Chemical Lecture Demonstrations: an Opportunity for Engagement Through Collections, Instruction, and Reference
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Historical Group
Historical Group NEWSLETTER and SUMMARY OF PAPERS No. 66 Summer 2014 Registered Charity No. 207890 COMMITTEE Chairman: Dr J A Hudson ! Dr C Ceci (RSC) Graythwaite, Loweswater, Cockermouth, ! Dr N G Coley (Open University) Cumbria, CA13 0SU ! Dr C J Cooksey (Watford, Hertfordshire) [e-mail [email protected]] ! Prof A T Dronsfield (Swanwick, Secretary: Prof. J. W. Nicholson ! Derbyshire) School of Sport, Health and Applied Science, ! Prof E Homburg (University of St Mary's University College, Waldegrave Road, ! Maastricht) Twickenham, Middlesex, TW1 4SX ! Prof F James (Royal Institution) [e-mail: [email protected]] ! Dr M Jewess (Harwell, Oxon) Membership Prof W P Griffith ! Dr D Leaback (Biolink Technology) Secretary: Department of Chemistry, Imperial College, ! Mr P N Reed (Steensbridge, London, SW7 2AZ [e-mail [email protected]] ! Herefordshire) Treasurer: Dr P J T Morris ! Dr V Quirke (Oxford Brookes University) Science Museum, Exhibition Road, South !Prof. H. Rzepa (Imperial College) Kensington, London, SW7 2DD ! Dr A Sella (University College) [e-mail: [email protected]] Newsletter Dr A Simmons Editor Epsom Lodge, La Grande Route de St Jean, St John, Jersey, JE3 4FL [e-mail [email protected]] Newsletter Dr G P Moss Production: School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS [e-mail [email protected]] http://www.chem.qmul.ac.uk/rschg/ http://www.rsc.org/membership/networking/interestgroups/historical/index.asp 1 RSC Historical Group Newsletter -
By Abraham Heifets a Thesis Submitted in Conformity with the Requirements
AUTOMATED SYNTHETIC FEASIBILITY ASSESSMENT:ADATA-DRIVEN DERIVATION OF COMPUTATIONAL TOOLS FOR MEDICINAL CHEMISTRY by Abraham Heifets A thesis submitted in conformity with the requirements for the degree of Doctor of Philosophy Graduate Department of Computer Science University of Toronto c Copyright 2014 by Abraham Heifets Abstract Automated Synthetic Feasibility Assessment: A Data-driven Derivation of Computational Tools for Medicinal Chemistry Abraham Heifets Doctor of Philosophy Graduate Department of Computer Science University of Toronto 2014 The planning of organic syntheses, a critical problem in chemistry, can be directly modeled as resource- constrained branching plans in a discrete, fully-observable state space. Despite this clear relationship, the full artillery of artificial intelligence has not been brought to bear on this problem due to its inherent complexity and multidisciplinary challenges. In this thesis, I describe a mapping between organic synthesis and heuristic search and build a planner that can solve such problems automatically at the undergraduate level. Along the way, I show the need for powerful heuristic search algorithms and build large databases of synthetic information, which I use to derive a qualitatively new kind of heuristic guidance. ii Contents Relation to published work xi 1 Introduction 1 2 Prolegomena to any future automated synthesis planning 6 2.1 Search . .6 2.2 AND/OR graph search algorithms . .9 2.2.1 AO* . 10 2.2.2 Learning in Depth-First Search (LDFS) . 12 2.2.3 The question of cycle semantics . 13 2.2.4 Proof Number Search (PNS) . 15 2.2.5 PN* . 19 2.2.6 Proof Disproof Search (PDS) . -
And Cambridge Chemist Computer
