DOCSLIB.ORG

Genome-Wide Analysis of the Parkinsonism-Dementia Complex

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Genome-Wide Analysis of the Parkinsonism-Dementia Complex ORIGINAL CONTRIBUTION Genome-Wide Analysis of the Parkinsonism- Dementia Complex of Guam Huw R. Morris, MB, PhD; John C. Steele, MD; Richard Crook, BSc; Fabienne Wavrant-De Vrièze, PhD; Luisa Onstead-Cardinale, BS; Katrina Gwinn-Hardy, MD; Nick W. Wood, MD, PhD; Matthew Farrer, PhD; Andrew J. Lees, MD; P. L. McGeer, MD, PhD; Teepu Siddique, MD, PhD; John Hardy, PhD; Jordi Perez-Tur, PhD Background: Parkinsonism-dementia complex (PDC) went conventional linkage analysis in 5 families with PDC. is a neurofibrillary tangle degeneration involving the depo- One marker, D20S103, generated a logarithm of odds score sition of Alzheimer-type tau, predominantly in the me- of greater than 1.5. Multipoint association analysis also sial temporal cortex, brainstem, and basal ganglia. It oc- highlighted 2 other areas on chromosome 14q (adjacent curs in focal geographic isolates, including Guam and the to D14S592, 59.2 megabases [M]) and chromosome 20 Kii peninsula of Japan. The familial clustering of the dis- (adjacent to D20S470, 17.4 M) with multipoint associa- ease has suggested that a genetic factor could be impor- tion logarithm of the odds scores of greater than 2. The tant in its etiology. areas around D20S103, D14S592, and D20S470 were fur- ther analyzed by association using additional microsat- Objective: To determine whether a genetic locus could ellite markers and by conventional linkage analysis. This be identified, linked, or associated with PDC. did not provide further evidence for the role of these areas in PDC. Design and Patients: We performed a genome-wide association study of 22 Guamanian PDC and 19 control Conclusions: This study has not identified a single subjects using 834 microsatellite markers with an ap- gene locus for PDC, confirming the impression of a geo- proximate genome-wide marker density of 4.4 centi- graphic disease isolate with a complex genetic, a genetic/ morgans. environmental etiology, or a purely environmental etiology. Results: Two-point association analysis identified 17 markers (PϽ.015). Each of these markers then under- Arch Neurol. 2004;61:1889-1897 FTER WORLD WAR II, US clarified by the identification of genetic military physicians as- mutations in affected autosomal domi- signed to Guam and Na- nant families.10 These genetic advances and tional Institutes of Health the continuing familial occurrence of PDC (NIH) scientists recog- on Guam led to the consideration of a ge- Anized that familial amyotrophic lateral scle- netic approach to this disease.11 A num- rosis (ALS) and atypical parkinsonism with ber of observations suggest that PDC may dementia (parkinsonism-dementia com- have a genetic etiology. The disease clus- plex [PDC]) were common among Cha- ters in some Guamanian Chamorro fami- morro living on Guam.1-4 These diseases lies but spares others.12-14 The disease has had been present on Guam for more than different prevalences in different vil- a century and were known as lytico, for pa- lages.15,16 The adjacent villages of Umatac ralysis, and bodig, for parkinsonism. It was and Merizo in southern Guam have simi- hoped that finding the cause of these dis- lar environments and their residents have eases would help to explain the causes of identical lifestyles, yet from 1956 to 1965, neurodegenerative diseases in the rest of the prevalence of PDC in Umatac was 274 the world. During the past 50 years, cy- per 100000 population and only 42 per cad neurotoxicity, infectious agents, and 100000 population in Merizo.15,17,18 Tra- calcium deficiency have been investi- ditionally, the populations of these vil- gated as possible causes for PDC but not lages did not intermarry. The disease may been proved to be relevant.5-9 occur in Chamorro migrants many years In recent years, the etiology of familial after they have left Guam.19-21 The dis- Author Affiliations are listed at Alzheimer disease, Parkinson disease, and ease often occurs in successive genera- the end of this article. frontotemporal dementia (FTD) has been tions and affects first-degree relatives. One (REPRINTED) ARCH NEUROL / VOL 61, DEC 2004 WWW.ARCHNEUROL.COM 1889 ©2004 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 Chamorro family in Umatac, southern Guam, is re- an immigrant population that now numbers 80000.30 Con- corded to have experienced the disease in every genera- temporary Chamorros are descended from a genetic tion since the late 1700s.2 Furthermore, a recent 40- “bottleneck” occurring 300 years (approximately 13 gen- year follow-up of a National Institutes of Health case- erations) ago, although a substantial part of the subse- control cohort shows that having an affected first- quent population growth relates to immigration. Ge- degree relative remains a risk factor for development of netic analysis of this disease assumes that a common PDC.22 Parkinsonism-dementia complex occurs in Gua- founder introduced