Disclosure/Conflict of Interest Statement As a provider accredited by the Accreditation Council for Continuing Medical Education (ACCME) and the American Nurses Credentialing Center (ANCC), the American College of Cardiology Foundation (ACCF) must ensure balance, independence, objectivity and scientific rigor in all of their directly provided or jointly provided/co-provided educational activities. Planners, presenters, and other contributors, in a position to control the content are required to disclose to the audience all relevant financial relationships he/she and/or his/her spouse or domestic partner may have, occurring within the past 12 months, with any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on, patients. When an unlabeled use of a commercial product or an investigational use not yet approved for any purpose is discussed during an educational activity, the contributor should disclose that the product is not labeled for the use under discussion or that the product is still investigational.

ACCF is committed to providing its learners with high-quality activities and materials that promote improvements and quality in health care and not a specific proprietary business or commercial interest. The intent of this disclosure is not to prevent participation in educational activities by persons with a financial or other relationship, but rather to provide learners with information on which they can make their own determination whether financial interests or relationships may influence the educational activity.

ACCF assesses conflicts of interest (COI) with its faculty, planners, managers, staff and other individuals who are in a position to control the content of CME/CNE activities. All relevant potential conflicts of interest that are identified are thoroughly vetted through a process that includes course directors and appropriate peer review by education committee chairs/members, for fair balance, scientific objectivity and validity, and patient care and safety recommendations.

Please note ACCF staff involved with this activity have nothing to disclose.

Course Director Washington, DC Valentin Fuster, MD, PhD, MACC Director, Mount Sinai Heart Disclosures Physician-in-Chief, Mount Sinai Hospital Nothing to disclose Director, Zena and Michael A. Wiener Cardiovascular Institute and Faculty Marie-Josée and Henry R. Kravis Center for Anelechi Anyanwu, MD Cardiovascular Health Professor, Cardiovascular Surgery Richard Gorlin, MD Heart Research Foundation Mount Sinai Health System and Icahn School of Professor of Cardiology Medicine Mount Sinai Health System and Icahn School of New York Medicine New York Disclosures General Director, Centro Nacional de Nothing to disclose Investigaciones Cardiovasculares Carlos III (CNIC) Eloisa Arbustini, MD, PhD Madrid Director, Center for Inherited Cardiovascular Diseases Disclosures IRCCS Foundation Policlinico San Matteo Nothing to disclose Pavia, Italy

Nurse Planner Disclosures Chris Keenan, RN, MSN, CCRN Nothing to disclose Associate Director, Education Content Manager American College of Cardiology Joseph E. Bavaria, MD, FACC Robert O. Bonow, MD, MACC Professor of Surgery Goldberg Distinguished Professor of Cardiology Hospital of the University of Pennsylvania Director, Center for Cardiovascular Innovation Philadelphia Northwestern University Feinberg School of Medicine Disclosures Chicago Consultant Fees/Honoraria St. Jude Medical Disclosures Data Safety Monitoring Board Research Grants Harvard Clinical Research Institute Boston Scientific; Edwards Lifesciences; WL Gore & Associates Other Relationships Gilead (Reviewer of Grant Applications); Journal of Deepak L. Bhatt, MD, MPH, FACC the American Medical Association (Editor) Executive Director of Interventional Cardiovascular Programs Eugene Braunwald, MD, MACC Brigham and Women’s Hospital Heart and Distinguished Hersey Professor of Medicine Vascular Center Harvard Medical School Professor of Medicine Founding Chairman, TIMI Study Group Harvard Medical School Brigham and Women’s Hospital Boston Boston

