Assessment of Neuraxial Blockade Level Differential Blockade Occurs Due to Anatomy and the Mechanism of Action of Local Anesthetics
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Herpes Zoster by Lesia Dropulic, MD
Herpes Zoster Lesia Dropulic Jeffrey Cohen Laboratory of Infectious Diseases, NIAID Varicella (Chickenpox) Centers for Disease Control and Prevention Zoster (Shingles) Centers for Disease Control and Prevention Zoster is Due to Reactivation of Varicella from the Nervous System Blood Adapted from Kimberlin and Whitley NEJM 2007 VZV DNA is Present In Neurons in Ganglia Years After Chickenpox Ganglia latently infected with VZV Subject No. Neurons No. (%) neurons Median VZV DNA Number Tested positive for VZV copies/positive cell Wang et al J Virol 2005 History of Zoster • Zoster: Greek for girdle • Shingles: Latin (cingere) girdle Partial encircling of the trunk with rash First Cell Culture of Varicella-Zoster Virus (March 19, 1949) Thomas Weller in Varicella-Zoster Virus, Cambridge Press 2000 Varicella- Zoster Virus Straus et al. Ann Intern Med 1988 Epidemiology of Zoster • About 99% of adults >40 yo infected with varicella-zoster, thus all older adults at risk • About 1 million cases in the US each year • Rates appear to be increasing • 50% of persons of live to age 85 will develop zoster, 5% may get a second case Risk Factors for Zoster • Age- the major risk factor for healthy persons (long duration since exposure to virus) • Immune compromise- T cell immunity: transplant recipients, leukemia, lymphoma; HIV increases the risk up to 50 fold • Age and immune compromise- reduced VZV-specific T cell immunity Varicella-Zoster Virus: Site of Latency • Varicella-zoster virus is latent in dorsal root ganglia (along the spine) or cranial nerve -
The Neuroanatomy of Female Pelvic Pain
Chapter 2 The Neuroanatomy of Female Pelvic Pain Frank H. Willard and Mark D. Schuenke Introduction The female pelvis is innervated through primary afferent fi bers that course in nerves related to both the somatic and autonomic nervous systems. The somatic pelvis includes the bony pelvis, its ligaments, and its surrounding skeletal muscle of the urogenital and anal triangles, whereas the visceral pelvis includes the endopelvic fascial lining of the levator ani and the organ systems that it surrounds such as the rectum, reproductive organs, and urinary bladder. Uncovering the origin of pelvic pain patterns created by the convergence of these two separate primary afferent fi ber systems – somatic and visceral – on common neuronal circuitry in the sacral and thoracolumbar spinal cord can be a very dif fi cult process. Diagnosing these blended somatovisceral pelvic pain patterns in the female is further complicated by the strong descending signals from the cerebrum and brainstem to the dorsal horn neurons that can signi fi cantly modulate the perception of pain. These descending systems are themselves signi fi cantly in fl uenced by both the physiological (such as hormonal) and psychological (such as emotional) states of the individual further distorting the intensity, quality, and localization of pain from the pelvis. The interpretation of pelvic pain patterns requires a sound knowledge of the innervation of somatic and visceral pelvic structures coupled with an understand- ing of the interactions occurring in the dorsal horn of the lower spinal cord as well as in the brainstem and forebrain. This review will examine the somatic and vis- ceral innervation of the major structures and organ systems in and around the female pelvis. -
The Use of Remifentanil As the Primary Agent for Analgesia in Parturients