a pathogenic mutation at an ances- manian Chamorros, but it does not seem to have af- trally distant point. The founder’s affected descendants fected the other ethnic groups who have immigrated to would share the pathogenic mutation and an adjacent Guam since World War II.23 Thus, among the many hun- chromosomal region. Genotyping of cases and control dreds of pathologically verified cases of this disease in subjects to determine shared alleles among cases should Chamorros during the past 50 years, there is only 1 clini- identify the area in which the pathogenic mutation lies. copathologic report of possible PDC in a Filipino mi- The strength of the association depends on the back- grant.24 In recent decades, the prevalence of PDC has ground frequency of the disease-associated allele in the steadily declined and the age at onset has increased.25-27 control population and decays with increasing distance This may support an exposure to a causal environmen- from the disease mutation, owing to meiotic recombi- tal factor with a cohort effect. Alternatively, this may re- nation. The background allele frequencies are un- flect increased social mobility and marrying out, thereby known a priori and may depend on whether the muta- allowing a decline in the co-occurrence of recessive ge- tion has arisen on an indigenous chromosome or has been netic factors, and/or a decrease in concurrence between introduced by an immigrant to the population. a genetic predisposition and environmental cofactors. A The evidence suggesting a genetic cause for PDC and previous report from our group has excluded the most the population structure of the affected Guamanian Cham- likely candidate gene for PDC, tau, by means of direct orro population led us to further investigate a genetic cause sequencing and microsatellite marker association.28 In the for PDC using an association analysis method. The over- present study, we have used linkage disequilibrium to lap between PDC and ALS is debated, but ALS has de- search for a PDC locus. clined in prevalence on Guam much more rapidly than Population-based disequilibrium studies involve map- PDC, such that there is only a handful of cases on the ping a disease locus by association at adjacent polymor- island at present, and ALS does not have a significantly phic genetic markers. They depend on a single gene mu- greater prevalence of disease on Guam than elsewhere. tation arising on a founder chromosome, accounting for Because of this, we decided to study PDC in isolation. a given disease in the population under study. This ap- We identified 22 apparently unrelated PDC cases and 19 proach has been used successfully in genetically iso- unrelated, neurologically asymptomatic controls for the lated populations, because they are more likely to have case-control study and selected 5 families for confirma- a single disease/single gene and mutation relationship (ge- tory linkage studies. Cases, controls, and family mem- netic and allelic homogeneity).29 They are also more likely bers underwent evaluation and selection by clinical neu- to have a sufficiently large shared chromosomal seg- rologists (J.C.S., H.R.M., K.G-H., and A.J.L.), and autopsy ment around any given marker and around a single dis- confirmation of PDC was subsequently obtained in 3 cases. ease gene mutation, depending on the age of the popu- lation and time of introduction of the mutation. An METHODS isolated population is defined as a population that is de- rived from a limited number of founder members and has expanded through growth rather than immigration. The CASE ASCERTAINMENT Chamorro population of Guam originated from a small number of immigrants from the Indo-Malay peninsula. All 22 cases were Chamorros with neurodegenerative symp- By the time of Magellan’s arrival in Guam in 1521, the toms beginning at ages that ranged from 54 to 74 years (de- population was 100000. However, with Spanish coloni- tailed demographic and clinical material on the 22 cases is avail- zation in the late 17th century, the native population was able from the authors on request). Eleven presented with dementia, and of these parkinsonism subsequently developed severely reduced to just 1608 by the early 1700s. The sur- in 10. Ten presented with parkinsonism, and of these demen- vivors, mostly women and children, were relocated to tia subsequently developed in 6. In the remaining case, demen- Catholic parishes on Guam, the largest and southern- tia (with paranoia) and parkinsonism occurred simulta- most island in the Mariana archipelago. Subsequently, neously. The parkinsonism usually had atypical features for the remaining Chamorro population mixed with Fili- Parkinson disease (ie, unresponsive to levodopa and involv- pino, Mexican, and Spanish immigrants who acted as ad- ing rigidity without rest tremor). In 10 of the 22 cases, fea- ministrators for the government of Guam and European tures of supranuclear gaze palsy, pseudobulbar palsy, and promi- sailors who visited the island during Pacific explora- nent axial rigidity were also seen.