Disclosures Disclosures Consultant Fees/Honoraria Consultant Fees/Honoraria Elsevier Practice Update Cardiology Bayer HealthCare; Daiichi Sankyo, Inc.; Medscape; Menarini International; Merck & Co., Other Relationships Inc.; Novartis; Sanofi; The Medicines Company Belvoir Publications (Editor in Chief, Harvard Heart Letter); Cardax (Advisory Board);Clinical Cardiology Research Grants (Associate Editor); Elsevier (Royalty); Journal of AstraZeneca; Bristol-Myers Squibb; Daiichi Invasive Cardiology (Editor in Chief); Medscape Sankyo, Inc.; Duke University; GlaxoSmithKline; Cardiology (Advisory Board); Merck & Co., Inc. Johnson and Johnson; Merck & Co., Inc.; Sanofi (Planning Committee); Regado Biosciences (Advisory Board); Slack Publications/Cardiology Research Blase A. Carabello, MD, FACC Foundation (Editor); WebMD (Steering Committee) Chair, Cardiology Medical Director, Heart Valve Center Research Grants Mount Sinai Health System and Icahn School of Amarin; AstraZeneca; Bristol-Myers Squibb; Eisai; Medicine Ethicon; FlowCo; Forest; Ischemix; Medtronic; New York Pfizer Inc; PLx Pharma; Roche; Sanofi; Takeda; The Medicines Company Disclosures Data Safety Monitoring Board William E. Boden, BS, MD, FACC Edwards Lifesciences Chief of Medicine Samule S. Stratton VA Medical Center Other Relationships Albany, NY Medtronic (Member CoreValve Steering Committee)

Disclosures Mark A. Creager, MD, FACC Consultant Fees/Honoraria Director, Heart and Vascular Center Abbott; Arbor Pharmaceuticals; CardioDx; Senior Physician Janssen Pharmaceuticals, Inc. Brigham and Women’s Hospital Professor of Medicine, Cardiology Harvard Medical School Research Grants Boston Abbott; Boston Scientific; Edwards Lifesciences; WL Gore & Associates Disclosures Nothing to disclose Christopher B. Granger, MD, FACC Professor of Medicine Raffaele De Caterina, MD, PhD Division of Cardiology, Department of Medicine Chair of Cardiology Director, Cardiac Care Unit G. d’Annunzio University of Chieti Duke University Medical Center Chieti, Italy Durham, NC

Disclosures Disclosures Consultant Fees/Honoraria Consultant Fees/Honoraria Bayer HealthCare; Boehringer Ingelheim; Bristol- AstraZeneca; Bayer HealthCare; Boehringer Myers Squibb; Daiichi Sankyo, Inc.; Eli Lilly; Ingelheim; Bristol-Myers Squibb; Daiichi Sankyo, Novartis Inc.; Eli Lilly; Gilead; GlaxoSmithKline; Janssen Pharmaceuticals, Inc.; Medtronic; Pfizer Inc; Research Grants Roche; Ross Medical Corporation; Salix Roche Pharmaceuticals, Ltd.; Sanofi; Takeda; The Medicines Company Kenneth A. Ellenbogen, MD, FACC Chairman, Division of Cardiology Research Grants Virginia Commonwealth University (VCU) School Ametheon; AstraZeneca; Bayer HealthCare; of Medicine Boehringer Ingelheim; Bristol-Myers Squibb; Richmond, VA Daiichi Sankyo, Inc.; Eli Lilly; Gilead; GlaxoSmithKline; Janssen Pharmaceuticals, Inc.; Disclosures Medtronic; Merck & Co. Inc.; Pfizer Inc; Roche; Consultant Fees/Honoraria Sanofi; Takeda; The Medicines Company Atricure; Biosense-Webster; Biotronik, Inc.; Boston Scientific; Daiichi Sankyo, Inc.; Janssen Roger J. Hajjar, MD, FACC Pharmaceuticals, Inc.; Medtronic; Pfizer Inc; Director, Cardiovascular Research Center Sentreheart; St. Jude Medical Arthur and Janet C. Ross Professor of Medicine Professor of Gene and Cell Medicine Research Grants Mount Sinai Health System and Icahn School of Biosense-Webster; Boston Scientific; Medtronic; Medicine NIH; Sanofi New York

Ted Feldman, MD, FACC Disclosures Director Ownership Interest/Partnership/ Principal Cardiac Catheterization Laboratories Celladon; Nanocor Evanston Hospital NorthShore University Health System Henry R. Halperin, MA, MD Evanston, IL Professor of Biomedical Engineering and Radiology Disclosures Professor of Medicine Consultant Fees/Honoraria Johns Hopkins Medicine Abbott; Boston Scientific; Coherex; Daiichi Baltimore Sankyo, Inc./Eli Lilly and Company; Edwards Lifesciences; Intervalve; WL Gore & Associates Disclosures Consultant Fees/Honoraria Taser International; ZOLL Medical Corporation

