Fay M. Trowbridge COMPANIES Salesforce.org–Matching Grants Ms. Shuk Tse Schneider Electric North America Mr. and Mrs. Michael D. Tusiani Aetna Foundation, Inc. Foundation Ms. Paula Tusiani-Eng Allstate–The Giving Campaign The Benevity Community Impact Fund UBS Financial Services, Inc. Ally Financial, Inc. The Quaker Hill Foundation, Inc. Mr. and Mrs. Chris Uhl American Express Foundation UBS–Matching Gift Programs Ms. Nancy Ullman Amgen Pac–Matching Gift Program United Way of Area UNIDENTIFIED STOCK AptarGroup Charitable Foundation Frank Visceglia Foundation United Way of Central Ohio Archer Daniels Midland Company Williams Mary C. Uricchio, M.D. Baird Foundation, Inc. YourCause, LLC Mr. and Mrs. Gary Usher Bank of America Foundation Mr. Ben Van Laan Bank Of The West–Employee Giving Mrs. Carol R. Van Lew Program Ms. Mary E. Vanover-Gilligan CNA Mr. Brian Vassallo Corporate Executive Board Matching Gift Mr. Duane Vermazen Program (CEB)

68 ANNUAL REPORT 2017 TRIBUTES Samantha M. Beard Dr. William T. Carpenter, Jr., M.D. Carol Ann Bee Alex Caruso Honor Tributes Emily Bellof Calvin Casalino Robert and Carol Benkeser Barbara Castellano "A" Clara Bennett Charles B. Castle A loved one David Bennett Lillie Cawthorne The Abrams Family Michael Berg The Chan Family Jan I. Abrams Stephanie Berg Kassie Chaney Lynsey Abrams Alexander Berger Bridget Charhut Anne Abramson Howard and Patty Berke Haiwen Chen and Bob Harlow Kipp Abrego Sharon Bernardini Sho Tin Chen Christine M. Addeo Isabel Berner Veronica Chen Michael Adelman Sydney Bezonsky Jesus Christ Isabella Aebly BFP Sam Coates Nancy Alain's "The Light of My Life" Anne L. Bird Karen L. Cohen Terry Pink Alexander's son Stephanie Bissette-Roark Mitch Cohen All college students affected by Shane Black Peter G. Coles, M.D. Schizophrenia Hilary P. Blumberg, M.D. Thomas B. Coles, M.D. All of the brave souls that fight Depression Camila Boccalandro Henry Conklin daily Jerome and Cora Bodkin John and Clairlyn Connolly All the good causes Mary F. Bolesta Emily C. Cook All those in need of mental health help Ann Bolton Mr. and Mrs. C. Marcus Cooper All those struggling with mental illness Michael and Shenon Bone Thomas S. Cosentino Patty Alzaibak Daniel Boorse Sylvia Cox Dean Ambrose John Booty The Crumble Family / Crumble Co. Matt Amsden Jeffrey Borenstein, M.D. Karrina J. Cummings Linda K. Amsel's ten (10) grandchildren Bryce W. Boron Michael W. Curran Amy and Joey Ray and Bird Bost Aurora Cutie Grandmother Anderson The Boudreau Family Barbara Czajka Christina E. Angelo Darren Boyd E. Daetz Anna Mentors and colleagues receiving Megan D'Agostino Samuel K. Argyle awards from the Brain & Behavior Daniel and Elizabeth Dain T. Aries Research Foundation Judy Daniels Bradley M. Arsznov The Staff at the Brain & Behavior Joelle D'Arienzo Carol A. Atkinson Research Foundation Pat Davis Janie Atlas Jeffrey M. Braun William F. Davis Shuaib Audu Jen Bridges Kittie A. Day Ben and Erin Austin Brit and Madison Shelby Day Andrew Bailey Nick Brodsky Alanna de la Pena-Bradshaw Mark A. Bailey Patrick Bromley Stephen P. Dean Andrew Bank Alison Brooks Jeff DeBono Judy Barger Paige Brotschul Lauren DeCamillis Amy Barnes Margaret F. Brown's Mother Jeffrey DeMarco Martha Barnes Sheldon Bruetsch Gianna DeMedio Richard A. Baron II Robert Buchanan Amit Desai Alexander Bartel Christine Burrows Roger DeStefano Abby Bartlett Kelley Butler James M. Diggins Dean Barto Elyse J. Butterman Kathleen Dodson Greenberg Susan K. Bass Canden Byrd Mr. and Mrs. Neal Donaldson Parker Bassel Addoits Caballero Reed Donat Mary C. Bassett David Calvin and Constance Page's Donna and Pat Andrew Bauer and Stacie Van Brandenburg Contintental Divide Ride Timothy Donohue Savannah Bay Ben Campbell Bobby Dowling John C. Bayat Elaine Candelori Meaghan Doyle BD, DF, DN, MG, NC, RN, RR and SN Victoria Carnes Elizabeth M. DuBrow

