Ardthe EULAR Journal Editor Josef S Smolen (Austria) and Disorders of Connective Tissue

Total Page:16

File Type:pdf, Size:1020Kb

Ardthe EULAR Journal Editor Josef S Smolen (Austria) and Disorders of Connective Tissue Annals of the Rheumatic Diseases publishes original work on all aspects of rheumatology ARDThe EULAR Journal Editor Josef S Smolen (Austria) and disorders of connective tissue. Laboratory Associate Editors Tristan Barber (UK) and clinical studies are equally welcome Francis Berenbaum (France) Dimitrios Boumpas (Greece) Editorial Board Gerd Burmester (Germany) Daniel Aletaha (Austria) Robert Landewé (The Netherlands) Mary Crow (USA) Johan Askling (Sweden) Rik Lories (Belgium) Contact Details Iain McInnes (UK) Sang-Cheol Bae (Korea) Ingrid Lundberg (Sweden) Thomas Pap (Germany) Xenofon Baraliakos (Germany) Gary MacFarlane (UK) Editorial Office David Pisetsky (USA) Anne Barton (UK) Xavier Mariette (France) Annals of the Rheumatic Diseases Maarten Boers (The Alberto Martini (Italy) Désirée van der Heijde BMJ Journals, BMA House, Tavistock Square (The Netherlands) Netherlands) Dennis McGonagle (UK) London WCIH 9JR,UK Kazuhiko Yamamoto (Japan) Matthew Brown (Australia) Fred Miller (USA) Maya Buch (UK) Peter Nash (Australia) E: [email protected] Methodological and Statistical Loreto Carmona (Spain) Michael Nurmohamed (The Advisor Carlo Chizzolini (Switzerland) Netherlands) Production Editor Stian Lydersen (Norway) Bernard Combe (France) Caroline Ospelt (Switzerland) Teresa Jobson Philip Conaghan (UK) Monika Østensen (Norway) Social Media Editor E: [email protected] Harrison Austin (UK) Maurizio Cutolo (Italy) Constatino Pitzalis (UK) José da Silva (Portugal) Jane Salmon (USA) Social Media Advisors Nicola Dalbeth (Australia) Georg Schett (Germany) EULAR Alessia Alunno (Italy) Christian Dejaco (Austria) Hendrik Schulze-Koops (Germany) EULAR Executive Secretariat Mary Canavan (Ireland) Oliver Distler (Switzerland) Nan Shen (China) Seestrasse 240, 8802 Kilchberg, Switzerland Meghna Jani (UK) Thomas Dörner (Germany) Alexander So (Switzerland) E: [email protected] Elena Nikiphorou (UK) Dirk Elewaut (Belgium) Zoltan Syekanecz (Hungary) www.eular.org Caroline Ospelt (Switzerland) Axel Finckh (Switzerland) Hiroshi Takayanagi (Japan) Tsutomu Takeuchi (Japan) Christophe Richez (France) Roy Fleischmann (USA) Customer support Mary Goldring (USA) Yoshiya Tanaka (Japan) Paul Studenic (Austria) Juan Gomez-Reino (Spain) Ronald van Vollenhoven (Sweden) For general queries and support with existing and Guidelines for Authors and Laure Gossec (France) Dimitrios Vassilopoulos (Greece) new subscriptions: Reviewers Walter Grassi (Italy) Douglas Veale (Ireland) W: support.bmj.com Ahmet Gül (Turkey) Jiri Vencovsky (Czech Republic) T: +44 (0)20 7111 1105 Full instructions are available Erwin Wagner (Spain) Frederic Houssiau (Belgium) E: [email protected] online at http://ard.bmj.com/ Tom Huizinga (The Netherlands) Michael Ward (USA) Arthur Kavanaugh (USA) Kevin Winthrop (USA) pages/authors. Articles must Self-archiving and permissions be submitted electronically at Chairman of Advisory W: bmj.com/company/products-services/ http://mc.manuscriptcentral. Committee rights-and-licensing/ com/ard. Authors retain copyright Johannes Bijlsma E: [email protected] but are required to grant ARD (The Netherlands) an exclusive licence to publish. Advertising (http://authors.bmj.com/ Advisory Committee W: bmj.com/company/for-advertisers- Ferry Breedveld (The Netherlands) Zhan-guo Li (China) policies/copyright-and-authors-rights). Marco Matucci Cerinic (Italy) Peter Lipsky (USA) and-sponsor/ Michael Doherty (UK) Sir Ravinder Maini (UK) Display Advertising ROW Maxime Dougados (France) Emilio Martín-Mola (Spain) Paul Emery (UK) Haralampos Moutsopoulos Sophie Fitzsimmons Daniel Furst (USA) (Greece) T: +44 (0)20 3655 5612 Steffen Gay (Switzerland) Karel