Load more

Recommended publications
  • Rest Tremor Revisited: Parkinson's Disease and Other Disorders
    Chen et al. Translational Neurodegeneration (2017) 6:16 DOI 10.1186/s40035-017-0086-4 REVIEW Open Access Rest tremor revisited: Parkinson’s disease and other disorders Wei Chen1,2, Franziska Hopfner2, Jos Steffen Becktepe2 and Günther Deuschl1,2* Abstract Tremor is the most common movement disorder characterized by a rhythmical, involuntary oscillatory movement of a body part. Since distinct diseases can cause similar tremor manifestations and vice-versa,itischallengingtomakean accurate diagnosis. This applies particularly for tremor at rest. This entity was only rarely studied in the past, although a multitude of clinical studies on prevalence and clinical features of tremor in Parkinson’s disease (PD), essential tremor and dystonia, have been carried out. Monosymptomatic rest tremor has been further separated from tremor-dominated PD. Rest tremor is also found in dystonic tremor, essential tremor with a rest component, Holmes tremor and a few even rarer conditions. Dopamine transporter imaging and several electrophysiological methods provide additional clues for tremor differential diagnosis. New evidence from neuroimaging and electrophysiological studies has broadened our knowledge on the pathophysiology of Parkinsonian and non-Parkinsonian tremor. Large cohort studies are warranted in future to explore the nature course and biological basis of tremor in common tremor related disorders. Keywords: Tremor, Parkinson’s disease, Essential tremor, Dystonia, Pathophysiology Background and clinical correlates of tremor in common tremor re- Tremor is defined as a rhythmical, involuntary oscillatory lated disorders. Some practical clinical cues and ancillary movement of a body part [1]. Making an accurate diagnosis tests for clinical distinction are found [3]. Besides, accu- of tremor disorders is challenging, since similar clinical mulating structural and functional neuroimaging, as well entities may be caused by different diseases.
    [Show full text]
  • Neuroleptic Malignant-Like Syndrome
    An uncommon adverse effect of levodopa CASE REPORT withdrawal in a patient taking antipsychotic medication: neuroleptic malignant-like syndrome SP Man 文兆彪 A patient with symptoms suggestive of neuroleptic malignant syndrome after levodopa withdrawal is described. The patient presented with persistent high fever, stupor, autonomic dysfunction, rigidity, and rhabdomyolysis. He was successfully treated with intravenous dantrolene, resumption of levodopa, and forced alkaline diuresis. Doctors should be aware of the risk of abrupt cessation of dopamine agonists. Introduction Neuroleptic malignant syndrome (NMS) is an idiosyncratic, potentially fatal complication of treatment with antipsychotic drugs that manifests as fever, muscle rigidity, and autonomic and mental dysfunction.1 A similar clinical presentation has also been reported to develop after withdrawal from dopamine agonists.2,3 Some authors have used the terms neuroleptic malignant-like syndrome (NMLS) or parkinsonism hyperpyrexia syndrome, as well as acute akinesia or the malignant syndrome in Parkinson disease, for such a condition.4,5 The objective of this paper was to describe the first patient with NMLS in Hong Kong. Case report An 84-year-old Chinese man had chronic schizophrenia and was treated with chlorpromazine 50 mg at night for many years. Eighteen months prior to the index admission, chlorpromazine was replaced by olanzapine 20 mg daily as he had experienced extrapyramidal symptoms. He was also given levodopa 100 mg and benserazide 25 mg 3 times daily. He was admitted to Tuen Mun Hospital, Hong Kong, for a fever of 39.5ºC on 24 April 2010. He was conscious and did not have any specific symptoms. All medications, including olanzapine and levodopa, were stopped at admission as he was not permitted anything by mouth.
