POSTERS WEDNESDAY, JUNE 12

POSTER SESSION HALLS 11.1, 11.2

10.00 - 12.00 WEDNESDAY Basic Science Inorganic ions W001-W034 Protein sorting / Epithelial polarity W035-W042 Extracellular mediators (cytokines, prostanoids, nucleotides, radicals, etc.) W043-W086 Extracellular matrix, fibrosis W087-W143 Renal haemodynamics, vascular physiology, vascular pathology, experimental hypertension W144-W188 Miscellaneous - Tubular cell function W189-W203 Miscellaneous - Arrays and proteonomics W204-W209 General Nephrology Primary glomerular diseases: clinical W210-W235 Vasculitides, systemic diseases: clinical W236-W252 Hypertension: clinical W253-W264 Hereditary renal diseases W265-W296 Clinical nephrology: miscellaneous W297-W331 Acute renal failure, toxic nephropathy W332-W389 Chronic renal failure: miscellaneous W390-W412 Calcium, magnesium, phosphate and phosphate binders W413-W439 Anaemia: miscellaneous W440-W457 Dialysis Cardiov. risk in ESRD, homocysteine W458-W483 Cardiov. risk in ESRD, cardiac hypertrophy and atherosclerosis W484-W515 Cardiovascular morbidity and mortality; lipids, inflammation and other predictors W516-W566 Vascular access W567-W622 ESRD treatment comparisons W623-W636 Haemodialysis: infections, cancer W637-W648 Haemofiltration, Haemodiafiltration and other modalities W649-W670 PD: Cardiov. morbidity and mortality W671-W679 PD: inflammation, nutrition W680-W697 PD: miscellaneous W698-W720 Transplantation Immunosuppression - clinical trials W721-W750 Immunosuppression – other W751-W763 Outcomes, cardiov. morbidity and mortality W764-W789 Miscellaneous W790-W805 Paediatric Nephrology Physiology W806-W814 Pathology W815-W817 Pharmacology W818-W822 Paediatric clinical nephrology, acute and chronic renal failure, bone and mineral metabolism, anaemia Miscellaneous W823-W846 Acute renal failure W847-W850 Paediatric dialysis Peritoneal dialysis W851-W866 Paediatric transplantation Infections W867-W873

355 WEDNESDAY, JUNE 12 POSTERS

BASIC SCIENCE INORGANIC IONS

W001 THE cAMP-INDUCED INCREASE IN Na,K-ATPase CELL SURFACE EXPRESSION IS INDEPENDENT OF THE PHOSPHORYLATION OF ITS ALPHA-SUBUNIT ON Ser-943 IN CULTURED COLLECTING DUCT PRINCIPAL CELLS David Mordasini,1 Marcelle Bens,2 Pierre-Yves Martin,1 Alain Vandewalle,2 Eric Feraille.1 1Division of Nephrology, University of Geneva, Geneva, Switzerland; 2INSERM U478, Faculté de Médecine Xavier Bichat, Paris, France

W002 EXPLORATION OF THE CATION PATHWAY THROUGH THE Na,K-ATPASE BY CYSTEINE SCANNING MUTAGENESIS: CONTRIBUTION OF THE 4TH TRANSMEMBRANE SEGMENT OF THE a SUBUNIT Jean-Daniel Horisberger,1 Solange Kharoubi-Hess,1 Saida Guennoun.2 1Institute of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland; 2Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, Newark, NJ, United States

W003 THE SKIN IS AN OSMOTICALLY- INACTIVE NA+ RESERVOIR THAT IS DIMINISHED IN DAHL RATS Jens Titze,1 Peter Dietsch,2 Karl-Heinz Schwind,3 Karl A. Kirsch,4 Karl F. Hilgers.1 1Nephrology, Friedrich-Alexander-Univ. Erlangen-Nürnberg, Erlangen, Germany; 2Biochemistry, Free Univ. Berlin, Germany; 3Chemistry and Physics, Federal Center for Meat Research, Kulmbach, Germany; 4Physiology, Free Univ.Berlin, Berlin, Germany

W004 OVARIECTOMY (OVX) LEADS TO AQUIRED INCAPACITY OF OSMOTICALLY-INACTIVE NA+ STORAGE IN SPRAGUE DAWLEY RATS Jens Titze,1 Mehdi Shakibaei,2 Peter Dietsch,3 Gundula Schulze- Tanzil,2 Karl A. Kirsch,4 Karl-Heinz Schwind,5 Karl F. Hilgers.1 1Nephrology, Friedrich Alexander University Erlangen-Nürnberg, Erlangen, Germany; 2Anatomy, Free University Berlin, Berlin, Germany; 3Biochemistry, Free University Berlin, Berlin, Germany; 4Physiology, Free University Berlin, Berlin, Germany; 5Chemistry & Physics, Federal Center for Meat Research, Kulmbach, Germany

W005 A SINGLE NUCLEOTIDE POLYMORPHISM THAT ALTERS THE ACTIVITY OF THE RENAL Na+:Cl- COTRANSPORTER Erika Moreno,1,2 Patricia Meade,1,2 Norma Vazquez,1,2 Gerardo Gamba.1,2 1Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Tlalpan, Mexico City, Mexico; 2Molecular Physiology Unit, Instituto de Investigaciones Biomedicas, UNAM, Tlalpan, Mexico City, Mexico

W006 NKCC1, THE SECRETORY Na+-K+-Cl- COTRANSPORTER, MEDIATES NH4+ AND Cl- UPTAKE DURING AMMONIUM- INDUCED FLUID SECRETION IN THE RAT INNER MEDULLARY COLLECTING DUCT Darren Wallace, Gail Reif, Anne-Marie Hedge, Jared Grantham. Kidney Institute, Univ. of Kansas Medical Center, Kansas City, KS, USA

W007 STIMULATION OF NEDD4-2 PHOSPHORYLATION AND TRANSEPITHELIAL NA-TRANSPORT BY ALDOSTERONE IN MPKCCDcl4 CELLS Sandra Y. Flores,1 Johannes Loffing,2 Olivier Staub.1 1Institute of Pharmacology & Toxicology, Univ.of Lausanne, Lausanne, Switzerland; 2Institute of Anatomy, Univ. of Zurich, Zurich, Switzerland

356 POSTERS WEDNESDAY, JUNE 12

W008 INACTIVATION OF ALPHA ENAC SUBUNIT FUNCTION IN THE COLLECTING DUCT Isabelle Rubera,1 Jan Loffing,2 Larry Palmer,3 Tom Carrol,4 Andy McMahon,4 Bernard Rossier,1 Edith Hummler.1 WEDNESDAY 1Fac Med, Inst Pharmacol & Toxicologie, Lausanne, Switzerland; 2Univ of Zurich, Inst.of Anatomy, Zurich, Switzerland; 3Dept of Physiology and Biophysics, New York, USA; 4Dept of Molecular and Cellular Biology, Cambridge, USA

W009 MUTATIONS IN THE OUTER PORE OF THE EPITHELIAL NA CHANNEL DISRUPT AMILORIDE BLOCK BY INCREASING THE OFF-RATE Stephan Kellenberger, Ivan Gautschi, Laurent Schild. Inst. de Pharmacologie et de Toxicologie, Univ. de Lausanne, Lausanne, VD, Switzerland

W010 TUBULAR SECRETION OF PHOSPHATE IN THE NORMAL RAT: EFFECT OF ANGIOTENSIN CONVERTING ENZYME INHIBITION Isabelle M. Renaud,1,2 Angele Chainey,2 Jacques Chevalier,1 Gerard E. Plante.2 1INSERM U430, Broussais Hospital, Paris, France; 2Pharmacology Institute, Sherbrooke University, Sherbrooke, QC, Canada

W011 APICAL TRANSLOCATION OF ROMK AND ENaC IN MOUSE DISTAL NEPHRON IN RESPONSE TO HIGH K+ DIET Dominique Loffing-Cueni,1 Martin Schlaepfer,1 May Bloch-Faure,3 Edith Hummler,2 Bernard Rossier,2 Brigitte Kaissling,1 Pierre Meneton,3 Johannes Loffing.1 1Institute of Anatomy, University of Zurich, Zurich, Switzerland; 2Institute of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland; 3INSERM U367, Paris, France

W012 DYSFUNCTION OF THE EPITHELIAL SODIUM CHANNEL (ENaC) EXPRESSED IN THE KIDNEY OF LIDDLE MICE Sylvain Pradervand,1 Alain Vandewalle,2 Marcelle Bens,2 Ivan Gautschi,1 Johannes Loffing,3 Edith Hummler,1 Laurent Schild,1 Bernard Rossier.1 1Inst. de Pharmacologie et de Toxicologie, Univ. de Lausanne, Lausanne, Vaud, Switzerland; 2U478, Fac. de Medecine Xavier Bichat, Paris, France; 3Anatomisches Inst., Univ. Zurich-Irchel, Zurich, Switzerland

W013 REGULATION OF EPITHELIAL NA+ CHANNELS IN A MOUSE MODEL OF LIDDLE’ S SYNDROM Anke Dahlmann,1 Edith Hummler,2 Sylvain Pradervand,2 Bernard Rossier,2 Gustavo Frindt,1 Lawrence G. Palmer.1 1Dept of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY, United States; 2Institut de Pharmacologie et de Toxicologie, Université de Lausanne, Lausanne, Switzerland

W014 THE EFFECT OF NACL ON LINGUAL SURFACE POTENTIALS AND THE ROLE OF AMILORIDE George Feldman,1 Gerard Heck,2 Vijay Lyall,2 Cecily Santos,1 Rebeca Clary,1 John DeSimone,2 Andras Mogyorosi.1 1Medicine, VCU School of Medicine and McGuire VAMC, Richmond, VA, USA; 2Physiology, VCU School of Medicine, Richmond, VA, USA

W015 MECHANISMS UNDERLYING THE REGULATION OF THE RENAL OUTER MEDULLARY K+ CHANNEL ROMK1 BY THE SERUM AND GLUCOCORTICOID INDUCIBLE KINASE SGK1 AND THE NA+/H+ EXCHANGER REGULATING FACTOR NHERF2 Monica Palmada,1 Hamdy M. Embark,1 Chris Yun,2 Edward J. Weinman,3 David Pearce,4 Christoph Boehmer,1 Florian Lang.1 1Dept Physiology, Eberhard-Karls-Univ, Tuebingen, Germany; 2Dept Medicine, Emory Univ, Atlanta, GA, USA; 3Dept Medicine, Univ Maryland, Baltimore, MD, USA; 4Dept Medicine, Univ California, San Francisco, CA, USA

357 WEDNESDAY, JUNE 12 POSTERS

W016 CONTRIBUTION OF THE INTRACELLULAR N-TERMINUS OF aENaC IN ITS FUNCTION AND STIMULATION BY ALDOSTERONE IN A CORTICAL COLLECTING DUCT CELL LINE Muriel Auberson, Laurent Schild. Institut de Pharmacologie et Toxicologie, Université de Lausanne, Lausanne, Vaud, Switzerland

W017 RENAL PHENOTYPE OF THE TWIK1 POTASSIUM CHANNEL KNOCKOUT MOUSE Richard Warth,1 Isabelle Arrighi,2 Raymond Mengual,2 Elisa Romeo,1 Francois Verrey,1 Jacques Barhanin.2 1Institute of Physiology, University of Zurich, Zurich, Switzerland; 2IPMC, CNRS, Sophia-Antipolis, France

W018 RENAL POTASSIUM EXCRETION IS IMPAIRED IN SGK1 DEFICIENT MICE Danyang Huang,1 Peer Wulff,2 Dietmar Kuhl,3 Florian Lang,4 Volker Vallon.1 1Institute of Pharmacology and Toxicology, University of Tuebingen, Tuebingen, Baden-Wuerttemberg, Germany; 2Clinic of Neurology, University of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany; 3Institute of Molecular Neurobiology, Free University of Berlin, Berlin, Germany; 4Institute of Physiology, University of Tuebingen, Tuebingen, Baden-Wuerttemberg, Germany

W019 ABSENCE OF INTERMEDIATE-CONDUCTANCE K CHANNEL (IK) IN THE APICAL MEMBRANE OF THICK ASCENDING LIMB (TAL) IN ROMK KNOCKOUT MICE Ming Lu, Qingshang Yan, Tong Wang, Steven Hebert, Gerhard Giebisch. Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, United States

W020 CHARACTERIZATION OF THE FUNCTION OF TWO NATURALLY OCCURRING MUTATIONS IN THE HUMAN SODIUM- PHOSPHATE COTRANSPORTER TYPE IIa Leila Virkki, Ian Forster, Jürg Biber, Heini Murer. Institute of Physiology, University of Zürich, Zürich, Switzerland

W021 ONTOGENY, PROCESSING AND SEGMENTAL DISTRIBUTION OF THE RENAL CHLORIDE CHANNEL ClC-5 Francois Jouret,1 Patricia D. Wilson,2 Rajesh V. Thakker,3 Olivier Devuyst.1 1Div. of Nephrology, Université Catholique de Louvain, Brussels, Belgium; 2Div. of Nephrology, Mount Sinai Medical School, New York, United States; 3Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom

W022 A COMMON SEQUENCE VARIATION OF THE CLCNKB GENE STRONGLY ACTIVATES CLC-KB CHLORIDE CHANNEL ACTIVITY Nikola Jeck, Petra Waldegger, Jolanta Doroszewicz, Hannsjoerg Seyberth, Siegfried Waldegger. Children’s Hospital, Philipps University of Marburg, Marburg, Germany

W023 THE PURINERGIC RECEPTOR P2Y1 REGULATES CFTR- DEPENDENT CHLORIDE EFFLUX IN A RENAL CELLULAR MODEL Lorenzo Guerra,1 Maria Favia,1 Anna Bagorda,1 Giuseppe Calamita,1 Maria Svelto,1 Teresa Fanelli,1 Kenneth A. Jacobson,2 Stephan J. Reshkin,1 Valeria Casavola.1 1Department of General and Environmental Physiology, University of Bari, Bari, Italy; 2Molecular Recognition Section, Laboratory of Biorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, MD, United States

358 POSTERS WEDNESDAY, JUNE 12

W024 MICRODISSECTION ANALYSIS OF CHLORIDE CHANNEL CLC- K1 AND BARTTIN mRNA EXPRESSION IN MEDULLA OF FUROSEMIDE TREATED RATS Konrad Wolf,1 Helga Vitzthum,2 Bernhard Krämer.1 WEDNESDAY 1Klinik und Poliklinik für Innere Medizin II, Klinikum der Universität Regensburg, Regensburg, Germany; 2Institut für Physiologie, Universität Regensburg, Regensburg, Germany

W025 REGULATION OF CLCKA/BARTTIN CL- CHANNELS BY THE UBIQUITIN LIGASE NEDD4-2 AND THE SERUM AND GLUCOCORTICOID INDUCIBLE KINASES SGK1 AND SGK3 Hamdy M. Embark,1 Christoph Boehmer,1 Giovambattista Capasso,2 Petra Waldegger,3 Siegfried Waldegger,3 Florian Lang.1 1Dept. of Physiology, University of Tuebingen, Tuebingen, Germany; 2Chair of Nephrology, Second University of Naples, Naples, Italy; 3Dept. of Pediatrics, University of Marburg, Marburg, Germany

W026 COLLECTING DUCTS OF HUMAN KIDNEY COEXPRESS THE SLC26A6 AND SLC26A7 ANION EXCHANGERS Minna Kujala,1 Jukka Tienari,2 Hannes Lohi,1 Eero Lehtonen,3 Juha Kere.1,4 1Department of Medical Genetics, Biomedicum, University of Helsinki, Helsinki, Finland; 2Department of Pathology, Helsinki University Central Hospital / Peijas Hospital, Vantaa, Finland; 3Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, CA, United States; 4Department of Biosciences at Novum, Karolinska Institute, Stockholm, Sweden

W027 REMODELING OF RAT DISTAL CONVOLUTED TUBULE UNDER PROLONGED THIAZIDE TREATMENT Johannes Loffing, Urs Jetzer, Dominique Loffing-Cueni, Helena Lagger Biner, Michel Le Hir, Brigitte Kaissling. Anatomical Institute, University of Zurich, Zurich, Switzerland

W028 HORMONAL REGULATION OF THE RENAL INORGANIC SODIUM PHOSPHATE-COTRANSPORTER (NAPI-2A) IN MEGALIN DEFICIENT MICE Thomas Petsch,1 Uwe Schlichting,1 Jan-Henning Fruehauf,1 Joerg Leheste,2 Heini Murer,3 Juerg Biber,3 Thomas Willnow,2 Sebastian Bachmann.1 1Anatomy, Charite, Humboldt-University, Berlin, Germany; 2Max- Delbrueck-Center for Molecular Medicine, Berlin, Germany; 3Physiology, University, Zuerich, Switzerland

W029 ADAPTATION OF RENAL AND INTESTINAL PHOSPHATE TRANSPORTERS NaPi-IIa AND IIb IN VITAMIN D RECEPTOR KNOCK-OUT MICE IS NORMAL Paola Capuano,1 Desa Bacic,1,2 Brigitte Kaissling,2 Carsten A. Wagner,1 Heini Murer,1 Juerg Biber.1 1Institute of Physiology, University of Zurich, Zurich, Switzerland; 2Institute of Anatomy, University of Zurich, Zurich, Switzerland

W030 MITOCHONDRIAL UPTAKE OF CYTOSOLIC CALCIUM DURING METABOLIC INHIBITION OF MDCK CELLS MIGHT BE ASCRIBED TO THE REVERSAL OF THE MITOCHONDRIAL Na+/ Ca2+ EXCHANGER Ilse Smets,1 Adrian Caplanusi,2 Sanda Despa,3 Zsolt Molnar,4 Mihai Radu,5 Martin vandeVen,1 Marcel Ameloot,1 Paul Steels.1 1Dept. Physiology, LUC/tUL-BIOMED, Diepenbeek, Belgium; 2Dept. Medical Biochemistry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 3Dept. Physiology, Loyola University Chicago, Maywood, IL, United States; 4Dept. Medical Chemistry,

359 WEDNESDAY, JUNE 12 POSTERS

W031 THIAZIDE-INDUCED HYPOCALCIURIA AS A CONSEQUENCE OF A COMPENSATORY RESPONSE TO HYPOVOLEMIA Tom Nijenhuis,1 Joost G.J. Hoenderop,1 Johannes Loffing,2 Annemiete W.C.M. van der Kemp,1 Carel H. van Os,1 Rene J.M. Bindels.1 1Department of Cell Physiology, University Medical Center Nijmegen, Netherlands; 2Institute of Anatomy, University of Zurich, Switzerland

W032 ROLE OF DIFFERENTIAL MRG1AND TRPM6 GENE EXPRESSION IN CONTROL OF RENAL MAGNESIUM HANDLING Gary A. Quamme,1 Martin Konrad.2 1Medicine, University of British Columbia, Vancouver, BC, Canada; 2Pediatrics, University Children’s Hospital, Marburg, Germany

W033 REGULATION OF THE EPITHELIAL CA2+ CHANNEL TRPV5 BY THE NHE REGULATING FACTOR NHERF2 AND THE SERUM AND GLUCOCORTICOID INDUCIBLE KINASE ISOFORMS SGK1- 3 AND PROTEIN KINASE B Christoph Boehmer,1 Hamdy M. Embark,1 Iwan Setiawan,1 Stan van de Graaf,2 Monica Palmada,1 Thomas Wieder,1 Chris Yun,3 Rene J. Bindels,2 Florian Lang.2 1Dept. of Physiology, University of Tuebingen, Tuebingen, Germany; 2Dept. of Physiology, University of Nijmegen, Nijmegen, Netherlands; 3Dept. of Medicine, Emory University, Atlanta, GA, United States

W034 FUNCTIONAL EXPRESSION OF THE EPITHELIAL CA2+ CHANNELS (TRPV5 AND TRPV6) REQUIRES ASSOCIATION OF THE S100A10-ANNEXIN 2 COMPLEX Stan F.J. van de Graaf,1 Joost G.J. Hoenderop,1 Dimitra Gkika,1 Dennis Lamers,1 Jean Prenen,2 Ursula Rescher,3 Volker Gerke,3 Olivier Staub,4 Bernd Nilius,2 Rene J.M. Bindels.1 1Department of Cell Physiology, University Medical Center Nijmegen, Nijmegen, Netherlands; 2Department of Physiology, Campus Gasthuisberg, KU Leuven, Leuven, Belgium; 3Institute of Medical Biochemistry, University of Muenster, Muenster, Germany; 4Institute of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland

360 POSTERS WEDNESDAY, JUNE 12

PROTEIN SORTING / EPITHELIAL POLARITY WEDNESDAY

W035 VISUALIZATION OF TUBULAR SHORT-CHAIN PEPTIDE UPTAKE Roland Schmitt,1 Frank Döring,2 David A. Groneberg.3 1Inst. of Anatomy, Charite School of Medicine, Berlin, Germany; 2Inst.of Nutritional Sciences, Technical Univ. of Munich, Freising, Germany; 3Dept of Medicine, Research Center Borstel/ Univ.of Luebeck, Borstel, Germany

W036 POLARIZED DISTRIBUTION OF HYALURONAN AND CD44 DURING RENAL TUBULAR EPITHELIAL DEVELOPMENT AND WOUND HEALING M. Asselman,1 A. Verhulst,2 M.E. De Broe,2 C.F. Verkoelen.1 1Dept. of Urology, Erasmus MC Rotterdam, Netherlands; 2Dept. of Nephrology-Hypertension, Univ. of Antwerp, Belgium

W037 DIFFERENTIAL ACTIONS OF PAR2 AND PAR1 IN STIMULATING HUMAN ENDOTHELIAL CELL EXOCYTOSIS AND PERMEABILITY: THE ROLE OF RHO GTPases Allan Murray,1 Scott Klarenbach,1 Adam Chipiuk,1 Randy Nelson,1 Morley Hollenberg.2 1Dept of Medicine, Univ. of Alberta, Edmonton, AB, Canada; 2Depts of Medicine, and Pharmacology and Therapeutics, Univ.of Calgary, Calgary, AB, Canada

W038 MEMBRANE ORGANIZATION OF ESSENTIAL PROTEINS OF THE THICK ASCENDING LIMB RELATED TO ION TRANSPORT J.H. Fruehauf,1 P. Welker,1 K. Mutig,1 T.J. Jentsch,2 E. Kinne-Safran,3 S. Kumar,4 S. Bachmann.1 1Dept of Anatomy, Med. Faculty of the Humboldt-Univ., Berlin, Germany; 2Zentrum fuer Molekulare Neurobiologie, Hamburg, Germany; 3Max Planck Inst. for Molecular Physiology, Dortmund, Germany; 4Dept of Nephrology, Univ.of Oklahoma, Oklahoma City, USA

W039 TGF-BETA1 REDUCES MEGALIN/CUBILIN-MEDIATED ENDOCYTOSIS OF ALBUMIN IN PROXIMAL TUBULE DERIVED OK-CELLS Michael Gekle,1 Petra Knaus,2 Rikke Nielsen,3 Sigrid Mildenberger,1 Ruth Freudinger,1 Verena Wohlfarth,1 Christoph Sauvant,1 Erik I. Christensen.3 1Dept of Physiology, Univ. of Würzburg, Würzburg, Germany; 2Biocenter, Physiologische Chemie, Univ. of Würzburg, Würzburg, Germany; 3Dept of Cell Biology, Inst. of Anatomy, Univ. of Aarhus, Aarhus, Denmark

W040 RHO/RHO-KINASE PATHWAY REGULATES MAINTENANCE OF DIFFERENTIATED TUBULAR EPITHELIAL CELL PHENOTYPE ON LAMININ-1 Irith Reuters, Lutz Buschhausen, Oya Goektas, Manfred Weber, Eckhard Schulze-Lohoff. Dept. of Medicine I, Merheim Medical Center, Cologne General Hospital, Medical Faculty of Cologne Univ., Cologne, NRW, Germany

W041 PSEUDOMONAS AERUGINOSA AFFECTS ENDOCYTIC TRAFFICKING OF CFTR Agnieszka Swiatecka-Urban,1 John P. Connolly,2 Roxanna Barnaby,1 George O’Toole,2 Bruce A. Stanton.1 1Physiology, Dartmouth Medical School, Hanover, NH, USA; 2Microbiology and Immunology, Dartmouth Medical School, Hanover, NH, USA

W042 VISUALISATION OF THE RENAL TUBULE HANDLING OF INSULIN BY COMBINING CONFOCAL MICROSCOPY WITH IN VIVO RENAL MICROPUNCTURE Angelo Pica,1,3 Adelina Simeoni,1,3 Alan Boyde,2 David G. Shirley,1 Giovambattista Capasso,3 Robert J. Unwin.1 1Centre for Nephrology, Univ.College London, London, UK; 2Dept of Anatomy and Developmental Biology, Univ. College of London, London, UK; 3Chair of Nephrology, Second Univ.of Naples, Naples, Italy

361 WEDNESDAY, JUNE 12 POSTERS

EXTRACELLULAR MEDIATORS (CYTOKINES, PROSTANOIDS, NUCLEOTIDES, RADICALS)

W043 TGF-β STIMULATES THE MKK3/MKK6/p38/ATF-2 CASCADE IN RENAL EPITHELIAL LLC-PK1-FBPase+ CELLS Manfred Andratsch, Elisabeth Feifel, Herbert Schramek, Gerhard Gstraunthaler. Department of Physiology, University of Innsbruck, Innsbruck, Austria

W044 TGF-β INDUCES PEPCK AND GLUTAMINASE mRNA LEVELS IN RENAL EPITHELIAL LLC-PK1-FBPase+ CELLS Elisabeth Feifel, Manfred Andratsch, Gerhard Gstraunthaler. Department of Physiology, University of Innsbruck, Innsbruck, Austria

W045 MECHANISM OF TGF-β-INDUCED FIBRONECTIN SYNTHESIS BY HIGH GLUCOSE IN NRK FIBROBLASTS: THE ROLE OF THE MAPK CASCADE AND THE Smad PATHWAY Hitoe Suzuki,1 Keiko Uchida,2 Kosaku Nitta,2 Takashi Akiba,3 Hiroshi Nihei.2 1Nephrology, Tokyo Metropolitan Komagome Hospital, Bunkyo-ku, Tokyo, Japan; 2Medicine IV, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan; 3Blood Purification, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

W046 2-METHOXY-ESTRADIOL UPREGULATES MAP-KINASE PHOSPHATASE-1 EXPRESSION AND BLOCKS ACTIVATION OF P38-MAP KINASE AND INDUCTION OF PAI-1 BY TRANSFORMING GROWTH FACTOR BETA IN RENAL FIBROBLASTS Jens Gaedeke,1 Nancy A. Noble,2 Wayne A. Border.2 1Medizinische Klinik m.S. Nephrologie, CharitéCampus Mitte, Berlin, Germany; 2Fibrosis Research Laboratory, University of Utah, Salt Lake City, UT, United States

W047 OVERLAPPING SIGNALING PATHWAYS OF S1P1 AND S1P3 AND TGFβ RECEPTORS IN MURINE DENDRITIC CELLS Heinfried H. Radeke,1 Hendrik von Wenckstern,2 Kirsten Stoidtner,1 Christin Schraut,2 Burkhard Kleuser.2 1Pharmazentrum Frankfurt, Clinic of the J.-W. Goethe University, Frankfurt am Main, Germany; 2Institute of Pharmacy, Free University of Berlin, Berlin, Germany

W048 POSITIVE AND NEGATIVE REGULATORS OF TGF-β1/BMP PATHWAYS ARE CONSTITUTIVELY EXPRESSED IN MESANGIAL CELLS Thiago Trovati Maciel, Clarissa Fantin Cavarsan, Alexandre Holthausen Campos, Nestor Schor. Medicine/Nephrology, Unifesp, Sao Paulo, SP, Brazil

W049 FUNCTIONAL COOPERATION BETWEEN SMAD PROTEINS AND AP-1 REGULATES TRANSFORMING GROWTH FACTOR-beta - MEDIATED INDUCTION OF ENDOTHELIN-1 EXPRESSION Fernando Rodriguez-Pascual,1,2,3 Mariano Redondo-Horcajo,1,2,3 Santiago Lamas.1,2,3 1Estructura y Funcion de Proteinas, Centro de Investigaciones Biologicas-CSIC, Madrid, Spain; 2Instituto “Reina Sofia” de Investigaciones Nefrologicas, Madrid, Spain; 3Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

362 POSTERS WEDNESDAY, JUNE 12

W050 STAT-1 INDEPENDENT TGF-β1 INHIBITON OF CLASS II TRANSACTIVATOR AND CLASS II MHC EXPRESSION IN HUMAN GLOMERULAR ENDOTHELIAL CELLS Su-Kil Park,1 Won Seok Yang,1 Nam Jung Han,1 Sang Koo Lee,1 Jang WEDNESDAY Won Seo,1 Hanjong Ahn,2 Ki-Up Lee,1 Jae Dam Lee.3 1Internal Medicine, College of Medicine, Univ. of Ulsan, Seoul, Republic of Korea; 2Urology, College of Medicine, Univ. of Ulsan, Seoul, Republic of Korea; 3Biochemistry, College of Medicine, Univ. of Ulsan, Seoul, Republic of Korea

W051 TGF-β1 STIMULATES GLOMERULAR ENDOTHELIAL CELL (GEN) APOPTOSIS THROUGH A CATHEPSIN-DEPENDENT MECHANISM Raluca Coyle, Barbara J. Ballermann. Nephrology, Albert Einstein College of Medicine, Bronx, NY, United States

W052 INVOLVEMENT OF PKC, NOT MAPK IN TGF-beta STIMULATED CTGF mRNA EXPRESSION IN HUMAN PROXIMAL TUBULAR CELL Bi-Cheng Liu,1 Yu-Jie Wen,1 Xiao-Liang Zhang,1 Kun-Ling Ma,1 Aled O. Phillips.2 1Institute of Nephrology, Zhong Da Hospital, Southeast University, Nanjing, Jiang Su Province, China; 2Institute of Nephrology, University of Wales College of Medicine, Cardiff, United Kingdom

W053 TGF-β AUTOINDUCTION IN HUMAN RENAL EPITHELIAL CELLS REQUIRES N-RAS AND ERK-1/2 MAP KINASES Mark Dockrell,1 Brett Monia,2 Bruce Hendry.1 1Renal Medicine, King’s College London, London, England, United Kingdom; 2Molecular Pharmacology, ISIS Pharmaceuticals, Carlsbad, CA, United States

W054 ROXITHROMYCIN INHIBITS TGF-BETA PRODUCTION IN CULTURED HUMAN MESANGIAL CELLS Hideaki Yamabe, Hiroshi Osawa, Norio Nakamura, Mitsuaki Kaizuka, Ken-ichi Shirato, Toshiyuki Sugawara, Masayuki Nakamura, Michiko Tamura, Ken Okumura. Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan

W055 IMPAIRED NO SIGNAL TRANSDUCTION IS LINKED TO TGF-β OVEREXPRESSION IN ANTI-THY1 GLOMERULONEPHRITIS Harm Peters, Ying Rui Wang, Sebastian Martini, Matthias Rückert, Ute Daig, Stephanie Krämer, Hans-H. Neumayer. Nephrology, CharitéCampus Mitte, Humboldt-University, Berlin, Germany

W056 MECHANISMS OF BMP7’s ANTAGONISM TO TGFb Shinong Wang, Janine LaPage, Raimund Hirschberg. Division of Nephrology, Research & Education Institute at Harbor- UCLA Medical Center, Torrance, CA, United States

W057 FTY 720 LIMITS TGF-β OVEREXPRESSION AND MATRIX EXPANSION IN ACUTE ANTI-THY1 GLOMERULONEPHRITIS Harm Peters, Sebastian Martini, Matthias Rückert, Ying Rui Wang, Stephanie Krämer, Sebastian Bachmann. Nephrology, CharitéHumboldt-University, Berlin, Germany

W058 ROLE OF TRANSFORMING GROWTH FACTOR INDUCED BY PODOCYTE IN THE PATHOGENESIS OF DIABETIC NEPHROPATHY Hyoungkyu Kim, Youngsun Kang, DaeRyung Cha. Division of Nephrology, Korea University Hospital, Seoul, Korea

363 WEDNESDAY, JUNE 12 POSTERS

W059 TYPE 1 PLASMINOGEN ACTIVATOR INHIBITOR DEFICIENCY AGGRAVATES THE COURSE OF EXPERIMENTAL PASSIVE GLOMERULONEPHRITIS THROUGH TGF-BETA OVERACTIVATION Alexandre Hertig,1 Jeannig Berrou,2 Yves Allory,1 Frederic Commo,3 Laetitia Breton,1 Marie-Alyette Costa de Beauregard,1 Peter Carmeliet,4 Eric Rondeau.1 1Inst National Sante et Recherche Medicale, U489, Paris, France; 2Assoc Claude Bernard, Paris, France; 3Dept Pathology, Hop Tenon, Paris, France; 4Center Transgene Technology and Gene Therapy, Flanders Interuniversity Inst Biotechnology, Leuven, Belgium

W060 IDENTIFICATION OF PDGF-D AS A NOVEL MEDIATOR OF MESANGIOPROLIFERATIVE GLOMERULONEPHRITIS Tammo Ostendorf,1 Claudia R.C. van Roeyen,1 Jeffrey D. Peterson,2 Uta Kunter,1 Frank Eitner,1 Avin J. Hamad,1 Gerlinde Chan,3 Xiao- Chi Jia,3 Jennifer Macaluso,2 Gadi Gazit-Bornstein,3 Bruce A. Keyt,3 Henri S. Lichenstein,2 William J. LaRochelle,2 Jürgen Floege. 1Nephrology, University of Aachen, Aachen, Germany; 2CuraGen Corporation, Branford, CT, United States; 3Abgenix Inc., Fremont, CA, United States

W061 RESEARCH OF THE EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND ITS RECEPTOR IN RENAL TISSUE OF IgA NEPHROPATHY Suo-Zhu Shi, Xiang-Mei Chen, Xue-Guang Zhang. Department of Nephrology, General Hospital of PLA, Beijing, China

W062 VASCULAR ENDOTHELIAL GROWTH FACTOR IN DIFFERENT RENAL DISEASES WITH PROTEINURIA Hesham Safouh,1 Ghada Anwar,2 Hoda Abdel Ghani,3 Ahmed Zaghloul.1 1Department of Pediatrics, Pediatric Nephrology Unit, Cairo University, Egypt; 2Department of Pediatrics, Diabetes Endocrine Metabolic Unit, Cairo University, Egypt; 3Department of Clinical Pathology, Cairo University, Egypt

W063 INCREASED SYNTHESIS OF VEGF-A AND IL-6 IN ISCHAEMIA/ REPERFUSION INDUCED ACUTE RENAL FAILURE IN RATS Adam Vannay,1 Andrea Fekete,1 Csaba Adori,2 Tibor Toth,3 Gyorgy Losonczy,4 Lajos Laszlo,2 Barna Vasarhelyi,1 Tivadar Tulassay,1 Andras Szabo.1 11Research Laboratory of Pediatrics and Nephrology, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary; 22Department of General Zoology, Eotvos University of Sciences, Budapest, Hungary; 3Department of Pathology, Semmelweis University, Budapest, Hungary; 4Department of Pulmonology, Semmelweis University, Budapest, Hungary

W064 VEGF INDUCTON IN PROXIMAL TUBULAR CELLS OCCURS VIA SEPARATE HYPOXIA- AND TGF-BETA DRIVEN PATHWAYS Takahiko Nakagawa, Jin H. Li, Richard J. Johnson, Hui Y. Lan. Division of Nephrology-Medicine, Baylor College of Medicine, Houston, TX, United States

W065 SYSTEMIC OVEREXPRESSION OF VEGF165 AGGRAVATES MESANGIOPROLIFERATIVE NEPHRITIS IN RATS Uta Kunter,1,2 Song Rong,1 Claudia van Roeyen,1 Maja Milovanceva-Popovska,1 Tammo Ostendorf,1 Willi Jahnen- Dechent,2 Hermann-Josef Groene,3 Enyu Imai,4 Juergen Floege.1 1Nephrology, University of Aachen, Aachen, Germany; 2IZKF BIOMAT, University of Aachen, Aachen, Germany; 3Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany; 4Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan

364 POSTERS WEDNESDAY, JUNE 12

W066 PROSTAGLANDIN D SYNTHASE GENE TRANSFER INHIBITS RELEASE OF VASCULAR CELL ADHESION MOLECULE-1 GENERATION FROM BOVINE ENDOTHELIAL CELLS Hideyuki Negoro, Yoshio Uehara, Atsuo Goto, Wee Soo Shin, Masao WEDNESDAY Omata, Toshiro Fujita. Internal Medicine, University of Tokyo, Tokyo, Japan

W067 INSULIN-LIKE GROWTH FACTOR 1 ABOLISHES ACID-INDUCED PROTEIN DEGRADATION IN CULTURED SKELETAL MUSCLE CELLS Alan Bevington, Sheena Govindji, Jeremy Brown. Dept of Nephrology, Leicester General Hospital, Leicester, UK

W068 EFFECT OF HIGH GLUCOSE, ANGIOTENSIN II AND RECEPTOR ANTAGONIST LOSARTAN ON THE EXPRESSION OF CONNECTIVE TISSUE GROWTH FACTOR IN CULTURED MESANGIAL CELLS Songmin Huang, Fang Lu, Ping Fu, Li Zhou. Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China

W069 EFFECTS OF SPECIFIC CYCLOOXYGENASE-2 INHIBITOR ON PROTEINURIA AND PROGRESSIVE RENAL INJURY IN RATS WITH ADRIAMYCIN NEPHROSIS Weixin Kong,1 Shanyan Lin,2 Yong Gu.2 1Division of Nephrology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China; 2Division of Nephrology, Fudan University Huanshan Hospital, Shanghai, China

W070 EFFECTS OF ADVANCED OXIDATION PROTEIN PRODUCTS MODIFIED PROTEIN IN HUMAN ENDOTHELIAL CELL LINE Hong Fan, Yong Gu, Feng Ding, Qiuyue Zhu, Shanyan Lin. Division of Nephrology, Huashan Hospital, Shanghai, China

W071 INHIBITION OF ECM SECRETION IN RAT MESANGIAL CELLS CULTURED WITH HIGH GLUCOSE BY SMAD2 ANTISENSE PLASMID Shengqiang Yu, Lingyun Lai, Yong Gu, Ji Ma, Shanyan Lin. Division of Nephrology, Huashan Hospital, Shanghai, China

W072 THE EFFECT OF IRBESARTAN ON ANGIOTENSIN II INDUCED HYPERTROPHY OF HUMAN PROXIMAL TUBULAR CELLS Bi-Cheng Liu,1 Jing Sun,1 Kun-Ling Ma,1 Xiao-Liang Zhang,1 John D. Williams.2 1Institute of Nephrology, Zhong Da Hospital, Southeast University, Nanjing, Jiang Su Province, China; 2Institute of Nephrology, University of Wales College of Medicine, Cardiff, United Kingdom

W073 THE INTERACTION OF FIBROGENIC AND INFLAMMATORY FACTORS IN NEPHROTOXIC NEPHRITIS (NTN) UNDER IMMUNOSUPPRESSIVE TREATMENT Ekaterina Paltseva, Olga Gladskikh, Alexei Ivanov. Cellular and Molecular Pathology, Research Institute of Molecular Medecine at Moscow Medical Academy, Moscow, Russian Federation

W074 INTACT POLYUNSATURATED FATTY ACID AND VITAMIN E CONCENTRATIONS IN OXIDATIVELY MODIFIED LOW DENSITY LIPOPROTEIN (LDL) Zsuzsa Varga,1 Gyorgy Balla,2 Viktoria Jeney,1 Laszlo Ujhelyi,1 Gyorgy Kakuk,1 Gregory M. Vercellotti,3 Akihiro Yachie,4 Jozsef Balla.1 1First Dept of Medicine, Medical and Health Science Center Univ of Debrecen; 2Dept of Neonatology, Medical and Health Science Center Univ of Debrecen, Debrecen, Hungary; 3Dept of Medicine, Univ. of Minnesota, Minneapolis, USA; 4Dept of Lab.Sciences, Kanazawa Univ., Japan

365 WEDNESDAY, JUNE 12 POSTERS

W075 ADENOSINE 4’-TETRAPHOSPHATE IS A POTENT MODULATOR OF VASCULAR TONE IN THE KIDNEY Günter Giebing, Sven Schmidt, Markus Tölle, Joachim Jankowski, Walter Zidek, Markus van der Giet. Freie Universität Berlin, UKBF, Medizinische Klinik IV, Berlin, Germany

W076 REGULATION OF MONOCYTE RECEPTOR COMPLEXES BY IL- 10 IN VITRO - A POTENTIALLY IMPORTANT MECHANISM FOR INFLAMMATION AND ATHEROSCLEROSIS Christof Ulrich, Martina Sester, Urban Sester, Hans Köhler, Matthias Girndt. Dept of Nephrology, Univ. of Homburg/Saar, Homburg, Germany

W077 IL-10 INDUCED UP-REGULATION OF ACE (ANGIOTENSIN CONVERTING ENZYME) EXPRESSION IN DIFFERENT MONOCYTE SUBPOPULATIONS Christof Ulrich, Anke Mütherig, Urban Sester, Martina Sester, Gunnar Heine, Hans Köhler, Matthias Girndt. Dep. of Nephrology, University of Homburg/Saar, Homburg, Germany

W078 THE EFFECTS OF SELENIUM AND TRIMETAZIDINE ON RENAL TISSUE LIPID PEROXIDATION AND SUPEROXIDE DISMUTASE LEVELS AFTER ACUTE RENAL ISCHAEMIA AND REPERFUSION IN RATS Ibrahim Karayaylali,1 Mustafa Emre,2 Neslihan Seyrek,1 Sule Menziletoglu Yildiz,3 Seyda Erdogan,4 Mustafa Balal,1 Saime Paydas,1 Ilhan Tuncer,4 Nazan Alparslan.5 1Nephrology, Cukurova University, Adana, Turkey; 2Biophysics, Cukurova University, Adana, Turkey; 3Biochemistry, Cukurova University, Adana, Turkey; 4Pathology, Cukurova University, Adana, Turkey; 5Biostatistics, Cukurova University, Adana, Turkey

W079 GENE REGULATION AND EXPRESSION OF ADENOSINE RECEPTOR mRNA IN THE RAT NEPHRON Helga Vitzthum, Armin Kurtz. Institut fuer Physiologie, Univ. Regensburg, Regensburg, Germany

W080 VISCERAL PERIVASCULAR ADIPOSE TISSUE REGULATES ARTERIAL TONE OF SMALL MESENTERIC ARTERIES Stefan Verlohren,1 Galyna Dubrovska,1 Suk-Yin Tsang,2 Friedrich C. Luft,1 Yu Huang,2 Maik Gollasch.1 1HELIOS Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty Charité Humboldt University Berlin, Berlin, Germany; 2Department of Physiology, Chinese University of Hong Kong, Hong Kong, China

W081 DIRECT TISSUE NO AND BLOOD FLOW MEASUREMENTS IN RENAL CORTEX AND MEDULLA OF ANAESTHETISED RATS: EFFECTS OF NO SYNTHASE INHIBITORS Monika Grzelec-Mojzesowicz, Janusz Sadowski. Laboratory of Renal & Body Fluid Physiology, M. Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

W082 MACULA DENSA CONTROL OF RENIN SECRETION IN NEURONAL NITRIC OXIDE SYNTHASE DEFICIENT MICE Hayo Castrop, Yuning Huang, Josephine P. Briggs, Jurgen Schnermann. NIDDK, National Institutes of Health, Bethesda, MD, United States

W083 THE EFFECTS OF iNOS INDUCTION ON THE PHOSPHORYLATION OF VASP IN HUMAN PROXIMAL TUBULAR EPITHELIAL CELLS Susan Crail, Thomas Evans. Dept of Infectious Diseases, Imperial College, London, UK

366 POSTERS WEDNESDAY, JUNE 12

W084 HUMAN PROXIMAL TUBULAR CELLS (HK-2) IN CULTURE PRODUCE NITRIC OXIDE AND EXPRESS iNOS UNDER BASAL CONDITIONS María Natalia Márquez,1,2 Adriana Tiscornia,5 Ernesto Cairoli,2,3 WEDNESDAY Cecilia Brito,5 Ana Denicola,6 Alfonso Cayota,3 Oscar Noboa.1,4 1Departamento de Fisiopatología, Facultad de Medicina, Montevideo, Uruguay; 2Clínica Médica C, Facultad de Medicina, Montevideo, Uruguay; 3Departamento Básico de Medicina, Facultad de Medicina, Montevideo, Uruguay; 4Centro de Nefrología, Facultad de Medicina, Montevideo, Uruguay; 5Departamento de Bioquímica, Facultad de Medicina, Montevideo, Uruguay; 6Laboratorio de Fisicoquimica Biológica, Facultad de Ciencias; Universidad de la República, Montevideo, Uruguay

