Table 7.1 Leading Cancer in Wang Chan District, Rayong (Male) 52 (Mean Annual ASR 2013 - 2015)

Cancer Incidence in Rayong, Thailand, 2013-2015

FOREWORD

The cancer registry plays a pivotal role in the overall program for cancer control. Statistical information produced from this registry may be used in numerous disciplines of clinical and public health, while the cancer data collected becomes increasingly valuable if comparability over time is maintained. A cancer registry must provide accurate, comprehensive, and timely information, where the elements of quality hinge on five main areas of concern. These are completeness of coverage, completeness of detail, accuracy of detail, accuracy of reporting, and accuracy of interpretation.

This is the statistical report of the Rayong population-based cancer registration from 2013 to 2015, representing the cancer incidence that may reflect the true cancer burden for the province.

As time preceded this population-based registry continuously attains maturity, thus providing more accurate information. While the 3 years cancer report of the Rayong Cancer Registry offers the commonly accepted format presentation of international cancer statistics, it also attempts to strictly fulfill the requirements contained in the guidelines for reporting of cancer incidence set by the International Agency for Research on Cancer (IARC), to make it comparable with other similar publications.

Consistent with the intensification efforts initiated by the Cancer Registry Unit team, Chonburi Cancer Hospital, to improve the quality and quantity of cancer documentation in every effort was made to strengthen the registry. Additional resources and manpower were put in place to ensure the verification procedure for the increased volume of relevant cancer records and to facilitate the active case finding as an effort to ensure the completeness of the information.

Last but not least, I wish to extend compliments to the authors and the team members of the Registry for all their contributions. I am confident that the 3-year report of the Rayong Cancer Registry would provide valuable information on cancer incidence and would spur the right impetus for unrelenting efforts in cancer control specifically in the eastern part of Thailand and generally for the whole country.

Akarathan Jitnuyanont, M.D. Director of Chonburi Cancer Hospital Ministry of Public Health Chonburi, Thailand, 20000

A Cancer Incidence in Rayong, Thailand, 2013-2015

ACKNOWLEDGEMENTS

Cancer Registry Unit, Chonburi Cancer Hospital wish to express our gratitude to individuals and organizations for this contribution to the Rayong Cancer Registry, including all staff members of the medical and health profession in Rayong, The Nation Cancer Institute for the cancer notifications, Provincial Public Health Service of Rayong for generous assistance, The National Health Security Office for information technology of cancer cases, Bureau of Policy and Strategy, Ministry of Public Health for mortality lists and Department of Statistics for population statistics.

It is our privilege to thank Thaniskarrn Srikaew and all staff members of community hospitals for the cancer cases data.

We are extremely thankful to Dr. Sukit Bandchongkit, Chanthip Intawong, Laphatrada Sadokbua, and your team for their kind help and co-operation throughout this project.

Thank you all for the valuable contributions.

Akarathan Jitnuyanont, M.D. Director of Chonburi Cancer Center Department of Medical Services Ministry of Public Health

Sirentra Wanglikitkoon, M.D. Chief, Digital Medical Division

B Cancer Incidence in Rayong, Thailand, 2013-2015

CONTENTS

Page

Foreword A Acknowledgements B Collaborators J Introduction 1 Methods 4 Result of all cancer 9 Pathology 17 Mueang Rayong District 36 Ban Chang District 41 Klaeng 46 Wang Chan 51 Ban Khai 56 Pluak Daeng 61 Khao Chamao 66 Nikhom Patthana 71 The incidence of common cancer 76 References 85

C ancer Incidence in Rayong, Thailand, 2013-2015 LIST OF TABLES Page

Table 1 Land area and an estimated population of the Eastern 2 part of Thailand in 2014 (average 2013 - 2015) Table 2.1 Rayong (2014), Mean annual ASR per 100,000 13 (2013 – 2015) by Age Group - Male Table 2.2 Rayong (2014), Mean annual ASR per 100,000 14 (2013 – 2015) by Age Group - Female Table 2.3 Mean annual incidence, Rayong, 2013 - 2015 15 Table 2.4 Percentage of morphologically verified and death 16 certificate only cases, Rayong Table 2.5 Pathology according to sites and sexes of all cancers 17

Table 3.1 Rayong (2014), Mean annual ASR per 100,000 (2013 – 2015) 34 by District – Male Table 3.2 Rayong (2014), Mean annual ASR per 100,000 (2013 – 2015) 35 by District – Female Table 4.1 Leading cancer in Muang Rayong District, Rayong (Male) 37 (mean annual ASR 2013 - 2015) Table 4.2 Leading cancer in Muang Rayong District, Rayong (Female) 37 (mean annual ASR 2013 - 2015)

Table 4.3 Muang Rayong (2014), Mean annual ASR per 100,000 39 (2013 – 2015) by Age Group - Male Table 4.4 Muang Rayong (2014), Mean annual ASR per 100,000 40 (2013 – 2015) by Age Group - Female Table 5.1 Leading cancer in Ban Chang District, Rayong (Male) 42 (mean annual ASR 2013 - 2015) Table 5.2 Leading cancer in Ban Chang District, Rayong (Female) 42 (mean annual ASR 2013 - 2015)

Table 5.3 Ban Chang (2014), Mean annual ASR per 100,000 44 (2013 – 2015) by Age Group - Male

Cancer Incidence in Rayong, Thailand, 2013-2015

LIST OF TABLES Page Table 5.4 Ban Chang (2014), Mean annual ASR per 100,000 45 (2013 – 2015) by Age Group - Female Table 6.1 Leading cancer in Klaeng District, Rayong (Male) 47 (mean annual ASR 2013 - 2015)

Table 6.2 Leading cancer in Klaeng District, Rayong (Female) 47 (mean annual ASR 2013 - 2015)

Table 6.3 Klaeng (2014), Mean annual ASR per 100,000 49 (2013 – 2015) by Age Group - Male Table 6.4 Klaeng (2014), Mean annual ASR per 100,000 50 (2013 – 2015) by Age Group - Female Table 7.1 Leading cancer in Wang Chan District, Rayong (Male) 52 (mean annual ASR 2013 - 2015)

Table 7.2 Leading cancer in Wang Chan District, Rayong (Female) 52 (mean annual ASR 2013 - 2015)

Table 7.3 Wang Chan (2014), Mean annual ASR per 100,000 54 (2013 – 2015) by Age Group - Male Table 7.4 Wang Chan (2014), Mean annual ASR per 100,000 55 (2013 – 2015) by Age Group - Female Table 8.1 Leading cancer in Ban Khai District, Rayong (Male) 57 (mean annual ASR 2013 - 2015)

Table 8.2 Leading cancer in Ban Khai District, Rayong (Female) 57 (mean annual ASR 2013 - 2015)

Table 8.3 Ban Khai (2014), Mean annual ASR per 100,000 59 (2013 – 2015) by Age Group - Male Table 8.4 Ban Khai (2014), Mean annual ASR per 100,000 60 (2013 – 2015) by Age Group - Female

C ancer Incidence in Rayong, Thailand, 2013-2015

LIST OF TABLES Page Table 9.1 Leading cancer in Pluak Daeng District, Rayong (Male) 62 (mean annual ASR 2013 - 2015) Table 9.2 Leading cancer in Pluak Daeng District, Rayong (Female) 62 (mean annual ASR 2013 - 2015)

Table 9.3 Pluak Daeng (2014), Mean annual ASR per 100,000 64 (2013 – 2015) by Age Group - Male Table 9.4 Pluak Daeng (2014), Mean annual ASR per 100,000 65 (2013 – 2015) by Age Group - Female Table 10.1 Leading cancer in Khao Chamao District, Rayong (Male) 67 (mean annual ASR 2013 - 2015)

Table 10.2 Leading cancer in Khao Chamao District, Rayong (Female) 67 (mean annual ASR 2013 - 2015)

Table 10.3 Khao Chamao (2014), Mean annual ASR per 100,000 69 (2013 – 2015) by Age Group - Male Table 10.4 Khao Chamao (2014), Mean annual ASR per 100,000 70 (2013 – 2015) by Age Group - Female Table 11.1 Leading cancer in Nikhom Patthana District, Rayong (Male) 72 (mean annual ASR 2013 - 2015)

Table 11.2 Leading cancer in Nikhom Patthana District, Rayong (Female) 72 (mean annual ASR 2013 - 2015)

Table 11.3 Nikhom Patthana (2014), Mean annual ASR per 100,000 74 (2013 – 2015) by Age Group - Male Table 11.4 Nikhom Patthana (2014), Mean annual ASR per 100,000 75 (2013 – 2015) by Age Group - Female Table 12.1 Lung cancer incidence, Mean annual ASR per 100,000 77 (2013 – 2015) by District – Male

Cancer Incidence in Rayong, Thailand, 2013-2015

LIST OF TABLES Page Table 12.2 Lung cancer incidence, Mean annual ASR per 100,000 78 (2013 – 2015) by District – Female Table 13.1 Liver cancer incidence, Mean annual ASR per 100,000 79 (2013 – 2015) by District – Male Table 13.2 Liver cancer incidence, Mean annual ASR per 100,000 80 (2013 – 2015) by District – Female Table 14.1 Colorectal cancer incidence, Mean annual ASR per 100,000 81 (2013 – 2015) by District – Male Table 14.2 Colorectal cancer incidence, Mean annual ASR per 100,000 82 (2013 – 2015) by District – Female Table 15 Breast cancer incidence, Mean annual ASR per 100,000 83 (2013 – 2015) by District – Female Table 16 Cervical cancer incidence, Mean annual ASR per 100,000 84 (2013 – 2015) by District – Female

C ancer Incidence in Rayong, Thailand, 2013-2015

LIST OF FIGURES

Page Figure 1.1 Map of the eastern region, Thailand 3 Figure 1.2 Estimated population densities by districts, Rayong 3 (2013 - 2015) Figure 2.1 Population pyramid in Rayong province estimated population 10 in 2014 (average 2013 - 2015) Figure 2.2 Age-specific incidence rates of all in Rayong, 10 mean annual rate per 100,000 (2013 - 2015)

Figure 2.3 Leading cancer in Rayong (mean annual ASR 2013 - 2015) 11 Figure 2.4 Stage of all cancer in Rayong (mean annual ASR 2013 - 2015) 12 Figure 3.1 Mean annual incidence in Rayong (2013 – 2015), Male 34 Figure 3.2 Mean annual incidence in Rayong (2013 – 2015), Female 35 Figure 4.1 Population pyramid in Muang Rayong District, Rayong 36 estimated population in 2014 (average 2013 - 2015) Figure 4.2 Leading cancer in Muang Rayong District, Rayong 38 (mean annual ASR 2013 - 2015) Figure 5.1 Population pyramid in Ban Chang District, Rayong 41 estimated population in 2014 (average 2013 - 2015) Figure 5.2 Leading cancer in Ban Chang District, Rayong 43 (mean annual ASR 2013 - 2015) Figure 6.1 Population pyramid in Klaeng District, Rayong 46 estimated population in 2014 (average 2013 - 2015) Figure 6.2 Leading cancer in Klaeng District, Rayong 48 (mean annual ASR 2013 - 2015) Figure 7.1 Population pyramid in Wang Chan District, Rayong 51 estimated population in 2014 (average 2013 - 2015) Figure 7.2 Leading cancer in Wang Chan District, Rayong 53 (mean annual ASR 2013 - 2015) Figure 8.1 Population pyramid in Ban Khai District, Rayong 56 estimated population in 2014 (average 2013 - 2015) HD

Cancer Incidence in Rayong, Thailand, 2013-2015 LIST OF FIGURES Page Figure 8.2 Leading cancer in Ban Khai District, Rayong 58 (mean annual ASR 2013 - 2015) Figure 9.1 Population pyramid in Pluak Daeng district, Rayong 61 estimated population in 2014 (average 2013 - 2015) Figure 9.2 Leading cancer in Pluak Daeng District, Rayong 63 (mean annual ASR 2013 - 2015) Figure 10.1 Population pyramid in Khao Chamao district, Rayong 66 estimated population in 2014 (average 2013 - 2015) Figure 10.2 Leading cancer in Khao Chamao District, Rayong 68 (mean annual ASR 2013 - 2015) Figure 11.1 Population pyramid in Nikhom Patthana district, Rayong 71 estimated population in 2014 (average 2013 - 2015) Figure 11.2 Leading cancer in Nikhom Patthana District, Rayong 73 (mean annual ASR 2013 - 2015) Figure 12.1 Mean annual Lung cancer incidence in Rayong 77 (2013 – 2015), Male Figure 12.2 Mean annual Lung cancer incidence in Rayong 78 (2013 – 2015), Female Figure 13.1 Mean annual Liver cancer incidence in Rayong 79 (2013 – 2015), Male Figure 13.2 Mean annual Liver cancer incidence in Rayong 80 (2013 – 2015), Female Figure 14.1 Mean annual Colorectal cancer incidence in Rayong 81 (2013 – 2015), Male Figure 14.2 Mean annual Colorectal cancer incidence in Rayong 82 (2013 – 2015), Female Figure 15 Mean annual Breast cancer incidence in Rayong 83 (2013 – 2015), female Figure 16 Mean annual Cervical cancer incidence in Rayong (2013 – 2015), female 84

C ancer Incidence in Rayong, Thailand, 2013-2015

COLLABORATORS 1. Chonburi Cancer Hospital: 300 Moo 2 Samed, Muang, Chonburi 20000 Akarathan Jitnuyanont, M.D. Director Jitraporn Tanabodee, M.D. Consultant Laddawal Vonk, R.N. Consultant Pranee Praphan, R.N. Consultant Jintana Phanpoowonng, R.N. Consultant

Secretarial staff: Sirentra Wanglikitkoon, M.D. Chief, Digital Medical Division Thitaree Kulanan, R.N. Cherleomrit Prapapkam Medical Statistics Technician Wanlapa Khasan, R.N. Chutima Phrmtu Medical Statistics Technician Watcharaporn Aromsawa General Administration Officer Papanin Thisena Academic computing Sasinan Krachun Administrative officer Kamonchanok Sarakorn Administrative officer

2. National Cancer Institute Rama VI Road, Ratchathewi District, Bangkok, 10400 Tel. 02 202 6800 Jinda Rojanamatin, M.D. Director InstituteSuleeporn Sangrajrang, Ph.D Deputy Director Rangsiya Buasom, R.N. Nisit Singhakosit Siriphon Sitthikong Phanit Raktapongpaisal Maliwan Saroj Netnapa Anantasing Sutthida Thungkeaw JD Cancer Incidence in Rayong, Thailand, 2013-2015

3. Provincial Public Health Service of Rayong Sukhumvit Rd, Muang, Rayong 21000 Tel. (038) 967415-7 Fax. (038) 611336 Sunthorn Rheanpumikankit, M.D. Rayong Provincial chief of Medical Office Laphatrada Sadokbua, Ph.D

4. Rayong Hospital 138 Sukhumvit Rd, Tha Pradu, Muang, Rayong 21000 Tel. (038) 611104 Chaiyasit Thepchatri, M.D. Director Thaniskarrn Srikaew, R.N.

5. Klaeng Hospital 254 Thang Kwian, Klaeng, Rayong 21110 Tel. (038) 677537 Pusit subsopon, M.D. Director Mailatree wongwaiwiriya, R.N.

6. Ban Khai Hospital 144 Moo 4 Hnonglalok, Bankhai, Rayong 21120 Tel. (038) 641005 Prasit Thongsadayu, M.D. Director Nungrutai Ditjarean, R.N.

7. Ban Chang Hospital 77 Moo 1 Pla, Ban Chang, Rayong 21130 Tel. (038) 603838 Kitchai Pattarakulpong, M.D. Director Waree sribut, R.N.

K Cancer Incidence in Rayong, Thailand, 2013-2015 8. Pluak Daeng Hospital 272 Moo 1 Pluak Daeng, Rayong 21140 Tel. (038) 659117 ext. 231 Tasanathep Yimyam, M.D. Director Sirikorn Khunhiran, R.N.

9. Wang Chan Hospital 349 Chum Sang, Wang Chan, Rayong 21210 Tel. (038) 666174 Pradit Pathawesrisutha, M.D. Director Saibua Panchana, R.N.

10. Khao Chamao Hospital 102/9 Moo 2 Huai Thap Mon, Khao Chamao, Rayong 21110 Tel. (038) 996022-3 Kitima Setboonsrang, M.D. Director Benchawan Boonploy, R.N.

11. Nikhom Phatthana Hospital 17 Moo 2 Phana Nikhom, Nikhom Phatthana, Rayong 21180 Tel. (038) 038050-5 Komon Phoothavonsub, M.D. Director Jiradchaya Lobpairin, R.N. Naruemon Sungsuwan

12. Memorial Hospital Sirindhorn 111 Sukhumvit Rd, Huay Pong, Muang, Rayong 21150 Tel. (038) 6844444 Suratin Maleehuan, M.D. Director Phachsitha Taithammasamit, R.N.

L Introduction Cancer Incidence in Rayong, Thailand, 2013-2015

Introduction Overview This monograph is published by the Chonburi Cancer Hospital in collaboration with the Rayong provincial hospital, the Rayong Provincial Public Health Service, all community hospitals and the National Cancer Institute. This report aims to present the data on cancer incidence in the Rayong province including in 8 districts and during the period 2013-2015. To provide comparable rates of the incidence of cancer from different areas in Rayong and Thailand during the same period. This monograph is also be used by educators, the media and members of the public with an interest in cancer. In this monograph we present incidence rates according to cancer sites classified by the International Classification of Diseases for Oncology (ICD-O), The Third Edition (Fritz et al., 2000) World Health Organization Geneva. The Chonburi Cancer Hospital, one of the seven regional cancer centers, was established in 1994 under supervision of the National Cancer Institute for cancer prevention and control in the Eastern part of Thailand as a result the population-based cancer registration in the province has been set up. The National Cancer Institute and all regional cancer centers have a role in all main activities of cancer prevention and control, including prevention, screening, and tertiary care as well as having clinical research activity. The Chonburi Cancer Hospital has provided programs inpatient and public education and continuing education for health professionals, particularly family physicians and general nurses especially in the eastern part of Thailand. This covers only 8 provinces: Chonburi, Rayong, Chanthaburi, Trat, Chachoengsao, Srakaeo, Prachinburi, and Samut Prakan which is shown in Figure 1.1.

Background, Geographic Situation of Rayong Rayong is one of the eight provinces in the Eastern part of Thailand situated between 12o-13o N and 101o-102o E, 179 kilometers from Bangkok by car or bus, with a land area of 3552 square kilometers, 5 meters above sea level, and is bounded on the North, and the West by Chonburi, on the East by Chanthaburi and gulf of Thailand to the South.

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Introduction Cancer Incidence in Rayong, Thailand, 2013-2015

The province is comprised out of coastal plains, slope and hilly land, mountains and two major rivers which flow to the sea. The climate is rather warm, the highest temperature in the summer (March to May) is about 38.7 oC, 17.8 oC. In the winter (November to February) the temperature is about 17.8 oC. The rainy season starts in May and is until October. Rayong is divided into 8 districts, 58 communes (Tambon) and 439 villages. The districts of Rayong are Muang Rayong, Klaeng, Ban Chang, Wang Chan, Ban Khai, Pluak Daeng, Khao Chamao and Nikhom Phatthana.

Population of Rayong The average population in 2013-2015 was 821,133 with 413,300 males and 407,833 females, about 15.8% of the total population in the Eastern part of Thailand (Office of the National Economic and Social Development Board, 2013). (Table 1) The average 3-year population (2013-2015) density was about 231.2 persons per square kilometer. The highest population density was 668.7 persons per square kilometer in the Muang Rayong district. The lowest population density was 80.3 persons per square kilometer in Wang Chan district. The population density is shown in Figure 1.2.

Table 1 Land area and an estimated population of the Eastern part of Thailand in 2014 (average 2013-2015)

Population Estimated Estimated Percentage Land area Estimated Province density population population of (km2) population (persons/km2) Male Female population Chonburi 343.5 4,363 1,498,767 718,433 780,333 28.8 Rayong 231.2 3,552 821,133 413,300 407,833 15.8 Chanthaburi 78.6 6,338 498,267 243,367 254,900 9.6 Trat 82.2 2,819 231,733 116,833 114,900 4.4 Chachoengsao 140.0 5,351 748,900 368,633 380,267 14.4 Sakeao 81.1 7,195 583,167 288,900 294,267 11.2 Prachinburi 120.9 4,762 575,600 279,867 295,733 11.0 Samut Prakarn 254.1 1,004 255,133 124,267 130,867 4.9 Eastern, 147.3 35,384 5,212,700 2,553,600 2,659,100 100.0 Thailand

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Introduction Cancer Incidence in Rayong, Thailand, 2013-2015

Figure 1.1 Map of the eastern region, Thailand

Figure 1.2 Estimated population densities by districts, Rayong (2013-2015).

Average population density = 231 per Square kilometer

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Methods Cancer Incidence in Rayong, Thailand, 2013-2015 METHODS Sources of Data All data on cancer patients were collected by the mixture of passive and active methods involving notification from the Chonburi Cancer Hospital, the Rayong provincial hospital, all community hospitals, some information from the National Cancer Institute, and information of deaths from the Death Certificate from the Bureau of Health Policy and Strategy, Ministry of Public Health. Individuals certified as having died of cancer, are registered as “Death Certificate Only (DCO)” cases. If there is no other information about the individual this can be traced from the other sources.

Registry Methods New cancer cases were collected from out and inpatient departments, wards, radiotherapy unit, surgery unit, cytology unit, hematology unit, medical record, pathological unit and autopsy service. The data information collected includes demographic details for each cancer patient that consists of registry number, name, residential address, date of birth, age, sex, date of diagnosis, site of cancer, histology of cancer, staging, the extension of disease, method of diagnosis, treatment, date of the last contact and status of cancer patients (alive or dead). The primary site and histology were coded according to the third edition of ICD-O (Fritz et al., 2000). Second primary cancer was also registered as a new registration number. Cases of carcinoma in situ were recorded but not included in the analyses. The computed data form was checked and extended into database files, using the NCI program for data entry and analysis.

Basis Diagnosis Types of diagnosis have been divided into two broad categories: histological and non histological confirmation. These are given below in approximate order of increased validity.