Other Relationships Professor Emeritus of Medicine Imricor (Potential Royalty) University of Cincinnati College of Medicine Cincinnati Ownership Interest/Partnership /Principal MRI Interventions Disclosures Consultant Fees/Honoraria Research Grants Resmed; Respicardia; Respironics ZOLL Medical Corporation Speaker’s Bureau Jonathan L. Halperin, MD, FACC Respironics Robert and Harriet Heilbrunn Professor of Medicine Jason C. Kovacic, MBBS, PhD, FACC Director, Clinical Cardiology Services Associate Professor Medicine, Cardiology Zena and Michael A. Wiener Cardiovascular Mount Sinai Health System and Icahn School of Institute Medicine Mount Sinai Health System and Icahn School of New York Medicine New York Disclosures Research Grants Disclosures AstraZeneca Consultant Fees/Honoraria Boehringer Ingelheim; Boston Scientific; Johnson William E. Lawson, MD, FACC and Johnson; Medtronic; Pfizer Inc Governor American College of Cardiology, Downstate New Christian W. Hamm, MD, PhD, FACC York Professor of Internal Medicine and Cardiology President, The New York Cardiological Society, University of Giessen, Germany Inc. Medical Director Professor, Department of Internal Medicine Kerckhoff Heart and Thorax Center Co-director, Heart Institute Bad Nauheim, Germany Director, Heart Center Outcomes Research Director, Preventive Cardiology Disclosures Director, Interventional Cardiology Fellowship Consultant Fees/Honoraria Program Abbott; AstraZeneca; Boehringer Ingelheim; Director, Invasive Cardiology BRAHMS; Daiichi Sankyo, Inc.; Stony Brook University Medical Center GlaxoSmithKline; Medtronic; SHS Stony Brook University Hospital Stony Brook, NY Speaker’s Bureau Bayer HealthCare; Eli Lilly; Sanofi Disclosures Nothing to disclose Shalom Jacobovitz Chief Executive Officer Donna M. Mancini, MD American College of Cardiology Medical Director Washington, DC Center for Advanced Cardiac Care The New York Presbyterian Hospital Disclosures Choudhrie Professor of Medicine Officer, Director, Trustee or Other Fiduciary Role Columbia University Clene Nano Medicine New York

Shahrokh Javaheri, MD Disclosures Sleep Physician Speaker’s Bureau Bethesda North Hospital AmgeBarry J. Maron, MD, FACC Director, Hypertrophic Cardiomyopathy Center Massachusetts General Hospital Center for Minneapolis Heart Institute Foundation Systems Biology Minneapolis Associate Professor Harvard Medical School Disclosures Boston Consultant Fees/Honoraria Gene Dx; Medtronic Disclosures Nothing to disclose Manuel Mayr, MD, PhD Professor of Cardiovascular Proteomics Jagat Narula, MD, PhD, MACC The James Black Centre Chief of Cardiology King’s College, University of London Mount Sinai St. Luke’s and Mount Sinai Roosevelt London Associate Dean of Global Affairs Professor of Medicine, Cardiology Disclosures Professor of Radiology Nothing to disclose Mount Sinai Health System and Icahn School of Medicine Darren K. McGuire, MD, MHSC, FACC New York Professor of Medicine University of Texas Southwestern Medical Center Disclosures Dallas Heart Ball Chair for Heart Disease Research Grants Research in Women GE Healthcare; Philips Medical Systems Dallas Christopher M. O’Connor, MD, FACC Disclosures Chief Executive Officer Consultant Fees/Honoraria Inova Heart and Vascular Institute Boehringer Ingelheim; Lexicon; Merck & Co., Inova Fairfax Hospital Inc.; Novo Nordisk; Regeneron; Sanofi Falls Church, VA

Data Safety Monitoring Board Disclosures GlaxoSmithKline; Janssen Pharmaceuticals, Inc.; Consultant Fees/Honoraria Orexigen Therapeuitcs; Takeda AbbVie, Inc.; Actelion; Bayer HealthCare; Bristol- Myers Squibb; Cardiorentis; ResMed; Roche Research Grants AstraZeneca; Boehringer Ingelheim; Eli Lilly; Ownership Interest/Partnership/Principal Merck & Co., Inc.; Novo Nordisk; Takeda Biscardia, LLC