Summer 2011 Looking at solid –liquid interfaces Computer simulations of biologics War hero — and Cambridge chemist Chemistry’s new head of department As I see it... On 1 October, Daan Frenkel is taking over from Bill Jones as head of department. He talks to Sarah Houlton about how he perceives the future of Cambridge chemistry Perhaps you could start by telling us a dents, and we may need more partnerships with little about your own background. industry or private donors. As scientists, we like I’m now a theoretician, but I was trained as an to think our research is the most important experimentalist – my PhD was in experimental thing, but if you look at the people who come physical chemistry, and I really did get my out of the department and go on to key posi - hands dirty in the lab! But about 10 years after tions in society, my view is that our main prod - my PhD I switched to a focus on theoretical uct walks out of the department on two legs. work, although for the past 20 years I was We have been good at working in an interdis - working at the FOM Institute in Amsterdam, a ciplinary way, and this has to continue and research lab that was 80–90% experimental, so improve. Yet when we are competing for univer - I never lost contact with experiments. sity-wide projects such as doctoral training cen - tres, Cambridge has, in the past, been slower than Why did you accept the head of other institutions. To succeed we must strengthen department role here? our collaboration with other departments. -
Historical Group
Historical Group NEWSLETTER and SUMMARY OF PAPERS No. 66 Summer 2014 Registered Charity No. 207890 COMMITTEE Chairman: Dr J A Hudson ! Dr C Ceci (RSC) Graythwaite, Loweswater, Cockermouth, ! Dr N G Coley (Open University) Cumbria, CA13 0SU ! Dr C J Cooksey (Watford, Hertfordshire) [e-mail [email protected]] ! Prof A T Dronsfield (Swanwick, Secretary: Prof. J. W. Nicholson ! Derbyshire) School of Sport, Health and Applied Science, ! Prof E Homburg (University of St Mary's University College, Waldegrave Road, ! Maastricht) Twickenham, Middlesex, TW1 4SX ! Prof F James (Royal Institution) [e-mail: [email protected]] ! Dr M Jewess (Harwell, Oxon) Membership Prof W P Griffith ! Dr D Leaback (Biolink Technology) Secretary: Department of Chemistry, Imperial College, ! Mr P N Reed (Steensbridge, London, SW7 2AZ [e-mail [email protected]] ! Herefordshire) Treasurer: Dr P J T Morris ! Dr V Quirke (Oxford Brookes University) Science Museum, Exhibition Road, South !Prof. H. Rzepa (Imperial College) Kensington, London, SW7 2DD ! Dr A Sella (University College) [e-mail: [email protected]] Newsletter Dr A Simmons Editor Epsom Lodge, La Grande Route de St Jean, St John, Jersey, JE3 4FL [e-mail [email protected]] Newsletter Dr G P Moss Production: School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS [e-mail [email protected]] http://www.chem.qmul.ac.uk/rschg/ http://www.rsc.org/membership/networking/interestgroups/historical/index.asp 1 RSC Historical Group Newsletter -
Get Curious About
Year 12 Get Curious about... 1 CONTENTS Introduction 3 Art 4 Biology 5 Business Studies (A level and Btec) 6 Chemistry 7 Classical Civilisation 8 Computer Science 9 Drama 10 Economics 11 English Literature 12 English Language and Literature 13 Geography 14 HIstory 15 Mathematics and Further Mathematics 16 Music 17 Photography 18 Physical Education (A level and Btec) 19 Product Design 20 Physics 21 Politics 22 Psychology 23 Philosophy, Religion and Ethics (PRE) 24 Sociology 25 Spanish 26 2 Introduction Much of what I stumbled into, by following my curiosity and intuition, turned out to be priceless later on. Steve Jobs The joy of joining the sixth form is that you can really start to get curious about the subjects you have chosen; like Steve Jobs said, you never know how priceless the things you read, listen to and watch are going to be. This summer you have time to get curious about your A level / BTEC courses. We have produced this booklet to supplement the information provided to you via the induction booklet and resources on the Google Classroom/Google Drive. It also supports the Queens’ School Super-Curriculum, which you can find here. Every department has put together a small collection of resources that they would like you to try to read, listen to and watch before starting their course. You won’t be tested on these resources (they aren’t requirements for your course), but by getting curious about them you’ll start to understand where the sixth form might take you in the future, and how interesting your subjects are. -
Historical Group