W085 ROLE OF A1 ADENOSINE RECEPTORS AND NO IN MACULA DENSA CONTROL OF RENIN SECRETION: STUDIES IN ISOLATED PERFUSED KIDNEYS OF KNOCKOUT MICE Frank Schweda, Armin Kurtz. Institute for Physiology, University of Regensburg, Regensburg, Germany

W086 ACUTE AND CHRONIC REGULATION OF THICK ASCENDING LIMB eNOS BY STATINS Marisela Varela,1 Jeffrey L. Garvin.1 1Nephrology and Hypertension, Henry Ford Health System, Detroit, MI, United States; 2Hypertension and Vascular Research, Henry Ford Health System, Detroit, MI, United States

367 WEDNESDAY, JUNE 12 POSTERS

EXTRACELLULAR MATRIX, FIBROSIS

W087 CLONING AND FUNCTIONAL ANALYSIS OF ANGREM104, A NOVEL GENE RELATED TO THE SCLEROSIS OF HUMAN MESANGIAL CELLS Xiubin Liang, Hong Zhang, Anyu Zhou, Haiyan Wang. Renal Division, First Hospital of Peking University, Beijing, China

W088 MORPHOLOGICAL AND FUNCTIONAL CHARACTERIZATION OF HABU SNAKE VENOM NEPHROPATHY IN MICE Christian Stefan Haas,1 Christian Forster,2 Harald Schoecklmann,3 Andrea Hartner,4 Udo Reulbach,5 Kerstin Amann.2 1Department of Pathology, Northwestern University, Chicago, IL, United States; 2Department of Pathology, Friedrich-Alexander- University, Erlangen, Germany; 3Department of Nephrology, University of Kiel, Kiel, Germany; 4Department of Nephrology, Friedrich-Alexander-University, Erlangen, Germany; 5Department of Medical Informatics, Biometry and Epidemiology, Friedrich- Alexander-University, Erlangen, Germany

W089 RENAL WARM ISCHAEMIA AND CYCLOSPORINE EXERT A SYNERGISTIC EFFECT ON INJURY AND FIBROSIS IN THE KIDNEY Ahmed Ahmed, Aymen Ahmed, Maguid EL Nahas, Andrew Raftery, John Haylor. Renal Transplant Unit, Sheffield Kidney Institute, Northern General Hospital, Sheffield, United Kingdom

W090 ELEVATION OF INTRACELLULAR CYCLIC NUCLEOTIDE CONCENTRATIONS INHIBITS IN VITRO MITOGENESIS AND ACTIVATION OF FIBROBLASTS DERIVED FROM OBSTRUCTED RAT KIDNEYS Tim Hewitson,1 Marina Martic,1 Kristen Kelynack,1 Ian Darby,2 Melanie Tait,1 Gavin Becker.1 1Nephrology, The Royal Melbourne Hospital, Melbourne, VIC, Australia; 2Human Biology, RMIT, Melbourne, VIC, Australia

W091 VERY YOUNG KIDNEY IS MORE RESISTANT TO GLOMERULOSCLEROSIS Hyewon Hahn,2 Bum Hee Lee,1 Hee Gyung Kang,1 Hae Il Cheong,1 Yong Choi,1 Il Soo Ha.1 1Pediatrics, Seoul National University Children’s Hospital, Seoul, Korea; 2Pediatrics, Ulsan Medical School, Asan Medical Center, Seoul, Korea

W092 EXTRACELLULAR MATRIX ACCUMULATION IS INDUCED BY INTRAMESANGIAL COAGULATION THROUGH FACTOR V EXPRESSION IN MESANGIOPROLIFERATIVE GLOMERULONEPHRITIS IN RATS Ning Liu,1 Takahiko Ono,1 Fumiaki Nogaki,1 Eri Muso,2 Gisho Honda,3 Toru Kita.1 1Div of Nephrology, Dept of Cardiovascular Medicine, Graduate School of Medicine, Kyoto Univ, Kyoto, Japan; 2Div of Nephrology, Kitano Hospital, Osaka, Japan; 3Dept of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto Univ, Kyoto, Japan

W093 ROLE OF FIBRILLIN-1 IN THE REGULATION OF MESANGIAL CELL ATTACHMENT AND PROLIFERATION Andrea Hartner,1 Beate Bieritz,1 Ewa Konik,1 Dieter Reinhardt.2 1Medizinische Klinik IV, Universität Erlangen-Nürnberg, Erlangen, Germany; 2Institut für Medizinische Molekularbiologie, Universität zu Lübeck, Lübeck, Germany

368 POSTERS WEDNESDAY, JUNE 12

W094 INDIVIDUAL SUSCEPTIBILITY TO HIGH GLUCOSE AND HYPOXIA INDUCED RENAL FIBROSIS Weier Qi,1 Philip Poronnik,1 Chris Jackson,2 Michael Field,3 Carol Pollock.1 WEDNESDAY 1Medicine, Kolling Inst., Sydney, NSW, Australia; 2Sutton Laboratories, Royal North Shore Hosp., Sydney, NSW, Australia; 3Northern Clinical School, Univ. of Sydney, Sydney, NSW, Australia

W095 ALDOSTERONE COINDUCES EXTRA CELLULAR MATRIX PRODUCTION AND AT1 EXPRESSION IN RAT GLOMERULAR MESANGIAL CELLS Lingyun Lai, Yong Gu, Jing Chen, Shengqiang Yu, Haichun Yang, Shanyan Lin. Division of Nephrology, Huashan Hosptial, Shanghai, China

W096 THE BENEFICIAL EFFECT OF MELATONIN ON CHRONIC CYCLOSPORIN NEPHROTOXICITY IN RATS Mukaddes Esrefoglu,1 Meltem Kurus,1 Engin Sahna.2 1Histology and Embryology, Inönü University Medical Faculty, Malatya, Turkey; 2Pharmacology, Inönü University Medical Faculty, Malatya, Turkey

W097 REGRESSION OF GLOMERULOSCLEROSIS BY INHIBITION OF ALDOSTERONE IS LINKED TO PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) Li-Jun Ma, Jean Claude Aldigier, Talerngsak Kanjanabuch, Nancy J. Brown, Agnes B. Fogo. Pathology, Vanderbilt University Medical Center, Nashville, TN, United States

W098 EFFECTS OF THE EXTRACELLULAR MATRIX ON INTRACELLULAR CALCIUM SIGNALING AND PROTEIN EXPRESSION IN IMMORTALIZED MOUSE MESANGIAL CELL Vicente de Paulo Castro Teixeira, Maria Adelaide Cunha, Nestor Schor. Med.-Nephrology Div., Univ. Federal de Sao Paulo, Sao Paulo, Brazil

W099 THE ROLE OF p38 MAPK SIGNALLING IN RENAL FIBROSIS Cosimo Stambe,1 Haidong Yan,1 Robert Atkins,1 Greg Tesch,1 Takao Masaki,1 Rita Foti,1 Ann Kapoun,2 George Schreiner,2 David Nikolic-Paterson.1 1Dept of Nephrology and Monash University Dept of Medicine, Monash Medical Centre, Melbourne, Victoria, Australia; 2Scios Inc, San Francisco, CA, United States

W100 LESS MACROPHAGE INFILTRATION AND FIBROSIS IN RKs OF OSTEOPONTIN Veerle P. Persy, Anja Verhulst, Sven R. Vercauteren, Marc E. De Broe. Dept of Nephrology, University of Antwerp, Belgium

W101 CD44 IS IMPLICATED IN THE DESTRUCTION OF THE CAPILLARY NETWORK AND MACROPHAGES INFLUX IN OBSTRUCTIVE NEPHROPATHY Kasper Rouschop, Nike Claessen, Inge Hoedemaeker, Jan Weening, Sandrine Florquin. Pathology, Academic Medical Center, Amsterdam, Netherlands

W102 ROLE OF ENDOTHELIN-1 (ET-1)/ENDOTHELIN B (ETB) RECEPTOR IN THE DEVELOPMENT OF TUBULOINTERSTITIAL FIBROSIS IN CHRONIC HYPOKALEMIA Christoph Licht,1,3 Joseph X. Zhou,1 Weiguo Zhang,1 Masashi Yanagisawa,2 Robert J. Alpern,1 Patricia A. Preisig.1 1Nephrology, UTSW Medical Center, Dallas, TX, United States; 2Howard Hughes Medical Institute, UTSW Medical Center, Dallas, TX, United States; 3Pediatric Nephrology, Children’s Hospital of the University of Cologne, Cologne, Germany

369 WEDNESDAY, JUNE 12 POSTERS

W103 SEVERE GLOMERULOSCLEROSIS IN MALE BUT NOT IN FEMALE RATS OVEREXPRESSING ENDOTHELIN Lutz Liefeldt,1,2 Johannes Manhart,1 Bartosz Rylski,1 Martin Paul,2 Harm Peters,1 Hans-H. Neumayer.1 1Nephrology, CharitéBerlin, Germany; 2Clinical Pharmacology and Toxicology, Free University, Berlin, Germany

W104 RENAL VASCULAR AND GLOMERULAR FIBROSIS: ROLE OF EPIDERMAL GROWTH FACTOR RECEPTOR TRANSACTIVATION Hélène François, Sandrine Placier, Jean-Claude Dussaule, Christos Chatziantoniou. Inserm U489, Hôpital Tenon, Paris, France

W105 MODULAR CIS-ACTING ELEMENTS REQUIRED FOR THE ALPHA 2 TYPE IV COLLAGEN PROMOTER IN TISSUE-SPECIFIC TRANSCRIPTION Noriyuki Iehara, Hajime Imai, Hiroko Ida, Yoshihiko Yamada. NIDCR, NIH, Bethesda, MD, United States

W106 A SEMI-QUANTITATIVE ANALYSIS OF anb6 INTEGRIN EXPRESSION IN 273 BIOPSIES OF NATIVE AND TRANSPLANTED KIDNEYS Paul Trevillian,1 Helen Paul,2 Ewan Millar,3 Adrian Hibberd,1 Michael Agrez.1 1Division of Surgery, 2Department of Anatomical Pathlology, John Hunter Hospital, Newcastle, NSW, Australia; 3Department of Anatomical Pathlology, SEALS, St.George Hospital, Kogarah, Sydney, NSW, Australia

W107 ALPHA 2 BETA 1 INTEGRIN INDUCES ICAM-1 EXPRESSION IN HUMAN MESANGIAL CELLS Masahito Tamura,1 Akihiko Osajima,1 Shingo Nakayamada,2 Hirofumi Anai,3 Narutoshi Kabashima,3 Ryota Serino,3 Yoshiya Tanaka,2 Yasuhide Nakashima.3 1Kidney Center, University Occupational & Environmental Health, Kitakyushu, Fukuoka, Japan; 2First Department of Internal Medicine, University Occupational & Environmental Health, Kitakyushu, Fukuoka, Japan; 3Second Department of Internal Medicine, University Occupational & Environmental Health, Kitakyushu, Fukuoka, Japan

W108 ACTIVATION OF INTEGRIN-LINKED KINASE (ILK) IN MESANGIOPROLIFERATIVE GLOMERULONEPHRITIS IN RATS Shoji Kagami,1 Maki Urushihara,1 Shuji Kondo,1 Akiko Kitamura,1 Maki Shimizu,1 Toshiaki Tamaki,2 Hiroshi Kawachi,3 Fujio Shimizu,3 Yasuhiro Kuroda.1 1Dept. of Pediatr., Tokushima Univ. Sch. of Med, Tokushima, Japan; 2Dept. of Pharmacol., Tokushima Univ. Sch. of Med, Tokushima, Japan; 3Dept. of Cell Biol, Inst. Nephrol, Niigata Univ. Sch. of Med, Niigata, Japan

W109 THE ADAMS FAMILY AND DIABETIC NEPHROPATHY: EXPRESSION OF A NOVEL FAMILY OF EXTRACELLULAR MATRIX MODULATING GENES IN HUMAN MESANGIAL CELLS Stephen Jones, Jez Mohammed, Norman McKie. School of Clinical Medical Sciences, University of Newcastle Upon Tyne, Newcastle upon Tyne, United Kingdom

W110 EXPRESSION OF MATRIX METALLOPROTEINASE-9 ASSOCIATED WITH ets-1 PROTO-ONCOGENE IN RAT TUBULOINTERSTITIAL CELLS Takashi Naito,1 Yoko Tanihata,1 Hideki Nishimura,1 Chieko Higuchi,1 Takashi Taguchi,2 Tsutomu Sanaka.1 1Medicine, Tokyo Women’s Medical University Daini Hospital, Arakawa, Tokyo, Japan; 2Pathology, Nagasaki University School of Medicine, Nagasaki, Japan

370 POSTERS WEDNESDAY, JUNE 12

W111 TEMPOROSPATIAL EXPRESSION OF MMPs/TIMPs IN KIDNEY DURING AGEING OF RAT Xiang-Mei Chen, Fei Li, Guang-Yan Cai, Rong-Quan Chen, Bo Gao. Department of Nephrology, General Hospital of PLA, Beijing, China WEDNESDAY

W112 INVOLVEMENT OF MMP-2 AND -9 IN THE DEVELOPMENT OF ANTI-GBM GLOMERULONEPHRITIS IN WKY RATS Tadahide Kuroda,1,2 Yutaka Yoshida,1 Pavel Kovalenko,1 Hidehiko Fujinaka,1 Eishin Yaoita,1 Tetsuya Endo,2 Kimimasa Nakabayashi,2 Akira Yamada,2 Toshihiko Nagasawa,2 Tadashi Yamamoto.1 1Department of Structural Pathology, Institute of Nephrology, Niigata University, Niigata, Japan; 2First Department of Internal Medicine, Kyorin University, Tokyo, Japan

W113 EFFECT OF CORDYCEPS SINENSIS ON THE EXPRESSION OF BFGF IN RATS OF ARISTOLOCHIC ACID NEPHROPATHY Ying LI, MaoDong Liu, HaiYing Lin, YanQing Chi, LianFang Gu. Nephrology, Third Hospital, Hebei Medical University, Shijiazhuang, Hebai, China

W114 EXPRESSION OF BASIC FIBROBLAST GROWTH FACTOR (FGF-2) IS STRONGLY UPREGULATED IN HUMAN DIABETIC NEPHROPATHY AND IS INDUCED BY HYPERGLYCEMIA IN HUMAN RENAL FIBROBLASTS Radovan Vasko,1 Holger Schmid,2 Mathias Kretzler,2 Gerhard A. Mueller,1 Frank Strutz.1 1Nephrology and Rheumatology, Georg-August-University Medical Center, Goettingen, Germany; 2Poliklinik, LMU, Munich, Germany

W115 MOLECULAR BIOLOGIC CHANGES DURING MORPHOLOGIC PROGRESSION OF THE EXPERIMENTAL FOCAL SEGMENTAL GlOMERULOSCLEROSIS Yong-Jin Kim,1 Euny Lee,2 Yong-Hoon Park,3 Ja Hoon Koo.4 1Dept Pathology, Yeungnam Univ Coll of Med, Daegu, Korea; 2Dept Clin Pathology, Coll of Med Catholic Univ of Korea, Seoul, Korea; 3Dept Pediatrics, Yeungnam Univ Coll of Med, Daegu, Korea, 4Dept Pediatrics, School of Med, Kyungpook Nat Univ, Daegu, Korea

W116 BMP7 IS ANTI-FIBROGENIC IN MESANGIAL CELLS Shinong Wang, Raimund Hirschberg. Division of Nephrology, Research & Education Inst at Harbor UCLA- Medical Center, Torrance, CA, United States

W117 PROGRESSIVE TUBULOINTERSTITIAL LESION WITH INCREASED TUBULAR LAMININ b1 SYNTHESIS DEPENDENT ON RENIN-ANGIOTENSIN SYSTEM IN ADRIAMYCIN INDUCED NEPHROPATHY Ho-Jung Kim,1 Sang-Woong Han,1 Ho Sam Chung,2 Seung Sam Paik,3 Moon Hyang Park.3 1Division of Nephrology, Hanyang Univ. Kuri Hospital, Kuri, Kyunggi-Do, Korea; 2Anatomy, 3Pathology, Hanyang Univ. College of Medicine, Seoul, Korea

W118 RENAL MYOFIBROBLASTS PRODUCE ANGIOTENSIN II: UPREGULATION INDUCED BY IL-1b Miguel Graciano, Rita Cavaglieri, Wagner Dominguez, Humberto Delle, Irene Noronha. Nephrology, Univ. of Sao Paulo Medical School, Sao Paulo, SP, Brazil

W119 ANGIOTENSIN II INCREASES CONNECTIVE TISSUE GROWTH FACTOR IN THE KIDNEY Monica Ruperez,1 Vanesa Esteban,1 Oscar Lorenzo,1 Sergio Mezzano,2 Elsa Sanchez-Lopez,1 Juan Rodriguez-Vita,1 Jesus Egido,1 Marta Ruiz-Ortega.1 1Vascular and Renal Laboratory, Fundacion Jimenez Diaz. UAM, Madrid, Spain; 2Nephrology, Universidad Austral, Valdivia, Chile

371 WEDNESDAY, JUNE 12 POSTERS

W120 INDUCTION OF CONNECTIVE TISSUE GROWTH FACTOR (CTGF) BY ANGIOTENSIN II – COOPERATION OF SIGNALING PATHWAYS Dominika Iwanciw, Margot Rehm, Markus Porst, Margarete Goppelt-Struebe. Med. Klinik IV, Univ. Erlangen-Nürnberg, Erlangen, Germany

W121 HYPOXIA-INDUCED FIBRONECTIN IS MEDIATED BY MAP KINASES AND CONNECTIVE TISSUE GROWTH FACTOR IN HUMAN MESANGIAL CELLS: IDENTIFICATION OF MKP-1 AS A SELF-DEFENDER Qihe Xu,1 Jill T. Norman,1 Nadia N. Wahab,2 Xiongzhong Ruan,1 Ayda Yeganeh,1 Leon G. Fine,1 Masanori Kitamura.1 1Department of Medicine, Royal Free & University College Medical School, University College London, London, United Kingdom; 2Cell and Molecular Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London, United Kingdom

W122 EXPRESSION OF CONNECTIVE TISSUE GROWTH FACTOR IN MESANGIAL PROLIFERATIVE GLOMERULONEPHRITIS IN RATS Arifa Nazneen, Diange Liu, Thang Viet Le, Kojiro Ohba, Yumiko Nakashima, Mohammed S. Razzaque, Takashi Taguchi. Department of Pathology, Nagasaki University Graduate School of Biomedical Science, Nagasaki City, Nagasaki, Japan

W123 CONNECTIVE TISSUE GROWTH FACTOR SYNERGISTICALLY WITH TRANSFORMING GROWTH FACTOR-B1 TO INDUCE DOWN-REGULATION OF GELATINASE A AND MYOFIBROBLAST TRANSDIFFERENTIATION IN RENAL FIBROBLASTS Min Yang, Haichang Huang, Jingzi Li, Haiyan Wang. Division of Nephrology, First Hosp.Peking University, Beijing, China

W124 PROTEINURIA OF A PATIENT WITH MINIMAL CHANGE NEPHROTIC SYNROME CAN INDUCE EPITHELIAL- MEZENCHYMAL TRANSITION OF MDCK CELLS TYPE II IN CULTURE Sergiu Dumitrache,1 Cristiana Matache,2 Mioara Stefanescu.2 1Nephrology, “Carol Davila” Teaching Hospital of Nephrology, Bucharest, Romania; 2Immunology, “Cantacuzino” National Institute of Research and Developement for Microbiology and Immunology, Bucharest, Romania

W125 IN-VITRO TRANSDIFFERENTIATION OF ENDOTHELIAL CELLS (EDC) INTO MYOFIBROBLAST-LIKE CELLS (MFLC) STIMUATED BY CYTOKINES Manfred Sommer, Guenter Stein. Department of Internal Medicine, University of Jena, Jena, Germany

W126 GLOMERULAR FIBROSIS IS ASSOCIATED WITH EPITHELIAL- MESENCHYMAL TRANSDIFFERENTIATION (EMT) IN PAUCI- IMMUNE CRESCENTIC GLOMERULONEPHRITIS Jean Bariety, Patrick Bruneval, Gary S. Hill, Chantal Mandet, Christian Jacquot, Alain Meyrier. Nephrology, INSERM U430, Paris, France

W127 PHENOTYPIC TRANSITION OF RAT PROXIMAL TUBULAR CELLS TO MACROPHAGE-LIKE CELLS IN VIVO AND IN VITRO IDENTIFIED BY MONOCLONAL ANTIBODY ED-1 Rina Kato, Shinobu Miyazawa, Mikiko Uwano, Yasuhiro Natori. Department of Clinical Pharmacology, Research Institute, International Medical Center of Japan, Tokyo, Japan

372 POSTERS WEDNESDAY, JUNE 12

W128 PHENOTYPIC TRANSITION IN HUMAN TUBULAR EPITHELIAL CELLS INTO MACROPHAGE-LIKE CELLS IN VITRO Shinobu Miyazawa,1 Rina Kato,1 Osamu Hotta,2 Yasuhiro Natori.1 1Research Institute, International Medical Center of Japan, Tokyo, WEDNESDAY Japan; 2Department of Nephrology, Sendai Shakaihoken Hospital, Sendai, Japan

W129 EFFECTS OF IMMUNOSUPPRESANTS AND ACE INHIBITOR ON ALPORT MODEL MICE Makoto Uchiyama,1 Tatsuo Ito,2 Ichiro Satokata.2 1Division of Pediatrics, 2Division of Developmental Biology, Niigata Graduate School of Med. and Dent. Sciences, Niigata-City, Niigata Prefecture, Japan

W130 MMF IS EFFECTIVE AS ENALAPRIL IN SLOWING THE PROGRESSION OF CHRONIC ANTI-THY1 GLOMERULONEPHRITIS Stephanie Kraemer,1 Sebastian Martini,1 Raiko Woydt,1 Matthias Rueckert,1 Yingrui Wang,1 Ute Daig,1 Fuijo Shimizu,2 Hiroshi Kawachi,2 Hans-H. Neumayer,1 Harm Peters.1 1Division of Nephrology, Charité Campus Mitte, Humboldt- University Berlin, Berlin, Germany; 2Department of Cell Biology, Institue of Nephrology, Niigata University School of Medicine, Niigata, Japan

W131 MYCOPHENOLATE MOFETIL IN PREVENTION OF GLOMERULAR SCLEROSIS DEVELOPMENT IN PROGRESSIVE GLOMERULAR INJURY Ekaterina Paltseva, Olga Gladskikh, Alexei Ivanov. Cellular and Molecular Pathology, Research Institute of Molecular Medecine at Moscow Medical Academy, Moscow, Russian Federation

W132 EARLY TEMPORARY TREATMENT WITH THE AT1 BLOCKER LOSARTAN (L) COMBINED WITH MYCOPHENOLATE MOFETIL (MMF) LIMITS THE FUTURE INJURY IN THE REMNANT KIDNEY Clarice K. Fujihara, Claudia R. Sena, Luciana F. Carvalho, Glaucia R. Antunes, Denise M.A.C. Malheiros, Ana L. Mattar, Roberto Zatz. Renal Div, Dep Clin Med, University of Sao Paulo, Sao Paulo, SP, Brazil

W133 HYPERTENSION AND PROGRESSIVE RENAL INJURY INDUCED BY SALT OVERLOAD IN RATS PRECONDITIONED BY TEMPORARY NITRIC OXIDE (NO) INHIBITION Ana L. Mattar, Leonardo T. Rodrigues, Denise D.M.A.C. Malheiros, Luciana F. Carvalho, Clarice K. Fujihara, Roberto Zatz. Renal Division, Dep. Clinical Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil

W134 COMPARISON OF THE ANTIFIBROTIC AND NEPHROPROTECTIVE POTENTIAL OF ACE-INHIBITOR VERSUS AT1-ANTAGONIST IN A MURINE MODEL OF PROGRESSIVE RENAL FIBROSIS Oliver Gross, Eckhard Schulze-Lohoff, Marie-Louise Koepke, Manfred Weber. Medical Clinic I, University of Cologne, Merheim Medical Center, Cologne, Germany

W135 EFFECT OF CANDESARTAN AND PIRFENIDONE ON MORPHOLOGICAL CHANGES IN CHRONIC ANTI-GLOMERULAR BASEMENT MEMBRANE GLOMERULONEPHRITIS (ANTI-GBM GN) IN RATS Sabine Leh,1,3 Terje Forslund,2,3 Bjarne M. Iversen.3 1Dept of Pathology, Haukeland Univ. Hosp., Bergen, Norway; 2Renal Unit, Dept of Medicine, Central Finland Health District Hosp. of JyväskyläJyväskyläFinland; 3Renal Research Group, Inst. of Medicine, Univ. of Bergen, Bergen, Norway

373 WEDNESDAY, JUNE 12 POSTERS

W136 ANGIOTENSIN CONVERTING ENZYME INHIBITOR (TEMOCAPRIL) IMPROVED TUBULOINTERSTITIAL FIBROSIS IN A RAT MODEL OF PROGRESSIVE CHRONIC RENAL FAILURE INDUCED BY MICROEMBOLISM Mitsuko Asano,1 Masato Kimura,1 Mari Odamaki,2 Hiromichi Kumagai,2 Tatsuo Yamamoto,3 Akira Hishida.3 1Department of Nursing, University of Shizuoka School of Nursing, Shizuoka, Japan; 2Department of Clinical Nutrition, University of Shizuoka School of Food and Nutritional Sciences, Shizuoka, Japan; 3First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

W137 EFFECTS OF COMBINED ANGIOTENSIN II RECEPTOR BLOCKADE AND RHO KINASE INHIBITION ON GROWTH FACTOR EXPRESSION IN KIDNEYS WITH UNILATERAL URETERIC OBSTRUCTION (UUO) Silke Hessing, Cecile Dau, Dietlinde Kunz, Jun Oh, Kerstin Amann, Otto Mehls, Franz Schaefer. 1Pediatric Nephrology Division, Department of Pediatrics, Heidelberg University, Heidelberg, Germany; 2Institute of Pathology, University of Erlangen, Erlangen, Germany

W138 BENEFICIAL EFFECTS OF A STATIN MONOTHERAPY IN A NOVEL SALT-SENSITIVE HYPERTENSION MODEL OF RENAL DISEASE Leonardo T. Rodrigues, Eduardo Mantovani, Humberto Delle, Ana L. Mattar, Luciana F. Carvalho, Denise M.A.C. Malheiros, Irene L. Noronha, Clarice K. Fujihara, Roberto Zatz, Jose M. Vieira, Jr.. Renal Division, Internal Medicine, University of Sao Paulo, Sao Paulo, Brazil

W139 ANTI-FIBROSIS EFFECT OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR G GENE TRANSFECTION IN MESANGIAL CELLS Jing Sun, Ji Ma, Yong Gu, Jing Chen, Yingli Liu, Weiyu Zhu, Shanyan Lin. Division of Nephrology, Huashan Hospital, Shanghai, China

W140 ROSIGLITAZONE PREVENTS RENAL INTERSTITIAL FIBROSIS IN UNILATERAL URETERAL OBSTRUCTION RATS Qin Lin, Yong Gu, Haichun Yang, Shaojun Liu, Jing Chen, Shanyan Lin. Division of Nephrology, Huashan Hospital, Shanghai, China

W141 NON-METABOLIC EFFECTS OF PIOGLITAZONE ON PROTEINURIA AND RENAL FIBROSIS IN UNINEPHRECTOMIZED DIABETIC RATS Zhengda Sun, Yong Gu, Ji Ma, Haichun Yang, Shaojun Liu, Shanyan Lin. Division of Nephrology, Huashan Hospital, Shanghai, China

W142 TAMOXIFEN HAS PROTECTIVE EFFECT PREVENTING RENAL DAMAGE IN CHRONIC PROGRESSIVE RENAL DISEASE Humberto Delle, Jose Roberto Coelho Rocha, Denise M.A.C. Malheiros, Jose Mauro Vieira, Jr., Irene L. Noronha. Renal Division, University of Sao Paulo, Sao Paulo, SP, Brazil

W143 HALOFUGINONE PREVENTS THE OCCURENCE ON RENAL FIBROSIS IN 5/6 NEPHRECTOMIZED RATS Sydney Benchetrit,1 Shy Yarkoni,4 Mauro Rathaus,1 Marc Pines,3 Gloria Rashid,1 Joelle Bernheim,2 Jacques Bernheim.1 1Nephrology and Hypertension, Sapir Medical Center-Meir Hospital- Affiliated to Tel Aviv University, Kfar Saba, Israel; 2Pathology, Sapir Medical Center -Meir Hospital - Affiliated to Tel Aviv University, Kfar Saba, Israel; 3Institute of animal science, Agricultural Research Organization, the Volcani Center, Bet Dagan, Israel; 4Medical Research, Collgard,Biopharmaceutical Ltd, Petah Tikva, Israel

374 POSTERS WEDNESDAY, JUNE 12

RENAL HAEMODYNAMICS, VASCULAR PHYSIOLOGY, VASCULAR PATHOLOGY, EXPERIMENTAL HYPERTENSION WEDNESDAY

W144 EXTRAOSSEOUS mRNA EXPRESSION OF BONE ASSOCIATED PROTEINS IN URAEMIC MICE LACKING AHSG / FETUIN-A Ralf Westenfeld,1,2 Ralf Smeets,1 Cora Schaefer,1 Juergen Floege,2 Willi Jahnen-Dechent,1 Markus Ketteler.2 1IZKF Biomat, University Hospital, Aachen, Germany; 2Div. Nephrology & Immunology, University Hospital, Aachen, Germany

W145 ENHANCED EXPRESSION OF THE GAP JUNCTIONAL PROTEIN CONNEXIN 43 IN THE ARTERY OF THE RAT WITH EARLY STAGE RENAL FAILURE Yuri Tanaka, Yoji Inishi, Tomokatsu Saijo, Yasunori Takahashi, Hiroyasu Ishikawa, Nobuhiko Joki, Hiroki Hase. Division of Nephrology, Ohashi Hospital, Toho Univ. School of Med., Tokyo, Japan

W146 ARTERIOLAR DYSFUNCTION IN MICE WITH SYSTEMIC AUTOIMMUNE DISEASE Péter Hamar, Zsolt Bagi, Gábor Kökény, Akos Koller. Department of Pathophysiology, Semmelweis University, Budapest, Hungary

W147 EFFECTS OF LOW-DOSE SYMPATHOLYTIC TREATMENT ON CARDIOVASCULAR STRUCTURES IN EXPERIMENTAL RENAL FAILURE Karin Tyralla,1 Juergen Hofstetter,2 Andreas Koch,2 Marie-Luise Gross,2 Roland Veelken,4 Heimo Ehmke,5 Eberhard Ritz,3 Kerstin Amann.1 1Department of Pathology, University of Erlangen, Erlangen, Germany; 2Department of Pathology, University of Heidelberg, Heidelberg, Germany; 3Department of Pathology, University of Heidelberg, Heidelberg, Germany; 4Department of Pathology, University of Heidelberg, Heidelberg, Germany; 5Department of Internal Medicine, University of Heidelberg, Baden-Wuerttemberg, Germany; 6Department of Physiology, University of Heidelberg, Heidelberg, Germany; 7Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany; 8Department of Pathology, University of Erlangen, Erlangen, Germany

W148 SIGNAL TRANSDUCTION BY RHO-KINASE IN RENAL CIRCULATION Johannes Bauer,1 Niranjan Parekh.2 1Dept of Neonatology, Childrens Hospital, Univ of Heidelberg, Heidelberg, Germany; 2Dept of Physiology and Pathophysiology, Univ of Heidelberg, Heidelberg, Germany

W149 RHO KINASE IS IMPORTANTLY INVOLVED IN RENAL VASOCONSTRICTION Alessandro Cavarape,1 Nicole Endlich,2 Roberta Assaloni,1 Ettore Bartoli,3 Niranjan Parekh,4 Michael Steinhausen,2 Karlhans Endlich.2 1Dept. of Internal Medicine, University of Udine, Udine, Italy; 2Dept. of Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany; 3Dept. of Internal Medicine, University of Piemonte Orientale, Novara, Italy; 4Dept. of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany

375 WEDNESDAY, JUNE 12 POSTERS

W150 QUANTIFICATION OF GENE EXPRESSION OF THE SODIUM TRANSPORTERS NHE3, NKCC2 AND NCC ALONG THE TUBULAR NEPHRON SEGMENTS: THEIR ROLE IN THE MAINTENANCE OF GENETIC HYPERTENSION Maria Rizzo,1 Alessandra Cantone,1 Patrizia Ferrari,2 Florian Lang,3 Francesco Di Maio,1 Giuseppe Bianchi,2 Giovambattista Capasso.1 1Chair of Nephrology, Second University of Napoli, Napoli, Italy; 2Chair of Nephrology, Ateneo Vita e Salute San Raffaele Hospital, Milano, Italy; 3Department of Physiology, University of Tuebingen, Tuebingen, Germany

W151 IMPAIRED EXPRESSION OF ENDOTHELIAL CA2+-ACTIVATED K+-CHANNELS AND ENDOTHELIUM-DERIVED HYPERPOLARIZING FACTOR-MEDIATED VASODILATION IN EXPERIMENTAL CHRONIC RENAL FAILURE Ines Eichler, Susanne Brakemeier, Andrea Knorr, Ivica Grgic, Doris Kämpfe, Ralf Köhler, Joachim Hoyer. Nephrology, Univ. Medical Center Benjamin Franklin, Berlin, Germany

W152 AFFERENT RENAL NERVE FIBERS IN GENETIC AND SECONDARY HYPERTENSION Peter Linz,1 Kerstin Amann,2 Wolfgang Freisinger,1 Karl Hilgers,1 Roland Veelken.1 1Medizinische Klinik IV, University of Erlangen-Nuremberg, Erlangen, Bavaria, Germany; 2University of Erlangen-Nuremberg, Erlangen, Bavaria, Germany

W153 EFFECTS OF RENAL DENERVATION ON RENAL RESPONSES TO ENDOTHELIN-A RECEPTOR BLOCKADE IN CONSCIOUS SPONTANEOUSLY HYPERTENSIVE RATS Radoslav Girchev,1 Angela Bäcker,2 Petia Markova,1 Herbert J. Kramer.2 1Department of Physiology, Medical Faculty, University of Sofia, Sofia, Bulgaria; 2Renal Section, Medical Policlinic, University of Bonn, Bonn, Germany

W154 INTERACTION OF RENAL NERVES WITH THE RENAL ENDOTHELIN (ET) SYSTEM IN NORMOTENSIVE WISTAR- KYOTO (WKY) AND SPONTANEOUSLY HYPERTENSIVE RATS (SHR) Herbert J. Kramer,1 Angela Bäcker,1 Dirk Bokemeyer,1 Radoslav Girchev.2 1Renal Section, Medical Policlinic, University of Bonn, Bonn, Germany; 2Department of Physiology, Medical Faculty, University of Sofia, Sofia, Bulgaria

W155 STIMULATION OF RENAL KALLIKREIN-KININ SYSTEM (KKS) WITH POTASSIUM REDUCES HYPERTENSION IN RATS WITH OVERLOAD PROTEINURIA Leopoldo Ardiles,1 Fernando Loyola,1 Alvaro Ojeda,1 Carlos Figueroa,2 Pamela Ehrenfeld,2 Maria Burgos,1 Claudio Flores,1 Italo Caorsi,2 Graciela Valderrama,1 Jesús Egido,3 Sergio Mezzano.1 1Nephrology, Universidad Austral, Valdivia, Chile; 2Histology and Pathology, Universidad Austral, Valdivia, Chile; 3Nephrology, Fundación Jimenez Diaz,UAM, Madrid, Spain

W156 RENAL FUNCTION AND AUTOREGULATION OF BLOOD FLOW IN ISOLATED PERFUSED MOUSE KIDNEY Majid Rahgozar,1 Zhengrong Guan,1 Anita Matthias,1 Glenda Gobe,2 Zoltan Endre.1 1Department of Medicine, University of Queensland, Brisbane, Queensland, Australia; 2Department of Pathology, University of Queensland, Brisbane, Queensland, Australia

376 POSTERS WEDNESDAY, JUNE 12

W157 REAL-TIME OBSERVATION OF HEMODYNAMIC CHANGES IN GLOMERULAR LESIONS WITH PROGRESSIVE GLOMERULOSCLEROSIS Kazuko Kawamura,1 Bing Li,1 Michihiro Suwa,1 Jian Yao,1 Tetsuo WEDNESDAY Morioka,1 Fumitake Gejyo,2 Takashi Oite.1 1Department of Cellular Physiology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; 2Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

W158 RENAL FUNCTION IN RATS SUBJECTED TO PRE-NATAL MALNUTRITION AND RENAL MASS REDUCTION DURING ADULT LIFE João P.C. Martins, José L.J. Silva, Josélia C. Monteiro, Ana D.O. Paixão. Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil

W159 THE IMPACT OF GENDER ON PROGRESSION OF RENAL DISEASE: POTENTIAL ROLE OF ESTRGEN-MEDIATED VEGF REGULATION AND VASCULAR PROTECTION Duk-Hee Kang,1 Jung-Eun Park,1 Richard Johnson,2 Kyun-Il Yoon.1 1Division of Nephrology, Ewha Women’s University College of Medicine, Seoul, Korea; 2Division of Nephrology, Baylor College of Medicine, Houston, TX, United States

W160 STRAIN DIFFERENCES IN THE DEVELOPMENT OF HYPERTENSION AND GLOMERULAR LESIONS INDUCED BY DEOXYCORTICOSTERONE ACETATE-SALT IN MICE Andrea Hartner, Nada Cordasic, Bernd Klanke, Roland Veelken, Karl F. Hilgers. Medizinische Klinik IV, Universität Erlangen-Nürnberg, Erlangen, Germany

W161 INTRARENAL SYNTHETIC MACHINERY AND RELEASE OF PROSTAGLANDIN E2 Janos Peti-Peterdi,1 Amanda Fuson,1 Peter Komlosi,1 Tino Unlap,1 Matthew Breyer,2 Phillip Bell.1 1Dept. of Medicine, Div. of Nephrology, University of Alabama at Birmingham, Birmingham, AL, United States; 2Dept. of Medicine, Div. of Nephrology, Vanderbilt University, Nashville, TN, USA

W162 RENAL CORTICAL ENZYMES FOR PROSTAGLANDIN SYNTHESIS IN THE GOLDBLATT MODEL - EFFECTS OF ANGIOTENSIN AND BRADYKININ F. Theilig,1 N. Bouby,3 B. Nafz,2 R. Nuesing,4 P. Ronco,5 S. Bachmann.1 1Anatomy, Charite, Humboldt-Univ., Berlin, Germany; 2Physiology, Charite, Humboldt-Univ., Berlin, Germany; 3Physiology, Inserm U 367, Paris, France; 4Department of Pediatrics, Philipps Univ., Marburg, Germany; 5Inserm U489, Hopital Tenon, Paris, France

W163 KIDNEY WEIGHT AND PROGRESSION OF ADRIAMYCIN NEPHROPATHY IN SPONTANEOUSLY HYPERTENSIVE RATS Dijana Jovanovic,1 Djurdjica Jovovic,2 Nevena Mihailovic- Stanojevic,2 Jovan Dimitrijevic,1 Nebojsa Maksic,3 Ljubica Djukanovic.1 1Clinic of Nephrology, Institute of Urology and Nephrology, Belgrade, Yugoslavia; 2Institute for Medical Research, Belgrade, Yugoslavia; 3Institute of Medical Biochemistry, Belgrade, Yugoslavia

W164 TUBULOGLOMERULAR FEEDBACK IN THE EFFERENT ARTERIOLE Koichiro Homma, Koichi Hayashi, Shu Wakino, Takeshi Kanda, Kyoko Yoshioka, Ichiro Takamatsu, Satoru Tatematsu, Takao Saruta. Internal Medicine, Keio University, Shinanomachi Shinjyuku-ku, Tokyo, Japan

377 WEDNESDAY, JUNE 12 POSTERS

W165 CHARACTERIZATION OF INCREASED GLOMERULAR ALBUMIN PERMEABILITY IN OLD SPONTANEOUSLY HYPERTENSIVE RATS (SHR) Omran Bakoush,1 Jan Tencer,1 Ole Torffvit,2 Ingela Skogvall,1 Bengt Rippe.3 1Nephr., Lund Univ. Hosp., Lund, Sweden; 2Med., Lund Univ.Hosp., Lund, Sweden

W166 EXPRESSION OF HEAT SHOCK PROTEIN (HSP) IS DIFFERENTIALLY REGULATED IN TWO-KIDNEY, ONE CLIP (2K1C) AND DEOXYCORTICOSTERONE ACETATE (DOCA)-SALT HYPERTENSION Ki Chul Choi,1 YoonWha Oh,2 Nam Ho Kim,1 Soo Wan Kim,1 JongUn Lee.2 1Internal Med., Chonnam National Univ. Medical School, Gwangju, Korea; 2Physiology, Chonnam National Univ. Med. School, Gwangju, Korea

W167 DIRECT EVIDENCE FOR RENAL MICROVASCULAR ENDOTHELIAL DYSFUNCTION IN CHRONIC RENAL Ken Okubo, Koichi Hayashi, Shu Wakino, Hiroto Matsuda, Eiji Kubota, Masanori Honda, Hironobu Tokuyama, Takao Saruta. Department of Internal Medicine, Keio University, Tokyo, Japan

W168 SALT INDUCED HYPERTENSION ELIMINATES FEMALE PROTECTION AGAINST INCREASED ALBUMINURIA IN RATS Larisa Kovacevic,1,2 Angela Schulz,2 Reinhold Kreutz.2 1Nephrology, Children’s Hospital of Michigan, Detroit, MI, USA; 2Clinical Pharmacology, Benjamin Franklin Hosp., Berlin, Germany

W169 EFFECTS OF VASOPEPTIDASE INHIBITOR, OMAPATRILAT, ON RENAL MICROCIRCULATION IN SHR Masahiko Kawabata, Tao Wang, Manabu Haneda, Toshikazu Takabatake. Internal Med. (IV), Shimane Medical Univ., Izumo, Shimane, Japan

W170 TREATMENT OF HYPERTENSIVE NEPHROPATHY BY THE NOVEL VASOPEPTIDASE INHIBITOR AVE7688: NEPHROPROTECTION BEYOND ACE INHIBITION ALONE Stefan Schäfer,1 Wolfgang Linz,1 Afkham Freni,1 Hartmut Rütten,1 Hans-Ludwig Schmidts,2 Andreas E. Busch,1 Markus Bleich.1 1DG Cardiovascular Diseases, Aventis Pharma Deutschland, Frankfurt am Main, Germany; 2Drug Safety Evaluation, Aventis Pharma Deutschland, Hattersheim, Germany

W171 ETA/B RECEPTOR BLOCKADE EXACERBATES ALBUMINURIA IN RENIN-DEPENDENT HYPERTENSION Lars Rothermund,1,2 Peter Kossmehl,1 Daniela Grimm,1 Martin Paul,1 Reinhold Kreutz.1,2 1Medicine IV Nephrology, Freie Universitaet, Berlin, Germany; 2Clinical Pharmacology and Toxicology, Freie Univ., Berlin, Germany

W172 EFFECTS OF ALLOPURINOL ON THE RENAL INJURY INDUCED BY A HIGH-CHOLESTEROL DIET IN RATS Masao Takagi,1 Keiichiro Atarashi,2 Akihiro Ishiyama,1 Mayumi Minami.2 1Dept of Internal Med., Tokyo Metropol.Police Hosp., Tokyo, Japan; 2The 2nd Dept of Internal Med., Faculty of Med., Univ. of Tokyo, Tokyo, Japan

W173 CHRONIC CYCLOOXYGENASE-2 INHIBITION DOES NOT ALTER BLOOD PRESSURE AND KIDNEY FUNCTION IN RENOVASCULAR HYPERTENSIVE RATS Claus-M. Richter,1 Michael Godes,1 Christian Bauer,2 Hans-H. Neumayer,1 Berthold Hocher.1 1Dept. of Nephrology, Charité Campus Mitte, Berlin, Germany; 2Dept. of Molecular Biology and Biochemstry, Free Univ. of Berlin, Berlin, Germany

378 POSTERS WEDNESDAY, JUNE 12

W174 EFFECTS OF EXERCISE TRAINING AND ANGIOTENSIN CONVERTING ENZYME INHIBITION IN FRUCTOSE-FED RATS Kazunori Yoshida,1 Takayuki Kawamura,2 Hong-Lan Xu,2 Lina Ji,2 Masahiro Kohzuki.2 WEDNESDAY 1Department of Internal Medicine, Furukawa City Hospital, Furukawa, Miyagi, Japan; 2Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