Vallerie V. McLaughlin, MD, FACC Research Grants Professor, Internal Medicine Roche University of Michigan Ann Arbor, MI Jeffrey W. Olin, DO, FACC Director, Vascular Medicine and Vascular Disclosures Diagnostic Laboratory Consultant Fees/Honoraria Professor of Medicine Actelion; Bayer HealthCare; Caremark; Gilead; Mount Sinai Health System and Icahn School of United Therapeutics Medicine New York Research Grants Actelion; Bayer HealthCare; Gilead Disclosures Consultant Fees/Honoraria Matthias Nahrendorf, MD, PhD Merck & Co. Inc.; Novartis; Plurestem Director, Mouse Imaging Program Other Relationships Research Grants AstraZeneca (International Steering Committee) Abbott; Edward Lifesciences

Ownership Interest/Partnership/Principal Clive Rosendorff, MD, PhD, DScMed, FACC Northwind Pharmaceuticals Professor of Medicine, Cardiology Mount Sinai Health System and Icahn School of Research Grants Medicine AstraZeneca New York

Sean Patrick Pinney, MD, FACC Disclosures Director of Heart Failure and Transplantation Nothing to disclose Associate Professor of Medicine, Cardiology Mount Sinai Health System and Icahn School of Marc Steven Sabatine, MD, MPH, FACC Medicine Lewis Dexter, MD Distinguished Chair in New York Cardiovascular Medicine Brigham and Women’s Hospital Disclosures Professor Consultant Fees/Honoraria Harvard Medical School Acorda Therapeutics, Inc.; Thoratec Corporation; Boston XDx Disclosures Research Grants Consultant Fees/Honoraria Thoratec Corporation Amgen; AstraZeneca; Caremark; Intarcia Therapeutics, Inc.; Merck & Co., Inc. Vivek Y. Reddy, MD Director, Cardiac Electrophysiology Research Grants Helmsley Trust Professor of Medicine Abbott; Amgen; AstraZeneca; Critical Mount Sinai Health System and Icahn School of Diagnostics; Daiichi Sankyo, Inc.; Eisai; Gilead; Medicine GlaxoSmithKline; Intarcia Therapeutics, Inc.; New York Merck & Co., Inc.; Roche; Sanofi; Takeda

Disclosures Samin K. Sharma, MBBS, FACC Consultant Fees/Honoraria Dean of International Clinical Affiliations Abiomed; Biosense-Webster; Boston Scientific; Professor of Medicine, Cardiology CardioFocus; CardioInsight; Coherex; EBR; Mount Sinai Health System and Icahn School of Impulse Dynamics; Medtronic; Philips Medical Medicine Systems; Sentreheart; St. Jude Medical New York

Ownership Interest/Partnership/Principal Disclosures ACT; Acutus Medical; Cibiem; Circa; DC Devices; Speaker’s Bureau Guided Delivery Systems; Javelin; Keystone; Abbott Vascular; Abiomed; Boston Scientific; CSI Magnetecs; Middlepeak; Perseus; VytronUS (Cardiovascular Systems, Inc.); TriReme Medical

Charanjit S. Rihal, MD, MBA, FACC Christopher J. White, MD, FACC Chair, Division of Cardiovascular Diseases Professor and Chairman of Medicine Mayo Clinic Ochsner Clinic School Rochester, MN Ochsner Medical Center New Orleans Disclosures Consultant Fees/Honoraria Disclosures Abbott Vascular Consultant Fees/Honoraria Neovasc Nothing to disclose Research Grants Neovasc; Surmodics

David J. Wilber, MD, FACC Director, Division of Cardiology and Cardiovascular Institute Stritch School of Medicine Loyola University Medical Center Maywood, IL

Disclosures Consultant Fees/Honoraria Biosense-Webster; Biotronik, Inc.; Medtronic; St. Jude Medical

Kim A. Williams, MD, FACC Chief of Cardiology Rush University Medical Center President, American College of Cardiology Chicago

Disclosures Nothing to disclose

Joseph C. Wu, MD, PhD, FACC Director, Stanford Cardiovascular Institute Professor Department of Medicine (Cardiology) Department of Radiology (Molecular Imaging Program) Stanford University School of Medicine Stanford, CA

Disclosures Consultant Fees/Honoraria Caladrius

Ownership Interest/Partnership/Principal Stem Cell Theranostics

Edward T. H. Yeh, MD, FACC Professor and Chairman Ting Tsung and Wei Fong Chao Distinguished Chair Department of Cardiology Division of Internal Medicine The University of Texas MD Anderson Cancer Center Houston

Disclosures