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HISTORY of LEAD POISONING in the WORLD Dr. Herbert L. Needleman Introduction the Center for Disease Control Classified the Cause
HISTORY OF LEAD POISONING IN THE WORLD Dr. Herbert L. Needleman Introduction The Center for Disease Control classified the causes of disease and death as follows: 50 % due to unhealthy life styles 25 % due to environment 25% due to innate biology and 25% due to inadequate health care. Lead poisoning is an environmental disease, but it is also a disease of life style. Lead is one of the best-studied toxic substances, and as a result we know more about the adverse health effects of lead than virtually any other chemical. The health problems caused by lead have been well documented over a wide range of exposures on every continent. The advancements in technology have made it possible to research lead exposure down to very low levels approaching the limits of detection. We clearly know how it gets into the body and the harm it causes once it is ingested, and most importantly, how to prevent it! Using advanced technology, we can trace the evolution of lead into our environment and discover the health damage resulting from its exposure. Early History Lead is a normal constituent of the earth’s crust, with trace amounts found naturally in soil, plants, and water. If left undisturbed, lead is practically immobile. However, once mined and transformed into man-made products, which are dispersed throughout the environment, lead becomes highly toxic. Solely as a result of man’s actions, lead has become the most widely scattered toxic metal in the world. Unfortunately for people, lead has a long environmental persistence and never looses its toxic potential, if ingested. -
Cyanide Poisoning and How to Treat It Using CYANOKIT (Hydroxocobalamin for Injection) 5G
Cyanide Poisoning and How to Treat It Using CYANOKIT (hydroxocobalamin for injection) 5g 1. CYANOKIT (single 5-g vial) [package insert]. Columbia, MD: Meridian Medical Technologies, Inc.; 2011. Please see Important Safety Information on slides 3-4 and full Prescribing Information for CYANOKIT starting on slide 33. CYANOKIT is a registered trademark of SERB Sarl, licensed by Meridian Medical Technologies, Inc., a Pfizer company. Copyright © 2015 Meridian Medical Technologies, Inc., a Pfizer company. All rights reserved. CYK783109-01 November/2015. Indication and Important Safety Information……………………………………………………………………………….………..…..3 . Identifying Cyanide Poisoning……………………………………………………………………………………………………………….…………….….5 . How CYANOKIT (hydroxocobalamin for injection) Works……………………………………………………………….12 . The Specifics of CYANOKIT…………………………………………………………………………………………………………………………….………17 . Administering CYANOKIT………………………………………………………………………………………………………………………………..……….21 . Storage and Disposal of CYANOKIT…................................................................................................................................26 . Grant Information for CYANOKIT……………………………………………………………………………………………………………………....30 . Full Prescribing Information………………………………………………………………………………………………….………………………………33 Please see Important Safety Information on slides 3-4 and full Prescribing Information for CYANOKIT starting on slide 33. CYANOKIT (hydroxocobalamin for injection) 5 g for intravenous infusion is indicated for the treatment of known or suspected cyanide poisoning. -
WHO Guidance on Management of Snakebites
GUIDELINES FOR THE MANAGEMENT OF SNAKEBITES 2nd Edition GUIDELINES FOR THE MANAGEMENT OF SNAKEBITES 2nd Edition 1. 2. 3. 4. ISBN 978-92-9022- © World Health Organization 2016 2nd Edition All rights reserved. Requests for publications, or for permission to reproduce or translate WHO publications, whether for sale or for noncommercial distribution, can be obtained from Publishing and Sales, World Health Organization, Regional Office for South-East Asia, Indraprastha Estate, Mahatma Gandhi Marg, New Delhi-110 002, India (fax: +91-11-23370197; e-mail: publications@ searo.who.int). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. -
Acute Poisoning: Understanding 90% of Cases in a Nutshell S L Greene, P I Dargan, a L Jones
