JMIR SERIOUS GAMES Schättin et al Original Paper Design and Evaluation of User-Centered Exergames for Patients With Multiple Sclerosis: Multilevel Usability and Feasibility Studies Alexandra Schättin1, PhD; Stephan Häfliger1, MSc; Alain Meyer1, MSc; Barbara Früh1, MSc; Sonja Böckler2, MA; Yannic Hungerbühler2, BA; Eling D de Bruin1,3, PhD; Sebastian Frese4, PhD; Regula Steinlin Egli5, BSc; Ulrich Götz2, Dipl; René Bauer2, Lic Phil; Anna Lisa Martin-Niedecken2, PhD 1Department of Health Sciences and Technology, Institute of Human Movement Sciences and Sport, ETH Zurich, Zurich, Switzerland 2Department of Design, Subject Area in Game Design, Zurich University of the Arts, Zurich, Switzerland 3Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden 4Technology and Innovation Unit and Department of Research, ZURZACH Care, Bad Zurzach, Switzerland 5Physiotherapy Langmatten, Binningen, Switzerland Corresponding Author: Alexandra Schättin, PhD Department of Health Sciences and Technology, Institute of Human Movement Sciences and Sport ETH Zurich IBWS, HCP H, Leopold Ruzicka Weg 4 Zurich, 8093 Switzerland Phone: 41 44 633 90 57 Email:
[email protected] Related Article: This is a corrected version. See correction statement in: https://games.jmir.org/2021/2/e30326/ Abstract Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Patients with MS experience a wide range of physical and cognitive dysfunctions that affect their quality of life. A promising training approach that concurrently trains physical and cognitive functions is video game±based physical exercising (ie, exergaming). Previous studies have indicated that exergames have positive effects on balance and cognitive functions in patients with MS.