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Biochemistrystanford00kornrich.Pdf
University of California Berkeley Regional Oral History Office University of California The Bancroft Library Berkeley, California Program in the History of the Biosciences and Biotechnology Arthur Kornberg, M.D. BIOCHEMISTRY AT STANFORD, BIOTECHNOLOGY AT DNAX With an Introduction by Joshua Lederberg Interviews Conducted by Sally Smith Hughes, Ph.D. in 1997 Copyright 1998 by The Regents of the University of California Since 1954 the Regional Oral History Office has been interviewing leading participants in or well-placed witnesses to major events in the development of Northern California, the West, and the Nation. Oral history is a method of collecting historical information through tape-recorded interviews between a narrator with firsthand knowledge of historically significant events and a well- informed interviewer, with the goal of preserving substantive additions to the historical record. The tape recording is transcribed, lightly edited for continuity and clarity, and reviewed by the interviewee. The corrected manuscript is indexed, bound with photographs and illustrative materials, and placed in The Bancroft Library at the University of California, Berkeley, and in other research collections for scholarly use. Because it is primary material, oral history is not intended to present the final, verified, or complete narrative of events. It is a spoken account, offered by the interviewee in response to questioning, and as such it is reflective, partisan, deeply involved, and irreplaceable. ************************************ All uses of this manuscript are covered by a legal agreement between The Regents of the University of California and Arthur Kornberg, M.D., dated June 18, 1997. The manuscript is thereby made available for research purposes. All literary rights in the manuscript, including the right to publish, are reserved to The Bancroft Library of the University of California, Berkeley. -
Woody Powell
Note to readers: Please do not be alarmed by the length. There is a 48 page Appendix. You may want to print only the paper itself, pp. 1- 66. We would, however, welcome reactions to the Appendix and thoughts on how and whether to present the case materials. Chance, Necessité, et Naïveté: Ingredients to create a new organizational form* Walter W. Powell Kurt Sandholtz Stanford University January, 2010 *The title comes from remarks by Genentech co-founder Herbert Boyer (2001: 95-96): “I think if we had known about all the problems we were going to encounter, we would have thought twice about starting. I once gave a little talk to a group at a Stanford Business School luncheon, and I took off on the title of a book on evolution by Jacques Monod…Chance et Necessité. The title of my talk was ‘Chance, Necessité, et Naïveté.’ Naïveté was the extra added ingredient in biotechnology.” We thank Tricia Soto, librarian at the Center for Advanced Study in the Behavioral Sciences, and Tanya Chamberlain for assistance in finding archival materials. Martin Kenney was most generous in providing us with the source documents he used in writing his 1986 book, one of the very first studies of the development of the biotechnology industry. Our thanks to the Center for Advanced Study for hosting Professor Powell while the chapter was prepared. We are grateful to Pablo Boczkowski, Ron Burt, John Padgett, members of the Networks and Organizations Workshop at Stanford, and the Organizations and Markets workshop at the University of Chicago for comments on our initial draft. -
Top 100 Living Contributors to Biotechnology
Over the last 30 years, a small group of visionaries in science, technology, legislation and business have driven the development of biotechnology. THE Today, in the midst of tremendous advances in medicine and agriculture, this exhibition and accompanying brochure pays tribute to the leaders that have shaped the biotechnology industry. TOP The Top 100 Living Contributors to Biotechnology have been selected by their peers and through independent polls conducted by Reed Exhibitions, a division of Reed Elsevier. Senior staff throughout the biotechnology industry have identified the most influential and inspirational pioneers. The results 100 are presented here alphabetically. LIVING CONTRIBUTORS To those named in the Top 100, and the many other contributors not listed, TO BIOTECHNOLOGY the biotechnology community is deeply appreciative. P 1 4 MICHAEL ASHBURNER SEYMOUR BENZER