www.bbrfoundation.org 69 Lauren R. Duran Robert Gottermeier Kevin Hughes Sondra Durr Gail Grace Angela Hurtado Vishal Duvvum Kathleen Grace Kenneth Hyacinthe Joyce Dwight-Bolton Melody Grant Caryn Iber Lindsey Dyer and Chris Eginton Susan M. Green Impact, University of Iowa Angus Edwards and Renee Morita Carol J. Greenday Jenne Ingrassia Kurt and Mary Edwards Michele Green-Ferrante Louis Innamorato Shannon Elgin Madonna Greer Thomas and Deborah Insel Daniel P. Elwell Ben Grefsrud Brandon Isaacson EMK David Grier's son Ivan Dana Engle Michael and Patricia Griffin Jack Christian Engstrom Victoria Griswold Natasha Jackson Lauren M. Estrada The Guardarrama Family Lea E. Jacobs Nick Evans The Gulley Family Alana Jacoby Micah Fallon Judith E. Gunther Eric T. Jager Stephen Fast Lyla Guthrie The Jala Family Emma Fenty Parker Hall Beverly Janes Michele Fiotakis Alesia Hallmark Pratyusha Javangula Ashley Fischer and Jonathan Mabry Lisa Halpern-Berger Nicole Jedrzejko Laura Flook Bonnie and Alan Hammerschlag Richard and Sarah Jerro Scissors Flook John-Pierre M. Hannam and family John and Melissa Douglas Flynn Renee Hansen Pamela D. Johnson John Paul Foley Phyllis Hardy Ronald A. Johnson Elizabeth Folpe Bruce Harlow, Sr. and his unconditional Sara Johnson Andrei Fontes love for his three children William H. Jondrow, Jr. Drew and Carolina Forni Brenda Harper Mary Joyce's Mother Kelly Fortier John K. Harrison II John Juraska Luisa Francoeur Reace B. Harrison Mike Kachuk Elaine Frank Eric Harty Aaron Kahan Sean A. Franklin Mohammedali Hassanali Rashid Sahaj Kamdar Andrew B. Freeman Emily Haussler Sol and Gloria Kamen Jacob Freiberg Ryan Haworth Alexa Kamm Alexis Fricke Lee Hayner-Evergreen Tim and Liz Kane Mazella B. Fuller, Ph.D., M.S.W., LCSW, CEDS Patricia Hays John Kania The J.B. Fuqua Foundation, Inc. Bernard and Mary Healy Isabelle Katsilis Michael D. Furay Brett Hebert and Guara Saini Joel and Elinor Katz Michael J. Gascoigne Cathy Hebert Helga Kawesch Anndee Gates's son Jonathan T. Hebert's family (Mom, Cathy, Kari Kelly Joan Gates Dad, Peter, Mabel and John) Kelsey's Birthday Theodore M. Gault Meryem S. Hebert Heather A. Kennedy, M.D. The Gehsmann Family Peter H. Hebert Mary W. Kenny Christian, Erinn and Greer Geideman Ben Hendricks Kerry and Norm Theresa George Jason and Tisa Herndon Hong Kim Patrick Giles Emily Herrick Kimberly & Shauna Kari Gilpatric Andy and Kristi Higham Wade Kimbrell Steven W. Ginsberg Merrill Higham Chris King Diana Giraldo David P. Hoffman's sister Shu B. King Andrea Gladstone Kenneth A. Holihan John D. Kirk Tigraw Glickman John B. Hollister Cameron K. Kirsic (King Khaya) Mark R. Gloss, M.D. Will Holmes Chloe N. Kirsic (Chloe Superstar) Julie Gold Alexandra Holterman Michael and Lisa Kirsic Suzanne Golden Hope's Cure Doris M. Knapp Amanda Golding C.J. Hopkins Gabriella Knopf Gonzales-Vigilar Psychiatric Services Easton Hoyt Graham Knopf Russell and Kate Goodburn Heather Hsia Steven Korngut

70 ANNUAL REPORT 2017 Karl F. Korpela Elizabeth Mansky The Murray Family Joseph J. Kranyak James R. Manzo Grace Nagaur Rob Krasny and Sasha Ginsburg Natalia Mariscovetere Christopher, Jaclyn and Michael Natale Susanne T. Krehel Casey Marquis Nataline Matt Krishnamachari Elizabeth Marrinan Dr. Guy A. Navarra Howard and Shelley Kristol Paul V. Marrone's grandchildren Rukhsana Nawaz Danielle D. Ladensack Chandler Martin Jimmy and Ilana Neenan Chace Laffin Maryam Beth Nelson Dr. and Mrs. Derrick Lai William P. Mathieu Erich Nerger Sheldon Laing Carol Maurice Sherlene Newton The Laitman Family Michele Maurice Brian Ng Laurie Lamb The Maybank Family Carol Nichols David Lansen Mary E. McAward Rubye E. Noble-Evans' brother Nathan Lape Alexander McCabe-Fox Robin Nobling Kyle A.B. Lapidus, M.D., Ph.D. Eric McCaffrey Maura Nolan The victims of the Las Vegas Massacre Allan T. McCall Joe Norton Jennifer Laschen John and Molly McCreary Arron N. O'Callaghan and Sean D.O. Smith Paul T. Laun Michael T. McGuire, M.D. Rowan M. O'Flanagan Laura Jeff McKnight Debra A. Ohlson Andrew Lee Kate McMahon's Mother Micah Ohno Moonju and Myung Lee Kristina McNamara Joshua D. Okun Buzz Leffelman Tim McVey Jack O'Neill Jessica Leffelman Patrick McWilliams Anita Or Kevin Lei Max Mehlman Mr. and Mrs. John Ortiz Marvin Leichtung Ingrid Mesa-Gibbons Nieves A. Ortiz Avery Lemons Adam Messinger and Liz Sadler Patricia Page Sam Lerer Bradley Meyer Chuck and Susan Palmer The Lew Family Clayton Meyers Jennifer Pamerleau Jason Li Daniel Michaels Lisa A. Pan, M.D. Libbets Mr. and Mrs. Anton J. Michelich Papi Stephen A. Lieber Sarah Rose and Jay Mikelman Dr. Herbert Pardes and Dr. Nancy Wexler Kara Lilliestierna Christina Miles Cathy Parker Pearl A. Lindenbaum Kate Miles J. Megan Paul Madeline Lindgren Gregory Miller Paul (Heather Mushock's brother) Dr. Ya-Ling Liou's patients who have also Luke and Kaylee Miller Lester Paznik been her teachers Marissa Miller Dr. Arthur Peck Susan Lipps Robert W. Miller Tim Pecora Arlene Litovsky Keith Mills Maureen Pelchar Rhonda Liu Kimberly Roth and Nathaniel Mills, Jr. Ronnie A. Pellacani The Lord of Knowledge and Honor Tina Minaya Rudy Pelletier and Politimi Nasiakos Kelsey Lutz David Mischoulon, M.D., Ph.D. Eva Pelliccio Daniel Maahs Christine D. Montiel Daniel Peluso and Eva Hahler Sharon MacDougall Liam Mooney Joel M. Penny Barbara Mach-Oleksak Michael Moore Heather Perrigo Omarah Macias The Morais Family Jim and Lisette Perry Dana V. Maggi Amielle Moreno Mackenna Perryman Justin Magleby Elizabeth S. Morningstar C.M. Peters Robert Magosi Karen A. Morris Elise Petersen Dr. Thomas Maher Joyce Morrison Daniel Peterson Karrie Mahoney Robert and Ornella Morrow Mark Peterson Karen Maki Judith Morton Ellen Petrovich Carole H. Mallement Stephen and Rebekah Morton Beatrice Phear Robert Malone James P. Murphy Charles Piechoski Milton and Tamar Maltz Patrick T. Murphy The Pinkham-Oak Family Mary Manier Bill and Dee Murray Marie Piper