Pavelka (Czech Republic) E: sfi[email protected] Marc Hochberg (USA) Yehuda Shoenfeld (Israel) Joachim Kalden (Germany) Leo van de Putte (The Netherlands) Online Advertising ROW Edward Keystone (Canada) Frank Wollheim (Sweden) Marc Clifford Lars Klareskog (Sweden) Anthony Woolf (UK) T: +44 (0) 20 3655 5610 Tore Kvien (Norway) E: [email protected] Display & Online Advertising Americas American Medical Communications (AMC) T: +1 973 214 4374 Subscription Information E: [email protected] ARD is published monthly; subscribers receive all supplements Reprints ISSN 0003-4967 (print); 1468-2060 (online) Author Reprints Institutional Rates 2019 Personal Rates 2019 BMJ Reprints Team E: [email protected] Print Print (includes online access at no additional cost) Commercial Reprints ROW £1036 £428 Nadia Gurney-Randall M: +44 07866 262344 Online Online only £182 E: [email protected] Site licences are priced on FTE basis and allow access by the whole institution. Details available EULAR congress delegates Commercial Reprints Americas online at http://journals.bmj.com/content/subscribers Delegates receive a Continuous Professional Ray Thibodeau or contact the Subscription Manager in the UK (see Development package that includes a 12 month T: +1 267 895 1758 above right) complimentary subscription to ARD in print M: +1 215 933 8484 and/or online E: [email protected] Personal print or online only and institutional print subscriptions may be purchased online at http://journals.bmj.com/content/ For all other journal contacts subscribers (payment by Visa/Mastercard only) ard.bmj.com/contact-us Residents of some EC countries must pay VAT; for details, call us or visit http://journals.bmj.com/content/subscribers For more information on subscription rates or to subscribe online please visit ard/bmj.com/pages/contact-us/ Contents Volume 78 Issue 5 | ARD May 2019 ARDThe Eular Journal May 2019 Volume 78 Issue 5 Editorial Systemic lupus erythematosus Impact Factor 12.350 581 Time to change the primary outcome of lupus 629 Lupus Low Disease Activity State (LLDAS) trials discriminates responders in the BLISS-52 F A Houssiau and BLISS-76 phase III trials of belimumab in systemic lupus erythematosus S Oon, M Huq, V Golder, P X Ong, E F Morand, Heroes and pillars of rheumatology M Nikpour 583 Jan Gösta Waldenström and rheumatology F A Wollheim 634 Multicriteria decision analysis process to develop new classification criteria for systemic lupus erythematosus Rheumatoid arthritis S K Tedeschi, S R Johnson, D T Boumpas, D Daikh, 586 Normal mortality of the COBRA early T Dörner, B Diamond, S Jacobsen, D Jayne, Editor rheumatoid arthritis trial cohort after 23 years D L Kamen, W J McCune, M Mosca, Josef S Smolen R Ramsey-Goldman, G Ruiz-Irastorza, of follow-up Associate Editors M Schneider, M Urowitz, D Wofsy, J S Smolen, P BM Poppelaars, L H D van Tuyl, M Boers Trisan Barber R P Naden, M Aringer, K H Costenbader Francis Berenbaum Dimitrios Boumpas Gerd Burmester 590 Prevotella copri in individuals at risk for Mary Crow rheumatoid arthritis Iain McInnes Sjögren’s syndrome Thomas Pap D Alpizar-Rodriguez, T R Lesker, A Gronow, 641 Treatment of primary Sjögren’s syndrome with David Pisetsky B Gilbert, E Raemy, C Lamacchia, C Gabay, Désirée van der Heijde ianalumab (VAY736) targeting B cells by BAFF Kazuhiko Yamamoto A Finckh, T Strowig receptor blockade coupled with enhanced, Editorial office Annals of the Rheumatic Diseases 594 Porphyromonas gingivalis experimentally antibody-dependent cellular cytotoxicity BMJ Publishing Group Ltd induces periodontis and an anti-CCP2- T Dörner, M G Posch, Y Li, O Petricoul, BMA House M Cabanski, J M Milojevic, E Kamphausen, Tavistock Square associated arthritis in the rat M-A Valentin, C Simonett, L Mooney, A Hüser, London WCIH 9JR,UK G Courbon, M Rinaudo-Gaujous, V Blasco-Baque, T: +44 (0)20 3655 5889 H Gram, F