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(ICPH-6) Buenos Aires, Argentina October 16-19, 2013 ICPH- 2013 I VIInternational Conference on Polyphenols and Health (ICPH-6) Buenos Aires, Argentina October 16-19, 2013 CONTENTS Previous ICPH Conferences Welcome I Organizing committees II Chair and co-chair Scientific secretary Local organizing and scientific committees International advisory board Congress secretariat Congress venue Oral and poster sessions III Program at a Glance IV Scientific Program V Abstracts Plenary lectures 1 Oral presentations 4 Poster presentations 33 Authors index 94 CONGRESS VENUE School of Law, University of Buenos Aires Av. Figueroa Alcorta 2263 Buenos Aires, Argentina Previous ICPH ICPH- 2013 Previous ICPHs Vichy, France, 2003 Davis, USA, 2005 Kyoto, Japan, 2007 Harrogate, UK, 2009 Barcelona, Spain, 2011 Welcome ICPH- 2013 Welcome Welcome to Buenos Aires and to the VI International Conference on Polyphenols and Health (ICPH-6). The series of biennial ICPHs started ten years ago in Vichy, France, and were always organized with the goal of maintaining the highest scientific level. In the path of this tradition, this year we present a program of exceptional quality, including speakers from all over the world, coming both from academia and also from the industry. The resulted program was built considering two enriching situations. First, the sessions were selected from an open call which allowed any interested person or group to propose subjects and speakers. As a result, we have a democratically selected compendium of sessions, covering themes of the most current interest delivered by outstanding scientists. Second, the activities shared with the VIII Society for Free Radical Biology and Medicine-South American Group, which is taking place in the same venue from October 14th to 17th. This overlapping is an opportunity to foster interactions among scientists interested in the health properties of plant polyphenols. As leaders of the organization we are very thankful to the financial contributions from several national and international public and private organizations, as well as from several companies that synergistically have made possible this ICPH-6. Finally, we really hope that everybody can profit from the science of this conference, and additionally take advantage of the cultural possibilities that Buenos Aires offers, under the beauties of a sunny and blooming October. Cesar G. Fraga Patricia I. Oteiza Chair Co-chair I Organizer and scientific committees ICPH- 2013 Organizing Committees CHAIR SCIENTIFIC SECRETARY Cesar G. Fraga, Argentina Monica Galleano, Argentina CO-CHAIR Patricia I. Oteiza, USA LOCAL ORGANIZING AND SCIENTIFIC COMMITTEES School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina Institute of Molecular Biochemistry and Medicine, UBA-CONICET, Buenos Aires, Argentina Silvia Alvarez Gabriela Malanga Silvina S. Bombicino Natacha Piloni Valeria Calabro Barbara Piotrkowski Analia Czerniczyniec Paula Prince Pablo A. Evelson Marisa Repetto Andrea Galatro Elizabeth Robello Paula M. Gonzalez Marcela Simontacchi Dario E. Iglesias Laura B. Valdez Analia Karadayian Virginia Vanasco Corina Litterio Sandra Verstraeten Silvia Lores Arnaiz Tamara Zaobornyj INTERNATIONAL ADVISORY BOARD Bharat Aggarwal, USA Christine Morand, France Cristina Andres-Lacueva, Spain Francisco Perez Vizcaino, Spain Brian Bandy, Canada Helmut Sies, Germany Aedin Cassidy, Norwich, UK Valerie Schini-Kerth, France Kevin Croft, Australia Jeremy P. E. Spencer, UK Alan Crozier, Scotland Young-Joon Surh, South Korea Daniele Del Rio, Italy Junji Terao, Japan AdrianFranke, USA Francisco Tomas-Barberan, Spain Balz Frei, USA Andrew Waterhouse, USA Peter Hollman, the Netherlands Gary Williamson, UK Paul Kroon, UK CONGRESS SECRETARIAT Gabriela Garavaglia Mariana Garces Nicolas Lopez Goldenberg II Oral and poster presentations ICPH- 2013 ORAL AND POSTER PRESENTATIONS ORAL SESSIONS 1 Metabolism of polyphenols in mammals 2 Metabolomics to assess dietary exposure and health effects of polyphenols 3 Molecular mechanisms of polyphenol actions 4 Polyphenols and cancer prevention 5 Polyphenols-gut interactions and health 6 Polyphenols and neurocognition 7 Polyphenols and cardiovascular health (I) 8 Polyphenols and long-term degenerative diseases 9 Polyphenols and cardiovascular health (II) 10 (Epi) genomic effects of polyphenols 11 Health effects of phenolic acids and resveratrol 12 ADME and health effects of isoflavones 13 ADME and health effects of anthocyanins 14 The road for evidence-based dietary recommendations for flavonoids: how do we get there? POSTER TOPICS 1 Methodology for polyphenols determination 1.1. Plants and foods 1.2. Animal tissues 1.3. Human samples 2 ADME 2.1. Absorption, tissue distribution and excretion 2.2. Metabolism 3 Mechanisms of action 