www.bbrfoundation.org 71 Jonathan Pitkow Mark A. Satterthwaite, M.D. Laura Terio, MSW, LCSW Plexdev Johnna T. Sauro Elfa Ting's loved ones Carolyn A. Plumer Kai and Malia Schmelzer Eliseo Tirado Nina Poe Samantha Schrock Catherine Tokman Michael Polansky Solco Schuit Howard Trachtman Jeanne S. Porter Katrina Schut Evan Traiger Andrew Potocko Julia Scullion Marta Trawicki Kali Poulin Anthony and Theresa Selvaggio Zofia Trexler Ron Powers Sarah Sexton The Trott Family Marla S. Press Shannon and Sookgi President Donald J. Trump Purdue Rivals Message Board The Members of the Shenandoah Club Paula Tudorof's brother DeMarko Quarles Lilian Sicular Emily Turner's family Kit Quarterman The Sifuentes Family Jaclyn S. Underwood Jimmy R. Dr. and Mrs. Mark Silver The wonderful participants at the Rachel Firecrow Silvernight University of Chicago Booth School Steve Radgowski Gurwinder Singh of Business Arthur J. Radin, C.P.A. Jill Sirulnick Martin Ureel Lindsey Rappleyea Kristalin Sisler Vijayaellemma James (Joe) J. Rataiczak III Isobel Slomowitz Justin Vitarello Leigh Rayfield and Aaron Gahr Shirley Smit Michael Vollmar, M.D. Jennifer Reed Brad Smith and Robin Oliver Katherine Wagner Renee's Mom Glen M. Smith Kathleen Walker Michael Reuben Richard and Sue Smith Robert R. Walker Brad Reuling Shane Smith James Walker's Sister Steve S. Rice Kathryn A. Snow, LCSW Jennifer Ward Catherine A. Riley Kai Southard Betty Waters-Terrell Ken Riner and Shirley Benzley Alan Spandorf Ray Weaver Haley Ritger Carlotta Sperry Sharon Weinberg The Geriatric Patients at Riverside Sara A. Spowart Robert and Frances Weisman Behavioral Center Amber Macho and Brendan Stancato The Weiss Family Min J. Ro J. Tristan Stancato Sam Welle and Grace Davitt Robin and Debra Roberts Kimberly Stancato Rodney Wells and family David Robertson Jeffrey and Sandra Stankiewicz Jeff Wester Carolyn B. Robinowitz, M.D. Dr. and Mrs. David J. Stanley Siena Weston-Delaney Alex Rodriguez, Jr. Adrian Stec Chris and Stephanie Wharton Carmen Rodriguez's Older Brother Nancy Steele Mr. and Mrs. R. Graham White III and family David Rodriguez Ed Stephenson Perry White Pamela Rogers Matilde Stephenson Trammell Whitfield Amy S. Rose-Beresin Brody Stevenson Aaron Williams Mable G. Rose-Beresin Jean L. Stone Kyle Williams Sally Rosenberg Lee Stover Terrie Williams Ryan and Michelle Ross Barbara K. Streicker Zelda Williams Faith Rothblatt Glen Suleski Brad and Ruth Williams-Wei Ian Rousso L. Sullivan Noelle Wilson Gregg Rubin Ryan Sullivan Wish-a-Mile 2017 Riders and Wish Robert Ruck and Maggie Patterson Eliana Sur Receivers Alex Ruppelli Melissa J. Surber and Sharon E. Bader Ria Wolf Chase Rushlow Janet Susin Melissa Wone Amber and Kim Russo Jesse Sweeney Montana Woolley Ryan (Best big brother and son) The Swinton's Wedding Guests Judith G. Wortman Wonha Ryu Sy Richard Wright and Sally Frankl A.J. Safi Tom T. Xander Sienna Saint-Cyr Charley Taggart Mike Yamanaka Mary C. Salpukas Noa J. Talmor Victor Yamaykin Glory A. Sandberg, M.D. Clif Tennison Andrea Yates

72 ANNUAL REPORT 2017 Alberta Yearout Dr. Tim G. Baliven Adam R. Bodjack Adam Yeoman and Rhian Marianne Banerjee Sid Bogin Harrington-Yeoman Robert P. Banghart Kirk Boise David Yocom Samuel C. Banks Gertrude Book Julie Zaiontz David Barazani Sandra K. Boothe Jordan and Ashley Zaslav Barbara Donald Boring Alex Zeigler Erin E. Bardwell Gail M. Bornick Andrew Zhu Dorothy G. Barraclough Jonah Bowman Terrence Barraclough Daniel Boyce Memorial Tributes Scott R. Bartlett Alison Boyer Tom Bartus Kent Bradley A loved one Eliot M. Basalone Sarah Bradley Richard (Hil) Hilstad Lee Abbott Brian A. Bass Eric Brady Anthony F. Abbruzzino Orca F. Bass Andre Brassard John (Jed) Bryden Abrams Albert Bassano Carolyn Braudaway Marc D. Abrams Abigail Bassett Angela Brayer-Wilson Elizabeth Adams-Addorio Nicholas (Nick) D. Battis Mildred Brayman Carlo A. Adan Mary Battle Christopher D. Brehl Clay Adler Dr. Michael Bauer Concepcion Breslin David Airth Kelly Bazuaye Barbara L. Brief Nicholas R. Albers Meredith W. Beck Mara Brightstar Tony Albert Ann Beckett-Herring Virginia Britton Connor Allard Lawrence H. Bell, Jr. Catherine A. Brodie Janice M. Allison Stephen H. Bell Hera Brody Trafford Allpass William D. Belter Lois Brooks Tom Allread Chester C. Bennington (Linkin Park) Reese W. Brown III Ernie Alonzo Blake Bergers Bruce Brownlee Nadia M. Al-Tabaa Jonathan Berlin James H. Buchanan Helen E. Amatangelo Vincent Beronia Selma Buchsbaum Eric E. Ammann David S. Berry Edward G. Buckovich, Jr. Vincent S. Amoroso, Jr. Gaylord L. Berry Dean Buell Carole L. Anderson Kurt Bertram Aleth C. Buenconcejo del Prado Debra L. Anderson Barbara Berzin-Rasmussen Toula D. Buhrman L. Ronald Anderson Karla Bester Derek G. Buickel Philip D. Anderson Brian A. Bezonsky Matthew T. Bukin II Robert (Robbie) C. Anderson III Deepak Bhasin Walter W. Bundschuh Silas E. Anderson, Jr. C.J. Biancalana Peter R. Bunning Reece Andrews Ken Biddle Dan Bupp Christopher Andrusz Jack Bigelow Chantal M. Burke David G. Angelini Stephen J. Binder Colleen M. Burke Carl C. (Chris) Angell Birgitta William L. Burke III Lucille Aroosian Brad Bishop Bobby K. (Kemal) Burnley Jeffrey Q. Ast Michael J. Bishop Bernadette R. Burns Nancy Atwood Shaun Biss Robert W. Burton Lynn D. Avery Margie Bivin Francis Byerley Christopher J. Awn Dr. Morton Black Winnie Byerley John J. Awn, Jr. Andrew Blackton Sandra Calabrette , Ph.D. Henry J. Blas William Caldwell Mitchell Badler Constance A. Blazy Richard G. Callahan Reginald T. Bahlinger Nicole Blecher Victoria (Torie) Susan Callahan, Ph.D. Gina M. Bailey Heather A. Bleick Sally Cameron's mother and other Jeffrey Bailey Greer Burrows Blitch loved ones Gregory T. Bak Ray M. Blum Aeric G. Cannon Anna Balek Marcia R. Bobal Danny Capizzi Scott Balgemann Charles F. Bodden, Sr. Isaac Cardona

