10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609

POT1 Polyclonal Antibody Catalog # AP72003

Specification

POT1 Polyclonal Antibody - Product Information

Application WB Primary Accession Q9NUX5 Reactivity Human, Monkey Host Rabbit Clonality Polyclonal

POT1 Polyclonal Antibody - Additional Information

Gene ID 25913

Other Names POT1; Protection of 1; hPot1; POT1-like end-binding protein

Dilution WB~~Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Format Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Conditions -20℃

POT1 Polyclonal Antibody - Protein Information

Name POT1

Function Component of the ribonucleoprotein (RNP) complex that is essential for the replication of termini. Is a component of the POT1 Polyclonal Antibody - Background double-stranded telomeric DNA-binding TRF1 complex which is involved in the Component of the telomerase regulation of telomere length by cis- ribonucleoprotein (RNP) complex that is inhibition of telomerase. Also acts as a essential for the replication of chromosome single-stranded telomeric DNA- binding termini. Is a component of the double-stranded protein and thus may act as a downstream telomeric DNA- binding TRF1 complex which is effector of the TRF1 complex and may involved in the regulation of telomere length transduce information about telomere

Page 1/2 10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609

maintenance and/or length to the telomere by cis-inhibition of telomerase. Also acts as a terminus. Component of the single-stranded telomeric DNA-binding protein complex (telosome) that is involved in the and thus may act as a downstream effector of regulation of telomere length and the TRF1 complex and may transduce protection. Shelterin associates with arrays information about telomere maintenance of double-stranded TTAGGG repeats added and/or length to the telomere terminus. by telomerase and protects chromosome Component of the shelterin complex ends; without its protective activity, (telosome) that is involved in the regulation of telomeres are no longer hidden from the telomere length and protection. Shelterin DNA damage surveillance and chromosome associates with arrays of double-stranded ends are inappropriately processed by DNA TTAGGG repeats added by telomerase and repair pathways. Binds to two or more protects chromosome ends; without its telomeric single-stranded 5'- TTAGGG-3' protective activity, telomeres are no longer repeats (G-strand) and with high specificity hidden from the DNA damage surveillance and to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds chromosome ends are inappropriately telomeric single-stranded sequences processed by DNA repair pathways. Binds to internally or at proximity of a 3'-end. Its two or more telomeric single-stranded activity is TERT dependent but it does not 5'-TTAGGG-3' repeats (G-strand) and with high increase TERT activity by itself. In contrast, specificity to a minimal telomeric the ACD-POT1 heterodimer enhances single-stranded 5'- TAGGGTTAG-3' sequence. telomere elongation by increasing Binds telomeric single-stranded sequences telomerase processivity. internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not Cellular Location increase TERT activity by itself. In contrast, the Nucleus. Chromosome, telomere. ACD-POT1 heterodimer enhances telomere Note=Colocalizes with telomeric DNA elongation by increasing telomerase processivity. Tissue Location Ubiquitous.

POT1 Polyclonal Antibody - Protocols

Provided below are standard protocols that you may find useful for product applications.

• Western Blot • Blocking Peptides • Dot Blot • Immunohistochemistry • Immunofluorescence • Immunoprecipitation • Flow Cytomety • Cell Culture

Page 2/2

Powered by TCPDF (www.tcpdf.org)