W175 GOVERNANCE OF ARTERIOLAR OSCILLATION BY RYANODINE RECEPTORS Tsuneo Takenaka,1 Yoichi Ohno,2 Koichi Hayashi,2 Takao Saruta,2 Hiromichi Suzuki.1 1Department of Medicine, Saitama Medical College, Iruma, Saitama, Japan; 2Department of Medicine, Keio University, School of Medicine, Shinjuku, Tokyo, Japan

W176 COCAINE ENHANCES HIV-1 INFECTION IN HUMAN KIDNEY CELLS VIA UPREGULATION OF GalCer RECEPTOR Junli Zah, H. Chen, Harry Ward. 1Division of Nephrology, King/Drew Medical Center, Los Angeles, CA, United States; 2Medicine, UCLA School of Medicine, Los Angeles, CA, United States

W177 ROLE OF WNK KINASES IN HYPERTENSIVE RAT STRAINS Hakan Toka, Kristopher Kahle, Frederick Wilson, Carol Nelson- Williams, Richard Lifton. Genetics, Yale University, New Haven, CT, United States

W178 INFLUENCE OF PREPUBERAL GONADECTOMY IN THE DEVELOPMENT OF HYPERTENSION IN SHR. RELATION WITH THE KALLIKREIN-KININ AND RENIN ANGIOTENSIN SYSTEMS Elisabet Oddo, Verónica De Luca, Horacio Herrera, Rodolfo Martin, Fernando Ibarra, Elvira Arrizurieta. Instituto de Investigaciones Médicas Alfredo Lanari, Facultad de Medicina,Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

W179 INDUCEMENT OF SALT-SENSITIVE HYPERTENSION BY CHRONIC REDUCTION OF CAROTID BLOOD FLOW Masato Nishimura,1 Hakuo Takahashi,2 Toshihiko Ono.3 1Cardiovascular Division, Toujinkai Hospital, Kyoto, Japan; 2Clinical Sciences and Laboratory Medicine, Kansai Medical University, Moriguchi, Osaka, Japan; 3Division of Urology, Toujinkai Hospital, Kyoto, Japan

W180 ENDOTHELIAL DYSFUNCTION DOES NOT ACCOUNT FOR SALT-INDUCED HYPERTENSION IN ENDOTHELIN-B RECEPTOR-DEFICIENT MICE Thomas Quaschning,1 Christoph Wunderlich,1 Christoph Wanner,1 Michael Richter,2 Hans-H. Neumayer,2 Jan Galle,1 Masashi Yanagisawa.3 1Department of Nephrology, University Hospital Würzburg, Würzburg, Germany; 2Department of Nephrology, University Hospital Charite, Berlin, Germany; 3Department of Molecular Genetics, University of Texas, Dallas, TX, United States

W181 THE EFFECT OF GENDER AND SEXUAL STEROIDS ON RENAL ISCHAEMIA-REPERFUSION INJURY Veronika Muller,1 Gyorgy Losonczy,1 Uwe Heemann,3 Andrea Fekete,2 Adam Vannay,2 Gyorgy Reusz,2 Tivadar Tulassay,2 Attila Szabo.2 1Pulmonology, Semmelweis University, Budapest, Hungary; 2I. Dept. of Pediatrics, Semmelweis University, Budapest, Hungary; 3Nephrology, Universitatsklinikum Essen, Essen, Germany

379 WEDNESDAY, JUNE 12 POSTERS

W182 ROLE OF ANGIOTENSIN II (ANG II), ENDOTHELIN (ET), NITRIC OXIDE (NO), AND PROSTAGLANDINS (PG’S) IN THE MAINTENANCE OF SYSTEMIC AND PULMONARY HAEMODYNAMICS AND RENAL FUNCTION Carlos Gomez Alamillo,1 Luis Juncos,2 Aleix Cases Amenos,1 J. Carlos Romero.1 1Physiology & Biophysics, Mayo School of Medicine and Mayo Clinic, Rochester, MN, United States; 2Division of Nephrology, Mayo School of Medicine and Mayo Clinic, Rochester, MN, United States

W183 HYPERTENSION, SODIUM RETENTION, CALCIUM EXCRETION AND OSTEOPENIA IN DAHL RATS Jens Titze,1 Jörn Rittweger,2 Peter Dietsch,3 Karl-Heinz Schwind,4 Karl A. Kirsch,2 Karl F. Hilgers.1 1Nephrology, Friedrich Alexander University Erlangen-Nürnberg, Erlangen, Germany; 2Physiology, Free University Berlin, Berlin, Germany; 3Biochemistry, Free University Berlin, Berlin, Germany; 4Physics and Chemistry, Federal Center for Meat Research, Kulmbach, Germany

W184 IF THE RACE OF EXPERIMENTAL ANIMALS MIGHT BE THE MAIN FACTOR RESPONSIBLE FOR DEVELOPMENT OF RENAL FAILURE IN ANIMAL MODEL OF HEPATORENAL SYNDROME (HRS)? Marek Saracyn,1 Ewa Pirozynska,2 Wojciech Kozlowski,2 Zofia Wankowicz.1 1Nephrology, Military Institute of Medicine, Warsaw, Poland; 2Clinical Pathomorphology, Military Institute of Medicine, Warsaw, Poland

W185 POSTISCHAEMIC ACUTE RENAL FAILURE IS NOT ENDOTHELIN-MEDIATED IN CONDITIONS WITH STRONG NITRIC OXIDE INHIBITION Zoran Miloradovic,1 Djurdjica Jovovic,1 Mirjana Jerkic,2 Nevena Mihailovic-Stanojevic.1 1Laboratory for Cardiovascular Research, Institute for Medical Research, Belgrade, Serbia, Yugoslavia; 2Departamento de Fisiologia y Farmacologia, Facultad de Medicina,Universidad de Salamanca, Salamanca, Spain

W186 LEPTIN AND ENDOTOXEMIA-INDUCED ACUTE RENAL FAILURE Wei Wang, Brian Poole, Sandor Falk, Gengaro Patricia, Robert Schrier. Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, United States

W187 ROLE OF IL-18 IN ENDOTOXEMIA-INDUCED ACUTE RENAL FAILURE Wei Wang,1 Brian Poole,1 Sandor Falk,1 Ping Li,2 Lili Feng,2 Vyacheslav Melinkov,1 Edelstein Charles,1 Robert Schrier.1 1Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, United States; 2Department of Medicine, Baylor College of Medicine, Houston, TX, United States

W188 TEMPORAL EFFECTS OF BRAIN DEATH ON KIDNEY FUNCTION Terezia B. Andrasi,1 Pal Soos,1 Ulrike Heger,2 Susanne Mandera,2 Nicole Stumpf,2 Gabor Szabo.2 1Department of Cardiovascular Surgery, Semmelweis University, Budapest, Hungary; 2Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany

380 POSTERS WEDNESDAY, JUNE 12

MISCELLANEOUS TUBULAR CELL FUNCTION WEDNESDAY

W189 ALBUMIN HANDLING AND MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) PRODUCTION BY HUMAN RENAL PROXIMAL TUBULE CELLS Steven McTaggart,1,2 Colin Jones,1 Peter Harris.2 1Department of Nephrology, Royal Children’s Hospital, Melbourne, Victoria, Australia; 2Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia

W190 A TRANSCELLULAR RETRIEVAL PATHWAY MAINTAINS LOW RENAL ELIMINATION OF PLASMA ALBUMIN Julijana Nikolovski, Maria Koltun, Wayne Comper. Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

W191 LOW MOLECULAR WEIGHT PROTEINURIA ASSOCIATED WITH PUROMYCIN AMINONUCLEOSIDE NEPHROSIS IS CAUSED BY INHIBITION OF THE RENAL LYSOSOMAL DEGRADATION PATHWAY Julijana Nikolovski, Wayne Comper. Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

W192 O2 AFFINITY OF CROSS-LINKED HEMOGLOBIN BLOOD SUBSTITUTES MODIFIES O2 METABOLISM IN RAT PROXIMAL TUBULE FRAGMENTS Andrew Baines, Patrick Ho. Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

W193 IMMUNOLOCALIZATION OF METALLOTHIONEIN ALONG THE RAT NEPHRON Mario Skarica, Carol M. Herak-Kramberger, Ivan Sabolic. Unit of Molecular Toxicology, Institute for Medical Research and Occupational Health, Zagreb, Croatia

W194 STEADY STATE mRNA, PROTEIN LEVELS AND IMMUNOHISTOCHEMISTRY OF EPITHELIAL SODIUM CHANNEL (ENaC) SUBUNITS IN BILE DUCT LIGATED RATS Bruno Vogt,1 Andreas Serra,1 Zhenrong Yu,1 Daniel Sauter,2 Johannes Loffing,2 Felix J. Frey,1 Brigitte M. Frey.1 1Nephrology/Hypertension, Inselspital/University Hospital, Berne, Switzerland; 2Anatomy, University of Zuerich, Zuerich, Berne, Switzerland

PRIMARY HUMAN RENAL TUBULAR EPITHELIAL CELLS W195 AFTER SIX WEEKS OF QUIESCENT CULTURE RETAIN F-ACTIN CYTOSKELETON AND MAINTAIN cAMP RESPONSE TO RENAL HORMONES Tim Leach,1,2 Sara Campbell,1,2 Paul Bass,2 Juan Mason,1 Janet Albano.1,2 1Wessex Renal & Transplant Unit, Queen Alexandra Hospital, Portsmouth, Hampshire, United Kingdom; 2Renal Research, University of Southampton School of Medicine, Southampton, Hampshire, United Kingdom

W196 COMPLEMENT ACTIVATION REGULATES THE CAPACITY OF PROXIMAL TUBULAR EPITHELIAL CELLS TO STIMULATE ALLOREACTIVE T CELLS Wuding Zhou, Ke Li, Hetal Patel, Conrad Farrar, Stipo Jurcevic, Steven H. Sacks. Nephrology and Transplantation, Guy’s Hospital, London, United Kingdom

381 WEDNESDAY, JUNE 12 POSTERS

W197 EXPRESSION OF NOVEL COMPLEMENT REGULATORY MOLECULES ON THE CELL SURFACE OF HUMAN URINARY TRACT EPITHELIAL CELLS Ke Li, Wuding Zhou, Steven Sacks, Neil Sheerin. Nephrology and Transplantation, Guy’s Hospital, King’s College London, London, United Kingdom

W198 IMMUNOMODULATORY EFFECTS OF STATINS ON HUMAN RENAL TUBULAR CELLS Martin Nitschke, Ingrid Mangels, Wolfram J. Jabs, Juergen Steinhoff. Med. Klinik I, Nephrology, University of Luebeck School of Medicine, Luebeck, Germany

W199 EPIDERMAL GROWTH FACTOR ACTIVATES C-RAF, ERK-MAPK AND STAT5 AND INDUCES EXPRESSION OF PLASMINOGEN ACTIVATOR INHIBITOR-1 AND TRANSFORMING GROWTH FACTOR BETA IN RAT RENAL EPITHELIAL CELLS Jens Gaedeke,1 Nancy A. Noble,2 Wayne A. Border.2 1Medizinische Klinik m.S. Nephrologie, CharitéCampus Mitte, Berlin, Germany; 2Fibrosis Research Laboratory, University of Utah, Salt Lake City, UT, United States

W200 REGULATION OF THE ALPHA-SMOOTH MUSCLE ACTIN (SMA) PROMOTER BY TRANSFORMING GROWTH FACTOR BETA IN RENAL TUBULAR CELLS Attila Fintha,1 Suvi-Katri Leivonen,2 Andras Masszi,1,3 Caterina di Ciano,3 Attila Sebe,1 Laszlo Rosivall,1 Andras Kapus,3 Veli-Matti Kahari,2 Istvan Mucsi.1,4 1Hungarian Academy of Sciences and Semmelweis University Nephrology Research Group, Semmelweis University, Budapest, Hungary; 2Centre for Biotechnology, University of Turku, Turku, Finland; 3Dept. of Surgery, University Health Network, Toronto, ON, Canada

W201 PROXIMAL TUBULE CELLS IN PRIMARY CULTURE, A MODEL TO STUDY CHRONIC CADMIUM EXPOSURE AND INTERSTITIAL FIBROSIS. TRANSDIFFERENTIATION TO MYOFIBROBLASTS OCCURS IN THE PRESENCE OF TGF-β1 Sara Terryn,1 Frank Vandenabeele,3 Marjan Moreels,3 Paul Steels,2 Emmy Van Kerkhove.1 1MBW-Laboratory of Cell Physiology, LUC/tUL, BIOMED (Biomedisch Onderzoeksinstituut) / CMK (Centrum voor Milieukunde), Diepenbeek, Belgium; 2MBW-Laboratory of Cell Physiology, LUC/tUL,BIOMED, Diepenbeek, Belgium; 3MBW- Laboratory of Histology, LUC/tUL, BIOMED, Diepenbeek, Belgium

W202 CYTOTOXIC ASPECTS INVOLVING THE ACTIVITIES OF HUMAN AND RAT Na,K-ATPases: COMPARATIVE EFFECTS OF IOPAMIDOL, CYCLOSPIRIN A AND AMIKACIN Marcos Barnese,1 Caroline Martins,1 Fabricio Bino,1 Mauro Castro- Faria,2 Mauricio Younes-Ibrahim.1 1Medicine - Nephrology Unit, Universidade Estado do Rio de Janeiro, Rio de Janeiro, Brazil; 2Cell Biology, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

W203 IN VITRO NEPHROTOXICITY IN PROXIMAL TUBULE CELLS FROM INDIVIDUALS OF KNOWN N-ACETYLTRANSFERASE GENOTYPE Debbie Marsden,1 Jon Lyon,2 Peter Lord,2 Uzma Atif,2 Paul Whiting,1 Simon Oldroyd.1 1School of Molecular Sciences, De Montfort University, Leicester, Leicestershire, United Kingdom; 2Safety Assessment Department, GlaxoSmithKline, The Frythe, Welwyn, Hertfordshire, United Kingdom

382 POSTERS WEDNESDAY, JUNE 12

MISCELLANEOUS ARRAYS AND PROTEONOMICS WEDNESDAY

W204 A NIF3L1 SPLICE VARIANT PREDOMINANTLY EXPRESSED IN HUMAN GLOMERULI Wolfgang Fierlbeck,1 Jenny Sorensson,2 Barbara J. Ballermann.3 1Nephrology, JWG-University, Frankfurt, Germany; 2Nephrology, Goteborg University, Goteborg, Sweden; 3Nephrology, Albert Einstein College of Medicine, Bronx, NY, United States

W205 PROTEIN EXPRESSION IN THE COURSE OF EXPERIMENTAL GLOMERULONEPHRITIS USING PROTEOMICS APPROACH Khurram Nazeer, John Arthur, Martha Swartz, Milos Budisavljevic. Medicine/Nephrology, Medical University of South Carolina, Charleston, SC, United States

W206 THE USE OF GENE CHIP TECHNOLOGY FOR THE CHARACTERIZATION OF THE REGULATION OF RENAL TRANSPORT PROCESSES AND OF NEPHROTOXICITY IN RATS Christian Fleck,1 Dorothea Appenroth,1 Laura Suter,2 Berit Koch,1 Tobias Meinhold,1 Melanie Pitack,1 Rodolfo Gasser.2 1Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, Thuringia, Germany; 2Nonclinical Safety (PRNS), Hoffmann-La Roche AG, Basle, Switzerland

W207 COMPARISON OF GENE TRANSCRIPTION INDUCED IN RENAL TUBULAR CELLS BY TWO HOMOLOGOUS SCATTER FACTORS, HEPATOCYTE GROWTH FACTOR (HGF) AND MACROPHAGE STIMULATING PROTEIN (MSP). A c-DNA MICROARRAY STUDY Teresa Rampino,1 Milena Maggio,1 Massimo Broggini,2 Sergio Marchini,2 Riccardo Bonomi,2 Andrea Ranghino,1 Cristina Guidetti,1 Grazia Soccio,1 Marilena Gregorini,1 Antonio Dal Canton.1 1Nephrology Dialysis Transplantation, University and Policlinico San Matteo, Pavia, Italy; 2Oncology, Mario Negri, Milano, Italy

W208 GENE TRANSCRIPTION INDUCED BY HEPATOCYTE GROWTH FACTOR (HGF) IN RENAL TUBULAR CELLS. A c-DNA MICROARRAY STUDY Teresa Rampino,1 Milena Maggio,1 Massimo Broggini,2 Sergio Marchini,2 Riccardo Bonomi,2 Andrea Ranghino,1 Cristina Guidetti,1 Grazia Soccio,1 Marilena Gregorini,1 Antonio Dal Canton.1 1Nephrology Dialysis Transplantation, University and Policlinico San Matteo, Pavia, Italy; 2Oncology, Mario Negri, Milano, Italy

W209 IDENTIFICATION OF REGULATED GENES BY THE INDUCTION OF HEME OXYGENASE-1 (HO-1) IN A RAT ISCHAEMIA/ REPERFUSION INJURY MODEL USING CDNA MICROARRAYS Katja Kotsch,1 Paulo N.A. Martins,2 Annelie Dernier,1 Katrin Vogt,1 Uwe Janssen,3 Bernhard Gerstmayer,3 Birgit Sawitzki,4 Roman Klemz,1 Anja Reutzel-Selke,2 Hans-Dieter Volk,1 Stefan G. Tullius.2 1Institute of Medical Immunology, CahritéHumboldt-University, Berlin, Germany; 2Department of Surgery, Virchow-Clinic, CharitéHumboldt-University, Berlin, Germany; 3Memorec Stoffel GMBH, Cologne, Germany; 4Nuffield Department of Surgery, John Radcliff Hospital, Oxford University, Oxford, Germany

383 WEDNESDAY, JUNE 12 POSTERS

GENERAL NEPHROLOGY PRIMARY GLOMERULAR DISEASES: CLINICAL

W210 TNF-A2 AND d2 ALLELES OF TNF-ALPHA GENE POLYMORPHISM ARE ASSOCIATED WITH ONSET OF IMN (IDIOPATHIC MEMBRANOUS NEPHROPATHY) D. Thibaudin, P. Berthoux, L. Thibaudin, V. Bin, C. Mariat, J.P. de Filippis, B. Laurent, E. Alamartine. Nephrology, CHU de Saint-Etienne, Saint-Etienne, France

W211 FAMILIAL MEMBRANOUS NEPHROPATHY — AN ANALYSIS OF 3 KINDRED AND LITERATURES REVIEW Hong Zhang,1 Jicheng Lv,1 Gang Liu,1 Zhangsuo Liu,2 Yuchun Liu,1 Haiyan Wang.1 1Renal Division, First Hospital of Peking University, Beijing, China; 2Renal Division, First Hospital of Zhengzhou University, Zhengzhou, Henan, China

W212 PECAM-1 GENE POLYMORPHISMS IN PATIENTS WITH MEMBRANOUS NEPHROPATHY Shoji Kuwata, Tomohiro Morio, Akira Yamami, Senichiro Ooki, Takashi Arai. Third Dept Internal Medicine, Teikyo Univetsity School of Medicine Ichihara Hospital, Ichihara, Chiba, Japan

W213 UP-REGULATION OF INTERLEUKIN-4 PRODUCTION OF PERIPHERAL CD4+ T-CELLS IN IDIOPATHIC MEMBRANOUS NEPHROPATHY Kohsuke Masutani,1 Masatomo Taniguchi,1 Hitoshi Nakashima,2 Mitsuteru Akahoshi,2 Tsutomu Kohsaka,3 Kazuhiko Tsuruya,1 Kyoichi Fukuda,1 Hidetoshi Kanai,1 Hideki Hirakata,1 Mitsuo Iida.1 1Dept of Medicine and Clinical Science, 2Dept of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; 3Otsuka Tokyo Assay Lab, Tokyo, Japan

W214 URINARY EXCRETION OF b2-MICROGLOBULIN AND IGG PREDICT PROGNOSIS IN IDIOPATHIC MEMBRANOUS NEPHROPATHY: A VALIDATION STUDY Amanda Branten,1 Peggy Du Buf-Vereijken,1 Geert Feith,2 Daan Hollander,3 Frank Bosch,4 Jack Wetzels.1 1Nephrology, UMC Nijmegen, Nijmegen, Netherlands; 2Internal Medicine, Hospital Gelderse Vallei, Ede, Netherlands; 3Internal Medicine, Jeroen Bosch Hospital, ‘s Hertogenbosch, Netherlands; 4Internal Medicine, Hospital Rijnstate, Arnhem, Netherlands

W215 RESTRICTIVE USE OF IMMUNOSUPPRESSIVE TREATMENT IN PATIENTS WITH IDIOPATHIC MEMBRANOUS NEPHROPATHY: EXCELLENT RENAL SURVIVAL IN A LARGE PATIENT COHORT Peggy du Buf - Vereijken,1 Geert Feith,2 Daan Hollander,3 Paul Gerlag,4 Joris Wirtz,5 Ton Noordzij,6 Jack Wetzels.1 1Nephrology, Univ. Medical Ctr St. Radboud, Nijmegen, Netherlands; 2Internal Medicine, Hosp. Gelderse Vallei, Ede, Netherlands; 3Internal Medicine, Jeroen Bosch Ctr ‘s Hertogenbosch, Netherlands; 4Internal Medicine, Maxima Medical Ctr, Veldhoven, Netherlands; 5Internal Medicine, Laurentius Hosp., Roermond, Netherlands; 6Internal Medicine, Franciscus Hosp., Roosendaal, Netherlands

W216 PONTICELLI REGIME FOR MEMBRANOUS NEPHROPATHY – DO INDIANS RESPOND DIFFERENTLY? Kishen A. Gopal,1 Manisha Sahay,2 Anuradha Raman,2 Girish Narayen.2 1Dept of Nephrology, Mediciti Hospitals, Hyderabad, Andhra Pradesh, India; 2Department of Nephrology, Osmania General Hospital, Hyderabad, Andhra Pradesh, India

384 POSTERS WEDNESDAY, JUNE 12

W217 TREATMENT FOR IDIOPATHIC MEMBRANOUS NEPHROPATHY: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIAL EVIDENCE Giovanni F.M. Strippoli,1 Angela Webster,1,3 Carlo Manno,2 WEDNESDAY Francesco P. Schena,2 Jonathan C. Craig.1,3 1Centre for Kidney Research, Cochrane Renal Group-The Children’s Hospital at Westmead, Westmead, NSW, Australia; 2Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy; 3School of Public Health, University of Sydney, Australia

W218 THE EFFICACY OF CYCLOSPORIN FOR PATIENTS WITH IDIOPATHIC AND LUPUS MEMBRANOUS NEPHROPATHY: A COMPARATIVE ANALYSIS Pornthep Leelasa-nguan,1 Vasant Sumethkul,1 Supalerk Pattanaprichakul,1 Sasivimol Rattanasiri,2 Panas Chalermsanyakorn.3 1Medicine, Ramathibodi Hospital, Bangkok, Thailand; 2Clinical Epidemiology, Ramathibodi Hospital, Bangkok, Thailand; 3Pathology, Ramathibodi Hospital, Bangkok, Thailand

W219 PREVALENCE AND TREATMENT OF IDIOPATHIC MEMBRANOUS GLOMERULONEPHRITIS IN PATIENTS WITH NEPHROTIC SYNDROME Styliani Giannakaki, Maria Mylonopoulou, Maria Tsilivigou, Athena Demetriou, Gabriel Papadakis. Department of Nephrology, Tzanio General Hospital, Piraeus, Greece

W220 PREDICTING OF PROGNOSTIC RENAL DYSFUNCTION BY THE RENAL EXPRESSION OF ALPHA-SMOOTH MUSCLE ACTIN AND CD68 POSITIVE CELL IN CHILDREN WITH MPGN Junzo Suzuki, Yukihiko Kawasaki, Ruriko Nozawa, Shigeo Suzuki, Hitoshi Suzuki. Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima-City, Fukushima, Japan

W221 IMBALANCE OF TH1/TH2 LYMPHOCYTES IN PATIENTS WITH MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS HEPATITIS-C RELATED Carmelo Libetta,1 Manuela Zucchi,1 Elena Gori,1 Vincenzo Sepe,1 Federica Meloni,2 Antonio Dal Canton.1 1Nephrology, Dialysis and Transplantation, University and IRCCS Policlinico S. Matteo, Pavia, Italy; 2Respiratory Disease, IRCCS Policlinico S. Matteo, Pavia, Italy

W222 THE DIFFERENTIAL DISTRIBUTION OF PERMEABILITY FACTORS IN CRYOPRECIPITATE AND SUPERNATANT MAY BE ASSOCIATED WITH THE PATHOGENESIS OF HEPATITIS C-ASSOCIATED MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS Mary Artero,1 Michele Carraro,1 Cristina Zennaro,1,2 Emanuela Boer,1 Gabriele Pozzato,1 Francesca Zorat,1 Fabiana Nascimben,1 Francesco Scolari,3 Consuelo Mazzucchelli,3 Luigi Faccini.1 1Department of Medicina Clinica and Neurology, University of Trieste, Trieste, Italy; 2Department BBCM, University of Trieste, Trieste, Italy; 3Cattedra of Nephrology, University of Brescia, Brescia, Italy

W223 CLINICAL ASPECTS OF PRIMARY MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS (GNMP) AND WITH VIRUS C INFECTION Renata Kelly Pantoja, Luiz Claudio Pinto, Marilia Bahiense-Oliveira, Patricia Malafronte, Rui T. Barros, Viktoria Woronik. Division of Nephrology, Hospital das Clinicas University of Sao Paulo, Sao Paulo, SP, Brazil

385 WEDNESDAY, JUNE 12 POSTERS

W224 TREATMENT OF MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS PRESENTING WITH NEPHROTIC SYNDROME Violeta Rabrenovic,1 Zoran Kovacevic,1 Milorad Rabrenovic,2 Veselin Skataric,1 Rajko Hrvacevic,1 Dragan Jovanovic.1 1Department of Nephrology, Military Medical Academy, Belgrade, Serbia, Yugoslavia; 2Department of Treatment, Military Medical Academy, Belgrade, Serbia, Yugoslavia

W225 MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS ASSOCIATED WITH SULFUR MUSTARD (HD): A REPORT OF THREE CASES FROM IRAN Behzad Einollahi,1 Vahid Pourfarziani,1 Mohamad Javad Hoseini Akbari,2 Behzad Hajarizadeh.1 1Nephrology, 2Pathology, Baghyatollah University of Medical Sciences, Tehran, Iran

W226 PREDISPOSING INFECTIONS AND THEIR SEASONAL DISTRIBUTION IN ACUTE POSTINFECTIOUS GLOMERULONEPHRITIS Augustina Jankauskiene,1 Petras Kaltenis.1,2 1Centre for Pediatrics, Vilnius University Children Hospital, Vilnius, Lithuania; 2Vilnius University, Vilnius, Lithuania

W227 ROLE OF NEPHRITIS-ASSOCIATED PLASMIN RECEPTOR(NAPlr) IN ACUTE POSTSTREPTOCOCCAL GLOMERULONEPHRITIS (APSGN) Nobuyuki Yoshizawa,1 Kazuo Yamakami,1 Masayuki Fujino,1 Takashi Oda,1 Michael Boyle.2 1Department of Public Health, National Defense Medical College, Tokorozawa, Saitama, Japan; 2Department of Biology, Juniata College, Huntingdon, PA, United States

W228 NEPHRITOGENIC ANTIGENS IN POST STREPTOCOCCAL GLOMERULONEPHRITIS: BACK TO BACK TESTING OF SPE B AND GAPDH Stephen Batsford,1 Michael Mihatsch,2 Bernardo Rodriguez-Iturbe,3 Sergio Mezzano.4 1Immunology, Institute of Medical Microbiology, Freiburg, Germany; 2Pathology, University of Basel, Basel, Switzerland; 3Nephrology, Hospital Universitario, Maracaibo, Venezuela; 4Nephrology, University Austral de Chile, Valdivia, Chile

W229 ACUTE POSTSTREPTOCOCCAL GLOMERULONEPHRITIS IN ORENBURG REGION, RUSSIAN FEDERATION Nataliya Bervina, Mikhail Kagan. Nephrology, Orenburg Regional Children’s Hospital, Orenburg, Russian Federation

W230 HISTOFUNCTIONAL STATUS OF KIDNEY IN LEPROSY H.K. Aggarwal,1 P. Sharma,1 T.S. Jaiswal,2 V.K. Jain,1 N. Nand.1 1Dept of Nephrology, Pt. B.D.Sharma, PGIMS, Rohtak, Haryana, India; 2Dept of Pathology, Pt. B.D.Sharma, PGIMS, Rohtak, Haryana, India

W231 HISTOCHEMICAL EVIDENCE FOR A ROLE FOR ALPHA SMOOTH MUSCLE ACTIN, HYALURONIC ACID, OSTEOPONTIN AND CD44 IN CRESCENT FORMATION IN VARIOUS HUMAN GLOMERULONEPHRITIS Hironori Nakamura,1 Kozo Kitazawa,1 Kasumi Sato,1 Mitsugu Akashi,2 Tetsuzo Sugisaki.1 1Department of Nephrology, Showa University School of Medicine, Tokyo, Japan; 2Department of Internal Medicine, Kanto Rosai Hospital, Kawasaki, Japan

386 POSTERS WEDNESDAY, JUNE 12

W232 THE HIGH INCIDENCE OF IRREVERSIBLE RENAL LESIONS AMONGST PATIENTS WITH RAPIDLY PROGRESSIVE RENAL FAILURE IN INDIA Venkatesh Moger,1 Vinay Sakhuja,1 Kusum Joshi,2 Ranjana Minz,3 WEDNESDAY Harbir S. Kohli,1 Kamal Sud,1 Krishan L. Gupta,1 Vivekanand Jha.1 1Nephrology, Postgraduate Medical Institute, Chandigarh, India; 2Histopathology, Postgraduate Medical Institute, Chandigarh, India; 3Immunopathology, Postgraduate Medical Institute, Chandigarh, India

W233 SPECTRUM OF CRESCENTIC GLOMERULONEPHRITIS: A TERTIARY CENTER EXPERIENCE Raj Kumar Sharma, Jitendra Kumar, Raka Kaushal, Sandeep Garg, Amit Gupta, Sanjeev Gulati, Ajay Sharma. Nephrolology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, U.P., India

W234 RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS:CLINICO- PATHOLOGICAL STUDY Visweswar Reddy Pachipala,1 Anuradha,1 Girish Narayen,1 Swarnalatha.2 1Nephrology, Osmania General Hospital, Hyderabad, Andhra Pradesh, India; 2Pathology, Apollo Hospitals, Hyderabad, Andhra Pradesh, India

W235 PREVALENCE OF RENAL ABNORMALITIES AMONG HIV- INFECTED PATIENTS IN A LARGE URBAN HEALTH NETWORK IN SAN FRANCISCO Rudolph Rodriguez, Christopher Quale, Andrew Bindman. Medicine, San Francisco General Hospital, UCSF, San Francisco, CA, United States

387 WEDNESDAY, JUNE 12 POSTERS

VASCULITIDES, SYSTEMIC DISEASES: CLINICAL

W236 PREDICTORS OF RENAL AND PATIENT OUTCOMES IN ATHEROEMBOLIC RENAL DISEASE: A PROSPECTIVE STUDY Francesco Scolari,1 Pietro Ravani,2 Simona Guerini,1 Fabio Malberti,2 Rosario Maiorca.1 1Chair of Nephrology, Univ. of Brescia, Brescia, Italy; 2Unit of Nephrology, Istituti Osp., Cremona, Italy

W237 STEROID TREATMENT OF ATHEROEMBOLIC RENAL DISEASE Marisa Santostefano, Roberto Cocchi, Alba Fabbri, Anna Firrincieli, Alessandra Sturani, Maurizio Fusaroli. Neprhrology Dyalisis, S. Maria delle Croci Hospital, Ravenna, Italy

W238 CORTICOSTEROID TREATMENT IMPROVES SURVIVAL OF PATIENTS WITH CHOLESTEROL EMBOLISM Cristiana Rollino, Roberto Boero, Giulietta Beltrame, Michela Ferro, Giacomo Quattrocchio, Francesco Quarello. Nephrology, Ospedale S. G. Bosco, Turin, Italy

W239 50 PATIENTS TREATED WITH PLASMASEPARATION FOR THROMBOTIC MICROANGIOPATHY (TMA)-CLINICAL COURSE AND OUTCOME Christine E. Kurschat,1 Firuseh Farokhzad,1 Gerd R. Hetzel,1 Markus Hollenbeck,2 Bernd Grabensee.1 1Klin. fuer Nephrologie und Rheumatologie, Heinrich-Heine-Univ., Duesseldorf, Germany; 2Nephrologische Klin., Knappschaftskrankenhaus, Bottrop, Germany

W240 FIVE CASES OF LIGHT AND HEAVY CHAIN DEPOSITION DISEASE BY IMMUNOGLOBULIN G-3 KAPPA - A POSSIBILITY OF IMMUNOGLOBULIN G3 DISEASE - Yuhta Oyama,1 Atsushi Komatsuda,2 Hideki Wakui,2 Hiroshi Ohtani,2 Ken-ichi Sawada,2 Yasushi Nakamoto,3 Hirokazu Imai.4 1Dept of Internal Med., Honma Hosp., Sakata, Yamagata, Japan; 2Third Dept of Internal Med., Akita Univ. School of Med., Akita, Japan; 3Dept of Internal Med., Kichijo-ji Asahi Hosp., Musashino, Tokyo, Japan; 4Dept of Nephrology and Rheumatology, Aichi Med. Univ., Aichi-Gun, Aichi, Japan

W241 LIGHT CHAIN DEPOSITION DISEASE OF THE KIDNEY: MORPHOLOGICAL ASPECTS AND CLINICAL CHARACTERISTICS Marco D’Amico,1 Claudio Pozzi,1 Gabriella Moroni,2 Gian Battista Fogazzi,2 Sonia Pasquali,3 Simona Curioni,4 Franco Ferrario,4 Cristiana Rollino,5 Giacomo Quattrocchio,5 Lucia Del Vecchio,1 Francesco Locatelli.1 1Nephrology, Osp A. Manzoni, Lecco, Italy; 2Nephrology, IRCCS Osp Maggiore, Milano, Italy; 3Nephrology, Osp S. Orsola-Malpighi, Bologna, Italy; 4Nephrology, Osp S. Carlo Borromeo, Milano, Italy; 5Nephrology, Osp S. Giovanni Bosco, Torino, Italy

W242 CLINICAL EFFECTS OF INTENSIVE CHEMOTHERAPY ON THE RENAL MANIFESTATIONS OF PRIMARY AL-SYSTEMIC AMYLOIDOSIS Tomohisa Fushimi,1 Takahisa Gono,1 Masayuki Matsuda,1 Shu- ichi Ikeda,1 Kazuhiko Hora.2 1Third Dept of Med., Shinshu Univ. School of Med., Matsumoto, Nagano, Japan; 2Div. of Artificial Kidney, Shinshu Univ. School of Med., Matsumoto, Nagano, Japan

W243 WHAT IS THE RELATIONSHIP BETWEEN FAMILIAL MEDITERRANEAN FEVER AND VASCULITIDES? Ozlem Erdogan, Gulay Demircin, Ali Delibas, Mehmet Bulbul, Kenan Bek, Ayse Oner. Pediatric Nephrology, Dr.Sami Ulus Children’s Hosp., Ankara, Turkey

388 POSTERS WEDNESDAY, JUNE 12

W244 LATE ADMINISTRATION OF COLCHICINE IN RENAL AMYLOIDOSIS OF FAMILIAL MEDITERRANEAN FEVER (FMF): DOES THE GENOTYPE PREDICT RESPONSE? Ashot Sarkissian,1 Marina Papazyan,1 Ernst Leumann,2 Tamara WEDNESDAY Sarkisian,3 Armen Sanamyan.4 1Nephrology, Arabkir Medical Centre, Yerevan, Armenia; 2Paediatric Nephrology, University Children’s Hospital, Zurich, Switzerland; 3Molecular Genetics, Center for Medical Genetics of Armenian NAS, Yerevan, Armenia; 4Paediatric Pathology, Republican Centre of Anatomic Pathology, Yerevan, Armenia

W245 RISK FACTORS FOR RENAL AMYLOIDOSIS IN FAMILIAL MEDITERRANEAN FEVER (FMF) Ashot Sarkissian,1 Marina Papazyan,1 Tamara Sarkisian,2 Armen Sanamyan,3 Ernst Leumann,4 Ara Babloyan.1 1Nephrology, Arabkir Medical Centre, Yerevan, Armenia; 2Molecular Genetics, Center of Medical Genetics of Armenian NAS, Yerevan, Armenia; 3Paediatric Pathology, Republican Centre of Anatomic Pathology, Yerevan, Armenia; 4Paediatric Nephrology, University Children’s Hospital, Zurich, Switzerland

W246 OXIDATIVE STRESS STATUS IN FAMILIAL MEDITERRANEAN FEVER PATIENTS WITH AND WITHOUT PROTEINURIA Fatih Bulucu,1 Murat Gurbuz,1 Yavuz Baykal,1 Yusuf Oguz,2 Abdulgaffar Vural,2 Ahmet Aydin,3 Ismail Hakki Kocar.1 1Internal Medicine, 2Nephrology, 3Pharmaceutical Sciences, Gulhane Military Medical Academy, Ankara, Turkey

W247 RENAL AMYLOIDOSIS IN PATIENTS WITH MEDITERRANEAN FEVER (FMF) Hayet Kaaroud, Fatma Ben Moussa, Soumaya Beji, Samia Barbouche, Rym Goucha, Sami Turki, Hedi Ben Maiz. Nephrology and Internal Med., Charles Nicolle Hosp., Tunis, Tunisia

W248 EFFECT OF THE COLCHICINE ON WATER METABOLISM IN FAMILIAL MEDITERRANEAN FEVER (FMF) PATIENTS Celalettin Usalan,1 Bulent Akgul,2 Ozlem Tiryaki,2 Seyma Tataroglu,2 Ayten Oguz.2 1Nephrology, Gaziantep University, Gaziantep, Turkey; 2Internal Medicine, Gaziantep University, Gaziantep, Turkey

W249 RAPIDLY PROGRESSIVE RENAL FAILIURE WITH MESANGEAL C3 DEPOSIT IN A PATIENT WITH ACUTE BRUCELLOSIS Mohammad Reza Ardalan,1 Akram Fakhrejo.2 1Nephrology Dept, Imam Khomaini Hosp., Tabriz, Iran; 2Pathology Dept, Imam Khomaini Hosp. Tabriz, Iran

W250 THE ROLE OF HEMODYNAMIC MECHANISMS IN PROGRESSING OF NEPHROPATHY IN PATIENTS WITH RHEUMATOID ARTHRITIS Boris Nemtsov, Galina Postnikova. Internal Medicine Department, Kirov State Medical Academy, Kirov, Kirov Region, Russian Federation

W251 CLINICAL AND MORPHOLOGICAL FEATURES OF KIDNEY INVOLVEMENT IN PRIMARY SJÖGREN’S SYNDROME (SS) Daniela Monova, M. Panchovska, S. Monov, R. Stoilov, R. Rashkov. Dept of Internal Medicine, Medical University - Sofia, Sofia, Bulgaria

W252 SEVERE JUVENILE DERMATOMYOSITIS, COMPLICATED BY HYDRONEPHROSIS DUE TO URETERITIS CALCIFICANS Dimitrina Mihaylova,1 Marusia Lilova,1 Slavcho Chanachev.2 1Clinic of Pediatric Nephrology, Medical University, Sofia, Bulgaria; 2Clinic of Pediatric Urology, Institute for Emergency Healthcare, Sofia, Bulgaria

389 WEDNESDAY, JUNE 12 POSTERS

HYPERTENSION: CLINICAL

W253 CLINICAL PROFILE OF RENOVASCULAR HYPERTENSION AT IKDRC – AHMEDABAD Divyesh Viroja, Pravina Shah, H.L. Trivedi, Veena Shah, Aruna Vaniker. Nephrology, IKDRC, Ahmedabad, Gujarat, India

W254 PREDICTORS OF SIGNIFICANT ATHEROSCLEROTIC RENAL ARTERY STENOSIS IN HYPERTENSIVE PATIENTS Siren Sezer,1 F. Nurhan Ozdemir,1 Erhan Agca,1 Muharrem Taskoparan,2 Cuneyt Aytekin,3 Mehmet Haberal.4 1Dept of Nephrology, Baskent Univ. Faculty of Medicine, Ankara, Turkey; 2Dept of Internal Medicine, Baskent Univ. Faculty of Med., Ankara, Turkey; 3Dept of Radiology, Baskent Univ. Faculty of Med., Ankara, Turkey; 4Dept of General Surgery, Baskent Univ. Faculty of Med., Ankara, Turkey

W255 SHORT TERM EFFECTS OF RENAL ARTERY STENTING ON BLOOD PRESSURE AND RENAL FUNCTION IN RENAL TRANSPLANT RECEPIENTS Munavvar Izhar,1 Dipak Mital,2 Stephen Jensik,2 George Bakris.1 1Department of Preventive Medicine, Rush-Presbyterian-St.-Luke’s- Medical Center, Chicago, IL; 2Department of Transplant Surgery, Rush-Presbyterian-St.-Luke’s-Medical Center, Chicago, IL, USA

W256 AORTIC SPIRAL FLOW RELEVANCE TO RENAL ATHEROSCLEROSIS: MRI AND COMPUTATIONAL FLUID DYNAMICS ANALYIS T. Sudershan,1 Allan Thomson,1 Peter Stonebridge,2 John Dick,3 Graeme Houston.1 1Clinical Radiology, Tayside Univ. Hospitals NHS Trust, Dundee, Scotland, UK; 2Vascular Surgery; 3Vascular Medicine

W257 SIGNIFICANT PROTEINURIA AND EFFECTS OF DIRECT STENTING IN RENAL ARTERY STENOSIS PATIENTS Adalbert Schiller,1 Cristian Dina,1 Gheorghe Gluhovschi,1 Ligia Petrica,1 Gheorghe Bozdog,2 Virginia Trandafirescu,1 Silvia Velciov.1 1Clinic of Nephrology, Univ. of Med. and Pharmacy, Timisoara, Timis, Romania; 2Clinic of Nephrology, County Hosp., Timisoara, Timis, Romania

W258 RENAL ARTERIAL INTERVENTION THEN SUSTAINED USE OF ACEI / ARB IN ARAS CAN BE A SAFE AND EFFECTIVE TREATMENT FOR REFRACTORY ARAS-HYPERTENSION Rajaventhan Srirajaskanthan, Marlies Ostermann, David Goldsmith. Renal Medicine and Transplantation, Guy’s Hospital, London, UK

W259 ANGIOTENSIN CONVERTING ENZYME INHIBITOR(ACEI) OR ANGIOTENSIN II RECEPTOR BLOCKER (ARB) IN PATIENTS WITH RENAL DISEASE WHICH ONE TO CHOSE? Kaligotla Venkata Dakshinamurty, Pillalamarri Neelaprasad, Ram Rapoor, Chirala Sundarakrishna, Taduri Gangadhar, C.T. Sridhar, Velagala Sattireddy, Raju Sreebhushan. Nephrology, Nizams Inst. of Medical Sciences, Hyderabad, Andhrapradesh, India

W260 CT-ANGIOGRAPHY AS A SCREENING TEST FOR RENOVASCULAR HYPERTENSION Ioannis Griveas,1 Dorothea Papadopoulou,1 Vasilios Souftas,2 Eftasthios Mitsopoulos,1 Dimitrios Melidis,2 Parthena Kyriklidou,1 Evdoxia Ginikopoulou,1 Dafni Meimaridou,1 George Visvardis,1 Eleni Manou,1 Rafail Papadopoulos,1 Maria Tsiatsiou,1 Ioannis Tsit 1Nephrology, Papageorgiou General Hospital, Thessaloniki, Greece; 2Radiology, Papageorgiou General Hospital, Thessaloniki, Greece

390 POSTERS WEDNESDAY, JUNE 12

W261 ISCHEMIC NEPHROPATHY:COMPARISON OF RENAL FUNCTION IN PATIENTS WITH RENAL ARTERY STENOSIS DUE TO DIFFERENT ETIOLOGIES Takashi Inenaga, Satoko Nakamura, Fumiki Yoshihara, Hajime WEDNESDAY Nakahama, Yuhei Kawano. Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan

W262 PREECLAMPSIA - RENAL CNANGES ASSESSMENT BY CONVENTIONAL AND DOPPLER ULTRASOUND (US) Mila Lubomirova,1 Regina Djerassi,1 Veselin Djavolov,2 Asen Nikolov,2 Pravda Popivanova,2 Veneta Stojkova,2 Angel Dimitrov.2 1Clinic of Nephrology, University Hospital Alexandrovska, Sofia, Bulgaria; 2Obstetrics and Gynecology, University Hospital of Obstetrics and Gynecology “Majtchin Dom”Sofia, Bulgaria

W263 PARATHYROID HORMONE IN RELATION WITH BLOOD PRESSURE IN NORMAL PREGNANCY AND PREGNANCY INDUCED HYPERTENSION Ljubinka Lozance,1 Katica Zafirovska,1 Stevka Bogdanovska,1 Biljana Gerasimovska-Kitanovska,1 Vesela Malevska,2 Olivija Vaskova.3 1Dept Nephrology, Clin Centre, Skopje, F.Y.R.M.; 2Inst Physiology, Med Faculty, Skopje, F.Y.R.M.; 3Inst of Pathophysiology, Med Faculty, Skopje, F.Y.R.M.