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Methods Cancer Incidence in Rayong, Thailand, 2013-2015

Non histological confirmation 0 Cancer cases which are diagnosed by Death certificate only 1 Clinical only 2 Clinical investigation (including, X-ray, ultrasound, CT scan, etc.) 3 Cases which are diagnosed by surgery or autopsy without histology 4 Specific immunological and/or Bio-chemical tests Histological confirmation 5 Cancer cytology or hematology 6 Histology of metastasis sites 7 Histology of primary tumor 8 Autopsy with histological.

Extension of Cancers Extension in cancer registration are used by the following items; 1 In situ 2 Localized 3 Direct extension 4 Regional nodes metastases 5 Distant metastases 8 Not applicable 9 Unknown

Staging of Cancers Staging of cancers in this cancer registration are used with the TNM Classification of Malignant Tumors of International Union against Cancer (UICC) seventh edition (Sobin et al., 2011).

Date of Diagnosis

All cancer registries have some registrations from death certificates only (DCO). If it is not possible to ascertain a date of diagnosis before death, the date of diagnosis is the same as the date of death, classified as a DCO.

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Methods Cancer Incidence in Rayong, Thailand, 2013-2015

Similarly, when the notification occurs only from an autopsy report, the date of diagnosis is the same as the date of death. Follow-up

Follow-up is very important for cancer registration. If it has a good follow-up, the analysis of cancer survival can be obtained. Follow-ups of cancer patients were performed in all cancer cases. A mixture of active and passive methods were carried out. Registered cases were first matched with death certificates. For the remaining cases thought to be alive, follow-up information was obtained by repeated scrutiny of hospital case records, postal enquires and if these measures failed to establish a patient’s vital status and home visits done by personals of the Public Health Service of Rayong.

Population dominators The population denominator used for calculation of rates, were taken from the population Projection report for Thailand 2010-2040 by the Population Projection Working Group, the Office of the National Economic and the Social Development Board, published in 2013 which provided an annual estimate by group and sex for each province in Thailand. The population pyramid of Rayong province is shown in Figure 2.1.

Statistical Methods Statistics from this report present the data on cancer incidence all malignancies for each cancer site, and sex in 8 districts of the province. The number of new cancers, age-specific incidence rates and age-standardized incidence rates of the three years by (2013-2015) and the population pyramid by districts. Definitions Age: The age of the patient (in complete years) at the time of diagnosis or death. Age groups: The basis for most statistics is the summation of cases by five-year age groups. Age groups are expressed in whole years, i.e. “5-9” means 5.0 to 9.99…. years. The population at risk: The population at risk is a part of the population that is susceptible, to have specific cancer. It is defined based on demographic data.

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Methods Cancer Incidence in Rayong, Thailand, 2013-2015 Incidence: The number of new cases of a given type of cancer diagnosed during the year. The basic unit of reporting is a new case of cancer rather than an individual patient, expressed as a rate per 100,000 persons in the population. Incidence is the number of new cancer cases in a defined population within a specific period time.

Calculation of Rates Rates: Rates in this report are calculated separately for males and females and expressed as cases per 100,000 person-years. If one year’s data are being analyzed, this is equivalent to n cases per 100,000 population for that year. Total Number of Cases (C): The total number of cases, calculated as the sum of cases in all age groups. Crude Incidence Rates: Crude rates are the number of new cases during the year, expressed as a rate per 100,000 persons in the population. Crude Incidence rates are calculated simply as the total new cancer cases divided by the total population over a wide age range, multiplied by 100,000 to give a rate per 100000. They are not suitable as a basis for comparison of the rates in different areas if the age-structures of the populations differ. Age-specific incidence Rates: Age-specific rates are the number of new cases of cancer or cancer deaths during the year, expressed as a rate per 100,000 persons in the population. Age-specific rate is the incidence in a specific age group. So age-specific rates are calculated by dividing the number of cancer cases in each five years age group and sex structure of the Rayong population in that age group and multiplied by 100,000. The rates are usually expressed per 100,000 of the population. AR = Ni/Pi x 100,000 Ni = Number of new cancer occurring in the age group Pi = Population of the age group in Rayong province Age-standardized Incidence Rates (ASR): Age-standardized incidence rate is a summary measure of a rate that a population will have if it has a standard age structure. It is calculated first by estimating the age-specific incidence rates and then applying these rates to the standard population. The most frequently used standard population is the world standard population (Doll et al., 1966); the calculated incidence rate is then called the world- standardized incidence rate. It is expressed per 100,000 population. Standardization is necessary

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Methods Cancer Incidence in Rayong, Thailand, 2013-2015 when comparing several populations that differ concerning age because age has a powerful influence on the risk of cancer. So they are suitable as a basis for comparison of the rates in different areas of the world.

Data Quality Control Quality control was carried out through the following indices. Morphologically Verified Percentage (%MV): The percentage of cases diagnosed was based on histology examination of tissue from the primary site or metastasis site, bone marrow, cytology and peripheral blood for leukemia. A low proportion of histological verification suggests over-reporting or it is very difficult to get a tissue diagnosis. A hundred percent of histological verification suggests under-reporting. Clinical cases were not included unless they were easy to get tissue diagnosis. Death Certificate Only Percentage (%DCO): Death Certificate Only Percentage is the percentage of cases where the diagnosis is based on information of a death certificate. All death certificates are matched against the registered cases in our files and traced back to existing data. The cases, which could not according to our data or be traced back to the relevant data, would be labeled as Dead Certificate Only. The date of death of this case is the date of diagnosis. The proportion of DCO registration is widely used as an indicator of ascertainment and data quality. If this percentage is high, it reflects the degree of under-reporting in the registry and is missing cancers as they are diagnosed. A low level of DCO (less than 5%) is regarded as an indicator of good data quality, a high degree of completeness. A very low or zero level of DCO cases may indicate that the registry is not receiving information on all deaths.

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Results Cancer Incidence in Rayong, Thailand, 2013-2015

RESULT OF ALL CANCER Incidence During the period 2013-2015, there were 3,521 incident cases of new cancer cases in Rayong residents, among 1,644 males, and 1,877 among females. The average age-standardized incidence rate was 131.6 per 100,000 population among males, and 125.9 among females (Table 2.3).

Age-Specific Incidence Rates The incidence rates were higher among females than males during the age of 20-55 years, for all other age groups incidence rates were higher among males than females. Due to high incidence rates of breast cancer and cervical cancer among females in the younger age group; lung and prostate cancer occurring in the older age among males (Figure 2.2)

Leading Cancers Lung cancer was the most common cancer (ASR = 21.3 per 100,000 population) followed by liver cancer 17.3, colorectal cancer 16.6, esophageal cancer 7.6, prostate cancer 7.5, oral cavity cancer 5.8, leukemia 5.6, bladder cancer 5.2, Non-Hodgkin lymphoma 4.2 and laryngeal cancer 3.5 among males (Figure 2.3). Breast cancer was the most common cancer (ASR = 30.1 per 100,000 population) followed by cervical cancer 14.6, lung cancer 12.6, colorectal cancer 10.4, liver cancer 7.4, ovarian cancer 6, thyroid cancer 5.9, corpus cancer 4.9 and Non-Hodgkin lymphoma 3.4 among females (Figure 2.3).

Data Quality of All Cancers The average histological verified was 77.8% in both sexes, 72.9% for males and 82.1% for females. An average DCO was 3.6% for both sexes, 4.9% for males and 2.5% for females, females had better prognosis than males (Table 2.4).

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Figure 2.1 Population pyramid in Rayong province estimated population in 2014 (average 2013-2015)

8,433 75+ 8,433 6,800 70-74 6,800 9,267 65-69 9,267 13,333 60-64 13,333 19,433 55-59 19,433 26,100 50-54 26,100

33,067 45-49 33,067 39,067 40-44 39,067 44,133 35-39 44,133 43,633 30-34 43,633

35,167 25-29 35,167 29,533 20-24 29,533 26,867 15-19 26,867 24,967 10-14 24,967 24,167 5-9 24,167 29,333 0-4 29,333 90 80 70 60 50 40 30 20 10 0 0 10 20 30 40 50 60 70 80 90 MALE (1,000 PERSONS) FEMALE (1,000 PERSONS) Figure 2.2 Age-specific incidence rates of all in Rayong, mean annual rate per 100,000.

(2013-2015)

ASR per 100,000 per ASR

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Results Cancer Incidence in Rayong, Thailand, 2013-2015

Figure 2.3 Leading cancer in Rayong (mean annual ASR 2013-2015)

ASR (World)

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Figure 2.4 Stage of all cancer in Rayong (mean annual ASR 2013-2015)

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Results

Cancer Incidence in Rayong, Thailand, 2013-2015

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0.1

0.0

4.8 -

0 Cum

C95

C91

C90

C81

C75

C74

C73

C69

C67

C66

C65

C64

C62

C61

C60

C58

C57

C56

C55

C54

C53

C52

C51

C50

C46

C45

C44

C43

C32

C25

C23

C21

C18

C17

C16

C15

C14

C11

C10

C09

C00

ALL

O&U

C92-94

C70-72

C37-38

C33-34

C30-31

C19-20

C12-13

C07-08 C03-06

C01-02

ICD-10

C47,C49

C22,C24

C40-C41 D45-D47

C82-85,C96

0 2

5.7

1.3

2.6

1.7

1.2

4.2

0.1

0.2

1.4

2.1

0.1

5.2

0.1

1.2

0.5

7.5

1.1

0.3

1.3

0.1

2.9

0.3

1.4

0.7

3.5

0.2

2.2

0.7

0.4

6.4

9.8

0.5

3.2

7.6

0.2

1.7

3.4

0.6

1.2

1.5

0.1

21.3 17.3

131.6

ASRWorld

5.7

1.2

1.1

2.7

1.3

1.1

4.7

0.1

0.2

1.7

2.3

0.1

4.8

0.2

1.3

0.6

6.7

1.2

0.2

1.5

0.1

2.7

0.4

1.2

0.6

3.5

0.2

2.3

0.6

0.4

6.5

9.5

0.6

3.3

7.3

0.2

1.8

4.1

0.6

2.2

1.2

1.6

3.2 0.1

18.5 132.6

CrudeRate

0 0

4.9

9.8

4.9

9.8

4.9

9.8

4.9

9.8

4.9

9.8

4.9

24.5

14.7

34.3

19.6

14.7

83.3

73.5

88.2

24.5

34.3

14.7

75+ 191.2

887.3

Male

3.6

7.2

3.6

7.2

3.6

7.2

3.6

7.2

3.6 7.2

70-

25.2

10.8

43.2

57.6

25.2

10.8

25.2

10.8

89.9

21.6

71.9

57.6

10.8

104.3 683.5 -

2.5

7.5

2.5

7.5

2.5

65-

520

27.5

17.5

12.5 27.5 32.5

0 0

1.7

5.1

3.4

1.7

8.6

1.7

8.6

5.1

1.7

8.6

3.4

5.1

1.7

6.9

1.7

5.1

3.4

5.1

3.4

6.9

60-

15.4

13.7

53.2

78.9

22.3

20.6

17.2

17.2 13.7

351.6

1.3

2.6

8.9

1.3

2.6

1.3

3.8

1.3

3.8

2.6

1.3

2.6

1.3

8.9

2.6

8.9

2.6

1.3

8.9

7.7

3.8

2.6 3.8

55-

11.5

10.2

43.4

47.3

12.8 21.7

238.8

9.1

50-

18.1

23.2 11.1 11.1

142.1

2015) by Age Group 2015)Age by Group

0 0

4.3

0.9

1.7

4.3

3.4

0.9

1.7

0.9

5.1

2.6

4.3

5.1

2.6

3.4

7.7

1.7

3.4

45-

14.5 76.8 –

3 3

2.3

1.5

0.8

4.5

0.8

2.3

0.8

2.3

0.8

1.5

5.3

0.8

2.3

0.8

3.8

1.5

0.8

1.5 0.8

40- 45.3

0.8

2.3

0.8

3.8

1.5

0.8

1.5

7.6

1.5

0.8

3.1

1.5

1.5 35-

29.8

0 0

1.9

0.9

3.8

0.9

1.9

0.9

1.9 30- 17.1

1.1

2.3

1.1

2.3

1.1

1.1 1.1

25- 18.1

1.2

2.5

1.2 8.7 20-

0 0

1.3

5.3

1.3

1.3 15- 10.7

1.4

2.8

1.4

1.4 9.7 10-

2.3

3.4

4.5

1.1

1.1 1.1

13.6

0 0

30 17

13 548 Year No.Case

Rayong (2014), Mean annual ASR per annual (2014), (20 100,000 Rayong Mean

Allsites

Otherunspecified and

Myelodysplastic disease Myelodysplastic

Leukemiaunspecified

Myeloid leukemia Myeloid

Lymphoid leukemia Lymphoid

Multiplemyeloma

Non-Hodgkinlymphoma

Hodgkindisease

Otherendocrine

Adrenal gland Adrenal

Thyroid

Brain,nervous system

Eye

Bladder

Ureter

Renal pelvis Renal

Kidney

Testis

Prostate

Penis

Placenta

Othergenitalfemale organs

Ovary

Uterusunspecified

Corpusuteri

Cervixuteri

Vagina

Vulva

Breast

Connective tissueConnective

Kaposi's sarcoma Kaposi's

Mesothelioma

Otherskin

Melanoma of skin of Melanoma

Bone

Otherorgans thoracic

Trachea, BronchusTrachea, lung and

Larynx

Nose, sinuses Nose, etc.

Pancreas

Gallbladder

Liver and bileduct and Liver

Anus

Rectum

Colon

Small intestine Small

Stomach

Oesophagus

Pharynx unspecifiedPharynx

Hypopharynx

Nasopharynx

Otheroropharynx

Tonsil

Salivary glands Salivary

Mouth

Tongue

Lip Site

Table 2.1Table 13 | P a g e

Results Cancer Incidence in Rayong, Thailand, 2013-2015

0.4

0.0

0.1

0.5

0.0

0.6

0.2

0.0

0.1

0.0

0.1

0.0

0.7

0.1

0.6

1.6

0.0

3.3

0.1

0.0

0.2

0.0

0.1

0.0

1.6

0.0

0.1

0.0

0.9

0.0

0.5

0.8

0.0

0.2

0.1

0.0

0.1

0.0

0.1

0.1 0.0

13.9 0 Rate

0.2

0.0

0.1

0.0

0.1

0.2

0.0

0.4

0.2

0.0

0.1

0.0

0.5

0.1

0.4

1.1

0.0

2.4

0.1

0.0

0.1

0.0

0.1

0.0

0.7

0.0

0.1

0.0

0.4

0.0

0.2

0.4

0.0

0.2

0.1

0.0

0.1

0.0

0.1

0.0

8.6 -

0 Cum

C95

C91

C90

C81

C75

C74

C73

C69

C67

C66

C65

C64

C62

C61

C60

C58

C57

C56

C55

C54

C53

C52

C51

C50

C46

C45

C44

C43

C32

C25

C23

C21

C18

C17

C16

C15

C14

C11

C10

C09

C00

ALL

O&U

C92-94

C70-72

C37-38

C33-34

C30-31

C19-20

C12-13

C07-08 C03-06

C01-02

ICD-10

C47,C49

C22,C24

C40-C41 D45-D47

C82-85,C96

3.2

0.4

0.5

1.3

1.0

1.2

3.4

0.4

0.1

5.9

2.3

0.1

1.4

0.1

0.2

0.7

0.0

0.1

0.2

6.0

0.7

4.9

0.2

1.0

0.0

0.1

2.5

0.1

1.0

0.3

0.2

0.3

1.3

0.6

7.4

0.2

3.6

6.6

0.3

2.2

1.4

0.0

0.3

1.4

0.0

0.1

0.5

0.9

1.0

0.5

14.6

30.4 12.6

125.9

ASRWorld

3.6

0.6

0.4

1.3

0.9

1.4

3.6

0.4

0.1

7.1

2.1

0.1

1.7

0.1

0.2

0.7

0.0

0.1

0.2

7.4

0.7

5.9

0.2

0.3

1.2

0.0

0.2

3.2

0.2

1.0

0.3

0.2

0.4

1.7

0.8

8.5

0.2

4.2

8.3

0.3

2.8

1.7

0.0

0.4

1.9

0.0

0.2

0.6

1.0

1.2

0.7

18.6 39.3 15.0

153.3

CrudeRate

5.2

2.6

5.2

7.8

2.6

0.0

7.8

0.0

2.6

0.0

5.2

0.0

5.2

2.6

0.0

2.6

0.0

5.2

2.6

0.0

2.6

0.0

7.8

5.2

ale

26.0

20.8

15.6

51.9

39.0

18.2

57.1

26.0

49.4

13.0

26.0

13.0

75+ 111.7 613.0

Fem

0.0

4.1

0.0

8.2

4.1

0.0

4.1

0.0

4.1

0.0

8.2

0.0

4.1

0.0

4.1

0.0

4.1

0.0

4.1

4.1 4.1

70-

20.6

37.0

16.5

12.3

24.7

20.6

24.7

61.7

12.3

37.0

32.9

49.4

12.3

111.1 543.2 -

0.0

3.1

0.0

6.2

0.0

9.3

0.0

3.1

6.2

0.0

9.3

3.1

0.0

3.1

0.0

6.2

0.0

3.1

0.0

3.1

0.0

3.1

0.0

6.2

0.0

3.1

0.0

9.3

6.2

0.0

65-

18.7

12.5

21.8

15.6

18.7

77.9

71.7

56.1

18.7 21.8

105.9 529.6

2.1

6.4

0.0

2.1

0.0

6.4

0.0

6.4

0.0

2.1

0.0

2.1

0.0

2.1

0.0

8.5

0.0

2.1

0.0

2.1

0.0

2.1

60-

14.9

10.6

19.1

29.7

36.1

82.8

10.6

57.3

38.2

17.0

23.4 14.9

431.0

6.4

0.0

1.6

6.4

1.6

8.1

3.2

0.0

4.8

0.0

4.8

0.0

1.6

0.0

1.6

0.0

3.2

0.0

8.1

0.0

1.6

4.8

0.0

1.6

4.8

0.0

3.2

8.1

0.0

3.2

1.6

0.0

1.6

3.2

1.6

0.0

55-

11.3

20.9

14.5

45.1

93.4

25.8

20.9 12.9 17.7 352.7

3.6

1.2

0.0

1.2

8.5

0.0

2.4

0.0

2.4

0.0

1.2

0.0

1.2

0.0

1.2

2.4

0.0

2.4

1.2

0.0

1.2

4.8

1.2

4.8

1.2

6.1

0.0

4.8

2.4

0.0

1.2

6.1

0.0

1.2

2.4

0.0

1.2

0.0

50-

15.7

13.3

15.7

47.2

16.9

16.9 106.5

303.9

2015) by Age Group 2015)Age by Group

2.0

1.0

0.0

1.0

0.0

3.9

0.0

8.8

2.0

0.0

2.0

0.0

1.0

0.0

3.9

6.8

1.0

0.0

1.0

0.0

2.9

0.0

1.0

8.8

0.0

1.0

0.0

3.9

0.0

8.8

0.0

1.0 1.0

0.0

45-

22.4

32.2

83.9

11.7

10.7 – 224.4

3 3

1.8

0.0

1.8

0.0

0.9

0.0

0.9

0.0

0.9

9.8

0.0

3.6

0.0

0.9

0.0

2.7

0.0

0.9

0.0

0.9

0.0

2.7

0.0

3.6

8.0

0.9

1.8

0.0

1.8

0.0

1.8

0.9

40-

10.7

19.6 56.1 14.2 149.6

0.8

0.0

0.8

0.0

0.8

0.0

7.3

0.0

0.8

0.0

1.6

0.0

4.1

0.0

0.8

0.0

0.8

0.0

3.3

0.0

1.6

0.0

0.8

3.3

0.0

1.6

0.0

1.6

0.0

1.6

0.0

35-

20.4 41.6 95.5

1.6

0.0

0.8

0.0

1.6

0.8

0.0

4.9

0.0

2.4

0.0

2.4

7.3

0.8

1.6

0.0

0.8

0.0

0.8

0.0

0.8

0.0

3.2

0.0

1.6

0.0

1.6

0.0

0.8

0.0

1.6

0.0 0.8

0.0

30- 14.6 51.9

0.0

2.1

1.0

0.0

6.2

2.1

0.0

6.2

0.0

4.2

0.0

7.3

0.0

1.0

0.0

1.0

0.0 25-

32.3

0.0

2.4

0.0

3.6

0.0

6.0

1.2

0.0

1.2

0.0

1.2

0.0

1.2

0.0

1.2

0.0

1.2

0.0

1.2

0.0

1.2

0.0 20- 26.2

1.3

0.0

1.3

2.7

1.3

0.0

1.3

0.0

2.7

0.0

1.3

0.0

1.3

0.0

1.3

0.0

1.3

0.0

0.0 0.0

15- 16.2

0.0

1.4

0.0

1.4

0.0

1.4

0.0

1.4

0.0

1.4

0.0

0.0 8.3 10-

0.0

1.5

0.0

4.4

0.0

1.5

0.0

1.5

0.0

0.0 0.0 8.8

1.2

0.0

1.2

0.0

1.2

0.0

1.2

0.0

2.4

0.0

0.0 0.0 0.0

11.0

4 5

160 626

Year

No.Case

Rayong (2014), Mean annual ASR per annual (2014), (20 100,000 Rayong Mean

Allsites

Otherunspecified and

Myelodysplastic disease Myelodysplastic

Leukemiaunspecified

Myeloid leukemia Myeloid

Lymphoid leukemia Lymphoid

Multiplemyeloma

Non-Hodgkinlymphoma

Hodgkindisease

Otherendocrine

Adrenal gland Adrenal

Thyroid

Brain,nervous system

Eye

Bladder

Ureter

Renal pelvis Renal

Kidney

Testis

Prostate

Penis

Placenta

Othergenitalfemale organs

Ovary

Uterusunspecified

Corpusuteri

Cervixuteri

Vagina

Vulva

Breast

Connective tissueConnective

Kaposi's sarcoma Kaposi's

Mesothelioma

Otherskin

Melanoma of skin of Melanoma

Bone

Otherorgans thoracic

Trachea, BronchusTrachea, lung and

Larynx

Nose, sinuses Nose, etc.