204 REVIEW Postgrad Med J: first published as 10.1136/pgmj.2004.027813 on 5 April 2005. Downloaded from Acute poisoning: understanding 90% of cases in a nutshell S L Greene, P I Dargan, A L Jones ............................................................................................................................... Postgrad Med J 2005;81:204–216. doi: 10.1136/pgmj.2004.024794 The acutely poisoned patient remains a common problem Paracetamol remains the most common drug taken in overdose in the UK (50% of intentional facing doctors working in acute medicine in the United self poisoning presentations).19 Non-steroidal Kingdom and worldwide. This review examines the initial anti-inflammatory drugs (NSAIDs), benzodiaze- management of the acutely poisoned patient. Aspects of pines/zopiclone, aspirin, compound analgesics, drugs of misuse including opioids, tricyclic general management are reviewed including immediate antidepressants (TCAs), and selective serotonin interventions, investigations, gastrointestinal reuptake inhibitors (SSRIs) comprise most of the decontamination techniques, use of antidotes, methods to remaining 50% (box 1). Reductions in the price of drugs of misuse have led to increased cocaine, increase poison elimination, and psychological MDMA (ecstasy), and c-hydroxybutyrate (GHB) assessment. More common and serious poisonings caused toxicity related ED attendances.10 Clinicians by paracetamol, salicylates, opioids, tricyclic should also be aware that severe toxicity can result from exposure to non-licensed pharmaco- -
POISONING Words to Know From
LEAD POISONING Words to Know from A to Z Contents Page 1 Introduction Page 2 Learn about Lead Poisoning Page 4 Protect Your Child from Lead Page 5 Get Support Page 6 Key Words Page 9 Lead Poisoning: Words to Know from A to Z Introduction Lead Poisoning: Words to Know from A to Z is a dictionary that gives the meaning of words you often hear or read about lead. Some of the words in A to Z have everyday meanings you might already know. In this dictionary, we give the meaning of the word as it relates to lead poisoning. Many of the words in this dictionary are used by doctors, nurses, and lead inspectors when they talk about lead poisoning. In the Key Words section, you will find words that are often used together. For example, you will see medical words about lead poisoning that you might hear at a health center. The words with their meanings are listed from A to Z. We show you how to say each word and use it in a sentence. 1 Learn about Lead Poisoning Swallowing or breathing in lead causes lead poisoning. Lead harms children between the ages of 0 and 6 years old. If you are pregnant, lead may also harm your baby. Lead hurts the brain and other parts of the nervous system. Some of the health problems caused by lead poisoning may never go away. Lead in a child’s body can: j Slow down growth and development j Damage hearing and speech j Cause behavior problems j Make it hard to pay attention and learn Brain Spinal Cord Nerves Nervous System 2 How do children get lead poisoning? Most children get lead poisoning from living or staying in older homes that have lead paint. -
Recognition and Management of Pesticide Poisonings
HIGHLIGHTS CHAPTER 8 Derived from living systems Bacillus thuringiensis is the most important live agent Biologicals and Insecticides Generally of low-order of Biological Origin toxicity Poison control center advice can help avoid potentially harmful treatment This chapter concerns several widely used insecticidal products of natural origin, and also certain agents usually identified as biological control agents. This latter group includes many living control agents, though only the bacterial agent Bacillus thuringi- SIGNS & SYMPTOMS ensis will be discussed in detail, as it is one of the most widely used. Other agents, such as parasitic wasps and insects, are so host specific they pose little or no risk to man. Highly variable based on Many of the pesticides in this chapter, with the notable exception of nicotine, are specific agents relatively less toxic to mammals than to insects. Consequently, there may be no findings Several cause GI irritation of toxicity following ingestion of these compounds. While clinicians should always consider calling their regional poison control center (1-800-222-1222) for advice on Nicotine may have serious any poisoning, it may be of particular value in the case of some of these biological CNS effects pesticides, where no treatment is warranted and poison control center advice can help Nicotine and sabadilla may avoid potentially harmful treatments. have cardiovascular effects Agents are presented in alphabetical order. TREATMENT AVERMECTIN Specific to the agent Source and Products Skin, eye, GI Avermectin and related products are synthetically derived from the toxin of the soil decontamination may be bacterium Streptomyces avermitilis. They are used for control of mites, fire ants (ant indicated bait stations) and other insects. -