W264 PREECLAMPSIA IS A SYNDROME OF COMPROMISED ALDOSTERONE SYNTHESIS Kushiar Shojaati,1 Maja Causevic,1 Bert Kadereit,1 Bernhard Dick,1 Jeannine Imobersteg,2 Henning Schneider,2 Ernst Beinder,3 Brigitte Frey,1 Felix Frey,1 Markus Mohaupt.1 1Division of Nephrology/Hypertension, University of Berne, Berne, Switzerland; 2Women’s Hospital, University of Berne, Berne, Switzerland; 3Women’s Hospital, University of Zurich, Zurich, Switzerland

391 WEDNESDAY, JUNE 12 POSTERS

HEREDITARY RENAL DISEASES

W265 STABILIZATION OF RENAL FUNCTION AFTER ENZYME REPLACEMENT THERAPY IN FABRY DISEASE Stephen Waldek, Dominique P. Germain, Maryam Banikazemi, Nathalie Guffon, Philip Lee, Gabor Linthorst, William Wilcox, Robert J. Desnick, Barry M. Brenner for the Int’l Collaborative Fabry Disease Study Group.

W266 EVALUATION OF RENAL AND CARDIAC FUNCTION AFTER ENZYME REPLACEMENT THERAPY IN PATIENTS WITH FABRY’S DISEASE AND RENAL INVOLVEMENT Elli Koliousi,1 R. Kalaitzidis,1 D. Patsiouras,1 Marina Rizou,1 E. Andrikos,2 M. Pappas,2 K.P. Katopodis,1 Margarita Ikonomou,1 K.C. Siamopoulos.1 1Dept of Nephrology, University Hospital of Ioannina; 2Dept of Nephrology, General Hospital of Ioannina, Ioannina, Greece

W267 IMPROVED RENAL FUNCTION UNDER AGALSIDASE ALFA TREATMENT IN FABRY PATIENTS Francois Dehout,1 Andreas Schwarting,2 Michael Beck,3 Abelardo Garcia de Lorenzo,4 Ales Linhart,5 Atul Mehta,6 Roberta Ricci,7 Gere Sunder-Plassmann,8 Urs Widmer.9 1Dept of Nephrology, CHU Charleroi, Charleroi, Belgium; 2Dept of Nephrology, Univ. of Mainz, Mainz, Germany; 3Dept of Paediatrics, Univ. of Mainz, Mainz, Germany; 4Formacion Medica Continuada, Hosp. Univ. La Paz, Madrid, Spain; 5Second Dept of Internal Medicine, Charles Univ., Prague, Czech Republic; 6Dept of Haematology, Royal Free Hosp., London, UK; 7Inst. of Clinical Paediatrics, UCSC, Rome, Italy; 8Div. of Nephrology and Dialysis, Univ. of Vienna, Vienna, Austria; 9Dept of Medicine, Univ. Hosp., Zurich, Switzerland

W268 ARTERIAL STIFFNESS IS REDUCED BY ENZYME REPLACEMENT THERAPY FOR FABRY’S DISEASE Vlado Perkovic,1,2 Kathy Nicholls,1 Racheal De Caneva,1 Elizabeth Centra,1 Gavin Becker.1 1Dept of Nephrology, Royal Melbourne Hosp., Melbourne, Victoria, Australia; 2Royal Melbourne Hosp. Dept of Medicine, Univ. of Melbourne, Melbourne, Victoria, Australia

W269 CLINICAL BENEFIT OF ENZYME REPLACEMENT THERAPY IN TWELVE SEVERELY AFFECTED FABRY PATIENTS AFTER ONE YEAR OF TREATMENT Frank Breunig,1 Frank Weidemann,2 Meinrad Beer,3 Jörg Strotmann,2 Jörn Sandstedte,3 Andreas Eggert,4 Christoph Wanner.1 1Dept of Nephrology, Univ. of Wuerzburg, Wuerzburg, Germany; 2Dept of Cardiology, Univ. of Wuerzburg, Wuerzburg, Germany; 3Dept of Radiology, Univ. of Wuerzburg, Wuerzburg, Germany; 4Dept of Dermatology, Univ. of Wuerzburg, Wuerzburg, Germany

W270 NO LOSS OF AGALSIDASE-BETA IN FABRY PATIENTS INFUSED DURING HAEMODIALYSIS Markus Kosch,1 Hans Georg Koch,2 Joao Paulo Oliveira,3 Francesco Bianco,4 Frank Breunig,5 Roland Schaefer.1 1Dept of Internal Med. D, Univ. of Muenster, Muenster, Germany; 2Dept of Paed., Univ. of Muenster, Muenster, Germany; 3Dept of Nephr., Hosp. S. João, Porto, Portugal; 4Dept of Nephr., Osp. di Cattinara, Trieste, Italy; 5Dept of Nephr., Univ. of Wuerzburg, Wuerzburg, Germany

W271 ENZYME REPLACEMENT THERAPY IN FABRY DISEASE: WHAT IS THE BEST MARKER OF RENAL FUNCTION? Sandro Feriozzi,2 Daniela Antuzzi,1 Mariangela Di Lillo,1 Mario Castorina,1 Enzo Ancarani,2 Roberta Ricci.1 1Università Cattolica del Sacro Cuore, Clinica Pediatrica, Roma, Italy; 2Nefrologia e Dialisi, Ospedale Belcolle, Viterbo, Italy

392 POSTERS WEDNESDAY, JUNE 12

W272 STABILISATION OF KIDNEY FUNCTION IN A GROUP OF 15 PATIENTS DIAGNOSED WITH FABRY DISEASE AND TREATED WITH FABRAZYME ® FOR A YEAR Nathalie Guffon. WEDNESDAY Paediatric Department, Hopital Edouard Herriot, Lyon, France

W273 GENETIC EPIDEMIOLOGY OF THE CLASSICAL PHENOTYPE OF FABRY DISEASE IN THE NORTHWEST OF PORTUGAL João Paulo Oliveira,1,2 Susana Ferreira,1 Carlos Soares,2 Susana Fernandes,1 Clara Miranda,3 Idalina Beirão,4 Sven Sørensen,5 Bryan Winchester.6 1Serviço de Genética Médica, Faculdade de Medicina do Porto, Porto, Portugal; 2Serviço de Nefrologia, Hospital São João, Porto, Portugal; 3Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal; 4Serviço de Nefrologia, Hospital Santo António, Porto, Portugal; 5Institute of Medical Genetics, University of Copenhagen, Copenhagen, Denmark; 6Institute of Child Health, University College, London, United Kingdom

W274 ENZYME REPLACEMENT THERAPY WITH AGALSIDASE b IN FABRY’S DISEASE PATIENTS WITH KIDNEY TRANSPLANTATION: RESULTS AFTER 1 YEAR OF TREATMENT Renzo Mignani,1 Vincenzo Panichi,2 Fabrizio Martinelli,3 Antonio Giudicissi,4 Antonio Pisani,5 Rita Barone,6 Gloriano Moneti,7 Daniele Taccola,2 Carlo Poliatti,6 Carlo Feletti,4 Leonardo Cagnoli.1 1Nephrology and Dialysis, Infermi Hosp., Rimini; 2Nephrology and Dialysis, S.Chiara Univ. Hosp., Pisa; 3Nephrology and Dialysis, Careggi Univ. Hosp., Florence; 4Nephrology and Dialysis, Bufalini Hosp., Cesena; 5Nephrology and Dialysis, Federico II Univ. Hosp., Naples; 6Institute of Pediatric, Univ. of Catania, Catania; 7Mass Spectrometry Centre, Florence, Italy

W275 TREATMENT OF THREE FABRY PATIENTS WITH MODERATE RENAL FAILURE AND DESCRIPTION OF THE RENAL VARIANT Roser Torra,1 Carlos Del Pozo,3 Jordi Yague,2 Ballarin Jose,1 Barcelo Pedro.1 1Nephrology, Fundacio Puigvert, Barcelona, Spain; 2Inmunology, Hospital Clínic, Barcelona, Spain; 3Nephrology, Virgen de los Lirios, Alcoy, Alicante, Spain

W276 RATIONAL DIAGNOSTIC APPROACH TO FABRY DISEASE Berghaeuser Ma,1 R.M. Schaefer,2 H.G. Koch.1 1Dept of Pediatrics, University Hospital, Muenster, Germany; 2Dept of Internal Medicine D, University Hospital, Muenster, Germany

W277 CENTRALIZED DATA COLLECTION IN RARE GENETIC DISEASES: THE FABRY REGISTRY C. Wanner,1 J. Bultas,2 U. Feldt-Rasmussen,3 D.P. Germain,4 N. Guffon,5 N. Leech,6 G. Linthorst,7 J.-E. Mansson,8 J.P. Oliveira,9 M. Spada,10 V. Tooregrossa,11 A. Tylki-Szymanska.12 1Dept Nephrologie, Medizinische UniversitätsKlinik, Würzburg, Germany; 2Charles University, Prague, Czech Republic; 3Rigshospitalet, København, Denmark; 4Hôpital Eur Georges Pompidou, Paris, France; 5Hôpital E. Herriot, Lyon, France; 6Royal Victoria Infirmary, Newcastle, United Kingdom; 7Academisch Medisch Centrum, Amsterdam, Netherlands; 8Sahlgren’s University Hospital, Molndal, Sweden; 9Faculdade de Medicina, Porto, Portugal; 10Hospital Malattie Metaboliche, Torino, Italy; 11Hospital Clinic i Provincial, Barcelona, Spain; 12Klinika Chorob Metabolicznych, Warsaw, Poland

W278 A NOVEL APOLIPOPROTEIN E MUTATION IN CHINESE LIPOPROTEIN GLOMERULOPATHY PATIENTS Yuqing Chen, Hong Zhang, Shile Zhu, Wanzhong Zou, Mei Wang, Haiyan Wang. Renal Division, First Hospital of Peking University, Beijing, China

393 WEDNESDAY, JUNE 12 POSTERS

W279 AUTOSOMAL DOMINANT NEPHRITIS IN YEMENITE JEWS - LACK OF LINKAGE TO CANDICATE LOCI Dganit Dinour,1 Rita Kunin,1 Danny Lotan,2 Irina Serban,1 Eliezer Holtzman.1 1Nephrology and Hypertension, Chaim Sheba Medical Center, Tel- Hashomer, Israel; 2Pediatric Nephrology Unit, Chaim Sheba Medical Center, Tel-Hashomer, Israel

W280 A NOVEL MUTATION IN THE ANION EXCHANGER 1 GENE (AE1) ASSOCIATED WITH DISTAL RENAL TUBULAR ACIDOSIS (dRTA) Lara Cheidde,1 Tereza Vieira,2 Paulo Lima,3 Sara Saad,3 Ita Heilberg.1 1Nephrology Div., Univ. Federal de São Paulo, São Paulo, Brazil; 2Endocrinology Div., Univ. Federal de São Paulo, São Paulo, Brazil; 3Hematology Div., Univ. de Campinas, Campinas, São Paulo, Brazil

W281 FAMILIAL PURE PROXIMAL TUBULAR ACIDOSIS - A CLINICAL AND GENETIC STUDY Ze’ev Katzir,1,2 Dganit Dinour,3 Irina Serban,3 Haike Reznik-Wolf,3 Shmuel Smetana,1 Eliezer Holtzman.3 1Nephrology and Hypertension, Wolfson Medical Center, Holon, Israel; 2Pediatric Nephrology Service, Wolfson Medical Center, Holon, Israel; 3Nephrology and Hypertension, Chaim Sheba Medical Center, Tel-Hashomer, Israel

W282 A CLUSTER OF MUTATIONS IN THE UROMODULIN GENE CAUSES FAMILIAL JUVENILE HYPERURICEMIC NEPHROPATHY K. Dahan,1 M. Smaers,1 G. Loute,2 J.M. Poux,3 D. Chauveau,4 C. Antignac,5 Ch. Verellen,1 Y. Pirson.6 1Center for Human Genetics, UCL-St Luc, Brussels, Belgium; 2Dept of Nephrology, Princesse Paola Hospital, Aye, Belgium; 3Dept of Nephrology, Frejus, France; 4Dept of Nephrology, Hop. Necker- Enfants Malades, France; 5INSERM U423, Hop. Necker- Enfants Malades, Paris, France; 6Dept of Nephrology, UCL- St Luc, Brussels, Belgium

W283 TWO MALE SIBLINGS OF HEREDITARY RENAL HYPOURICEMIA WITH EXERCISE-INDUCED ACUTE RENAL FAILURE Motoko Tanaka,1 Kazuko Itoh,1 Kazunori Matsushita,1 Kazutaka Matsushita,1 Naoki Wakita,2 Masataka Adachi,2 Hiroshi Nonoguchi,2 Kenichiro Kitamura,2 Makoto Hosoyamada,3 Hitoshi Endou,3 Kimio Tomita.2 1Dept of Nephrology, Akebono Clinic, Kumamoto, Japan; 2Third Dept of Internal Medicine, Kumamoto Univ School of Medicine, Kumamoto, Japan; 3Dept of Pharmacology and Toxicology, Kyorin Univ School of Medicine, Shinkawa, Mitaka, Japan

W284 NOVEL MUTATIONS OF THE VASOPRESSIN RECEPTOR 2 GENE ASSOCIATED WITH CONGENITAL NEPHROGENIC DIABETES INSIPIDUS Konstantinos Kamperis,1 Charlotte Siggaard,1 Lene Rytter,2 Gary Robertson,3 Soren Rittig.1 1Pediatrics, Skejby Univ. Hosp., Aarhus, Denmark; 2Pediatrics, Randers Hosp., Randers, Denmark; 3Med. Sch., Northwest Univ., Chicago, IL, USA

W285 ABSENCE OF THIAZIDE-SENSITIVE Na-Cl COTRANSPORTER (NCC) IMMUNOSTAINING IN RENAL TISSUES FROM GITELMAN’S SYNDROME Gheun-Ho Kim,1 Kwon Wook Joo,2 Ju-Young Jung,3 Jin Kim,3 Yoon Kyu Oh,4 Un Sil Jeon,5 Mark Knepper,6 Jin Suk Han.2 1Internal Med., Hallym Univ. Hangang Sacred Heart Hosp., Seoul, Republic of Korea; 2Internal Med., Seoul National Univ. College of Med., Seoul, Republic of Korea; 3Anatomy, Catholic Univ. of Korea, Seoul, Republic of Korea; 4Internal Med., Eulji Medical College, Seoul, Republic of Korea; 5Internal Med. Korea Cancer Center Hosp., Seoul, Republic of Korea; 6LKEM, NHLBI/NIH, Bethesda, MD, USA

394 POSTERS WEDNESDAY, JUNE 12

W286 PHENOTYPIC VARIABILITY IN BARTTER SYNDROME TYPEIII Alberto Bettinelli,1 Nicolo’ Borsa,2 Silvana Tedeschi,2 Alberto Edefonti,3 Marisa Giani,3 John Komninos,4 Domenico Coviello.2 1Dept of Pediatrics, S.Leopoldo Mandic Hosp., Merate, Lecco, Italy; WEDNESDAY 2Laboratory of Medical Genetics, Istituti Clinici Perfezionamento, Milan, Italy; 3Dialysis Unit, Istituti Clinici Perfezionamento, Milan, Italy; 4Dept of Endocrinolgy, Evangelismos General Hosp., Athens, Greece

W287 GENETIC ANALYSIS OF NORMOTENSIVE HYPOKALEMIC SALT-LOSING TUBULOPATHIES IN THE ITALIAN POPULATION Silvana Tedeschi,1 Marie-Louise Syrén,2 Nicolo’ Borsa,1 Francesca Sironi,1 Alberto Edefonti,3 Domenico Coviello,1 Alberto Bettinelli.3,4 1Laboratory of Medical Genetics, Istituti Clinici di Perfezionamento, Milan, Italy; 2Dept of Pediatrics and Neonathology, Univ. degli Studi, Milan, Italy; 3Dialysis Unit, Istituti Clinici di Perfezionamento, Milan, Italy; 4Dept of Pediatrics, San Leopoldo Mandic Hosp., Merate, Lecco, Italy

W288 A LARGE DELETION MUTANT OF THIAZIDE-SENSITIVE Na-Cl COTRANSPORTER IN A PATIENT WITH HYPOKALEMIA AND HYPOMAGNESIMIA Minoru Yasujima,1 Shoji Tsutaya,2 Masaru Shoji.1 1Department of Laboratory Medicine, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan; 2Department of Clinical Laboratory, Hirosaki University Hospital, Hirosaki, Aomori, Japan

W289 GENETIC MAPPING OF AUTOSOMAL DOMINANT RENAL FANCONI SYNDROME IN TWO FAMILIES SUPPORTS LINKAGE TO CHROMOSOME 15q15.3 Claire Willoughby,1 Christopher Laing,1,2 Timo Heikkila,1 Nicolas Pineda,1 Andres Ruiz-Linares,1 Anthony Norden,3 Oliver Wrong,1,2 Robert Unwin,1,2 Sue Povey.1 1Renal Genetics Group, Dept Biology, Galton Lab, Univ Coll London, London, UK; 2Centre for Nephrology, Depts Medicine & Physiology, Royal Free & Univ Coll London Med School, London, UK; 3Dept Clinical Biochemistry, Addenbrookes Hospital, Cambridge, UK

W290 QUALITATIVE ABNORMALITIES IN THE PROTEOME OF DENT’S DISEASE URINE Pedro Cutillas,1,2 Anthony Norden,3 Rainer Cramer,1,2 Alma Burlingame,1,2,4 Robert Unwin.5 1Bioanalytical Chemistry, Ludwig Institute for Cancer Research, London, UK; 2Dept of Biochemistry, Univ.College London, London, UK; 3Dept of Clinical Biochemistry, Addenbrooke’s Hospital, Cambridge, UK; 4Dept of Pharmaceutical Chemistry, Univ. of California, San Francisco, CA, USA; 5Centre for Nephrology and Dept of Physiology, Royal Free and Univ. College Medical School, London, UK

W291 MASSIVE GLUCOSURIA DUE TO A DEFECT OF GLUT2 – THE FANCONI-BICKEL SYNDROME Ashot Sarkissian,1 Rene Santer,2 Beat Steinmann,3 Gayane Amaryan,1 Ernst Leumann.4 1Paediatric Nephrology, Arabkir Medical Centre, Yerevan, Armenia; 2Paediatrics, University Children’s Hospital, Kiel, Germany; 3Metabolic and Molecular Diseases, University Children’s Hospital, Zurich, Switzerland; 4Paediatric Nephrology, University Children’s Hospital, Zurich, Switzerland

W292 CLINICAL AND PATHOLOGIC FEATURES OF THE NEPHROPATHY ASSOCIATED WITH AN A TO G MUTATION OF MITOCHONDRIAL DNA AT THE POSITION OF LEUCINE tRNA (MELAS MUTATION) Junichi Hoshino,1 Yoshifumi Ubara,1 Naoki Sawa,1 Masafumi Yokota,1 Tetsuo Tagami,1 Hideyuki Katori,1 Fumi Takemoto,1 Shigeo Hara,2 Shigeko Hara.1 1Kidney Center, Toranomon Hospital, Minato-ku, Tokyo, Japan; 2Dept of Pathology, Toranomon Hospital, Minato-ku, Tokyo, Japan

395 WEDNESDAY, JUNE 12 POSTERS

W293 ARE THERE HISTOLOGICAL FEATURES SUSPECTED OF MITOCHONDRIAL NEPHROPATHY? Yutaka Yamaguchi, Yukiko Kanetsuna, Sachiko Ishii, Mitsuhiro Omura. Department of Pathology, Kashiwa Hospital, Jikei University, Kashiwa-shi, Chiba-ken, Japan

W294 FAMILIAL HYPOMAGNESEMIA WITH HYPERCALCIURIA AND NEPHROCALCINOSIS Jameela Kari, Mohammed Farouq, Hammad Alshaya. Pediatrics, King AbdulAziz University Hospital, Jeddah, Saudi Arabia

W295 INCREASED LEVELS OF PYROGLUTAMIC ACID IN CYSTINOSIS FIBROBLASTS Liliana Mannucci,1 Cristiano Rizzo,2 Carlo Dionisi Vici,2 Gianfranco Rizzoni,1 Francesco Emma.1 1Division of Nephrology, Bambino Gesù Children’s Hospital and Research Institute, Rome, Italy; 2Unit of Metabolic Diseases, Bambino Gesù Children’s Hospital and Research Institute, Rome, Italy

W296 RENAL INVOLVEMENT IN SICKLE CELL ANAEMIA Fatma Ben Moussa, Rym Goucha, Hayet Kaaroud, Hafedh Hedri, Ezzeddine Abderrahim, Hedi Ben Maiz. Nephrology and Internal Medicine, Charles Nicolle Hospital, Tunis, Tunisia

396 POSTERS WEDNESDAY, JUNE 12

CLINICAL NEPHROLOGY: MISCELLANEOUS WEDNESDAY W297 DIAGNOSTIC ACCURACY OF ACANTHOCYTURIA BY PHASE CONTRAST MICROSCOPE IN DIFFERENTIATING THE GLOMERULAR AND NONGLOMERULAR ORIGIN OF HAEMATURIA Effat Razeghi,1 Khadijeh Makhdoomi,2 Mahboob Lessan Pezeshki,1 Mitra Mahdavi Mazdeh,1 Eisa Jahanzad,1 Pedram Ahmadpour,1 Sepideh Seifi,1 Sima Maziar,1 Farokhlagha Ahmadi,1 Mohamadreza Khatami.1 1Nephrology, Tehran University of Medical Sciences, Tehran, Iran; 2Nephrology, Urmia Medical School, Urmia, Iran

W298 PREVALENCE OF ISOLATED HAEMATURIA IS HIGH AMONG ZUNI INDIANS Philip Zager,1 Andrew Narva,2 Vallabh Shah,1 Marina Scavini,3 Christine Stidley,1 Arlene Bobelu.4 1Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, United States; 2Kidney Disease Program, Indian Health Service, Albuquerque, NM, United States; 3Medicine, H San Raffaele Scientific Institute, Milan, Italy; 4Dialysis Clinic, Inc., Albuquerque, NM, United States

W299 CARBONYL STRESS IN VITRO INDUCES DYSMORPHIC RED BLOOD CELL FORMATION SEEN IN GLOMERULAR HAEMATURIA Zoltan Wagner, Peter Degrell, Tibor Vas, Laszlo Wagner, Istvan Mazak, Gergo A. Molnar, Boglarka Laczy, Judit Nagy, Istvan Wittmann. Second Department of Medicine and Nephrological Center, University of Pecs, Pecs, Hungary

W300 TEN-YEAR EVALUATION OF THE CLINICAL EFFICACY OF URINARY RED-BLOOD-CELL SIZE DISTRIBUTION CURVES IN DIAGNOSING HAEMATURIA Masaki Ohya,1 Haruhisa Otani,2 Yasushi Saika,1 Hiroko Hirano,1 Iwao Iteya,1 Yoshinori Tone,2 Kiwao Ishimoto,1 Ryouichi Fujii,1 Masatoshi Mune,2 Susumu Yukawa.2 1Department of Internal Medicine, Fujii Hospital, Kishiwada, Osaka, Japan; 2Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan

W301 DEFINING A NORMAL URINARY PROTEOME MAP OF SMALL MOLECULAR WEIGHT PROTEINS AND POLYPEPTIDES USING SELDI® TECHNOLOGY Chek Mei Bok,1 Eastwood H.C. Leung,2 Stephen I.-H. Hsu.1,3 1Biological Investigation Group, Genome Institute of Singapore, Singapore; 2Proteomics Group, Genome Institute of Singapore, Singapore; 3Faculty of Medicine, National University of Singapore, Singapore

W302 THE SCREENING OF PROTEINURIA: COMPARISON OF 24h PROTEINURIA, PROTEINURIA/CREATININURIA RATIO AND DIPSTICK Giacomo Lanfranco, Massimo Gai, Daria Motta, Manuel Burdese, Elisabetta Mezza, Giorgio Soragna, Francesca Bertinotti, Fabrizio Fop, Bernardino Malfi, Alberto Jeantet, Giorgina B. Piccoli, Giuseppe P. Segoloni. University of Torino, Chair of Nephrology, Torino, Italy

397 WEDNESDAY, JUNE 12 POSTERS

W303 PROTEOMIC PATTERNS IN URINE OF PATIENTS WITH PRIMARY RENAL DISEASE Eva M. Weissinger,1 Stefan Wittke,1 Thorsten Kaiser,1 Danilo Fliser,2 Sebastian Bartel,1 Ronald Krebs,1 Frank Hausadel,1 Meike Hillmann,1 Marion Haubitz,2 Harald Mischak,1,2 Hermann Haller.2 1Mosaiques Diagnostics, Mosaiques Diagnostics & Therapeutics AG, Hannover, Lower Saxony, Germany; 2Department of Nephrology, Medical School of Hannover, Hannover, Germany

W304 TRACE ELEMENT LEVELS IN ADULT PATIENTS WITH PROTEINURIA Giacomo Bovio,1 Giovanni Montagna,1 Valter Piazza,1 Luca Semeraro,1 Siro Segagni,1 Alessandro Salvadeo,1 Claudio Minoia,2 Anna Gatti,2 Anna Ronchi.2 1Division of Nephrology and Hemodialysis, Salvatore Maugeri Foundation, Pavia, Italy; 2Laboratory of Environmental Hygiene and Industrial Toxycology, Salvatore Maugeri Foundation, Pavia, Italy

W305 ASSESSMENT OF THE ACCURACY AND CONSISTENCY OF ROUTINE LABORATORY ASSAYS FOR SERUM CREATININE CONCENTRATIONS COMPARED TO HIGH PERFORMANCE LIQUID CHROMATOGRAPHY Ronald Hogg,1 Lisa Fitzgibbons,1 Keith Hyland.2 1Clinical Research, Medical City Dallas Hospital, Dallas, TX, United States; 2Institute of Metabolic Disease, Dept of Neurochemistry, Baylor University Medical Center, Dallas, TX, United States

W306 A POPULATION STUDY OF GFR EVALUATED BY MEANS OF FOUR DIFFERENT FORMULAE IN PATIENTS WITH DIABETES TYPE 2 Gert A. Verpooten,1,3 Jeroen Vanlauwe,2 Jan Donck,3 Jean-Marie Billiouw,3 Jacky Peeters,3 Nic Veys,3 Jan Monballyu,3 Bernard Georges.4 1Department of Nephrology, University of Antwerp; 2Menarini Company Benelux; 3Nederlandstalige Belgische Vereniging voor Nefrologie; 4Groupement des Néphrologues Francophones de Belgique, Belgium

W307 RENAL FUNCTION ESTIMATES IN THE GENERAL POPULATION AS SAMPLED IN THE THIRD NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY (NHANES III) Francis Dumler. Division of Nephrology, William Beaumont Hospital, Royal Oak, MI, United States

W308 PREDICTION OF GLOMERULAR FILTRATION RATE FROM BODY CELL MASS. COMPARISON WITH OTHER PREDICTION FORMULAS Carlo Donadio, Cristina Consani, Michela Ardini, Annalisa Lucchesi. Internal Medicine - Nephrology, University of Pisa, Pisa, Italy

W309 RELATIONSHIP OF PREGNANCY-ASSOCIATED PLASMA PROTEIN-A TO RENAL FUNCTION AND DIALYSIS MODALITIES Marta Kalousova,1,2 Lenka Fialova,1 Tomas Zima,2 Vladimir Tesar,3 Jirina Soukupova,2 Sylvie Sulkova,4 Magdalena Horejsi,4 Miroslav Merta,3 Erna Jelinkova,3 Petr Sramek,5 Ivan Matous Malbohan.1,2 1Institute od Medical Biochemistry, 1st Faculty of Medicine, Charles Univ., Prague, Czech Republic; 2Institute of Clinical Chemistry, General Univ. Hospital and 1st Faculty of Medicine, Charles Univ., Prague, Czech Republic; 31st Dept of Medicine - Nephrology, General Univ. Hospital and 1st Faculty of Medicine, Charles Univ., Prague, Czech Republic; 4Dept of Medicine Strahov, General Univ. Hospital and 1st Faculty of Medicine, Charles Univ., Prague, Czech Republic; 5Pharmacon Research, Prague, Czech Republic

398 POSTERS WEDNESDAY, JUNE 12

W310 SERUM CYSTATIN-C CONCENTRATION AS A MARKER OF GLOMERULAR FILTARTION RATE George Visvardis,1 Ioannis Griveas,1 Rodi Zilidou,2 Efstathios Mitsopoulos,1 Dorothea Papadopoulou,1 Parthena Kyriklidou,1 WEDNESDAY Eleni Manou,1 Evdoxia Ginikopoulou,1 Dafni Meimaridou,1 Rafail Papadopoulos,1 Katerina Pavlitou,2 George Sakellariou.1 1Neohrology, Papageorgiou General Hospital, Thessaloniki, Greece; 2Immunology, Papageorgiou General Hospital, Thessaloniki, Greece

W311 A VALUE OF CYSTATIN C AS A MARKER OF GLOMERULAR FILTRATION Mirjana Sabljar Matovinovic, Mladen Knotek, Josipa Mazalin, Ingrid Prkacin, Zlata Mestric Flegar, Branka Struzic, Dinko Skegro, Anna Mrzljak. Div. of Nephrology, Dept of Medicine, Univ. Hosp. “Merkur”Zagreb, HR, Croatia

W312 BIOSTABILITY OF CYSTATIN C IN SERUM AND PLASMA SAMPLES Jamal Alwakeel, Ahmed Mitwalli, Chaudry Abdul Rauf, Nauman Tarif, Muhammad N. Janjua, Salahuddin N. Mirza. Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia

W313 CYSTATIN C AND CREATININE AS INDICATORS OF RENAL FUNCTION Carlo Donadio,1 Annalisa Lucchesi,1 Michela Ardini,1 Roberto Giordani.2 1Internal Medicine - Nephrology, University of Pisa, Pisa, Italy; 2Medicina Sperimentale, University of Pisa, Pisa, Italy

W314 VALUE OF SERUM CISTATIN-C IN ASSESSMENT OF NORMAL AND IMPAIRED RENAL FUNCTIONS IN THE ELDERLY Izzet Yavuz, Mujdat Yenicesu, Kayser Caglar, Yusuf Oguz, Abdulgaffar Vural. Nephrology, GATA, Ankara, Turkey

W315 DETERMINATION OF THE PRODUCTION RATE AND NON- RENAL CLEARANCE OF CYSTATIN C AND GFR FROM PLASMA CYSTATIN C MEASUREMENTS IN HUMANS Per Sjostrom,1 Ian Jones,2 Martin Tidman.1 1Medical Dept, University Hospital, Orebro, Sweden; 2Clinical Chemistry Laboratory, University Hospital, Orebro, Sweden

W316 EARLY DETECTION OF ACUTE RENAL BY SERUM CYSTATIN C Stefan Herget-Rosenthal,1 Günter Marggraf,2 Frauke Göring,1 Thomas Philipp,1 Andreas Kribben.1 1Dept. of Nephrology, 2Dept. of Thoracic and Cardiovascular Surgery, University of Essen, Essen, Germany

W317 GLOMERULAR FILTRATION RATE ESTIMATION IN PATIENTS WITH ADVANCED CHRONIC RENAL INSUFFICIENCY BASED ON SERUM CYSTATIN C LEVELS Otto Schuck,1 Vladimir Teplan,1 Antonin Jabor,2 Milena Stollova,1 Jelena Skibova.3 1Dept of Nephrology, Transplant Center, Inst. for Clinical and Experimental Medicine, Prague, Czech Republic; 2Dept of Clinical Biochemistry and Hematology, Hosp. Kladno, Kladno, Czech Republic; 3Statistical Dept, Inst. for Clinical and Experimental Medicine, Prague, Czech Republic

W318 IS CYSTATIN C MORE SENSITIVE THAN CREATININE OR CREATININE CLEARENCE FOR MEASURING GFR IN DIFFERENT PATIENT GROUPS? Zerrin Bicik,1 Sevsen Kulaksizoglu,2 Ozlem Yavuz,3 Musa Bali.4 1Nephrology, AIBU Medical Fac., Düzce, Turkey; 2Biochemistry, Gazi Univ. Medical Fac., Ankara, Turkey; 3Biochemistry, AIBU Medical Fac., Düzce, Turkey; 4Nephrology, Gazi Univ. Medical Fac., Ankara, Turkey

399 WEDNESDAY, JUNE 12 POSTERS

W319 SERUM CYSTATIN C IN THE ELDERLY: ASSOCIATIONS WITH HEALTH STATUS Elise Wasén,1 Raimo Isoaho,1 Kari Mattila,2 Tero Vahlberg,3 Sirkka- Liisa Kivelä,1 Kerttu Irjala.4 1Clinical Medicine/General Practice, University of Turku, Turku, Finland; 2Central Laboratory, Turku University Central Hospital, Turku, Finland; 3Department of Biostatistics, University of Turku, Turku, Finland; 4Department of Clinical Chemistry, University of Turku, Turku, Finland

W320 SERUM BETA-TRACE PROTEIN AS A MARKER OF GLOMERULAR FILTRATION RATE IMPAIRMENT. COMPARISON WITH CREATININE, CYSTATIN C AND BETA2- MICROGLOBULIN Carlo Donadio,1 Annalisa Lucchesi,1 Michela Ardini,1 Roberto Giordani.2 1Internal Medicine - Nephrology, University of Pisa, Pisa, PI, Italy; 2Medicina Sperimentale, University of Pisa, Pisa, PI, Italy

W321 IOHEXOL CLEARANCE FOR DETERMINATION OF GLOMERULAR FILTRATION RATE (GFR), USING CAPILLARY ELECTROPHORESIS (CE) Marcelo de Souza Silva, Silva Regina Moreira, Sonia Kiyomi Nishida, Aparecido Bernardo Pereira. Medicine, Nephrology Division, UNIFESP, Sao Paulo, Brazil

W322 CORRELATION OF ULTRASONOGRAPHIC RENAL LENGTH WITH ANTHROPOMETRIC PARAMETERS Anuradha Raman, Manisha Sahay, Girish Narayen. Department of Nephrology, Osmania General Hospital, Hyderabad, Andhra Pradesh, India

W323 RENAL OXIDATIVE METABOLISM MEASUREMENT BY POSITRON EMISSION TOMOGRAPHY WITH 11C ACETATE Laurent Juillard,1 Paul Barthez,2 Marc Janier,3 Frederic Bonnefoi,3 Maurice Laville.1 1Nephrology, HCL, Lyon, France; 2Radiology, National Veterinary School of Lyon, Marcy l’Etoile, France; 3CERMEP, HCL, Lyon, France

W324 MEASUREMENT OF RENAL CORTICAL PERFUSION IN PATIENTS WITH RENOVASCULAR DISEASE USING MRI Thiru A.P. Sudarshan,1 Stephen J. Gandy,1,2 Kris Armoogum,1 Lynsay C. Allan,1 Declan G. Sheppard,1 J. Graeme Houston.1 1Department of Clinical Radiology, Tayside University Hospitals NHS Trust, Ninewells Hospital, Dundee, United Kingdom; 2Medical Physics Department, Tayside University Hospitals NHS Trust, Ninewells Hospital, Dundee, United Kingdom

W325 EVALUATION OF Tc-99m p-AMINOHIPPURIC ACID AS A NEW RENAL AGENT Emilija Jaksic,1 Slobodanka Beatovic,1 Ruben Han,1 Divna Djokic,2 Drina Jankovic,2 Tatjana Maksin.2 1Institute for Nuclear Medicine, Clinical Center of Serbia, Belgrade, Serbia, Yugoslavia; 2Vinca Institute of Nuclear Sciences, Belgrade, Serbia, Yugoslavia

W326 ASSESSMENT OF KIDNEY LENGTH AND VOLUME USING MRI IN PATIENTS WITH SUSPECTED RENOVASCULAR DISEASE Stephen J. Gandy,1,2 Robert M. Blackley,2 Kris Armoogum,2 Thiru A.P. Sudarshan,2 Declan G. Sheppard,2 J. Graeme Houston.2 1Medical Physics Department, Tayside University Hospitals NHS Trust, Ninewells Hospital, Dundee, United Kingdom; 2Department of Clinical Radiology, Tayside University Hospitals NHS Trust, Ninewells Hospital, Dundee, United Kingdom

400 POSTERS WEDNESDAY, JUNE 12

W327 RENAL BIOPSY VIA LAPAROSCOPIC APPROACH Claudio Koren,2 Miguel Simon,1 Jaime Perez Loredo,1 Alberto Villaronga,2 Emilio Longo,2 Javier Walter,1 Ricardo Duilio Martinez.1 WEDNESDAY 1Nephrology, Hospital Churruca, Buenos Aires, Argentina; 2Urology, Hospital Churruca, Buenos Aires, Argentina

W328 COLD STORAGE OF RENAL TISSUE ALTERS DIFFERENTIAL EXPRESSION OF PROTEINS AND PATTERN OF IMMUNOHISTOCHEMICAL STAINING Lea Novak, Heath McCorkle, Landon Wilson, Scott Isbell, Marion Kirk, Craig Rowell, Stephen Barnes, Helen Kim, Coral Lamartiniere, John Thompson, Jiri Mestecky, Jan Novak, Bruce Julian. Surgery, Pharmacology and Toxicology,Microbiology, and Medicine, University of Alabama at Birmingham, Birmingham, AL, United States

W329 RENAL BIOPSY: ANALYSIS OF AN EXPERIENCE OF OVER 30 YEARS Paola Mesiano,1 Luca Besso,1 Marita Marengo,1 Caterina Canavese,1 Giovannino Ciccone,2 Loredana Colla,1 Cristina Marcuccio,1 Piero Stratta.1 1Chair of Nephrology, University of Turin, Turin, Italy; 2Epidemiology Unit of Cancer, University of Turin, Turin, Italy

W330 PREDICTORS OF BLEEDING COMPLICANCES IN PERCUTANEOUS ULTRASOUND GUIDED RENAL BIOPSY Carlo Manno,1 Loredana Arnesano,1 Giovanni F.M. Strippoli,1,2 Nicla Campobasso,1 Loreto Gesualdo,3 Francesco P. Schena.1 1Dept. of Emergency and Organ Transplantation, University of Bari, Bari, BA, Italy; 2Centre for Kidney Research, Cochrane Renal Group, The Children’s Hospital at Westmead, Westmead, NSW, Australia; 3Division of Nephrology, University of Foggia, Foggia, FG, Italy

W331 ISOLATED MICROHAEMATURIA IN CHILDREN: VALUE OF RENAL BIOPSY Danica Batinic,1 Mira Scukanec-Spoljar,2 Danko Milosevic,1 Ljiljana Nizic,1 Kristina Vrljicak,1 Maja Matkovic,1 Danko Batinic,1 Lana Grkovic.1 1Department of Pediatric Nephrologz, Medical Facultz, Yagreb, Croatia; 2Department of Patologz, Medical Facultz, Yagreb, Croatia

401 WEDNESDAY, JUNE 12 POSTERS

ACUTE RENAL FAILURE, TOXIC NEPHROPATHY

W332 CHANGING CAUSES AND PROGNOSIS IN NONTRAUMATIC ACUTE RENAL FAILURE REQUIRING DIALYSIS TREATMENT COMPARING THE YEARS 1981-1990 AND 1991-2000 Georg Biesenbach, Bernhard Schmekal. 2nd Department of Medicine, General Hospital, Linz, Austria

W333 ACUTE RENAL FAILURE IN THE TROPICS: EMERGING TRENDS FROM A TERTIARY CARE HOSPITAL IN SOUTH INDIA Urmila Anandh, S. Renuka, Lloyd Vincent. Nephrology, St. John’s Medical College Hospital, Bangalore, Karnataka, India

ACUTE RENAL FAILURE IN ROMANIA: NEW PATTERNS W334 POINTING A CHANGING SOCIETY Dan-Stefan Vladutiu, Mirela Gherman, Costel Spanu, Ioan-Mihai Patiu, Simona Racasan, Liliana Parvu. Nephrological Clinic, Medical University, Cluj-Napoca, Cluj, Romania

W335 ACUTE RENAL FAILURE (ARF) IN THE ELDERLY Cedomir Cuckovic, Nada Dimkovic. Center for Renal Diseases, Zvezdara University Hospital, Belgrade, Serbia, Yugoslavia

W336 ACUTE RENAL FAILURE (ARF) AT DEPARTMENT OF INTERNAL MEDICINE HASAN SADIKIN GENERAL HOSPITAL: EPIDEMIOLOGICAL DATA Ria Bandiara, Enday Sukandar. Internal Medicine, Division of Nephrology & Hypertension, Padjadjaran School of Medicine, Hasan Sadikin General Hospital, Bandung, West Java, Indonesia

W337 EPIDEMIOLOGY OF ACUTE RENAL FAILURE IN AN ELDERLY POPULATION IN TERUEL (SPAIN) Luis Miguel Lou,1 Beatriz Boned,2 Ana Cruz,3 José Antonio Gimeno,4 Ricardo Gómez.1 1Nephrology, Alcañiz Hospital, Alcañiz, Teruel, Spain; 2Clinical Biochemistry, Alcañiz Hospital, Alcañiz, Teruel, Spain; 3General Medicine, Alcañiz Health Center, Alcañiz, Teruel, Spain; 4Internal Medicine, Alcañiz Hospital, Alcañiz, Teruel, Spain

W338 DIALYSIS DEPENDENT ACUTE RENAL FAILURE ON INTENSIVE CARE UNIT - PROGNOSIS AFTER SURGERY AND IN PATIENTS WITH MEDICAL REASONS Thomas Rath, Martina Gradinger, Bernd Weber, Ulla Albert, Franz- Werner Albert. Department of Nephrology and Transplantation Medicine, Klinikum-Kaiserslautern, Kaiserslautern, Germany

W339 AGE AS A ONE OF THE SIX RISK FACTORS IN THE NEW PREDICTIVE SCORE FOR OUTCOME IN PATIENTS WITH ACUTE RENAL FAILURE Liljana Tozija, Olivera Stojceva-Taneva, Zvezdana Antova, Koco Cakalaroski. Department of Nephrology, Medical Faculty, Skopje, Macedonia, The Former Yugoslav Republic of Macedonia

W340 CLINICAL-PATHOLOGICAL FEATURES OF DIFFERENT DRUG- ASSOCIATED ACUTE TUBULOINTERSTITIAL NEPHRITIS Xiaomei Li, Jinrong Ma, Siqin Bao, Li Yang, Haiyan Wang. Renal Division, Department of Medicine, First Hospital and Institute of Nephrology, Peiking Universtity, Beijing, China PREDICTION OF OUTCOME IN PATIENTS WITH SEPSIS

402 POSTERS WEDNESDAY, JUNE 12

W341 Wim Van Biesen,1 Itir Yegenaga,2 Raymond Vanholder,1 Francis Colardyn,3 Norbert Lameire.1 1Renal Division, University Hospital Ghent, Ghent, Belgium; 2Department of Nephrology, Kocaeli University Medical School, WEDNESDAY Izmit, Turkey; 3Intensive Care Department, University Hospital Ghent, Ghent, Belgium

W342 ACUTE RENAL FAILURE AND PROGNOSIS. A PROSPECTIVE OBSERVATIONAL STUDY Javier Lavilla,1 Astrid Hernandez,1 Juaquin Manrique,1 Esther Rossich,1 Dolores Pujante,1 Nuria Garcia-Fernandez,1 Pedro Errasti,1 Andres Purroy,1 Jokin De Irala.2 1Nephrology, Clinica Universitaria Navarra, Pamplona, Navarra, Spain; 2Epidemiology, Facultad de Medicina, Pamplona, Navarra, Spain

W343 ACUTE RENAL FAILURE (ARF) TREATED WITH HAEMODIALYSIS (HD) IN INTENSIVE CARE UNIT (ICU): RETROSPECTIVE MONOCENTRIC STUDY Antonio Santoro,1 Elena Mancini,1 Graziella Marvasi,2 Chiara Zanzani,2 Rossella Gaggi,1 Cristina Canova,1 Stefano Faenza.2 1Malpighi-Nephrology and Dialysis, Policlinico S:Orsola-Malpighi, Bologna, Italy; 2Institute of Anesthesiology and Intensivce Care Medicine, Policlinico S.Orsola-Malpighi, Bologna, Italy