PAUL BERG Michael Ashburner is Professor Seymour Benzer instilled the Paul Berg is Cahill Professor in of Biology at the University of fundamental idea that genes Cancer Research, Emeritus, at Cambridge where he received his control behaviour. He began his the Stanford University School undergraduate degree and PhD, career studying gene structure of Medicine, and director emeri- both in genetics. Ashburner’s and code, developing a method tus of the Beckman Centre for current major research interests to determine the detailed struc- Molecular and Genetic are the structure and evolution of ture of viral genes in 1955. He Medicine. He is one of the prin- genomes. Most of his research then switched to the field of cipal pioneers in the field of 33 has been with the model organ- neurogenetics, focusing on “gene splicing.” Berg, along with ism Drosophila melanogaster, the inheritance of behaviour. -
Alexza Pharmaceuticals 2006 Annual Report
vs. Alexza Pharmaceuticals 2006 Annual Report vs. fast delivery With many medical conditions, speed of treatment is critical. Episodes of these “acute and intermittent” conditions—such as migraine headaches, panic attacks, breakthrough pain, agitation, and more— can quickly become debilitating. Alexza’s Staccato® system provides needed medication as fast as an injection. With just one breath, patients receive a dose of pure aerosolized drug—deep into their lungs—where it is quickly absorbed into the blood stream to begin providing therapeutic effect. vs. easy to use Using a Staccato device is as simple and intuitive as breathing. Doses are pre-set and there are no controls to deal with. About the size of a cell phone, the device fits easily in a pocket or purse. Patients don’t need to learn how to use the Staccato device—it is intuitive—nor do they have to rely on a caregiver to administer their medication. When the need arises, even unexpectedly, one breath is all it takes. 2 vs. more consistent Other inhalation drug delivery methods add fillers and excipients to the therapeutic compound. The proprietary Staccato system uses pure drug layered as a thin film on a substrate. The substrate heats rapidly when triggered by a patient inhalation. The drug instantly vaporizes and condenses into aerosol particles ranging from 1 to 5 microns in diameter—the optimal size to reach the highly vascular tissue of the deep lung for absorption into the blood stream. And the system produces a consistently high emitted dose regardless of the patient’s breathing pattern. 4 vs. -
Dear Arthur, Roger, Tom, Ken, Welcome to Tokyo! Kornberg Family Photo in 1959, Stockholm Roger Ken Sylvy Arthur Tom
Toward innovative research: Lessons from the Kornbergs July 23, 2007 Yasuda Auditorium Introduction by Ken-ichi Arai Kornberg Family Photo in 2006, Stockholm Dear Arthur, Roger, Tom, Ken, welcome to Tokyo! Kornberg Family Photo in 1959, Stockholm Roger Ken Sylvy Arthur Tom Sylvy discovered the enzyme that makes huge polyphosphate chains. Her high intelligence led to key insights at many stages of our work on replication. For the Love of Enzymes The Odyssey of a Biochemist Arthur published books; DNA Replication, For the Love of Enzymes, Golden Helix (Inside Biotech Ventures). This book is a modern-day “Book of Five Rings” that replaces the medium of Swordmanship with that of biochemistry, particularly enzymology. In relating his story, Kornberg never avoids the difficult question of why? Joining the Enzyme Hunters: Arthur’s Mentors Gerty & Carl Cori in 1947 Gerty had no faculty appointment until 1947 when she shared the Nobel Prize Severo Ochoa in 1955 with Carl. I had come to the Cori laboratory to solve the major problem in I went to New York to meet Ochoa. He biochemistry, the mechanism of aerobic agreed to take me and I started as his phosphorylation. first postdoctoral student a month later. Arthur Kornberg Network S. Ochoa NYU, USA A. Kornberg O. Hayaishi Stanford, USA Kyoto A. Kornberg, Y. Kaziro, O. Hayaishi, R.& T. Okazaki C. Weissmann K. Ueda, K. & N. Arai Y. Nishizuka, K. Ueda, T. Honjo H. Okayama, T. Shimizu P. Berg Stanford, USA C. Weissmann Y. Kaziro R.&T. Okazaki H. Okayama Zurich, Swiss IMSUT Nagoya R. Mulligan T. Tadatsugu, K.& N. -
Learning Outcomes