Pancreas

Gallbladder

Liver and bileduct and Liver

Anus

Rectum

Colon

Small intestine Small

Stomach

Oesophagus

Pharynx unspecifiedPharynx

Hypopharynx

Nasopharynx

Otheroropharynx

Tonsil

Salivary glands Salivary

Mouth

Tongue

Lip

Site Table 2. Table

14 | P a g e

Results Cancer Incidence in Rayong, Thailand, 2013-2015 Table 2.3 Mean annual incidence, Rayong, 2013 - 2015 Male Female Crude ASR Cum. Rate. Crude ASR Cum. Rate. Site No.Cases Freq. No.Cases Freq. ICD-10 rate world 0-64 0-74 rate world 0-64 0-74 Year (%) Year (%) (per 100,000) (percent) (per 100,000) (percent) Lip 0 0.1 0.1 0.1 0.0 0.0 3 0.4 0.7 0.5 0.0 0.0 C00 Tongue 13 2.4 3.2 3 0.0 0.1 5 0.8 1.2 1 0.0 0.0 C01-02 Mouth 7 1.2 1.6 1.5 0.0 0.0 4 0.6 1 0.9 0.0 0.0 C03-06 Salivary glands 5 0.9 1.2 1.2 0.0 0.0 2 0.4 0.6 0.5 0.0 0.0 C07-08 Tonsil 9 1.6 2.2 2 0.0 0.0 1 0.1 0.2 0.1 0.0 0.0 C09 Other oropharynx 2 0.4 0.6 0.6 0.0 0.0 0 0.0 0 0 0.0 0.0 C10 Nasopharynx 17 3.1 4.1 3.4 0.1 0.1 8 1.2 1.9 1.4 0.0 0.0 C11 Hypopharynx 7 1.3 1.8 1.7 0.0 0.0 2 0.3 0.4 0.3 0.0 0.0 C12-13 Pharynx unspecified 1 0.2 0.2 0.2 0.0 0.0 0 0.0 0 0 0.0 0.0 C14 Oesophagus 30 5.5 7.3 7.6 0.1 0.1 7 1.1 1.7 1.4 0.0 0.0 C15 Stomach 14 2.5 3.3 3.2 0.0 0.1 11 1.8 2.8 2.2 0.0 0.0 C16 Small intestine 2 0.4 0.6 0.5 0.0 0.0 1 0.2 0.3 0.3 0.0 0.0 C17 Colon 39 7.2 9.5 9.8 0.1 0.2 34 5.4 8.3 6.6 0.1 0.1 C18 Rectum 27 4.9 6.5 6.4 0.1 0.1 17 2.7 4.2 3.6 0.0 0.1 C19-20 Anus 2 0.3 0.4 0.4 0.0 0.0 1 0.2 0.2 0.2 0.0 0.0 C21 Liver and bile duct 77 14.0 18.5 17.3 0.3 0.4 35 5.5 8.5 7.4 0.1 0.1 C22,C24 Gallbladder 2 0.4 0.6 0.7 0.0 0.0 3 0.5 0.8 0.6 0.0 0.0 C23 Pancreas 9 1.7 2.3 2.2 0.0 0.0 7 1.1 1.7 1.3 0.0 0.0 C25 Nose, sinuses etc. 1 0.2 0.2 0.2 0.0 0.0 2 0.3 0.4 0.3 0.0 0.0 C30-31 Larynx 14 2.6 3.5 3.5 0.0 0.1 1 0.2 0.2 0.2 0.0 0.0 C32 Trachea, Bronchus and lung 87 15.8 21 21.3 0.2 0.3 61 9.7 15 12.6 0.2 0.2 C33-34 Other thoracic organs 3 0.5 0.6 0.7 0.0 0.0 1 0.2 0.3 0.3 0.0 0.0 C37-38 Bone 5 0.9 1.2 1.4 0.0 0.0 4 0.6 1 1 0.0 0.0 C40-C41 Melanoma of skin 2 0.3 0.4 0.3 0.0 0.0 1 0.1 0.2 0.1 0.0 0.0 C43 Other skin 11 2.1 2.7 2.9 0.0 0.0 13 2.1 3.2 2.5 0.0 0.0 C44 Mesothelioma 0 0.0 0 0 0.0 0.0 1 0.1 0.2 0.1 0.0 0.0 C45 Kaposi's sarcoma 0 0.1 0.1 0.1 0.0 0.0 0 0.0 0 0 0.0 0.0 C46 Connective tissue 6 1.1 1.5 1.3 0.0 0.0 5 0.8 1.2 1 0.0 0.0 C47,C49 Breast 1 0.2 0.2 0.3 0.0 0.0 160 25.6 39.3 30.4 0.7 0.8 C50 Vulva 1 0.2 0.3 0.2 0.0 0.0 C51 Vagina 1 0.2 0.2 0.2 0.0 0.0 C52 Cervix uteri 76 12.1 18.6 14.6 0.3 0.3 C53 Corpus uteri 24 3.8 5.9 4.9 0.1 0.1 C54 Uterus unspecified 3 0.5 0.7 0.7 0.0 0.0 C55 Ovary 30 4.8 7.4 6 0.1 0.1 C56 Other female genital organs 1 0.2 0.2 0.2 0.0 0.0 C57 Placenta 0 0.1 0.1 0.1 0.0 0.0 C58 Penis 5 0.9 1.2 1.1 0.0 0.0 C60 Prostate 28 5.0 6.7 7.5 0.0 0.1 C61 Testis 2 0.4 0.6 0.5 0.0 0.0 C62 Kidney 5 1.0 1.3 1.2 0.0 0.0 3 0.5 0.7 0.7 0.0 0.0 C64 Renal pelvis 1 0.1 0.2 0.1 0.0 0.0 1 0.1 0.2 0.2 0.0 0.0 C65 Ureter 0 0.0 0 0 0.0 0.0 0 0.1 0.1 0.1 0.0 0.0 C66 Bladder 20 3.6 4.8 5.2 0.0 0.1 7 1.1 1.7 1.4 0.0 0.0 C67 Eye 0 0.1 0.1 0.1 0.0 0.0 0 0.1 0.1 0.1 0.0 0.0 C69 Brain, nervous system 9 1.7 2.3 2.1 0.0 0.0 9 1.4 2.1 2.3 0.0 0.0 C70-72 Thyroid 7 1.3 1.7 1.4 0.0 0.0 29 4.6 7.1 5.9 0.1 0.1 C73 Adrenal gland 1 0.2 0.2 0.2 0.0 0.0 0 0.1 0.1 0.1 0.0 0.0 C74 Other endocrine 0 0.1 0.1 0.1 0.0 0.0 0 0.1 0.1 0.1 0.0 0.0 C75 Hodgkin disease 0 0.1 0.1 0.1 0.0 0.0 2 0.3 0.4 0.4 0.0 0.0 C81 Non-Hodgkin lymphoma 19 3.5 4.7 4.2 0.1 0.1 15 2.3 3.6 3.4 0.0 0.1 C82-85,C96 Multiple myeloma 5 0.9 1.1 1.2 0.0 0.0 6 0.9 1.4 1.2 0.0 0.0 C90 Lymphoid leukemia 5 1.0 1.3 1.7 0.0 0.0 4 0.6 0.9 1 0.0 0.0 C91 Myeloid leukemia 11 2.1 2.7 2.6 0.0 0.1 5 0.9 1.3 1.3 0.0 0.0 C92-94 Leukemia unspecified 5 0.9 1.1 1.3 0.0 0.0 2 0.3 0.4 0.5 0.0 0.0 C95 Myelodysplastic disease 5 0.9 1.2 1.3 0.0 0.0 2 0.4 0.6 0.4 0.0 0.0 D45-D47 Other and unspecified 24 4.3 5.7 5.7 0.1 0.1 15 2.3 3.6 3.2 0.0 0.1 O&U All sites 548 100.0 132.6 131.6 1.7 2.3 626 100.0 153.3 125.9 2.2 2.7 ALL 15 | P a g e

Results Cancer Incidence in Rayong, Thailand, 2013-2015 Table 2.4 Percentage of morphologically verified and death certificate only cases, Rayong Male Female Site Cases Cases ICD-10 %MV %DCO %MV %DCO 3 Year 3 Year Oral cavity 76 94.7 1.3 42 95.2 0.0 C00-C08 Oropharynx 37 94.6 0.0 2 100.0 0.0 C09-C10,C14 Nasopharynx 51 88.2 2.0 23 82.6 0.0 C11 Hypopharynx 22 95.5 0.0 5 80.0 0.0 C12-C13 Esophagus 91 79.1 0.0 21 71.4 4.8 C15 Stomach 41 78.0 2.4 34 79.4 5.9 C16 Small intestine 7 71.4 14.3 4 100.0 0.0 C17 Colon and rectum 204 85.3 1.0 156 88.5 0.6 C18-C21 Liver and bile duct 230 23.5 14.3 104 20.2 15.4 C22,C24 Gallbladder 7 57.1 0.0 10 30.0 0.0 C23 pancrease 28 46.4 3.6 21 38.1 9.5 C25 Nose,sinuses etc 3 100.0 0.0 5 80.0 0.0 C30-C31 Larynx 43 83.7 2.3 3 100.0 0.0 C32 Trachea, brochus and lung 260 70.0 6.5 183 77.0 4.4 C33-C34 Other thoracic organs 8 75.0 12.5 4 75.0 0.0 C37-C38 Bone 15 46.7 6.7 12 66.7 0.0 C40-C41 Melanoma of skin 5 100.0 0.0 2 100.0 0.0 C43 Other skin 34 97.1 0.0 39 97.4 0.0 C44 Mesothelioma 0 0.0 0.0 2 100.0 0.0 C45 Kaposi sarcoma 1 100.0 0.0 0 0.0 0.0 C46 Connective and soft tissue 18 94.4 0.0 15 100.0 0.0 C47,C49 Breast 3 100.0 0.0 481 91.9 1.0 C50 Vulva 4 75.0 0.0 C51 Vagina 3 100.0 0.0 C52 Cervix uteri 228 89.9 0.9 C53 Corpus uteri 72 93.1 0.0 C54 Uterus unspecified 9 77.8 11.1 C55 Ovary 91 71.4 0.0 C56 Other female genital organs 3 100.0 0.0 C57 Placenta 1 100.0 0.0 C58 Penis 15 100.0 0.0 C60 Prostate 83 77.1 2.4 C61 Testis 7 100.0 0.0 C62 Other male genital organs 0 0.0 0.0 C63 Kidney 16 81.3 6.3 9 66.7 0.0 C64 Renal pelvis 2 50.0 0.0 2 100.0 0.0 C65 Ureter 0 0.0 0.0 1 100.0 0.0 C66 Bladder 60 98.3 0.0 21 81.0 4.8 C67 Other urinary organs 0 0.0 0.0 0 0.0 0.0 C68 Eye 1 0.0 0.0 1 100.0 0.0 C69 Brain, nervous system 28 57.1 10.7 26 65.4 3.8 C70-C72 Thyroid 21 95.2 0.0 87 92.0 0.0 C73 Adrenal gland 3 66.7 33.3 1 100.0 0.0 C74 Other endocrine 1 100.0 0.0 1 100.0 0.0 C75 Hodgkin disease 1 100.0 0.0 5 100.0 0.0 C81 Non-Hodgkin lymphoma 58 100.0 0.0 44 100.0 0.0 C82-C85,C96 Immunoproliferative diseases 0 0.0 0.0 0 0.0 0.0 C88 Multiple myeloma 14 100.0 0.0 17 100.0 0.0 C90 Leukemia 64 100.0 0.0 32 100.0 0.0 C91-C95 Myelodysplastic 15 100.00 0.0 7 100.0 0.0 D45-D47 Other and unspecified 71 39.44 19.7 44 38.6 15.9 O&U All sites 1,644 72.9 4.9 1,877 82.1 2.5 All All sites without liver 1,414 80.9 3.4 1,773 85.7 1.7 All 16 | P a g e

Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 PATHOLOGY Table 2.5 Pathology according to sites and sexes of all cancers

Pathology and Sites Male Female Total C00 LIP 8 1 9 8051 Verrucous carcinoma, NOS 2 0 2 8070 Squamous cell carcinoma, NOS 6 1 7

C01 BASE OF TONGUE 1 10 11 8010 Carcinoma, NOS 1 0 1 8070 Squamous cell carcinoma, NOS 0 10 10

C02 TONGUE AND UNSPECIFIED PARTS OF TONGUE 14 30 44 8000 No histological proof 0 1 1 8051 Verrucous carcinoma, NOS 0 1 1 8070 Squamous cell carcinoma, NOS 14 28 42

C03 GUM 2 2 4 8070 Squamous cell carcinoma, NOS 2 2 4

C04 FLOOR OF MOUTH 0 4 4 8070 Squamous cell carcinoma, NOS 0 4 4

C05 PALATE 4 6 10 8070 Squamous cell carcinoma, NOS 3 6 9 9680 Malignant lymphoma, large B-cell, diffuse, NOS 1 0 1

C06 OTHER AND UNSPECIFIED PARTS OF MOUTH 7 8 15 8000 No histological proof 1 1 2 8070 Squamous cell carcinoma, NOS 6 7 13

C07 PAROTID GLAND 4 10 14 8000 No histological proof 0 1 1

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Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total 8010 Carcinoma, NOS 1 2 3 8070 Squamous cell carcinoma, NOS 0 1 1 8140 Adenocarcinoma, NOS 0 1 1 8200 Adenoid cystic carcinoma 1 1 2 8430 Mucoepidermoid carcinoma 0 2 2 8550 Acinar cell carcinoma 1 0 1 8941 Carcinoma in pleomorphic adenoma 1 0 1 8982 Malignant myoepithelioma 0 2 2

C08 OTHER AND UNSPECIFIED MAJOR SALIVARY GLANDS 3 5 8 8000 No histological proof 1 1 2 8200 Adenoid cystic carcinoma 1 2 3 8550 Acinar cell carcinoma 0 1 1 8940 Mixed tumor, malignant, NOS 1 0 1 8982 Malignant myoepithelioma 0 1 1

C09 TONSIL 2 30 32 8000 No histological proof 0 2 2 8020 Carcinoma, undifferentiated, NOS 0 1 1 8070 Squamous cell carcinoma, NOS 2 22 24 8071 Squamous cell carcinoma, keratinizing, NOS 0 1 1 8072 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 0 0 1 9590 Malignant lymphoma, NOS 0 1 1 9680 Malignant lymphoma, large B-cell, diffuse, NOS 0 2 2

C10 OROPHARYNX 0 7 7 8010 Carcinoma, NOS 0 1 1 8070 Squamous cell carcinoma, NOS 0 6 6

C11 NASOPHARYNX 23 51 74 8000 No histological proof 4 6 10 8010 Carcinoma, NOS 4 3 7 8020 Carcinoma, undifferentiated, NOS 6 15 21

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Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total 8070 Squamous cell carcinoma, NOS 2 11 13 8071 Squamous cell carcinoma, keratinizing, NOS 0 2 2 8072 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 7 13 20 8806 Desmoplastic small round cell tumor 0 1 1

C12 PYRIFORM SINUS 1 17 18 8000 No histological proof 0 1 1 8010 Carcinoma, NOS 0 1 1 8070 Squamous cell carcinoma, NOS 1 14 15 8073 Squamous cell carcinoma, small, nonkeratinizing 0 1 1

C13 HYPOPHARYNX 4 5 9 8000 No histological proof 1 0 1 8010 Carcinoma, NOS 1 0 1 8070 Squamous cell carcinoma, NOS 2 5 7

C14 PHARYNX 0 3 3 8070 Squamous cell carcinoma, NOS 0 3 3

C15 ESOPHAGUS 21 91 112 8000 No histological proof 6 19 25 8001 Tumor cells, malignant 1 0 1 8070 Squamous cell carcinoma, NOS 12 68 80 8073 Squamous cell carcinoma, small, nonkeratinizing 0 1 1 8140 Adenocarcinoma, NOS 1 2 3 8490 Signet ring cell carcinoma 0 1 1 8936 Gastrointestinal stromal sarcoma 1 0 1

C16 STOMACH 34 41 75 8000 No histological proof 8 9 17 8010 Carcinoma, NOS 0 1 1 8032 Spindle cell carcinoma, NOS 0 1 1 8070 Squamous cell carcinoma, NOS 1 2 3

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Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total 8140 Adenocarcinoma, NOS 6 17 23 8145 Carcinoma, diffuse type 1 0 1 8255 Adenocarcinoma with mixed subtypes 0 1 1 8480 Mucinous adenocarcinoma 0 2 2 8490 Signet ring cell carcinoma 15 6 21 8806 Desmoplastic small round cell tumor 1 1 2 8936 Gastrointestinal stromal sarcoma 2 1 3

C17 SMALL INTESTINE 4 8 12 8000 No histological proof 0 2 2 8032 Spindle cell carcinoma, NOS 0 1 1 8033 Pseudosarcomatous carcinoma 1 0 1 8140 Adenocarcinoma, NOS 1 1 2 8144 Adenocarcinoma, intestinal type 0 1 1 8852 Myxoid liposarcoma 0 1 1 8936 Gastrointestinal stromal sarcoma 2 1 3 9591 Malignant lymphoma, non - Hodgkin, NOS 0 1 1

C18 COLON 101 118 219 8000 No histological proof 14 21 35 8010 Carcinoma, NOS 1 1 2 8140 Adenocarcinoma, NOS 80 91 171 8290 Oxyphilic adenocarcinoma 0 1 1 8480 Mucinous adenocarcinoma 3 3 6 8490 Signet ring cell carcinoma 3 1 4

C19 RECTOSIGMOID JUNCTION 8 7 15 8140 Adenocarcinoma, NOS 8 7 15

C20 RECTUM 43 74 117 8000 No histological proof 4 8 12 8010 Carcinoma, NOS 1 0 1 8140 Adenocarcinoma, NOS 34 61 95

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Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total 8262 Villous adenocarcinoma 1 1 2 8480 Mucinous adenocarcinoma 3 2 5 8560 Adenosquamous carcinoma 0 1 1 8936 Gastrointestinal stromal sarcoma 0 1 1

C21 ANUS AND ANAL CANAL 4 5 9 8000 No histological proof 0 1 1 8020 Carcinoma, undifferentiated, NOS 1 1 2 8070 Squamous cell carcinoma, NOS 1 0 1 8140 Adenocarcinoma, NOS 1 2 3 8490 Signet ring cell carcinoma 0 1 1 8936 Gastrointestinal stromal sarcoma 1 0 1

C22 LIVER AND INTRAHEPATIC BILE DUCTS 97 222 319 8000 No histological proof 78 171 249 8010 Carcinoma, NOS 4 9 13 8140 Adenocarcinoma, NOS 3 7 10 8160 Cholangiocarcinoma 3 6 9 8170 Hepatocellular carcinoma, NOS 7 28 35 8180 Combined hepatocellular carcinoma and cholangiocarcinoma 1 0 1 8200 Adenoid cystic carcinoma 0 1 1 8970 Hepatoblastoma 1 0 1

C23 GALL BLADDER 10 7 17 8000 No histological proof 7 4 11 8140 Adenocarcinoma, NOS 2 2 4 8160 Cholangiocarcinoma 1 0 1 8310 Clear cell adenocarcinoma, NOS 0 1 1

C24 OTHER AND UNSPECIFIED PARTS OF BILIARY TRACT 7 8 15 8000 No histological proof 5 6 11 8140 Adenocarcinoma, NOS 2 1 3 8490 Signet ring cell carcinoma 0 1 1

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Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total C25 PANCREAS 21 28 49 8000 No histological proof 13 15 28 8010 Carcinoma, NOS 1 1 2 8140 Adenocarcinoma, NOS 5 11 16 8154 Mixed pancreatic endocrine and exocrine tumor, malignant 0 1 1 8452 Solid pseudopapillary carcinoma 1 0 1 8480 Mucinous adenocarcinoma 1 0 1

C26 OTHER AND ILL-DEFINED DIGESTIVE ORGANS 3 7 10 8000 No histological proof 3 7 10

C30 NASAL CAVITY AND MIDDLE EAR 4 3 7 8000 No histological proof 1 0 1 8020 Carcinoma, undifferentiated, NOS 0 1 1 8070 Squamous cell carcinoma, NOS 1 0 1 8072 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 0 1 1 8550 Acinar cell carcinoma 0 1 1 8800 Sarcoma, NOS 1 0 1 9522 Olfactory neuroblastoma 1 0 1

C31 ACCESSORY SINUSES 1 0 1 8070 Squamous cell carcinoma, NOS 1 0 1

C32 LARYNX 3 43 46 8000 No histological proof 0 7 7 8070 Squamous cell carcinoma, NOS 3 36 39

C34 TRACHEA, BRONCHUS, AND LUNG 185 261 446 8000 No histological proof 42 78 120 8010 Carcinoma, NOS 22 27 49 8020 Carcinoma, undifferentiated, NOS 0 1 1 8041 Small cell carcinoma, NOS 4 6 10 8046 Non-smal cell carcinoma 15 17 32

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Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total 8051 Verrucous carcinoma, NOS 0 1 1 8070 Squamous cell carcinoma, NOS 13 32 45 8140 Adenocarcinoma, NOS 75 88 163 8200 Adenoid cystic carcinoma 1 1 2 8250 Bronchiolo-alveolar adenocarcinoma, NOS 6 5 11 8260 Papillary adenocarcinoma, NOS 2 1 3 8430 Mucoepidermoid carcinoma 1 0 1 8481 Mucin-producing adenocarcinoma 1 0 1 8490 Signet ring cell carcinoma 0 1 1 8550 Acinar cell carcinoma 1 0 1 8560 Adenosquamous carcinoma 0 2 2 9050 Mesothelioma, malignant 1 0 1 9052 Epithelioid mesothelioma, malignant 1 0 1 9590 Malignant lymphoma, NOS 0 1 1

C37 THYMUS 3 1 4 8000 No histological proof 1 0 1 8580 Thymoma, malignant, NOS 1 0 1 8585 Thymoma, type, malignant 1 0 1 8586 Thymic carcinoma, NOS 0 1 1

C38 HEART, MEDIASTINUM AND PLEURA 2 7 9 8000 No histological proof 0 3 3 8070 Squamous cell carcinoma, NOS 0 2 2 8140 Adenocarcinoma, NOS 1 1 2 9085 Mixed germ cell tumor 0 1 1 9680 Malignant lymphoma, large B-cell, diffuse, NOS 1 0 1

C41 BONES, JOINTS AND ARTICULAR CARTILAGE OF OTHER AND 12 15 27 UNSPECIFIED SITES (C40-C41) 8000 No histological proof 4 8 12 8070 Squamous cell carcinoma, NOS 1 2 3 8801 Spindle cell sarcoma 1 0 1