    [Show full text]
  • Multiple Developmental Forms of Parkinsonism. the Basis for Further Research As to the Pathogenesis of Parkinsonism
    J Neural Transm (2002) 109: 1469–1475 Mini-Review: Multiple developmental forms of parkinsonism. The basis for further research as to the pathogenesis of parkinsonism P. Riederer and P. Foley Clinical Neurochemistry, Clinic for Psychiatry and Psychotherapy and NPF-Center of Excellence Research Laboratories, University of Würzburg, Federal Republic of Germany Received September, 2002; accepted October 31, 2002 Summary. A range of extrapyramidal disturbances have been reported in children following early brain damage. In adults, damage to the basal ganglia can elicit abnormal motor activity in either direction; it would seem reason- able that the same would apply to damage occurring at an earlier develop- mental stage. The Viennese paediatrician Widhalm described a hypokinetic/ parkinsonoid syndrome (‘infantile hypokinetic-hypertonic syndrome with Parkinson symptomatic’) presented by a significant minority of the children with extrapyramidal movement disturbances, corresponding to the mild rigid- akinetic type of Parkinson’s disease. In contrast to classical parkinsonism, but consistent with some forms of post-encephalitic parkinsonism, the syndrome was reversible, although only after l-DOPA therapy. Widhalm’s observation that at least one form of childhood parkinsonism can be cured with l-DOPA also suggests that the amino acid plays a more active role than mere replace- ment therapy in children, perhaps also acting as a neurotrophic agent. It is proposed that environmental factors, including viral and risk factors associ- ated with pregnancy and birth, together with genetically determined lability, may increase the incidence of early hypokinesia/parkinsonism in particular and of Parkinson’s disease in later life by disturbing the immature basal ganglia at critical developmental stages.
    [Show full text]
  • Neurologic Disease Session Guidelines
    Neurologic Disease Session Guidelines This is a 15 minute webinar session for CNC physicians and staff CNC holds webinars monthly to address topics related to risk adjustment documentation and coding Next scheduled webinar: • June • Topic: Factors Influencing Health CNC does not accept responsibility or liability for any adverse outcome from this training for any reason including undetected inaccuracy, opinion, and analysis that might prove erroneous or amended, or the coder/physician’s misunderstanding or misapplication of topics. Application of the information in this training does not imply or guarantee claims payment. Agenda Neuropathy Parkinson's Disease Epilepsy Plegia/Paresis Other Neurologic Disease Key Documentation Elements Neuropathy The neuropathies listed below are associated with a HCC diagnosis: Inflammatory polyneuropathy Polyneuropathy that is due to alcohol, toxic agents, critical illness, radiation or drug induced Polyneuropathy in diseases classified elsewhere Document and code the other disease, such as amyloidosis, endocrine disease, metabolic disease, neoplasm, vitamin or nutritional deficiencies Neuropathy Risk Factors for development of Peripheral Neuropathy • Diabetes • Chemotherapy • HIV/AIDS • Autoimmune Disease • Chronic Inflammatory Demyelinating Polyneuropathy • Stress • Alcohol Abuse • Vitamin Deficiency • Genetic Diseases • Toxic Substances Parkinson’s Disease Parkinson’s disease is a HCC diagnosis, whether the condition is idiopathic, drug induced or a result of infectious or other external agents. Four Main Motor Symptoms 1. Shaking or tremor Parkinson's disease (PD) is a neurodegenerative brain disorder that 2. Slowness of movement, progresses slowly in most people. called bradykinesia 3. Stiffness or rigidity of the Parkinson's disease itself is not fatal. However, complications from arms, legs or trunk the disease are serious; the Centers for Disease Control and 4.