The Use Of Remifentanil As The Primary Agent For Analgesia In Parturients Author: Bryan Clifford Anderson, DNAP, CRNA Learning Objectives for this Self Study: The Importance of Exploring Remifentanil as an Upon completion of this study, the CRNA will be able to: Option for Treating Labor Pain The use of remifentanil in the parturient as the primary analgesic is 1. Discuss the significance of remifentanil use as a primary analgesic significant for several reasons; the most salient of which is the basic human agent in parturients for whom neuraxial anesthesia is not an option. right to the management of pain. Pain, as defined by the International Association for the Study of Pain (IASP), is “an unpleasant sensory and 2. Identify clients in which neuraxial anesthesia might be contraindicated. emotional experience associated with actual or potential tissue damage.” 2 Labor is a cause of severe pain for many women and is a problem that should 3. Compare the efficacy of select medications in the control of pain be addressed and managed in accordance with the needs and wishes of the in paturients. individual patient. Interventions that alleviate or eliminate pain are not merely a matter of beneficence, but also form part of the duty to prevent harm.3 4. Appraise findings in current evidence to determine to what extent The variations in pain perception among women in labor creates an essential remifentamil is a viable option for pain management in parturient patients. component in the administration of anesthesia in the provision of patient- centered anesthesia care. One recent study identifies that the perception of 5. -
Disc Pathology Lumbar Dermatomes
Lumbar Dermatomes: Disc Pathology Lumbar Dermatomes In this example, nerve root pain is due to disc pathology. Dermatomes are regions of altered sensation from irritated or damaged nerve roots. Symptoms that follow a dermatome (numbness, tingling or pain) may indicate a pathology that involves the related nerve root. These symptoms can follow the entire dermatome or just part of it. When symptoms cover more than one dermatome it may suggest more severe pathology and involvement of more than one nerve root. Disc Pathology: Lumbar Disc Pathology has various presentations. 1. Normal Disc 2. Internal Disc Disorder: Small tear at the inner part of the outer third of the disc where the annulus is innervated. 3. Outer Disc Disorder: Larger tear that extends to the outer part of the annulus. Discography is a good way to diagnose the morphology of the disc and establish the disc as a pain generator. 4. Protrusion: Small disc bulge and the outer layers of the annulus are intact 5. Prolapse: Large disc bulge that breaks through the layers of the annulus but not the posterior longitudinal ligament (PLL). 6. Extrusion: Large disc bulge that breaks through the layers of the annulus and the PLL. This often causes pain in a multitude of dermatomes. 7. Sequestration (not shown; rare): Disc fragment breaks away from the rest of the discs. 1. Sizer PS Jr, Phelps V, Matthijs O. Pain generators of the lumbar spine. Pain Pract. 2001;1(3):255‐ 273. 2. Sizer PS Jr, Phelps V, Dedrick G, Matthijs O. Differential diagnosis and management of spinal nerve root‐related pain. -
Unit #2 - Abdomen, Pelvis and Perineum
UNIT #2 - ABDOMEN, PELVIS AND PERINEUM 1 UNIT #2 - ABDOMEN, PELVIS AND PERINEUM Reading Gray’s Anatomy for Students (GAFS), Chapters 4-5 Gray’s Dissection Guide for Human Anatomy (GDGHA), Labs 10-17 Unit #2- Abdomen, Pelvis, and Perineum G08- Overview of the Abdomen and Anterior Abdominal Wall (Dr. Albertine) G09A- Peritoneum, GI System Overview and Foregut (Dr. Albertine) G09B- Arteries, Veins, and Lymphatics of the GI System (Dr. Albertine) G10A- Midgut and Hindgut (Dr. Albertine) G10B- Innervation of the GI Tract and Osteology of the Pelvis (Dr. Albertine) G11- Posterior Abdominal Wall (Dr. Albertine) G12- Gluteal Region, Perineum Related to the Ischioanal Fossa (Dr. Albertine) G13- Urogenital Triangle (Dr. Albertine) G14A- Female Reproductive System (Dr. Albertine) G14B- Male Reproductive System (Dr. Albertine) 2 G08: Overview of the Abdomen and Anterior Abdominal Wall (Dr. Albertine) At the end of this lecture, students should be able to master the following: 1) Overview a) Identify the functions of the anterior abdominal wall b) Describe the boundaries of the anterior abdominal wall 2) Surface Anatomy a) Locate and describe the following surface landmarks: xiphoid process, costal margin, 9th costal cartilage, iliac crest, pubic tubercle, umbilicus 3 3) Planes and Divisions a) Identify and describe the following planes of the abdomen: transpyloric, transumbilical, subcostal, transtu- bercular, and midclavicular b) Describe the 9 zones created by the subcostal, transtubercular, and midclavicular planes c) Describe the 4 quadrants created -