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Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total 8890 Leiomyosarcoma, NOS 1 0 1 9180 Osteosarcoma, NOS 1 3 4 9186 Central osteosarcoma 0 1 1 9260 Ewing sarcoma 3 1 4 9370 Chordoma, NOS 1 0 1

C42 HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS 63 100 163 8000 No histological proof 7 6 13 9591 Malignant lymphoma, non - Hodgkin, NOS 0 1 1 9680 Malignant lymphoma, large B-cell, diffuse, NOS 0 1 1 9699 Marginal zone B-cell lymphoma, NOS 0 1 1 9732 Multiple myeloma 16 14 30 9733 Plasma cell leukemia 1 0 1 9800 Leukemia, NOS 2 6 8 9801 Acute leukemia, NOS 3 8 11 9820 Lymphoid leukemia, NOS 0 1 1 9823 B-cell chronic lymphocytic leukemia 5 4 9 9826 Burkitt cell leukemia 0 3 3 9835 Precursor cell lymphoblastic leukemia, NOS 4 7 11 9836 Precursor B -cell lymphoblastic leukemia 2 0 2 9860 Myeloid leukemia, NOS 1 2 3 9861 Acute myeloid leukemia, NOS 11 22 33 9863 Chronic myeloid leukemia, NOS 2 8 10 9866 Acute promyelocytic leukemia 0 1 1 9874 Acute myeloid leukemia with maturation 2 0 2 9950 Polycythemia vera 3 3 6 9960 Chronic myeloproliferative disease, NOS 0 2 2 9962 Essential thrombocythemia 0 1 1 9964 Hypereosinophilic syndrome 0 1 1 9980 Refractory anemia 0 1 1 9989 Myelodysplastic syndrome, NOS 4 7 11

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Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total C44 SKIN 45 40 85 8000 No histological proof 1 1 2 8004 Malignant tumor, spindle cell type 0 1 1 8010 Carcinoma, NOS 1 0 1 8051 Verrucous carcinoma, NOS 0 2 2 8070 Squamous cell carcinoma, NOS 8 17 25 8090 Basal cell carcinoma, NOS 23 9 32 8094 Basosquamous carcinoma 1 0 1 8097 Basal cell carcinoma, nodular 3 0 3 8147 Basal cell adenocarcinoma 0 1 1 8401 Apocrine adenocarcinoma 0 1 1 8410 Sebaceous adenocarcinoma 0 1 1 8720 Malignant melanoma, NOS 2 5 7 8800 Sarcoma, NOS 0 1 1 8830 Malignant fibrous histiocytoma 1 0 1 8832 Dematofibrosarcoma, NOS 2 1 3 9700 Mycosis fungoides 2 0 2 9709 Cutaneous T-cell lymphoma, NOS 1 0 1

C47 PERIPHERAL NERVES AND AUTONOMIC NERVOUS SYSTEM 1 2 3 OF HEAD, FACE, AND NECK 9364 Peripheral neuroectodermal tumor 1 0 1 9540 Malignant peripheral nerve sheath tumor 0 1 1 9680 Malignant lymphoma, large B-cell, diffuse, NOS 0 1 1

C48 RETROPERITONEUM AND PERITONEUM 2 3 5 8000 No histological proof 1 1 2 8140 Adenocarcinoma, NOS 0 1 1 8290 Oxyphilic adenocarcinoma 1 0 1 8811 Fibromyxosarcoma 0 1 1

C49 CONNECTIVE, SUBCUTANEOUS AND OTHER SOFT TISSUES 13 17 30 8000 No histological proof 0 1 1

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Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total 8032 Spindle cell carcinoma, NOS 1 0 1 8800 Sarcoma, NOS 3 2 5 8801 Spindle cell sarcoma 1 1 2 8802 Giant cell sarcoma 2 0 2 8805 Undifferentiated sarcoma 1 0 1 8811 Fibromyxosarcoma 0 2 2 8830 Malignant fibrous histiocytoma 1 0 1 8850 Liposarcoma, NOS 0 1 1 8851 Liposarcoma, well-differentiated 1 1 2 8852 Myxoid liposarcoma 0 1 1 8858 Dedifferentiated liposarcoma 0 1 1 8890 Leiomyosarcoma, NOS 1 1 2 8900 Rhabdomyosarcoma, NOS 0 1 1 8982 Malignant myoepithelioma 0 1 1 9040 Synovial sarcoma, NOS 2 1 3 9080 Teratoma, malignant, NOS 0 1 1 9140 Kaposi sarcoma 0 1 1 9540 Malignant peripheral nerve sheath tumor 0 1 1

C50 BREAST 480 3 483 8000 No histological proof 39 0 39 8010 Carcinoma, NOS 4 0 4 8022 Pleomorphic carcinoma 1 0 1 8050 Papillary carcinoma, NOS 2 0 2 8070 Squamous cell carcinoma, NOS 1 0 1 8140 Adenocarcinoma, NOS 6 0 6 8230 Solid carcinoma, NOS 1 0 1 8310 Clear cell adenocarcinoma, NOS 1 0 1 8480 Mucinous adenocarcinoma 5 0 5 8500 Infiltrating duct carcinoma, NOS 395 3 398 8501 Comedocarcinoma, NOS 1 0 1 8503 Intraductal papillary adenocarcinoma 4 0 4 8510 Medullary carcinoma, NOS 1 0 1

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Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total 8520 Lobular carcinoma, NOS 8 0 8 8522 Infiltrating duct and lobular carcinoma 2 0 2 8523 Infiltrating duct mixed with other types of carcinoma 2 0 2 8540 Paget disease, mammary 1 0 1 8541 Paget disease and infiltrating duct carcinoma of the breast 1 0 1 8543 Paget disease and intraductal carcinoma of the breast 1 0 1 8575 Metaplastic carcinoma, NOS 2 0 2 8800 Sarcoma, NOS 1 0 1 9020 Phyllodes tumor, malignant 1 0 1

C51 VULVA 4 0 4 8000 No histological proof 1 0 1 8070 Squamous cell carcinoma, NOS 3 0 3

C52 VAGINA 3 0 3 8010 Carcinoma, NOS 1 0 1 8070 Squamous cell carcinoma, NOS 1 0 1 8140 Adenocarcinoma, NOS 1 0 1

C53 CERVIX UTERI 228 0 228 8000 No histological proof 23 0 23 8010 Carcinoma, NOS 6 0 6 8052 Papillary squamous cell carcinoma 6 0 6 8070 Squamous cell carcinoma, NOS 39 0 39 8071 Squamous cell carcinoma, keratinizing, NOS 19 0 19 8072 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 82 0 82 8073 Squamous cell carcinoma, small, nonkeratinizing 1 0 1 8076 Squamous cell carcinoma, microinvasive 1 0 1 8140 Adenocarcinoma, NOS 24 0 24 8246 Neuroendocrine carcinoma, NOS 2 0 2 8260 Papillary adenocarcinoma, NOS 2 0 2 8380 Endometrioid adenocarcinoma, NOS 2 0 2 8384 Adenocarcinoma, endocervical type 16 0 16

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Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total 8482 Mucinous adenocarcinoma, endocervical type 1 0 1 8560 Adenosquamous carcinoma 3 0 3 8806 Desmoplastic small round cell tumor 1 0 1

C54 CORPUS UTERI 72 0 72 8000 No histological proof 5 0 5 8010 Carcinoma, NOS 1 0 1 8041 Small cell carcinoma, NOS 1 0 1 8140 Adenocarcinoma, NOS 7 0 7 8310 Clear cell adenocarcinoma, NOS 1 0 1

8380 Endometrioid adenocarcinoma, NOS 49 0 49 8381 Endometrioid adenofibroma, malignant 1 0 1 8384 Adenocarcinoma, endocervical type 1 0 1 8441 Serous cystadenocarcinoma, NOS 2 0 2 8470 Mucinous cystadenocarcinoma, NOS 1 0 1 8560 Adenosquamous carcinoma 1 0 1 8900 Rhabdomyosarcoma, NOS 1 0 1 8950 Mullerian mixed tumor 1 0 1

C55 UTERUS 9 0 9 8000 No histological proof 2 0 2 8004 Malignant tumor, spindle cell type 1 0 1 8140 Adenocarcinoma, NOS 2 0 2 8380 Endometrioid adenocarcinoma, NOS 4 0 4

C56 OVARY 91 0 91 8000 No histological proof 26 0 26 8005 Malignant tumor, clear cell type 1 0 1 8010 Carcinoma, NOS 3 0 3 8140 Adenocarcinoma, NOS 13 0 13 8260 Papillary adenocarcinoma, NOS 1 0 1 8310 Clear cell adenocarcinoma, NOS 7 0 7

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Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total 8380 Endometrioid adenocarcinoma, NOS 7 0 7 8440 Cystadenocarcinoma, NOS 1 0 1 8441 Serous cystadenocarcinoma, NOS 9 0 9 8450 Papillary cystadenocarcinoma, NOS 1 0 1 8460 Papillary serous cystadenocarcinoma 1 0 1 8470 Mucinous cystadenocarcinoma, NOS 9 0 9 8480 Mucinous adenocarcinoma 3 0 3 8481 Mucin-producing adenocarcinoma 1 0 1 8620 Granulosa cell tumor, malignant 1 0 1 8980 Carcinosarcoma, NOS 1 0 1 9014 Serous adenocarcinofibroma 1 0 1 9064 Germinoma 1 0 1 9080 Teratoma, malignant, NOS 3 0 3 9084 Teratoma with malignant transformation 1 0 1

C57 FEMALE GENITAL ORGANS 3 0 3 8010 Carcinoma, NOS 1 0 1 8380 Endometrioid adenocarcinoma, NOS 1 0 1 8441 Serous cystadenocarcinoma, NOS 1 0 1

C58 PLACENTA 1 0 1 9100 Choriocarcinoma, NOS 1 0 1

C60 PENIS 0 15 15 8051 Verrucous carcinoma, NOS 0 2 2 8070 Squamous cell carcinoma, NOS 0 13 13

C61 PROSTATE GLAND 0 83 83 8000 No histological proof 0 19 19 8010 Carcinoma, NOS 0 3 3 8130 Papillary transitional cell carcinoma 0 1 1 8140 Adenocarcinoma, NOS 0 59 59 8480 Mucinous adenocarcinoma 0 1 1

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Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total C62 TESTIS 0 7 7 8806 Desmoplastic small round cell tumor 0 1 1 8858 Dedifferentiated liposarcoma 0 1 1 9061 Seminoma, NOS 0 4 4 9070 Embryonal carcinoma, NOS 0 1 1

C64 KIDNEY 9 16 25 8000 No histological proof 3 3 6 8010 Carcinoma, NOS 1 0 1 8130 Papillary transitional cell carcinoma 1 0 1 8240 Carcinoid tumor, NOS 1 0 1 8310 Clear cell adenocarcinoma, NOS 1 4 5 8312 Renal cell carcinoma, NOS 1 8 9 8318 Renal cell carcinoma, sarcomatoid 0 1 1 8960 Nephroblastoma, NOS 1 0 1

C65 RENAL PELVIS 2 2 4 8000 No histological proof 0 1 1 8130 Papillary transitional cell carcinoma 2 1 3

C66 URETER 1 0 1 8120 Transitional cell carcinoma, NOS 1 0 1

C67 BLADDER 21 61 82 8000 No histological proof 4 1 5 8010 Carcinoma, NOS 2 0 2 8070 Squamous cell carcinoma, NOS 0 1 1 8120 Transitional cell carcinoma, NOS 9 31 40 8130 Papillary transitional cell carcinoma 6 23 29 8140 Adenocarcinoma, NOS 0 3 3 8806 Desmoplastic small round cell tumor 0 1 1 9680 Malignant lymphoma, large B-cell, diffuse, NOS 0 1 1

3018 || PP a a g ge e

Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total C69 EYE AND ADNEXA 1 1 2 8000 No histological proof 0 1 1 9510 Retinoblastoma, NOS 1 0 1

C70 MENINGER 4 1 5 9530 Meningioma, malignant 3 0 3 9539 Meningeal sacomatosis 1 1 2

C71 BRAIN 18 25 43 8000 No histological proof 8 10 18 8004 Malignant tumor, spindle cell type 1 0 1 8010 Carcinoma, NOS 0 1 1 9400 Astrocytoma, NOS 0 2 2 9401 Astrocytoma, anaplastic 1 0 1 9411 Gemistocytic astrocytoma 0 1 1 9440 Glioblastoma, NOS 4 9 13 9451 Oligodendroglioma, anaplastic 1 0 1 9470 Medulloblastoma, NOS 2 1 3 9500 Neuroblastoma, NOS 1 0 1 9590 Malignant lymphoma, NOS 0 1 1

C72 SPINAL CORD, CRANIAL NERVES AND OTHER PARTS OF 5 3 8 CENTRAL NERVOUS SYSTEM 8000 No histological proof 1 2 3 8806 Desmoplastic small round cell tumor 1 0 1 9380 Glioma, malignant 1 0 1 9391 Ependymoma, NOS 0 1 1 9560 Neurilemoma, malignant 1 0 1 9680 Malignant lymphoma, large B-cell, diffuse, NOS 1 0 1

C73 THYROID GLAND 87 21 108 8000 No histological proof 8 1 9 8010 Carcinoma, NOS 2 0 2

18 | P a g e 31 | P a g e

Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total 8021 Carcinoma, anaplastic, NOS 2 1 3 8050 Papillary carcinoma, NOS 15 2 17 8070 Squamous cell carcinoma, NOS 1 0 1 8260 Papillary adenocarcinoma, NOS 37 10 47 8290 Oxyphilic adenocarcinoma 1 0 1 8330 Follicular adenocarcinoma, NOS 12 5 17 8340 Papillary carcinoma, follicular variant 4 2 6 8341 Papillary microcarcinoma 2 0 2 8350 Nonencapsulated sclerosing carcinoma 1 0 1 8510 Medullary carcinoma, NOS 2 0 2

C74 ADRENAL GLAND 1 3 4 8000 No histological proof 0 1 1 8140 Adenocarcinoma, NOS 0 1 1 8370 Adrenal cortical carcinoma 0 1 1 9500 Neuroblastoma, NOS 1 0 1

C75 OTHER ENDOCRINE GLANDS AND RELATED 1 1 2 9064 Germinoma 1 1 2

C76 OTHER AND ILL-DEFINED SITES 1 2 3 8000 No histological proof 0 1 1 8070 Squamous cell carcinoma, NOS 1 0 1 9680 Malignant lymphoma, large B-cell diffuse, NOS 0 1 1

C77 LYMPH NODES 51 57 108 8000 No histological proof 7 7 14 8589 Carcinoma showing thymus-like element 1 0 1 9590 Malignant lymphoma, NOS 4 8 12 9591 Malignant lymphoma, non - Hodgkin, NOS 9 13 22 9650 Hodgkin lymphoma, NOS 3 1 4 9652 Hodgkin lymphoma, mixed cellularity, NOS 1 0 1 9663 Hodgkin lymphoma, nodular sclerosis, NOS 1 0 1

18 | P a g e 32 | P a g e

Pathology Cancer Incidence in Rayong, Thailand, 2013-2015 Pathology and Sites Male Female Total 9670 Malignant lymphoma, small B lymphocytic, NOS 1 0 1 9673 Mantle cell lymphoma 0 1 1 9675 Malignant lymphoma, mixed small and large cell, diffuse 0 1 1 9680 Malignant lymphoma, large B-cell diffuse, NOS 19 14 33 9684 Malignant lymphoma, large B-cell diffuse, immunoblastic, NOS 0 1 1 9687 Burkitt lymphoma, NOS 0 3 3 9691 Follicular lymphoma, grade 2 1 1 2 9698 Follicular lymphoma, grade 3 0 1 1 9699 Marginal zone B-cell lymphoma, NOS 2 0 2 9702 Mature T-cell lymphoma, NOS 1 3 4 9714 Anaplastic large cell lymphoma, T cell, and Null cell type 1 1 2 9823 B-cell chronic lymphocytic leukemia 0 1 1 9860 Myeloid leukemia, NOS 0 1 1

C80 UNKNOWN PRIMARY SITE 24 46 70 8000 No histological proof 10 21 31 8001 Tumor cells, malignant 0 1 1 8010 Carcinoma, NOS 8 3 11 8020 Carcinoma, undifferentiated, NOS 1 3 4 8070 Squamous cell carcinoma, NOS 1 7 8 8140 Adenocarcinoma, NOS 2 10 12 8481 Mucin-producing adenocarcinoma 1 0 1 8490 Signet ring cell carcinoma 0 1 1 8500 Infiltrating duct carcinoma, NOS 1 0 1

Total 1877 1644 3521

18 | P a g e 33 | P a g e

District Cancer Incidence in Rayong, Thailand, 2013-2015

Table 3.1 Rayong (2014), Mean annual ASR per 100,000 (2013 – 2015) by District – Male

No. District Code District Crude rate ASR 1 2103 Klaeng 169.3 131.3 2 2106 Pluak Daeng 114.9 128.2 3 2102 Ban Chang 130.1 128.1 4 2101 Mueang Rayong 125.3 127.2 5 2107 Khao Chamao 132.3 116.2 6 2105 Ban Khai 138.8 109.9 7 2104 Wang Chan 132.1 108.5 8 2108 Nikhom Patthana 103.3 103.3 All of the province 132.6 131.6

Figure 3.1 Mean annual incidence in Rayong (2013 – 2015), Male

Very incidence Medium incidence Less incidence

34 | P a g e

Districts Cancer Incidence in Rayong, Thailand, 2013-2015

Table 3.2 Rayong (2014), Mean annual ASR per 100,000 (2013 – 2015)

by District – Female

No. District Code District Crude rate ASR 1 2103 Klaeng 204.3 146.4 2 2102 Ban Chang 172.1 144.2 3 2106 Pluak Daeng 139.8 126.4 4 2101 Mueang Rayong 146.0 122.7 5 2104 Wang Chan 149.6 115.5 6 2108 Nikhom Patthana 123.5 107.7 7 2105 Ban Khai 132.3 95.6 8 2107 Khao Chamao 92.1 71.9 All of the province 153.3 125.9

Figure 3.2 Mean annual incidence in Rayong (2013 – 2015), female

Very incidence Medium incidence Less incidence

35| P a g e

District : Muang Rayong Cancer Incidence in Rayong, Thailand, 2013-2015

Muang Rayong District Incidence During the period 2013-2015, there were 1,400 incident cases of new cancer in Muang Rayong district residents, 648 among males and 752 among females. The average age-standardized incidence rate was 127.2 per 100,000 population among males and 122.7 among females.

Leading Cancers Lung cancer was the most common cancer (ASR = 22.2 per 100,000 population) followed by liver cancer 15.5, colorectal cancer 16.1, prostate cancer 8.0, and esophageal cancer 6.3 among males (Table 4.1). Breast cancer was the most common cancer (ASR = 31.2 per 100,000 population) followed by cervical cancer 13.0, lung cancer 12.8, colorectal cancer 11.5, and liver cancer 5.9 among females (Table 4.2).

Figure 4.1 Population pyramid in Muang Rayong District, Rayong estimated population in 2014 (average 2013-2015)

3,597 75+ 5,378 2,693 70- 74 3,331 3,724 65- 69 4,540 5,580 60-64 6,477 7,448 55-59 8,300 10,890 50-54 11,327

14,087 45-49 13,957 16,794 40-44 15,808 16,752 35-39 16,144 14,413 30-34 14,692

11,735 25-29 11,820 11,952 20-24 11,526 13,162 15-19 12,384 12,931 10-14 11,808 13,743 5-9 12,529 12,838 0-4 11,684 18000 16000 14000 12000 10000 8000 6000 4000 2000 0 0 2000 4000 6000 8000 10000 12000 14000 16000 MALE FEMALE

36 | P a g e

Districts : Muang Rayong Cancer Incidence in Rayong, Thailand, 2013-2015

Table 4.1 Leading cancer in Muang Rayong District, Rayong (Male) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Trachea, Bronchus, and lung 37 21.3 22.2 2 Liver and bile duct 27 15.9 15.5 3 Colon and rectum 26 15.3 16.1 4 Prostate 12 6.8 8.0 5 Oesophagus 10 6.0 6.3 All Sites 216 125.3 127.2

Table 4.2 Leading cancer in Muang Rayong District, Rayong (Female) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Breast 68 39.4 31.2 2 Cervix uteri 27 15.9 13.0 3 Trachea, Bronchus, and lung 26 14.9 12.8 4 Colon and Rectum 23 13.4 11.5 5 Liver and bile duct 12 6.8 5.9 All Sites 251 146.0 122.7

37 | P a g e

Districts : Muang Rayong Cancer Incidence in Rayong, Thailand, 2013-2015

Figure 4.2 Leading cancer in Muang Rayong District, Rayong (mean annual ASR 2013-2015)

ASR (World)