    [Show full text]
  • Parkinsonism: Onset, Progression, and Mortality
    Parkinsonism: onset, progression, and mortality Margaret M. Hoehn, M.D., and Melvin D. Yahr, M.D. PARKINSONISM,described in its entirety over lated to differences in terminology regarding one hundred and fifty years ago,’ rarely pre- the type of parkinsonism and the degree of its sents itself as a diagnostic problem. In conse- severity at the time of treatment. Consequent- quence, little scrutiny has been directed to the ly, it is difficult to determine whether treat- marked variability of this frequently encoun- ment really influences the course of the disease tered neurological syndrome and to the progres- and to what extent symptomatic relief is sig- sion of the disease in large groups of patients. nificant. It seems clear that, at a time when As with most chronic neurological disorders, many new approaches to the treatment of marked diversity can be expected to exist in parkinsonism are being suggested, information age and mode of onset, relative prominence of this sort is of paramount importance. of the cardinal signs and symptoms, rate of With this in mind, a study was made of 856 progression, and resultant degree of functional patients bearing the diagnosis of paralysis impairment. Controversy over the effectiveness agitans, Parkinson’s disease, or parkinsonism of therapeutic measures for parkinsonism is who were seen at the Vanderbilt Clinic of the due partially to this wide variability and to Columbia-Presbyterian Medical Center from the paucity of clinical information about the 1949 to 1964, inclusively. natural history of the
    [Show full text]
  • Movement Disorders Emergencies Part 1 Hypokinetic Disorders
    NEUROLOGICAL REVIEW SECTION EDITOR: DAVID E. PLEASURE, MD Movement Disorders Emergencies Part 1 Hypokinetic Disorders Bradley J. Robottom, MD; William J. Weiner, MD; Stewart A. Factor, DO ovement disorders usually do not require emergent intervention; nevertheless, there are acute/subacute clinical settings in which the neurologist is consulted. It is in these circumstances that the neurologist must be prepared to accurately diagnose and properly treat the patient. We have reviewed the literature regarding move- Mment disorder emergencies and divided them into hypokinetic (part 1) and hyperkinetic (part 2) presentations. In part 1, drug-induced syndromes including neuroleptic malignant syndrome, par- kinsonism hyperpyrexia syndrome, and serotonin syndrome will be discussed. Emergency com- plications related to the management of Parkinson disease, including falling, motor fluctuations, and psychiatric issues, will also be reviewed. Arch Neurol. 2011;68(5):567-572 Movement disorders often have an insidi- DRUG-INDUCED MOVEMENT ous onset and slow progression and are not DISORDER EMERGENCIES often associated with emergency situa- tions. However, neurologists may be called Neuroleptic Malignant Syndrome on to diagnose and treat evolving move- ment disorders or acute complications of Neuroleptic malignant syndrome, first de- existing diseases in the emergency depart- scribed in 1960,2 is an iatrogenic disorder re- ment or intensive care unit. Such situa- sulting from exposure to drugs that block tions meet the working definition of an dopamine
    [Show full text]
  • Drug-Induced Parkinsonism
    InformationInformation Sheet Sheet Drug-induced Parkinsonism Terms highlighted in bold italic are defined in increases with age, hypertension, diabetes, the glossary at the end of this information sheet. atrial fibrillation, smoking and high cholesterol), because of an increased risk of stroke and What is drug-induced parkinsonism? other cerebrovascular problems. It is unclear About 7% of people with parkinsonism whether there is an increased risk of stroke with have developed their symptoms following quetiapine and clozapine. See the Parkinson’s treatment with particular medications. This UK information sheet Hallucinations and form of parkinsonism is called ‘drug-induced Parkinson’s. parkinsonism’. While these drugs are used primarily as People with idiopathic Parkinson’s disease antipsychotic agents, it is important to note and other causes of parkinsonism may also that they can be used for other non-psychiatric develop worsening symptoms if treated with uses, such as control of nausea and vomiting. such medication inadvertently. For people with Parkinson’s, other anti-sickness drugs such as domperidone (Motilium) or What drugs cause drug-induced ondansetron (Zofran) would be preferable. parkinsonism? Any drug that blocks the action of dopamine As well as neuroleptics, some other drugs (referred to as a dopamine antagonist) is likely can cause drug-induced parkinsonism. to cause parkinsonism. Drugs used to treat These include some older drugs used to treat schizophrenia and other psychotic disorders high blood pressure such as methyldopa such as behaviour disturbances in people (Aldomet); medications for dizziness and with dementia (known as neuroleptic drugs) nausea such as prochlorperazine (Stemetil); are possibly the major cause of drug-induced and metoclopromide (Maxolon), which is parkinsonism worldwide.