D Wagner, S J Oliver E: [email protected] I Auger, R Caire, L Mijola, L Vico, S Paul, Twitter: @ARD_BMJ H Marotte ISSN: 0003-4967 (print) ISSN: 1468-2060 (online) Impact Factor: 12.350 600 PTPN14 phosphatase and YAP promote TGFβ Systemic sclerosis 648 Progressive skin fibrosis is associated with Disclaimer: ARD is owned and published by signalling in rheumatoid synoviocytes BMJ Publishing Group Ltd (a wholly owned a decline in lung function and worse survival subsidiary of the British Medical Association) A Bottini, D J Wu, R Ai, M Le Roux, B Bartok, and the European League Against Rheumatism. The M Bombardieri, K M Doody, V Zhang, C Sacchetti, in patients with diffuse cutaneous systemic owners grant editorial freedom tothe Editor of ARD. ARD follows guidelines on editorial independence M Zoccheddu, A Lonic, X Li, D L Boyle, sclerosis in the European Scleroderma Trials produced by the World Association of Medical Editors D Hammaker, T-C Meng, L Liu, M Corr, and the code on good publication practice of the and Research (EUSTAR) cohort Committee on Publication Ethics. S M Stanford, M Lewis, W Wang, G S Firestein, W Wu, S Jordan, N Graf, J de Oliveira Pena, ARD is intended for medical professionals and is Y Khew-Goodall, C Pitzalis, N Bottini provided without warranty, express or implied. J Curram, Y Allanore, M Matucci-Cerinic, J E Pope, Statements in the journal are the responsibility C P Denton, D Khanna, O Distler, EUSTAR of their authors and advertisers and not authors’ institutions the BMJ Publishing Group, the Collaborators European League Against Rheumatism or the BMA unless otherwise specified or determined Psoriatic arthritis by law. Acceptance of advertising does not imply endorsement. 610 Achieving remission in psoriatic arthritis by To the fullest extent permitted by law, the BMJ early initiation of TNF inhibition: a double- Publishing Group shall not be liable for any loss, injury or damage resulting from the use of ARD or any blind, randomised, placebo-controlled trial of information
Recommended publications
  • A Novel Approach to the Development of Response Criteria for Chronic Gout Clinical Trials
    Bringing It All Together: A Novel Approach to the Development of Response Criteria for Chronic Gout Clinical Trials WILLIAM J. TAYLOR, JASVINDER A. SINGH, KENNETH G. SAAG, NICOLA DALBETH, PATRICIA A. MacDONALD, N. LAWRENCE EDWARDS, LEE S. SIMON, LISA K. STAMP, TUHINA NEOGI, ANGELO L. GAFFO, PUJA P. KHANNA, MICHAEL A. BECKER, and H. RALPH SCHUMACHER Jr ABSTRACT. Objective. To review a novel approach for constructing composite response criteria for use in chronic gout clinical trials that implements a method of multicriteria decision-making. Methods. Preliminary work with paper patient profiles led to a restricted set of core-set domains that were examined using 1000MindsTM by rheumatologists with an interest in gout, and (separately) by OMERACT registrants prior to OMERACT 10. These results and the 1000Minds approach were dis- cussed during OMERACT 10 to help guide next steps in developing composite response criteria. Results. There were differences in how individual indicators of response were weighted between gout experts and OMERACT registrants. Gout experts placed more weight upon changes in uric acid levels, whereas OMERACT registrants placed more weight upon reducing flares. Discussion highlighted the need for a “pain” domain to be included, for “worsening” to be an additional level within each indica- tor, for a group process to determine the decision-making within a 1000Minds exercise, and for the value of patient involvement. Conclusion. Although there was not unanimous support for the 1000Minds approach to inform the con- struction of composite response criteria, there is sufficient interest to justify ongoing development of this methodology and its application to real clinical trial data.