38 | P a g e

Districts : Muang Rayong Cancer Incidence in Rayong, Thailand, 2013-2015

0.7

0.2

0.3

0.1

0.0

0.3

0.0

0.1

0.3

0.0

0.7

0.0

0.2

0.0

1.3

0.2

0.0

0.2

0.4

0.0

0.1

0.0

2.7

0.3

0.1

1.9

0.1

1.0

1.2

0.0

0.5

0.0

0.2

0.3

0.0

0.2

0.1

0.2

0.1

0.8

- 15.6 0 Rate

7.2

0.3

0.1

0.2

0.1

0.0

0.3

0.0

0.1

0.2

0.0

0.3

0.0

0.1

0.0

0.2

0.1

0.0

0.1

0.0

0.1

0.0

1.3

0.1

0.0

1.1

0.0

0.4

0.3

0.0

0.2

0.4

0.0

0.1

0.3

0.0

0.2

0.1

0.0

0.1

0.0

- 0

Cum

ALL

C95

C91

C90

C74

C73

C69

C67

C65

C64

C62

C61

C60

C57

C56

C55

C54

C53

C51

C50

C44

C43

C32

C25

C23

C21

C17

C16

C15

C14

C11

C10

C09

C00

C81

C18

O&U

ICD-10

C92-94

C70-72

C33-34

C30-31

C19-20

C12-13

C03-06

C01-02

C37-38

C07-08

C47,C49

C22,C24

D45-D47

C40-C41

C82-85,C96

5.1

1.7

1.6

0.3

4.1

0.2

0.4

1.2

0.3

5.7

0.1

1.7

0.4

1.5

0.0

0.2

0.3

1.3

0.3

2.3

0.4

0.9

0.5

0.7

7.2

0.4

3.9

6.3

0.3

1.5

2.9

0.4

2.4

1.0

0.5

2.0

0.2

2.8

8.0

1.8

3.8

8.3

22.2

15.5

127.2

ASRWorld

1.5

1.4

3.1

1.4

0.4

4.6

0.2

0.4

1.4

3.1

0.2

5.2

0.2

1.5

0.6

1.5

0.0

0.2

1.9

3.7

0.4

1.4

0.4

2.1

0.4

1.2

0.4

0.6

7.0

7.7

0.6

3.9

6.0

0.4

1.5

3.5

0.4

2.7

1.0

0.4

2.1

0.2

4.8

6.8

21.3

15.9

Male

125.3

CrudeRate

9.3

0.0

9.3

0.0

9.3

0.0

9.3

0.0

9.3

0.0

9.3

0.0

9.3

0.0

9.3

0.0

75+

46.3

55.6

64.9

55.6

18.5

83.4

27.8

18.5

27.8

18.5

194.6

843.3

0.0

70-

49.5

12.4

37.1

12.4

49.5

12.4

99.0

61.9

12.4

24.8

86.6

24.8

965.5

136.2

173.3

9.0

0.0

9.0

0.0

9.0

0.0

9.0

0.0

9.0

0.0

65-

26.9

17.9

71.6

26.9

53.7

17.9

44.8

80.6

716.2

116.4

107.4

6.0

0.0

6.0

0.0

6.0

0.0

6.0

0.0

6.0

0.0

6.0

0.0

60-

17.9

11.9

29.9

11.9

65.7

23.9

29.9

17.9

35.8

41.8

466.0

107.5

2015) by Age Group 2015)Age by

0.0

4.5

0.0

9.0

0.0

4.5

0.0

9.0

0.0

4.5

9.0

0.0

4.5

9.0

0.0

4.5

0.0

55-

22.4

13.4

71.6

94.0

26.9

13.4

389.4

–

3 3

9.2

3.1

0.0

9.2

0.0

3.1

0.0

6.1

0.0

3.1

0.0

6.1

9.2

0.0

6.1

3.1

0.0

3.1

6.1

0.0

9.2

0.0

3.1

6.1

9.2

0.0

9.2

0.0

3.1

0.0

50-

24.5

27.5

18.4

39.8

235.7

0.0

2.4

0.0

2.4

0.0

2.4

0.0

2.4

0.0

2.4

0.0

4.7

0.0

2.4

0.0

2.4

0.0

2.4

0.0

9.5

0.0

4.7

2.4

0.0

2.4

9.5

0.0

7.1

2.4

0.0

45-

94.7

18.9

6.0

0.0

2.0

0.0

4.0

0.0

2.0

0.0

2.0

0.0

2.0

0.0

4.0

0.0

4.0

0.0

6.0

7.9

4.0

2.0

0.0

4.0

0.0

4.0

0.0

40-

17.9

81.4

0.0

2.0

0.0

4.0

0.0

2.0

0.0

2.0

0.0

2.0

0.0

2.0

0.0

2.0

0.0

6.0

0.0

4.0

0.0

2.0

4.0

0.0

2.0

0.0

2.0

0.0

8.0

35-

59.7

11.9

0.0

4.6

0.0

6.9

0.0

2.3

0.0

2.3

0.0

4.6

0.0

6.9

0.0

2.3

0.0

4.6

0.0

4.6

0.0

30-

39.3

0.0

2.8

25-

17.0

0.0

5.6

0.0

2.8

20-

22.3

5.1

0.0

2.5

0.0

2.5

0.0

15-

0.0

2.6

7.7

0.0

2.6

0.0

10-

12.9

7.3

0.0

2.4

0.0

2.4

0.0

2.4

0.0

2.6

0.0

5.2

0.0

2.6

0.0

(2014), Mean annual ASR per 100,000 (20 ASR (2014), 100,000 per annual Mean

13.0

216

Year

No.Case

Muang Rayong Muang

4.3

Table Table

Allsites

Otherunspecified and

Myelodysplasticdisease

Leukemia unspecified Leukemia

Myeloidleukemia

Lymphoidleukemia

Multiplemyeloma

Non-Hodgkinlymphoma

Hodgkindisease

Adrenalgland

Thyroid

Brain,nervous system

Eye

Bladder

Renalpelvis

Kidney

Testis

Prostate

Penis

Otherfemale organs genital

Ovary

Uterusunspecified

Corpusuteri

Cervixuteri

Vulva

Breast

Connectivetissue

Otherskin

Melanomaof skin

Bone

Otherorgans thoracic

Trachea, Bronchus and lung and Bronchus Trachea,

Larynx

Nose,etc. sinuses

Pancreas

Gallbladder

Liverbile and duct

Anus

Rectum

Colon

Smallintestine

Stomach

Oesophagus

Pharynx unspecified Pharynx

Hypopharynx

Nasopharynx

Otheroropharynx

Tonsil

Salivaryglands

Mouth

Tongue

Lip Site

39 | P a g e

Districts : Muang Rayong Cancer Incidence in Rayong, Thailand, 2013-2015

0.3

0.1

0.0

0.1

0.4

0.0

0.6

0.1

0.0

0.2

0.1

0.0

0.6

0.1

0.7

1.4

0.0

3.4

0.2

0.0

1.6

0.1

0.0

0.2

0.0

0.7

0.1

0.6

0.9

0.0

0.3

0.1

0.0

0.1

0.0

0.2

0.1

13.7 0

Rate

0.2

0.1

0.0

0.1

0.0

0.4

0.1

0.0

0.1

0.0

0.5

0.1

0.4

1.0

0.0

2.4

0.2

0.0

0.6

0.0

0.1

0.0

0.3

0.0

0.2

0.4

0.0

0.2

0.1

0.0

0.1

0.0

0.1

0.0

8.2 -

0 Cum

ALL

C95

C91

C90

C74

C73

C69

C67

C65

C64

C62

C61

C60

C57

C56

C55

C54

C53

C51

C50

C44

C43

C32

C25

C23

C21

C17

C16

C15

C14

C11

C10

C09

C00

C81 C18

O&U

ICD-10

C92-94

C70-72

C33-34

C30-31

C19-20

C12-13

C03-06

C01-02

C37-38

C07-08

C47,C49

C22,C24 D45-D47 C40-C41

C82-85,C96

2.9

0.5

0.2

0.6

1.5

1.2

2.7

0.6

0.0

5.5

1.7

0.3

1.9

0.4

0.5

0.0

0.4

5.4

5.5

0.1

1.7

2.0

0.3

0.6

0.2

0.4

0.1

1.3

0.6

5.9

0.4

3.7

7.3

0.3

2.5

1.2

0.0

1.3

0.0

0.3

1.1

1.0

0.4

0.8

13.0

31.2 12.8 ale 122.7

ASRWorld Fem

3.5

0.6

0.2

0.6

1.4

2.7

0.6

0.0

6.2

1.6

0.2

2.3

0.4

0.0

0.6

6.4

1.0

6.4

0.2

1.9

2.7

0.4

0.2

0.6

0.2

1.6

1.0

0.4

4.1

0.4

2.9

1.4

0.0

1.7

0.0

0.4

1.2

0.6

0.8

6.8

8.9

15.9

39.4 14.9

146.0

CrudeRate

0.0

6.2

0.0

6.2

0.0

6.2

75+

37.2

12.4

43.4

49.6

12.4

31.0

49.6

12.4

62.0

12.4

24.8

18.6 18.6

607.4 117.8

0.0

70-

20.0

30.0

20.0

30.0

20.0

70.0

20.0

10.0

20.0

50.0 10.0

10.0

80.0 600.3 130.1

0.0

7.3

0.0

7.3

0.0

7.3

0.0

7.3

0.0

7.3

0.0

65-

14.7

22.0

14.7

22.0

44.1

51.4

29.4

14.7

80.8 499.3 124.8

5.1

0.0

5.1

0.0

5.1

0.0

5.1

0.0

5.1

0.0

5.1

0.0

5.1

0.0

5.1

0.0

60-

15.4

20.6

30.9

56.6

66.9

15.4

46.3

25.7

15.4

25.7 15.4

15.4

422.0 2015) by Age Group 2015)Age by

–

0.0

4.0

0.0

4.0

0.0

4.0

0.0

4.0

0.0

4.0

0.0

4.0

0.0

4.0

0.0

8.0

8.0 8.0

55-

12.0

24.1

20.1

24.1

20.1

24.1

28.1

84.3 3 3 321.3

2.9

0.0

5.9

0.0

2.9

0.0

5.9

0.0

2.9

0.0

5.9

0.0

2.9

0.0

2.9

0.0

5.9

0.0

5.9

2.9

0.0

5.9

0.0

2.9

0.0

50-

8.8

14.7

11.8

61.8 294.3 114.8

2.4

0.0

2.4

0.0

9.6

0.0

2.4

0.0

2.4

0.0

9.6

0.0

2.4

9.6

0.0

2.4

0.0

2.4

0.0

4.8

45-

16.7

31.0

93.1 14.3 14.3

243.6

0.0

2.1

0.0

2.1

0.0

6.3

0.0

2.1

0.0

2.1

0.0

6.3

4.2

2.1

0.0

2.1

0.0

0.0 8.4

40-

59.0

19.0 14.8 130.7

0.0

6.2

0.0

6.2

0.0

2.1

0.0

2.1

0.0

2.1

0.0

6.2

0.0

2.1

0.0

35-

95.0 20.6 43.4

2.3

0.0

2.3

0.0

2.3

0.0

2.3

0.0

2.3

0.0

4.5

0.0

2.3

0.0

4.5

0.0

2.3

0.0

2.3

0.0

30- 47.6 18.2

0.0

5.6

0.0

2.8

8.5

2.8 2.8

25- 33.8

0.0

2.9

0.0

2.9

0.0

2.9

0.0

2.9

0.0 8.7 20- 20.2

2.7

0.0

2.7

0.0

2.7

0.0

2.7

0.0

2.7

0.0

0.0 15-

18.8

0.0

2.8 2.8 10-

0.0

2.7

0.0

2.7

0.0

2.7

0.0

0.0 0.0 8.0

0.0

2.9

0.0

2.9

0.0

0.0 0.0 8.6

68 251

Year

Rayong (2014), Mean annual ASR (20 100,000 per annual (2014), Rayong Mean No.Case

Muang Muang

4 . 4

Allsites

Otherunspecified and

Myelodysplasticdisease

Leukemia unspecified Leukemia

Myeloidleukemia

Lymphoidleukemia

Multiplemyeloma

Non-Hodgkinlymphoma

Hodgkindisease

Adrenalgland

Thyroid

Brain,nervous system

Eye

Bladder

Renalpelvis

Kidney

Testis

Prostate

Penis

Otherfemale organs genital

Ovary

Uterusunspecified

Corpusuteri

Cervixuteri

Vulva

Breast

Connectivetissue

Otherskin

Melanomaof skin

Bone

Otherorgans thoracic

Trachea, Bronchus and lung and Bronchus Trachea,

Larynx

Nose,etc. sinuses

Pancreas

Gallbladder

Liverbile and duct

Anus

Rectum

Colon

Smallintestine

Stomach

Oesophagus

Pharynx unspecified Pharynx

Hypopharynx

Nasopharynx

Otheroropharynx

Tonsil

Salivaryglands

Mouth

Tongue

Lip Site

Table Table

40 | P a g e

Districts : Ban Chang Cancer Incidence in Rayong, Thailand, 2013-2015

Ban Chang District Incidence During the period 2013-2015, there were 368 incident cases of new cancer in Ban Chang district residents, 162 among males and 206 among females. The average age-standardized incidence rate was 128.1 per 100,000 population among males and 144.2 among females.

Leading Cancers Lung cancer was the most common cancer (ASR = 28.5 per 100,000 population) followed by colorectal cancer 16.2, liver cancer 14.9, nasopharyngeal cancer 6.0, and esophageal cancer 5.7 among males (Table 5.1). Breast cancer was the most common cancer (ASR = 38.6 per 100,000 population) followed by cervical cancer 16.8, liver cancer 17.1, colorectal cancer 12.9, and lung cancer 12.7 among females (Table 5.2).

Figure 5.1 Population pyramid in Ban Chang district, Rayong estimated population in 2014 (average 2013-2015)

1,002 75+ 1,264 679 70- 74 739 884 65-69 1,206 1,256 60-64 1,433 1,778 55-59 1,794 2,747 50-54 2,629

3,542 45-49 3,404 4,048 40-44 3,808

4,000 35-39 3,887 3,417 30-34 3,306

2,754 25-29 2,707

3,245 20-24 2,686 3,044 2,842 15-19 2,847 10-14 2,597 3,224 5-9 2,895 3,038 2,691 0-4 4500 4000 3500 3000 2500 2000 1500 1000 500 0 0 500 1000 1500 2000 2500 3000 3500 4000 MALE FEMALE

41 | P a g e

District : Ban Chaang Cancer Incidence in Rayong, Thailand, 2013-2015

Table 5.1 Leading cancer in Ban Chang District, Rayong (Male) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Trachea, Bronchus, and lung 12 28.9 28.5 2 Colon and Rectum 7 16.9 16.2 3 Liver and bile duct 6 15.3 14.9 4 Nasopharynx 3 6.4 6.0 5 Oesophagus 2 5.6 5.7 All Sites 54 130.1 128.1

Table 5.2 Leading cancer in Ban Chang District, Rayong (Female) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Breast 19 47.6 38.6 2 Liver and bile duct 7 17.5 17.1 3 Cervix uteri 9 22.6 16.8 4 Colon and Rectum 7 16.7 12.9 5 Trachea, Bronchus, and lung 6 14.2 12.7 All Sites 69 172.1 144.2

42| P a g e

Districts : Ban Chang Cancer Incidence in Rayong, Thailand, 2013-2015

Figure 5.2 Leading cancer in Ban Chang District, Rayong (mean annual ASR 2013-2015)

ASR (World)

43 | P a g e

District : Ban Chaang Cancer Incidence in Rayong, Thailand, 2013-2015

0.6

0.0

0.1

0.3

0.2

0.0

0.3

0.1

0.6

0.0

0.1

0.3

0.0

0.1

0.0

3.7

0.2

0.0

0.2

2.1

0.0

0.4

1.2

0.1

0.7

0.1

0.5

0.2

0.0

0.2

0.0

0.1

0.8

13.9

Rate

7.6

0.2

0.0

0.1

0.3

0.2

0.0

0.3

0.1

0.2

0.1

0.0

0.1

0.0

0.1

0.0

1.6

0.2

0.0

0.1

0.0

0.4

0.6

0.1

0.5

0.1

0.5

0.2

0.0

0.2

0.0

0.1

0.8

Cum

ALL

C95

C91

C90

C73

C67

C64

C62

C61

C60

C56

C54

C53

C50

C44

C43

C32

C25

C23

C21

C16

C15

C11

C10

C09

C18

O&U

ICD-10

C92-94

C70-72

C33-34

C30-31

C19-20

C12-13

C03-06

C01-02

C37-38

C07-08

C47,C49

C22,C24

D45-D47

C40-C41

C82-85,C96

5.2

0.0

1.9

3.3

3.9

0.0

3.4

1.3

6.2

0.7

1.4

0.5

0.0

1.1

2.3

2.4

0.7

1.7

0.0

1.6

0.0

2.4

1.1

0.0

4.3

1.4

5.7

1.1

6.0

1.5

0.5

1.9

1.2

1.0

5.8

14.9

12.0

28.5

128.1

ASRWorld

5.6

0.0

1.6

3.2

2.4

0.0

4.0

1.6

5.6

1.6

5.6

0.0

1.6

2.4

1.6

0.0

1.6

0.0

2.4

0.0

1.6

5.6

6.4

1.6

2.4

1.6

0.8

4.8

0.8

15.3

12.0

28.9

130.1

Male

CrudeRate

0.0

75+

66.6

33.3

66.6

33.3

133.1

266.2

166.4

998.3

0.0

70-

49.1

343.5

147.2

687.1

0.0

65-

37.7

75.5

37.7

75.5

37.7

75.5

37.7

565.9

113.2

0.0

60-

26.5

53.1

26.5

53.1

424.7

132.7

0.0

55-

93.7

56.2

37.5

56.2

37.5

18.7

431.2

2015) by Age Group 2015)Group Age by

–

0.0

50-

24.3

12.1

36.4

12.1

36.4

24.3

12.1

24.3

242.7

3 3

0.0

9.4

0.0

9.4

0.0

9.4

0.0

9.4

0.0

9.4

0.0

9.4

0.0

9.4

0.0

45-

28.2

122.3

(20

0.0

8.2

40-

74.1

16.5

0.0

8.3

35-

50.0

16.7

0.0

9.8

30-

19.5

0.0

25-

12.1

48.4

0.0

20-

20.5

10.3

0.0

15-

21.9

11.0

0.0

10-

11.7

0.0

54.9

11.0

32.9

11.0

(2014), Mean annual ASR (2014),100,000per annual Mean

Year

No.Case

BanChang

5.3

Allsites

Otherunspecified and

Myelodysplasticdisease

Leukemia unspecified Leukemia

Myeloidleukemia

Lymphoidleukemia

Multiplemyeloma

Non-Hodgkinlymphoma

Thyroid

Brain,nervous system

Bladder

Kidney

Testis

Prostate

Penis

Ovary

Corpusuteri

Cervixuteri

Breast

Connectivetissue

Otherskin

Melanomaof skin

Bone

Otherorgans thoracic

Trachea, Bronchus and lung and Bronchus Trachea,

Larynx

Nose,etc. sinuses

Pancreas

Gallbladder

Liverbile and duct

Anus

Rectum

Colon

Stomach

Oesophagus

Hypopharynx

Nasopharynx

Otheroropharynx

Tonsil

Salivaryglands

Mouth

Tongue

Site Table Table

44 | P a g e

Districts : Ban Chang Cancer Incidence in Rayong, Thailand, 2013-2015

0.7

0.0

0.1

0.2

0.1

0.3

0.4

0.2

0.1

0.0

0.6

0.7

1.6

4.0

0.0

0.2

0.0

0.1

1.6

0.0

0.2

0.0

2.4

0.1

0.3

1.1

0.1

0.0

0.2

0.0

0.1

0.0

15.9 0 Rate

0.0

0.1

0.2

0.1

0.3

0.2

0.1

0.0

0.4

1.6

3.1

0.0

0.1

0.0

0.1

1.0

0.0

1.0

0.1

0.3

0.6

0.1

0.0

0.2

0.0

0.1

0.0

- 10.4

0 Cum

ALL

C95

C91

C90

C73

C67

C64

C62

C61

C60

C56

C54

C53

C50

C44

C43

C32

C25

C23

C21

C16

C15

C11

C10

C09 C18

O&U

ICD-10

C92-94

C70-72

C33-34

C30-31

C19-20

C12-13

C03-06

C01-02

C37-38

C07-08

C47,C49

C22,C24 D45-D47 C40-C41

C82-85,C96

4.5

1.1

1.5

1.0

0.6

1.7

1.1

4.3

4.0

2.6

0.0

5.7

6.1

0.5

2.1

0.0

0.7

0.0

0.9

0.5

0.0

0.6

2.4

9.9

1.2

1.5

0.0

2.0

0.0

0.7

0.0

0.0 0.8

0.8

12.7

17.1

16.8 38.6 144.2

ASRWorld

5.0

1.7

4.2

3.3

0.0

7.5

2.5

0.0

2.5

1.7

0.0

2.5

0.0

0.8

0.8 0.8

ale

22.6

47.6

14.2

17.5 13.4 172.1

CrudeRate Fem

0.0

0.0 0.0

0.0

75+

26.4

52.7

26.4

52.7

26.4

52.7

26.4

79.1

26.4

79.1

79.1 26.4 579.9

0.0

70-

45.1

90.2

45.1

90.2 676.4 225.5

0.0

65-

27.6

27.6 55.3

82.9 414.7 138.2

0.0

60-

23.3

46.5

23.3

46.5

23.3

69.8

139.5 116.3 488.4

0.0

55-

37.2

18.6

18.6 18.6

18.6

464.4 111.5

167.2

2015) by Age Group 2015)Group Age by

0.0

0.0 0.0

50-

12.7

25.4

12.7

50.7

12.7

25.4

38.0

– 355.0 114.1

3 3

0.0

9.8

45-

29.4

49.0

19.6 78.3

215.4

0.0

40-

8.8

17.5

52.5 52.5 26.3

201.3

0.0

8.6

8.6 8.6

35-

17.2 60.0 128.6

0.0

30-

10.1

20.2

30.2

10.1 10.1 80.7

0.0

25-

73.9

24.6 12.3 36.9

0.0

0.0 0.0

20- 12.4 12.4

0.0

15- 11.7 11.7

0.0

0.0 0.0

10- 12.8 12.8

0.0

0.0 11.5 11.5

0.0

12.4 12.4

24.8

(2014), Mean annual ASR (20100,000per annual (2014),Mean

69 19

Year

No.Case

Ban Chang Ban

4 .

Allsites

Otherunspecified and

Myelodysplasticdisease

Leukemia unspecified Leukemia

Myeloidleukemia

Lymphoidleukemia

Multiplemyeloma

Non-Hodgkinlymphoma

Thyroid

Brain,nervous system

Bladder

Kidney

Testis

Prostate

Penis

Ovary

Corpusuteri

Cervixuteri

Breast

Connectivetissue

Otherskin

Melanomaof skin

Bone

Otherorgans thoracic

Trachea, Bronchus and lung and Bronchus Trachea,

Larynx

Nose,etc. sinuses

Pancreas

Gallbladder

Liverbile and duct

Anus

Rectum

Colon

Stomach

Oesophagus

Hypopharynx

Nasopharynx

Otheroropharynx

Tonsil

Salivaryglands

Mouth

Tongue

Site Table Table

45 | P a g e

District : Klaeng Cancer Incidence in Rayong, Thailand, 2013-2015

Klaeng District Incidence During the period 2013-2015, there were 768 incident cases of new cancer in Klaeng district residents, 346 among males and 422 among females. The average age-standardized incidence rate was 131.3 per 100,000 population among males and 146.4 among females.