www.bbrfoundation.org 73 Gunther G. Carle Benjamin S. Custer Julia A. Drury Jeffrey T. Carlton Elizabeth H. Custer Lorraine Dryden Paul R. Carman Edward I. Daidone Mary Drzal Joseph Carothers Richard G. Dalcourt Kyle DuBose Olivia Carver-Marconi Scott D'Alfonso John M. Duffy Richard M. Casey Eva Dalkoff Christopher R. Dugan Dwight D. Cassidy Colter Dallman Elisa T. Dulay, M.D. Mary Camille Casson Richard D. Daly Stephane R. Dupont Suzanne L. Castellani Steven Dame Steven H. Durchslag Andrew Cella Stanley F. Dann Alan Dutka Michael Cerone Vincent A. Dann Rona Dutton-Long Joyce Champion Tony F. Daugherty Dr. Stanislaw Dyrcz-Freeman Alice Chase Dave Carol Ebersole Brenna Chastain Charles (Chuck) Davis Sean T. Elkind Christopher Chastain Elizabeth Davis Craig Emery John Check Wayne Davis Dr. David M. Engelhardt Patricia Cheney Carter L. Davison James R. Eoff Dale R. Cherney Lillian Davison Jerry Epton Bradley (Brad) Garner Chesshir Janice Day Paul J. Esposito Micah Chiotti Kayann Day Catherine A. Etier Allison A. Chlan-Fellner Erwin D. de Vlas Justin B. Evarian Andrew S. Christie Rachel M. Dean Marian (Molly) Peabody Everdell Ann V. Christie A. Louise DeAngelis Gene S. Facey Gary (Bud) Christy, Jr. Kat Deaver Clem J. Faggionato Nicholas V. Ciriello Douglas H. DeFreest, Jr. Rachel Faires Ruth G. Clark Kathleen R. Degen, M.D. Alvina Faith Diane Clarke Mia DelPrince Leslie E. Falzone Philip J. Clements Kenny Demming Mark W. Farmen, Ph.D. Dolores (Dee) M. Cohen Ryan D. DeNieu Brent Farmer Leonard N. Cohen Charles R. Deremo Garrett R. Farr Nathan Cohen Katherine Deschner Joyce L. Farrell Ronald S. Cohen Harry Detwiler Matthew J. Fee Maribel L. Colby Henry (Hank) J. Deutschendorf II / Seymour Feinland Timothy J. Colebeck Hank's Hope For A Cure Jessica Feldman-Hehn Dr. William L. Coleman Dr. Dan Deutschman Alec Fentum Tiffany M. Collins-Canas Brett G. Deyo Armand H. Ferland Katie Collinsworth Jack Dickerson Mary L. Ferrero Louise O. Colwell Dustin M. Dilley Frederick A. Findlen, D.M.D. Colin G. Connolly Dustin Dishno Sherry Fingerhut Ryan J. Cook Kenneth Ditzel Kelli A. Finkel Chris Cornell Brandon Dixon Catherine Finn Lynn M. Correia Jonathan E. Dixon Fred Firestone Diane Cory Rachyl Dockery Lucia A. Fischer Wilson Cory Mildred R. Dolce Carrie F. Fisher Bradley T. Couch Diana Dombecki Jonathan J. Fisher Donald F. Coursen Senator Pete Domenici Colleen Fitzgerald Darin Couter Jim Donahue Margaret M. Fitzpatrick Alec Cove Virginia Donnell Raymond J. Flood, Jr. Christopher Cowan Christopher J. Donovan Trocar Flook Darrell H. Cromer Tupper Dooly-Webster Sean M. Flynn Jacques Crouzet-Pascal Tamara (Tammi) Dorman-Sanford Thomas B. Flynn Phyllis Cupples-Morgan Herman O. Drabenstott Helen T. Foley Adam P. Curatola Rachel L. Drabenstott Jessica A. Forbes Joan (Joanie) M. Curtin Nancy J. Drevo Larry Ford Jeffrey N. Curtis Sandra G. Dreyfuss Joan Forster