General Catalog 2014 - 2015 TABLE OF CONTENTS Academic Calendar ..................................... 3 Undergraduate Academic Information ................................................... 60 Introduction to NDNU ............................. 5 Undergraduate Degrees ............................ 60 President’s Welcome ................................. 5 Undergraduate Policies and Mission Statement ..................................... 6 Procedures ......................................... 78 Vision Statement ....................................... 6 History of NDNU .................................... 6 Graduate General Regulations ................ 95 Academic Freedom Statement ................ 7 Statement of Nondiscrimination ............ 7 College of Arts and Sciences .................... 107 Accreditation .............................................. 8 Art/Art and Graphic Design ................. 107 Nature of Catalog ...................................... 8 Art Therapy Psychology ......................... 111 Clinical Psychology ................................. 118 Office of the Provost ................................... 10 Computer and Information Academic Affairs ....................................... 10 Science ................................................ 127 Student Affairs ........................................... 10 English ...................................................... 132 University Services .................................... 10 English for International Organizations, Activities, and Events .... 15 Students -
Early Days of Syntex Life After Syntex Continued from Page 8 Continued from Page 9
23-2 CHF 2005 9/8/05 2:45 PM Page 8 George Rosenkranz (center) displays a test tube of yam-derived diosgenin, the substance needed to produce steroid hormones, and its raw source material, Mexican yams. Grouped around him from left to right are Alex Nussbaum, Mercedes Velasco, Gilbert Stork, Jan Pataki, Enrique Batres, Juan Berlin, Carl Djerassi, Rosa Yashin, Octavio Mancera, Jesùs Romo. CHF Collections. Courtesy of Roche. LifeLife afterafter SyntexSyntex By Alejandro Zaffaroni Early Years of age. My father was in the banking business, Alejandro Zaffaroni at My life started in Montevideo, Uruguay, many and our family enjoyed a good standard of living. CHF in 2004. Photo by years ago. Uruguay is a small country; today Early in my life, I lost both my parents. My Steven Begleiter. it has three million people. Back then life in mother passed away when I was 12 years of age, Uruguay was wonderful. It was a great place to and my father when I was 18. Now, when I look live—safe and peaceful—and the standard of back, I think that loss forced me to learn to be on living was high. For many years, Uruguay was my own. I was also lucky enough to have an uncle known as the Switzerland of South America. and an older sister who supported and encour- The social and political organizations were aged me to continue my education. very progressive: women were allowed to vote; After earning a B.Sc. at the University of it had the highest rates of literacy; it was the Montevideo in 1941, I began studying at the first social democracy on the continent; pri- school of medicine. -
1.01 Reflections of a Medicinal Chemist
1.01 Reflections of a Medicinal Chemist: Formative Years through Thirty-Seven Years Service in the Pharmaceutical Industry R F Hirschmann, University of Pennsylvania, Philadelphia, PA, USA J L Sturchio, Merck & Co., Inc., Whitehouse Station, NJ, USA & 2007 Elsevier Ltd. All Rights Reserved. 1.01.1 Introduction 2 1.01.2 The Training of a Medicinal Chemist 2 1.01.2.1 Graduate School 2 1.01.2.2 My 37 Years At Merck & Co., Inc. 3 1.01.2.2.1 The cortisol era 3 1.01.2.2.2 Transfer to exploratory research 8 1.01.3 The Merger Between Merck & Co., Inc. and Sharp & Dohme 11 1.01.3.1 Transfer to West Point, PA 12 1.01.3.1.1 Compounds possessing two symbiotic biological activities 13 1.01.3.1.2 Methyldopa progenitors 13 1.01.3.1.3 The somatostatin program 14 1.01.3.1.4 The protease inhibitor program 14 1.01.4 P. Roy Vagelos, MD, Successor to Dr L. H. Sarett 15 1.01.4.1 A New Assignment: Vice President of Basic Research 16 1.01.4.2 A Breakthrough at the Squibb Institute of Medical Research 16 1.01.4.3 Improved Second-Generation Converting Enzyme Inhibitors 17 1.01.4.4 The Concept of ‘The Champion’ in Drug Discovery: Benign Prostatic Hypertrophy and the Inhibition of 5a-Reductase 17 1.01.4.5 Hypercholesterolemia: A Challenge for the Pharmaceutical Industry 18 1.01.4.5.1 A breakthrough at Sankyo: the discovery of compactin 18 1.01.4.5.2 The discovery of the first approved b-hydroxy-b-methylglutaryl-CoA reductase inhibitor, lovastatin 19 1.01.4.5.3 The discovery of simvastatin 19 1.01.4.5.4 Lipitor 19 1.01.4.5.5 A new mechanism to lower plasma cholesterol