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Outcomes of Bariatric Surgery in Older Versus Younger Adolescents Sarah B

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Outcomes of Bariatric Surgery in Older Versus Younger Adolescents Sarah B Outcomes of Bariatric Surgery in Older Versus Younger Adolescents Sarah B. Ogle, DO, MS,a Lindel C. Dewberry, MD,a Todd M. Jenkins, PhD, MPH,b Thomas H. Inge, MD, PhD,a Megan Kelsey, MD,a Matias Bruzoni, MD,c Janey S.A. Pratt, MDc OBJECTIVES: In this report, we compare weight loss, comorbidity resolution, nutritional abstract abnormalities, and quality of life between younger and older adolescents after metabolic and bariatric surgery. METHODS: From March 2007 to December 2011, 242 adolescents (#19 years of age) who underwent bariatric surgery at 5 clinical centers in the United States were enrolled in the prospective, multicenter, long-term outcome study Teen–Longitudinal Assessment of Bariatric Surgery. Outcome data from younger (13–15 years; n = 66) and older (16–19 years; n = 162) study participants were compared. Outcomes included percent BMI change, comorbidity outcomes (hypertension, dyslipidemia, and type 2 diabetes mellitus), nutritional abnormalities, and quality of life over 5 years post surgery. RESULTS: Baseline characteristics, except for age, between the 2 cohorts were similar. No significant differences in frequency of remission of hypertension (P = .84) or dyslipidemia (P = .74) were observed between age groups. Remission of type 2 diabetes mellitus was high in both groups, although statistically higher in older adolescents (relative risk 0.86; P = .046). Weight loss and quality of life were similar in the 2 age groups. Younger adolescents were less likely to develop elevated transferrin (prevalence ratio 0.52; P = .048) and low vitamin D levels (prevalence ratio 0.8; P = .034). CONCLUSIONS: The differences in outcome of metabolic and bariatric surgery between younger and older adolescents were few. These data suggest that younger adolescents with severe obesity should not be denied consideration for surgical therapy on the basis of age alone and that providers should consider adolescents of all ages for surgical therapy for obesity when clinically indicated. ’ aChildren’s Hospital Colorado and School of Medicine, University of Colorado, Aurora, Colorado; bCincinnati WHAT S KNOWN ON THIS SUBJECT: Bariatric surgery is Children’s Hospital Medical Center, Cincinnati, Ohio; and cLucile Packard Children’s Hospital Stanford, Palo Alto, an effective, durable treatment of severe obesity in California adolescents, with results generally similar to or surpassing those for adults. However, little is known Dr Ogle conceptualized and designed the study, contributed to data interpretation, drafted the initial about the relative merits and risks of these procedures in manuscript, and critically reviewed the manuscript for important intellectual content; Dr Dewberry younger teenagers compared with older adolescents. conceptualized and designed the study and reviewed and revised the manuscript; Dr Jenkins designed the data collection instruments, collected data, conducted the analyses, contributed to WHAT THIS STUDY ADDS: We found that younger and data interpretation, and reviewed and revised the manuscript; Dr Inge conceptualized and designed older adolescents had similar weight loss, resolution of the study, contributed to data interpretation, obtained funding for the study, and critically reviewed hypertension and dyslipidemia, nutritional deficiencies, the manuscript for important intellectual content; Dr Kelsey contributed to data interpretation and and improvement in quality of life after surgery. Age alone critically reviewed the manuscript for important intellectual content; Dr Bruzoni conceptualized and should not dissuade providers and patients from designed the study, contributed to data interpretation, and reviewed and revised the manuscript; Dr pursuing surgery when medically indicated. Pratt conceptualized and designed the study, contributed to data interpretation, and critically reviewed the manuscript for important intellectual content; and all authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. To cite: Ogle SB, Dewberry LC, Jenkins TM, et al. Outcomes of Bariatric Surgery in Older Versus Younger Adolescents. Pediatrics. 