    [Show full text]
  • Drug-Induced Parkinsonism
    REVIEW Print ISSN 1738-6586 / On-line ISSN 2005-5013 J Clin Neurol 2012;8:15-21 http://dx.doi.org/10.3988/jcn.2012.8.1.15 Open Access Drug-Induced Parkinsonism Hae-Won Shin,a Sun Ju Chungb aDepartment of Neurology, Chung-Ang University College of Medicine, Seoul, Korea bParkinson/Alzheimer Center, Department of Neurology, University of Ulsan College of Medicine, Seoul, Korea Drug-induced parkinsonism (DIP) is the second-most-common etiology of parkinsonism in the el- derly after Parkinson’s disease (PD). Many patients with DIP may be misdiagnosed with PD be- cause the clinical features of these two conditions are indistinguishable. Moreover, neurological deficits in patients with DIP may be severe enough to affect daily activities and may persist for long periods of time after the cessation of drug taking. In addition to typical antipsychotics, DIP may be caused by gastrointestinal prokinetics, calcium channel blockers, atypical antipsychotics, and anti- epileptic drugs. The clinical manifestations of DIP are classically described as bilateral and sym- metric parkinsonism without tremor at rest. However, about half of DIP patients show asymmetri- Received April 8, 2011 cal parkinsonism and tremor at rest, making it difficult to differentiate DIP from PD. The pathophy- Revised June 28, 2011 siology of DIP is related to drug-induced changes in the basal ganglia motor circuit secondary to Accepted June 28, 2011 dopaminergic receptor blockade. Since these effects are limited to postsynaptic dopaminergic re- Correspondence ceptors, it is expected that presynaptic dopaminergic neurons in the striatum will be intact. Dopa- Sun Ju Chung, MD, PhD mine transporter (DAT) imaging is useful for diagnosing presynaptic parkinsonism.
    [Show full text]
  • A Case of Drug-Induced Parkinsonism and Tardive Akathisia with E1143G POLG Mutation- Innocent Bystander Or a Culprit?
    Journal of Clinical and Translational Research 10.18053/Jctres/07.202103.001 CASE REPORT A case of drug-induced Parkinsonism and Tardive Akathisia with E1143G POLG mutation- Innocent bystander or a culprit? Pretty Sara Idiculla1*, Syed Taimour Hussain2, Junaid Habib Siddiqui1 1 University of Missouri Health Care, 1 Hospital Drive, Columbia, Missouri- 65212 2 United Medical and Dental College, Karachi, Pakistan *Corresponding Author Pretty Sara Idiculla University of Missouri Health Care, 1 Hospital Drive, Columbia, Missouri- 65212 202 Grasmere Drive, Staten Island, New York- 10305 Tel: +1 518-487-9071 e-mail: [email protected] Article information: Received: January 19, 2021 Revised: March 30, 2021 Accepted: March 30, 2021 Journal of Clinical and Translational Research 10.18053/Jctres/07.202103.001 Abstract Background and aim: Polymerase γ (POLG) is a protein that plays a pivotal role in the replication of the mitochondrial genome. POLG related disorders constitute a sequence of overlying phenotypes that can present from early infancy to late adulthood. Parkinsonism is the most common movement disorder associated with POLG mutation. We also summarize all reported cases of POLG related parkinsonism, along with a literature review. Case description: We present the case of an 80-year-old male presented with complaints of episodic confusion, tremors, and restlessness. He has been on risperidone for psychosis. A normal DaT scan ruled out Parkinson disease, and molecular analysis for POLG was positive (E1143G). He was diagnosed with drug-induced parkinsonism and tardive akathisia with an incidental POLG mutation. Conclusions: A literature search revealed 55 cases of ‘POLG related parkinsonism’ that met our criteria.
