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Potassium Chloride Extended-Release Tablets

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Potassium Chloride Extended-Release Tablets Potassium Chloride Extended-Release Tablets Type of Posting Revision Bulletin Posting Date 20–Aug–2019 Official Date 21–Aug–2019 Expert Committee Chemical Medicines Monographs 5 Reason for Revision Compliance In accordance with the Rules and Procedures of the 2015–2020 Council of Experts, the Chemical Medicines Monographs 5 Expert Committee has revised the Potassium Chloride Extended-Release Tablets monograph. The purpose for the revision is to add Dissolution Test 3 to accommodate FDA- approved drug products with different dissolution conditions and tolerances than the existing dissolution tests. • Dissolution Test 3 was validated using a Dionex IonPac CS12A brand of L106 column from ThermoFisher. The typical retention time for potassium is about 5 min. USP Reference Standards information has been incorporated to support the inclusion of Dissolution Test 3, which includes USP Potassium Chloride RS. The Potassium Chloride Extended-Release Tablets Revision Bulletin supersedes the currently official monograph. Should you have any questions, please contact Ren-Hwa Yeh, Senior Scientific Liaison (301-998-6818 or [email protected]). C207670-M67390-CHM52015, rev 00 20190820 Revision Bulletin Potassium 1 Official August 21, 2019 powdered Tablets, prepared as follows. Transfer an Potassium Chloride Extended-Release appropriate amount of the powder, equivalent to about Tablets 5–6 Tablets, to a suitable volumetric flask, add 10% of the final flask volume of acetone, and sonicate for 45 DEFINITION min with intermittent shaking. Add 80% of the final flask Potassium Chloride Extended-Release Tablets contain NLT volume of water and sonicate for 45 min with 90.0% and NMT 110.0% of the labeled amount of intermittent shaking. Cool to room temperature and potassium chloride (KCl). dilute with water to volume. Centrifuge a portion of the solution at 5000 rpm for 10 min. Transfer an IDENTIFICATION appropriate amount of the supernatant to a 100-mL DENTIFICATION ESTS ENERAL á ñ · A. I T ÐG 191 , Chemical volumetric flask and dilute with water to volume to Identification Tests, Potassium obtain a solution with a concentration of 0.15 mg/mL.] Sample solution: A portion of the filtrate, obtained as Sample solution 2: Nominally 3 µg/mL of potassium directed for the designated Sample stock solution in the chloride prepared as follows. Transfer an appropriate Assay amount of Sample stock solution 2 to a 100-mL Acceptance criteria: Meet the requirements volumetric flask, add 2.0 mL of sodium chloride solution DENTIFICATION ESTS ENERAL á ñ · B. I T ÐG 191 , Chemical (1 in 5) and 1.0 mL of hydrochloric acid, and dilute with Identification Tests, Chloride water to volume. Sample solution: A portion of the filtrate, obtained as Instrumental conditions directed for the designated Sample stock solution in the (See Atomic Absorption Spectroscopy á852ñ.) Assay Mode: Atomic absorption spectrophotometry Acceptance criteria: Meet the requirements Analytical wavelength: Potassium emission line at 766.5 ASSAY nm · PROCEDURE Lamp: Potassium hollow-cathode [NOTE—If necessary, first score nonsugar-coated Flame: Air–acetylene Tablets. Retain a portion of the filtrate of either Blank: Water Sample stock solution 1 or Sample stock solution 2 for Analysis use in Identification A and B.] Samples: Standard solutions, Sample solution 1 or Sample Standard stock solution: 19.07 µg/mL of potassium solution 2, and Blank chloride, previously dried at 105° for 2 h, in water. This Plot the absorbances of the Standard solutions versus the solution contains 10 µg/mL of potassium. concentration of potassium, in µg/mL, and draw the Standard solutions: To separate 100-mL volumetric flasks straight line best fitting the three plotted points. From transfer 10.0, 15.0, and 20.0 mL, respectively, of Standard the graph, determine the concentration of potassium in stock solution. To each flask add 2.0 mL of sodium the Sample solution (µg/mL). chloride solution (1 in 5) and 1.0 mL of hydrochloric acid, Calculate the percentage of the labeled amount of and dilute with water to volume. The Standard solutions potassium chloride (KCl) in each Tablet taken: contain 1.0, 1.5, and 2.0 µg/mL of potassium, respectively. Result = (C/CU) × (Mr/Ar) × 100 Sample preparation 1 Sample stock solution 1: Nominally 0.06 mg/mL of C = concentration of potassium in the Sample potassium chloride prepared as follows. Place NLT 20 solution as determined in this test (µg/mL) Tablets in a suitable container with 400 mL of water, CU = nominal concentration of potassium chloride heat to boiling, and boil for 20 min. Allow to cool, in the Sample solution (µg/mL) transfer the solution to a 1000-mL volumetric flask, and Mr = molecular weight of potassium chloride, dilute with water to volume. Filter and discard the first 74.55 20 mL of the