Historical Group NEWSLETTER and SUMMARY OF PAPERS No. 77 Winter 2020 Registered Charity No. 207890 COMMITTEE Chairman: Dr Peter J T Morris ! Dr Christopher J Cooksey (Watford, 5 Helford Way, Upminster, Essex RM14 1RJ ! Hertfordshire) [e-mail: [email protected]] !Prof Alan T Dronsfield (Swanwick) Secretary: Prof. John W Nicholson ! Dr John A Hudson (Cockermouth) 52 Buckingham Road, Hampton, Middlesex, !Prof Frank James (University College) TW12 3JG [e-mail: [email protected]] !Dr Michael Jewess (Harwell, Oxon) Membership Prof Bill P Griffith ! Dr Fred Parrett (Bromley, London) Secretary: Department of Chemistry, Imperial College, ! Prof Henry Rzepa (Imperial College) London, SW7 2AZ [e-mail: [email protected]] Treasurer: Prof Richard Buscall, Exeter, Devon [e-mail: [email protected]] Newsletter Dr Anna Simmons Editor Epsom Lodge, La Grande Route de St Jean, St John, Jersey, JE3 4FL [e-mail: [email protected]] Newsletter Dr Gerry P Moss Production: School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS [e-mail: [email protected]] https://www.qmul.ac.uk/sbcs/rschg/ http://www.rsc.org/historical/ 1 RSC Historical Group Newsletter No. 77 Winter 2020 Contents From the Editor (Anna Simmons) 2 Letter from the Chair (Peter Morris) 3 ROYAL SOCIETY OF CHEMISTRY HISTORICAL GROUP MEETINGS 3 The Handed World: 150 Years of Chiral Molecules 3 ROYAL SOCIETY OF CHEMISTRY HISTORICAL GROUP NEWS (John Nicholson) 4 Follow-up from the Summer 2019 RSC Historical Group Newsletter -
Bang for the Buck How Chemistry Sparked the Birth of a Fireworks Business
RSC NEWS FEBRUARY 2013 www.rsc.org Bang for the buck How chemistry sparked the birth of a fireworks business FORGING SYNTHETIC LINKS WITH BIOLOGY AFRICA DEBATE p10 p12 The RSC supported 2012 Royal Institution Christmas Lectures were delivered by Peter Wothers, a lecturer at the University of Cambridge, who performed some of the most visually enticing and intellectually stimulating chemistry experiments. From the burning of phosphorus in air (below) to blowing up a Christmas tree made of gun cotton (top right) and messing with a million-volt Tesla coil that causes chemical reactions among the components of air (top left). All lectures are now available online at http://www.richannel.org/christmas-lectures READERSHIP SURVEY WEBSITE We would like to improve our communications Find all the latest news at with you. Help us by fi lling out our readership www.rsc.org/rscnews survey: http://rsc.li/rscnews-survey contents FEBRUARY 2013 Editor: Jon Edwards REGULARS Deputy Editor: Akshat Rathi 04 4 Snapshot Assistant Editors: Lynsey Thorpe, Chiara Ceci The latest news from the RSC Annika Schüller, Emma Stoye 6 Production: One to One Dale Dawson, Jenny Silventoinen What is CPD and why it is important for you Vivenne Brar Contact us: 7 Profile RSC News editorial office Romeela Mohee—environmental chemist Thomas Graham House Science Park, Milton Road and engineer Cambridge, CB4 0WF, UK 14 07 Tel: +44 (0)1223 432460 Editorial Email: [email protected] Editor’s note and letters on RSC activities Burlington House, Piccadilly and issues London W1J 0BA, UK Tel: -
Download Chem@Cam 59 Here
Chemistry at Cambridge Magazine SPRING 2019 ISSUE 59 Chemistry opens its doors chem@cam Sparks fly at Open Day A Wider Approach to Alzheimer’s Alumni Celebrate Women in Chemistry www.ch.cam.ac.uk Contents WOMEN IN CHEMISTRY BOOKS Testing the air 18 Revising a classic 20 PEOPLE RESEARCH Chemistry’s coxswain Fuel from plastic Image: courtesy of AllMarkOne 22 24 From the Head of Department 3 Women in Chemistry: Anika Krause 18 Sparks fly at Open Day 4 Classic textbook gets a makeover 20 Table Talk: A Periodic Alumni Reunion 6 “Outside the lab, I cox the Cambridge Boat Race crew.” 22 News 8 Fuel from Plastic: Taylor Uekert 24 News 10 Turning towards the Sun 26 Correspondence 1 1 Inspired by their mentor 28 A Wider Approach to Alzheimer’s 12 Staying in touch 30 Alumni Celebrate Women in Chemistry 14 How You Can Contribute 31 Coming full circle: Professor Chris Hunter 16 Save the Date: Alumni Wine Tasting 32 Welcome have had several opportunities in the last few months to welcome groups of Chemistry alumni back to the department. It has been I wonderful to meet old friends, to hear their memories of life in the lab and to find out about what they are doing now. Our annual alumni reunion in March was centred around the celebrations of the 150th anniversary of the Periodic Table. (See the feature on pages 6-7). My colleague Peter Wothers gave a splendid talk shedding light on how the Periodic Table evolved into its Cover photograph taken at Chemistry Open Day by Gaby Bocchetti. -