Leading Cancers Liver cancer was the most common cancer (ASR = 24.4 per 100,000 population) followed by lung cancer 15.9, colorectal cancer 13.2, esophageal cancer 7.8, and oral cavity 7.1 among males (Table 6.1). Breast cancer was the most common cancer (ASR = 35.3 per 100,000 population) followed by cervical cancer 19.4, lung cancer 13.2, colorectal cancer 9.9, and ovarian cancer 9.9 among females (Table 6.2).

Figure 6.1 Population pyramid in Klaeng District, Rayong estimated population in 2014 (average 2013-2015)

2,317 75+ 3,243 1,654 70 -74 1,809 2,202 65-69 2,368 2,994 60-64 3,398 3,566 55-59 4,223

4,767 50-54 5,186

5,563 45-49 5,952 5,821 40-44 5,889

5,721 35-39 5,812 5,508 30-34 5,208

4,792 25-29 4,537

4,929 20-24 4,768 5,301 4,799 15-19 4,515 10-14 3,994 4,382 5-9 3,955 4,088 0-4 3,723

6000 5000 4000 3000 2000 1000 0 0 1000 2000 3000 4000 5000 6000 MALE FEMALE

46| P a g e

Districts : Klaeng Cancer Incidence in Rayong, Thailand, 2013-2015

Table 6.1 Leading cancer in Klaeng District, Rayong (Male) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Liver and bile duct 21 31.3 24.4 2 Trachea, Bronchus, and lung 15 21.5 15.9 3 Colon and Rectum 11 16.6 13.2 4 Oesophagus 7 9.8 7.8 5 Oral cavity 7 9.8 7.1 All Sites 115 169.3 131.3

Table 6.2 Leading cancer in Klaeng District, Rayong (Female) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Breast 35 50.8 35.3 2 Cervix uteri 19 27.1 19.4 3 Trachea, Bronchus, and lung 13 19.4 13.2 4 Colon and Rectum 10 14.5 9.9 5 Ovary 9 12.6 9.9 All Sites 141 204.3 146.4

47 | P a g e

District : Klaeng Cancer Incidence in Rayong, Thailand, 2013-2015

Figure 6.2 Leading cancer in Klaeng District, Rayong (mean annual ASR 2013-2015)

ASR (World)

48 | P a g e

Districts : Klaeng Cancer Incidence in Rayong, Thailand, 2013-2015

0.5

0.2

0.0

0.3

0.6

0.0

0.2

0.1

0.4

0.0

0.1

0.0

0.9

0.2

0.0

0.2

0.0

0.2

1.7

0.6

0.0

0.5

0.2

3.0

0.0

0.6

1.1

0.0

0.2

1.0

0.2

0.5

0.1

0.3

0.1

0.3

0.0

15.1 0

Rate

0.5

0.1

0.0

0.1

0.2

0.4

0.0

0.1

0.2

0.0

0.1

0.0

0.2

0.1

0.0

0.1

0.0

0.1

0.7

0.3

0.0

0.3

0.1

2.0

0.0

0.4

0.3

0.0

0.2

0.5

0.1

0.3

0.1

0.2

0.0

0.2

0.3

0.0 8.1

- 0 Cum

ALL

C95

C90

C75

C74

C73

C67

C66

C65

C64

C62

C61

C60

C56

C55

C54

C53

C52

C51

C50

C45

C44

C43

C32

C25

C23

C21

C17

C16

C15

C11

C10

C09

C00

C18 O&U

ICD-10

C92-94

C70-72

C33-34

C30-31

C19-20

C12-13

C03-06

C01-02

C37-38

C07-08

C47,C49

C22,C24 D45-D47 C40-C41

C82-85,C96

5.1

1.9

0.3

2.0

2.1

5.2

0.6

0.4

1.6

1.0

4.3

0.0

0.3

1.1

0.5

6.7

1.2

0.0

1.1

0.0

0.6

0.9

2.0

0.3

3.9

1.1

0.4

0.3

2.1

4.9

0.4

2.6

0.7

2.6

0.0

4.8

8.0

2.8

7.8

3.8 15.9

24.4

131.3

ASRWorld

6.9

2.4

0.5

2.4

6.4

0.5

2.0

1.5

5.4

0.0

0.5

1.5

0.5

1.5

0.0

1.5

0.0

1.0

0.5

1.0

2.0

6.4

0.5

4.9

1.5

0.5

5.9

0.5

3.9

2.9

6.4

0.5

3.4

1.0

3.4

5.4

0.0

9.8

8.8

21.5

31.3

10.3

169.3

CrudeRate

0.0

75+

43.2

14.4

57.5

14.4

43.2

14.4

71.9

14.4

43.2

14.4

57.5

28.8

Male

963.9

100.7

215.8

0.0

70-

20.2

40.3

20.2

40.3

20.2

40.3

20.2

40.3

20.2

141.1

120.9

846.6

100.8

0.0

65-

30.3

15.1

45.4

15.1

60.6

15.1

45.4

15.1

60.6

15.1

30.3

15.1

30.3

90.8

560.2

0.0

60-

44.5

33.4

11.1

33.4

11.1

55.7

22.3

33.4

11.1

22.3

33.4

44.5

11.1

22.3

11.1

545.5

133.6

9.3

0.0

9.3

0.0

9.3

0.0

9.3

0.0

9.3

0.0

9.3

0.0

9.3

0.0

55-

18.7

28.0

18.7

28.0

364.6

112.2

0.0

7.0

0.0

7.0

0.0

7.0

0.0

50-

21.0

42.0

14.0

83.9

28.0

244.7

2015) Age by Group

0.0

6.0

0.0

6.0

0.0

6.0

0.0

6.0

0.0

6.0

0.0

6.0

0.0

6.0

0.0

6.0

0.0

45-

12.0

47.9

12.0

36.0

18.0

–

233.7

3 3

5.7

0.0

5.7

0.0

5.7

0.0

5.7

0.0

5.7

0.0

5.7

0.0

5.7

0.0

5.7

0.0

5.7

0.0

40-

11.5

85.9

0.0

5.8

35-

46.6

11.7

0.0

6.1

0.0

6.1

0.0

30-

24.2

12.1

0.0

7.0

0.0

7.0

0.0

7.0

0.0

25-

13.9

34.8

0.0

6.8

20-

13.5

0.0

6.3

0.0

6.3

0.0

6.3

0.0

15-

18.9

7.4

0.0

7.4

0.0

10-

0.0

115

Year

No.Case

(2014), Mean annual ASR per ASR (20 100,000 (2014),annual Mean

Klaeng

6.3

Allsites

Otherunspecified and

Myelodysplasticdisease

Leukemia unspecified Leukemia

Myeloidleukemia

Multiplemyeloma

Non-Hodgkinlymphoma

Otherendocrine

Adrenalgland

Thyroid

Brain,nervous system

Bladder

Ureter

Renalpelvis

Kidney

Testis

Prostate

Penis

Ovary

Uterusunspecified

Corpusuteri

Cervixuteri

Vagina

Vulva

Breast

Connectivetissue

Mesothelioma

Otherskin

Melanomaof skin

Bone

Otherorgans thoracic

Trachea, Bronchus and lung and Bronchus Trachea,

Larynx

Nose,etc. sinuses

Pancreas

Gallbladder

Liverbile and duct

Anus

Rectum

Colon

Smallintestine

Stomach

Oesophagus

Hypopharynx

Nasopharynx

Otheroropharynx

Tonsil

Salivaryglands

Mouth

Tongue

Lip

Site Table Table

49 | P a g e

District : Klaeng Cancer Incidence in Rayong, Thailand, 2013-2015

0.4

0.0

0.1

0.2

0.0

0.6

0.4

0.1

0.0

0.2

0.0

1.0

0.1

2.1

0.1

0.0

3.7

0.0

0.1

0.2

0.0

0.1

0.0

1.7

0.0

0.2

0.0

0.7

0.0

0.6

0.1

0.4

0.2

0.1

0.0

0.1

0.0

0.8 0.8

16.1 0 Rate

0.1

0.0

0.1

0.3

0.0

0.4

0.1

0.0

0.1

0.0

0.5

1.2

0.0

3.0

0.0

0.1

0.2

0.0

0.1

0.0

0.7

0.0

0.2

0.0

0.3

0.0

0.3

0.4

0.0

0.2

0.1

0.0

0.1

0.0

0.1

0.0

0.8

10.6 0

Cum

ALL

C95

C90

C75

C74

C73

C67

C66

C65

C64

C62

C61

C60

C56

C55

C54

C53

C52

C51

C50

C45

C44

C43

C32

C25

C23

C21

C17

C16

C15

C11

C10

C09

C00 C18

O&U

ICD-10

C92-94

C70-72

C33-34

C30-31

C19-20

C12-13

C03-06

C01-02

C37-38

C07-08

C47,C49

C22,C24 D45-D47 C40-C41

C82-85,C96

3.6

0.5

0.0

1.4

1.6

5.4

0.0

4.5

0.9

0.4

0.0

1.0

0.0

6.4

0.5

0.4

0.6

3.3

0.0

1.2

0.3

0.0

0.3

5.6

0.0

4.6

5.3

0.7

2.0

1.2

1.3

0.0

1.0

1.2

5.8

0.8

1.8

2.8 0.8

0.8

10.0

19.4

35.3 13.2 146.4

ASRWorld

4.4

1.0

0.0

1.0

2.4

0.0

7.3

1.5

0.5

0.0

1.5

0.0

1.0

0.5

1.0

0.0

1.0

0.5

0.0

2.9

0.5

0.0

7.7

1.0

3.9

3.4

1.9

0.0

1.0

1.5

1.9

1.5

6.8

4.8

8.7

4.8

8.2

6.8

12.6

27.1 19.4 50.8

204.3 ale

CrudeRate

0.0

75+

10.3

61.7

10.3

72.0

41.1

10.3

41.1

20.6

41.1

10.3

20.6

10.3

20.6

Fem 30.8

30.8

575.6

102.8

0.0

0.0 0.0

70-

73.7

36.9

73.7

36.9

18.4

18.4 534.4 129.0

0.0

65-

14.1

42.2

70.4

14.1

28.1

28.1 577.0 140.7

0.0

9.8

9.8 9.8

60-

19.6

39.2

49.0

19.6

29.4

19.6

78.5 529.7 127.5

0.0

7.9

0.0

7.9

0.0

7.9

0.0

7.9

0.0

7.9

0.0

7.9

0.0

7.9

0.0

55-

23.7

63.1

94.7

31.6

23.7

31.6

23.7

15.8

15.8 15.8

442.0

0.0

6.4

0.0

6.4

0.0

6.4

0.0

6.4

0.0

6.4

0.0

6.4

0.0

6.4

0.0

6.4

0.0

50-

32.1

12.9

32.1

12.9

32.1

12.9

12.9 12.9

392.1 147.8

2015) by Age Group 2015)Age by Group

0.0

5.6

0.0

5.6

0.0

5.6

0.0

5.6

0.0

5.6

0.0

5.6

0.0

5.6

0.0

0.0 45-

–

33.6

11.2

240.8 100.8

3 3

0.0

5.7

0.0

5.7

0.0

5.7

0.0

5.7

0.0

5.7

0.0

5.7

0.0

40-

11.3

34.0

67.9

17.0 11.3

175.5

5.7

0.0

5.7

0.0

5.7

0.0

35-

11.5

34.4 57.4 11.5

131.9

0.0

6.4

0.0

6.4

0.0

6.4

0.0

6.4

0.0

6.4

0.0

6.4

0.0

0.0 0.0

30-

25.6 83.2 12.8

0.0

7.3

0.0

7.3

0.0

25- 36.7 22.0

0.0

7.0

0.0

20- 21.0 14.0

6.9

0.0

6.9

0.0

0.0 0.0 15-

0.0

8.3

8.3 10- 16.7

0.0

0.0 8.4 8.4 16.9

9.0

0.0

9.0

0.0

0.0 0.0 17.9

1 1

13 141

Year

(2014), Mean annual ASR per annual (20 100,000 (2014),Mean No.Case

Klaeng

4 .

able able

Allsites

Otherunspecified and

Myelodysplasticdisease

Leukemia unspecified Leukemia

Myeloidleukemia

Multiplemyeloma

Non-Hodgkinlymphoma

Otherendocrine

Adrenalgland

Thyroid

Brain,nervous system

Bladder

Ureter

Renalpelvis

Kidney

Testis

Prostate

Penis

Ovary

Uterusunspecified

Corpusuteri

Cervixuteri

Vagina

Vulva

Breast

Connectivetissue

Mesothelioma

Otherskin

Melanomaof skin

Bone

Otherorgans thoracic

Trachea, Bronchus and lung and Bronchus Trachea,

Larynx

Nose,etc. sinuses

Pancreas

Gallbladder

Liverbile and duct

Anus

Rectum

Colon

Smallintestine

Stomach

Oesophagus

Hypopharynx

Nasopharynx

Otheroropharynx

Tonsil

Salivaryglands

Mouth

Tongue

Lip Site

50 | P a g e

District : Wang Chan Cancer Incidence in Rayong, Thailand, 2013-2015

Wang Chan District Incidence During the period 2013-2015, there were 134 incident cases of new cancer in Wang Chan district residents, 64 among males and 70 among females. The average age-standardized incidence rate was 108.5 per 100,000 population among males and 115.5 among females.

Leading Cancers Colorectal cancer was the most common cancer (ASR = 22.6 per 100,000 population) followed by liver cancer 13.7, lung cancer 12.8, oral cavity 10.2, and esophageal cancer 7.8 among males (Table 7.1). Breast cancer was the most common cancer (ASR = 36.9 per 100,000 population) followed by thyroid cancer 15.0, lung cancer 11.5, ovarian cancer 8.7, and cervical cancer 8.4 among females (Table 7.2).

Figure 7.1 Population pyramid in Wang Chan District, Rayong estimated population in 2014 (average 2013-2015)

459 75+ 610

357 70-74 349 449 65-69 449 639 60-64 664 798 55-59 835 1,078 50-54 1,122

1,211 45-49 1,234 1,337 40-44 1,321 1,466 35-39 1,390 1,396 30-34 1,255

1,146 25-29 1,150 1,114 20-24 1,116 1,254 15-19 1,103 1,164 10-14 1,019 1,174 5-9 991 1,107 0-4 992 1600 1400 1200 1000 800 600 400 200 0 0 200 400 600 800 1000 1200 1400 MALE FEMALE

51 | P a g e

District : Wang Chan Cancer Incidence in Rayong, Thailand, 2013-2015

Table 7.1 Leading cancer in Wang Chan District, Rayong (Male) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Colon and Rectum 5 28.9 22.6 2 Liver and bile duct 3 16.5 13.7 3 Trachea, Bronchus, and lung 3 16.5 12.8 4 Oral cavity 2 12.4 10.2 5 Oesophagus 1 8.3 7.8 All Sites 21 132.1 108.5

Table 7.2 Leading cancer in Wang Chan District, Rayong (Female) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Breast 8 49.1 36.9 2 Thyroid 3 19.2 15.0 3 Trachea, Bronchus, and lung 2 15.0 11.5 4 Ovary 2 10.7 8.7 5 Cervix uteri 2 10.7 8.4 All Sites 23 149.6 115.5

52 | P a g e

District : Wang Chan Cancer Incidence in Rayong, Thailand, 2013-2015

Figure 7.2 Leading cancer in Wang Chan District, Rayong (mean annual ASR 2013-2015)

ASR (World)

53 | P a g e

Districts : Wang Chan Cancer Incidence in Rayong, Thailand, 2013-2015

0.4

0.0

0.1

0.5

0.7

0.0

0.6

0.5

0.2

0.5

0.1

0.0

0.3

1.5

1.2

0.0

0.9

0.1

0.9

0.3

0.8

11.2

Rate

7.1

0.0

0.1

0.5

0.3

0.0

0.6

0.0

0.2

0.0

0.1

0.0

0.3

1.5

0.1

0.0

0.9

0.1

0.4

0.3

0.8

Cum

ALL

C95

C91

C90

C73

C67

C61

C60

C56

C53

C50

C44

C25

C16

C15

C09

C81

C18

O&U

ICD-10

C70-72

C33-34

C30-31

C19-20

C03-06

C01-02

C37-38

C22,C24

D45-D47

C82-85,C96

3.7

1.5

1.7

2.6

4.2

5.4

0.0

6.3

1.9

3.1

3.3

1.5

0.0

1.5

0.0

2.1

1.5

1.4

7.0

3.2

7.8

13.7

11.3

12.8

108.5

ASRWorld

Male

4.1

2.1

4.1

6.2

0.0

2.1

4.1

2.1

0.0

2.1

0.0

2.1

4.1

8.3

16.5

14.5

132.1

CrudeRate

0.0

75+

72.6

290.5

217.9

145.3

1380.1

0.0

70-

93.3

746.6

280.0

0.0

65-

74.3

0.0

60-

52.2

574.0

104.4

156.6

2015) by Age Group Group 2015)Age by

0.0

55-

83.6

41.8

83.6

125.4

459.8

–

3 3

0.0

50-

30.9

61.9

30.9

185.6

0.0

45-

55.1

27.5

0.0

40-

24.9

74.8

0.0

35-

45.5

22.7

0.0

30-

0.0

25-

0.0

20-

0.0

15-

0.0

10-

28.6

0.0

(2014), Mean annual ASR per 100,000 (20ASR 100,000per annual (2014),Mean

Year

No.Case

Wang Chan Wang

7.3

Allsites

Otherunspecified and

Myelodysplasticdisease

Leukemia unspecified

Lymphoidleukemia

Multiplemyeloma

Non-Hodgkinlymphoma

Hodgkindisease

Thyroid

Brain,nervous system

Bladder

Prostate

Penis

Ovary

Cervixuteri

Breast

Otherskin

Otherorgans thoracic

Trachea, Bronchus and lung and Bronchus Trachea,

Nose,etc. sinuses

Pancreas

Liverbile and duct

Rectum

Colon

Stomach

Oesophagus

Tonsil

Mouth

Tongue

Site Table Table

54 | P a g e

Districts : Wang Chan Cancer Incidence in Rayong, Thailand, 2013-2015

1.0

0.0

0.1

1.6

0.0

0.4

0.0

1.4

1.2

0.5

0.3

1.7

0.1

0.0

0.6

0.1

0.6

0.0

3.8

- 13.4 0 Rate

0.5

0.0

0.1

1.1

0.0

0.5

0.4

2.7

0.5

0.3

0.7

0.1

0.0

0.2

0.1

0.6

0.0

0.0 7.8

- 0 Cum

ALL

C95

C91

C90

C73

C67

C61

C60

C56

C53

C50

C44

C25

C16

C15

C09

C81

C18

O&U

ICD-10

C70-72

C33-34

C30-31

C19-20

C03-06 C01-02

C37-38 C22,C24 D45-D47

C82-85,C96

6.9

0.0

1.1

0.0

2.4

0.0

2.2

0.0

4.7

2.0

1.5

2.2

4.9

1.5

5.6

0.0

8.7

8.4

15.0 36.9

11.5 115.5

ASRWorld

ale

0.0

2.1

0.0

2.1

0.0

2.1

0.0

6.4

2.1

4.3

6.4

2.1

6.4

0.0

8.5

19.2

10.7

10.7 49.1

15.0 149.6

Fem

- CrudeRate

0.0

75+

54.6

54.6 54.6

54.6 109.3

382.4

0.0

0.0 0.0

70-

95.6

669.5 191.3 191.3

0.0

65-

74.2 74.2

74.2

445.4 222.7

by Age Group Group Age by

0.0

0.0 0.0

60-

50.2

50.2 100.3 250.8

0.0

55-

39.9

79.8 279.3

2015)

–

0.0

50-

29.7 89.1

3 3

326.8 208.0

0.0

0.0 0.0

45-

54.0

27.0

27.0 297.1 135.1

0.0

40-

50.5

25.2

25.2 25.2

176.6

0.0

35-

24.0 72.0 24.0

119.9

0.0

0.0 0.0

30- 53.1 53.1

0.0

0.0 0.0 25-

0.0

20-

59.7 29.9 29.9

0.0

0.0 0.0 15-

0.0

0.0 0.0 10-

0.0

0.0 0.0 0.0

0.0

0.0 0.0

0.0 (2014), Mean annual ASR per 100,000 (20ASR 100,000per annual (2014),Mean

8 23

Year No.Case

Wang Chan Wang

4 .

Allsites

Otherunspecified and

Myelodysplasticdisease

Leukemia unspecified

Lymphoidleukemia

Multiplemyeloma

Non-Hodgkinlymphoma

Hodgkindisease

Thyroid

Brain,nervous system

Bladder

Prostate

Penis

Ovary

Cervixuteri

Breast

Otherskin

Otherorgans thoracic

Trachea, Bronchus and lung and Bronchus Trachea,

Nose,etc. sinuses

Pancreas

Liverbile and duct

Rectum

Colon

Stomach

Oesophagus

Tonsil

Mouth

Tongue

Site Table Table

55 | P a g e

Districts : Ban Khai Cancer Incidence in Rayong, Thailand, 2013-2015

Ban Khai District Incidence During the period 2013-2015, there were 322 incident cases of new cancer in Ban Khai district residents, 165 among males and 157 among females. The average age-standardized incidence rate was 109.9 per 100,000 population among males and 95.6 among females.

Leading Cancers Lung cancer was the most common cancer (ASR = 17.3 per 100,000 population) followed by liver cancer 12.8, colorectal cancer 12.6, esophageal cancer 8.9, and laryngeal cancer 5.5 among males (Table 8.1). Breast cancer was the most common cancer (ASR = 19.4 per 100,000 population) followed by cervical cancer 8.5, lung cancer 7.8, ovarian cancer 6.6, and colorectal cancer 5.5 among females (Table 8.2).

