Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis
Article Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis Highlights Authors d Expression of mitochondrial complexes increases at the Ruth Beckervordersandforth, transition from NSC to IPC Birgit Ebert, Iris Schaffner,€ ..., Sebastian Jessberger, Hongjun Song, d Genetic inhibition of mitochondrial function inhibits D. Chichung Lie neurogenesis at IPC stage Correspondence d Mitochondrial dysfunction and aging produce similar neurogenesis phenotypes ruth.beckervordersandforth@fau.de (R.B.), chi.lie@fau.de (D.C.L.) d Enhancing mitochondrial function ameliorates age-related neurogenesis deficits In Brief Beckervordersandforth, Ebert et al. demonstrate that mitochondrial complex function functionally demarcates an early developmental step in adult hippocampal neurogenesis and identify mitochondrial dysfunction as a candidate target to counter age-associated neurogenesis deficits. Beckervordersandforth et al., 2017, Neuron 93, 560–573 February 8, 2017 ª 2016 Elsevier Inc. http://dx.doi.org/10.1016/j.neuron.2016.12.017 Neuron Article Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis Ruth Beckervordersandforth,1,10,* Birgit Ebert,1,2,10 Iris Schaffner,€ 1 Jonathan Moss,3 Christian Fiebig,1 Jaehoon Shin,4 Darcie L. Moore,5 Laboni Ghosh,5 Mariela F. Trinchero,6 Carola Stockburger,7 Kristina Friedland,7 Kathrin Steib,2 Julia von Wittgenstein,1 Silke Keiner,8 Christoph Redecker,8 Sabine
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