W344 THE INCIDENCE AND 90 DAY OUTCOME OF ACUTE RENAL FAILURE REQUIRING RENAL REPLACEMENT THERAPY IN SCOTLAND Jyoti Baharani,1 Wendy Metcalfe,3 Heather Martin,1 Lawson Loraine,1 W. Cairns Smith,3 Keith Simpson,2 Alison MacLeod,1 Izhar Khan.1 1Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom; 2Public Health Medicine, University of Aberdeen, Aberdeen, United Kingdom; 3Scottish Renal Registry, Glasgow, United Kingdom

W345 EPIDEMIOLOGY, RISK FACTORS AND OUTCOME OF HOSPITAL- ACQUIRED RENAL FAILURE Pascal Meier,1 Daniel Teta,1 Georges Halabi,1 Frederic Barbey,1 Jean-Blaise Wasserfallen,2 Michel Burnier.1 1Division of Nephrology, CHUV; 2Department of Medicine, CHUV, Lausanne, Switzerland

W346 SURVIVAL RATES IN PATIENTS WITH ACUTE RENAL FAILURE: SINGLE CENTER 15 YEARS RESULTS Milan Radovic,1 Mina Tomovic,2 Sanja Simic-Ogrizovic,1 Vladimir Ostric,1 Visnja Lezaic,1 Ljubica Djukanovic.1 1Clinic of Nephrology, Clinical Center of Serbia, Belgrade, Serbia, Yugoslavia; 2Institute of Anesthesiology, Clinical Center of Serbia, Belgrade, Serbia, Yugoslavia

W347 PREDICTORS OF MORTALITY IN ELDERLY PATIENTS WITH ACUTE RENAL FAILURE H.S. Kohli, A. Bhat, K. Sud, V. Jha, K.L. Gupta, V. Sakhuja. Department of Nephrology, PGIMER, Chandigarh, UT, India

W348 DETERMINANTS OF ACUTE RENAL FAILURE (ARF) POST CARDIOTHORACIC SURGERY (CTS): A PILOT STUDY UTILIZING THE NEW YORK STATE CARDIAC SURGERY REPORTING SYSTEM (CSRS) Jorge Cerda,1 David S. Strogatz,2 Javid Saifi,3 Jayne Prendergast.1 1Dept. of Nephrology, St. Peters Hospital, Albany, NY, United States; 2School of Public Health, SUNY- Albany, Albany, NY, United States; 3Albany Cardiothoracic Surgeons, Albany, NY, United States

403 WEDNESDAY, JUNE 12 POSTERS

W349 PREDICTION OF ARF IN PATIENTS WITH SEPSIS ON THE ICU Itir Yegenaga,1 Wim Van Biesen,2 Raymond Vanholder,2 Francis Colardyn,3 Norbert Lameire.3 1Dept of Nephrology, Kocaeli Univ. Medical School, Izmit, Turkey; 2Renal Div., 3Intensive Care Dept, Univ. Hosp. Ghent, Ghent, Belgium

W350 RISK FACTORS OF RENAL IMPAIRMENT IN PATIENTS UNDERGOING CARDIOPULMONARY BYPASS GRAFT SURGERY Asli Donmez,1 Cigdem Erkaya,1 Zubeyde Arat,2 Atilla Sezgin,3 F. Nurhan Ozdemir.2 1Dept of Anesthesiology, Baskent Univ.Faculty of Med., Ankara; 2Dept of Nephrology, Baskent Univ. Faculty of Med., Ankara; 3Dept of Cardiovascular Surgery, Baskent Univ.Faculty of Med., Ankara

W351 ACUTE RENAL FAILURE AND MORTALITY IN AN INTENSIVE CARE UNIT: USEFULNESS OF A RECENT SEVERITY INDEX SCORE OF THE PROGNOSIS Piero Dionisio,1 Barbara Agostini,1 Nadia Chiappini,1 Elisa Caramello,1 Roberto Bergia,1 Michelangelo Valenti,1 Mauro-Ilario Berto,1 Raffaella Cravero,1 Enrico Schillaci,1 Alessandro Albani,2 Ermanno Spagarino.2 1Dept of Nephrology and Dialysis, Ospedale degli Infermi, Biella, Italy; 2Dept of Intensive Care, Ospedale degli Infermi, Biella, Italy

W352 RENAL DOPPLER IN EVALUATION OF ACUTE RENAL FAILURE (ARF) - A PROSPECTIVE STUDY Balasubramaniam Jeyaraj, Shanthi Balasubramaniam, Palaniappan Nainar. Nephrology, Kidney Care Centre, Tirunelveli, Tamilnadu, India

W353 PLASMA LEPTIN CONCENTRATION IS NOT INCREASED IN PATIENTS WITH NONINFLAMMATORY ACUTE RENAL FAILURE Rafal Ficek, Franciszek Kokot, Jerzy Chudek, Marcin Adamczak, Joanna Ficek, Andrzej Wiecek. Dept of Nephr., Endocrinology and Metabolic Dis., Silesian Univ. Medical School, Katowice, Poland

W354 PRE-OPERATIVE MICROALBUMINURIA IS AN INDEPENDENT PREDICTOR FOR ACUTE RENAL FAILURE FOLLOWING CORONARY ARTERY BYPASS GRAFT Haidong Luo,1 Sylvia Ramirez,1,2 Reida El Oakley,1 Stephen Hsu.1,2 1Faculty of Med., National Univ.of Singapore, Singapore; 2Center for Prevention and Research, National Kidney Found. Singapore, Singapore

W355 THE EFFECT OF PRE-PROCEDURAL CAPTOPRIL ON CONTRAST- INDUCED NEPHROPATHY IN PATIENTS WHO UNDERWENT CORONARY ANGIOGRAPHY Omer Toprak, Mustafa Cirit, Serdar Bayata. 1Internal Medicine, Ataturk Research and Training Hosp., Izmir, Turkey; 2Nephrology, Ataturk Research and Training Hosp., Izmir, Turkey; 3Cardiology, Ataturk Research and Training Hosp., Izmir, Turkey

W356 LESSONS LEARNED FROM THE CATASTROPHIC MARMARA EARTHQUAKE: FACTORS INFLUENCING THE FINAL OUTCOME OF RENAL VICTIMS Mehmet Sukru Sever,1 Ekrem Erek,2 Raymond Vanholder,3 Mehmet Koc,4 Mahmut Yavuz,5 Nilgun Aysuna,1 Hulya Ergin,6 Rezzan Ataman,2 Mujdat Yenicesu,7 Basol Canbakan,8 Celalettin Demircan,9 Norbert Lameire.3 1Nephr., Istanbul School of Med., Istanbul, Turkey; 2Nephr., Cerrahpasa School of Med., Istanbul, Turkey; 3Nephr., Univ. Hosp., Ghent, Belgium; 4Nephr., Marmara School of Med., Istanbul, Turkey; 5Nephr., Uludag School of Med., Bursa, Turkey; 6Nephr., Goztepe Social Security Hosp., Istanbul, Turkey; 7Nephr., Gulhane Military Hosp., Ankara, Turkey; 8Nephr., Numune Hosp., Ankara, Turkey; 9Nephr., Bursa State Hosp., Bursa, Turkey

404 POSTERS WEDNESDAY, JUNE 12

W357 MANAGEMENT OF CRUSH SYNDROME FOLLOWING GUJARAT EARTHQUAKE – JAN.2001 Divyesh Viroja, Pravina Shah, H.L. Trivedi, Vina Shah, Aruna Vaniker. Nephrology, IKDRC, Ahmedabad, Gujarat, India WEDNESDAY

W358 INFLUENCE OF GENDER ON VARIOUS PARAMETERS IN THE CRUSH SYNDROME VICTIMS OF THE CATASTROPHIC MARMARA EARTHQUAKE Mehmet Sukru Sever,1 Raymond Vanholder,2 Ekrem Erek,3 Norbert Lameire.1 1Nephrology, Istanbul School of Med., Istanbul, Turkey; 2Nephrology, University Hospital, Ghent, Belgium; 3Nephrology, Cerrahpasa School of Med., Istanbul, Turkey

W359 NON-TRAUMATIC RHABDOMYOLYSIS AND THE ROLE OF MYOGLOBINEMIA IN ACUTE RENAL FAILURE IN PATIENTS OF SURGICAL PROFILES Natalia Teplova. Anesthesiology Department, Kirov State Medical Academy, Kirov, Kirov Region, Russian Federation

W360 RHABDOMYOLYSIS: INCIDENCE, ETIOLOGY, RENAL INVOLVEMENT AND TREATMENT OPTIONS IN A PROSPECTIVE STUDY Giacomo Quattrocchio,1 Massimo Comune,2 Cristiana Rollino,1 Roberto Boero,1 Giulietta Beltrame,1 Michela Ferro,1 Francesco Quarello.1 1Nephrology, Ospedale S.G.Bosco, Turin, Italy; 2Critical Care Medicine, Ospedale S.G.Bosco, Turin, Italy

W361 ACUTE RENAL FAILURE DUE TO SEVERE CHOLESTASIS IN A BODYBUILDER ABUSING THE ANABOLIC STEROID STANOZOLOL Jochen Wilpert,1 Marcel Geyer,1 Sven Teschner,1 Dawit Assefa,2 Herrmann Pavenstädt,1 Johannes Donauer.1 1Renal Division, Internal Medicine, University Hospital Freiburg, Freiburg, Germany; 2Cardiology Division, Internal Medicine, University Hospital Freiburg, Freiburg, Germany

W362 CLINICAL CHARACTERISTICS OF PATIENTS DEVELOPING ACUTE RENAL FAILURE DUE TO SEPSIS/ SIRS: RESULTS OF A PROSPECTIVE STUDY Itir Yegenaga,1 Eric Hoste,2 Raymond Vanholder,3 Wim Van Biesen,3 Dominique Benoit,2 Gulcin Kantarci,4 Francis Verbeke,3 Ann Mieke Dhont,3 Francis Colardyn,2 Norbert Lameire.2 1Nephrology,Internal Medicine, Kocaeli University,Medical School, Izmit, Derince, Turkey; 2Intensive Care, University Hospital, Gent, Belgium; 3Internal Medicine,Nephrology Division, University Hospital, Gent, Belgium; 4Nephrology, Marmara University, Istanbul, Turkey

W363 A PROSPECTIVE ANALYSIS OF HAEMOSTASIS IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS) WITH ACUTE RENAL FAILURE Jolanta Malyszko,1 Slawomir Czaban,2 Jacek Malyszko,1 Jacek Krajewski,2 Andrzej Siemiatkowski,2 Michal Mysliwiec.1 1Nephrology and Internal Medicine, Medical University, Bialystok, Podlaskie, Poland; 2Intensive Care Unit, Medical University, Bialystok, Podlaskie, Poland

W364 ACUTE RENAL FAILURE IN PATIENTS WITH FALCIPARUM MALARIA: AN AUDIT FROM A TERTIARY CARE HOSPITAL IN THE TROPICS Urmila Anandh. Nephrology, St.John’s Medical College Hospital, Bangalore, Karnataka, India

405 WEDNESDAY, JUNE 12 POSTERS

W365 A PROSPECTIVE STUDY OF PROGNOSTIC FACTORS IN FALCIPARUM MALARIA WITH MULTI ORGAN DYSFUNCTION SYNDROME MANAGED IN INTENSIVE CARE UNIT Tarun Kumar Saha, Manoj Rai, Gopal Kanwar, Pawan Agarwal, Kanta Chatterjee. Nephrology, Apollo Hospitals, Bilaspur, Chattisgarh, India

W366 RENAL INVOLVEMENT IN DENGUE FEVER - A STUDY FROM SOUTH TAMILNADU Balasubramaniam Jeyaraj, Palaniappan Nainar. Nephrology, Kidney Care Centre, Tirunelveli, Tamilnadu, India

W367 THE CLINICAL PROFILE AND PREDICTORS OF MORTALITY OF WEIL’S SYNDROME SEEN AT A REFERRAL CENTRE IN KERALA Ranjit Narayanan, Jyotish C. Gopinathan, Rajaratnam Krishnan, Ramdas Pisharody. Dept of Nephrology, Calicut Med. College, Kozhikode, Kerala, India

W368 BOVINE AORTIC ENDOTHELIAL CELLS ARE SUSCEPTIBLE TO HANTAVIRUS INFECTION: A NEW PERSPECTIVE IN ECOLOGY OF VIRUS HOST INTERACTION Martin Zeier,1 Walter Muranyi,2 Roland Kehm,2 Udo Bahr,2 Muller Sandra,2 Handermann Michaela,2 Darai Gholamreza.2 1Med./Nephr., 2Virology, Univ. of Heidelberg, Heidelberg, Germany

W369 ACUTE RENAL FAILURE DUE TO BEE STINGS Enrique Klahr,1 John Serna.2 1Centro de Terapia Renal de Medellin, RTS, Medellin, Antioquia, Colombia; 2Nefrosalud, RTS, Armenia, Quindio, Colombia

W370 HIGH AND LOW OSMOLALITY, AND NONIONIC RADIOCONTRASTS INHIBIT NITRIC OXIDE IN CULTURED RENAL ARTERY SMOOTH MUSCLE CELLS Luciane Ribeiro,1 Fábio de Assunção e Silva,1 Giovana S. Di Marco,1 Nestor Schor,1 Elisa Mieko Suemitsu Higa.1,2 1Nephrology Division, UNIFESP-Escola Paulista de Medicina, São Paulo, SP, Brazil; 2Emergency Division, UNIFESP-Escola Paulista de Medicina, São Paulo, SP, Brazil

W371 CONTRAST ASSOCIATED NEPHRO TOXICITY Shaista Hussaini, Somasekhar , Krishnan. Nephrology, Apollo Hospital, Hyderabad, Andhra Pradesh, India

W372 ROLE OF N-ACETYL CYSTEINE IN PREVENTION OF CONTRAST NEPHROPATHY IN PATIENTS OF DIABETIC RENAL FAILURE: A PROSPECTIVE STUDY Deepak Shankar Ray,1 V. Srinivas.2 1Department of Nephrology, Seven Hills Hospital, Visakhapatnam, Andhra Pradesh, India; 2Department of Nephrology, Care Hospital, Visakhapatnam, Andhra Pradesh, India

W373 THE INFLUENCE OF GADOPENTETATE DIMEGLUMINE ON THE RENAL FUNCTION IN PATIENTS WITH NORMAL AND REDUCED RENAL FUNCTION Ute Hoffmann,1 Alexandra Reil,1 Johann Link,2 Michael Fischereder,1 Bernhard K. Krämer.1 1Klin. und Poliklin. f. Inn. Medizin II, Univ. of Regensburg, Regensburg, Germany; 2Inst.für Röntgendiagnostik, Univ. of Regensburg, Regensburg, Germany

W374 ACETYLCYSTEINE INDUCES A SIGNIFICANT INCREASE IN GFR IN PATIENTS WITH NORMAL RENAL FUNCTION Ute Hoffmann,1 Bernd Krüger,1 Wolfgang Drobnik,2 Michael Fischereder,1 Bernhard K. Krämer.1 1Klin. und Poliklin.f. Inn. Medizin II, Univ.of Regensburg, Regensburg, Germany; 2Inst.fur Klinische Chemie, Univ. of Regensburg, Regensburg, Germany

406 POSTERS WEDNESDAY, JUNE 12

W375 PREECLAMPSIA AND ACUTE RENAL FAILURE IN WOMEN DURING PREGNANCY (NORTH OF IRAN) Seddigheh Esmaelzadeh, Hadi Sorkhi, Nastaran Jalai. Nephrology, Amirkola Hospital, Babol, Mazandaran, Iran WEDNESDAY

W376 ACUTE RENAL FAILURE IN PREGNANCY: TWENTY YEARS JOURNEY Jai Prakash, Hemant Kumar, Bibekananda Kar, Anil Kumar Singh, Dhananjay Kumar Sinha, Laxmikant Pandey, Prashant G. Kedalaya, Shivendra Singh, Usha . Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

W377 ACUTE LIVER DISEASE AND DIALYSIS DEPENDENT RENAL FAILURE (ARF) FOLLOWING INGESTION OF RAW FISH GALL BLADDER Saubhik Sural, Chandra Sekhar Panja, Ajay Kumar Sarkar. Nephrology, Peerless Hospital and B.K.Roy Research Centre, Calcutta, West Bengal, India

W378 RENAL DYSFUNCTION EARLY IN THE COURSE OF HAEMATOPOIETIC CELL TRANSPLANTATION Yasar Caliskan, Sevgi Kalayoglu-Besisik, Gursel Acarturk, Deniz Sargin, Tevfik Ecder. Department of Internal Medicine, Istanbul School of Medicine, Istanbul, Turkey

W379 CONTINUOUS HAEMOFILTRATION VERSUS CONTINUOUS HEMODIAFILTRATION IN CRITICALLY ILL PATIENTS WITH ACUTE RENAL FAILURE Patrick Saudan,1 Michel Niederberger,2 Michael Zellweger,1 Jerome Pugin,3 Jacques Romand,2 Thomas Perneger,4 Pierre-Yves Martin.1 1Nephrology Unit, 2Surgical Intensive Care Unit, 3Medical Intensive Care Unit, 4Quality of Care Unit, Geneva University Hospitals, Geneva, Switzerland

W380 CONTINUOUS HAEMODIALYSIS IMPROVES THE MORTALITY OF CRITICAL PATIENTS WITH ACUTE RENAL FAILURE IN COMPARISON WITH CONTINUOUS HAEMOFILTRATION Tatsuo Fukushima,1 Yoshisuke Haruna,1 Jun-ichi Ono,2 Takehiko Tokura,1 Tamaki Sasaki,1 Naoki Kashihara.1 1Nephrology, Kawasaki Medical School, Kurashiki, Okayama, Japan; 2Kidney Center, Kawasaki Medical School, Kurashiki, Okayama, Japan

W381 SLOW LOW-EFFICIENT DAILY DIALYSIS (SLED) AS RENAL REPLACEMENT THERAPY FOR ACUTE RENAL FAILURE IN THE INTENSIVE CARE UNIT: COMBINATION OF SUPERIOR DETOXIFICATION AND EXCELLENT CARDIOVASCULAR TOLERABILITY IN SEVERELY ILL PATIENTS Jan T. Kielstein, Ulrich Kretschmer, Thomas Ernst, Carsten Hafer, Hermann Haller, Danilo Fliser. Nephrology, Medical School Hannover, Hannover, Germany

W382 HAEMOFILTER LIFETIMES WITH HIGH DOSE CRRT AND REASONS FOR HAEMOFILTER DISCONTINUATION Detlef Kindgen-Milles,1 Robert Pohlmeier,2 Eckhard Mueller.1 1Klinik für Anästhesiologie, Univ.klinikum Düsseldorf, Düsseldorf, Germany; 2Fresenius Medical Care, Bad Homburg, Germany

W383 EVALUATION OF THE SEVERITY OF COMPLICATIONS BY ACUTE RENAL FAILURE WITH MULTIPLE ORGAN FAILURE TREATED BY ON-LINE CONTINUOUS HAEMODIAFILTRATION Hideki Kawanishi, Touru Kawai, Kouji Watanabe, Misaki Moriishi, Shinichiro Tsuchiya. Art. Organs, Akane Found., Tsuchiya General Hosp., Hiroshima, Japan

407 WEDNESDAY, JUNE 12 POSTERS

W384 DIALYSIS-DEPENDENT ACUTE RENAL FAILURE (ARF) IN LIVER POST-TRANSPLANT (OLT) Antonio Santoro,1 Elena Mancini,1 Rossella Gaggi,1 Serena Bainotti,1 Silvia Pareschi,2 Stefano Faenza.2 1Malpighi Nephrology and Dialysis, Policlinico S.Orsola-Malpighi, Bologna, Italy; 2Institute of Anesthesiology and Intensive Care Medicine, Policlinico S.Orsola-Malpighi, Bologna, Italy

W385 WHICH PATIENTS BENEFIT FROM HEMODIALYSIS THERAPY IN HEPATORENAL SYNDROME (HRS)? O. Witzke, M. Baumann, D. Patschan, D. Eder, T. Philipp, A. Kribben. Dept. of Nephrology, University of Essen, Essen, Germany

W386 PHARMACOKINETICS AND TOTAL DIALYSATE CONCENTRATION OF VANCOMYCIN IN INTENSIVE CARE UNIT PATIENTS TREATED BY SLOW LOW-EFFICIENT DAILY DIALYSIS (SLED) Jan T. Kielstein,1 David Czock,2 Timo Schöpke,1 Stefanie M. Bode- Böger,3 Hermann Haller,1 Frieder Keller,2 Danilo Fliser.1 1Nephrology, Medical School Hannover, Hannover, Germany; 2Nephrology, University Hospital Ulm, Ulm, Germany; 3Institute of Clinical Pharmacology, Otto-von Guericke University, Magdeburg, Germany

W387 NEPHROTOXICITY OF COMBINATION ANTIBIOTIC THERAPY WITH VANCOMYCIN AND AMINOGLYCOSIDES Paolo Malacarne,1 Stefano Bergamasco,1 Carlo Donadio.2 1Unità di Anestesia e Rianimazione 2, Azienda Ospedale- UniversitàPisa, Italy; 2Medicina Interna - Nefrologia, University of Pisa, Pisa, Italy

W388 CAN ATRIAL NATRIURETIC PEPTIDE (ANP) EVADE DIALYSIS INDUCTION FOR ACUTE RENAL FAILURE? Masato Kasahara, Toshiko Tokoro, Takao Suzuki. Nephrology, Kobe General Hospital, Kobe, Hyogo, Japan

W389 ATRIAL NATRIUREIC PEPTIDE DECREASES THE INCIDENCE OF DIALYSIS AND IMPROVES DIALYSIS-FREE SURVIVAL IN ISCHAEMIC ACUTE RENAL FAILURE Kristina Sward,1 Felix Valsson,1 Per Odencrants,2 Ola Samuelsson,3 Sven-Erik Ricksten.1 1Cardiothoracic Anaestesia and Intensive Care, Sahlgrenska University Hospital, Goteborg, Sweden; 2Cardiothoracic Anaestesia and Intensive Care, Orebro University Hospital, Orebro, Sweden; 3Nephrology, Sahlgrenska University Hospital, Goteborg, Sweden

408 POSTERS WEDNESDAY, JUNE 12

CHRONIC RENAL FAILURE: MISCELLANEOUS WEDNESDAY

W390 PREVALENCE OF CHRONIC KIDNEY DISEASE IN LUTHERSTADT WITTENBERG. STRATEGIES TO PREVENT ENDSTAGE RENAL FAILURE Christiane Kirsten, Stephanie Siegert, Michael Uhlig, Klaus Graefner, Martina Jentzsch, Karlheinz Queck, Daniela Jehle, Peter Jehle. Internal Medicine and KfH Dialysis Unit, Hospital of the Paul- Gerhardt Foundation, Lutherstadt Wittenberg, Germany

W391 EPIDEMIOLOGY OF CHRONIC RENAL FAILURE IN A COMMUNITY BASED MASS SCREENING IN TEHRAN, IRAN Behzad Einollahi,1 Mohsen Nafar,2 Siamak Bakhtiari,1 Behzad Hajarizadeh,1 Mohamad Aghighi.2 1Nephrology, Baghyatollah University of Medical Sciences, Tehran, Iran; 2Dialysis and Organ Transplantation Center, Tehran, Iran

W392 PROSPECTIVE DATA ON THE ASSOCIATION BETWEEN ALCOHOL CONSUMPTION AND CHRONIC KIDNEY DISEASE Elke Schaeffner,1,2,3 Tobias Kurth,2,3 Robert Glynn,2 Julie Buring,2,3,4 Mike Gaziano.2,5 1Dept of Nephrology, University of Freiburg, Freiburg, Germany; 2Division of Preventive Medicine, Dept of Medicine, Brigham and Women’s Hospital, Boston, MA, USA; 3Dept of Epidemiology, Harvard School of Public Health, Boston, MA, USA; 4Dept of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA, USA; 5Massachusetts Veterans Epidemiology Research and Information Center, Boston, MA, USA

W393 IMPACT OF PRE-DIALYSIS EDUCATION ON THE QUALITY OF LIFE OF END-STAGE RENAL DISEASE (ESRD) PATIENTS Amy Guo,1 Y.C.T. Shih,2 Paul Just,1 Salim Mujais.1 1Renal Division, Baxter Healthcare, Deerfield, IL, USA; 2Dept of Biostatistics, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA

W394 INFLUENCE OF RENAL FUNCTION ON THE RESTING ENERGY EXPENDITURE (REE) OF CHRONIC RENAL INSUFFICIENCY (CRI) PATIENTS Carla Avesani, Sergio Draibe, Maria Ayako Kamimura, Silvia Regina Manfredi, Alessandra Pedrosa, Lilian Cuppari. Nephrology, Federal University of São Paulo, Sao Paulo, Brazil

W395 PRE-DIALYSIS SPECIALIST CARE AND SURVIVAL ON DIALYSIS: AN ATTEMPT TO CORRECT FOR LEAD TIME BIAS Pietro Ravani, Matteo Conca, Fabio Malberti. Divisione di Nefrologia e Dialisi, Istituti Ospitalieri, Cremona, Italy

W396 ANALYSIS OF LYMPHOCYTE SUBPOPULATION AND CYTOKINE mRNA LEVELS IN URAEMIC PATIENTS Masayuki Iyoda, Aki Kuroki, Tetsuzo Sugisaki. Department of Nephrology, Showa University, School of Medicine, Tokyo, Japan

W397 ADVANCED GLYCATION AND LIPOXIDATION END PRODUCTS IN CHRONIC RENAL INSUFFICIENCY Olga Mareckova,1 Vladimir Teplan,1 Otto Schuck,1 Jan Pokorny,2 Katarina Sebekova.3 1Department of Nephrology, Transplant Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 2Chemistry and Technology Department, Technical University, Prague, Czech Republic; 3Biochemical Department, Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic

409 WEDNESDAY, JUNE 12 POSTERS

W398 CARNITINE METABOLITES IN CHRONIC RENAL FAILURE: A TANDEM MASS SPECTROMETRY STUDY IN PRE-DIALYSIS, MAINTENANCE HAEMODIALYSIS AND KIDNEY TRANSPLANT PATIENTS Kazunori Nakamura,1 Fitsum Guebre-Egziabher,1 S. Cognat,2 Christine Vianey-Saban,2 Aoumeur Hadj-Aissa,3 Jacques Bernhard,1 Denis Fouque.1 1Nephrology, Hop E.Herriot, Lyon, France; 2Pediatric Bioch., Hop Debrousse, Lyon, France; 3Renal Phys., Hop E.Herriot, Lyon, France

W399 MANAGEMENT OF BLEEDING IN URAEMIC PATIENTS USING RECOMBINANT ACTIVATED FACTOR VII Viorica Bumbea,1 Horia Bumbea,2 Luminita Ardelean,1 Oana Constantinescu.1 1Dialysis, Emergency Hosp., Bucharest, Romania; 2Hemathology, Coltea Hosp., Bucharest, Romania

W400 DRUGS ‘ HANDLING IN PATIENTS WITH RENAL FAILURE: THE ICAR EXPERIENCE Nathalie Jourdan-Da Silva,1 Vincent Launay-Vacher,2 Sophie Tezenas Du Montcel,1 Lucile Cousin,2 Marie Le Berre,2 Gilbert Deray,2 Corinne Isnard Bagnis.2 1Dept of Biostatistics and Medical Informatics, Pitie Salpetriere Hosp., Paris, France; 2Dept of Nephrology, Pitie Salpetriere Hosp., Paris, France

W401 HISTAMINE AND URAEMIC PRURITUS Rossitsa Zortcheva, Anna Belcheva, Kyril Nenov. 1Clin. of Nephrologye, Hemodialysis and Toxicology, Medical Univ. of Varna, Varna, Bulgaria; 2Div. of Preclinical and Clinical Pharmacology, Medical Univ. of Varna, Varna, Bulgaria; 3Clin.of Nephrology, Hemodialysis and Toxicology, Medical Univ. of Varna, Varna, Bulgaria

W402 PHARMACOLOGICAL IMPROVEMENT OF DIAPHRAGMATIC DYSFUNCTION IN 5/6 NEPHRECTOMIZED RATS Jose Boggia, Maria Jose Rodriguez, Rosana Perez, Oscar Noboa, Liliana Gadola. Dept de Fisiopatologia, Fac. de Medicina - Univ. de la Republica, Montevideo, Uruguay

W403 INCIDENCE AND SPECTRUM OF MALIGNANT DISEASE AMONG DIALYSIS PATIENTS IN NORTH BAVARIA Markus Teschner,1 Cornelia Garte,1 Udo Bahner,1 Uwe Mäder,5 André Klassen,5 Heide Rückle-Lanz,5 Helga Stopper,5 Hans-Martin Hennemann,2 Walter Schulz,3 Josef Nikolay,4 August Heidland.5 1KfH Würzburg, Health Care Centre, Würzburg, Bavaria, Germany; 2KfH Coburg, Health Care Centre, Coburg, Bavaria, Germany; 3KfH Bamberg, Health Care Centre, Bamberg, Bavaria, Germany; 4KfH Fürth, Health Care Centre, Fürth, Bavaria, Germany; 5Dept of Internal Medicine, Univ. of Würzburg, Würzburg, Bavaria, Germany

W404 SURVIVAL OF END STAGE RENAL FAILURE PATIENTS WITH CANCER Angela Webster,1,2,3,4 Jonathan Craig,1,2,4 Jeremy Chapman.2,3,4 1Centre for Kidney Research, Children’s Hosp., Westmead, NSW, Australia; 2Faculty of Medicine, Univ. of Sydney, NSW, Australia; 3Dept of Renal Medicine, Westmead Hosp., NSW, Australia; 4ANZDATA Registry, Adelaide, SA, Australia

W405 DIFFICULTIES IN PSYCHO-SOCIAL ADAPTATION AND DEATH- RELATED FANTASIES IN PATIENTS WITH CHRONIC RENAL FAILURE (CRF) Ingrid L.F. Viégas,1 Rosemeire Nascimento,1 Ingrid A. Medeiros,1 Regina C.R.M. Abdulkader.2 1Div. de Psicologia, Hosp. das Clínicas, FMUSP, São Paulo, SP, Brazil; 2Serviço/Disciplina de Nefrologia, Hosp. das Clínicas, FMUSP, São Paulo, SP, Brazil

410 POSTERS WEDNESDAY, JUNE 12

W406 GASTRIC EMTYING IN PATIENTS ON RENAL REPLACEMENT THERAPY Musa Bali,1 Galip Guz,1 Nilufer Yildirim,2 Oktay Bagdatoglu,1 Zeynep Yegin,1 Tamer Atasever,2 Yasemin Erten,1 Ibrahim Dogan,3 WEDNESDAY Sevki Sert.4 1Nephrology, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey; 2Nuclear Medicine, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey; 3Gastroenterology, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey; 4Transplantation Unit, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey

W407 IS SOLUBLE Fas (s-Fas) ONE OF URAEMIC TOXINS? Masashi Sato, Teruko Kogure, Naoki Yanagisawa, Hisatoshi Haizuka, Yutaka Nakashima. 4th Dept of Int Med, Teikyo Univeresity School of Medicine, Kawasaki, Japan

W408 PREVALENCE OF BIOCHEMICAL HYPOGONADISM IN MALE PRE_DIALYSIS AND RENAL REPLACEMENT THERAPY (RRT) PATEINTS Fouad Albaaj,1 M. Sivalingham,1 Peter Haynes,2 Graham McKinnon,3 Philip Kalra.1 1Renal Medicine, Hope Hospital, Salford, Greater Manchester, United Kingdom; 2Rheumatology, Royal Oldham Hospital, Oldham, Greater Manchester, United Kingdom; 3Endocrine Biochemistry, Hope Hospital, Salford, Greater Manchester, United Kingdom

W409 “FIT FUER DIALYSE” - AN EDUCATION INITIATIVE FOR KIDNEY PATIENTS Werner Riegel, Guenter Boettner, Ralf Schellhase. Fit fuer Dialyse, Initiative, Darmstadt, Germany

W410 HIGH PREVALENCE OF PERIODONTAL PATOLOGY IN CRF PATIENTS Adalbert Schiller,1 Eleonora Schiller,2 Gheorghe Gluhovschi,1 Ovidiu Golea,3 Virginia Trandafirescu,1 Ligia Petrica.1 1Clinic of Nephrology, University of Medicine and Pharmacy, Timisoara, Timis, Romania; 2Faculty of Dentistry, University of Medicine and Pharmacy, Timisoara, Timis, Romania; 3Dialysis Center, County Hospital, Timisoara, Timis, Romania

W411 THE INFLUENCE OF CHRONIC RENAL FAILURE ON AUTONOMIC NERVOUS FUNCTION Radoslav Kveder,1 Aljosa Kandus,1 Sasa Sega,2 Andrej Kveder,3 Andrej Bren.1 1Department of Nephrology, University Medical Center Ljubljana, Ljubljana, Slovenia; 2Department of Neurology, University Medical Center Ljubljana, Ljubljana, Slovenia; 3Scientific Research Center, Slovenian Academy of Science, Ljubljana, Slovenia

W412 ESOPHAGEAL MANOMETRY IN ADVANCED CHRONIC RENAL INSUFFICIENCY Gopesh K. Modi,1 Vinod Narkhede,2 Nasir J. Iqbal,1 Virendra Tewari,3 Subodh Varshney.2 1Nephrology, Bhopal Memorial Hospital & Research Center, Bhopal, MP, India; 2Gastrointestinal Surgery, Bhopal Memorial Hospital & Research Center, Bhopal, MP, India; 3Gastroenterology, Bhopal Memorial Hospital & Research Center, Bhopal, MP, India

411 WEDNESDAY, JUNE 12 POSTERS

CALCIUM, MAGNESIUM, PHOSPHATE AND PHOSPHATE BINDERS

W413 CONTROL OF PHOSPHATEMIA WITH SHORT DAILY HEMODIALYSIS Roula Galland, Jules Traeger, Marie Laure Ferrier, Ehsan Delawari. Association pour Utilisation du Rein Artificiel, (AURAL), Lyon, France

W414 PREVALENCE OF VALUES ON MINERAL METABOLISM BEING OUTSIDE THE TARGETS FROM THE PROPOSED NEW DRAFT NKF-K/DOQI AND EUROPEAN BEST PRACTICE GUIDELINES IN COUNTRIES OF THE DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (DOPPS) Eric Young,1 Sudtida Satayathum,2 Ronald Pisoni,2 Francesco Locatelli,3 Bernard Canaud,4 Kiyoshi Kurokawa,5 Takashi Akiba,6 Akira Saito,5 Donna Mapes,7 Friedrich Port.2 1Nephrology, VAMC/Univ. of Michigan, Ann Arbor, MI, USA; 2DOPPS, URREA, Ann Arbor, MI; 3Nephrology, A Manzoni Hosp., Lecco, Italy; 4Nephrology, Lapeyronie Univ. Hosp., Montpellier, France; 5Medicine, Tokai Univ., Kanagawa, Japan; 6Medicine, Tokyo Women’s Medical Univ., Tokyo, Japan; 7Dialysis Medical Affairs, Amgen, Thousand Oaks, CA, USA

W415 PREDICTORS OF HYPERPHOSPHATEMIA AND ITS ASSOCIATION WITH CARDIOVASCULAR DEATHS AND HOSPITALIZATION IN CHRONIC HAEMODIALYSIS PATIENTS: INTERNATIONAL RESULTS FROM THE DOPPS Ronald Pisoni,1 Sudtida Satayathum,1 Eric Young,2 Takashi Akiba,3 Tadao Akizawa,4 Kiyoshi Kurokawa,5 Francesco Locatelli,6 Christian Combe,7 Bradley Maroni,8 Friedrich Port.1 1DOPPS, URREA, Ann Arbor, MI, USA; 2Nephrology, VAMC/Univ. of Michigan, Ann Arbor, MI, USA; 3Medicine, Tokyo Women’s Medical Univ., Tokyo, Japan; 4Medicine, Wakayama Medical Univ., Wakayama, Japan; 5Medicine, Tokai Univ., Kanagawa, Japan; 6Nephrology, A Manzoni Hosp., Lecco, Italy; 7Medicine, Hop. St- Andre, Bordeaux, France; 8Clinical Research/Nephrology, Amgen, Thousand Oaks, CA, USA

W416 PREDICTORS AND CONSEQUENCES OF SERUM CALCIUM CONCENTRATION IN THE DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (DOPPS) Eric Young,1 Sudtida Satayathum,2 Akira Saito,3 Takashi Akiba,4 Yasushi Asano,5 Vittorio Andreucci,6 Luis Piera,7 Francesco Locatelli,8 Friedrich Port.2 1Nephrology, VAMC/Univ. of Michigan, Ann Arbor, MI, USA; 2DOPPS, URREA, Ann Arbor, MI, USA; 3Medicine, Tokai Univ., Kanagawa, Japan; 4Medicine, Tokyo Women’s Medical Univ., Tokyo, Japan; 5Medicine, Jichi Medical School, Tochigi, Japan; 6Nephrology, Univ.Federico II, Naples, Italy; 7Nephrology, Hosp. General Vall d’Hebron, Barcelona, Spain; 8Nephrology, A Manzoni Hosp., Lecco, Italy

W417 A MODEL TO DETERMINE INORGANIC PHOSPHOROUS (P) INTAKE (GENERATION, GP) AND REMOVAL BY HAEMODIALYSIS (HD,JdP) AND BINDERS (JbP) Frank Gotch,1 Froilan Panlilio,2 Laura Rosales,1 Olga Sergeyeva,1 Tom Folden,2 George Kaysen,3 Nathan Levin.1 1Nephrology, Renal Research Inst., New York, NY, USA; 2Nephrology, Fresenius Medical Care NA, Walnut Creek, CA, USA; 3Div.of Nephrology/ Dept. of Internal Med., Univ. of California, Davis, CA, USA

W418 LONG TERM CONTROL OF PHOSPHATE (PO4) AND PARATHYROID HORMONE (PTH) IN CHILDREN WITH CHRONIC RENAL FAILURE Martin Christian, Charles Turner, Christopher Reid, Susan Rigden. Paediatric Nephrology, Guy’s Hospital, London, United Kingdom

412 POSTERS WEDNESDAY, JUNE 12

W419 PERSISTENT HYPERPHOSPHATEMIA AFTER EFFECTIVE PARATHYROIDECTOMY IN DIALYSIS PATIENTS Alessandra Barbosa,1 Fellype Barreto,1 Graziella Leme,1 Rodrigo Santos,2 Fabiana Rodrigues,1 Andrea Higa,1 Lillian Rocha,1 Rosélia WEDNESDAY Lobão,1 Aluizio Carvalho.1 1Nephrology Division, Escola Paulista de Medicina - UNIFESP, São Paulo, Brazil; 2Head and Neck Surgery Division, Escola Paulista de Medicina - UNIFESP, São Paulo, Brazil

W420 ROLE OF CHETOANALOGUES ON CALCIUM-PHOSPHATE METABOLISM AND ANAEMIA OF HAEMODIALYSIS PATIENTS: A PILOT CONTROLLED RANDOMIZED STUDY Maria Carla Bigi, Simeone Andrulli, Pietro Pozzoni, Francesco Locatelli. Neprhology and Dialysis, A. Manzoni Hospital, Lecco, Italy

W421 COMPARISON OF A NEW PHOSPHATE BINDER, A MAGNESIUM IRON HYDROXY CARBONATE COMPOUND (MFHC), WITH OTHER PHOSPHATE BINDERS N.B. Roberts,1 M. Sargazi,1 N.P. Rhodes,2 S. Parry,2 A. Toft.2 1Dept of Clinical Chemistry, Royal Liverpool University Hospital, Liverpool, UK; 2INEOS Silicas Ltd, Warrington, UK

W422 EFFECTIVE REDUCTION OF SERUM PHOSPHATE BY A CALCIUM AND MAGNESIUM CONTAINING PHOSPHATE BINDER WITHOUT INDUCTION OF HYPERMAGNESEMIA Heinz Juergen Deuber. KfH, Dialysis Center, Erlangen, Germany

W423 THORACIC VERTEBRAL BONE DENSITY INCREASES WITH RENAGEL AND DECREASES WITH CALCIUM-BASED PHOSPHATE BINDER THERAPY - A TWO YEAR STUDY George James,1 Paolo Raggi,1 Amy Boulay,2 Steven Burke,2 Scott Chasan-Taber,3 Glenn Chertow,4 Herwig Holzer,5 Juergen Bommer.6 1Section of Cardiology, Tulane Univ., New Orleans, LA, USA; 2GelTex Pharmaceuticals, Waltham, MA, USA; 3Pioneer Biodiligence, Amherst, MA, USA; 4Division of Nephrology, Univ.of California, San Francisco, CA, USA; 5Medizinische UniversitätsklinikKlinische Abteilung für Nephrologie, Universitätsklinikum Graz, Graz, Austria; 6Sektion Nephrology, Klinikum der Univ.Heidelberg, Heidelberg, Germany

W424 ACID-BASE EQUILIBRIUM CHANGES IN SEVELAMER HYDROCHLORIDE TREATED HAEMODIALYSIS PATIENTS Macroui Sonikian,1 Ioanna Pani,1 Ioannis Karatzas,2 Anastasios Iliopoulos,2 Stamatia Marioli,2 Dimosthenis Vlassopoulos.1 1Nephrology, A Fleming Hospital, Athens, Greece; 2Biochemistry, A Fleming Hospital, Athens, Greece

W425 SEVELAMER VS. CALCIUM ACETATE IN CHILDREN WITH CHRONIC RENAL FAILURE Anne-Kathrin Pieper,1 Dieter Haffner,1 Regula Müller-Hönger,2 Bernd Hoppe,3 Christian Plank,4 Gisela Offner,5 Klaus-Eugen Bonzel,6 Ulrike John,7 Stefan Fründ,8 Günter Klaus,9 Amrey Link,10 Gesche Düker,11 Uwe Querfeld.1 1Paediatric Nephrology, Charite, Humboldt University, Berlin, Germany; 2Genzyme Europe, Naarden, Netherlands; 3University Children´s Hospital, Köln, Germany; 4University Children´s Hospital, Erlangen, Germany; 5University Children´s Hospital, Hannover, Germany; 6University Children´s Hospital, Essen, Germany; 7University Children´s Hospital, Jena, Germany; 8University Children´s Hospital, Münster, Germany; 9University Children´s Hospital, Marburg, Germany; 10University Children´s Hospital, Hamburg, Germany; 11University Children´s Hospital, Bonn, Germany

413 WEDNESDAY, JUNE 12 POSTERS

W426 INTERESTING FINDINGS AFTER TWO YEARS TREATMENT WITH SEVELAMER HYDROCHLORIDE Macroui Sonikian,1 Ioanna Pani,1 Ioannis Karatzas,2 Kaliopi Koutala,2 Stamatia Marioli,2 Dimosthenis Vlassopoulos.1 1Nephrology, A Fleming Hospital, Athens, Greece; 2Biochemistry, A Fleming Hospital, Athens, Greece

W427 HYPOCHOLESTEROLAEMIC EFFECT OF SEVELAMER IN DIABETICS AND NON-DIABETICS HAEMODIALYZED PATIENTS Angela Marino, Nicola Giotta. Department of Medicine, Unit of Nephrology, Asti, Italy

W428 COMPARATIVE EFFECTS OF LANTHANUM CARBONATE (FOSRENOL™) AND CALCIUM CARBONATE ON RENAL BONE DISEASE IN DIALYSIS PATIENTS: RESULTS FROM A LARGE, LONG-TERM CLINICAL TRIAL M.E. De Broe,1 P.C. D’Haese,1 T.J. Freemont,2 I. Webster,3 M. Gill,3 G.B. Spasovski.4 1Dept. Nephrology, Univ. Antwerp, Antwerp, Belgium; 2Musculo- Skeletal Research Group, Univ. Manchester, Manchester, UK; 3Research & Development, Shire Pharmaceutical Development Ltd, Basingstoke, UK; Dept. Nephrology, Univ. Skopje, Skopje, F.Y.R.M.