74 ANNUAL REPORT 2017 David T. Foster Bertha A. Greenwell-Drury Daniel G. Hinden John T. Foster Matthew J. Gregory Karyn Hirst Doris Carrie Ann Franks Leo Grieben John E. Hoagland III Lemmull (Todd) R. Freer IV Megan R. Grigor Jon T. Hoff Irene Gross-Bank Tristram C. Hogben Harvey Friedenberg Joyce J. Gucciardo Mark K. Holl Jason C. Frisco Carmen Y. Guerra Patricia (Patsy) G. Hollister Christopher Furay Peter L. Guerra Rick G. Holtz Mary Gallagher Suzanne Guerra Hannah (Ann) Holzman Norma Garay George J. Guida Dr. Philip S. Holzman Duane Gardner II Thomas S. Gumport Kari Hoover Jane F. (MacRae) Garrigan Peter A. Gunness Justin Hornsby David Gatti Amanda G. Gurley Joseph C. Horowitz Florence Gaydos Taylor L. Guthrie George C.B. Hosley George Gaydos Robert Haber Michael T. Houtchens Phil Gaydos Michael V. Hager John D. Huberty Jeffrey C. Gebhardt Julia A. Hagood-Poindexter Clarence T. Hudson Matthew Geishauser Barbara Hale Rennie E. Hughes Kara L. Gelfand-Bartoli Keith Hall Patricia J. Hutchings John T. Gelke Larry Hall Dr. Richard Hymowitz Frank Gentile Renee Halpern Jed C. Immel-Brown Marilyn Genzer Sean P. Hamann Jane Irwin-Malinoff Rita Geoffrey Henry (Hank) Hanau Shiz Ishikawa Dr. William F. Geserick Matthew J. Hardin David N. Isler William Getz Wes Hardin Joseph H. Israel Robert A. Gibb Robert Hardman Jeanne Jackson Steven H. Gibson Vaughn R. Harp Lynnette J. Jacob Reverend Dr. T. Edward Giles James S. Harris Hedwig Jacobites Ted R. Giles John K. Harrison Dr. Peter W. Jacobsen Ryan C. Gilroy Rog Harrison Prem Jajoo Robert Gimprich Stewart G. Harrison Jack James Wendy A. Giurleo Brent A. Harshman Sabrina I. James Brian D. Go Harriet M. Hart Joseph Jefferson Fred Godert Stanley Hart Barbara J. Jenefsky William J. Godsil Victoria L. Hart Ernest (Ernie) B. Johnson Laura Goedeke Julie Harter Hannah Johnson Eileen Gold Edith Hassman Justin Johnson Bradley Goldman Brandon Hauser Michael D. Johnson David Goldman Ruqia Hayat Ronna E. Johnson Janice Goldman Kevin W. Haynes Ryan P. Johnson Eileen Gordon Fredericka (Billie) Wilhelmina Aldred Susan J. Johnson Ethel G. Gordon Payton Hazard Terry R. Jones William T. Goss Kevin Heald Zachary Jones Michael J. Gould Kevin J. Healey Kim Jong-hyun Adam J. Grainawi Peter F. Heggs Joan B. Judd Brenda Gray Jimmy Hehir June Linda Gray-Popovich Itzhak (Isaac) Heifetz Andreas (Dre) P. Kahan David E. Green Bradley R. Heilman Douglas J. Kaiser Bradford A. Greenberg Betty Hellander Rebecca S. Kalbfleisch Daniel Greenberg Richard T. Heller Lawrence E. Kalom Mary Greener Shane A. Henderson Sean B. Kamp Mark J. Greenlee Gilberto Hernandez-Gonzalez, Jr. Daniel D. Kane Alan Greenstadt Rachel Herrick Robert J. Kannenberg Lee K. Greenwald Andrei A. Higgins Florence Kaplan Rena Greenwald Melody Hill Steven Karp

www.bbrfoundation.org 75 Savannah T. Karten Victor M. LaFata Yunfang Lu Walter Katerynczuk Pratima H. Lakhani Paul E. Lucas Claude R. Kaufman John Landmesser Ronald L. Lucas David Kaufman Melissa A. Lanier Daniel R. Luck Bachar G. Kayal Jeffrey S. Lanoue James M. Luerich Daniel R. Keegan Guy Lanquetot William C. Lund Thomas A. Keeton Matthew Larkin Helene Lundak Thomas M. Keiper The victims of the Las Vegas Massacre John Lupton Dorothy Kemp-Schmoltze David Lau Bassel Lutfi Michael (Misha) B. Kendis Jenna R. Laubach S. Lutovsky Erin E.A. Kerdus Dickman Robert E. Lauer Shirley S. Lynne Wajahat Khan Sara Laurenzo's sister Barbara Lyons Ziaullah Khan Henry E. Lavoie Lena Machado Rashidul H. Khan-Shiply Lucille M. Lavoie Noel A. Machado Brian Kich Jerome (Jerry) C. Lawrence Vincent V. Magi David T. Kidwell, M.D. Kerry P. Leary Roman Makuch Del Marie King Arthur E. (Artie) Leavy, Jr. Kirsten Malmstrom Rita I. King Joseph A. LeBlanc, M.D. Carol Manful Sherry King-Burke Jeremy LeDuc Merrill M. Manning III Drew Kinsey Muriel Leff Georgia Mantell-Ziegler Jill A. Kirby Justin Leitner Mitch Marantz Kathy Kirsch Edward Lester Philippe Marchiset Bryan Klausner Jorie Lester-Mark Roland Marchiset Monica Klein Dr. Jack Letts Barbara M. (Bunny) Maren Evin Kleinganz Andreya (Drey) Leuer Alan G. Marer Jenna Knickerbocker Beatrice Levin Elliot Markowitz Max Knickerbocker Lee S. LeVine Lawrence V. Marra Jordan Knight Michael S. Levine Adam J. Marron Robert Knight Willow Levitt Allan C. Martin Michael Knutson Gloria L. Levy David D. Martindale Michael Kocmond Dr. Joanne Levy Nicolás Martinez Christine Kohlstedt Suzanne Lewandowski Elizabeth Martino Peter C. Kohn Erma Liberty David J. Martorano John N. Kolman Jacob Lichtenstein Dolores Massey-Healy Richard L. Komray Constance E. Lieber Michael D. Mattoon Arty Kononchik Mary M. Lieber Thomas Matye Diane A. Koskinas James D. Liechty Travis Matye Melvin H. Koster Martha Limberg Maureen Cynthia Kozak Jamie S. Lince William J. McAdams John B. Kramer, Jr. Frances E. Link-Matthews Karen Anne McAllister Austin Krider William L. Lippa Wendell McAllister Mark Krieger Lisa Kevin McAward Joseph J. Kroepil, Jr. Lina Litinskaya-Weinbaum Christopher McCall Mennetta C. Krueger Richard E. Little Karen Doughty John Kruger Ronald E. Ljunggren John G. McCarthy Michael J. Kruger Donna M. Lloyd Michael R. McCarthy Jason Kruse John (Jack) S. Logue II Ryan McCarthy Kendal Kucera Mark E. London Lena J. McCleary Ratna K. Kudaravalli Peter Lortie Skye McCole-Bartusiak Marc A. Kuder Ernest Loska Trevor S. McCoy Olive Kuhl Beverley Ann Lott Judith A. McCue Matthew P. Kurtz Victor G. Lottmann Kathleen A. McDonald-Jones Ellen Lacey Basil L. Loudas Janette McFadden Chester G. LaCroix Anna Lowenberger John McFadden Sadie E. Ladick Joanna Lowry Sean McGarvey