Figure 8.1 Population pyramid in Ban Khai District, Rayong estimated population in 2014 (average 2013-2015)

1,367 75+ 1,919 955 70-74 1,060 1,219 65-69 1,380 1,692 60-64 1,831 2,137 55-59 2,448 2,854 50-54 3,135

3,319 45-49 3,495 3,564 40-44 3,495 3,554 35-39 3,268 3,222 30-34 3,014

2,709 25-29 2,586 2,761 20-24 2,650 2,895 15-19 2,600 2,395 10-14 2,125 2,501 5-9 2,247 2,491 0-4 2,311 4000 3500 3000 2500 2000 1500 1000 500 0 0 500 1000 1500 2000 2500 3000 3500 29,333 MALE FEMALE

56 | P a g e

Districts : Ban Khai Cancer Incidence in Rayong, Thailand, 2013-2015 Table 8.1 Leading cancer in Ban Khai District, Rayong (Male) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Trachea, Bronchus, and lung 9 22.7 17.3 2 Liver and bile duct 7 16.8 12.8 3 Colon and Rectum 7 16.8 12.6 4 Oesophagus 4 10.9 8.9 5 Larynx 3 7.6 5.5 All Sites 55 138.8 109.9

Table 8.2 Leading cancer in Ban Khai District, Rayong (Female) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Breast 11 27.0 19.4 2 Cervix uteri 5 12.6 8.5 3 Trachea, Bronchus, and lung 5 12.6 7.8 4 Ovary 4 9.3 6.6 5 Colon and Rectum 4 9.3 5.5 All Sites 52 132.3 95.6

57 | P a g e

Districts : Ban Khai Cancer Incidence in Rayong, Thailand, 2013-2015

Figure 8.2 Leading cancer in Ban Khai District, Rayong (mean annual ASR 2013-2015)

ASR (World)

58 | P a g e

Districts : Ban Khai Cancer Incidence in Rayong, Thailand, 2013-2015

0.7

0.0

0.4

0.2

0.1

0.3

0.0

0.6

0.1

0.7

0.0

0.5

0.0

0.1

0.2

2.4

0.4

0.0

0.4

0.0

1.5

0.0

0.7

0.6

0.1

1.2

0.4

0.3

0.0

0.4

13.0

Rate

6.7

0.4

0.0

0.1

0.2

0.1

0.0

0.3

0.1

0.3

0.0

0.3

0.0

0.1

0.4

0.0

0.1

0.0

1.1

0.0

0.5

0.1

0.6

0.1

0.3

0.0

0.2

0.8

Cum

ALL

C95

C91

C90

C74

C73

C67

C64

C61

C60

C56

C54

C53

C52

C50

C44

C43

C32

C25

C23

C21

C16

C15

C11

C09

C18

O&U

ICD-10

C92-94

C70-72

C33-34

C30-31

C19-20

C12-13

C03-06

C01-02

C37-38

C47,C49

C22,C24

D45-D47

C40-C41

C82-85,C96

7.0

0.6

0.5

3.4

2.9

1.2

2.7

0.0

0.6

4.2

1.4

5.3

0.5

0.0

0.6

4.3

0.6

1.3

5.5

0.0

6.4

6.2

1.3

2.1

2.7

2.0

0.0

3.9

2.8

8.9

17.3

12.8

109.9

ASRWorld

7.6

3.4

2.5

1.7

3.4

0.0

5.0

1.7

6.7

0.0

5.0

1.7

7.6

0.0

3.4

0.0

1.7

2.5

3.4

2.5

0.0

5.0

0.8

8.4

22.7

10.9

16.8

138.8

Male

CrudeRate

0.0

75+

24.4

73.1

97.5

24.4

48.8

706.9

121.9

0.0

70-

34.9

69.8

663.2

209.4

0.0

65-

54.7

27.3

54.7

27.3

54.7

27.3

601.7

109.4

0.0

60-

19.7

39.4

59.1

19.7

59.1

19.7

59.1

39.4

512.2

0.0

55-

31.2

15.6

31.2

62.4

15.6

46.8

2015) by Age Group 2015)Group Age by

249.6

–

0.0

50-

11.7

23.4

11.7

23.4

58.4

81.8

3 3

221.9

0.0

45-

20.1

10.0

30.1

10.0

20.1

10.0

20.1

10.0

140.6

0.0

9.4

0.0

9.4

0.0

9.4

0.0

9.4

0.0

9.4

0.0

40-

84.2

18.7

0.0

9.4

0.0

9.4

0.0

9.4

0.0

35-

28.1

0.0

30-

41.4

10.3

20.7

0.0

25-

12.3

0.0

20-

0.0

15-

0.0

10-

0.0

26.7

13.3

0.0

13.4

(2014), Mean annual ASR (20(2014),100,000per annual Mean

Year

No.Case

Ban Khai Ban

8.3

Allsites

Otherunspecified and

Myelodysplasticdisease

Leukemia unspecified Leukemia

Myeloidleukemia

Lymphoidleukemia

Multiplemyeloma

Non-Hodgkinlymphoma

Adrenalgland

Thyroid

Brain,nervous system

Bladder

Kidney

Prostate

Penis

Ovary

Corpusuteri

Cervixuteri

Vagina

Breast

Connectivetissue

Otherskin

Melanomaof skin

Bone

Otherorgans thoracic

Trachea, Bronchus and lung and Bronchus Trachea,

Larynx

Nose,etc. sinuses

Pancreas

Gallbladder

Liverbile and duct

Anus

Rectum

Colon

Stomach

Oesophagus

Hypopharynx

Nasopharynx

Tonsil

Mouth

Tongue

Site Table Table

59 | P a g e

Districts : Ban Khai Cancer Incidence in Rayong, Thailand, 2013-2015

0.2

0.0

0.2

0.3

0.1

0.3

0.4

0.0

0.1

0.0

0.6

0.3

0.9

0.0

2.3

0.1

0.4

0.0

0.3

0.0

0.5

0.0

0.1

0.4

0.1

0.2

0.1

0.2

0.0

0.2

0.3

0.8

10.1

Rate

6.5

0.1

0.0

0.2

0.0

0.1

0.3

0.1

0.3

0.0

0.1

0.0

0.6

0.3

0.6

0.0

1.6

0.1

0.4

0.0

0.1

0.0

0.6

0.0

0.2

0.0

0.1

0.3

0.1

0.2

0.1

0.0

0.1

0.0

Cum

ALL

C95

C91

C90

C74

C73

C67

C64

C61

C60

C56

C54

C53

C52

C50

C44

C43

C32

C25

C23

C21

C16

C15

C11

C09

C18

O&U

ICD-10

C92-94

C70-72

C33-34

C30-31

C19-20

C12-13

C03-06

C01-02

C37-38

C47,C49

C22,C24

D45-D47

C40-C41

C82-85,C96

1.5

0.0

1.3

2.9

1.4

1.3

1.7

2.0

0.3

0.9

0.0

6.6

2.7

0.6

1.0

0.0

2.7

0.0

0.3

0.0

0.3

0.0

0.5

4.9

0.9

0.5

1.5

0.0

1.7

1.4

5.8

3.8

8.5

3.8

7.8

5.8

1.8

95.6

19.4

ASRWorld

ale

1.7

0.0

1.7

3.4

1.7

7.6

5.1

2.5

1.7

0.0

9.3

4.2

5.1

0.0

2.5

0.0

7.6

1.7

2.5

1.7

0.0

1.7

0.8

12.6

27.0

12.6

132.3

Fem

CrudeRate

0.0

75+

17.4

34.7

17.4

69.5

17.4

69.5

17.4

434.3

0.0

70-

31.4

62.9

31.4

345.9

0.0

65-

24.2

72.5

24.2

48.3

362.3

0.0

60-

36.4

54.6

36.4

18.2

309.5

0.0

55-

13.6

27.2

40.9

13.6

2015) by Age Group 2015)Group Age by

286.0

108.9

–

0.0

50-

10.6

31.9

21.3

42.5

31.9

21.3

10.6

3 3

170.1

0.0

9.5

0.0

9.5

0.0

9.5

0.0

9.5

0.0

9.5

0.0

45-

19.1

47.7

28.6

152.6

0.0

9.5

0.0

9.5

0.0

9.5

0.0

9.5

0.0

9.5

0.0

40-

19.1

47.7

152.6

0.0

35-

20.4

10.2

40.8

0.0

30-

44.2

11.1

0.0

25-

51.6

12.9

0.0

20-

37.7

12.6

0.0

15-

0.0

10-

31.4

15.7

0.0

14.4

28.8

(2014), Mean annual ASR (20(2014),100,000per annual Mean

Year

No.Case

Ban Khai Ban

8.4

Allsites

Otherunspecified and

Myelodysplasticdisease

Leukemia unspecified Leukemia

Myeloidleukemia

Lymphoidleukemia

Multiplemyeloma

Non-Hodgkinlymphoma

Adrenalgland

Thyroid

Brain,nervous system

Bladder

Kidney

Prostate

Penis

Ovary

Corpusuteri

Cervixuteri

Vagina

Breast

Connectivetissue

Otherskin

Melanomaof skin

Bone

Otherorgans thoracic

Trachea, Bronchus and lung and Bronchus Trachea,

Larynx

Nose,etc. sinuses

Pancreas

Gallbladder

Liverbile and duct

Anus

Rectum

Colon

Stomach

Oesophagus

Hypopharynx

Nasopharynx

Tonsil

Mouth

Tongue

Site Table Table

60 | P a g e

Districts : Pluak Daeng Cancer Incidence in Rayong, Thailand, 2013-2015

Pluak Daeng District Incidence During the period 2013-2015, there were 253 incident cases of new cancer in Pluak Daeng district residents, 118 among males and 135 among females. The average age-standardized incidence rate was 128.2 per 100,000 population among males and 126.4 among females.

Leading Cancers Colorectal cancer was the most common cancer (ASR = 23.8 per 100,000 population) followed by liver cancer 17.6, lung cancer 17.5, prostate cancer 8.6, and oral cavity cancer 8.3 among males (Table 9.1). Breast cancer was the most common cancer (ASR = 23.3 per 100,000 population) followed by cervical cancer 20.3, lung cancer 15.2, liver cancer 13.9, and colorectal cancer 8.1 among females (Table 8.2).

Figure 9.1 Population pyramid in Pluak Daeng district, Rayong estimated population in 2014 (average 2013-2015)

638 75+ 854 469 70 -74 471 600 65-69 700 911 60-64 986 1,236 55-59 1,321 1,755 50-54 1,783

2,604 45-49 2,311 3,065 40-44 2,750 4,060 35-39 3,243 4,231 30-34 3,820

2,849 25-29 2,873 2,073 20-24 2,164 2,207 15-19 2,066 2,071 10-14 1,929 2,611 5-9 2,339 2,842 0-4 2,578 4500 4000 3500 3000 2500 2000 1500 1000 500 0 0 500 1000 1500 2000 2500 3000 3500 400029,333 MALE FEMALE

61 | P a g e

Districts : Pluak Daeng Cancer Incidence in Rayong, Thailand, 2013-2015

Table 9.1 Leading cancer in Pluak Daeng District, Rayong (Male) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Colon and Rectum 7 19.5 23.8 2 Liver and bile duct 6 17.5 17.6 3 Trachea, Bronchus, and lung 5 14.6 17.5 4 Prostate 2 6.8 8.6 5 Oral cavity 2 6.8 8.3 All Sites 39 114.9 128.2

Table 9.2 Leading cancer in Pluak Daeng District, Rayong (Female) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Breast 8 25.9 23.3 2 Cervix uteri 7 22.8 20.3 3 Trachea, Bronchus, and lung 5 15.5 15.2 4 Liver and bile duct 4 13.5 13.9 5 Colon and Rectum 3 9.3 8.1 All Sites 45 139.8 126.4

62 | P a g e

Districts : Pluak Daeng Cancer Incidence in Rayong, Thailand, 2013-2015

Figure 9.2 Leading cancer in Pluak Daeng District, Rayong (mean annual ASR 2013-2015)

ASR (World)

63 | P a g e

Districts : Pluak Daeng Cancer Incidence in Rayong, Thailand, 2013-2015

0.5

0.1

0.2

0.1

0.2

0.3

0.1

0.7

0.1

0.0

0.9

0.0

0.4

1.7

0.3

0.0

0.1

0.4

2.1

0.3

0.9

2.3

0.4

0.3

0.2

0.3

0.0

0.2

0.0

0.5

0.0

14.6 0

Rate

7.1

0.5

0.1

0.2

0.1

0.2

0.3

0.1

0.2

0.1

0.0

0.3

0.0

0.1

0.0

0.1

0.0

1.0

0.0

0.5

0.7

0.1

0.4

0.3

0.2

0.3

0.0

0.2

0.0

0.3

0.0

0.8

- 0

Cum

ALL

C95

C91

C90

C73

C67

C64

C62

C61

C56

C54

C53

C51

C50

C44

C32

C25

C23

C21

C17

C16

C15

C11

C09

C00 C58

C18

O&U

ICD-10

C92-94

C70-72

C33-34

C30-31

C19-20

C12-13

C03-06

C01-02

C07-08

C47,C49

C22,C24 C40-C41

C82-85,C96

6.3

1.3

2.0

1.4

2.2

2.5

5.9

0.5

0.0

1.0

3.0

2.4

0.0

0.9

1.4

1.7

6.2

2.1

3.9

3.1

2.0

3.0

0.0

2.4

1.0

4.9

0.0

1.8

4.8

0.8

8.6

17.5

17.6

15.9 128.2

ASRWorld

Male

1.0

2.9

1.0

1.9

2.9

1.9

4.9

2.9

1.0

0.0

1.0

1.9

0.0

1.0

1.9

3.9

1.9

3.9

0.0

1.9

1.0

3.9

0.0

5.8

6.8

5.8

14.6

17.5 12.7

114.9 CrudeRate

0.0

75+

52.3

104.5

313.6

156.8 888.5

0.0

70-

71.0

142.0

568.1

0.0

65-

55.6

55.6 55.6

55.6

944.7

111.1

222.3

166.7

0.0

60-

73.2

36.6

73.2 73.2

36.6

365.9

2015) by Age Group Age by 2015)

0.0

55-

–

27.0

53.9

27.0

53.9 80.9

323.6

3 3

0.0

50-

19.0

38.0

38.0 38.0

247.0

0.0

45-

25.6

51.2

25.6

12.8

12.8 12.8

256.0

0.0

40-

76.1

10.9

10.9 32.6

0.0

8.2

35-

24.6 16.4

0.0

7.9

0.0

7.9

0.0

7.9

0.0

7.9

0.0

30-

47.3

15.8

0.0

0.0 0.0

25-

0.0

20-

32.2 16.1

16.1

0.0

0.0 0.0

15-

0.0

0.0 0.0

10-

0.0

25.5 12.8

12.8

0.0

11.7

11.7 (2014), Mean annual ASR per 100,000 (20 ASR 100,000per annual (2014),Mean

0 39

Year No.Case

Pluak Daeng Pluak

9.3

able able

Allsites

Otherunspecified and

Leukemia unspecified Leukemia

Myeloidleukemia

Lymphoidleukemia

Multiplemyeloma

Non-Hodgkinlymphoma

Thyroid

Brain,nervous system

Bladder

Kidney

Testis

Prostate

Placenta

Ovary

Corpusuteri

Cervixuteri

Vulva

Breast

Connectivetissue

Otherskin

Bone

Trachea, Bronchus and lung and Bronchus Trachea,

Larynx

Nose,etc. sinuses

Pancreas

Gallbladder

Liverbile and duct

Anus

Rectum

Colon

Smallintestine

Stomach

Oesophagus

Hypopharynx

Nasopharynx

Tonsil

Salivaryglands

Mouth

Tongue

Lip

Site T

64 | P a g e

Districts : Pluak Daeng Cancer Incidence in Rayong, Thailand, 2013-2015

0.1

0.0

0.2

0.0

0.6

0.5

0.0

0.1

0.3

0.5

2.1

0.0

2.4

0.0

0.2

0.1

0.0

0.1

0.6

0.4

1.6

0.0

0.4

0.3

0.0

0.4

0.0

0.1

0.2

0.0

0.1

1.8

13.2

Rate

9.2

0.1

0.0

0.2

0.0

0.1

0.5

0.0

0.1

0.3

0.5

1.7

0.0

2.2

0.0

0.2

0.1

0.7

0.0

0.1

0.0

0.1

1.1

0.0

0.3

0.0

0.4

0.0

0.1

0.2

0.0

0.1

Cum

ALL

C95

C91

C90

C73

C67

C64

C62

C61

C56

C54

C53

C51

C50

C44

C32

C25

C23

C21

C17

C16

C15

C11

C09

C00

C58

C18

O&U

ICD-10

C92-94

C70-72

C33-34

C30-31

C19-20

C12-13

C03-06

C01-02

C07-08

C47,C49

C22,C24

C40-C41

C82-85,C96

1.0

0.0

2.2

0.0

4.3

6.1

0.0

1.2

2.9

4.6

1.3

1.4

1.0

0.0

1.0

2.3

0.0

4.5

3.6

0.0

5.4

1.6

0.0

0.5

0.9

2.4

0.0

1.2

0.7

0.8

2.8

20.3

23.3

15.2

13.9

126.4

ASRWorld

ale

1.0

0.0

2.1

0.0

4.1

9.3

0.0

1.0

3.1

5.2

1.0

2.1

1.0

0.0

1.0

2.1

0.0

5.2

4.1

0.0

6.2

2.1

0.0

1.0

3.1

0.0

2.1

1.0

25.9

15.5

13.5

22.8

139.8

Fem

CrudeRate

0.0

75+

39.0

78.1

585.7

117.1

156.2

0.0

70-

70.8

283.1

0.0

65-

95.2

47.6

95.2

523.7

142.8

0.0

60-

67.6

33.8

439.5

135.2

101.4

0.0

55-

25.2

75.7

25.2

2015) by Age Group Age by 2015)

327.9

–

0.0

50-

37.4

56.1

37.4

3 3

18.7

336.5

0.0

45-

14.4

57.7

14.4

43.3

14.4

86.5

28.8

302.9

0.0

40-

24.2

36.4

12.1

133.3

0.0

35-

20.6

41.1

10.3

20.6

30.8

123.3

0.0

8.7

30-

96.0

26.2

17.4

0.0

25-

34.8

11.6

0.0

20-

46.2

15.4

0.0

15-

0.0

10-

0.0

(2014), Mean annual ASR per 100,000 (20 ASR 100,000per annual (2014),Mean

Year

No.Case

Pluak Daeng Pluak

9.4

Allsites

Otherunspecified and

Leukemia unspecified Leukemia

Myeloidleukemia

Lymphoidleukemia

Multiplemyeloma

Non-Hodgkinlymphoma

Thyroid

Brain,nervous system

Bladder

Kidney

Testis

Prostate

Placenta

Ovary

Corpusuteri

Cervixuteri

Vulva

Breast

Connectivetissue

Otherskin

Bone

Trachea, Bronchus and lung and Bronchus Trachea,

Larynx

Nose,etc. sinuses

Pancreas

Gallbladder

Liverbile and duct

Anus

Rectum

Colon

Smallintestine

Stomach

Oesophagus

Hypopharynx

Nasopharynx

Tonsil

Salivaryglands

Mouth

Tongue

Lip

Site Table Table

65 | P a g e

Districts : Khao Chamao Cancer Incidence in Rayong, Thailand, 2013-2015

Khao Chamao District Incidence During the period 2013-2015, there were 98 incident cases of new cancer in Khao Chamao district residents, 59 among males and 39 among females. The average age-standardized incidence rate was 116.2 per 100,000 population among males and 71.9 among females.

Leading Cancers Lung cancer was the most common cancer (ASR = 22.4 per 100,000 population) followed by liver cancer 15.3, esophageal cancer 10.7, oral cavity cancer 10.4, and Non- Hodgkin lymphoma 7.4 among males (Table 10.1). Breast cancer was the most common cancer (ASR = 22.3 per 100,000 population) followed by cervical cancer 9.2, lung cancer 7.3, oral cavity cancer 3.6, and thyroid cancer 3.5 among females (Table 10.2).