    [Show full text]
  • Biologic Drugs in the Treatment of Myositis
    BIOLOGIC DRUGS IN THE TREATMENT OF MYOSITIS Professor David Isenberg University College London, UK KEY FACTS – 1 - • Incidence of PM/DM/IBM 1.9-7.7 million • Prevalence in the UK = 8/100,000 • Affects all ages but 2 peaks of onset; childhood onset 5-15 and adult onset 40-60. IBM peaks after 50 years. • DM/PM overall F:M ratio = 2-3:1 KEY FACTS – 2 – CLINICAL CLASSIFICATION • Adult onset idiopathic polymyositis • Adult onset idiopathic dermatomyositis • Childhood onset myositis (invariably dermatomyositis) • Myositis associated with other autoimmune rheumatic disease • Inclusion body myositis • Rare forms: focal, ocular, eosinophilic, granulomatous myositis • Cancer associated myositis KEY FACTS – 3 – A MULTISYSTEM DISEASE • Constitutional – fever, wt loss, nodes, fatigue • Joints – arthralgia, arthritis • Gastrointestinal – dysphagia, abdo pain • Cardiovascular – palpitations, chest pain SKIN – RASHES, ERYTHEMA, ULCERATION AND ERYTHRODERMA MUSCLE – MYALGIA, WEAKNESS Polymyositis: histopathological features Mechanisms in Rheumatology ©2001 Dermatomyositis: histopathological features Mechanisms in Rheumatology ©2001 Respiratory – dysphonia, dyspnoea TRADITIONAL METHODS OF ASSESSING MYOSITIS Clinical Enzymes EMG Biopsy ACTIVITY- MITAX ASSESSMENT OF OUTCOME Idiopathic Inflammatory myopathies PATIENT’S DAMAGE- PERCEPTION- MYODAM SF-36 CURRENT ASSESSMENT OF MYOSITIS – 1 - Activity Damage Clinical rash, arthritis, fever, MMT, Atrophy, contractures myalgia Laboratory ↑ Muscle enzymes ↓ Creatinine, normal (CK, LDH, AST, ALT) enzymes Systemic
    [Show full text]
  • Copecare Publications 2016
    COPECARE PUBLICATIONS 2016 JOURNAL PAPERS 2 LETTERS 10 REVIEWS 10 COMMENTS/DEBATES 10 CONFERENCE ABSTRACTS 11 BOOKS 22 REPORTS 22 PH.D. THESES 22 BOOK CHAPTERS/ANTHOLOGIES 22 POSTERS 23 NEWSPAPER ARTICLES 23 ONLINE PUBLICATIONS 23 OTHER PUBLICATIONS 24 Journal papers Three-dimensional Doppler ultrasound findings in healthy wrist and finger tendon sheaths - can feeding vessels lead to misinterpretation in Doppler-detected tenosynovitis? Ammitzbøll-Danielsen, M., Janta, I., Torp-Pedersen, S., Naredo, E., Østergaard, M. & Terslev, L., 18 mar. 2016, I : Arthritis Research and Therapy. 18, s. 70-77 7 s. Validity and sensitivity to change of the semi-quantitative OMERACT ultrasound scoring system for tenosynovitis in patients with rheumatoid arthritis Ammitzbøll-Danielsen, M., Østergaard, M., Naredo, E. & Terslev, L., dec. 2016, I : Rheumatology (Oxford, England). 55, 12, s. 2156-66 11 s. Associations between spondyloarthritis features and MRI findings: A cross-sectional analysis of 1020 patients with persistent low back pain Arnbak, B., Jurik, A. G., Hørslev-Petersen, K., Hendricks, O., Hermansen, L. T., Loft, A. G., Østergaard, M., Pedersen, S. J., Zejden, A., Egund, N., Holst, R., Manniche, C. & Jensen, T. S., 2016, I : Arthritis & rheumatology (Hoboken, N.J.). 68, 4, s. 892-900 9 s. The discriminative value of inflammatory back pain in patients with persistent low back pain Arnbak, B., Hendricks, O., Hørslev-Petersen, K., Jurik, A. G., Pedersen, S. J., Østergaard, M., Hermansen, L. T., Loft, A. G., Jensen, T. S. & Manniche, C., jul. 2016, I : Scandinavian Journal of Rheumatology. 45, 4, s. 321-8 8 s. Validity of early MRI structural damage end points and potential impact on clinical trial design in rheumatoid arthritis Baker, J.
