Mycobacterium Bovis BCG As a Delivery System for the Dtb Gene Antigen from Diphtheria Toxin
American Journal of Molecular Biology, 2017, 7, 176-189 http://www.scirp.org/journal/ajmb ISSN Online: 2161-6663 ISSN Print: 2161-6620 Mycobacterium bovis BCG as a Delivery System for the dtb Gene Antigen from Diphtheria Toxin Dilzamar V. Nascimento1,4, Odir A. Dellagostin2, Denise C. S. Matos3, Douglas McIntosh5, Raphael Hirata Jr.1, Geraldo M. B. Pereira1,4, Ana Luíza Mattos-Guaraldi1, Geraldo R. G. Armôa4* 1Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil 2Núcleo de Biotecnologia, Universidade Federal de Pelotas, Campus Universitário, Pelotas, Brazil 3Instituto de Tecnologia em Imunobiológicos, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil 4Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil 5Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropedica, Rio de Janeiro, Brazil How to cite this paper: Nascimento, D.V., Abstract Dellagostin, O.A., Matos, D.C.S., McIntosh, D., Hirata Jr., R., Pereira, G.M.B., Mat- Diphtheria is a fulminant bacterial disease caused by toxigenic strains of Co- tos-Guaraldi, A.L. and Armôa, G.R.G. rynebacterium diphtheriae whose local and systemic manifestations are due to (2017) Mycobacterium bovis BCG as a the action of the diphtheria toxin (DT). The vaccine which is used to prevent Delivery System for the dtb Gene Antigen from Diphtheria Toxin. American Journal diphtheria worldwide is a toxoid obtained by detoxifying DT. Although asso- of Molecular Biology, 7, 176-189. ciated with high efficacy in the prevention of disease, the current an- https://doi.org/10.4236/ajmb.2017.74014 ti-diphtheria vaccine, one of the components of DTP (diphtheria, tetanus and Received: April 17, 2017 pertussis triple vaccine), may present post vaccination effects such as toxicity Accepted: September 27, 2017 and reactogenicity resulting from the presence of contaminants in the vaccine Published: September 30, 2017 that originated during the process of production and/or detoxification.
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