Pediatric Neuraxial Blockade
University of Massachusetts Medical School eScholarship@UMMS Anesthesiology and Perioperative Medicine Publications Anesthesiology and Perioperative Medicine 1993-7 Pediatric neuraxial blockade John Pullerits University of Massachusetts Medical School Et al. Let us know how access to this document benefits ou.y Follow this and additional works at: https://escholarship.umassmed.edu/anesthesiology_pubs Part of the Anesthesiology Commons Repository Citation Pullerits J, Holzman RS. (1993). Pediatric neuraxial blockade. Anesthesiology and Perioperative Medicine Publications. https://doi.org/10.1016/0952-8180(93)90131-W. Retrieved from https://escholarship.umassmed.edu/anesthesiology_pubs/82 This material is brought to you by eScholarship@UMMS. It has been accepted for inclusion in Anesthesiology and Perioperative Medicine Publications by an authorized administrator of eScholarship@UMMS. For more information, please contact [email protected]. Pediatric Neuraxial Blockade John Pullerits, MD, FRCPC,* Robert S. Holzman, MD? Department of Anesthesiology, University of Massachusetts Medical Center, Worcester, MA, and Department of Anesthesia, Children’s Hospital, Boston, MA. Regional anesthetic techniques for children have recently enjoyed Historical Perspective a justified resurgence in popularity. Intraoperative blockade of August Bier’s investigation of spinal anesthesia in Ger- the neuraxis, whether by the spinal or epidural route, provides many’ and Siccard’s* and Cathelin’$ studies of caudal excellent analgesia with minimal physiologic -
Dermatomal Distribution | Definition of Dermatomal Distribution by Medical
10/13/2016 Dermatomal distribution | definition of dermatomal distribution by Medical dictionary Dermatomal distribution | definition of dermatomal distribution by Medical dictionary http://medicaldictionary.thefreedictionary.com/dermatomal+distribution dermatome (redirected from dermatomal distribution) Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia. dermatome [der´mah-tōm] 1. the area of skin supplied with afferent nerve fibers by a single posterior spinal root. 2. the lateral part of an embryonic somite. 3. an instrument for removing splitthickness skin grafts from donor sites; there are many different kinds, divided into three major types: knife, drum, and motordriven. Dermatomes. Segmental dermatome distribution of spinal nerves to the front, back, and side of the body. C, Cervical segments; T, thoracic segments; L, lumbar segments; S, sacral segments; CX, coccygeal segment. Dermatomes are specific skin surface areas innervated by a single spinal nerve or group of spinal nerves. Dermatome assessment is done to determine the level of spinal anesthesia for surgical procedures and postoperative analgesia when epidural local anesthetics are used. From Thibodeau and Patton, 1999. drum dermatome a dermatome consisting of a cylindrical drumlike apparatus coated with adhesive that rolls over the skin while a blade moves across the surface and cuts the graft free. knife dermatome the simplest type of dermatome, which is used to remove grafts by a freehand technique. motordriven dermatome a dermatome driven by a power source; motordriven dermatomes cut with a backandforth blade action. MillerKeane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. -
SOAP Thrombocytopenia Consensus Statement FINAL
The Society for Obstetric Anesthesia and Perinatology Interdisciplinary Consensus Statement on Neuraxial Procedures in Obstetric Patients with Thrombocytopenia Melissa E. Bauer DO1, Katherine Arendt MD2, Yaakov Beilin MD3, Terry Gernsheimer MD4, Juliana Perez Botero MD5, Andra H. James MD6, Edward Yaghmour MD7, Roulhac D. Toledano MD, PhD8, Mark Turrentine MD9, Timothy Houle PhD10, Mark MacEachern MLIS11, Hannah Madden, BS10, Anita Rajasekhar, MD MS12, Scott Segal MD13, Christopher Wu MD14, Jason P. Cooper MD, PhD4, Ruth Landau MD15, Lisa Leffert, MD10 1Department of Anesthesiology, University of Michigan 2Department of Anesthesiology and Perioperative Medicine, Mayo-Clinic 3Department of Anesthesiology, Perioperative and Pain Medicine, and Obstetrics Gynecology and Reproductive Sciences Icahn School of Medicine at Mount Sinai 4Department