    [Show full text]
  • Parkinsonism Hyperpyrexia Syndrome Caused by Abrupt Withdrawal of Ropinirole
    Case RepoRt Parkinsonism hyperpyrexia syndrome caused by abrupt withdrawal of ropinirole Introduction worseningofparkinsonism.Highfeveris the impact that elevated serotonin levels Theparkinsonismhyperpyrexiasyndrome themostfrequentclinicalmanifestationof have on lowering dopamine levels. isararebutpotentiallyfatalcomplication parkinsonismhyperpyrexiasyndrome,fol- Serotonin syndrome may resolve quickly seeninpatientswithParkinson’sdisease.It lowedbyworseningofparkinsonismand butcanbepotentiallyfatal.Likeparkin- ischaracterizedbymentalstatuschanges, thenalteredlevelsofconsciousness. sonismhyperpyrexiasyndrome,therarity muscle rigidity, hyperthermia and auto- Levenson (1985) suggested a defini- and seriousness of serotonin syndrome nomicdysfunction.Mortalityofupto4% tionofneurolepticmalignantsyndrome precludes large randomized trials (Mills, hasbeenreportedbutanadditionalone- using the sum of three major or two 1997). thirdofpatientshavepermanentsequelae. major and four minor criteria in an Rapidly switching between dopamine Thetreatingphysicianshouldbemindful appropriateclinicalsetting(Table 1)and agonists may also lead to parkinsonism oftwoverysimilarandseriousconditions: thesecriteriacanalsobehelpfulindiag- hyperpyrexia syndrome as does dehydra- neurolepticmalignantsyndromeandsero- nosinganeurolepticmalignant-likesyn- tionandmetabolicdisturbances.Thedose toninsyndrome. drome condition, i.e. parkinsonism ofropinirolethatthispatientwasonpre- Parkinsonism hyperpyrexia syndrome hyperpyrexiasyndrome. eventwaslowandthepreparationalong- maybeindistinguishablefromneuroleptic
    [Show full text]
  • Types of Parkinsonism
    Information and support Types of parkinsonism arkinsonism is a term that covers several conditions, including PParkinson’s and other conditions with similar symptoms such as slow movement, rigidity (stiffness) and problems with walking. This information explains the different forms of parkinsonism and how parkinsonism is diagnosed. It also looks at how your specialist might work out which type of parkinsonism you have. What are the different forms of parkinsonism? Idiopathic Parkinson’s Most people with parkinsonism have idiopathic Parkinson’s disease, also known as Parkinson’s. Idiopathic means the cause is unknown. The most common symptoms of idiopathic Parkinson’s are tremor, rigidity and slowness of movement. Vascular parkinsonism Vascular parkinsonism (also known as arteriosclerotic parkinsonism) affects people with restricted blood supply to the brain. Sometimes people who have had a mild stroke may develop this form of parkinsonism. Common symptoms include problems with memory, sleep, mood and movement. Drug-induced parkinsonism Some drugs can cause parkinsonism. Neuroleptic drugs (used to treat schizophrenia and other psychotic disorders), which block the action of the chemical dopamine in the brain, are thought to be the biggest cause of drug-induced parkinsonism. The symptoms of drug-induced parkinsonism tend to stay the same – only in rare cases do they progress in the way that Parkinson’s symptoms do. Drug-induced parkinsonism only affects a small number of people, and most will recover within months – and often within days or weeks – of stopping the drug that’s causing it. Multiple system atrophy (MSA) Like Parkinson’s, MSA can cause stiffness and slowness of movement in the early stages.
    [Show full text]
  • Psychotropic Medications Induced Parkinsonism and Akathisia in People Attending Follow-Up Treatment at Jimma Medical Center, Psychiatry Clinic
    PLOS ONE RESEARCH ARTICLE Psychotropic medications induced parkinsonism and akathisia in people attending follow-up treatment at Jimma Medical Center, Psychiatry Clinic Assefa Kumsa, Liyew Agenagnew, Beza Alemu, Shimelis GirmaID* Department of Psychiatry, Institute of Health, Jimma University, Jimma, Ethiopia * [email protected] a1111111111 a1111111111 a1111111111 a1111111111 Abstract a1111111111 Objective To determine the magnitude and factors associated with psychotropic drug-induced parkin- sonism and akathisia among mentally ill patients. OPEN ACCESS Citation: Kumsa A, Agenagnew L, Alemu B, Girma Methods S (2020) Psychotropic medications induced A hospital-based cross-sectional study was conducted with a total of 410 participants parkinsonism and akathisia in people attending attending a follow-up treatment service at Jimma Medical Center, a psychiatry clinic from follow-up treatment at Jimma Medical Center, Psychiatry Clinic. PLoS ONE 15(7): e0235365. April to June 2019. Participants were recruited using a systematic random sampling method. https://doi.org/10.1371/journal.pone.0235365 Drug-induced parkinsonism and akathisia were assessed using the Extra-pyramidal Symp- Editor: Vincenzo De Luca, University of Toronto, tom Rating Scale. Substance use was assessed using the World Health Organization Alco- CANADA hol, Smoking, and Substance Involvement Screening Test. Data entry was done using Received: March 6, 2020 EpiData version 3.1, and analysis done by the Statistical Package for Social Sciences ver- sion 22. Statistically, the significant association was declared by adjusted odds ratio, 95% Accepted: June 13, 2020 confidence interval, and p-value less than or equal to 0.05. Published: July 2, 2020 Peer Review History: PLOS recognizes the Results benefits of transparency in the peer review process; therefore, we enable the publication of The mean age of the respondents was 33.3 years (SD ± 8.55).
    [Show full text]