76 ANNUAL REPORT 2017 David McGibbon, Jr. Evan M. Nakashige Erin N. Pigney Paul J. McGovern Thomas A. Navarra Colin Pitt Andrew McGowan Conner D. Neely Leonard Polisar Kathleen (Kathy) E. McGowan Lisa Nelson Bruce Poole Shea McKenna Richard E. Nelson Adele Porvancher Susan McKuhn Daniel P. Newberry Lee Porvancher John R. McLain, D.C. Jeffrey Wen Fong Ng Wu Mollie Porvancher Summer McLellan-Shoats Jane Nolte Pauline Porvancher Patrick McMahon Walter Nolte Elizabeth M. Posa Brian J. McVey Harry Nudler Patricia Potenza Mina Mead Russ Nugent Mary Prebor-Quintero Joan Meehar Judith A. Nussbaum John Prentiss Jeffrey M. Mercer Christopher O'Connor Marti Price Julie Meshel Brian O'Daniels Oliver M. Priceman David Meyer Oliver Odner Karen Prince Bradley J. Michel Brian S. Ogden Robert E. Prows Apphia Michelich Erin M. O'Keefe Peppino Puleo Ronald Michelich Susan Okun Matthew R. Radula Christopher F. Miehlisch Aaron D. Olander Emil B. Rafael Cassie Mikols Hadley Olcott-Garrett Sidharth Ramakrishnan Bernice "Bunny" Miller Kerry E. Shreve Olivier Raymond Rando Lori Miller-Levine Cameron R. Orr Anthony F. Rankin Edwin L. Millet Clyde R. Oser Sam Raskin Candice E. Mitchell Stanley Osher, M.D. Edward (Eddie) D. Ratcliffe Kyle J. Mitchell Tom L. Otto Hazel Raths Sharon Mitchell Erminia P. Pagano Devin P. Rattigan Patrick Miu Barbara W. Page Cassandra (Cassie) N. Ray Ana L. (Toshi) Miyashiro Jeanne E. Page Everette Anthony M. Razziano Linda Mobley-Watson Andrew Pappas Evan G. Rea Neil Molberger Francis R. Parajon John Reason John Molitor Devon Parent Louise J. Recchia Darren Monahan Niranjana K. Parikh Joseph Reddock Gregory A. Monk Dr. Gary Parker Lynda Reddock Raymond J. Monnot Josiah E. Parker III Rebecca (Becky) A. Rein Juan (Joji) Maniquis Montelibano Kathy Parker Sheldon M. Rein Irene Moran Sureka Parmar Grandpa Reiter Laura F. Morlan Paul A. Parris Marci S. Reller Michael P. Morozuk Silas Parry Marie K. Rendon Mary Morris Beverly Paschal Mark S. Reuling Sharon Morris Pratik Patel James D. Reynard, M.D. Hughes G. Morton Alexander V. Patenaude Dr. Sun Hong Rhie Lee Moskow Marketa E. Patterson Kenneth A. Rice Richard D. Moszkowski Aubry Pavlik Jeanne H. Rich Patrick R. Muldoon Kathryn M. Pendleton Caasi A. Rich-Vogel Andrew (Andy) L. Munson Sylvia Perecman Dorrit L. Rippchen Wyatt L. Murchison Sydney L. Perkins Ellen Ristow Lawrence W. Murphy Robert E. Perkinson Jennifer B. Ritter Monica Murphy David J. Persik Barbara Robbins Charles L. Murray, Jr. Gregory S. Persik Jonathon J. Robbins Paula Mursell David J. Peterson Trandl Robbins Marc R. Myers Timothy T. Peterson Florinette (Little Flower) Roberge-Schon Roberta L. Myers Raymond Pfeiffer Jacob (Jake) A. Roberson Sarah Nack Lynn Phillips Lauren Robinson-Kieves Shilpa Nagendran Parker E. Phillips II Devin Robledo Dr. B.N. Nagnur Sybil Pierce Ryan M. Rodgers