2. What Is Lead Poisoning? 3. What Are the Health Effects of Lead Exposure?
QUESTIONS AND ANSWERS: INTERNATIONAL LEAD POISONING PREVENTION AWARENESS CAMPAIGN WEEK OF ACTION 22-28 OCTOBER 2017 1. What is lead? Lead is a naturally occurring toxic metal found in the Earth’s crust. It has many uses, including in the manufacture of lead-acid batteries for motor vehicles and energy storage, in pigments and paints, solder, ammunition, ceramic glazes, jewellery, toys and also in some cosmetics and traditional medicines. It also continues to be used in gasoline in a small number of countries. The processing, use and disposal of lead can result in environmental contamination and human exposure. As lead is an element, once released into the environment it persists as a potential source of exposure. 2. What is lead poisoning? Lead poisoning refers to excessive human exposure to lead. The most common route of exposure is ingestion. Exposure may occur over a short space of time (acute poisoning) or over a prolonged period (chronic poisoning). No safe level of exposure to lead has so far been identified. As a consequence some health authorities define excessive exposure as having a blood lead concentration above the reference value for the population as a whole. This reference value is usually the geometric mean blood lead concentration found in the highest 2.5% or 5% of the population, i.e. the 97.5th or 95th percentile respectively. For example, in the USA the 97.5th percentile blood lead concentration in children under six years of age is 5 µg/dL (1). This same concentration is the 98th percentile value for children under seven years in France (2). -
Forensic Toxicology in Death Investigation
If you have issues viewing or accessing this file contact us at NCJRS.gov. CHAPTER 5 Forensic Toxicology in Death Investigation Eugene C. Dinovo, Ph.D., and Robert H. Cravey Forensic toxicology is a highly specialized States, warrant an official investigation by the area of forensic science which requires exper coroner or medical examiner to determine the tise in analytical chemistry, pharmacology, cause of death. The resolution of many legal biochemistry, and forensic investigation. The questions depends on the official pronounce practicing forensic toxicologist is concerned ment of the cause of death. The settlement of not only with the isolation and identification insurance claims often rests on the pro of drugs and other pOlsons from tissues, but nouncement of the death investigator. Accu also with the interpretation of his findings for racy in determining the cause of death depends the medical examiner, coroner, or other legal on the cooperation and free flow of informa authority. tion among all members of the medicolegal In our modern drug-oriented society the investigative team: the police homicide need for the services of a toxicologist is clear. investigator, the medical examiner's investi The benefits received from medication are so gator, the forensic pathologist, the forensic well publicized that society tends to minimize toxicologist, and the medical examiner. the dangers and pitfalls. The American people The homicide investigator is usually the spend over $9 billion a year on drugs. In first to view the scene and, if he is properly 1971, the public spent approximately $5% bil trained, it is he who maintains the scene lion on prescription drugs and about $3'12 bil undisturbed for the medical examiner whom lion for over-the-counter medications (Arena he calls. -
Toxicity Associated with Carbon Monoxide Louise W
Clin Lab Med 26 (2006) 99–125 Toxicity Associated with Carbon Monoxide Louise W. Kao, MDa,b,*, Kristine A. Nan˜ agas, MDa,b aDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA bMedical Toxicology of Indiana, Indiana Poison Center, Indianapolis, IN, USA Carbon monoxide (CO) has been called a ‘‘great mimicker.’’ The clinical presentations associated with CO toxicity may be diverse and nonspecific, including syncope, new-onset seizure, flu-like illness, headache, and chest pain. Unrecognized CO exposure may lead to significant morbidity and mortality. Even when the diagnosis is certain, appropriate therapy is widely debated. Epidemiology and sources CO is a colorless, odorless, nonirritating gas produced primarily by incomplete combustion of any carbonaceous fossil fuel. CO is the leading cause of poisoning mortality in the United States [1,2] and may be responsible for more than half of all fatal poisonings worldwide [3].An estimated 5000 to 6000 people die in the United States each year as a result of CO exposure [2]. From 1968 to 1998, the Centers for Disease Control reported that non–fire-related CO poisoning caused or contributed to 116,703 deaths, 70.6% of which were due to motor vehicle exhaust and 29% of which were unintentional [4]. Although most accidental deaths are due to house fires and automobile exhaust, consumer products such as indoor heaters and stoves contribute to approximately 180 to 200 annual deaths [5]. Unintentional deaths peak in the winter months, when heating systems are being used and windows are closed [2]. Portions of this article were previously published in Holstege CP, Rusyniak DE: Medical Toxicology. -
Solvents/Inhalants Information for Health Professionals