    [Show full text]
  • Autumn 2016 Meeting Booklet
    Welcome Message from the ISR President Dr Sandy Fraser Dear Colleagues and Friends I have great pleasure in welcoming you all to The Killashee Hotel Naas for this year’s ISR Autumn Meeting. The programme for this year’s autumn meeting has been put together by our colleagues in Beaumont hospital, Dr Donough Howard, Dr Grainne Kearns and Dr Paul O’Connell and I think you will agree that it is a fascinating agenda addressing topics which are of interest to all of us. I look forward with great interest to hear the thoughts of Professor Dennis McGonagle , Professor of Investigative Rheumatology, Leeds Institute of Rheumatic and Musculoskeletal Medicine and indeed Dr Bruce Kirkham, consultant Rheumatologist at Guys and St. Thomas’ NHS Foundation Trust. Professor Sean Gaine from The Mater Misericordiae Hopital Dublin will present on the current management of pulmonary hypertension and Dr. Patrick Kiely from St Georges Hospital London will help us to pick the right biologic for our patients. Finally Professor Donal O’Shea from St. Vincents Hospital Dublin will address the issue of obesity and its relationship to inflammation. During the year the work of the ISR has continued unabated and Professor David Kane, as National Programme Director, has continued to develop the National Rheumatology Programme with consensus and inclusivity core to the process. The steering group (CAG – Clinical Advisory Group) for the programme is open to all members of the ISR and the last meeting at the spring meeting in Cork was very well attended and very productive and there was a great deal of agreement regarding the direction the programme should lead.
    [Show full text]
  • MEDICALBJOURNAL Birthis, MARRIAGES, and DEATHS
    1558 DEC. 28, 1957 MEDICAL NEWS MEDICALBJOURNAL aged sick, and £25.000 for grants to convalescent homes. Van Meter Prize.-The American Goiter Association Sir ARCHIBALD GRAY said the distribution committee had again offers the Van Meter Prize Award of $300 and two made a grant of £10,000 to the British Student Tuberculosis honourable mentions for the best essays on originial work Foundation. This Foundation had been started, he said, on problems related to the thyroid gland. Essays may cover entirely by university students, who since 1950 had collected either clinical or research investigations, should not exceed something like £35,000 to help students with pulmonary 3,000 words in length, and must be presented in English. tuberculosis. Up to the present, accommodation had been Duplicate typewritten copies, double spaced, should be sent in two centres outside London, to which it was difficult for to Dr. JOHN C. MCCLINTOCK, 149}, Washington Avenue, tutors from the various colleges to travel. Mottingham Albany, 10, New York, not later than February 1. Hall, in the grounds of Grove Park Hospital, Lewisham, Medical Auxiliaries.-Recognition was granted by the was now to be converted into a hostel, taking about 35 Board of Registration during 1956-7 to the Society of ambulant cases, and there would be two wards in Grove Audiology Technicians and the Institute of Technicians in Park Hospital for those who had to be hospitalized. The Venereology, it is stated in the Board's annual report. students would thus get much better accommodation, with During the year registers of orthoptists, operating theatre a resident warden, and be within easy reach of the various technicians, and dispensing opticians were published.