www.bbrfoundation.org 77 Sheri Lyn Roe Gary S. Sevitsky Joe E. Steakley Mary Roeder Karen Seykora Ronald Stedelin David Rogers Chloe Shannon Mary Steele Doris Joy (Dottie) Rogers William Shannon Mike Steichen Elizabeth Rolland Jean Shapiro Brandon T. Steimel Henry J. Romney Conor F. Sharpe Barbara Steinfeld Brian Rorick Jed Shen Lyla Stern Tommy Rorick Edwin N. Sherr Madalyn K. Sterrett Matthew Rosen Harriet Shetler Stevie Sydelle Rosenberg Sylvia Shick Kathryn Stitz Alan G. Ross Kathleen (Katie) M. Shoener Evelyn Stoddard-Crane Mitchell S. Ross Jakob W. Siccama Peter Stojsavljevic Kevin E. Rossell Richard C. Siefert William Stone Christina Rossi Stefan Sigman Amy M. Strahan Janet Rossi Rebecca A. Sikora Brian L. Stringer Ann Roth (Mrs. Donald I. Roth) Benjamin L. Silver Mary J. Strub-Caulkins Matthew S. Rothman Geraldine C. Simeone Hans Struth Julien F. Rouse, Jr. Duncan N. Simic Kenneth E. Stutzman William F. Rosseau David B. Simpson Michael D. Sugarman Kevin Rubinstein Jeff Singer Alex (Chip) G. Sulik, Jr. Chris Rudder Ranjit Sinha, M.D. Carol L. Sullivan John (Jack) R. Ruder John T. Sinnott Steven C. Sutton Mark Ruhaj Toni M. Skifstad Dorothy E. Suver Donald J. Rully Pamela B. Sklar, M.D., Ph.D. T.C. Swafford Charles C. Ruotolo Thomas M. Sklios Patricia Swanjord Patrick J. Russell Carol R. Smith Jeffrey G. Sweeney Mary Russo Edmund Smith Joshua J. Sweeney Linda Sacks Edward J. Smith Andrew Taddy Zachary Sallaway-Schneier Gary J. Smith Katrina Tagget John R. Sans, Jr. Gregg R. Smith Betty R. Tarantola Lourdes M. Santos Greig Smith Cindy L. Taylor Michael Satran Peter E. Smith Wiley E. Taylor Kerri N. Saunders Tyler Smith Bruce G. Taymor Linda Schamp John C. Snowdon Gerald P. Tchir William Schatz Warren Solomon Thalia A. Tellez Brian Scheessele Hanan Somali Thomas D. Thacher II Terry Scheffler Charles Sommers Kelsey M. Thomas Betsy Scheld Chris E. Sorensen Camilla (Cammie) L. Thompson Victoria Scheld Kelly L. Sorensen Maria C. Thompson Scott W. Scheurer Tim Soule Barbara Thompson-Brindle Barbara Rose (Gladsden) Schindler Geri Sowa-Karol Ainsley R. Thornhill Reid Schmidt Susan K. Soyka Patrick Tierney Helga Schmidt-Gengenbach Timothy Spada Nick Tindall Sarah Schoenthal Louis A. Spadaccini Kiwa Toomer Lee Schoolmeesters Russell Sparrow Steven M. Toro Richard B. Schreiber Cynthia A. Sprouse-Wright Filippo V. Toscano S. Charles (Chuck) Schulz, M.D. Ronald W. Staab Leanne Townsend Rob Schumacher Kevin C. Stack Mario A. Tozzi, Jr. Michael L. Schwartz Samuel R. Stack Frances S. Trager Peter Scontras Ian J. Stancato Morris Trager David J. Scott Alicyn Stander Jacqueline (Jackie) S. Trantham Rich Searle Frances B. Stanik Samuel P. Trice Briston J. Segraves John A. Stapleton Susan Trochesset-Havran Paz Selo Mary Louise Stauffer-Bray Clarence (Bud) Trombly Werner A. Selo Clarence Steadman Richard Trommer

78 ANNUAL REPORT 2017 Jeffrey S. Trott Brent Willard Christian Truong Gregory S. Williams Donald Trybula Robin Williams Michael Tuhy Sylvia Williams Lucy Turcotte Margaret Wills Sussie Tyrrell Richard K. Wilson Robert D. Uhl Holiday P. Wilson-Camhi Richard L. Underwood Betty J. Winberg Anthony W. Vagnoni David Winter Gerald Van de Bruinhorst Douglas Wistner Stephanie L. Van Gundy Terrance D. Witherill Steven Van Lew Cheryl E. Wolfe Charles Varkoly Theresa L. Wolff Christopher C. Vella Farrell J. Wolfson Benjamin B. Vendeland John M. Wolverton Keith A. Vinskofski Ivan Wood The 32 lives of those Hokies lost at Virginia Evan Woods Tech on 4/16/2007 Laura Wren-Polansky Kurt A. Vogt David Wussler Dean Voukelatos Matthew Yaghoobian Alexa (Lexie) L. Wach Sally Yates Quartense E. Wade Diane L. Young William F. Wagner, Jr. Shervin Zahedi Barry M. Walden Peter W. Zartman Don Walsh Jack Zaugg Justin Z. Wang Maria Zeier Eric R. Ward Claire Zeleznik Betsy A. Watkins Barry L. Zimmerman Morton Wax Richard M. Zirlen Stephanie Wayment Luis E. Zuritaa Leone H. (Wisneski) Weber Mary Weber Imaam Wehab Daniel Weiss James C. Welbourne Darren Welch Catherine Welford-Delva Michael Welsh Thomas J. Wendt Timothy R. Wentz Susan L. Wessman Michael Westforth Heidi A. Westhoven Robert Wetzel Phyllis Wheatley-Cameron Matthew W. Wheeler Austin R. White Harry Whiteman Sir Aaron Marcus Whitfield Eamonn D. Wholley John A. Wiederkehr II Carol Wiedower-Walls Michael G. Wieman Zack Wiener Cathy (Chick) S. Wiggins McCulloch Bowers

www.bbrfoundation.org 79 TEAM UP FOR RESEARCH

$25,000+ FIGHTING MENTAL ILLNESS IN MEMORY OF CHESTER EVERYDAY HERO IRONMAN TRIATHLON BENNINGTON - LINKIN PARK Coastal Community 7TH ANNUAL LET THE SUN Darren Del Priore Melissa Wilke Foundation of South SHINE RUN/WALK Montvale, NJ Düsseldorf, Germany Carolina Kathy & Kurt Robbins Charleston, SC Cold Spring, MN NAMI - EASTSIDE SUPPORT MAKEANEFFORT: 2017 NYC GROUP MARATHON HAIWEN AND BOB HIKE FOR MENTAL HEALTH Dr. Tom B. Coles John Marangiello Haiwen Chen Leo Walker & Tom Kennedy Gross Pointe Woods, MI Morganville, NJ Baltimore, MD Houston, TX RUN FOR RESEARCH NOA TALMOR'S BAT MITZVAH HEADSTRONG CLUB $10,000+ Lindsey Rappleyea Talmor Family Mira Costa High School Bear, DE San Jose, CA Manhattan Beach, CA CHRISSY'S WISH Linda & Mario Rossi VIRTUAL STRIDES ROBERT BUCHANAN ART SHOW HIKE HAPPY: 2,190 MILES FOR Dix Hills, NY Mark Petrillo Megan Buchanan MENTAL HEALTH Melbourne, FL West Plains, MO Lynsey Abrams HORIZON GROUP PROPERTIES Eldersburg, MD Gary Skoien & Connie Dyer ZELDA'S BREATH RPG CROSSING FUNDRAISER Rosemont, IL Zelda Williams Mark Englehardt HR NETWORKING DINNER Internet Campaign Ottawa, Canada Martin Fretwell MICHAEL MATTOON Lakewood, CO GOLF OUTING $1,000+ SEARLE'S SPECIAL Kathleen Mattoon COMMEMORATIVE SHIRTS HUMBLE BUNDLE, INC. Gilberts, IL AGORAPHOBIC TRAVELLER/ Tommy Searle San Francisco, CA STORIES FOR GOOD Internet Campaign TEAM DANIEL: RUNNING FOR Isabelle Marantz LULAROE FUNDRAISER RECOVERY FROM MENTAL Haydenville, MA TALONRO GAMING Erin Adams ILLNESS Internet Campaign San Clemente, CA Drs. Ann & Robert Laitman COLLIN'S HALF-MARATHON FOR Armonk, NY & Port Washington, THE BRAIN TWITCH TV FUNDRAISING NOSTALGIA CRITIC NY Collin Dimler Gibi Asmr Doug Walker Stone Ridge, NY Internet Campaign Internet Campaign $5,000+ DAVE GREEN MEMORIAL GOLF $500+ THE ORDER OF ST. BENEDICT 2ND ANNUAL TIMMY SPADA CLASSIC OF NEW JERSEY MEMORIAL GOLF CLASSIC John Hagerty 2017 ANGELL OPEN TENNIS Delbarton School Myke Furhman Glen Dale, MD TOURNAMENT Morristown, NJ Sherman, CT Chip Angell DRUM AGAINST DEPRESSION Brooklin, ME ZASLAV WEDDING ANDRE'S KILIMANJARO ASCENT Kevin M. Lois Ashley and Jordan Zaslav Andre Stapleton Corpus Christi, TX DELILAH ELLENBERG FIGHTS New York, NY , NY FOR A CURE HERMAN, CHARITY FAIR Delilah Ellenberg BEN'S MEMORIAL MILE County of Santa Clara Little Neck, NY Paul Silver Warrant Downers Grove, IL San Jose, CA