W429 THE PHARMACOLOGY OF A NEW PHOSPHATE BINDER, LANTHANUM CARBONATE Stephen J.P. Damment, Wilson Totten. Preclinical Sciences, Shire Pharmaceutical Development Ltd, Basingstoke, Hampshire, United Kingdom

W430 EFFECTS OF LANTHANUM AND STRONTIUM ON OSTEOBLASTS IN CHRONIC RENAL FAILURE RATS Geert Behets,1 An Bervoets,1 Geert Dams,1 Stephen Damment,2 Marc De Broe,1 Patrick D’Haese.1 1Dept of Nephrology - Hypertension, Univ. of Antwerp, Antwerp, Belgium; 2Shire Pharmaceutical Development Ltd., Hampshire, UK

W431 PHOSPHATE SUPPLEMENTATION NORMALIZES CHANGES IN BONE MINERALIZATION IN URAEMIC RATS GIVEN HIGH DOSES OF LANTHANUM CARBONATE Stephen Damment,1 Victor Shen,2 Isobel Webster.1 1Preclinical Sciences, Shire Pharmaceutical Development Ltd, Basingstoke, Hampshire, United Kingdom; 2Osteoporosis Research, Skeletech Inc, Seattle, WA, United States

W432 SAFETY AND TOLERABILITY OF LANTHANUM CARBONATE IN HAEMODIALYSIS PATIENTS: A 12-MONTH STUDY A. Hutchison,1 I. Webster,2 M. Gill,2 R. Schmieder.3 1Manchester Institute of Nephrology & Transplantation, University of Manchester, Manchester, Greater Manchester, United Kingdom; 2Clinical, Shire Pharmaceuticals Group PLC, Basingstoke, Hampshire, United Kingdom; 3Department of Medicine, Universität Erlangen-Nürnberg, Erlangen, Germany

W433 LANTHANUM CARBONATE (FOSRENOL™) DOES NOT HAVE A CLINICALLY SIGNIFICANT EFFECT ON THE PHARMACOKINETICS OF DIGOXIN, WARFARIN OR METOPROLOL G. Fiddler,1 J. Täubel,2 I. Webster,1 M. Gill.1 1Clinical, Shire Pharmaceutical Development Ltd, Basingstoke, Hampshire, United Kingdom; 2Richmond Pharmacology Limited, Atkinson Morley’s Hospital, Wimbledon, Surrey, United Kingdom

414 POSTERS WEDNESDAY, JUNE 12

W434 LONG-TERM TREATMENT WITH LANTHANUM CARBONATE (FOSRENOL™) IS SAFE AND EFFECTIVE IN HAEMODIALYSIS PATIENTS W.F. Finn,1 M.S. Joy,1 I. Webster,2 M. Gill.2 WEDNESDAY 1Department of Medicine, University of North Carolina, Chapel Hill, NC, United States; 2Clinical, Shire Pharmaceutical Development Ltd, Basingstoke, Hampshire, United Kingdom

W435 LONG-TERM SAFETY, TOLERABILITY AND EFFICACY OF LANTHANUM CARBONATE IN HAEMODIALYSIS PATIENTS: AN EXTENSION STUDY TO A PHASE II TRIAL M.S. Joy,1 G. Fiddler,2 W.F. Finn,1 I. Webster,2 M. Gill.2 1Dept of Medicine, University of North Carolina, Chapel Hill, NC, United States; 2Clinical, Shire Pharmaceutical Development Inc., Basingstoke, Hampshire, United Kingdom

W436 THE IMPACT OF LANTHANUM CARBONATE AND CALCIUM CARBONATE ON RENAL BONE DISEASE IN DIALYSIS PATIENTS - SINGLE CENTER EXPERIENCE Goce Spasovski,1 Aleksandar Sikole,1 Saso Gelev,1 Risto Grozdanovski,1 Vili Amitov,1 Patrick D’Haese,2 Marc De Broe.2 1Department of Nephrology, Clinical Center Skopje, University of Skopje, Skopje, F.Y.R.M.; 2Department of Nephrology-Hypertension, University Hospital Antwerp, University of Antwerp, Antwerp, Belgium

W437 LANTHANUM CARBONATE (FOSRENOL™) CAUSES SIGNIFICANT REDUCTIONS IN SERUM PHOSPHORUS AND Ca × P PRODUCT IN A DOSE-RANGING, PLACEBO-CONTROLLED STUDY W. Finn,1 M. Joy,1 I. Webster,2 M. Gill.2 1Department of Medicine, University of North Carolina, Chapel Hill, NC, United States; 2Clinical, Shire Pharmaceutical Development Ltd, Basingstoke, Hampshire, United Kingdom

W438 A LONG-TERM (2-YEAR) ASSESSMENT OF THE SAFETY AND EFFICACY OF LANTHANUM CARBONATE (FOSRENOL™), A NON-CALCIUM, NON-ALUMINIUM PHOSPHATE BINDER FOR THE TREATMENT OF HYPERPHOSPHATAEMIA W.F. Finn,1 M.S. Joy,1 I. Webster,2 M. Gill.2 1Division of Nephrology & Hypertension, University of North Carolina, Chapel Hill, NC, United States; 2Clinical, Shire Pharmaceutical Development Ltd, Basingstoke, Hampshire, United Kingdom

W439 EFFECTIVE CONTROL OF INTRACTABLE HYPERCALCEMIA BY REGULAR DOSE OF PAMIDRONATE IN DIALYSIS PATIENTS Kook Hwan Oh,1 Won Kyung Byon,2 Hee Sook Nam,2 Curie Ahn.2 1Internal Medicine, Hallym University, Seoul, Korea; 2Internal Medicine, Seoul National University, Seoul, Korea

415 WEDNESDAY, JUNE 12 POSTERS

ANAEMIA: MISCELLANEOUS

W440 ADEQUACY OF ANEMIA MANAGEMENT IN THE NETHERLANDS Femke van der Sman-de Beer,1 Johanna C. Korevaar,2 Aantje V. Kharagjitsingh,3 Jeannette G. van Manen,2 Elisabeth W. Boeschoten,4,5 Raymond T. Krediet,4 Friedo W. Dekker.1 1Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands; 2Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, Netherlands; 3Internal Medicine, Leiden University Medical Center, Leiden, Netherlands; 4Nephrology, Academic Medical Center, Amsterdam, Netherlands; 5Dianet Dialysiscenters, Academic Medical Center, Amsterdam, Netherlands

W441 THE EUROPEAN SURVEY ON ANAEMIA MANAGEMENT (ESAM) 2003: HAS MEDICAL PRACTICE IN RELATION TO ANAEMIA MANAGEMENT OF PATIENTS WITH CHRONIC RENAL FAILURE CHANGED IN THE 4 YEARS SINCE ESAM? Claude Jacobs, on Behalf of the ESAM 2003 Study Group. Service de Néphrologie, Hôpital de la Pitié Salpétrière, Paris, France

W442 GENDER SPECIFIC HAEMOGLOBIN MAY BE MORE APPROPRIATE THAN ABSOLUTE HAEMOGLOBIN IN THE ASSESSMENT OF ANAEMIA IN CHRONIC KIDNEY DISEASE John Duncan,1 Rebecca Mitchell,1 Ognjenka Djurdjev,2 Adeera Levin.2 1Division of Nephrology, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada; 2Division of Nephrology, St. Pauls Hospital, Providence Health Care, Vancouver, BC, Canada

W443 GEOGRAPHIC VARIATIONS IN ANAEMIA MANAGEMENT IN EUROPEAN DIALYSIS PATIENTS: BASELINE DATA FROM THE ARANESP® (DARBEPOETIN ALFA) EUROPEAN STUDIES PROGRAMME Johann Braun, on Behalf of the Aranesp European Studies KfH Kuratorium fuer Dialyse und Nierentransplantation, Nuernberg, Germany

W444 IMPROVING MANAGEMENT OF ANAEMIA IN PRE-DIALYSIS PATIENTS. A REPORT FROM THE UK RENAL REGISTRY Christopher Burton,1 David Ansell,2 Kate Thomas,2 David Throssel,3 Terry Feest.2 1Richard Bright Renal Unit, North-Bristol NHS Trust, Southmead, Bristol, United Kingdom; 2UK Renal Registry, Southmead Hospital, Bristol, United Kingdom; 3Sheffield Kidney Institute, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom

W445 FACTORS ASSOCIATED WITH SUBOPTIMAL HAEMOGLOBIN (Hb) CONCENTRATIONS DESPITE HIGH DOSE RECOMBINANT HUMAN ERYTHROPOIETIN (rHuEPO) Jose Matias Tabernero, on Behalf of the Aranesp® European Studies Programme. Servicio de Nefrologia, Jose Luis Lerma H. Hospital Clinico de Salamanca, Salamanca, Spain

W446 VARIABLES ASSOCIATED WITH DIALYSIS PATIENTS’ ACHIEVEMENT OF TARGET HAEMOGLOBIN: BASELINE RESULTS FROM THE ARANESP® (DARBEPOETIN ALFA) EUROPEAN STUDIES PROGRAMME Iain Macdougall.1,2 1Department of Renal Medicine, King’s College Hospital, London, United Kingdom; 2on Behalf of the Aranesp® European Studies Programme

416 POSTERS WEDNESDAY, JUNE 12

W447 A HIGH EPO/HEMOGLOBIN RATIO IS AN INDEPENDENT PREDICTOR OF HAEMODIALYSIS PATIENT MORTALITY Francesc Moreso,1 Mihály Tapolyai,2 Juan Antonio Ayala,3 Ramon Rentero,3 Daniele Marcelli.2 WEDNESDAY 1Hemodialysis Unit, Inst. Nefrologic, Barcelona, Spain; 2Clin. Management Europe, Bad Homburg, Germany; 3FMC Spain, Madrid, Spain

W448 IMPACT OF HEPATITIS VIRUSES B, AND C ON THE MANAGEMENT OF ANAEMIA IN CHRONIC RENAL FAILURE PATIENTS ON REGULAR HAEMODIALYSIS Magdy El-Sharkawy,1 Essam Khedr,1 Medhat Ali,1 Mohamed El- Esawy,1 Abla Ibraheem.2 1Internal Med. & Nephrology, Ain-Shams Univ., Cairo, Egypt; 2Ain- Shams Univ., Cairo, Egypt

W449 ROLE OF HELICOBACTER PYLORI INFECTION IN THE ANAEMIA OF HAEMODIALYSIS PATIENTS Thais Lopez, Jaume Almirall, Xavier Calvet, Isabel Sanfeliu, Mariela Quesada, Manuel Garcia. Nephrology, Gastroenterology and Microbiologyory, Corporacio Parc Tauli-Institut Univ. Parc Tauli (UAB), Sabadell, Barcelona, Spain

W450 DECREASED ERYTHROPOIETIN REQUIREMENTS DESPITE SEVERE HYPERPARATHYROIDISM - EFFECT OF PARICALCITOL? Suhail Shuja, Rasib Raja. Div. of Nephrology, Albert Einstein Medical Ctr, Philadelphia, PA, USA

W451 RESPONSIVENESS TO ERITHROPOIETIN (EPO) IN PRE-DIALYSIS CHRONIC RENAL FAILURE (CRF) IS AMELIORATED BY SUPPLEMENTED VERY LOW PROTEIN DIET Biagio R. Di Iorio,1 Vincenzo Bellizzi,2 Roberto Minutolo,4 Luca De Nicola,4 Carmela Iodice,3 Roberto Rubino,3 Giuseppe Conte.4 1Nephrology-Dialysis Unit, County Hosp., Solofra; 2Polla; 3Ariano Irpino; 4Chair of Nephrology, Second Univ.of Naples, Naples, Italy

W452 INVESTIGATIONS ON THE ALTERATION OF ANIONIC BINDING PROTEIN IN RED BLOOD CELL OF ACUTE AND CHRONIC RENAL FAILURE PATIENTS Ramasamy Sakthivel, Varadharaj Saradha Devi, Ramasamy Selvam, Palaninathan Varalakshmi. Dept of Medical Biochemistry, Dr. ALM Post Graduate Inst. of Basic Med. Sciences, Univ.of Madras,Taramani Campus, Chennai, Tamil Nadu, India

W453 INTRA- AND POST-DIALYTIC CHANGES OF HAEMOGLOBIN LEVELS IN NON-ANAEMIC URAEMIC PATIENTS Roberto Minutolo,1 Luca De Nicola,1 Giuseppe Conte,1 Vincenzo Bellizzi,2 Felice Nappi,3 Ferdinando Avella,3 Carmine Stallone,4 Filippo Aucella,4 Carmela Iodice,5 Roberto Rubino,5 Biagio R. Di Iorio.6 1Nephr. Dept., II Univ.of Naples, Naples; 2Nephrology-Dialysis Unit, County Hosp., Polla; 3Nola; 4S. Giovanni Rotondo; 5Ariano Irpino; 6Solofra, Italy

W454 EFFECT OF HIGH-FLUX HAEMODIALYSIS ON ANAEMIA CORRECTION OF ESRD PATIENTS. SAMPLE SIZE ASSESSMENT FOR A RANDOMIZED CONTROLLED TRIAL (RCT) Bruno Cianciaruso,1 Attilio Di Benedetto,2 Bruno Memoli,1 Giovanni Buccino,3 Roberto Di Donato,3 Giulia Pacchiano,3 Raffaele Iandolo,3 Maria Palma Iavarone,3 Enrico De Felice,3 Giacomo Policastro,3 Maria Grazia Buccino,3 Marco Ventre,3 Daniele Marcelli,4 1Nephrology, Univ. of Naples "Federico II".School of Med., Naples, Italy; 2Med. Direction, Fresenius Medical Care - Nephrocare, Naples, Italy; 3Nephrocare Study Group, Naples, Italy; 4Clinical Manag. Europe, Fresenius Medical Care, Bad-Homburg, Germany

417 WEDNESDAY, JUNE 12 POSTERS

W455 A COMPARATIVE STUDY OF NANDROLONE DECANOATE AND ERYTHROPOIETIN ON ALBUMIN LEVELS, QUALITY OF LIFE, AND PROGRESSION OF RENAL DISEASE IN INDIAN PREDIALYSIS CKD PATIENTS Anirban Ganguli, N.P. Singh, N. Ahuja. 1Deptt of Medicine, Maulana Azad Medical College and Asso Hospitals, New Delhi, NCT, Delhi, India; 2N.P.Singh, Maulana AzadMedical College and Asso Hospitals, New Delhi, NCT, Delhi, India; 3Neeraj Ahuja, Maulana Azad Medical College and Asso Hospitals, New Delhi, NCT, Delhi, India

W456 A COMPARATIVE STUDY OF NANDROLONE DECANOATE VERSUS RECOMBINANT HUMAN ERYTHROPOIETIN ON ANEMIA IN INDIAN PREDIALYSIS CHRONIC KIDNEY DISEASE PATIENTS N.P. Singh, Anirban Ganguli, T. Singh. 1Department of Nephrology, Maulana Azad Medical College and Associated Hospitals, New Delhi, NCT, Delhi, India; 2Department of Nephrology, Maulana Azad Medical College and Associated Hospitals, New Delhi, NCT, Delhi, India; 3Department of Pathology, Maulana Azad Medical College and Associated Hospitals, New Delhi, NCT, Delhi, India

W457 OXYGEN AFFINITY, 2,3-BPG AND ATP IN RENAL ANAEMIA AND AFTER ITS CORRECTION BY EXOGENOUS ERYTHROPOIETIN OR RENAL TRANSPLANTATION Uwe Kuhlmann, Harald Lange. Clinic of Internal Medicine, Dept. Nephrology, University of Marburg, Marburg, Germany

418 POSTERS WEDNESDAY, JUNE 12

DIALYSIS CARDIOVASCULAR RISK IN ESRD, HOMOCYSTEINE WEDNESDAY

W458 HOMOCYSTEINE INDUCES MONOCYTE CHEMOATTRACTANT PROTEIN-1 EXPRESSION VIA NUCLEAR FACTOR KAPPA-B PATHWAY O. Karmin, Giselle T.Y. Cheung, Yi Shi, Yaw Y. Siow. Pharmacology, The University of Hong Kong, Hong Kong, China

W459 THE ACHIEVEMENT OF NORMAL HOMOCYSTEINEMIA (sHCY) IN REGULAR EXTRACORPOREAL DIALYSIS (RDT) PATIENTS (PTS) Marco Gonella,1 Giovanni Calabrese,1 Andrea Mengozzi,2 Antonio Giuseppe Aleo,2 Giuseppe Vagelli,1 Giuseppe Pratesi,1 Antonio Mazzitta,1 Pier Carlo De Ambrogio.2 1Renal Unit, 2Lab. of Clinical Pathology, General Hosp., Casale Monferrato, Alessandria, Italy

W460 COMPARISON OF THE EFFECT OF TWO DIFFERENT DOSE SCHEDULES OF FOLIC ACID ON THE HOMOCYSTEINE SERUM LEVELS IN HAEMODIALYSIS PATIENTS Efthemia Mourvati,1 Athanasia Agorasti,2 Apostolos Kyrgialanis,1 Agellos Goutzouvelidis,1 Despoina Konstantinidou,2 Hristos Hatzidimitriou.1 1Renal Unit, 2Lab. of Hematology, General Hosp., Xanthi, Greece

W461 THE HOMOCYSTEIN LEVEL AND RISK ACTORS OF CARDIOVASCULAR COMPLICATIONS IN THE PATIENTS WITH END STAGE RENAL DISEASE ON DIFFERENT DIALYSIS MODALITIES Kirill Komissarov,1 Svetlana Zolotukhina,2 Valery Pilotovich,1 Alexey Gorunov.1 1Nephrology, National Centre of Nephrology, Dialysis & Kidney Transpl., Minsk, Belarus; 2Biochemistry, Republic Scientific and Practical Center “Cardiology” Minsk, Belarus

W462 HYPERHOMOCYSTEINAEMIA IN HAEMODIALYSIS PATIENTS IS A CARDIOVASCULAR RISK: COULD THE ENDOTHELIAL DYSFUNCTION BE A LINK? Hala El Wakil,1 Nadia Barghash,2 Sahar Azab.3 1Int. Med., 2Med. Biochemistry, 3Cardiology, Fac. of Med. - Alexandria Univ., Alexandria, Egypt

W463 THE IMPACT OF ATORVASTATIN THERAPY AND LOWERING PLASMA HOMOCYSTEINE LEVELS ON THE PROGRESSION OF CARDIOVASCULAR DAMAGE IN HAEMODIALYSIS PATIENTS. PRELIMINARY RESULTS Carlo Massimetti,1 Franco Brescia,2 Daniele Pontillo,3 Sabina Ficili,3 Maria Teresa Muratore,4 Valerio Maria Bonavia,4 Enzo Ancarani.1 1Nephrology & Dialysis, Belcolle Hospital, Viterbo, Italy; 2Radiology, Belcolle Hospital, Viterbo, Italy; 3Cardiology, Belcolle Hospital, Viterbo, Italy; 4Chemistry, Belcolle Hospital, Viterbo, Italy

W464 HOMOCYSTEINE, FOLATE THERAPY AND OUTCOME IN HAEMODIALYSIS: A PROSPECTIVE STUDY Andrea Campo, Franco Goia, Roberto Cottino, Marina Musso, Giusto Viglino. Nephrology, S. Lazzaro Hospital, Alba, Cuneo, Italy

W465 HYPERHOMNOCYSTEINEMIA IN UNSUPPLEMENTED HAEMODIALYSIS PATIENTS Emil Andreev,1 Anna Tzontcheva,2 Diana Yonova,3 Lilyana Kambova,3 Boryana Kiperova.1 1Clin.of Nephrology, 2Dept of Clinical Laboratory, 3Dept of Hemodialysis, Medical Univ.-Sofia, Sofia, Bulgaria

419 WEDNESDAY, JUNE 12 POSTERS

W466 HOMOCYSTEINE, MTHFR GENOTYPE, VITAMIN B12 AND FOLATE IN HAEMODIALYSIS PATIENTS Claudio Cortese,1 Sandro De Angelis,2 Tiziana Tullio,2 Maria Rita Dessi,1 Stefania Casciani,1 Anna Pastore,3 L. Liberatoscioli,1 Giorgio Federici,1 Agostino Vega,2 Giorgio Splendiani.2 1Biochemical Chemistry, Univ. Hosp. “Tor Vergata”Rome, Italy; 2Nephrology and Dialysis Service, Univ. Hosp. “Tor Vergata”Rome, Italy; 3Pediatric, Hospital “Bambin Gesù”Rome, Italy

W467 HYPERHOMOCYSTEINAEMIA THERAPY IN HAEMODIALYSIS PATIENTS WITH COMBINATION OF VITAMIN B6, B12 AND FOLIC ACID Mohammad Reza Ardalan,1 Jalal Etemadi,1 Majid Mortazavi,1 Jafar Majidi.2 1Nephrology Dept, Imam Hospital, Tabriz, Iran; 2Immunology Dept, Imam Hospital, Tabriz, Iran

W468 THE LONG-TERM EFFECTIVENESS AND SAFETY OF FOLINIC ACID TREATMENT OF HYPERHOMOCYSTEINEMIA IN HAEMODIALYSIS PATIENTS: A TWO-YEAR EXPERIENCE Giorgia Bagiatoudi,1 Danai Stavrianaki,1 Konstantinos Salpigidis,1 Margarita Menexidou,2 Evangelos Sarris,1 Andreas Papanastassiou,2 Evmorfia Sagana,2 Marios Siakotos.1 1Dept of Nephrology, Western Attica General Hospital, Athens, Greece; 2Biochemistry Laboratory, Western Attica General Hospital, Athens, Greece

W469 INVERSE ASSOCIATION BETWEEN HOMOCYSTEINE AND VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 SERUM LEVELS IN HAEMODIALYZED AND KIDNEY TRANSPLANTED PATIENTS Vincenzo Sepe, Carmelo Libetta, Natalia Rossi, Cristina Guidetti, Antonio Dal Canton. Nephrology, Dialysis and Transplantation, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy

W470 EFFECT OF LOW DOSE FOLIC ACID THERAPY ON SULPHUR- CONTAINING AMINO ACIDS PROFILE IN CHRONIC RENAL FAILURE PATIENTS AND RENAL TRANSPLANT RECIPIENTS Mahmud Abuauba, Ryszard Grenda. 1Department of Nephrology and Kidney Transplantation, The Children’s Memorial Health Institute, Warsaw, Poland; 2Department of Nephrology and Kidney Transplanatation, The Children’s Memorial Health Institute, Warsaw, Poland

W471 CHRONIC FOLIC ACID SUPPLEMENTATION FAILED TO NORMALIZE PLASMA HOMOCYSTEINE LEVEL OR DECREASE THE INCIDENCE OF CARDIOVASCULAR EVENTS IN HAEMODIALYSIS PATIENTS Hirofumi Ikeda,1 Michiya Shinozaki,1 Michiaki Kubo,1 Masanori Tokumoto,1 Makoto Hirakawa,1 Kiichiro Fujisaki,1 Rei Matsui,1 Dai Matsuo,1 Kazuhiko Tsuruya,1 Kyoichi Fukuda,1 Hidetoshi Kanai,1 Hideki Hirakata,1 Satoru Fujimi.2 1Dept of Med and Clin Scie,Graduate School of Med Scie, Kyushu Univ, Fukuoka, Japan; 2Fukuoka Jinzo-Naika Clinic, Fukuoka, Japan

W472 PLASMA TOTAL HOMOCYSTEINE (tHcy) AND CYSTEINE (tCys) ARE RELATED TO THE OTHER PLASMA FREE AMINO ACIDS (AAs) Mohammed Suliman, Peter Stenvinkel, A. Rashid Qureshi, Olof Heimburger, Peter Barany, Bjorn Anderstam, Roberto Pecoits-Filho, Bengt Lindholm. Divisions of Renal Medicine and Baxter Novum, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden

420 POSTERS WEDNESDAY, JUNE 12

W473 CHANGES OF TOTAL HOMOCYSTEINE LEVELS BETWEEN THREE CONSECUTIVE DIALYSIS TREATMENTS IN DIALYSIS PATIENTS Apostolos Kyrgialanis,1 Efthemia Mourvati,1 Athanasia Agorasti,2 WEDNESDAY Ekaterini Martasidou,2 Despina Konstantinidou,2 Hristos Hatzidimitriou.1 1Renal Unit, General Hospital, Xanthi, Thrace, Greece; 2Laboratory of Hematology, General Hospital, Xanthi, Thrace, Greece

W474 SELECTIVE ADSORPTION OF HOMOCYSTEINE USING HFR-ON LINE TECHNIQUE Giorgio Splendiani,1 Sandro De Angelis,1 Tiziana Tullio,1 Agostino Vega,1 Maria Rita Dessì,2 Stefania Casciani,2 Rosalba Ruggia,2 Anna Pastore,3 Claudio Cortese.2 1Nephrology and Dialysis, Univ. Hospital “ Tor Vergata”Rome, Italy; 2Biochemical Chemistry, Univ. Hospital “Tor Vergata”Rome, Italy; 3Pediatric, Hospital “Bambino Gesù”Rome, Italy

W475 IS PLASMA HOMOCYSTEINE A CARDIOVASCULAR RISK FACTOR OR A NUTRITIONAL MARKER IN DIABETIC HAEMODIALYSIS PATIENTS? Kamyar Kalantar-Zadeh,1 Gladys Block,2 Joel D. Kopple.1 1Nephrology, Harbor-UCLA Med Center, Torrance, CA, United States; 2Epidemiology, UC Berkeley, Berkeley, CA, United States

W476 HYPERHOMOCYSTEINEMIA AND THE ADEQUACY OF STANDARD AND HDF ON-LINE HAEMODIALYSIS Maurizio Garozzo, Salvatore Urso, Filippo Milone, Giovanni Giorgio Battaglia. Unità Operativa di Nefrologia e Dialisi, AUSL 3 Catania - Ospedale S. Marta e S. Venera, Acireale, Catania, Italy

W477 METHYLENE-TETRAHYDROFOLATE-REDUCTASE GENE (C677T) POLYMORPHISM AS A RISK FACTOR FOR CARDIOVASCULAR DISEASE IN PATIENTS WITH NIDDM AND DIABETIC NEPHROPATHY Mike Stubanus,1 Carsten Boeger,1 Thomas Haak,2 Stephan R. Holmer,1 Michael Fischereder,1 Bernhard K. Krämer.1 1Nephrology, Klinik und Poliklinik Innere Medizin II, Universitiy of Regensburg, Regensburg, Germany; 2Diabeteszentrum, Bad Mergentheim, Germany

W478 METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) GENE POLYMORPHISM INFLUENCES THE EFFICACY OF FOLIC ACID (FA) AND VITAMIN B12 (B12) ON HYPERHOMOCYSTEINEMIA IN HaEMODIALYSIS (HD) PATIENTS Takamichi Nakamura,1 Hideo Hirayama,2 Munemasa Tajiri,3 Katsu Saionji,4 Akira Hata.5 1Division of Nephrology & Hypertension, Kumamoto City Hospital, Kumamoto, Japan; 2Hirayama Urology Clinic, Kumamoto, Japan; 3Kumamoto Daiichi Clinic, Kumamoto, Japan; 4Division of Laboratory Medicine, Self Defense Medical Collage, Tokorozawa, Saitama, Japan; 5Department of Public Health, Chiba University Medical School, Chiba, Japan

W479 REDUCED FOLATES HAVE AN ANTI-INFLAMMATORY EFFECT IN HAEMODIALYSIS PATIENTS Thomas Mueller,1 Nicole Mueller,2 Rudolf Moser,3 Thomas Stief,4 Daria Celle,2 Klaus Pietrizk.5 1Medicine, Renal Division, Brigham and Women’s Hospital, Boston, MA, United States; 2Medicine, Renal Division, Philipps-University, Marburg, Germany; 3Research and Development, Merck Eprova AG, Schaffhausen, Switzerland; 4Laboratory Medicine, Philipps- University, Marburg, Germany; 5Nutritional Sciences, University of Bonn, Bonn, Germany

421 WEDNESDAY, JUNE 12 POSTERS

W480 THE EFFECTS OF THE COMBINATION OF HOMOCYSTEINE AND CARDIAC TROPONION I ON ISCHEMIC HEART DISEASE WITH END STAGE RENAL DISEASE Jong Hoon Chung, Byung Chul Shin, Bum Yun Kim, Bong Kwan Ryu, Hyun Lee Kim. Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, Korea

W481 A DIFFICULT BALANCE: THE SAFETY AND EFFICACY OF FOLATE SUPPLEMENTATION TO TREAT HYPERHOMOCYSTEINEMIA (HYPERHOMO) IN DIALYSIS PATIENTS Daniela Bergamo,1 Manuel Burdese,1 Paola Massarenti,2 Daniela Pauletto,2 Fabrizio Fop,1 Alessandra Thea,1 Caterina Canavese.1 1Chair of Nephrology, University of Turin, Turin, Italy; 2Laboratory of Clinical Nutrition, San Giovanni Battista Hospital, Turin, Italy

W482 ORAL ADMINISTRATION OF BIFIDOBACTERIA IN GASTRO- RESISTANT SEAMLESS CAPSULE DECREASES SERUM LEVELS OF HOMOCYSTEIN IN HAEMODIALYSIS PATIENTS Fumio Takayama, Kentaro Taki, Mayumi Ikeda, Atsushi Enomoto, Isao Aoyama, Sakurako Nakamura, Toshimitsu Niwa. Department of Clinical Preventive Medicine, Nagoya University Hospital, Nagoya, Aichi, Japan

W483 SERUM COBALT (Co) AND NICKEL (Ni) LEVELS AND HYPERHOMOSYSTEINAEMIA (HHC) IN HAEMODIALYSIS PATIENTS (HD) Istvan Karpati,1 Jozsef Balla,1 Janos Matyus,1 Janos Dombovari,2 Laszlo Ujhelyi,1 Thomas Ben,1 Lajos Papp,2 Zsuzsa Varga,1 Gyorgy Kakuk.1 1First Department of Medicine, Medical and Health Science Center University of Debrecen, Debrecen, Hungary; 2Department of Analytical and Inorganic Chemistry, University of Debrecen, Debrecen, Hungary

422 POSTERS WEDNESDAY, JUNE 12

CARDIOVASCULAR RISK IN ESRD, CARDIAC HYPERTROPHY AND ATHEROSCLEROSIS WEDNESDAY

W484 THE EFFECT OF ULTRAPURE DIALYSATE ON AHSG/FETUIN LEVELS IN HAEMODIALYSIS PATIENTS Ralf Westenfeld,1,2 Anne Koll,1 Willi Jahnen-Dechent,2 Jürgen Floege,1 Markus Ketteler.1 1Nephrology, Univ. Hospital Aachen, Aachen, NRW, Germany; 2IZKF BioMAT, Univ. Hospital Aachen, Aachen, NRW, Germany

W485 A STRONG ASSOCIATION BETWEEN CORONARY ARTERY CALCIFICATION AND AORTIC PULSE WAVE VELOCITY IN ADULT DIALYSIS AND TRANSPLANT PATIENTS David Goldsmith,1 Helen Colhoun,2 Michael Rubens.3 1Renal Medicine and Transplantation, Guy’s Hosp., London, UK; 2Public Health and Epidemiology, Univ. College, London, UK; 3Imatron CT Scanning, Royal Brompton Hosp., London, UK

W486 SIMPLE VASCULAR CALCIFICATION SCORE - A SIMPLE PREDICTOR OF CARDIOVASCULAR DISEASE IN HAEMODIALYSIS PATIENTS Teresa Adragao, Ana Pires, Carlos Lucas, Rita Birne, Luis Magalhaes, Margarida Gonçalves, Acacio Pita Negrao. Hemodialysis, Nefroclínica, Estoril, Portugal

W487 PULSE WAVE VELOCITY CORRELATES WITH SIMPLE VASCULAR CALCIFICATION SCORE IN HAEMODIALYSIS PATIENTS Teresa Adragao, Ana Pires, Carlos Lucas, Rita Birne, Luis Magalhaes, Margarida Gonçalves, Acacio Pita Negrao. Hemodialysis, Nefroclínica, Estoril, Portugal

W488 EFFECTIVE ARTERIAL ELASTANCE AS A PREDICTOR OF CARDIOVASCULAR MORTALITY IN PATIENTS WITH END- STAGE RENAL FAILURE Wen-Chung Yu,1 Yao-Ping Lin,2 Chen-Huan Chen,1 Yu-An Ding,1 Wu-Chang Yang.2 1Section of Cardiology, Dept of Internal Medicine, Taipei-Veterans General Hospital, Taipei, Taiwan; 2Section of Nephrology, Dept of Internal Medicine, Taipei-Veterans General Hospital, Taipei, Taiwan

W489 CALCIUM, PHOSPHATE AND PARATHYROID HORMONE: IMPACT ON SURVIVAL, MORE THAN JUST HIGH PHOSPHATE Lesley A. Stevens, Ognjenka Djurdjev, E.C. Cameron, Adeera Levin. Nephrology, University of British Columbia, Vancouver, BC, Canada

W490 ANALYSES OF CORONARY ARTERY CALCIFICATION USING ELECTRON BEAM COMPUTED TOMOGRAPHY (EBCT)AMONG JAPANESE HAEMODIALYSIS PATIENTS Yoshinari Yasuda,1 Yoshinari Tsuruta,2 Yukio Narita,2 Takaaki Ohbayashi,3 Hisanori Azekura,3 Junko Yamazaki,3 Shigeru Nakai,1 Yoshiyuki Hiki,1 Kenji Maeda.1 1Department of In-Home Medicine, Nagoya University School of Medicine, Nagoya, Aichi, Japan; 2Nephrology Div., Meiyo Clinic Hemodialysis Center, Toyohashi, Aichi, Japan; 3Nephrology Div., Narita Memorial Hospital, Toyohashi, Aichi, Japan

423 WEDNESDAY, JUNE 12 POSTERS

W491 CARDIAC VALVE CALCIFICATIONS, LEFT VENTRICULAR HYPERTROPHY (LVH) AND CARDIOVASCULAR MORTALITY IN PATIENTS WITH END STAGE RENAL DISEASE (ESRD) Vincenzo Panuccio,1 Rocco Tripepi,1 Giovanni Tripepi,1 Francesca Mallamaci,1 Francesco A. Benedetto,1 Alessandro Cataliotti,2 Ignazio Bellanuova,2 Lorenzo Malatino,2 Carmine Zoccali.1 1Institute of Biomedicine, CNR, Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Reggio Calabria, Italy; 2Institute of Internal Medicine, Catania University, Catania, Italy

W492 QUANTIFYING THE IMPLICATIONS OF CORONARY CALCIFICATION FOR CARDIOVASCULAR RISK IN PATIENTS ON HAEMODIALYSIS J. Jaime Caro,1,2 Krista F. Huybrechts,1 Gérard M. London.3 1Medicine, Caro Research Institute, Concord, MA, United States; 2Epidemiology and Biostatistics, McGill University, Montreal, QC, Canada; 3Service d’Hémodialyse, Centre Hospitalier F.H Manhès, Fleury-Mérogis, France

W493 IS CARDIAC VALVE CALCIFICATION A MARKER OF ATHEROSCLEROSIS AND ARTERIAL CALCIFICATIONS IN END- STAGE RENAL DISEASE (ESRD) PATIENTS? Angela Yee-Moon Wang,1 Stella Sin-Yee Ho,2 Mei Wang,1 Jean Woo,3 Philip Kam-Tao Li,1 Siu-Fai Lui,1 Con Metreweli,2 John Sanderson.1 1Medicine & Therapeutics, 2Diagnostic & Interventional Radiology, 3Center for Nutritional Studies, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong

W494 ABDOMINAL AORTIC CALCIFICATION INDEX AND PULSE WAVE VELOCITY IN HEMODIALYSIS PATIENTS Masashi Kubo, Kiichiro Tago. Urology, Tago Kidney and Urology Clinic, Showa, Yamanashi, Japan

W495 CORONARY CALCIFICATIONS IN ASYMPTOMATIC HAEMODIALYSIS PATIENTS WITH THE USE OF SPIRAL COMPUTED TOMOGRAPHY (CT) S. Spaia,1 S. Patsalas,1 C. Theodoroglou-Gazioti,2 N. Askepidis,1 I. Ioannidis,1 M. Pazarloglou,1 V. Liakopoulos,1 G. Vayonas.1 1Department of Nephrology, 2nd IKA Hospital, Thessaloniki, Greece; 2Department of Computed Tomography, 2nd IKA Hospital, Thessaloniki, Greece

W496 ANALYSIS OF ATHEROSCLEROSIS BY PULSE WAVE VELOSITY (PWV) IN HAEMODIALYSIS (HD) PATIENTS- ONE YEAR FOLLOW UP STUDY Eriko Kinugasa,1 Hiroaki Ogata,1 Hidetoshi Ito,1 Masahiro Nishihara,2 Kanji Shishido.2 1Department of Internal Medicine, Showa University Nothern Yokohama Hospital, Yokohama, Japan; 2Kawasaki Clinic, Kawasaki, Japan

W497 QUANTITATIVE ANALYSIS OF CORONARY ARTERY CALCIFICATION BY MULTI-SLICE SPIRAL CT IN UREMIC PATIENTS Ping Zhang, Jiang-hua Chen, Wen-han Pen, Reng-ding Wang. Nephrology Center, The First Affiliated Hospital,Zhejiang University, Hangzhou, Zhejiang, China

W498 USEFULNESS OF MULTISLICE CT FOR CORONARY CALCIUM SCORE MEASUREMENT IN CHRONIC URAEMIC DIALYSIS PATIENTS Tiziano Lusenti,1 Fausto Soliani,1 Pierpaolo Borgatti,1 Giulio Tondelli,2 Antonio Troiso.2 1II Medicine, O.U. Nephrology and Dialysis, Reggio Emilia, Italy; 2Diagnostic Imaging, O.U. Radiology, Reggio Emilia, Italy

424 POSTERS WEDNESDAY, JUNE 12

W499 THE EFFECTS OF LOW CALCIUM DIALYSATE ON ARTERIAL COMPLIANCE AND VASOACTIVE SUBSTANCES IN PATIENTS WITH HAEMODIALYSIS Dongjin Oh, Soojeong Yoo, Jaeyoung Choi, Eungtaek Kang, Sukhee WEDNESDAY Yoo. Department of Internal Medicine, Phildong Hospital, College of Medicine, Chung-Ang University, Seoul, Republic of Korea

W500 AORTIC CALCIFICATIONS EVALUATED BY PLAIN ABDOMEN X-RAY PREDICT MORTALITY IN HAEMODIALYSIS PATIENTS Pietro Claudio Dattolo,1 Giuseppe Ferro,1 Umberto Maggiore,2 Quirino Maggiore,1 Francesco Pizzarelli.1 1Nephrology and Dialysis Unit, S.M.Annunziata Hospital, Florence, Italy; 2Clinica Medica and Nephrology, Univ.of Parma, Parma, Italy

W501 CORONARY CALCIFICATIONS AT INITIATION OF RENAL REPLACEMENT THERAPY ARE FOUND IN ONLY ONE THIRD OF PATIENTS Sylvia Rosas,1 Katharine Schankel,1 Mary Leonard,2 Daniel Rader.1 1Medicine, University of Pennsylvania, Philadelphia, PA, United States; 2Pediatrics, University of Pennsylvania, Philadelphia, PA, United States

W502 RISK FACTORS FOR CORONARY ARTERY DISEASE IN CHRONIC HAEMODIALYSIS PATIENTS Lygeri Soubassi,1 Dimitrios Chaniotis,2 Sofia Soubassi,1 Stylianos Zerefos,2 Angeliki Sarandakou,3 Pavlos Soubassis,2 Nicholaos Zerefos.2 1Dpt. of Nephrology, “Alexandra” Hospital, Athens, Greece; 2Dpt. of Clinical Therapeutics, “Alexandra” Hospital, Univ. of Athens, Athens, Greece; 3Hormone Laboratory, “Aretaieion” Hospital, Univ. of Athens, Athens, Greece

W503 OUTCOME AFTER CORONARY ARTERY BYPASS GRAFTING IN DIALYSIS PATIENTS Joachim Sirch, Michael Weyand, Guenter Fenchel, Steffen Pfeiffer. Center of Cardiac Surgery Erlangen-Nuernberg, Klinikum Nuernberg, Nuernberg, Germany

W504 SIGNIFICANTLY HIGHER MONOCYTIC ACE SURFACE EXPRESSION IN HAEMODIALYSIS PATIENTS WITH CORONARY (CAD) AND/OR PERIPHERAL ARTERY DISEASE (PAD) Christof Ulrich, Patric Garcia, Gunnar Heine, Urban Sester, Martina Sester, Hans Köhler, Matthias Girndt. Dep. of Nephrology, University of Homburg/Saar, Homburg, Germany

W505 QUANTIFICATION OF PERIPHERAL VASCULAR DISEASE IN PATIENTS WITH END-STAGE RENAL DISEASE: A FOLLOW-UP PROSPECTIVE STUDY Rita Sakova, Sylvie Sulkova, Oskar Zakiyanov. Department of Medicin, Strahov, Charles University, Prague, Czech Republic

W506 PERIPHERAL ARTERIAL DISEASE AS AN UNDERESTIMATED CAUSE OF DEATH IN HAEMODIALYSIS PATIENTS Michael Koch, Rudolf Trapp, Wolfgang Kulas. Nephrology, Nephrologisches Zentrum, Mettmann, Germany

W507 ARTERIOSCLEROSIS OBLITERANS IN MAINTENANCE HAEMODIALYSIS PATIENTS WITH DIABETES MELLITUS: CLINICAL OUTCOME OF CARDIOVASCULAR COMPLICATION AND LIFE PROGNOSIS Takashi Yokoyama, Yasuhiro Onodera, Tsutomu Mano. Department of Nephrology, Sapporo Tokushukai Hospital, Sapporo, Hokkaido, Japan

425 WEDNESDAY, JUNE 12 POSTERS

W508 PROGNOSTIC VALUE OF MYOCARDIAL PERFUSION IMAGING WITH ATP AFTER STARTING HAEMODIALYSIS IN PATIENTS WITH END-STAGE RENAL DISEASE Hiroki Hase,1 Nobuhiko Joki,2 Hiroyasu Ishikawa,1 Yoshihiko Imamura,2 Yuri Tanaka,1 Tomokatsu Saijyo,1 Yasunori Takahashi,1 Yoji Inishi,1 Masao Moroi.3 1Nephrology, Toho University Ohashi Hospital, Tokyo, Japan; 2Dialysis Center, Nissan Tamagawa Hospital, Tokyo, Japan; 3Cardiology, Toho University Ohashi Hospital, Tokyo, Japan

W509 USEFULNESS OF REDUCED UPTAKE OF IODINATED FATTY ACID ANALOGUE FOR DETECTION OF CORONARY ARTERY DISEASE AND PREDICTION OF CARDIAC EVENTS IN MAINTENANCE HAEMODIALYSIS PATIENTS Masato Nishimura,1 Tetsuya Hashimoto,2 Hiroyuki Kobayashi,2 Toyofumi Fukuda,2 Koji Okino,3 Noriyuki Yamamoto,2 Naoto Inoue,4 Toshihiko Ono.2 1Cardiovascular Division, Toujinkai Hospital, Kyoto, Japan; 2Division of Urology, Toujinkai Hospital, Kyoto, Japan; 3Division of Surgery, Toujinkai Hospital, Kyoto, Japan; 4Department of Cardiovascular Diseases, Kyoto Second Red Cross Hospital, Kyoto, Japan

W510 A SUCCESSFULLY TREATMENT OF ISCHEMIC HEART DISEASE IN PATIENTS WITH HAEMODIALYSIS (HD) USING ROTABLATOR – A COMPARISON OF RESTENOTIC RATE BETWEEN PATIENTS WITH AND WITHOUT HD Hidekazu Moriya, Kousuke Negishi, Kuniko Aso, Takayasu Ohtake, Shuzo Kobayshi. Department of Nephrology and Kidney & Dialysis Center, Shonan Kamakura General Hospital, Yamazaki Kamakura, Kanagawa, Japan

W511 ALTERATIONS IN CALCIUM AND PHOSPHATE METABOLISM ARE ASSOCIATED WITH THE EXTENT OF CARDIOVASCULAR DAMAGE IN HAEMODIALYSIS PATIENTS Carlo Massimetti,1 Carlo Ficaccio,5 Sabina Ficili,2 Daniele Pontillo,2 Franco Brescia,3 Maria Teresa Muratore,4 Paolo Midi,6 Matteo Maurizio Mauro,5 Enzo Ancarani.1 1Nephrology & Dialysis, Belcolle Hospital, Viterbo, Italy; 2Cardiology, Belcolle Hospital, Viterbo, Italy; 3Radiology, Belcolle Hospital, Viterbo, Italy; 4Chemistry, Belcolle Hospital, Viterbo, Italy; 5Nephrology & Dialysis, P.O. Albano, ASL Rome H, Albano, Roma, Italy; 6Cardiology, P.O. Albano, ASL Rome H, Albano, Roma, Italy

W512 HAEMODYNAMIC AND HUMORAL CHANGES ON HYPOTENSIVE AND NORMOTENSIVE PATIENTS UNDERGOING HAEMODIALYSIS Elisabet Coll, Maria Larrousse, Alex De la Sierra, Jose Lopez-Pedret, Aleix Cases. 1Nephrology Unit, Hospital Clinic, Barcelona, Spain; 2Hypertension Unit, Hospital Clinic, Barcelona, Spain; 3Hypertension Unit, Hospital Clinic, Barcelona, Spain; 4Nephrology Unit, Hospital Clinic, Barcelona, Spain; 5Nephrology Unit, Hospital Clinic, Barcelona, Spain