2021;147(3):e2020024182 Downloaded from www.aappublications.org/news by guest on September 28, 2021 PEDIATRICS Volume 147, number 3, March 2021:e2020024182 ARTICLE Over recent decades, the global health postoperative instructions is a critical micronutrient status31 (ferritin, folate, and economic burden of obesity has barrier to treatment of severe obesity, vitamin B12, vitamin D, vitamin A, and continued to rise rapidly in both resulting in less than half of primary parathyroid hormone), and quality- developing and developed nations.1,2 care physicians considering referral of-life metrics (Impact of Weight on In the United States, obesity affects for pediatric patients.23,24 Data on Quality of Life [IWQOL] total score 13.7 million children, of whom 6% long-term outcomes after MBS in and 36-Item Short Form Health meet the definition of having severe younger adolescent or preadolescent Survey (SF-36) physical and mental obesity.3,4 Obesity has been linked to patients are limited, and outcomes in component scores) were evaluated. numerous complications involving the youngest children have only been Because of the small number of every body system.5,6 The rise of reported in case reports from outside participants who underwent – childhood obesity has brought an the United States.21,25 28 Comparative laparoscopic adjustable gastric emergence of chronic diseases once studies of adult and adolescent banding (n = 14), only those who only present in adulthood (eg, outcomes after MBS reveal similar underwent Roux-en-Y gastric bypass hypertension, dyslipidemia, and type weight loss and superior comorbidity (RYGB) (n = 161) or vertical sleeve 2 diabetes mellitus) and associated resolution in the adolescent gastrectomy (n = 67) were analyzed. with a decreased life expectancy of 5 population. To explore potential age- The clinical care of participants was to 20 years.7,8 Intensive medical and related differences in MBS outcomes at the discretion of the clinicians lifestyle interventions for the between older and younger at the centers where enrollment treatment of obesity have adolescents, we divided the occurred and was not dictated by demonstrated an average of 5% to Teen–Longitudinal Assessment of research protocol. Clinical care 15% weight loss, with variable results Bariatric Surgery (Teen-LABS) study – generally followed national guideline in sustainability.9 11 Alternatively, cohort into a younger and older group recommendations. Informed, written metabolic and bariatric surgery and compare weight loss, comorbidity consent was obtained from caregivers (MBS) has been shown to be an change, nutritional deficiencies, and and/or participants as appropriate effective and durable treatment for quality of life over 5 years.13,29 on the basis of age at the time of obesity and complications of obesity enrollment. Reconsenting was done in adolescents, with weight loss and METHODS when each participant reached the health improvements far surpassing age of 18. Study protocols, consents, those achieved with nonsurgical Teen-LABS is a multicenter – and data and safety monitoring were treatments.12 17 The most recent prospective observational study in approved by all institutional sites update of the pediatric American which 242 adolescents (#19 years of (Nationwide Children’s Hospital in Society for Metabolic and Bariatric age) were enrolled between 2007 and Columbus, OH; Cincinnati Children’s Surgery guidelines removed the 2011. Participants underwent MBS Hospital Medical Center in Cincinnati, recommendation of achieving adult between 2007 and 2012. Study OH; Texas Children’s Hospital in height or pubertal maturity before details, research methods, diagnostic Houston, TX; University of Pittsburgh pursuing MBS, thereby eliminating criteria, and data collection have Medical Center in Pittsburgh, PA; and younger age restrictions.12 previously been described and are Children’s of Alabama in Birmingham, available at ClinicalTrials.gov AL) and an independent data and In a recent policy statement, the (identifier NCT00474318).17,30 safety monitoring board before study American Academy of Pediatrics Baseline data were collected within initiation. Ongoing review of study advocates for increased use of and 30 days of MBS. Participants were performance and safety has been access to MBS for pediatric patients then evaluated at 6 months, 12 done by the data and safety and acknowledges insufficient months, and then annually, and monitoring board from 2007 to evidence to support age-based outcomes were evaluated up to present day. limitations for eligibility.18,19 5 years after surgery. During this time Evidence of the safety and frame, 230 of the 242 (95%) For this analysis, the Teen-LABS effectiveness of MBS in young participants remained as active study cohort was arbitrarily divided into adolescents and children is participants, completing 86% (1254 2 age groups: age 13 to 15 years increasing, but it is estimated that of 1452) of all postoperative research and age 16 to 19 years at the time ,1% of eligible pediatric patients visits. Baseline demographic, of surgery. Age group–specific undergo MBS for the treatment of anthropometric, and comorbidity categorical measures were presented – severe obesity.14,16 22 Hesitancy to data were obtained by trained study as frequencies and percentages refer due to concerns of safety, impact staff. Specifically, changes in 3 major
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