Figure 10.1 Population pyramid in Khao Chamao district, Rayong estimated population in 2014 (average 2013-2015 425 75+ 528 312 70-74 327 410 65-69 430 596 60-64 564 757 55-59 728 933 50-54 1,025

1,171 45-49 1,134 1,202 40-44 1,171 1,274 35-39 1,161 1,201 30-34 1,142

1,137 25-29 1,025 1,141 20-24 1,059 1,199 15-19 1,078 1,066 10-14 939 1,026 5-9 924 1,017 0-4 822 1400 1200 1000 800 600 400 200 0 0 200 400 600 800 1000 1200 29,333 MALE FEMALE

66 | P a g e

Districts : Khao Chamao Cancer Incidence in Rayong, Thailand, 2013-2015

Table 10.1 Leading cancer in Khao Chamao District, Rayong (Male) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Trachea, Bronchus, and lung 4 24.7 22.4 2 Liver and bile duct 3 17.9 15.3 3 Oesophagus 2 112 10.7 4 Oral cavity 2 11.2 10.4 5 Non-Hodgkin lymphoma 1 9.0 7.4 All Sites 20 132.3 116.2

Table 10.2 Leading cancer in Khao Chamao District, Rayong (Female) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Breast 4 28.3 22.3 2 Cervix uteri 2 14.2 9.2 3 Trachea, Bronchus, and lung 1 9.4 7.3 4 Oral cavity 1 4.7 3.6 5 Thyroid 1 4.7 3.5 All Sites 13 92.1 71.9

67 | P a g e

Districts : Khao Chamao Cancer Incidence in Rayong, Thailand, 2013-2015

Figure 10.2 Leading cancer in Khao Chamao District, Rayong (mean annual ASR 2013-2015)

ASR (World)

68 | P a g e

Districts : Khao Chamao Cancer Incidence in Rayong, Thailand, 2013-2015

0.4

0.0

0.9

0.0

0.1

0.0

0.4

0.0

3.4

0.7

0.2

0.0

1.9

0.5

0.0

0.5

1.5

0.1

0.3

0.5

0.9

0.4

0.3

0.8

15.2

Rate

6.6

0.4

0.0

0.5

0.0

0.1

0.0

0.4

0.0

1.0

0.2

0.0

1.0

0.0

0.5

0.7

0.1

0.3

0.5

0.0

0.4

0.3

Cum

ALL

C73

C67

C61

C54

C53

C50

C44

C32

C25

C23

C16

C15

C14

C11

C10

C81

C18

O&U

ICD-10

C92-94

C70-72

C33-34

C19-20

C12-13

C03-06

C01-02

C07-08

C22,C24

C40-C41

C82-85,C96

5.0

0.0

7.4

0.0

1.6

0.0

2.4

5.6

0.0

6.4

0.0

3.9

0.0

2.1

1.6

5.6

1.7

2.2

5.5

4.6

4.9

3.3

2.2

1.8

22.4

15.3

10.7

116.2

ASRWorld

Male

6.7

0.0

9.0

0.0

2.2

0.0

2.2

6.7

0.0

6.7

0.0

4.5

2.2

0.0

2.2

6.7

2.2

6.7

4.5

2.2

24.7

17.9

11.2

132.3

CrudeRate

0.0

75+

78.5

470.9

157.0

0.0

70-

747.9

320.5

106.8

0.0

65-

81.2

974.7

162.5

0.0

60-

55.9

503.2

111.8

2015) by Age Group 2015)Age by

–

0.0

55-

44.1

3 3

264.4

0.0

50-

35.7

142.8

0.0

45-

28.5

85.4

28.5

142.3

,000 (20 ,000

0.0

40-

27.7

0.0

35-

26.2

130.8

0.0

30-

27.8

111.0

0.0

25-

0.0

20-

0.0

15-

0.0

10-

0.0

(2014), Mean annual ASR (2014),100per annual Mean

0.0

Year

No.Case

Khao Chamao Khao

10.3

Table Table

Allsites

Otherunspecified and

Myeloidleukemia

Non-Hodgkinlymphoma

Hodgkindisease

Thyroid

Brain,nervous system

Bladder

Prostate

Corpusuteri

Cervixuteri

Breast

Otherskin

Bone

Trachea, Bronchus and lung and Bronchus Trachea,

Larynx

Pancreas

Gallbladder

Liverbile and duct

Rectum

Colon

Stomach

Oesophagus

Pharynx unspecified Pharynx

Hypopharynx

Nasopharynx

Otheroropharynx

Salivaryglands

Mouth

Tongue Site

69 | P a g e

Districts : Khao Chamao Cancer Incidence in Rayong, Thailand, 2013-2015

7.3

0.6

0.2

0.0

0.2

0.3

0.2

0.0

0.5

0.6

2.3

0.0

0.2

1.0

0.0

0.4

0.2

0.0

0.2

0.0

0.0 0.4

- 0

Rate

5.1

0.6

0.2

0.0

0.2

0.3

0.2

0.0

0.6

2.3

0.0

0.2

0.1

0.0

0.2

0.0

0.2

0.0

Cum

ALL

C73

C67

C61

C54

C53

C50

C44

C32

C25

C23

C16

C15

C14

C11

C10

C81

C18

O&U

ICD-10

C92-94

C70-72

C33-34

C19-20

C12-13

C03-06

C01-02

C07-08

C22,C24

C40-C41

C82-85,C96

ale

5.7

0.0

2.5

3.5

0.0

2.0

9.2

1.3

2.5

7.3

0.0

1.3

2.3

0.0

1.3

2.3

1.8

2.8

71.9

22.3

Fem

ASRWorld

7.1

2.4

0.0

2.4

4.7

2.4

0.0

2.4

9.4

0.0

2.4

0.0

2.4

0.0

2.4

92.1

14.2

28.3

CrudeRate

0.0

75+

63.1

126.2

378.6

0.0

70-

203.7

101.9

0.0

65-

77.6

232.7

2015) by Age Group 2015)Age by

0.0

60-

59.1

–

177.2

118.1

3 3

0.0

55-

45.8

274.9

137.4

0.0

50-

97.6

32.5

65.0

0.0

45-

29.4

88.2

0.0

40-

28.5

85.4

28.5

170.7

0.0

35-

57.4

0.0

30-

29.2

58.4

0.0

25-

0.0

20-

63.0

31.5

0.0

15-

30.9

0.0

10-

0.0

(2014), Mean annual ASR (20 (2014),100,000 per annual Mean

0.0

Year

No.Case

Khao Chamao Khao

10.4

Allsites

Otherunspecified and

Myeloidleukemia

Non-Hodgkinlymphoma

Hodgkindisease

Thyroid

Brain,nervous system

Bladder

Prostate

Corpusuteri

Cervixuteri

Breast

Otherskin

Bone

Trachea, Bronchus and lung and Bronchus Trachea,

Larynx

Pancreas

Gallbladder

Liverbile and duct

Rectum

Colon

Stomach

Oesophagus

Pharynx unspecified Pharynx

Hypopharynx

Nasopharynx

Otheroropharynx

Salivaryglands

Mouth

Tongue

Site Table Table

70 | P a g e

Districts : Nikhom Patthana Cancer Incidence in Rayong, Thailand, 2013-2015

Nikhom Patthana District Incidence During the period 2013-2015, there were 178 incident cases of new cancer in Nikhom Patthana district residents, 82 among males and 96 among females. The average age-standardized incidence rate was 103.3 per 100,000 population among males and 107.7 among females.

Leading Cancers Colorectal cancer was the most common cancer (ASR = 18.4 per 100,000 population) followed by lung cancer 13.3, liver cancer 11.5, esophageal cancer 11.2, and oral cavity cancer 6.9 among males (Table 11.1). Breast cancer was the most common cancer (ASR = 23.8 per 100,000 population) followed by cervical cancer 17.7, colorectal cancer 15.4, thyroid cancer 9.5, and lung cancer 9.2 among females (Table 11.2).

Figure 11.1 Population pyramid in Nikhom Patthana district, Rayong estimated population in 2014 (average 2013-2015) 538 75+ 723 369 70-74 436 478 65-69 604 763 60-64 883 1,162 55-59 1,160 1,688 50-54 1,672

2,315 45-49 2,162 2,522 40-44 2,315 2,555 35-39 2,414 2,436 30-34 2,400

1,831 25-29 2,012 1,794 20-24 1,918 1,985 15-19 1,811 1,776 10-14 1,613 2,143 5-9 1,871 2,117 0-4 1,910 3000 2500 2000 1500 1000 500 0 0 500 1000 1500 2000 2500 29,333 MALE FEMALE

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Districts : Nikhom Patthana Cancer Incidence in Rayong, Thailand, 2013-2015

Table 11.1 Leading cancer in Nikhom Patthana District, Rayong (Male) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Colon and Rectum 5 17.6 18.4 2 Trachea, Bronchus, and lung 3 11.3 13.3 3 Liver and bile duct 3 13.9 11.5 4 Oesophagus 2 8.8 11.2 5 Oral cavity 2 7.6 6.9 All Sites 27 103.3 103.3

Table 11.2 Leading cancer in Nikhom Patthana District, Rayong (Female) (mean annual ASR 2013-2015)

No. Site No. Case Year Crude rate ASR 1 Breast 8 30.9 23.8 2 Cervix uteri 5 19.3 17.7 3 Colon and Rectum 4 15.4 15.4 4 Thyroid 3 11.6 9.5 5 Trachea, Bronchus, and lung 3 10.3 9.2 All Sites 32 123.5 107.7

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Districts : Nikhom Patthana Cancer Incidence in Rayong, Thailand, 2013-2015

Figure 11.2 Leading cancer in Nikhom Patthana District, Rayong (mean annual ASR 2013-2015)

ASR (World)

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Districts : Nikhom Patthana

Cancer Incidence in Rayong, Thailand, 2013-2015

0.5

0.1

0.2

0.1

0.2

0.0

0.1

0.2

0.0

0.1

0.0

0.2

0.1

0.0

1.7

0.2

0.3

1.3

0.3

0.1

1.5

0.0

0.1

0.2

0.1

0.2

0.5

0.0

0.8

10.8

Rate

6.4

0.5

0.1

0.2

0.1

0.2

0.0

0.1

0.2

0.0

0.1

0.0

0.2

0.1

0.0

0.5

0.2

0.3

0.1

1.0

0.0

0.1

0.7

0.0

0.1

0.2

0.1

0.2

0.1

0.0

0.8

Cum

ALL

C95

C91

C90

C75

C73

C67

C64

C61

C60

C56

C55

C54

C53

C50

C46

C44

C32

C25

C17

C16

C15

C11

C09

C00

C18

O&U

ICD-10

C92-94

C33-34

C19-20

C12-13

C03-06

C01-02

C07-08

C47,C49

C22,C24

C82-85,C96

Male

6.4

2.3

1.1

1.7

2.2

0.0

3.4

1.7

3.7

0.9

0.0

2.3

1.0

0.0

4.3

2.6

5.3

2.1

1.2

1.0

1.7

2.0

4.0

0.0

0.8

13.3

11.5

13.0

11.2

103.3

ASRWorld

6.3

1.3

2.5

1.3

2.5

0.0

1.3

0.0

2.5

1.3

0.0

5.0

2.5

1.3

2.5

0.0

3.8

8.8

11.3

13.9

103.3

CrudeRate

0.0

75+

61.9

990.9

123.9

185.8

0.0

70-

90.2

451.2

180.5

2015) by Age by Group 2015)

0.0

65-

–

69.8

139.5

418.5

3 3

0.0

60-

43.7

393.3

131.1

0.0

55-

28.7

315.6

143.5

0.0

50-

19.7

256.7

118.5

0.0

45-

14.4

28.8

115.2

0.0

40-

66.1

13.2

0.0

35-

39.1

13.0

0.0

30-

27.4

13.7

0.0

25-

36.4

18.2

0.0

20-

37.2

18.6

0.0

15-

0.0

10-

(2014), Mean annual ASR per annual (20100,000(2014), Mean

0.0

Year

No.Case

Nikhom Patthana Nikhom

11.3

Table Table

Allsites

Otherunspecified and

Leukemia unspecified Leukemia

Myeloidleukemia

Lymphoidleukemia

Multiplemyeloma

Non-Hodgkinlymphoma

Otherendocrine

Thyroid

Bladder

Kidney

Prostate

Penis

Ovary

Uterusunspecified

Corpusuteri

Cervixuteri

Breast

Connectivetissue

Kaposi'ssarcoma

Otherskin

Trachea, Bronchus and lung and Bronchus Trachea,

Larynx

Pancreas

Liverbile and duct

Rectum

Colon

Smallintestine

Stomach

Oesophagus

Hypopharynx

Nasopharynx

Tonsil

Salivaryglands

Mouth

Tongue

Lip Site

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Districts : Nikhom Patthana

Cancer Incidence in Rayong, Thailand, 2013-2015

0.1

0.0

0.3

0.1

0.3

0.2

0.1

0.9

0.0

0.1

0.0

0.3

0.5

0.1

2.4

2.3

0.0

0.1

0.9

0.0

0.2

0.7

1.6

0.0

0.1

0.0

0.2

0.0

12.1

Rate

7.5

0.1

0.0

0.3

0.1

0.0

0.2

0.1

0.9

0.0

0.1

0.0

0.3

0.2

0.1

0.9

1.9

0.0

0.1

0.7

0.0

0.2

0.4

0.0

0.1

0.0

0.2

0.0

Cum

ALL

C95

C91

C90

C75

C73

C67

C64

C61

C60

C56

C55

C54

C53

C50

C46

C44

C32

C25

C17

C16

C15

C11

C09

C00

C18

ale

O&U

ICD-10

C92-94

C33-34

C19-20

C12-13

C03-06

C01-02

C07-08

C47,C49

C22,C24

C82-85,C96

Fem

1.0

0.0

3.2

1.7

1.5

1.7

9.5

0.0

3.7

3.2

0.0

0.9

9.2

0.0

2.1

6.2

5.6

9.9

0.0

0.9

0.0

2.7

0.0

0.9

0.8

17.7

23.8

107.7

ASRWorld

1.3

0.0

2.6

1.3

0.0

1.3

0.0

5.1

2.6

1.3

0.0

1.3

0.0

2.6

6.4

9.0

0.0

1.3

0.0

3.9

0.0

1.3

11.6

19.3

30.9

10.3

123.5

CrudeRate

0.0

75+

92.3

46.1

322.9

0.0

70-

76.4

305.7

2015) by Age by Group 2015)

0.0

65-

55.2

–

607.0

220.7

165.5

3 3

0.0

60-

75.5

37.8

302.1

0.0

55-

57.5

28.7

316.0

0.0

50-

19.9

39.9

19.9

59.8

279.2

0.0

45-

92.5

15.4

30.8

185.0

0.0

40-

14.4

86.4

28.8

172.8

0.0

35-

41.4

27.6

41.4

13.8

138.1

0.0

30-

41.7

13.9

0.0

25-

16.6

0.0

20-

17.4

0.0

15-

36.8

18.4

0.0

10-

(2014), Mean annual ASR per annual (20100,000(2014), Mean

0.0

Year

No.Case

Nikhom Patthana Nikhom

11.4

Allsites

Otherunspecified and

Leukemia unspecified Leukemia

Myeloidleukemia

Lymphoidleukemia

Multiplemyeloma

Non-Hodgkinlymphoma

Otherendocrine

Thyroid

Bladder

Kidney

Prostate

Penis

Ovary

Uterusunspecified

Corpusuteri

Cervixuteri

Breast

Connectivetissue

Kaposi'ssarcoma

Otherskin

Trachea, Bronchus and lung and Bronchus Trachea,

Larynx

Pancreas

Liverbile and duct

Rectum

Colon

Smallintestine

Stomach

Oesophagus

Hypopharynx

Nasopharynx

Tonsil

Salivaryglands

Mouth

Tongue

Lip

Site Table Table

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The Incidence of common cancers Cancer Incidence in Rayong, Thailand, 2013-2015

The incidence of common cancers

The district with the highest rate for lung cancer incidence in males was Ban Chang District, ASR 28.5, the lowest incidence was Wang Chan District, ASR 12.8 and the districts with the highest incidence in females was Pluak Daeng District, ASR 15.2, the lowest incidence was Khao Chamao District, ASR 7.3.

The district with the highest rate for liver cancer incidence in males was Klaeng District, ASR 24.4, the lowest incidence was Nikhom Patthana District, ASR 11.5 and the district with the highest incidence in females was Ban Chang District, ASR 17.1, the lowest incidence was Khao Chamao District, ASR 2.3.

The district with the highest rate for colorectal cancer incidence in males was Pluak Daeng District, ASR 23.8, the lowest incidence was Khao Chamao District, ASR 3.7 and the districts with the highest incidence in females was Nikhom Patthana District, ASR 15.4, the lowest incidence was Khao Chamao District, ASR 1.8.

The district with the highest rate for breast cancer incidence in males was Ban Chang District, ASR 38.6 and the lowest incidence was Ban Khai District, ASR 19.4.

The district with the highest rate for cervical cancer incidence in males was Pluak Daeng District, ASR 20.3 and the lowest incidence was Wang Chan District, ASR 8.4.

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Lung Cancer Cancer Incidence in Rayong, Thailand, 2013-2015

Table 12.1 Lung cancer incidence, Mean annual ASR per 100,000 (2013 – 2015) by District – Male

No. District Code Districct Crude rate ASR 1 2102 Ban Chang 28.9 28.5 2 2107 Khao Chamao 24.7 22.4 3 2101 Mueang Rayong 21.3 22.2 4 2106 Pluak Daeng 14.6 17.5 5 2105 Ban Khai 22.7 17.3 6 2103 Klaeng 21.5 15.9 7 2108 Nikhom Patthana 11.3 13.3 8 2104 Wang Chan 16.5 12.8 All of the province 21.0 21.3

Figure 12.1 Mean annual Lung cancer incidence in Rayong (2013 – 2015), Male

Very incidence Medium incidence Less incidence

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Lung Cancer Cancer Incidence in Rayong, Thailand, 2013-2015

Table 12.2 Lung cancer incidence, Mean annual ASR per 100,000 (2013 – 2015) by District – Female

No. District Code District Crude rate ASR 1 2106 Pluak Daeng 15.5 15.2 2 2103 Klaeng 19.4 13.2 3 2101 Mueang Rayong 14.9 12.8 4 2102 Ban Chang 14.2 12.7 5 2104 Wang Chan 15.0 11.5 6 2108 Nikhom Patthana 10.3 9.2 7 2105 Ban Khai 12.6 7.8 8 2107 Khao Chamao 9.4 7.3 All of the province 15.0 12.6

Figure 12.2 Mean annual Lung cancer incidence in Rayong (2013 – 2015), Female

Very incidence Medium incidence Less incidence

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Liver Cancer Cancer Incidence in Rayong, Thailand, 2013-2015

Table 13.1 Liver cancer incidence, Mean annual ASR per 100,000 (2013 – 2015) by District – Male

No. District Code Districct Crude rate ASR 1 2103 Klaeng 31.3 24.4 2 2106 Pluak Daeng 17.5 17.6 3 2101 Mueang Rayong 15.9 15.5 4 2107 Khao Chamao 17.9 15.3 5 2102 Ban Chang 15.3 14.9 6 2104 Wang Chan 16.5 13.7 7 2105 Ban Khai 16.8 12.8 8 2108 Nikhom Patthana 13.9 11.5 All of the province 18.5 17.3

Figure 13.1 Mean annual Liver cancer incidence in Rayong (2013 – 2015), Male

Very incidence Medium incidence Less incidence 79 | P a g e

Liver Cancer Cancer Incidence in Rayong, Thailand, 2013-2015

Table 13.2 Liver cancer incidence, Mean annual ASR per 100,000 (2013 – 2015) by District – Female

No. District Code District Crude rate ASR 1 2102 Ban Chang 17.5 17.1 2 2106 Pluak Daeng 13.5 13.9 3 2108 Nikhom Patthana 6.4 6.2 4 2101 Mueang Rayong 6.8 5.9 5 2105 Ban Khai 7.6 5.8 6 2103 Klaeng 8.2 5.6 7 2104 Wang Chan 6.4 4.9 8 2107 Khao Chamao 2.4 2.3 All of the province 8.5 7.4

Figure 13.2 Mean annual Liver cancer incidence in Rayong (2013 – 2015), Female

Very incidence Medium incidence Less incidence

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Colorectal Cancer Cancer Incidence in Rayong, Thailand, 2013-2015

Table 14.1 Colorectal cancer incidence, Mean annual ASR per 100,000 (2013 – 2015) by District – Male

No. District Code Districct Crude rate ASR 1 2106 Pluak Daeng 19.5 23.8 2 2104 Wang Chan 28.9 22.6 3 2108 Nikhom Patthana 17.6 18.4 4 2102 Ban Chang 16.9 16.2 5 2101 Mueang Rayong 15.3 16.1 6 2103 Klaeng 16.6 13.2 7 2105 Ban Khai 16.8 12.6 8 2107 Khao Chamao 4.5 3.7 All of the province 16.4 16.6

Figure 14.1 Mean annual Colorectal cancer incidence in Rayong (2013 – 2015), Male

Very incidence Medium incidence

Less incidence

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Colorectal Cancer Cancer Incidence in Rayong, Thailand, 2013-2015

Table 14.2 Colorectal cancer incidence, Mean annual ASR per 100,000 (2013 – 2015) by District – Female

No. District Code District Crude rate ASR 1 2108 Nikhom Patthana 15.4 15.4 2 2102 Ban Chang 16.7 12.9 3 2101 Mueang Rayong 13.4 11.5 4 2103 Klaeng 14.5 9.9 5 2106 Pluak Daeng 9.3 8.1 6 2104 Wang Chan 8.5 7.1 7 2105 Ban Khai 9.3 5.5 8 2107 Khao Chamao 2.4 1.8 All of the province 8.5 10.4

Figure 14.2 Mean annual Colorectal cancer incidence in Rayong (2013 – 2015), Femal

Very incidence Medium incidence Less incidence

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ColorectalBreast Cancer Cancer Incidence in Rayong, Thailand, 2013-2015

Table 15 Breast cancer incidence, Mean annual ASR per 100,000 (2013 – 2015)

by District – Female

No. District Code District Crude rate ASR 1 2102 Ban Chang 47.6 38.6 2 2104 Wang Chan 49.1 36.9 3 2103 Klaeng 50.8 35.3 4 2101 Mueang Rayong 39.4 31.2 5 2108 Nikhom Patthana 30.9 23.8 6 2106 Pluak Daeng 25.9 23.3 7 2107 Khao Chamao 28.3 22.3 8 2105 Ban Khai 27.0 19.4 All of the province 39.3 30.4

Figure 15 Mean annual Breast cancer incidence in Rayong (2013 – 2015), Female

Very incidence Medium incidence Less incidence

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Cervical Cancer Cancer Incidence in Rayong, Thailand, 2013-2015 Table 16 Cervical cancer incidence, Mean annual ASR per 100,000 (2013 – 2015) by District – Female

No. District Code District Crude rate ASR 1 2106 Pluak Daeng 22.8 20.3 2 2103 Klaeng 27.1 19.4 3 2108 Nikhom Patthana 19.3 17.7 4 2102 Ban Chang 22.6 16.8 5 2101 Mueang Rayong 15.9 13.0 6 2107 Khao Chamao 14.2 9.2 7 2105 Ban Khai 12.6 8.5 8 2104 Wang Chan 10.7 8.4 All of the province 18.6 14.6

Figure 16 Mean annual Cervical cancer incidence in Rayong (2013 – 2015), Female

Very incidence Medium incidence Less incidence

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References Cancer Incidence in Rayong, Thailand, 2013-2015

References

Doll, R., Payne, P., Waterhouse, J.A.H. eds (1966). Cancer Incidence in Five Continents, Vol. I. Union Internationale Contre le Cancer, Geneva. Fritz, A., Percy, C., Jack, A., Shanmugaratnam, K., Sobin, L., Parkin, D.M., and Whelan, S. (2000). International Classification of Diseases for Oncology (ICD-O). Third Edition. Geneva: World Health Organization. Imsamran, W., Chaiwerawattana, A., Wiangnon, S., Suwanrungruang, K., Sangrajrang, S., and Buasom, R. (2018). Cancer in Thailand, Vol.IX, 2013-2015. National Cancer Institute, Ministry of Public Health, Thailand. Jensen, O.M., Parkin, D.M., Maclennan, R., Muir, C.S., and Skeet, R.G. (1991). Cancer Registration: Principles and Methods, (IARC Scientific Publications No 95). Lyon, France. Office of the National Economic and Social Development Board. (2013). Population Projection report for Thailand 2010-2040. Bangkok: Office of the National Economic and Social Development Board. Sobin, L., Gospodarowicz, M., and Wittekind, C. (2010). TNM Classification of Malignant Tumours. Seventh Edition. International Union Against Cancer: Wiley-Blackwell. The Bureau of Registration Administration Department of Provincial Administration. (2021). Official Statistics Registration System. Retrieved 28 January 2021, from https://stat.bora.dopa.go.th/stat/statnew/statyear/#/FilterPageAge. Thepsuwan K., Martin N., Tanabodee J., Pattatang A., and Onprom N. (2012). Cancer Incidence and Mortality in Rayong, Thailand, Volume I, 2003-2007. Chonburi Cancer Center, Ministry of Public Health, Thailand. Thepsuwan K. and Tanabodee J. (2015). CANCER INCIDENCE IN EASTERN REGION, THAILAND 2003-2007. Chonburi Cancer Center, Ministry of Public Health, Thailand.

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