filtrate. Transfer a measured volume of the Ar = atomic weight of potassium, 39.10 subsequent filtrate, equivalent to 60 mg of potassium chloride, to a 1000-mL volumetric flask, and dilute with Acceptance criteria: 90.0%–110.0% water to volume. PERFORMANCE TESTS Sample solution 1: Nominally 3 µg/mL of potassium chloride prepared as follows. Transfer 5.0 mL of Sample Change to read: stock solution 1 to a 100-mL volumetric flask, add 2.0 mL of sodium chloride solution (1 in 5) and 1.0 mL of · DISSOLUTION á711ñ hydrochloric acid, and dilute with water to volume. Test 1 Sample preparation 2 (for formulations containing crystals Medium: Water; 900 mL coated with hydrophobic polymers) Apparatus 2: 50 rpm Sample stock solution 2: Nominally 0.06 mg/mL of Time: 2 h potassium chloride prepared as follows. Place NLT 20 Standard stock solution: 19.07 µg/mL of potassium Tablets in a 2000-mL volumetric flask. Add 1200 mL of a chloride, previously dried at 105° for 2 h, in water. This mixture of acetonitrile and water (1:1), and shake by solution contains 10 µg/mL of potassium. mechanical means, or stir using a magnetic bar for 90 Standard solutions: To separate 100-mL volumetric min. Dilute with the mixture of acetonitrile and water flasks transfer 10.0, 15.0, and 20.0 mL, respectively, of (1:1) to volume. Allow to stand for 90 min. Pass through Standard stock solution. To each flask add 2.0 mL of a filter of 0.2-µm pore size. Transfer a measured volume sodium chloride solution (1 in 5) and 1.0 mL of of the filtrate, and quantitatively dilute with water to hydrochloric acid, and dilute with water to volume. The obtain a solution with a concentration of 0.06 mg/mL. Standard solutions contain, respectively, 1.0, 1.5, and [NOTE—Alternatively, Sample stock solution 2 can be 2.0 µg/mL of potassium. prepared by the following procedure. Nominally 0.15 mg/mL of potassium chloride from NLT 20 finely © 2019 The United States Pharmacopeial Convention All Rights Reserved. C207670-M67390-CHM52015, rev 00 20190820 2 Potassium Revision Bulletin Official August 21, 2019 Sample stock solution: Filter the solution under test, and Sample solution: Transfer 4.0 mL of the Sample stock dilute with Medium to obtain a solution containing solution to a 100-mL volumetric flask. Add 2.0 mL of nominally 60 µg/mL of potassium chloride. sodium chloride solution (1 in 5) and 1.0 mL of Sample solution: Transfer 5.0 mL of the Sample stock hydrochloric acid, and dilute with water to volume. solution to a 100-mL volumetric flask. Add 2.0 mL of Blank solution: To a 100-mL volumetric flask, add 2.0 sodium chloride solution (1 in 5) and 1.0 mL of mL of sodium chloride solution (1 in 5) and 1.0 mL of hydrochloric acid, and dilute with water to volume. hydrochloric acid, and dilute with water to volume. Instrumental conditions Instrumental conditions: Proceed as directed in Test 1, (See Atomic Absorption Spectroscopy á852ñ.) except do not use the Blank. Mode: Atomic absorption spectrophotometry System suitability Analytical wavelength: Potassium emission line at Samples: Standard solutions 766.5 nm Suitability requirements Lamp: Potassium hollow-cathode Linearity: Correlation coefficient NLT 0.99 Flame: Air–acetylene Relative standard deviation: NMT 5.0% from 5 Blank: Water replicate analyses of the 1.5-µg/mL Standard solution Analysis Analysis Samples: Standard solutions, Sample solution, and Blank Samples: 1.5-µg/mL Standard solution, Sample solution, Plot the absorbances of the Standard solutions versus the and Blank solution concentration of potassium, in µg/mL, and draw the Calculate the percentage of the labeled amount of straight line best fitting the three plotted points. From potassium chloride (KCl) dissolved: the graph, determine the concentration of potassium in the Sample solution (µg/mL). Resulti = [(AU/AS) × CS × D × (V/L)] × (Mr/Ar) × 100 Calculate the percentage of the labeled amount of potassium chloride (KCl) dissolved: AU = absorbance of potassium in the Sample solution Result = [C × D × (V/L)] × (Mr/Ar) × 100 AS = absorbance of potassium in the Standard solution C = concentration of potassium in the Sample CS = concentration of potassium in the Standard solution as determined in this test (µg/mL) solution (µg/mL) D = dilution factor of the Sample solution D = dilution factor of the Sample solution V = volume of Medium, 900 mL V = volume of Medium, 900 mL L = labeled amount of potassium chloride (µg/ L = labeled amount of potassium chloride (µg/ Tablet) Tablet) Mr = molecular weight of potassium chloride, Mr = molecular weight of potassium chloride, 74.55 74.55 Ar = atomic weight of potassium, 39.10 Ar = atomic weight of potassium, 39.10 Tolerances: NMT 35% (Q) of the labeled amount of Tolerances: See Table 2. potassium chloride (KCl) is dissolved in 2 h. The requirements are met if the quantities dissolved from the Table 2 Tablets tested conform to Table 1 instead of the table Amount Dissolved (%) shown in Dissolution á711ñ.
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