    [Show full text]
  • Autoinflammatory Disease Damage Index, 2016
    Downloaded from http://ard.bmj.com/ on September 1, 2017 - Published by group.bmj.com Clinical and epidemiological research EXTENDED REPORT Development of the autoinflammatory disease damage index (ADDI) Nienke M ter Haar,1,2 Kim V Annink,3 Sulaiman M Al-Mayouf,4 Gayane Amaryan,5 Jordi Anton,6 Karyl S Barron,7 Susanne M Benseler,8 Paul A Brogan,9 Luca Cantarini,10 Marco Cattalini,11 Alexis-Virgil Cochino,12 Fabrizio De Benedetti,13 Fatma Dedeoglu,14 Adriana A De Jesus,15 Ornella Della Casa Alberighi,16 Erkan Demirkaya,17 Pavla Dolezalova,18 Karen L Durrant,19 Giovanna Fabio,20 Romina Gallizzi,21 Raphaela Goldbach-Mansky,15 Eric Hachulla,22 Veronique Hentgen,23 Troels Herlin,24 Michaël Hofer,25,26 Hal M Hoffman,27 Antonella Insalaco,28 Annette F Jansson,29 Tilmann Kallinich,30 Isabelle Koné-Paut,31 Anna Kozlova,32 Jasmin B Kuemmerle-Deschner,33 Helen J Lachmann,34 Ronald M Laxer,35 Alberto Martini,36 Susan Nielsen,37 Irina Nikishina,38 Amanda K Ombrello,39 Seza Ozen,40 Efimia Papadopoulou-Alataki,41 Pierre Quartier,42 Donato Rigante,43 Ricardo Russo,44 Anna Simon,45 Maria Trachana,46 Yosef Uziel,47 Angelo Ravelli,48 Marco Gattorno,49 Joost Frenkel3 Handling editor Tore K Kvien ABSTRACT INTRODUCTION Objectives Autoinflammatory diseases cause systemic Autoinflammatory diseases (AIDs) cover a spectrum For numbered affiliations see fl end of article. in ammation that can result in damage to multiple of diseases, which lead to chronic or recurrent organs. A validated instrument is essential to quantify inflammation caused by activation of the innate Correspondence to damage in individual patients and to compare disease immune system, typically in the absence of high- 1 Dr Nienke M ter Haar, outcomes in clinical studies.
    [Show full text]
  • 2010 Rheumatoid Arthritis Classification Criteria
    ARTHRITIS & RHEUMATISM Vol. 62, No. 9, September 2010, pp 2569–2581 DOI 10.1002/art.27584 © 2010, American College of Rheumatology Arthritis & Rheumatism An Official Journal of the American College of Rheumatology www.arthritisrheum.org and www.interscience.wiley.com 2010 Rheumatoid Arthritis Classification Criteria An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative Daniel Aletaha,1 Tuhina Neogi,2 Alan J. Silman,3 Julia Funovits,1 David T. Felson,2 Clifton O. Bingham, III,4 Neal S. Birnbaum,5 Gerd R. Burmester,6 Vivian P. Bykerk,7 Marc D. Cohen,8 Bernard Combe,9 Karen H. Costenbader,10 Maxime Dougados,11 Paul Emery,12 Gianfranco Ferraccioli,13 Johanna M. W. Hazes,14 Kathryn Hobbs,15 Tom W. J. Huizinga,16 Arthur Kavanaugh,17 Jonathan Kay,18 Tore K. Kvien,19 Timothy Laing,20 Philip Mease,21 Henri A. Ménard,22 Larry W. Moreland,23 Raymond L. Naden,24 Theodore Pincus,25 Josef S. Smolen,1 Ewa Stanislawska-Biernat,26 Deborah Symmons,27 Paul P. Tak,28 Katherine S. Upchurch,18 Jirˇí Vencovsky´,29 Frederick Wolfe,30 and Gillian Hawker31 This criteria set has been approved by the American College of Rheumatology (ACR) Board of Directors and the Euro- pean League Against Rheumatism (EULAR) Executive Committee. This signifies that the criteria set has been quantita- tively validated using patient data, and it has undergone validation based on an external data set. All ACR/EULAR- approved criteria sets are expected to undergo intermittent updates. The American College of Rheumatology is an independent, professional, medical and scientific society which does not guarantee, warrant, or endorse any commercial product or service.