W513 INTRA-DIALYTIC HYPOTENSION AND ORTHOSTATIC HYPOTENSION AFTER DIALYSIS ARE SIGNIFICANT AND INDEPENDENT FACTORS AFFECTING MORTALITY IN HAEMODIALYSIS (HD) PATIENTS Yoshiharu Tsubakihara,1 Tatsuya Shoji,1 Masamitsu Fujii,2 Enyu Imai.3 1Department of Nephrology, Osaka Prefectural Hospital, Osaka, Japan; 2Department of Nephrology, Osaka Kose-Nenkin Hospital, Osaka, Japan; 3Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Suita, Osaka, Japan

426 POSTERS WEDNESDAY, JUNE 12

W514 LOW AND DROPPING BLOOD PRESSURE CORRELATES WITH HIGHER MORTALITY RISK IN HAEMODIALYSIS PATIENTS Robert Wolfe,1 Keith McCullough,2 Tadao Akizawa,3 Fumiaki Marumo,4 Kiyoshi Kurokawa,5 Bernard Canaud,6 Volker WEDNESDAY Wizemann,7 Juergen Bommer,8 Friedrich Port,2 Marcia Keen,10 Nathan Levin.9 1Biostatistics/KECC, University of Michigan, Ann Arbor, MI, United States; 2DOPPS, URREA, Ann Arbor, MI, United States; 3Medicine, Wakayama Medical University, Wakayama, Japan; 4Medicine, Tokyo Women’s Medical University, Tokyo, Japan; 5Medicine, Tokai University, Kanagawa, Japan; 6Nephrology, Lapeyronie University Hospital, Montpellier, France; 7Nephrology, Georg Haas Dialysezentrum, Giessen, Germany; 8Nephrology, University of Heidelberg, Heidelberg, Germany; 9Research, RRI, New York, NY, United States; 10Nephrology Medical Operations, Amgen, Thousand Oaks, CA, United States;

W515 EFFECTS OF BLOOD PRESSURE LOWERING AND ANTIHYPERTENSIVE DRUG CLASS ON CARDIOVASCULAR EVENTS OF HEMODIALYSIS PATIENTS RESULTS FROM HAEMODIALYSIS ANGIOTENSIN-INHIBITION RESCUE TRIAL (HEART) Naoyuki Nakao,1,2 Usami Takeshi,1 Toshida Atsushi,1 Masayuki Takada,2 Genjiro Kimura.1 1Department of Internal Medicien and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan; 2Div. of Nephrology, Gen Gen-Do Kimitsu Hospital, Kimitsu, Chiba, Japan

427 WEDNESDAY, JUNE 12 POSTERS

CARDIOVASCULAR MORBIDITY AND MORTALITY; LIPIDS, INFLAMMATION AND OTHER PREDICTORS

W516 LOW-DENSITY LIPOPROTEIN (LDL)-APHERESIS IMPROVES ARTERIOSCLEROSIS OBLITERANS (ASO) IN PATIENTS WITH HD THROUGH AN INCREASE IN VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND INSULIN-LIKE GROWTH FACTOR-I (IGF-I) Shuzo Kobayashi, Kousuke Negishi, Hidekazu Moriya, Kuniko Aso, Takayasu Ohtake. Department of Nephrology & Kidney Dialysis Center, Shonan Kamakura General Hospital, Kamakura, Kanagawa, Japan

W517 THE ANTI-INFLAMMATORY EFFECTS OF ATORVASTATIN IN HAEMODIALYSIS PATIENTS I. Chouliaras,1 G. Dimitriadis,1 E. Economou,2 P. Dagounaki,3 L. Sinodinos,1 G. Koutroubas,1 Chr Christodoulidou,1 N. Nikolopoulou,1 V. Hadjiconstantinou.1 1Renal, Evangelismos Hospital, Athens, Attika, Greece; 2University Cardiology, Hippokration Hospital, Athens, Attika, Greece; 3Renal Unit, Lefkos Stavros Clinic, Athens, Attika, Greece

W518 ATORVASTATIN REDUCES PREVALENCE OF SMALL DENSE LOW DENSITY LIPOPROTEIN AND REMNANT-LIKE LIPOPROTEIN PARTICLES-CHOLESTEROL LEVELS IN HAEMODIALYSIS PATIENTS Takayasu Taira,1 Toru Hyodo,1 Toru Takemura,1 Natsuko Gushiken,1 Tetsuo Chiba,1 Hideo Hidai,1 Satoru Murayama,2 Ayako Ikejiri,2 Tsutomu Hirano.2 1Nephrology, Yokohama Dai-ichi Hospital, Yokohama, Kanagawa, Japan; 2First Dept of Internal Medicine, Showa Univ., Tokyo, Japan

W519 EFFECTS OF ATORVASTATIN (ATO) ON C-REACTIVE PROTEIN (CRP) LEVELS IN HAEMODIALYSIS PATIENTS (HDP): A PROSPECTIVE STUDY Luigi Vernaglione, Claudio Cristofano, Fabio Pennacchiotti, Pietro Muscogiuri, Stefano Chimienti. Nephrology and Dialysis Unit, “M. Giannuzzi” Hospital, Manduria, Taranto, Italy

W520 A STUDY TO EVALUATE THE USE OF ROSUVASTATIN IN SUBJECTS ON REGULAR HAEMODIALYSIS: AN ASSESSMENT OF SURVIVAL AND CARDIOVASCULAR EVENTS - THE AURORA STUDY Bengt Fellström,1 Faiez Zannad,2 Roland Schmieder,3 Hallvard Holdaas,4 Alan Jardine,5 Jon Armstrong,6 Annica Siewert-Delle.7 1Dept of Medical Science, Renal Unit, University Hospital, Uppsala, Sweden; 2CIC, Hôpital Jeanne d’Arc, Toul, France; 3Med Klinik IV, Univ.-Klinik Erlangen-Nürnberg, Nürnberg, Germany; 4Dept of Nephrology, Rikshospitalet, Oslo, Norway; 5Dept of Medicine and Therapeutics, Western Infirmary Hospital, Glasgow, United Kingdom; 6AstraZeneca, Macclesfield, United Kingdom; 7AstraZeneca, Mölndal, Sweden

W521 URAEMIC DISLIPIDAEMIA PREDICTS ALL-CAUSE DEATH IN CHRONIC HAEMODIALYSIS PATIENTS Norberto Tavella,1 Carlos E. Romero,1 Asuncion Alvarez,2 Jose E. Ventura.2 1Cardiologia, Hospital de Clinicas, Universidad de la Republica, Montevideo, Uruguay; 2Servicio Asistencia Renal Integral, Montevideo, Uruguay

428 POSTERS WEDNESDAY, JUNE 12

W522 EFFECTS OF BIFIDOBACTERIA IN GASTRO-RESISTANT SEAMLESS CAPSULE ON SERUM LEVELS OF LIPIDS IN HAEMODIALYSIS PATIENTS Kentaro Taki, Fumio Takayama, Mayumi Ikeda, Atsushi Enomoto, WEDNESDAY Isao Aoyama, Sakurako Nakamura, Toshimitsu Niwa. Department of Clinical Preventive Medicine, Nagoya University Hospital, Nagoya-city, Aichi, Japan

W523 SERUM URIC ACID LEVEL IS ASSOCIATED WITH ALL-CAUSE MORTALITY IN HAEMODIALYSIS PATIENTS — AN “U-SHAPED” RELATIONSHIP Shih-Ping Hsu, Kuan-Yu Hung, Mei-Fen Pai, Yu-Sen Peng. Department of Internal Medicine, Far Eastern Memorial Hospital, Panchiao, Taipei, Taiwan

W524 FACTORS AFFECTING MORTALITY IN END-STAGE RENAL FAILURE PATIENTS INITIATING HAEMODIALYSIS Olivera Stojceva-Taneva, Liljana Tozija, Gjulsen Selim, Risto Grozdanovski, Katica Zafirovska. Department of Nephrology, University “Sts.Cyril and Methodius”Skopje, Macedonia, F.Y.R.M.

W525 RISE IN CRP AND DROP OF Kt/V ARE MARKERS OF POUR PROGNOSIS IN PATIENTS ON CHRONIC HAEMODIALYSIS (CHD) Frank Merkel,1 Michael Boos,2 Michael Nebel,2 Manfred Weber.1 1Medizinische Klinik I, Klinikum Merheim, Cologne, Germany; 2KfH Dialysezentrum, Merheim, Cologne, Germany

W526 IMPROVED B-TYPE NATRIURETIC PEPTIDE (BNP) CONCENTRATIONS AFTER CARDIOVASCULAR TRAINING IN HYPERTENSIVE DIALYSIS-PATIENTS Emanuel Fritschka, Jarmila Mahlmeister. Nephrology, Sinntalklinik, Bad Brueckenau, Bayern, Germany

W527 PULSE PRESSURE AND BRAIN NATRIURETIC PEPTIDE ARE RELATED TO LEFT VENTRICULAR MASS IN PATIENTS UNDERGOING MAINTENANCE HAEMODIALYSIS Takeshi Kosugi, Kiyoko Matsuo, Yuko Shibuya, Toshio Ikeda, Tomoko Gomi. Nephrology, NTT Kanto Medical Center, Tokyo, Japan

W528 PLASMA ADIPONECTIN CONCENTRATION AND SURVIVAL OF HAEMODIALYSIS PATIENTS WITH END STAGE KIDNEY DISEASE (ESKD) Andrzej Wiecek,1 Witold Ignacy,1 Jerzy Chudek,1 Tohru Funahashi,2 Marcin Adamczak,1 Yuji Matsuzawa,2 Franciszek Kokot.1 1Dept. of Nephrology, Endocrinology and Metabolic Diseases, Silesian University School of Medicine, Katowice, Poland; 2Dept. of Internal Medicine and Molecular Medicine, Osaka University, Osaka, Japan

W529 THIRD GENERATION IMMUNOASSAY OF CARDIAC TROPONIN T DETECTS INCREASED LEVELS IN STABLE HAEMODIALYSIS BUT NOT IN PREDIALYSIS PATIENTS Ferdinand Rivera, Edmundo Jordan, Hector Cordova. Medical Service-Renal Section, Department of Veterans Affairs Medical Center, San Juan, Puerto Rico

W530 INCIDENCE OF ELEVATED LEVELS OF CARDIAC TROPONIN-I AND ITS PROGNOSTIC SIGNIFICANCE IN A DIALYSIS POPULATION Magdi Hussein,1 Jaap Mooij,1 Haysam Roujouleh,1 Omer Al Shenawi.2 1Department of Nephrology and Dialysis, Al Hada Hospital, Taif, Saudi Arabia; 2Laboratory Department, Al Hada Hospital, Taif, Saudi Arabia

429 WEDNESDAY, JUNE 12 POSTERS

W531 FACTORS ASSOCIATED WITH INCREASED SERUM LEVELS OF TROPONIN I IN HAEMODIALYZED PATIENTS WITHOUT EVIDENCE OF ACUTE CORONARY SYNDROMES Marek Muszytowski, Julia Popowska-Drojecka, Maria Wojnicz, Piotr Moczynski, Konrad Normantowicz, Hanna Brygiert-Jarzabek. Nephrology and Internal Medicine Department, District Hospital, Torun, Poland

W532 NEUROPEPTIDE Y (NPY), NOREPINEPHRINE AND INCIDENT CARDIOVASCULAR EVENTS IN END-STAGE RENAL DISEASE (ESRD) Carmine Zoccali,1 Francesca Mallamaci,1 Giovanni Tripepi,1 Saverio Parlongo,1 Sebastiano Cutrupi,1 Graziella Bonanno,2 Francesco Rapisarda,2 Pasquale Fatuzzo,2 Giuseppe Seminara,2 Alessandro Cataliotti,2 Lorenzo Malatino.2 1Institute of Biomedicine, CNR, Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Reggio Calabria, Italy; 2Institute of Internal Medicine, Catania University, Catania, Italy

W533 INFLAMMATION PROCESS MAY INFLUENCE DISPERSION PARAMETERS OF THE MYOCARDIUM REPOLARIZATION PHASE IN HAEMODIALYSED PATIENTS Andrzej Jaroszynski, Andrzej Ksiazek. Clinic and Department of Nephrology, Medical University of Lublin, Lublin, Poland

W534 CLINICAL SIGNIFICANCE OF SERUM MACROPHAGE COLONY STIMULATING FACTOR (MCSF) AND MACROPHAGE CHEMOATTRACTANT PROTEIN (MCP) -1 IN HAEMODIALYSIS PATIENTS Kazutaka Haraguchi,1 Masashi Kubo,2 Kiichiro Tago,2 Takehiro Saitoh,1 Mitsuhiko Takahashi,1 Hiroki Shimura,1 Tetsuro Kobayashi.1 1The 3rd Department of Internal Medicine, University of Yamanashi, Nakakoma, Yamanashi, Japan; 2Tago Kidney & Urology Clinic, Showa, Yamanashi, Japan

W535 RELAXIN IS AN INDEPENDENT RISK FACTOR PREDICTING MORTALITY IN PATIENTS WITH END-STAGE KIDNEY DISEASE Berthold Hocher,1 Reinhard Ziebig,2 Rolfdieter Krause,3 Gernot Asmus,4 Hans-H. Neumayer,1 Johannes-Peter Stasch.5 1Nephrology, University Hospital CharitéBerlin, Germany; 2Laboratory Medicine, University Hospital CharitéBerlin, Germany; 3Dialysezentrum-Moabit, KfH, Berlin, Germany; 4Dialysezentrum Sonnenallee, KfH, Berlin, Gabon; 5Institute of Cardiovascular Research, Bayer AG, Wuppertal, NRW, Germany

W536 THE INFLUENCE OF SMOKING IN ATHEROGENESIS OF HAEMODIALYSIS PATIENTS Lygeri Soubassi,1 Dimitrios Chaniotis,2 Sofia Soubassi,1 Stylianos Zerefos,2 Angeliki Sarandakou,3 Pavlos Soubassis,2 Nicholaos Zerefos.2 1Dpt. of Nephrology, “Alexandra” Hospital, Athens, Greece; 2Dpt. of Clinical Therapeutics, “Alexandra” Hospital, Univ. of Athens, Athens, Greece; 3Hormone Laboratory, “Aretaieion” Hospital, Univ. of Athens, Athens, Greece

W537 MATRIX METALLOPROTEINASE 3 INCREASES IN THE LONG TERM DIABETIC HAEMODIALYSIS PATIENTS Toshio Arakawa,1 Takeo Goto,2 Naoya Igaki,2 Masafumi Fukagawa.3 1Internal Medicine, Arakawa Renal Clinic, Takasago, Hyogo, Japan; 2Internal Medicine, Takasago Municipal Hospital, Takasago, Hyogo, Japan; 3Renal Division and Dialysis Unit, Kobe University School of Medicine, Kobe, Hyogo, Japan

430 POSTERS WEDNESDAY, JUNE 12

W538 CRP AS A PREDICTOR OF CARDIOVASCULAR DISEASE AND ITS STABILITY IN PATIENTS ON MAINTENANCE HAEMODIALYSIS Li Zuo, Mei Wang, Hui Du, Li Yang. Renal Division, Dept of Medicine, First Hosp., Peking Univ., Beijing, China WEDNESDAY

W539 ASSOCIATION OF HAPTOGLOBIN PHENOTYPE AND MORTALITY IN HAEMODIALYSIS PATIENTS Zvi Burbea,1 Farid Nahkoul,1 Karl Skorecki,1 Roaa Zoabi,1 Irit Hochberg,1 Sidney BenChetrit,2 David Tovbin,3 Aaron Knecht,2 Adrian Iaina,2 Joshua Weisgarten,2 Michal Herman,2 Batya Kristal,1 Andrew Levy.1 1Nephrology and Faculty of Medicine, Rambam Medical Center and Technion, Haifa, Israel; 2Sackler School of Medicine and, Tel Aviv University, Tel Aviv, Israel; 3School of Medicine, Ben-Gurion University, Beer Sheva, Israel

W540 VON WILLEBRAND FACTOR IS AN INDIPENDENT RISK MARKER FOR MAJOR IN-HOSPITAL CARDIOVASCULAR COMPLICATIONS IN HAEMODIALYSIS (HD) PATIENTS WITH ACUTE MYOCARDIAL INFRACTION Dimitris Xydakis,1 Apostolos Papadogiannakis,1 Maria Sfakianaki,2 Alkiviadis Dermitzakis,3 Konstantinos Papachristoforou.1 1Nephrology Department, 2 Second Internal Medicine Department, 3Cardiology Department, Venizeleio Hospital, Irakleio, Greece

W541 DECLINING SERUM ALBUMIN CONCENTRATION RESULTS FROM DECREASED ALBUMIN SYNTHESIS ASSOCIATED WITH THE ACUTE PHASE RESPONSE BUT NOT DECREASED nPCR IN HAEMODIALYSIS PATIENTS George A. Kaysen,1,2 Joel Dubin,3 Hans-Georg Müller,4 Laura Rosales,5 Nathan W. Levin,5 William E. Mitch,6 and the HEMO Group.7 1Research Service, VANCHCS, Mather, CA, United States; 2Medicine, UC Davis, Davis, CA, United States; 3Division of Biostatistics, Yale University, New Haven, CT, United States; 4Department of Statistics, UC Davis, Davis, CA, United States; 5Renal Research Institute, NY, NY, United States; 6Medicine, University of Texas, Galveston, TX, United States; 7NIDDK, Bethesda, MD, United States

W542 RELATIONSHIP BETWEEN MALNUTRITION, INFLAMMATION AND ATHEROSCLEROSIS IN PATIENTS ON CHRONIC HD Biserka Timenstajn,1 Nada Dimkovic,2 Jasmina Strajnic.1 1Center for Nephrology/Dialysis, Hospital Zajecar, Zajecar, Serbia, Yugoslavia; 2Center for Renal Diseases, Zvezdara University Hospital, Belgrade, Serbia, Yugoslavia

W543 CLINICAL CONSEQUENCES OF INTERMITTENT ELEVATION OF C-REACTIVE PROTEIN LEVEL IN HEMODIALYSIS PATIENTS Siren Sezer,1 Eyup Kulah,1 F. Nurhan Ozdemir,1 Emre Tutal,2 Zubeyde Arat,1 Mehmet Haberal.3 1Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey; 2Internal Medicine, Baskent University Faculty of Medicine, Ankara, Turkey; 3General Surgery, Baskent University Faculty of Medicine, Ankara, Turkey

W544 COMPARISON OF THREE AUTOMATED C-REACTIVE PROTEIN (CrP) METHODS IN END STAGE RENAL DISEASE (ESRD): CLINICAL AND EPIDEMIOLOGICAL IMPLICATIONS Ciro Tetta,1 Jean Paul Cristol,2 Bernard Canaud,2 Anne Marie Dupuy,2 Marco Formica,3 Vincenzo Panichi,4 Maria Luisa Metelli,4 Luisa Sereni,4 Concetta De Nitti,4 Umberto Maggiore.5 1FMC, Div Med, Bad Homburg, Germany; 2Nephrol/Biochem, Lapeyronie Univ Hosp, Montpellier, France; 3Nephrol& Dial, St Croce Hosp, Cuneo, Italy; 4Int Med, Univ Pisa, Pisa, Italy; 5Int Med, Univ Parma, Parma, Italy

431 WEDNESDAY, JUNE 12 POSTERS

W545 INFLAMMATION AND MICROINFLAMMATION IN HAEMODIALYSIS PATIENTS - A LONGITUDINAL STUDY George Tsirpanlis,1 Pantelis Bagos,2 Dimitris Ioannou,3 Aliki Bleta,3 Ioanna Marinou,4 Antonis Lagouranis,1 Anastasios Ioannidis,4 Stylianos Chatzipanagiotou,4 Chrysoula Nikolaou.4 1Renal Unit, Alexandra Gen Hosp, Athens, Greece; 2Cell Biology and Biophysics, Fac of Biology, Univ of Athens, Athens, Greece; 3Renal Unit, Dragini Clinic, Athens, Greece; 4Med Biopathology, Eginition Hosp, Med School, Univ of Athens, Athens, Greece

W546 EFFECT OF AN INCREASE IN CRP LEVEL DURING A HAEMODIALYSIS SESSION ON MORTALITY Johanna C. Korevaar,1 Jeannette G. van Manen,1 Friedo W. Dekker,2 Elisabeth W. Boeschoten,3 Raymond T. Krediet.4 1Dept. Clinical Epidemiology & Biostatisitcs, AMC, Amsterdam, Netherlands; 2Dept. Clinical Epidemiology, LUMC, Leiden, Netherlands; 3Dept Nephrology, Dianet-AMC, Amsterdam, Netherlands; 4Dept. Nephrology, AMC, Amsterdam, Netherlands

W547 VARIABILITY CHARACTERISTICS AND ACCURATE ESTIMATION OF THE MICROINFLAMMATION IN HAEMODIALYSIS PATIENTS George Tsirpanlis,1 Pantelis Bagos,2 Dimitris Ioannou,3 Aliki Bleta,3 Ioanna Marinou,4 Antonis Lagouranis,1 Anastasios Ioannidis,4 Stylianos Chatzipanagiotou,4 Chrysoula Nikolaou.4 1Renal Unit, Alexandra Gen Hosp, Athens, Greece; 2Cell Biology and Biophysics, Fac of Biology, Univ of Athens, Athens, Greece; 3Renal Unit, Dragini Clinic, Athens, Greece; 4Med Biopathology, Eginition Hospital, Med School, Univ of Athens, Athens, Greece W548 INCREASED ADHESION MOLECULES IN HAEMODIALYSIS PATIENTS: INTERACTION WITH CARDIOVASCULAR, INFLAMMATORY, NUTRITIONAL AND GENETIC FACTORS S. Kahraman, G. Genctoy, R. Yilmaz, M. Arici, B. Altun, S. Kirazli, Y. Erdem, U. Yasavul, C. Turgan, S. Caglar. Internal Medicine-Nephrology, Hacettepe Univ. Fac. of Med., Ankara, Turkey

W549 THE ANGIOTENSIN CONVERTING ENZYME INHIBITOR RAMIPRIL REDUCES SERUM CRP LEVELS IN HAEMODIALYSIS PATIENTS George Dimitriadis,1 Ioannis Chouliaras,1 Emanuel Economou,2 Paraskevi Dagounaki,3 George Tsagalis,1 Theofanis Apostolou,1 Vasilios Margelos,1 George Metaxatos,1 Valsamakis Hadjiconstantinou.1 1Renal Department, Evangelismos Hospital, Athens, Attica, Greece; 2University Cardiology, Hippokration Hospital, Athens, Attica, Greece; 3Renal Unit, Lefkos Stavros, Athens, Attica, Greece

W550 IMPROVED MYOCARDIAL FUNCTION, ASSESSED BY TISSUE DOPPLER VELOCITY IMAGING (TVI), FOLLOWING A SINGLE HAEMODIALYSIS (HD) SESSION Shirley Hayashi,1 Lars-Ake Brodin,2 Anders Alvestrand,1 Peter Stenvinkel,1 Marcelo Nascimento,1 Abdul Qureshi,1 Samir Saha,2 Britta Lind,2 Bengt Lindholm,1 Astrid Seeberger.1 1Renal Medicine and Baxter Novum, Department of Clinical Science,Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden; 2Department of Clinical Physiology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden W551 HOSPITAL ADMISSIONS (HOSP ADM) AND BED DAYS (BD) FOR ESRD CARDIOVASCULAR (CV) CO-MORBID CONDITIONS IN A DISEASE MANAGEMENT SETTING T.I. Steinman,1 A.R. Nissenson,2 J.P. Dickmeyer,2 W.D. Mattern,2 J. Nielsen,2 T.F. Parker,2 A.R. Hull.2 1Dept of Medicine, Renal Division, Beth Israel Deaconess Medical Center, Boston, MA, Usa; 2RMS Disease Management, McGaw Park, IL, USA

432 POSTERS WEDNESDAY, JUNE 12

W552 L-CARNITINE REDUCES SYSTOLIC BLOOD PRESSURE AND HYPERCHOLESTEROLEMIA IN HAEMODIALYSIS PATIENTS Ciro Esposito,1 Flavia Cornacchia,1 Andreana De Mauri,1 Gianluca Fasoli,1 Annalisa Foschi,1 Tiziana Mazzullo,1 Anna Rita Plati,1 WEDNESDAY Nicoletta Bellotti,1 Bambina Parrilla,1 Roberta Scudellaro,1 Fabrizio Grosjean,1 Luca Franco Lanzarini,2 Lucia Petrucci,3 Antonio Dal Canton.1 1Nephrology Dialysis Transplantation, University of Pavia IRCCS Policlinico S.Matteo, Pavia, Italy; 2U.O. of Cardiology, IRCCS Policlinico S.Matteo, Pavia, Italy; 3Physical Therapy, IRCCS Policlinico S.Matteo, Pavia, Italy

W553 THE EFFECTS OF SUPPLEMENTAL CARNITINE DIET ON CARDIOVASCULAR COMPLICATIONS OF PATIENTS ON CHRONIC DIALYSIS Hamid Tayebi Kh,1 Bohlul Habibi Asl,2 Mehrnoosh Toofan.3 1Department of Hemodialysis , Imam Hospital Tabriz – Iran, Tabriz University of Medical Scienses, Tabriz, Iran; 2Department of Hemodialysis , Imam Hospital, Tabriz University of Medical Scienses, Tabriz, Iran; 3Department of Hemodialysis , Imam Hospital, Tabriz University of Medical Scienses, Tabriz, Iran

W554 INSULIN RESISTANCE AS AN INDEPENDENT PREDICTOR OF MORTALITY IN PATIENTS ON CHRONIC HAEMODIALYSIS Efstathia Tziviskou, Constantina Kakaletri, Stavroula Ziakka, Filippos Karakasis, Nikolas Papagalanis. Nephrology Department, Red Cross Hospital, Athens, Attiki, Greece

W555 PATTERNS OF MORTALITY ON RENAL REPLACEMENT IN THE UK; DATA FROM UK RENAL REGISTRY Catherine Byrne,1 David Ansell,1 Paul Roderick,2 Kate Thomas,1 Terry Feest.1 1UK Renal Registry, Southmead Hospital, Bristol, Avon, United Kingdom; 2Department of Public Health, Southampton University, Southampton, Hampshire, United Kingdom

W556 INFLUENCE OF “ESSENTIAL” PHOSPHOLIPIDS ON LIPID PROFILE AND LIPID PEROXIDATION IN HAEMODIALYSIS PATIENTS Irena P. Pietrzak, Katarzyna M. Bladek. Department of Nephrology, University of Medical Sciences, Poznan, Poland

W557 THE EFFECTS OF EXERCISE TRAINING ON VARIABLES PREDISPOSING DIALYSIS PATIENTS TO CARDIAC DEATH Evangelia Kouidi,1 Dimitrios Grekas,2 Georgia Koukouvou,1 Erasmia Konstantinidou,1 John Kalevrosoglou,2 Asterios Deligiannis.1 1Laboratory of Sports Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece; 2A’ Internal Medicine Clinic, Aristotle University of Thessaloniki, Thessaloniki, Greece

W558 INTERLEUKIN 6 IS A STRONGER PREDICTOR OF TOTAL AND CARDIOVASCULAR MORTALITY THAN C-REACTIVE PROTEIN IN DIALYTIC PATIENTS Vincenzo Panichi,1 Umberto Maggiore,2 Daniele Taccola,1 Massimiliano Migliori,1 Giovanni Manca Rizza,1 Cristina Consani,1 Stefano Sposini,3 Giancarlo Betti,3 Rafael Perez,4 Paolo Rindi,5 Roberto Palla,3 Ciro Tetta.6 1Internal Medicine, University of Pisa, Pisa, Italy; 2Nephrology, University of Parma, Parma, Italy; 3Nephrology Division, Hospital Massa, Massa, Italy; 4Servicio de Nefrologia, Hospital G. Maranon, Madrid, Spain; 5Nephrology Division, Hospital Pisa, Pisa, Italy; 6Fresenius Medical Care, Germany

433 WEDNESDAY, JUNE 12 POSTERS

W559 RISK FACTORS PREDICTING MORTALITY OF PATIENTS WITH AND WITHOUT DIABETES ON CHRONIC HAEMODIALYSIS ARE DIFFERENT Berthold Hocher,1 Reinhard Ziebig,2 Claudia Altermann,2 Rolfdieter Krause,3 Gernot Asmus,4 Claus-Michael Richter,1 Torsten Slowinski,1 Pranav Sinha,2 Hans-H. Neumayer.1 1Nephrology, University Hospital CharitéBerlin, Germany; 2Laboratory Medicine, University Hospital CharitéBerlin, Germany; 3Dialysezentrum Moabit, KfH, Berlin, Germany; 4Dialysezentrum Sonnenallee, KfH, Berlin, Germany

W560 CERULOPLASMIN AND COPPER LEVELS ARE RELATED TO MORE CLASSICAL INFLAMMATION MARKERS IN CHRONIC DIALYTIC PATIENTS Vincenzo Panichi,1 Daniele Taccola,1 Massimiliano Migliori,2 Cristina Filippi,2 Manca Rizza Giovanni,1 Paoletti Sabrina,1 Consani Cristina,1 Casarosa Leonardo,1 Soldani Ilaria,1 Sidoti Antonino,3 Giovannini Luca.2 1Internal Medicine, University of Pisa, Pisa, Italy; 2Department of Neuroscience, University of Pisa, Pisa, Italy; 3Dialisis Unit, Hospital Poggibonsi, Poggibonsi, Italy

W561 BOTH, CRP AND NUMBER OF TEETH ARE ASSOCIATED WITH MORTALITY RISK IN CHRONIC HAEMODIALYSIS PATIENTS - A CASE FOR PERIODONTAL DISEASE AS RISK FACTOR FOR MORTALITY? Martin Kuhlmann,1 Michal Altschüler,2 Steffi Hässig,2 Elmar Reich,2 Hans Köhler.1 1Div. of Nephrology, Univers. of Saarland, Homburg/Saar, Germany; 2Dpt. of Dentistry, Univers. of Saarland, Homburg/Saar, Germany

W562 ANALYSIS OF SERUM CHOLESTEROL IN 2732 PREVALENT DIALYSIS PATIENTS DURING 1999 AND THEIR RELATIVE HAZARD OF DEATH IN 2000. DATA FROM THE UK REGISTRY Janice Harper,1 David Ansell,2 Dirk van Schalkwyk,2 Terry Feest.2 1Renal Unit, Liverpool Royal Infirmary, Liverpool, United Kingdom; 2UK Renal Registry, Southmead Hospital, Bristol, United Kingdom

W563 RENIN-ANGIOTENSIN SYSTEM BLOCKADE REDUCES MORTALITY IN CHRONIC HAEMODIALYSIS PATIENTS Koichi Asahi, Tetsuo Katoh, Tsuyoshi Watanabe. Department of Internal Medicine 3, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan

W563a THE EFFECTS OF FOSINOPRIL ON CARDIOVASCULAR MORBIDITY AND MORTALITY IN HAEMODIALYSIS PATIENTS. THE FOSIDIAL STUDY Faiez Zannad,1 Jean Pierre Grunfeld,2 Michele Kessler,1 Christian Thuilliez,3 the Fosidial Investigators.4 1Cardiology, Nephrology and Clinical Investigation Center, CHU Nancy University Henri Poincare, Vandoeuvre les Nancy, France; 2Nephrology, CHU Necker, University Paris V, Paris, France; 3Clinical Pharmacology, CHU Rouen, Rouen, France; 4Hemodialysis Centers, France

W564 THE ASSOCIATION OF ACETATE FREE BIOFILTRATION (AFB) AND AN69ST MEMBRANE LIMITS IN PATIENTS THE CELL AC- TIVATION POSSIBLY LEADING TO URAEMIC DIALYTIC VASCULOPATHY Alessandro Amore,1 Paola Cirina,1 Monica Chiesa,1 Alessandra Mollo,1 Domenico Mancuso,1 Alice Ravizza,1 Franco Bonello,2 Franca Giacchino,2 Rosanna Coppo.1 1Nephrology Dialysis Transplantation, Regina Margherita Chil- dren’s Hospital, Torino, Italy; 2Nephrology Dialysis, Ospedale Civ- ile, Ivrea, Italy

434 POSTERS WEDNESDAY, JUNE 12

W565 IS ASYMPTOMATIC PERICARDIAL EFFUSION A SIGN OF POOR LEFT VENTRICULAR SYSTOLIC FUNCTION OR INADECATE HAEMODIALYSIS, OR BOTH? Natasa Markovic,1 Nada Dimkovic,2 Mihajlo Zdravkovic,1 Zoran WEDNESDAY Paunic,3 Zoran Radojicic.4 1Cardiology, University Hospital Zvezdara, Belgrade, Serbia, Yu- goslavia; 2Nephrology, University Hospital Zvezdara, Belgrade, Serbia, Yugoslavia; 3Nephrology, Military Medical Academy, Bel- grade, Serbia, Yugoslavia; 4Statistic, Faculty for Organisation Sciencies, University of Belgrade, Belgrade, Serbia, Romania

W566 EARLY MORTALITY AS A MEASURE OF OUTCOME IN DIALY- SIS PATIENTS Salvatore Mandolfo,1 Pablo Cosci,1 Marco Farina,1 Fabio Malberti,1 Enrico Imbasciati.1 1Renal Unit, Ospedale Maggiore, Lodi, LO, Italy; 2Renal Unit, Istituti Ospedalieri, Cremona, CR, Italy

435 WEDNESDAY, JUNE 12 POSTERS

VASCULAR ACCESS

W567 CORRECTION OF SUBCLINICAL STENOSIS: RESULTS OF A FIVE- YEAR VASCULAR ACCESS SURVEILLANCE PROTOCOL Jose Maria Garrancho,1 Mariana Arranz,1 Daniele Marcelli,2 Victor Moscardo,2 Mihaly Tapolyai,2 Ramon Rentero.3 1Unidad de Hemodialisis FMC, Hospital General Mancha Centro, Alcazar de San Juan, Ciudad Real, Spain; 2Clinical Management Europe, Fresenius Medical Care, Bad Homburg, Germany; 3Clinical Management Europe, FMC, Madrid, Spain

W568 THE EFFECT OF SURVEILLANCE OF A-V GRAFT ON GRAFT SURVIVAL Toshiyuki Hiranaka, Tomoyuki Yamakawa, Masao Kimu. Surgery, Shirasagi Hospital, Osaka, Japan

W569 AN APPROACH TO THE EVALUATION OF THE VASCULAR ACCESS ON PATIENTS UNDER HAEMODIALYSIS. PLASMA C- REACTIVE PROTEIN AND BETA-2 MICROGLOBULIN AS PROGNOSTIC FACTORS Styliani Giannakaki, Maria Mylonopoulou, Sofia Kalogeropoulou, Gabriel Papadakis. Department of Nephrology, Tzanio General Hospital, Piraeus, Greece

W570 CROSS-OVER TRIAL COMPARING BLOOD FLOW (Qa) AND COLOR-DOPPLER ULTRASONOGRAPHY SURVEILLANCE FOLLOWED BY INTERVENTION IN HAEMODIALYSIS GRAFTS Giuseppe Bacchini,1 Alberto Magnasco,2 Antonio Cappello,3 Vincenzo La Milia,1 Francesco Locatelli,1 Pietro Pozzoni.1 1Nephrology and Dialysis, A. Manzoni Hospital, Lecco, Italy; 2Nephrology and Dialysis, S. Andrea Hospital, La Spezia, Italy; 3Radiology Department, A. Manzoni Hospital, Lecco, Italy

W571 VASCULAR ACCESS ASSESSMENT BY COMBINED EVALUATION OF RECIRCULATION AND ACCESS FLOW AT TWO DIFFERENT EXTRACORPOREAL BLOOD FLOWS Frantisek Lopot, Bohdan Nejedly, Sylvie Sulkova, Jan Blaha, Barbora Bodlakova, Martin Valek. Dept of Medicine, General Univ.Hosp., Prague - Strahov, Czech Republic

W572 COLOUR DOPPLER IMAGING OF RADIAL AND ULNAR ARTERY DEVELOPMENT AND FLOW CONTRIBUTION IN ARTERIOVENOUS FISTULAS Patrick Wiese, Johanna Eras, Christine Koch, Barbara Nonnast- Daniel. Med. Klinik IV/4, Nephrology, University Erlangen/Nuernberg, Erlangen, Germany

W573 CORRELATION OF FEEDING ARTERY PRESSURE(FAP) WITH THE CONTRALATERAL UPPER EXTREMITY BLOOD PRESSURE MEASURED BY SPHYGMANOMETRY(SPHY) WHEN CALCULATING STATIC PRESSURES (SP) DURING ARTERIOVENOUS HAEMODIALYSIS VASCULAR ACCESS INTERVENTIONS Michael Levine,1 Florin Gadalean,2 Anne Rismeyer,1 Jeffrey Wallach,1 Arif Asif,2 Jan Tawakol.2 1InterventionalNephrology, Milwaukee Nephrologists, Milwaukee, WI, USA; 2Nephrology, University of Miami, Miami, FL, USA

W574 STATIC THERMOGRAPHY (TG) IN EVALUATION OF VASCULAR ACCESS IN HAEMODIALYSED PATIENTS Jacek A. Pietrzyk,1 Przemyslaw Korohoda,2 Lidia Krawentek,2 Karol Krawentek,1 Katarzyna Zachwieja.1 1Dialysis Unit, Children’s Univ. Hosp. of Cracow, Cracow, Poland; 2Chair of Electronics, Univ. of Mining and Metallurgy (AGH), Cracow, Poland

436 POSTERS WEDNESDAY, JUNE 12

W575 DETECTION OF A-V DIALYSIS ACCESS STENOSIS BY BLOOD FLOW MONITORING -ULTRASOUND DILUTION VS. COLOR DOPPLER ULTRASOUND Christoph Schwarz,1 Christa Mitterbauer,1 Maryla Boczula,1 WEDNESDAY Thomas Maca,2 Martin Funovics,3 Georg Heinze,4 Matthias Lorenz,1 Josef Kovarik,1 Rainer Oberbauer.1 1Dept of Nephrology, Univ. of Vienna, Vienna, Austria; 2Dept of Angiology, Univ. of Vienna, Vienna, Austria; 3Dept of Radiology, Univ. of Vienna, Vienna, Austria; 4Dept of Medical Computer Sciences, Univ. of Vienna, Vienna

W576 UTILITY AND LIMITATIONS OF ACCESS BLOOD FLOW MONITORING FOR VASCULAR ACCESS FAILURE B. von Albertini,1 S. Qanadli,2 D. Hayoz,3 E. Haesler,3 M. Podesta,1 O. Pereira.1 1Centre de Dialyse, Clinique Cecil; 2Interventional Radiology Service, Univ. Hosp.; 3Angiology Division, Univ. Hosp., Lausanne, Switzerland

W577 ERRORS OF ACCESS FLOW (AF) DILUTION METHODS RESULTING FROM PROCEDURAL TECHNIQUE Nikolai Krivitski. Engineering, Transonic Systems Inc., Ithaca, NY, United States

W578 LONG TERM ARTERIO-VENOUS FISTULA SURVIVAL - A CROSS SECTIONAL STUDY Shahrzad Ossareh, Hazhir H. Beigvand, Azeen Alizadeh Asl, Shokoufeh Savaj, Ahad J. Ghods. Nephrology, Iran University of Medical Sciences, Tehran, Iran

W579 LONGER MATURATION TIME IMPROVES ARTERIOVENOUS FISTULA SURVIVAL: A PROSPECTIVE MULTI-CENTER STUDY Pietro Ravani,1 Giuliano Brunori,2 Giovanni Cancarini,2 Salvatore Mandolfo,3 Enrico Imbasciati,3 Daniale Marcelli,4 Fabio Malberti.1 1Div. Nefrologia e Dialisi, Istit. Ospitalieri, Cremona, Italy; 2Catt. Nefrologia, Univ. Brescia, Brescia, Italy; 3Servizio Dialisi, Osp. Maggiore, Lodi, Italy; 4Clinical Management Europe, Fresenius Medical Care, Bad Homburg, Germany

W580 VASCULAR ACCESS FOR HEMODIALYSIS IN VERY ELDERLY URAEMIC PATIENTS: ARE ARTERIOVENOUS FISTULAE (AVF) EFFECTIVE? Francesco Bianco,1 Massimiliano Martone,1 Marco Ianche,1 Silvana Savoldi,1 Giovanni Panzetta,1 Francesco Pancrazio,2 Elisabetta Rauber.2 1U.C.Nefrologia e Dialisi, Azienda Osp.Riuniti Trieste, Trieste, Italy; 2U.C.Clinica Chirurgica, Azienda Osp. Riuniti Trieste, Trieste, Italy

W581 MALFUNCTION OF VASCULAR ACCESS IN HAEMODIALYSIS PATIENTS IN ASSOCIATION WITH SERUM HOMOCYSTEIN LEVELS AND OTHER PARAMETERS Parthena Kiriklidou, Dafni Meimaridou, Eleni Manou, Efstathios Mitsopoulos, Dorothea Papadopoulou, Eudoxia Ginikopoulou, Georgia Papaioannou, Georgios Visvardis, Ioannis Griveas, Eleni Martziou, Rafail Papadopoulos, Svetlana Kalanidou, Laura Rottstein, Georgios Sakellariou. 1Dept of Nephrology, Papageorgiou General Hosp., Thessaloniki, Greece; 2Dept of Hematology and Biochemical Lab., Papageorgiou General Hosp., Thessaloniki, Greece

W582 SHORT TERM OUTCOME OF THE FIRST ARTEROVENOUS FISTULA (AVF) IN HAEMODIALYSIS PATIENTS: A MULTICENTER EXPERIENCE Giuliano Brunori,1 Pietro Ravani,2 Salvatore Mandolfo,3 Ezio Movilli,1 Simona Guerini,1 Fabio Malberti,2 Enrico Imbasciati,3 Giovanni Carlo Cancarini.1 1Nephrology, Univ. and Spedali Civili, Brescia, Italy; 2Nephrology, Ospedale, Cremona, Italy; 3Dialisi, Ospedale, Lodi, Italy

437 WEDNESDAY, JUNE 12 POSTERS

W583 EVALUATION OF HEREDITARY TROMBOPHILIA AND THROMBOSIS OF VASCULAR ACCESS IN PATIENTS ON HAEMODIALYSIS Magdalena Mokrejšová, Jana Lachmanová, Jan Kvasnicka. 1st Dept of Medicine, 1st Med. School, Charles Univ., Prague, Czech Republic

W584 ROLE OF GENETIC FACTORS IN VASCULAR ACCESS THROMBOSIS IN HAEMODIALYSIS PATIENTS F. Belgin Atac,1 Namik Ozbek,2 F. Nurhan Ozdemir,3 Hasibe Verdi,1 Mehmet Haberal.4 1Department of Molecular Biology, Baskent University Faculty of Medicine, Ankara, Turkey; 2Department of Pediatric Hematology, Baskent University Faculty of Medicine, Ankara, Turkey; 3Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey; 4Department of General Surgery, Baskent University Faculty of Medicine, Ankara, Turkey

W585 A SINGLE CENTRE EXPERIENCE WITH PERMANENT VASCULAR ACCESS IN CHRONIC HAEMODIALYSIS PATIENTS Diana-Silvia Micu,1 Ileana Teodoru,1 Elena Rusu,1 Mihai Voiculescu,1 Sorin Baila.2 1Internal Medicine and Nephrology, Fundeni Clinical Institute, Bucharest, Romania; 2Vascular Surgery, C.C.C. Iliescu Institute of Cardiovascular Diseases, Bucharest, Romania

W586 VASCULAR ACCESS SURVIVAL AND MORBIDITY ON DAILY DIALYSIS: FOUR YEARS EXPERIENCE ON HOME AND LIMITED CARE HAEMODIALYSIS Francesca Bermond, Manuel Burdese, Fabrizio Fop, Elisabetta Mezza, Giorgio Soragna, Massimo Gai, Alfonso Pacitti, Giovanni Mangiarotti, Giuseppe Segoloni, Giorgina Barbara Piccoli. Internal Medicine, Chair of Nephrology, University of Turin, Italy

W587 ENDOVASCULAR RADIATION THERAPY FOR HAEMODIALYSIS VASCULAR ACCESS STENOSIS (THE BRAVO STUDY) Prabir Roy-Chaudhury,1 Sanjay Mishra,2 Pia Mikkelsen Lynch,3 (for the BRAVO Study Investigators). 1Division of Nephrology, University of Cincinnati Medical Center, Cincinnati, OH, United States; 2Department of Radiology, Mayo Clinic, Rochester, MN, United States; 3Novoste Corporation, Norcross, GA, United States