Solvents/Inhalants Information for Health Professionals Introduction Inhalants compromise a wide variety of vapours, gases, and aerosols that can be inhaled to induce psychoactive (mind-altering) effects. Unlike other drugs, inhalants are available as legal products with low costs and wide availability. Examples include commercial products such as nail polish remover, hair sprays, lighter fluid, cleaning fluids, vegetable frying pan lubricants, and spray paints. These chemicals can be sniffed or inhaled because they are gaseous at room temperature and pressure. “Inhalant” is a general term that includes all substances used in this way. Most inhalants are volatile solvents, which are liquids that easily vaporize at room temperature and can contain many different chemicals that may be psychoactive. The majority of these solvents are produced from petroleum and natural gas. They have an enormous number of industrial, commercial and household uses, and are found in automobile fuels, cleaning fluids, toiletries, adhesives and fillers, paints, paint thinners, felt-tip markers, and many other products. In addition to volatile solvents, aerosols (hair spray, paint spray) can be abused as inhalants. Other inhalants include the nitrites (amyl and butyl, “poppers”, “Rush”) and gases such as the anesthetics nitrous oxide (laughing gas) and ether. Inhalants can be breathed in through the nose or mouth in a variety of ways, including spraying aerosols directly into the nose or mouth, “sniffing” or "snorting” fumes from containers, inhaling from balloons filled with nitrous oxide, “huffing” from an inhalant-soaked rag stuffed in the mouth, or “bagging”- pouring the substance over a cloth or into a plastic bag and breathing in the vapours. -
Toxic Exposure / Poisoning / Overdose
TOXIC EXPOSURE / POISONING / OVERDOSE GENERAL CONSIDERATIONS A. Consider the possibility of accidental or self-poisoning under the following conditions: 1. History of observed or admitted accidental or intentional ingestion 2. Coma of unknown origin 3. History of suicide gesture or attempt 4. Intoxicated behavior (hyperactive, hypoactive, unstable gait, lethargic, slurred speech) 5. Patients with altered mental status, particularly with bizarre behavior B. Scene safety is your primary concern. Potential threats include: 1. Violent, agitated behaviors from the patient 2. Possibility of the EMT becoming contaminated by the substance C. If suspected HazMat or WMD exposure: 1. Initial PPE should be Level A. 2. EMS personnel will NOT approach the victim without donning appropriate PPE or the victim has received emergency decontamination. D. Emergency decontamination procedures should be initiated whenever a victim has been exposed to a solid or liquid agent or the agent is unknown. With known agents, follow PPE and decontamination recommendations based on research. Emergency decontamination procedures should include: 1. Removal of all clothing, including undergarments 2. Body flushed with large quantities of water 3. Evacuation to an isolated area away from the agent release E. With known or suspected chemical / WMD exposure, contact Medical Control early and advise of the situation. F. EMS should consider the confirmed or potential release of a nerve agent when responding to an unspecified incident or scene involving: 1. An unknown illness involving a potentially large number of patients 2. An explosion from an unknown source at an event where a large number of people are in attendance 3. An incident where the initial EMS responders on scene suddenly become symptomatic 4. -
Lead Poisoning in Cattle
Agdex 663-40 Lead Poisoning In Cattle ead is the most common cause of cattle poisoning in The sources of lead LAlberta. Hundreds of animals in the province die each year or perform poorly after accidentally ingesting lead. More than 85 per cent of lead poisoning incidents among Gradual poisoning may also occur in areas with heavy cattle in Alberta result from accidental consumption of industrial pollution. discarded materials from farm vehicles or machinery. Used crankcase oil, discarded batteries, grease (which contains Lead poisoning can affect any cattle operation. Lead was up to 50 per cent lead), leaded gasoline and used engine likely responsible for the death of thousands of cattle and oil filters are the most dangerous materials. Drinking water illness among tens of thousands of cattle over the past that is contaminated from lead pipes or soldered tanks can 20 years. be a cause of poisoning, particularly in areas where the water is soft. Some trends have emerged from the incidents of lead poisoning in Alberta. Poisonings usually involve animals Junk piles in pastures are another from well-managed farms and ranches. common source of poisonous materials. Sometimes only one calf is affected. At Other sources include some crop sprays, other times more than 20 cows have been Lead poisoning putty, lead-based paints and painted lost in a single poisoning incident. surfaces, roofing materials, plumbing can affect any supplies, asphalt, lead shot, linoleum and oil field wastes. Boiled linseed oil, which Why lead affects cattle cattle operation contains lead, may poison livestock when it is used as a laxative.