    [Show full text]
  • Social Media & Medicine Focus On
    Fall 2013, Volume 23, Number 3 The Journal of the Canadian Rheumatology Association Focus on Social Media & Medicine Editorial • Freedom 55 Awards, Appointments, Regional News and Accolades • Rheumatology in Saint John, New Brunswick • Celebrating Dr. Robert Inman, Mr. Jean Légaré, • Greetings from Moncton Dr. Diane Lacaille, Mr. Daniel Longchamps, Dr. Dianne Mosher, and Dr. Rachel Shupak Joint Communiqué • EULAR 2013 Impression & Opinion • Canadian Rheumatology Association / Mexican • Using EMRs to Connect with Patients in Daily College of Rheumatology Update: 2013 Rheumatology Clinical Practice • Utilization of Musculoskeletal Ultrasound in Daily • Use of Technology and Medico-Legal Issues Rheumatology Practice and Research • Rhediant Diagnostic Software • Communicating With Seniors: A Workshop for • Mobile Apps For Your Practice Nursing Staff • RheumInfo.com • Some Thoughts on Social Media In Memoriam • Patient Communication via MyDoctor.ca • James Richard Topp Northern (High)Lights Hallway Consult • Abraham Shore Memorial Lectureship • If It’s Not One Thing, It’s Another: Transformation • Rheumatology Choosing Wisely of Lupus Nephritis What Is the CRA Doing For You? Top Ten Things Rheumatologists Should (And Might Not) Know About... • RA Guidelines: Practice Patterns of Rheumatologists in Canada Compared to CRA • Pain Recommendations for RA (Part II) The CRAJ is online! You can find us at: www.stacommunications.com/craj.html EDITORIAL Freedom 55 By Philip A. Baer, MDCM, FRCPC, FACR “Give me your answer, fill in a form Mine for evermore Will you still need me, will you still feed me When I'm sixty-four?” - Lennon-McCartney, “When I’m 64”, Sgt. Pepper’s Lonely Hearts Club Band , 1966. itting in my office, seeing a steady stream of patients, And here I thought I was doing particularly well with my I feel a gratifying sense of control and mastery most chronic inflammatory disease patients.
    [Show full text]
  • Dr Barbara Mary Ansell
    Archives of Disease in Childhood 1997;77:279–280 279 Arch Dis Child: first published as 10.1136/adc.77.4.279 on 1 October 1997. Downloaded from ARCHIVES OF DISEASE IN CHILDHOOD The Journal of the Royal College of Paediatrics and Child Health James Spence Medallist 1997 Dr Barbara Mary Ansell At the first Annual Meeting of the Royal College of Paedi- atrics and Child Health, in April at the University of York, the President, Professor Sir Roy Meadow, presented the James Spence Medal to Dr Barbara Ansell, with this citation. 1997 is the 100th Anniversary of George Frederic Still’s description of chronic joint disease in children. At least seven diVerent forms of idiopathic arthritis that commence in childhood are now recognised, and no-one has done more than today’s James Spence Medallist in defining these disorders and improving their management. Dr Barbara Ansell fulfils to the limit the criteria by which our premier award, the James Spence Medal, is awarded—for outstand- ing contributions to the advancement or clarification of http://adc.bmj.com/ paediatric knowledge. Barbara Ansell was educated at King’s High School for Girls in Warwick before entering, as a medical student, Birmingham University, from which she qualified in 1946. Thus, she has experienced the first 50 years of the National Health Service, and in many ways she exemplifies all that has been best about our health service in its first 50 years—the development of specialty services and, in on October 1, 2021 by guest. Protected copyright. particular, specialty services for children, the development of child and family centred services, the advent of clinical trials, the delivery of care for chronic disorders by multidisciplinary teams, and the availability of expert care on an equitable basis, and (though I hope it does not sound patronising) one of the most important aspects of today’s health service, the stature and role of women doctors, for whom opportunities previously were so limited.
    [Show full text]
  • Update on Outcome Assessment in Myositis
    FOCUS ON MYOSITISREVIEWS Update on outcome assessment in myositis Lisa G. Rider1*, Rohit Aggarwal2, Pedro M. Machado3, Jean-Yves Hogrel4, Ann M. Reed5, Lisa Christopher-Stine6 and Nicolino Ruperto7 Abstract | The adult and juvenile myositis syndromes, commonly referred to collectively as idiopathic inflammatory myopathies (IIMs), are systemic autoimmune diseases with the hallmarks of muscle weakness and inflammation. Validated, well-standardized measures to assess disease activity, known as core set measures, were developed by international networks of myositis researchers for use in clinical trials. Composite response criteria using weighted changes in the core set measures of disease activity were developed and validated for adult and juvenile patients with dermatomyositis and adult patients with polymyositis, with different thresholds for minimal, moderate and major improvement in adults and juveniles. Additional measures of muscle strength and function are being validated to improve content validity and sensitivity to change. A health-related quality of life measure, which incorporates patient input, is being developed for adult patients with IIM. Disease state criteria, including criteria for inactive disease and remission, are being used as secondary end points in clinical trials. MRI of muscle and immunological biomarkers are promising approaches to discriminate between disease activity and damage and might provide much-needed objective outcome measures. These advances in the assessment of outcomes for myositis treatment, along with collaborations between international networks, should facilitate further development of new therapies for patients with IIM. Patient-reported outcome The idiopathic inflammatory myopathies (IIMs), comprising clinicians and researchers with a special measures also known as myositis, are a diverse group of auto­ interest in IIM, which include the International Myositis (PROMs).
