United States Patent (19) (11) 4,378,354 Ghyczy Et Al
United States Patent (19) (11) 4,378,354 Ghyczy et al. 45 Mar. 29, 1983 54) NFLAMMATON-PREVENTING 51 Int. Clº. A61K 31/685 PHARMACEUTICAL COMPOSITION OF (52] U.S. Cl. .… 424/199 ORAL ADMINISTRATION 58) Field of Search......................................... 424/199 75) Inventors: Miklos Ghyczy; Adorjan Erdös, both of Cologne; Ginter Heidemann, Primary Examiner-Stanley J. Friedman Geilenkirchen-Tripsrath; Götz Attorney, Agent, or Firm-Burns, Doane, Swecker & Ritzmann, Cologne, all of Fed. Rep. Mathis of Germany 57 ABSTRACT 73) Assignee: A. Nattermann & Cie. GmbH, Cologne, Fed. Rep. of Germany A novel pharmaceutical composition is provided which is suitable for the prevention of inflammation and which (21) Appl. No.: 266,217 comprises non-steroidal inflammation-preventing com 22) Filed: May 22, 1981 pound (e.g. pyrazolones, salicylic acid derivatives, in doles, indanes, and phenylacetic acid and anthranilic Related U.S. Application Data acid derivatives) and at least one phospholipid. 62) Division of Ser. No. 104,449, Dec. 14, 1979, Pat. No. 4,332,795. 17 Claims, No Drawings 4,378,354 2 tic substances can be prevented if these substances are INFLAMMATION-PREVENTING combined in a suitable manner with phospholipids. The PHARMACEUTICAL COMPOSITION OF ORAL medicinal compositions of the present invention will ADMINISTRATION therefore contain these antiphologistic substances in conjunction with phospholipids. The phospholipids This is a division of application Ser. NO. 104,449 filed have the advantage over the previously described sub Dec. 17, 1979 now U.S. Pat. No. 4,332,795. stances in that they are body-inherent, can be readily broken down within the body, do not promote any side BACKGROUND OF THE PRESENT INVENTION effects (even if administered continuously (see J.
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