80 ANNUAL REPORT 2017 2017 FINANCIAL SUMMARY

We are pleased to report on the financial position and results of the Brain & Behavior Research Foundation for 2017. With great thanks and appreciation, we acknowledge the outstanding commitment of Foundation leadership, dedicated staff, volunteers and our donors that allow the Foundation to perform its vital work. We are grateful to the Foundation Scientific Council, our distinguished research leaders covering virtually every major discipline within brain and behavior science, who volunteer their expertise to select and recommend the most promising projects to fund.

In 2017, contributions remained strong and bequests continued to provide major support for which we are truly thankful to all of our supporters for their generosity. We would like to again acknowledge the extraordinary bequest from the late Oliver D. Colvin, Jr. that continues to impact the work of the Foundation. Together, all these donations further the Foundation’s mission to alleviate the suffering caused by mental illness by awarding grants that will lead to advances and breakthroughs in scientific research.

With another strong year of results, we continue to move forward with our aim of accelerating research accomplishments to help those living with mental illness to live full and productive lives. During 2017, the Foundation awarded additional NARSAD Grants to bring the total investment in mental health research to more than $380 million since inception.

We remain very appreciative and thankful for the generosity of the two family foundations who have underwritten, once again, the Foundation's fundraising and administration expenses. This allows for contributions targeted for research to go directly to funding NARSAD Grants. The financial report shown herein has been summarized from our 2017 audited financial statements. The Foundation’s complete audited financial statements and our most recent IRS Form 990 are available online at bbrfoundation.org or contact our office at 800.829.8289 for copies of the material.

www.bbrfoundation.org 81 Combined Statement of Financial Position

DECEMBER 31, 2017

ASSETS Cash and cash equivalents $4,634,731 Investments, at fair value 21,240,187 Contributions receivable 855,135 Pledges receivable, net 2,480,769 Prepaid expenses and other assets 40,433 Assets held in charitable remainder trusts 1,466,530 Fixed assets, net 13,933 Security deposits 77,110 $30,808,828

LIABILITIES AND NET ASSETS Liabilities Accounts payable and accrued expenses $102,346 Grants payable 20,280,242 Accrued compensation 80,869 Annuities payable 802,586 Charitable gift annuities payable 263,234 Total Liabilities 21,529,277 Net Assets Unrestricted 4,366,051 Permanently restricted 4,913,500 Total Net Assets 9,279,551 $30,808,828

82 ANNUAL REPORT 2017 Combined Statement of Activities

YEAR ENDED DECEMBER 31, 2017 SUPPORT AND REVENUE

Contributions $13,748,895

Special events, net 372,252 Contribution of services 1,918,998 Bequests 2,617,803 Net realized and unrealized gains on investments 2,807,211 Net appreciation of assets held in charitable remainder trusts 155,988 Dividend and interest income 540,212 Total Support and Revenue 22,161,359

EXPENSES Program Services Research grants and awards 16,340,921 Scientific advancement 2,294,603 Program support 2,877,594 Total Program Services 21,513,118 Supporting Services Fundraising* 924,171 Administration* 1,700,884

Total Supporting Services 2,625,055 Total Expenses 24,138,173 Change in Net Assets (1,976,814)

Net Assets, beginning of year 11,256,365

Net Assets, end of year $9,279,551

*All fundraising and administration expenses are funded by specially designated grants.

www.bbrfoundation.org 83 747 Third Avenue, 33rd Floor, New York, NY 10017 646.681.4888 | 800.829.8289 [email protected] bbrfoundation.org

Investing in Breakthroughs to Find a Cure 100% of every dollar donated for research is invested in our research grants. Our operating expenses are covered by separate foundation grants.

Our Mission: The Brain & Behavior Research Foundation is committed to alleviating the suffering caused by mental illness by awarding grants that will lead to advances and breakthroughs in scientific research. BBRF’ s four-star rating from Charity Navigator, the most well-respected nonprofit rating organization, provides How We Do It: our donors with confidence that their funds are being The Foundation funds the most innovative ideas in used appropriately. BBRF’ s four-star rating means that neuroscience and psychiatry to better understand the we adhere to best practices including accountability causes and develop new ways to treat brain and behavior and transparency. Our stellar track record for donor disorders. These disorders include addiction, ADHD, stewardship ensures that every dollar donated for anxiety, autism, bipolar disorder, borderline personality research goes directly to research. disorder, depression, eating disorders, OCD, PTSD, schizophrenia, and suicide prevention.

Our Credentials: Since 1987, we have awarded more than $380 million to fund more than 5,500 grants to more than 4,500 scientists around the world.

Our Vision: To dramatically improve the lives of those with mental illness and ultimately enable people to live full, happy, and productive lives.

© 2018 The Brain & Behavior Research Foundation