Celebrating a Year of International Chemistry
Celebrating a year of international chemistry The International Year of Chemistry... ...brought people together from all over the world to share an appreciation of chemistry and its importance to society. Launched in January 2011 by the International Union of Pure and Applied Chemistry (IUPAC), and the United Nations Educational, Scientific, and Cultural Organization (UNESCO), IYC recognised the global significance of chemistry. It also marked 100 years since the International Association of Chemical Societies was founded, and 100 years since Marie Curie was awarded the Nobel Prize for Chemistry. In this special publication, we’ve captured for prosperity some of the activities that the RSC and its members have organised and taken part in throughout 2011. www.rsc.org JANUARY The Rt Hon David Willetts MP, Cabinet Minister for Universities and Science, officially launches IYC at the Palace of Westminster. He’s joined by co-hosts Mark Lancaster TD MP, Andrew Miller MP and Julian Huppert MP. Guests are treated to some ‘explosive’ chemistry demonstrations by Hal Sosabowski from the University of Brighton. Members watch the event online via a live webcast. Women scientists from at least 42 countries gather together via video link and social media channels to share a chemical moment in time over breakfast. At the Chemistry Centre, RSC members watch video interviews recorded just a few hours earlier by their counterparts enjoying breakfasts in Beijing and India, and then record their own views to share. RSC members across the UK hold their own breakfast meetings. The European Association for Chemical and Molecular Sciences marks IYC with a new book celebrating the achievements of women in chemistry, from early pioneers to present day chemists. -
Chemistry Olympiad in Cambridge Protein Folding
Summer 2009 Chemistry Olympiad in Cambridge The automation of chemical reactions Protein folding – and misfolding Enthusing the chemists of tomorrow As I see it... What do you hope the centre will achieve? Cambridge alumnus Kelly Chibale is setting up a drug discovery The idea is to generate know-how and skills in ADME within South Africa for the first time. centre at the University of Cape Town. He tells Sarah Houlton more These are things that are well established and precedented elsewhere, but have never been How did you end up in Cape Town? trouble getting funding. There, I felt I would be a done in South Africa on this scale before. We can I’m originally from Zambia, and studied chem - very small fish in a very big pond, and my learn from the experiences and failures of those istry there before going to work for a company impact would be negligible, but if I came to Cape who have already embraced ADME principles, specialising in making explosives for the mining Town I would be able to make a much bigger and benefit from being able to find out what is industry. I was doing everything from nitrating impact. And now I’m setting up a drug discovery happening to the compound. glycerine to its formulation as dynamite powder centre at the university that hopefully will con - The aim is to be able to deliver quality pre- and the waterproof gelignite forms, and I was tribute to Africa discovering its own drugs. clinical drug candidates that will be developed in even assembling detonators! I was fortunate then partnership with pharmaceutical companies.