of Medicine, University of Washington School of Medicine 5Department of Medicine, Medical College of Wisconsin and Versiti 6Department of Obstetrics and Gynecology, Duke University 7Department of Anesthesiology, Vanderbilt University 8Department of Anesthesiology, Perioperative Care, and Pain Medicine, NYU Langone Health 9Department of Obstetrics and Gynecology, Baylor College of Medicine. Liaison for the American College of Obstetricians and Gynecologists 10Department of Anesthesiology, Massachusetts General Hospital 11Taubman Health Sciences Library, University of Michigan 2 12Department of Medicine, University of Florida 13Department of Anesthesiology, Wake Forest University School of Medicine 14Department -
Anesthesia: Essays and (KSA) for Entire Editorial Board Visit : Researches
A E R Editor‑in‑Chief : Open Access Mohamad Said Maani Takrouri HTML Format Anesthesia: Essays and (KSA) For entire Editorial Board visit : http://www.aeronline.org/editorialboard.asp Researches Original Article Efficacy of intrathecal midazolam in potentiating the analgesic effect of intrathecal fentanyl in patients undergoing lower limb surgery Anshu Gupta, Hemlata Kamat1, Utpala Kharod1 Departments of Anaesthesia, Lady Hardinge Medical College, New Delhi, 1Pramukhswami Medical College, Anand, Gujarat, India Corresponding author: Dr. Anshu Gupta, Department of Anaesthesia, Lady Hardinge Medical College, New Delhi, India. E‑mail: [email protected] Abstract Introduction: The intrathecal administration of combination of drugs has a synergistic effect on the subarachnoid block characteristics. This study was designed to study the efficacy of intrathecal midazolam in potentiating the analgesic duration of fentanyl along with prolonged sensorimotor blockade. Materials and Methods: In a double‑blind study design, 75 adult patients were randomly divided into three groups: Group B, 3 ml of 0.5% hyperbaric bupivacaine; Group BF, 3 ml of 0.5% hyperbaric bupivacaine + 25 mcg of fentanyl; and Group BFM, 3 ml of 0.5% hyperbaric bupivacaine + 25 mcg of fentanyl + 1 mg of midazolam. Postoperative analgesia was assessed using visual analog scale scores and onset and duration of sensory and the motor blockade was recorded. Results: Mean duration of analgesia in Group B was 211.60 ± 16.12 min, in Group BF 420.80 ± 32.39 min and in Group BFM, it was 470.68 ± 37.51 min. There was statistically significant difference in duration of analgesia between Group B and BF ( P = 0.000), between Group B and BFM (P = 0.000), and between Group BF and BFM (P = 0.000). -
Assessment of the Sympathetic Level of Lesion in Patients with Spinal Cord Injury
Spinal Cord (2009) 47, 122–127 & 2009 International Spinal Cord Society All rights reserved 1362-4393/09 $32.00 www.nature.com/sc ORIGINAL ARTICLE Assessment of the sympathetic level of lesion in patients with spinal cord injury JG Previnaire1, JM Soler2, W El Masri3 and P Denys4 1Spinal Department, Centre Calve´, Fondation Hopale, Berck sur Mer, France; 2Laboratoire d’urodynamique et de sexologie, Centre Bouffard Vercelli, Cerbe`re, France; 3Midlands Centre for Spinal Injuries, RJ and AH Orthopaedic Hospital, Shropshire, UK and 4Service de Re´e´ducation Neurologique, Hoˆpital Raymond Poincare´, Garches, France Study design: To study the vasomotor responses (skin axon-reflex vasodilatation (SkARV) to stimulation of the skin in spinal cord injury (SCI) patients. Objective: To assess the completeness of the sympathetic injury and to define the sympathetic level of lesion in paraplegic and tetraplegic patients. Setting: Centre Calve, Fondation Hopale and Centre Bouffard-Vercelli, France. Subjects: A total of 81 SCI patients ranging from C2 to L2. Method: A mechanical stimulation was applied to the skin on both sides of the trunk, using a blunt instrument. The presence of an abnormal response below the lesion helped define the sympathetic level. Results: Above the lesion, SkARV was observed in all patients. In patients with a complete sympathetic injury, the response below the lesion was either a vasoconstrictor response in upper motor neuron lesions, or total absence of SkARV in lower motor neuron lesions. There was excellent correspondence between complete somatic (American Spinal Injury Association (ASIA) A) and complete sympathetic lesions (100% of paraplegic and 94% of tetraplegic patients), whereas an incomplete somatic (ASIA B– D) lesion was often associated with a complete sympathetic lesion. -