    [Show full text]
  • Downloaded and Imported Into an Excel Data- Discussions in the Four Breakout Groups Were Moder- Base
    Hunter et al. BMC Musculoskeletal Disorders (2019) 20:74 https://doi.org/10.1186/s12891-019-2455-x RESEARCH ARTICLE Open Access Developing strategic priorities in osteoarthritis research: Proceedings and recommendations arising from the 2017 Australian Osteoarthritis Summit David J. Hunter1,4* , Philippa J. A. Nicolson2, Christopher B. Little3, Sarah R. Robbins1, Xia Wang1 and Kim L. Bennell2 Abstract Background: There is a pressing need to enhance osteoarthritis (OA) research to find ways of alleviating its enormous individual and societal impact due to the high prevalence, associated disability, and extensive costs. Methods: Potential research priorities and initial rankings were pre-identified via surveys and the 1000Minds process by OA consumers and the research community. The OA Summit was held to decide key research priorities that match the strengths and expertise of the Australian OA research community and align with the needs of consumers. Facilitated breakout sessions were conducted to identify initiatives and strategies to advance OA research into agreed priority areas, and foster collaboration in OA research by forming research networks. Results: From the pre-Summit activities, the three research priority areas identified were: treatment adherence and behaviour change, disease modification, and prevention of OA. Eighty-five Australian and international leading OA experts participated in the Summit, including specialists, allied health practitioners, researchers from all states of Australia representing both universities and medical research institutes; representatives from Arthritis Australia, health insurers; and persons living with OA. Through the presentations and discussions during the Summit, there was a broad consensus on the OA research priorities across stakeholders and how these can be supported across government, industry, service providers and consumers.
    [Show full text]
  • Jasvinder Singh, MD
    Singh, Jasvinder MD, MPH CURRICULUM VITAE Date: April 30, 2020 PERSONAL INFORMATION: Name: Jasvinder A. Singh, MD, MPH Citizenship: U.S.A. RANK/TITLE: Departments: ! Endowed Professor, Musculoskeletal Outcomes Research Professor of Medicine and Epidemiology with Tenure Staff Physician, Birmingham VA Medical Center Business Address: ! University of Alabama at Birmingham Faculty Office Tower 805B 510 20th Street South Birmingham, AL 35294 HOSPITAL AND OTHER (NON ACADEMIC) APPOINTMENTS: 2009-present ! Staff Physician University of Alabama Hospital and University of Alabama Health Services Foundation 2009-present ! Staff Physician, Medical Service - Rheumatology Veterans Affairs (VA) Medical Center, Birmingham, Alabama 2009-present ! Staff Physician UAB Highlands Hospital, Birmingham, Alabama 2009-2012 ! Staff Physician Cooper Green Mercy Hospital, Birmingham, Alabama 2001- 2009 ! Staff Physician, Medical Service - Rheumatology Veterans Affairs (VA) Medical Center, Minneapolis, Minnesota EDUCATION: 2001-2003 ! Master of Public Health (Epidemiology) University of Minnesota, Minneapolis, MN 1988-1993 ! Bachelor of Medicine and Bachelor of Surgery (M.B.B.S.) University College of Medical Sciences, New Delhi, India POSTDOCTORAL TRAINING: 1998-2001 ! Rheumatology Fellowship, Division of Rheumatology and Immunology 1 Singh, Jasvinder MD, MPH Washington University School of Medicine, St. Louis, Missouri 1995-1998 ! Internship and Residency, Internal Medicine State University of New York (SUNY), Syracuse, New York 1994 Residency, Department of Psychiatry
    [Show full text]