Shiseido Wins World-Leading 15Th Top Award from IFSCC —Latest Award for Novel Eye Patch Delivering Hyaluronic Acid Directly in the Skin (Stratum Corneum)—

2011 December

Shiseido Wins World-Leading 15th Top Award from IFSCC —Latest Award for Novel Eye Patch Delivering Hyaluronic Acid Directly In the Skin (Stratum Corneum)—

From December 12 to December 14, 2011, IFSCC*1 hosted the IFSCC Conference 2011 in Bangkok, Thailand. In this event to select the world’s best cosmetics, skin and related research achievements, Shiseido won the exclusive top award for an oral presentation. This year’s 127 theme presentations (52 oral presentations, 75 poster presentations) were submitted from 16 countries*2 worldwide. This latest award is the 15th top award granted by the IFSCC to Shiseido, which has earned more of them than any other cosmetic manufacturer. Research details and results presented at the IFSCC are recognized by leading cosmetics research experts throughout the world. Top award winners are selected after evaluation of their research from various perspectives, including details of the effects, mechanisms and broad applications to expand cosmetics development. This activity promotes the spirit of innovation in research.

*1 The International Federation of Societies of Cosmetic Chemists *2 Based on IFSCC official website (as of November 2011)

Overview of the Theme that Won the Top Award [Theme] Development of self-dissolving microneedles consisting of hyaluronic acid as an anti-wrinkle treatment [Award Recipient] Yukiko Matsunaga, Researcher (Innovative Science Research & Development Center), Shiseido Research Center [Summary] Shiseido successfully developed an eye patch showing effective improvement of wrinkles, which was used self-dissolving microneedle technology. Microneedle technology is a newly advanced system for drug delivery and has been recently gained increased attention to its painless manner and safety in the medical field. We applied this microneedle technology to cosmetics as larger eye patch*3 with appropriate size and shape, in which 1200 needles were aligned on the surface (Image). Needles consist of hyaluronic acid which is essential to maintaining skin moisture and elasticity and known to decrease with aging..Successive administration of this patch preparation to the eye corner resulted in significant improvements of wrinkles, with increases of water content in the stratum corneum and viscoelasticity, which is an index of resilience.*4 The patch applied these results have been commercialized in HA Fill Patch (launched in March 2011) by NAVISION*5 brand for medical cosmetic treatment.

*3 Self-dissolving type, in which the needles melt by skin temperature and moisture. *4 Used twice a week for 4 weeks at the eye corners of 26 healthy female volunteers ranging in age from 30s to 50s. *5 Cosmetics brand launched in the market in November 2005 for medical cosmetic treatment (11 items for doctor-use products, 28 items for home-use products); http://www.shiseido.co.jp/navision/ (only in Japan)

Enlarged photo using an electron microscope

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Lengths of needle : Approximately 0.02 millimeter

（Image）Currently developed patch preparation for the eye area (Overall image and enlarged photo using an electron microscope)

IFSCC and Shiseido In 1959, cosmetics chemists from eight countries founded the IFSCC with the aim of sharing information internationally for the development of cosmetics technologies. The organization currently has approximately 15,000 members in 47 countries. IFSCC Congresses are held once every two years on even-numbered years. With nearly 200 research presentations and more than 1,000 participants, the congress is truly recognized as the world’s most authoritative event for presenting research regarding cosmetics and skin. Furthermore, since 2003, a top award has been presented to one most outstanding research presentation at the IFSCC Conferences, which are held on odd-numbered years to educate young researchers and enhance the awareness of developing country members. Having accumulated a total of 15 top IFSCC Congress and IFSCC Conference awards*6, Shiseido is the recipient of more of these awards than any other cosmetic manufacturer in the world. The awards validate that Shiseido takes leading research and development initiative in the global cosmetics industry, earns high regard for the technologies it has accumulated, and contributes to the creation of safe, reassuring, high quality products that its competitors cannot imitate.

*6 Top awards received by Shiseido are listed hereinafter.

2 Lecture Invitations At this year’s IFSCC Conference 2011, Shiseido was invited to present lectures directed toward the global development of cosmetic science in addition to the three academic presentations. The details of two lectures are follows.

(1) Basic theory regarding skin whitening Kiyoshi Sato,Senior Scientist (Skincare Product Research & Development Center), Shiseido Research Center

(2) Keynote lecture of new dermatological science Dr. Chika Katagiri, Senior Scientist (Innovative Science Research & Development Center), Shiseido Research Center The latest dermatological development and corresponding novel ingredients, which are also applied to Shiseido Future Solution LX, that fundamentally improves skin quality and leads to beautiful skin by inhibiting harmful protein Serpin b3 (Lecture title: Identification of a regulatory molecule of barrier disruption and its influence on skin function)

3 1. List of Top Awards Received by Shiseido at IFSCC Congress

Year Congress Location Theme Presentation Form 1 1976 9th Boston, USA Research into, and application of, water-in-oil Oral Presentation Congress emulsions stabilized with amino acids or their salts 2 1986 14th Barcelona, Development of a new type of colored nacreous Oral Presentation Congress Spain pigment 3 1988 15th London, UK Elucidating body malodor to develop a novel Oral Presentation Congress body odor quencher 4 1990 16th New York, Development of a new W/O-type nail enamel Oral Presentation Congress USA 5 1992 17th Yokohama, Measurement method of efficacy of anti-dandruff Oral Presentation Congress Japan cosmetics and development of a new active commercial product 6 2000 21st Berlin, Research related to dermal-epidermal basement Oral Presentation Congress Germany membrane care 7 Development of super-rapid drying “dip in water” Poster Presentation nail enamel 8 2002 22nd Edinburgh, UK Development of “Skincare Powder” as an Oral Presentation Congress ingredient inhibiting dry skin 9 2006 24th Osaka, Japan How can we improve the appearance of Poster Presentation Congress conspicuous facial pores? 10 2008 25th Barcelona, Development of high water-resistant / Oral Presentation Congress Spain detergent-washable powder coated with a pH-responsive polymer and its application to suncare products 11 2010 26th Buenos Aires, Characterization and regulatory mechanism of Oral Presentation Congress Argentina bleomycin hydrolase as a natural moisturizing factor (NMF)-generating enzyme in human epidermis 12 Development of lipstick that barely leaves a color Oral Presentation mark on cups using two-phase separation mechanism 13 A novel, self-assembled structure for transparent, Poster Presentation reversibly deformable oil gels and its application to cosmetics

2. List of Top Awards Received by Shiseido at IFSCC Conference

Year Location Theme Presentation Form 1 2005 Florence, Italy Optical Rejuvenating Makeup Using an Oral Presentation Innovative Shape-Controlled Hybrid Powder 2 2011 Bangkok, Thailand Development of self-dissolving microneedles Oral Presentation (Currently consisting of hyaluronic acid as anti-wrinkle awarded) treatment