Complications of Neuraxial Blockade
Complications of Neuraxial Blockade Several complications are associated with neuraxial blockade. Complications can be divided into several categories and include: exaggerated physiological responses, needle/catheter placement, and medication toxicity. Overall there is a low incidence of serious complications related to the administration of neuraxial blockade. However, complications may be temporary or permanent. Use of epidural anesthesia may have a higher incidence of complications when compared to spinal anesthesia. The patient population most affected is obstetrics. Adverse or Exaggerated Physiological Responses This category includes high neural blockade, cardiac arrest, and urinary retention. As noted earlier, there are normal physiologic manifestations that occur with neuraxial blockade. Vigilance, knowledge, preparation, and anticipation can reduce complications. High Neural Blockade High neural blockade can occur with either epidural or spinal anesthesia. This complication may be due to the administration of excessive doses of local anesthetic, failure to reduce doses in patients susceptible to excessive spread (i.e. elderly, pregnant, obese, or short patients), increased sensitivity, and excessive spread. When dosing a spinal or epidural, it is important to monitor the patients’ vital signs and block level. Use of alcohol wipes as well as pin prick testing every few minutes will help track the blocks progression. Incremental dosing of epidurals allows the anesthesia provider to determine if the block is progressing more rapidly than anticipated. With hyperbaric spinal techniques, changing the patients’ position may slow down excessive spread. Prevention is based on careful consideration in the dosing of the neuraxial block, anticipation of potential complications, and continual monitoring of the blocks progression. Initial symptoms include the following: dyspnea numbness or weakness of the upper extremities (i.e. -
Entrapment Neuropathy
Limb Weakness: Radiculopathies and Compressive Disorders Spot the brain cell Dr. Theo Mobach PGY-4 Neurology [email protected] Image: Felten, Shetty. Netter’s Atlas of Neuroscience. 2nd Edition. Objectives • Basic neuroanatomy of peripheral nervous system • Physical exam: motor and sensory components • Common entrapment neuropathies – Median Neuropathy at the Wrist – Ulnar Neuropathy at the Elbow – Fibular Neuropathy • Radiculopathies UMN vs LMN Upper Motor Neuron Lower Motor Neuron • Spasticity • Atrophy • Hyperreflexia • Hypotonia • Pyramidal pattern • Decreased or of weakness absent reflexes • Babinski sign • Fasciculation's Motor Unit Motor neuron Skeletal Muscle Fibers Often several motor units work together to coordinate contraction of a single muscle Spinal Roots Image: Olson, Pawlina. Student Atlas of Anatomy. 2nd Edition Image: Olson, Pawlina. Student Atlas of Anatomy. 2nd Edition Dermatome Definition: A sensory region of skin innervated by a nerve root = dermatome Image: Felten, Shetty. Netter’s Atlas of Neuroscience. 2nd Edition. Sensory Innervation Cutaneous Nerve Branches Images: Felten, Shetty. Netter’s Atlas of Neuroscience. 2nd Edition. Nerve Muscle Peripheral Nerve Root Myotome C5 Deltoids Axillary N. Infraspinatus Suprascapular N. Biceps Musculocutaneous Definition: C6 Biceps Musculocutaneous Wrist extensors (ECR) Radial N. C7 Triceps Radial N. Muscles Finger extensors (EDC) PIN (Radial N.) innervated C8 Extensor indicis proprius (EIP) PIN (Radial N.) Median innervated intrinsic Median by a single hand muscles (LOAF) nerve root = L4 Quadriceps Femoral L5 Foot dorsiflexion Fibular N. myotome Foot inversion Fibular N. Foot eversion Tibial N. Hip abduction Gluteal N. S1 Foot plantar flexion, Tibial N. Hip extension Gluteal N. Recall • Write down 2 muscle for each of the following myotomes, the muscles MUST be from different peripheral nerves: – C6 – C8 – L5 – S1 Answer Nerve Muscle Peripheral Nerve Root C6 Biceps Musculocutaneous Wrist extensors (ECR) Radial N.