3.1. Antioxidants and redox regulation 3.2. Receptor mediated 3.3. Protein and membrane interactions 4 Dietary intervention 4.1. Cancer 4.2. Cardiovascular 4.3. Metabolic disorders 4.4. Intestine and Microbiota 4.5. Brain/Neurobiology III Program at a Glance ICPH- 2013 PROGRAM AT A GLANCE Wednesday 16th Thursday 17th Friday 18th Saturday 19th 8:30-10:30 8:30-10:30 8:30-10:30 ROOM A ROOM B ROOM A ROOM B Session 1 Session 4 Session 5 Session 10 Session 11 Metabolism of Polyphenols Polyphenols-gut (Epi) genomic Health effects of polyphenols in and cancer interactions and effects of phenolic acids and mammals prevention health polyphenols resveratrol 10.30-11:00 Coffee Break 11:00-13:00 11:00-13:00 11:00-13:00 Session 2 ROOM A ROOM B ROOM A ROOM B Metabolomics to Session 6 Session 7 Session 12 Session 13 assess dietary Polyphenols Polyphenols and ADME and health ADME and health exposure and effects and cardiovascular effects of effects of of polyphenols neurocognition health (I) isoflavones anthocyanins 13:00-14:00 Lunch and posters viewing 13:00-14:00 Lunch 14:00-16:00 14:00-16:00 14:00-16:00 Session 3 ROOM A ROOM B Session 14 Molecular Session 8 Session 9 The road for evidence-based mechanisms of Polyphenols and Polyphenols and dietary recommendations for flavonoids: polyphenol actions long-term cardiovascular how do we get there? degenerative health (II) 14:00-18:00 diseases Registration 16:00-16:30 Closing Ceremony 16:00-16:30 Coffee Break Awards 16:30-17:30 16:30-17:30 Plenary Plenary Lecture 3 Lecture 4 17:30-19:00 17:30-19:00 Poster presentation Poster presentation 18:30-20:15 Session A Session B Plenary Lectures 1 & 2 20:15-21:00 Welcome reception IV Scientific Program ICPH- 2013 VI International Conference on Polyphenols and Health October 16-19, 2013 WEDNESDAY 16 14:00-18:00 Registration OPENING LECTURES Opening Lectures in the Honor of Federico Leighton at the School of Medicine, University of Buenos Aires, Buenos Aires, Argentina Sharing Activities with VIII SFRBM-SAG 18:30-18:45 Welcome address by Cesar G Fraga, University of Buenos Aires, Buenos Aires, Argentina. PLENARY LECTURE 1 Chair: Ricardo J Gelpi, University of Buenos Aires, Buenos Aires, Argentina. 18:45-19:30 Myocardial stretch induces reactive oxygen species production: its mechanical counterpart. Horacio Cingolani, University of La Plata, La Plata, Argentina. PLENARY LECTURE 2 Chair:Patricia Oteiza, University of California, Davis, USA. 19:30-20:15 Redox biology and dietary polyphenols. Helmut Sies, Heinrich-Heine University Dusseldorf, Dusseldorf, Germany. 20:15-21:00 WELCOME RECEPTION THURSDAY 17 SESSION 1 Metabolism of polyphenols in mammals Chairs: Francene M Steinberg, University of California, Davis, USA; Peter CH Hollman, Wageningen University and RIKILT, Wageningen, the Netherlands. 8:30-8:55 Absorption, metabolism and excretion of 14C-labelled (-)-epicatechin in humans. Alan Crozier, University of Glasgow, Glasgow, UK. 8:55-9:20 Studying the ADME of cocoa flavanols in humans: implications for future dietary intervention studies and investigations in vitro? Hagen Schroeter, MARS Inc., McLean, USA. 9:20-9:45 Metabolism has a high impact on the complex puzzle of the health effects of polyphenols. Peter CH Hollman, Wageningen University and RIKILT, Wageningen, the Netherlands. 9:45-10:10 Prenylation modulates the bioavailability of dietary flavonoids. Junji Terao, University of Tokushima, Tokushima, Japan. 10:10-10:20 Effects of green tea catechins with or without caffeine on fat oxidation at rest and during exercise. Silvina Lotito, Unilever R&D, Sharnbrook, UK. 10:20-10:30 Whole cell-dependent production of polyphenol conjugates using genetically engineered budding yeast Shinichi Ikushiro, Toyama Prefectural University, Toyama, Japan. 10:30-11:00 Coffee break V Scientific Program ICPH- 2013 SESSION 2 Metabolomics to assess dietary exposure and health effects of polyphenols Chairs:Claudine Manach, INRA, Clermont-Ferrand, France; Cristina Andres-Lacueva, University of Barcelona, Barcelona, Spain. 11:00-11:25 When metabolomics helps to elucidate the contribution of polyphenols in the health effects of plant foods. Claudine Manach, INRA, Clermont-Ferrand, France. 11:25-11:50 Non-targeted LC-MS metabolite profiling approach on human and animal studies to investigate the metabolic effect of whole grain rich diet. Kati Hanhineva, University of Eastern Finland, Kuopio, Finland. 11:50-12:15 In vitro and in vivo metabolic fate of black tea polyphenols. Doris Jacobs, Unilever R&D, Vlaardingen, the Netherlands. 12:15-12:40 Metabolomic strategies in clinical nutrition research: from polyphenol rich diet to revealing disease risk biomarkers. Cristina Andres-Lacueva, University of Barcelona, Barcelona, Spain. 12:40-12:50 Phase II metabolites of cyanidin-3-glucoside
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