W588 EARLY VASCULAR ACCESS FAILURE IS ASSOCIATED WITH CARDIOVASCULAR MORTALITY IN HAEMODIALYSIS PATIENTS Young Ok Kim, Sun Ae Yoon, Mi Jung Shin, Chul Woo Yang, Dong Chan Jin, Yong Soo Kim, Suk Young Kim, Euy Jin Choi, Yoon Sik Chang, Byung Kee Bang. Internal Medicine, The Catholic University of Korea, Seoul, Korea

W589 PROSPECTIVE RANDOMIZED STUDY EVALUATING THE EFFECTIVENESS OF BRACHITHERAPY IN THE PREVENTION OF RE-STENOSIS OF VASCULAR ACCESS AFTER BALLOON ANGIOPLASTY: PRELIMINARY RESULTS Giuseppe Bacchini,1 Luigi Palmieri,2 Antonio Capello,3 Vincenzo La Milia,1 Simeone Andrulli,1 Cristina Frigerio,2 Alessandro Colombo,2 Francesco Locatelli,1 Pietro Pozzoni.1 1Nephrology and Dialysis, A. Manzoni Hospital, Lecco, Italy; 2Radiotherapy Department, A. MAnzoni Hospital, Lecco, Italy; 3Radiology Department, A.Manzoni Hospital, Lecco, Italy

W590 HEMOGLOBIN LEVEL AND VASCULAR ACCESS SURVIVAL IN HAEMODIALYSIS PATIENTS Jose Maria Garrancho, Mihaly Tapolyai, Mariana Arranz, Juan Antonio Ayala, Daniele Marcelli. FMC Spain Study Group, FMC, Madrid, Spain

438 POSTERS WEDNESDAY, JUNE 12

W591 MATRIX METALLOPROTEINASE INHIBITION REDUCES INTIMAL HYPERPLASIA BY PREVENTING ELASTIN BREAKDOWN. STUDIES IN A PORCINE ARTERIOVENOUS- GRAFT MODEL WEDNESDAY Joris I. Rotmans,1,2 Evelyn Velema,2 Hence J.M. Verhagen,3 Jan D. Blankensteijn,3 Gerard Pasterkamp,2 Erik S.G. Stroes.1 1Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands; 2Experimental Cardiology, 3Vascular Surgery, University Medical Center, Utrecht, Netherlands

W592 ARTEROVENOUS ACCESS FOR HEMODIALYSIS AND DEATH IN SOUTHERN ITALIAN REGION: DATA OF 2nd URAEMIC REGISTRY OF CAMPANIA Biagio Raffaele Di Iorio,1 Nicola Cillo,2 Massimo Cirillo,3 Vittorio Emanuele Andreucci,4 Natale Gaspare De Santo.3 1U.O. di Nefrologia e Dialisi, ASL AV/2, Solofra, Avellino, Italy; 2U.O. di Nefrologia e Dialisi, ASL AV/1, Ariano Irpino, Avellino, Italy; 3Cattedra di Nefrologia, Seconda Universita di Napoli, Napoli, Italy; 4Cattedra di Nefrologia, Universita Federico Secondo, Napoli, Italy

W593 IMPACT OF “DE NOVO” MORBIDITY CAUSED BY THE LACK OF ARTERIOVENOUS FISTULAE OVER SURVIVAL IN CHRONIC RENAL FAILURE PATIENTS Teresa Ortega,1,2 Dario Moreno,1,2 Carmen Diaz,1 Jose Baltar,1 Pablo Rebollo,1 Covadonga Valdes,1,2 Monica G- Mendoza,2 Francisco Ortega.1,2 1Nephrology Unit, Hospital Central de Asturias, Oviedo, Asturias, Spain; 2Inv. Results & QoL Unit, Inst. Reina Sofia for Nephrol. Res., Oviedo, Asturias, Spain

W594 EPIDEMIC INFECTIONS CAUSED BY “AQUATIC” BACTERIA IN PATIENTS UNDERGOING HAEMODIALYSIS VIA CENTRAL VENOUS CATHETERS Marco D’Amico,1 Stefano Mangano,1 Daniela Martinelli,1 Mario Spinelli,2 Anna Lisa Fumagalli,3 Angela Gangemi,3 Egidio Vigano,4 Rossana Grilli,1 Mario Fraticelli,1 Carlo Grillo.1 1Nephrology-Dialysis Unit, S. Anna Hospital, Como, Italy; 2Clinical Laboratory, S. Anna Hospital, Como, Italy; 3Medical Direction, S. Anna Hospital, Como, Italy; 4Microbiology Laboratory, Civile Hospital, Legnano, Italy

W595 REDUCTION OF BLEEDING COMPLICATIONS IN HEMODIALYSIS PATIENTS WITH HIGH CONCENTRATION TRISODIUM CITRATE FOR HAEMODIALYSIS CATHETER LOCKING; A PROSPECTIVE MULTICENTER DOUBLE-BLIND RANDOMISED CONTROLLED TRIAL Marcel Weijmer, Rene van den Dorpel, Jos van Geelen, Han Groeneveld, Brigitte van Jaarsveld, Marion Koopmans, Caatje le Poole, Anita Schrander-van der Meer, Carl Siegert, Koen Stas, Peter van de Ven, Pieter ter Wee. Department of Nephrology, Vrije Universiteit Medical Center, Amsterdam, Netherlands

W596 LONG SHOT-GUN TIP FEMORAL CATHETERS HAVE BETTER IMMEDIATE FUNCTION, BETTER ACTUAL BLOOD FLOW AND LOWER RECIRCULATION RATES Marcel Weijmer, Marc Vervloet, Pieter ter Wee. Department of Nephrology, Vrije Universiteit Medical Center, Amsterdam, Netherlands

W597 THE MIDDLE-ARM FISTULA: A NEW FIRST-CHOICE SURGICAL APPROACH IN HAEMODIALYSIS COMPLICATED PATIENTS Simona Zerbi, Giuseppe Bonforte. Nephrology and Dialysis, Desio Hospital, Desio, Milan, Italy

439 WEDNESDAY, JUNE 12 POSTERS

W598 ARTERIOVENOUS FISTULA (AVF) CONSTRUCTION BY NEPHROLOGIST - A NECESSITY IN RURAL NEPHROLOGY PRACTICE Balasubramaniam Jeyaraj, Balachander . Nephrology, Kidney Care Centre, Tirunelveli, Tamilnadu, India

W599 ARTERIOVENOUS FISTULA SURGERY PERFORMED BY RENAL PHYSICIAN: EXPANDING THE ROLE OF NEPHROLOGIST Gopesh K. Modi. Department of Nephrology, Bhopal Memorial Hospital & Research Center, Bhopal, MP, India

W600 VASCULAR ACCESS FOR HAEMODIALYSIS: IMPORTANCE OF AUTONOMY BY THE NEPHROLOGIST Francesca Tentori, Cinzia Ballabeni, Laura Buzzi, Massimo Maccario, Stefania Martino, Lara Traversi, Daniele Ciurlino, Silvio Bertoli. Unità Operativa di Nefrologia e Dialisi, Policlinico Multimedica, Sesto San Giovanni, MI, Italy

W601 DETERMINANTS OF VASCULAR ACCESS USE IN THE AUSTRALIAN HAEMODIALYSIS POPULATION Kevan Polkinghorne,1 Stephen McDonald,2 Robert Atkins,1 Peter Kerr.1,2 1Nephrology, Monash Medical Centre, Melbourne, Victoria, Australia; 2ANZDATA Registry, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia

W602 NEW PORT FOR SHUNTLESS VASCULAR ACCESS Shigeki Toma,1 Toru Shinzato,2 Hiroyoshi Fukui,3 Kenji Maeda.2 1Internal Medicine, Toma Clinic, Nishihara-cho, Okinawa, Japan; 2Daiko Medical Engineering Research Institute, Nagoya, Aichi-Ken, Japan; 3Internal Medicine, Kumamoto Chuo Hospital, Kumamoto, Kumamoto-ken, Japan

W603 SUCCESSFUL CENTRAL VENOUS CATHETERIZATION WITH LONGER CATHETER LIFE SPAN AND LOWER RATE OF COMPLICATIONS Ahmad Mooraki, Aria Jenabi, Mosadegh Jabbari, Seyed Reza Mirpour, Behrooz Broumand. Nephrology Department,Rasool-Akram Medical Center, Iran University of Medical Sciences, Tehran, Iran

W604 SUBSTANTIAL REDUCTION OF INFECTIOUS COMPLICATIONS IN HAEMODIALYSIS PATIENTS WITH TRISODIUM CITRATE 30% AS CATHETER LOCKING SOLUTION; A PROSPECTIVE MULTICENTER DOUBLE-BLIND RANDOMISED CONTROLLED TRIAL Marcel Weijmer, Rene van den Dorpel, Jos van Geelen, Han Groeneveld, Brigitte van Jaarsveld, Marion Koopmans, Caatje le Poole, Anita Schrander-van der Meer, Carl Siegert, Koen Stas, Peter van de Ven, Pieter ter Wee. Department of Nephrology, Vrije Universiteit Medical Center, Amsterdam, Netherlands

W605 A PROTOCOL FOR THE MANAGEMENT OF THE THROMBOSED HAEMODIALYSIS PERMANENT CATHETER Ping Zhang, Jian-yong Wu, Wen-han Pen, Jiang-hua Chen. Nephrology Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China

W606 ADVANTAGES OF LOCKED ANTIBIOTICS IN CATHETER RELATED INFECTIONS REGARDING HAEMODIALYSIS Petar Dejanov, Angel Oncevski, Vesna Gerasimovska. Department of Nephrology, Clinical Center, Skopje, Macedonia, Macedonia, F.Y.R.M.

440 POSTERS WEDNESDAY, JUNE 12

W607 BACTEREMIA ASSOCIATED WITH TUNNELED FEMORAL CATHETERS FOR HEMODIALYSIS:EFICIACY OF ANTIBIOTIC THERAPY Vesna Gerasimovska, Angel Oncevski, Petar Dejanov . WEDNESDAY Dept of Nephr., Clinical Ctr, Skopje, F.Y.R.M.

W608 MODIFIED TIMESAVING METHOD TO CREATE BUTTONHOLE ALLOWING IMMEDIATE BUTTONHOLE PUNCTURE Toru Shinzato,1 Shigeki Toma,2 Hiroyosi Fukui,3 Kenji Maeda.1 1Research Center, Daiko Medical Engineering Research Institute, Nagoya, Aiti-Ken, Japan; 2Internal Medicine, Toma Clinic, Nakagami-gun, Okinawa, Japan; 3Internal Medicine, kumamoto Chuo Hospital, Kumamoto, Kumamoto-ken, Japan

W609 FIBROBLASTS AND MYOFIBROBLASTS CONTRIBUTE TO VENOUS NEOINTIMAL HYPERPLASIA AND VENOUS STENOSIS IN PTFE DIALYSIS ACCESS GRAFTS Prabir Roy-Chaudhury, Burnett Kelly, Lynn McKee, Janice Armstrong, Sue Heffelfinger. Hemod.Vascular Access Res. Group, Univ.of Cincinnati, Cincinnati, OH, USA

W610 SMOOTH MUSCLE CHANGES IN THE CEPHALIC VEIN OF RENAL FAILURE PATIENTS BEFORE USE AS AN ARTERIOVENOUS FISTULA Mohammed Al-Homrany,1 Mahmoud Wali,1 Refaat Eid.1 1Medicine, 2Vascular Surgery, 3Pathology, King Khalid Univ., Abha, Aseer, Saudi Arabia

W611 A LONGITUDINAL STUDY OF C-REACTIVE PROTEIN IN HEMODIALYSIS PATIENTS WITH CENTRAL VENOUS CATHETERS AND WITH ARTERIOVENOUS FISTULAS Arcangelo Di Maggio, Francesco Marangio, Nicola Ettore Montemurro, Gianfranco Orbello, Domenico Santese, Assunta Lucia Antonaci, Cosimo Lodeserto. Department of Nephrourology, SS. Annuziata Hospital, Taranto, Italy

W612 THE EFFECTS OF ARTERIOVENOUS FISTULA ON UPPER LIMBS NERVE CONDUCTION VELOCITY IN CHRONIC HAEMODIALYSIS PATIENTS Hamid Reza Samimagham,1 Ahmad Negahi,1 Roya Fayas,2 Elham Bousheri.3 1Internal Medicine, Hormozgan Medical University, Bandar Abass, Hormozgan, Iran; 2Internal Medicine, Hormozgan Medical University, Bandar Abass, Hormozgan, Iran; 3Internal Medicine, Hormozgan Medical University, Bandar Abass, Hormozgan, Iran

W613 IMPACT OF LEFT-SIDED INTERNAL JUGULAR VEIN CATHETERIZATION ON IPSILATERAL DIALYSIS ACCESS CREATION Octavio Salgado,1 Bella Urdaneta,1 Berkis Colmenares,1 Carmen Flores.2 1Renal Service, University Hospital, Maracaibo, Zulia, Venezuela; 2Unidad de Diálisis El Sol, Maracaibo, Zulia, Venezuela

W614 THE LOWER LIMB A-V FISTULAS: AN UNDERESTIMATED RESOURCE FOR DIFFICULT PATIENTS Luisa Berardinelli, Claudio Beretta, Monica Carini. Div.of Vascular Surgery and Kidney Transpl., Policlinico-Univ. Hosp., IRCCS, Milan, Italy

W615 THE PROSPECTIVE COMPARISON OF THE SUPERFICIAL FEMORAL VEIN TRANSPOSITION TO THE SYNTHETIC GRAFTS IN LOWER EXTREMITY VASCULAR ACCESS SURGERY FOR HAEMODIALYSIS Acar Tuzuner, Selcuk Hazinedaroglu, Derya Tepe, Mehmet Ali Yerdel. General Surgery, Ankara Univ.Medical Faculty, Ankara, Turkey

441 WEDNESDAY, JUNE 12 POSTERS

W616 EARLY AND LATE FOLLOW-UP RESULTS OF THE “EXOTIC” ARTERIOVENOUS FISTULAS FOR HAEMODIALYSIS Acar Tuzuner, Feza Karakayali, Selcuk Hazinedaroglu, Mehmet Ali Yerdel. General Surgery, Ankara University Medical Faculty, Ankara, Turkey

W617 TIP CULTURES (TC) IN PATIENTS (P) WITH CENTRAL VENOUS CATHETERS FOR HAEMODIALYSIS (HD): A USEFUL OR UNNECESSARY SURVEY? Daniele Damiani,1 Giacomo Fucale,2 Zsuzsanna Hollò,1 Marina Marino,2 Giorgio Triolo.1 1SCDO Nephrology-Dialysis, ASO C.T.O.- C.R.F. - O.M.A., Turin, Italy; 2Analysis Laboratory, ASO C.T.O.- C.R.F. - O.M.A., Turin, Italy

W618 CHLORHEXIDINE GLUCONATE REDUCES ENDOLUMINAL BACTERIAL COLONISATION AND CATHETER-RELATED INFECTIONS Paul Laboi,1 Nilar Than,1 Susan Barnett,1 Sunil Bhandari,2 John Turney.1 1Renal Unit, Leeds General Infirmary, Leeds, Yorkshire, United Kingdom; 2Renal Unit, Hull and East Yorkshire Hospitals, Hull, Yorkshire, United Kingdom

W619 PREVENTION OF CENTRAL VENOUS HAEMODIALYSIS CATHETERS RELATED BACTEREMIAS THANKS TO AN APPLICATION OF A RIFAMPIN-PROTAMINE OINTMENT AT THE EXIT-SITE Richard Montagnac,1 Francis Schillinger,1 Clarence Eloy.2 1Department of Nephrology and Dialysis, 2Laboratory of Microbiology, Hospital, Troyes Cédex

W620 ALTEPLASE, AT 1 MG BOLUS, IS EFFECTIVE ON TUNNELED HAEMODIALYSIS CATHETERS DECLOTTING Artur Mendes, Carla Rocha, Miguel Amaro, Teresa Adragão, Helena Boquinhas, Domingos Machado. Serviço Medicina Interna e Nefrologia, Hospital de Santa Cruz, Carnaxide, Portugal

W621 A NEW ACCESS (HEMAPORT®) FOR HAEMODIALYSIS Bo G. Danielson,1 Jarl Ahlmén,2 Dick Persson.3 1Renal Medicine, University Hospital and Hemapure AB, Uppsala, Sweden; 2Renal Medicine, Skövde and Visby Hospitals, Skövde and Visby, Sweden; 3Hemapure, Uppsala, Sweden

W622 SUBCUTANEOUS PORT DIALOCK®: THREE YEARS RESULTS IN A MONOCENTRIC STUDY Marco Pozzato, Giacomo Forneris, Silvia Berutti, Antonella Vallero, Marco Borca, Gian Maria Iadarola, Carlo Massara, Francesco Quarello. Nephrology and Dialysis Unit, San Giovanni Bosco Hospital, Turin, Italy

442 POSTERS WEDNESDAY, JUNE 12

ESRD TREATMENT COMPARISONS

W623 PROSPECTIVE COMPARISON OF CONVENTIONAL TO SHORT WEDNESDAY DAILY HAEMODIALYSIS USING AEK-10 (DESIGNED SPECIFICALLY FOR DAILY HAEMODIALYSIS) Akira Saito, Tadao Akizawa, Yasushi Asano, Seiji Ohira, Noritomo Itami, Masashi Suzuki, Takashi Akiba, Akira Kawashima, Naoki Kimata, Toshio Shinoda, Terukuni Ideura, Fumihiko Koiwa, Eriko Kinugasa, Takatoshi Kakuta, Yoshindo Kawaguchi, Naoyuki Osaka, Takao Shoji, Hiroshi Ogawa, Yoshiaki Takemoto, Kazuhiro Uchida, Hidemune Naito, Akira Fujimori, Masahiko Yorifuji, Jun Minakuchi, Kazuhiko Kawahara, Masahiko Nakamoto, Taihei Yanagida, Shozo Koshikawa. AEK-10, Japan DHD Study Group, Tokyo, Japan

W624 NOCTURNAL HAEMODIALYSIS IMPROVES NOCTURNAL HYPOXEMIA, LOWERS HEART RATE DURING SLEEP AND NORMALIZES PARASYMPATHETIC AND SYMPATHETIC MODULATION Christopher Chan,1 Pat Hanly,2 Jonathan Gabor,2 Peter Picton,1 Andreas Pierratos,3 John Floras.1 1Medicine, University Health Network, Toronto, ON, Canada; 2Medicine, St. Michael’s Hospital, Toronto, ON, Canada; 3Medicine, Humber River Regional Hospital, Toronto, ON, Canada

W625 DOES THE SHORT TERM IMPROVEMENT OBTAINED ON SHORT DAILY HAEMODIALYSIS PERSIST IN MIDDLE AND LONG TERM? Jules Traeger, Roula Galland, Walid Arkouche, Ehsan Delawari. Association pour Utilisation du Rein Artificiel, (A.U.R.A.L), Lyon, France

W626 BLOOD PRESSURE MODIFICATIONS IN HAEMODIALYSIS (HD) PATIENTS AT THE INITIATION OF HD IN COMPARISON WITH LONG TERM HD PATIENTS George Visvardis, Ioannis Griveas, Dorothea Papadopoulou, Eftathios Mitsopoulos, Parthena Kyriklidou, Eleni Manou, Dafni Meimaridou, Evdoxia Ginikopoulou, Rafail Papadopoulos, Svetlana Kalanidou, Lora Rottstein, George Sakellariou. Nephrology, Papageorgiou General Hospital, Thessaloniki, Georgia

W627 CONSTRAINTS ON HAEMODIALYSIS CARE: OPINIONS ON SHORTENING TREATMENT FROM NURSES IN THE DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (DOPPS) Hugh Rayner,1 Roger Greenwood,2 Jennifer Bragg-Gresham,3 Ronald Pisoni,3 Luis Piera,4 Christian Combe,5 Shunichi Fukuhara,6 Yasuchi Asano,7 Fumiaki Marumo,8 Donna Mapes,9 Friedrich Port.3 1Dept. of Renal Medicine, Birmingham Heartlands Hosp., Birmingham, UK; 2Dept. of Renal Medicine, Lister Hosp., Stevenage, UK; 3DOPPS, URREA, Ann Arbor, MI, USA; 4Nephrology Service, Hosp. General Vall d’Hebron, Barcelona, Spain; 5Nephrology and Haemodialysis Service, Hop. St-Andre, Bordeaux, France; 6Graduate School of Medicine and Public Health, Kyoto Unive., Kyoto, Japan; 7Div. of Nephrology, Dept. of Medicine, Jichi Medical School, Tochigi, Japan; 8Dept. of Medicine, Tokyo Medical and Dental Univ., Tokyo, Japan; 9Dialysis Medical Affairs, Amgen, Thousand Oaks, CA, USA

W628 DEATH AFTER WITHDRAWAL FROM DIALYSIS: THE MOST COMMON DEATH IN DIALYSIS PATIENTS IN A FRENCH POPULATION Beatrice Birmele, Maud Francois, Josette Pengloan, Patrick Francais, Serge Baudin, Georges Brillet, Didier Testou, Didier Le Chapois, Mohamed Fodil-Scherif, Olivier Grezard, Jean-Louis Jourdan, Mohamed Abaza, Gilles Fournier, Hubert Nivet, All Nephrologis Nephrologie, CHRU Bretonneau, Tours, France

443 WEDNESDAY, JUNE 12 POSTERS

W629 GABAPENTIN VERSUS LEVODOPA FOR THE TREATMENT OF RESTLESS LEGS SYNDROME IN HAEMODIALYSIS PATIENTS: AN OPEN-LABEL STUDY Hasan Micozkadioglu,1 Fatma Nurhan Ozdemir,1 Altug Kut,1 Siren Sezer,1 Umit Saatci.2 1Nephrology, Baskent University School of Medicine, Ankara, Turkey; 2Pediatric Nephrology, Baskent University School of Medicine, Ankara, Turkey

W630 IMPROVING SURVIVAL ON HAEMODIALYSIS USING 3 mEq/l POTASSIUM DIALYSATE Gina Khraish, George Dolson, Horacio Adrogue. Renal Section, Baylor College of Medicine, Houston, TX, United States

W631 END STAGE RENAL DISEASE PATIENTS AND AGEING SOCIETIES - SHORT TERM TRENDS AND LONG TERM PERSPECTIVES Hans-Juergen Schober-Halstenberg, Kirsten Haas, Guenther Edenharter, Ulrich Frei. Epidemiology, QuaSi-Niere gGmbH, Berlin, Germany

W632 EXPERIENCE OF DIALYZER REUSE USING A NEW LOW-COST PERACETIC ACID PREPARATION IN A THIRD-WORLD COUNTRY? IS IT STILL MISERY OR BLESSING? Salman Shakoh, Sheikh Rizwan. Shakoh’s Hemodialysis Center, The Kidney Clinic, Lahore, Punjab, Pakistan

W633 QUALITY EVALUATION OF DIALYSIS CENTER ORGANISATION: A REGIONAL PILOT PROCEDURE Jean-Pierre Wauters,1 Patrick Saudan,2 Georges Halabi,1 Thomas Perneger,2 Jean-Blaise Wasserfallen,1 Genevieve Droulez,2 Christine Oudy,1 Pierre-Yves Martin,2 Harold Feldman.2 1Division of Nephrology, University Hospital, Lausanne, Switzerland; 2Division of Nephrology, University Hospital, Geneva, Switzerland

W634 THE STUDY OF IMPLEMENTATION OF RENAL STANDARDS (SIRS) Anu Trehan,1 Jean Winterbottom,1 Beverley Lane,1 Robert Foley,1 Michael Venning,1 Robert Coward,1 Alison MacLeod,2 Ram Gokal.1 1SIRS Group, Manchester Royal Infirmary, United Kingdom; 2Renal Association Standards Subcommittee, United Kingdom

W635 REVIEW OF KIDNEY GRAFT OUTCOME IN NOCTURNAL HAEMODIALYSIS PATIENTS Brendan McCormick,1 Andreas Pierratos,2 Stanley Fenton,1 Jeffrey Zaltzman,3 Christopher Chan.1 1Department of Nephrology, Toronto General Hospital, Toronto, ON, Canada; 2Department of Nephrology, Humber River Regional Hospital, Toronto, ON, Canada; 3Department of Nephrology, St. Michael’s Hospital, Toronto, ON, Canada

W636 EXPERIMENTAL STUDY IN DIALYSIS-INDUCED PULMONARY EDEMA: A NEW TYPE OF DISEQUILIBRIUM SYNDROME Zhi Gang Wang, Zhen Wei Shi. 1Nephrology Division, Friendship Hospital, Beijing, China; 2Nephrology Division, Friendship Hospital, Beijing, China

444 POSTERS WEDNESDAY, JUNE 12

HAEMODIALYSIS: INFECTIONS, CANCER

W637 END STAGE RENAL DISEASE IN HANSEN’S DISEASE WEDNESDAY Carlo Lomonte,1 Bernardo Giammaria,1 Giovanni Marchio,1 Nicola Losurdo,1 Maurizio Antonelli,1 Francesco Casucci,1 Giovanni Chiarulli,1 Carlo Basile.2 1Division of Nephrology, Miulli Hospital, Acquaviva delle Fonti, Ba; 2Division of Nephrology, Hospital, Martina Franca, Ta, Italy

W638 COMPARING THE INCIDENCE OF CRYPTOSPORIDIUM INFECTION IN HAEMODIALYSIS PATIENTS WITH NORMAL POPULATION Shiva Seyrafian,1 Nader Pesteh Chian,2 Hassanali Yousefi,2 Maryam Kerdegari.3 1Nephrology, Isfahan Univ. of Medical Sciences, Isfahan, Iran; 2Parasitology, Isfahan Univ. of Medical Sciences, Isfahan, Iran; 3Internal Medicine, Isfahan Univ. of Medical Sciences, Isfahan, Iran

W639 EVALUATION OF SEROLOGICAL DIAGNOSIS TESTS FOR TUBERCULOSIS IN HAEMODIALYSIS PATIENTS Mitsuru Yanai,1 Yuki Uehara,1 Yoshiko Takahashi,2 Masaki Abe,2 Takahiro Kuragano,2 Hitoshi Kurokawa,3 Makoto Takeuchi,3 Shinobu Nagura,4 Tadashi Hoshino,1 Kuniki Hayashi,1 Yuji Nagura,2 Kazunari Kumasaka.1 1Departmet of Laboratory Medicine, Nihon University School of Medicine, Tokyo, Japan; 2Second Deaprtment of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan; 3Sekishin Clinic, Saitama, Japan; 4Shiki Ekimae Clinic, Saitama, Japan

W640 HUMAN IMMUNODEFICIENCY VIRUS (HIV)-INFECTED PATIENTS OUTCOME ON MAINTENANCE HAEMODIALYSIS – ONE INSTITUTION EXPERIENCE Rita Birne,1 Carla Rocha,1 Artur Mendes,1 Cristina Jorge,1 Margarida Goncalves,1 Ana Mascarenhas,2 Helena Boquinhas,1 Maria J. Pais.1 1Servico de Nefrologia, Hospital de Santa Cruz, Carnaxide-Lisboa, Portugal; 2Servico de Imunohemoterapia, Hospital de Santa Cruz, Carnaxide-Lisboa, Portugal

W641 MONITORING OF A VACCINE-INDUCED T-CELL RESPONSE IN IMMUNOCOMPETENT CONTROL PERSONS AND HEAMODIALYSIS PATIENTS AFTER INFLUENZA VACCINATION Martina Sester,1 Urban Sester,1 Barbara C. Gärtner,2 Martin K. Kuhlmann,1 Hans Köhler.1 1Medical Department IV, University of the Saarland, Homburg, Germany; 2Department of Virology, University of the Saarland, Homburg, Germany

W642 AREA-UNDER-THE-CURVE DERIVED ESTIMATE OF GANCICLOVIR FRACTION ELIMINATED BY HAEMODIALYSIS David Czock, Franz Maximilian Rasche, Frieder Keller. Division of Nephrology, University Hospital Ulm, Ulm, Germany

W643 PROSTATE SPECIFIC ANTIGEN (PSA) SCREENING IN PATIENTS ON CHRONIC HAEMODIALYSIS (HD) Naobumi Mise,1 Hideki Shimizu,1 Takahiro Nishi,1 Kyosuke Nishio,2 Akiko Ogura,3 Hisakazu Degawa,4 Yoshiaki Itaya,5 Hiroshi Nonaka,6 Richiko Sato,7 Kumiko Tabuchi,8 Hitoshi Tagawa,1 Tokuichiro Sugimoto.1 1Department of Nephrology, Mitsui Memorial Hospital, Tokyo, Japan; 2Shinkoiwa Clinic, Tokyo, Japan; 3Akihabara Jin Clinic, Tokyo, Japan; 4Shinkoiwa Clinic Funabori, Tokyo, Japan; 5Tsuchiya Clinic, Tokyo, Japan; 6Nonaka Iin, Tokyo, Japan; 7Richiko Sato, Tokyo, Japan; 8Izumi Clinic, Tokyo, Japan

445 WEDNESDAY, JUNE 12 POSTERS

W644 PAPILLARY THYROID CARCINOMA IN DIALYSED PATIENTS Hrvojka Tomic Brzac,1 Drasko Pavlovic,2 Mira Halbauer,1 Marija Despot,1 Miljenko Radetic.2 1Department of Nuclear Medicine and Radiation Protection, University Hospital Centre Zagreb, Zagreb, Croatia; 2Department of Nephrology and Dialysis, General Hospital “Sv. Duh”Zagreb, Croatia

W645 ANALYSIS OF RENAL CELL CARCINOMA (RCC) WITH ACQUIRED CYSTIC DISEASES OF KIDNEY (ACDK) IN CHRONIC DIALYSIS PATIENTS Akio Katayama, Yoshihiro Tominaga, Tsuneo Ueki, Norihiko Goto, Susumu Matsuoka, Toshihito Haba, Kazuharu Uchida. Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan

W646 PRESENT STATUS OF RENAL CELL CARCINOMA IN DIALYSIS PATIENTS: QUESTIONNAIRE STUDY IN 2002 Isao Ishikawa. Div of Nephrology, Dept of Internal Medicine, Kanazawa Medical University, Uchinada, Ishikawa, Japan

W647 RENAL REPLACEMENT THERAPY IN PATIENTS WITH MULTIPLE MYELOMA Diana-Silvia Micu, Camelia Ionescu, Gener Ismail, Cristina Bucsa, Elena Simona Ioanitescu, Raluca Bobeica, Mihai Voiculescu. Internal Medicine and Nephrology, Fundeni Clinical Institute, Bucharest, Romania

W648 INDIVIDUAL DOSE ADJUSTMENT OF CYTOTOXIC DRUGS IN HAEMODIALYSIS PATIENTS WITH MALIGNANCIES Benjamin Boesler,1 David Czock,1 Frieder Keller,1 Martin Griesshammer,2 Thomas Seufferlein,3 Franz Maximilian Rasche.1 1Division of Nephrology, Internal Medicine II, University Hospital Ulm, Ulm, Germany; 2Internal Medicine III, University Hospital Ulm, Ulm, Germany; 3Internal Medicine I, University Hospital Ulm, Ulm, Germany

446 POSTERS WEDNESDAY, JUNE 12

HAEMOFILTRATION, HAEMODIAFILTRATION AND OTHER MODALITIES WEDNESDAY

W649 SPECIFIC AUTOANTIBODY ADSORPTION IN PATIENTS WITH IDIOPATHIC DILATED CARDIOMYOPATHY Johannes Mueller,1 Gerd Wallukat,2 Angela Englert,1 Michael Dandel,1 Roland Hetzer.1 1Cardiac Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany; 2Max-Delbrueck-Zentrum Berlin, Berlin, Germany

W650 HEPARIN FREE CONTINUOUS VENO VENOUS HAEMOFILTRATION THERAPY IN RENAL ALLOGRAFT RUPTURE AFTER SURGICAL REPAIR Qiang He, Jianghua Chen, Ping Zhang, Jianyong Wu. The Nephrology Center,The 1st Affiliated Hospital, Medical College,Zhejiang University, Hangzhou, Zhejiang, China

W651 CITRATE PHARMACOKINETICS AND METABOLISM IN CIRRHOTIC AND NONCIRRHOTIC CRITICALLY ILL PATIENTS Ludwig Kramer,1 Edith Bauer,2 Christian Joukhadar,3 Wolfram Strobl,4 Alexandra Gendo,1 Wilfred Druml.2 1Dept.of Medicine IV, Medical School, Univ of Vienna, Vienna, Austria; 2Dept.of Medicine III, Div. of Nephrology, Medical School, Univ of Vienna, Vienna, Austria; 3Clinical Pharmacology, Medical School, Univ of Vienna, Vienna, Austria; 4Danube University Krems, Institute of Biomedical Technology, Krems, Austria

W652 REGIONAL CITRATE ANTICOAGULATION IN CRITICALLY ILL PATIENTS TREATED BY PLASMA FILTRATION COUPLED WITH ADSORBENT TECHNOLOGY Filippo Mariano,1 Ciro Tetta,2 Maurizio Stella,3 Piera Biolino,4 Antonio Miletto,4 Giorgio Triolo.1 1Department of Area of Medicine, Nephrology and Dialysis Unit, CTO Hospital, Turin, Italy; 2Division of Medicine, Fresenius Medical Care, Bad Homburg, Germany; 3Department of Plastic Surgery and Burns Unit, CTO Hospital, Turin, Italy; 4Department of Emergency, Intensive Care Unit, CTO Hospital, Turin, Italy

W653 EFFECT OF CONTINUOUS VENOU-VENOUS HAEMOFILTRATION ON REMOVING PLASMA INFLAMMATORY MEDIATORS OF HAEMORRHAGIC FEVER WITH RENAL SYNDROME Hongli Jiang,1 Wujun Xue,2 Aiping Yin,2 Daqing Li,1 Xueliang Feng.2 1Hemodialysis Center, 2Department of Nephrology, The First Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi Province, China

W654 NOVEL MID-DILUTION DIALYZER “NEPHROS® MD 190” – FIRST CLINICAL PERFORMANCE DATA Detlef H. Krieter,1 Hélène Leray Moragues,1 Gregory Collins,2 Jim Summerton,2 Edward Spence,2 Bernard Canaud.1 1Nephrology, University of Montpellier, Lapeyronie Hospital, Montpellier, France; 2Nephros Inc., New York, United States

W655 ADSORPTIVE SATURATION TIME OF FILTER MEMBRANES IN HAEMOFILTRATION Hongli Jiang,1 Aiping Yin,2 Shu Kong,3 Wujun Xue,2 Fengchi Ju,3 Daqing Li,1 Xueliang Feng.2 1Hemodialysis Center, 2Department of Nephrology, The First Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China; 3Department of Biomedicine Engineering, Medical School of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China

447 WEDNESDAY, JUNE 12 POSTERS

W656 EARLY USE OF CONTINUOUS VENOVENOUS HAEMOFILTRATION (CVVH) IN THE POSTOPERATIVE COURSE AFTER CARDIAC SURGERY Paolo Cappelli,1 Vittorio Sirolli,1 Valeria Palma,1 Uwe Brummer,1 Lorenzo Di Liberato,1 Luigi Amoroso,1 Patrizia Muscianese,1 Giovanni Scipioni,2 Ester Miniero,2 Mario Bonomini.1 1Department of Medicine, SS Annunziata University Hospital; 2Department of Intensive Care and Cardiac Surgery, S Camillo De Lellis Hospital, Chieti, Italy

W657 MIDDLE MOLECULE AND PROTEIN BOUND TOXIN REMOVAL BY AN FX-CLASS DIALYSER IN HAEMODIALYSIS AND HAEMODIAFILTRATION: A RANDOMISED CROSS-OVER STUDY Bert Bammens, Pieter Evenepoel, Kathleen Claes, Dirk Kuypers, Bart Maes, Kristin Verbeke, Yves Vanrenterghem. Department of Medicine, Division of Nephrology and Gastrointestinal Research Centre, University Hospital Gasthuisberg, Leuven, Belgium

W658 EFFECT OF MEMBRANE PORE-SIZE IN CONVECTION OF PROINFLAMMATORY CYTOKINES IN AN EX VIVO MODEL Alessandra Brendolan, MaryLou Wratten, Luisa Sereni, Paola Inguaggiato, Claudio Ronco. Dept Nephrol, Dial,Transpl, St Bortolo Hosp, Vicenza, Italy

W659 REMOVAL OF PRO-APOPTOTIC SUBSTANCES WITH HYPER PERMEABLE CELLULOSE TRIACETATE IN AN EX-VIVO SEPSIS MODEL Claudio Ronco,1 Alessandra Brendolan,1 Valeria Bordoni,1 Elisabetta Galloni,1 Fiorella Gastaldon,1 Antonio Fortunato,1 Philip Everard.2 1Dept Nephrol Dial Transplant, St Bortolo Hosp, Vicenza, Italy; 2Dept Med Res, Nipro Europe, Zaventem, Belgium

W660 ATTENUATION OF MONOCYTE DYSFUNCTION IN PATIENTS WITH ACUTE PANCREATITIS DURING CONTINUOUS VENO- VENOUS HAEMOFILTRATION THERAPY Chen Yu, Zhi-Hong Liu, Xiao-Hua Guo, Zhao-Hong Chen, Da-Xi Ji, Lei-Shi Li. Research Institute of Nephrology, Jinling Hospital,Nanjing University School of Medicine, Nanjing, Jiangsu, China

W661 CHANGES OF PEGYLATED INTERFERON-a2a KINETICS DURING EXPERIMENTAL HD IN RELATION TO DIALYZER MEMBRANES G. Barril,1 J.A. Quiroga,2 P. Sanz,1 R. Selgas,1 V. Carreño.2 1Nephrology, Hospital U. la Princesa, Madrid, Spain; 2FEHV, Fundación Estudio de Hepatitis Virales, Madrid, Spain

W662 IMMUNOADSORPTION THERAPY: CAPACITY, EFFICACY AND ELIMINATION RATE Kerstin Humme, Susanne Amann, Uwe Kuhlmann. Clinic of Internal Medicine, University of Marburg, Marburg, Germany

W663 ABSORPTION OF COMPLIMENT COMPONENT FACTOR D AND OTHER PROTEINS BY DEXTRAN SULFATE COLUMN IN PATIENTS ON HAEMODIALYSIS Hiroshi Ogawa,1 Takashi Nagaya,1 Yoshihiro Ota,1 Ryojiro Nakano,1 Osamu Oda.2 1Dept. of Internal Medecine, Shinseikai Dai-ichi Hospital, Nagoya, Aichi, Japan; 2The Bio-Dynamics Research Institute, Nagoya, Japan

448 POSTERS WEDNESDAY, JUNE 12

W664 SUSTAINED LOW EFFICIENCY DAILY DIALYSIS (SLEDD) AND DIAFILTRATION (SLEDDf) – TOWARDS AN ADEQUATE THERAPY Mark Marshall,1 Tianmin Ma,1 Krishan Madhan,1 Ben Barry,2 WEDNESDAY David Galler,2 Nigel Rankin,2 Catherine Simpson,2 Tony Williams.2 1Department of Renal Medicine, Middlemore Hospital, Otahuhu, Auckland, New Zealand; 2Department of Intensive Care Medicine, Middlemore Hospital, Otahuhu, Auckland, New Zealand

W665 PROTEIN LOSSES IN HIGH-FLUX HAEMOFILTRATION (HF) Cristina Canova, Elena Mancini, Emanuele Mambelli, Serena Bainotti, Antonio Santoro. Nephrology and Dialysis Malpighi, St.Orsola-Malpighi Hospital, Bologna, Italy

W666 APPLICATION OF ADVANCED HIGH FLUX POLYSULFONE MEMBRANES IN POST-DILUTIONAL HAEMODIAFILTRATION (PD-HDF) Katja Martin, H. Leray-Moragues, D.H. Krieter, B. Canaud. Nephrology, CHU Lapeyronie, Montpellier, France

W667 AMANITA MUSHROOM POISONING IN CHILDREN: ROLE OF PLASMAPHERESIS Jasna Slavicek, Zvonimir Puretic, Snjezana Glavas-Boras, Ruzica Smalcelj, Ivan Barisic, Ivancica Hršak- Puljic, Vladimir Slavicek. Dialysis Department, UHC Zagreb, Zagreb, Croatia

W668 SAFETY AND EFFICACY OF EXTRACORPOREAL BILIRUBIN- ADSORPTION IN PATIENTS WITH ACUTE RENAL AND LIVER FAILURE Susanne Amann, Kerstin Humme, Uwe Kuhlmann. Clinic of Internal Medicine, Dept. Nephrology, University of Marburg, Marburg, Germany

W669 EXTRACORPOREAL ALBUMIN DIALYSIS MARS FOR PATIENTS WITH HEPATORENAL SYNDROME Steffen Mitzner, Reinhard Schmidt. Medicine, Division of Nephrology, Rostock, Germany

W670 EFFICACY AND TOLERANCE OF MOLECULAR ADSORBENTS RECIRCULATING SYSTEM (MARS) IN PATIENTS WITH MULTIPLE ORGAN FAILURE ASSOCIATED WITH SEVERE LIVER DISEASE Garcia-Fernandez Nuria, Manrique Joaquin, Rossich Esther, Hernandez Astrid, Pujante Dolores, Lavilla Francisco Javier, Errasti Pedro, Purroy Andres. Nephrology, Univ. Clinic of Navarra, Pamplona, Navarra, Spain

449 WEDNESDAY, JUNE 12 POSTERS

PD: CARDIOVASCULAR MORBIDITY AND MORTALITY

W671 INCREASED FIBRINOGEN LEVELS ON PD PATIENTS. CORRELATION WITH INFLAMMATION AND CARDIOVASCULAR DISEASE P. Pangidis, A. Aggelou, I. Ioannidis, N. Georgilas, D. Kanetidis, K. Tsitsela, I. Tsoukidou, S. Arabatzi, V. Liakopoulos, G. Vayonas. Department of Nephrology, 2nd IKA Hospital, Thessaloniki, Greece

W672 APO(E) IN PATIENTS ON PERITONEAL DIALYSIS P. Pangidis, A. Aggelou, D. Kanetidis, N. Georgilas, A. Vakaloudi, A. Taralidou, I. Ioannidis, V. Liakopoulos, G. Vayonas. Department of Nephrology, 2nd IKA Hospital, Thessaloniki, Greece

W673 HIGHER CARDIO-VASCULAR MORBIDITY AND ACTIVITY OF INFLAMMATORY PROCESS IN OBESE PATIENTS ON PERITONEAL DIALYSIS: DOES OBESITY-INFLAMMATION- ATHEROSCLEROSIS (OIA) SYNDROME EXIST? Tomasz Stompor,1 Wladyslaw Sulowicz,1 Mieczyslaw Pasowicz,2 Marek Rajzer,2 Aldona Dembinska-Kiec,3 Kalina Kawecka-Jaszcz,2 Jacek S. Dubiel,2 Katarzyna Janda,1 Barbara Tabor,1 Katarzyna Wojcik,1 Danuta Sorysz,2 Wieslawa Tracz,2 Anna Zdzienicka,3 Piotr Klim 1Chair and Department of Nephrology, Jagiellonian University, Cracow, Poland; 2Institute of Cardiology, Jagiellonian University, Cracow, Poland; 3Department of Clinical Biochemistry, Jagiellonian University, Cracow, Poland

W674 INTERLEUKIN-6 (IL-6) AND IgA ANTI-CHLAMYDIA ANTIBODY TITERS ARE INDEPENDENT FACTORS AFFECTING THE PROGRESSION OF CAROTID ATHEROSCLEROSIS IN CAPD PATIENTS Hyun Jin Kim, Beom Seok Kim, So Rae Choi, Soo Young Yoon, Hyung Cheon Park, Shin Wook Kang, Kyu Hun Choi, Seong Kyu Ha, Ho Yung Lee, Dae Suk Han. Department of Internal Medicine, The Institute of Kidney Disease, College of Medicine, Yonsei University, Seoul, Republic of Korea

W675 BLOOD GLUCOSE LEVELS: A RISK FACTOR FOR CORONARY CALCIFICATION IN PERITONEAL DIALYSES Adriano Luiz Ammirati, Aparecida Dalboni, Miguel Cenderoglo, Sergio A. Draibe, Maria Eugenia Canziane. Nephrology, Federal University of Sao Paulo, Sao Paulo, Brazil

W676 RELATIONSHIP BETWEEN HIGH SENSITIVITY C-REACTIVE PROTEIN (hs-CRP), PULSE PRESSURE (PP) AND ATHEROSCLEROTIC CORONARY ARTERY DISEASE (CAD) IN CHRONIC PERITONEAL DIALYSIS PATIENTS Jai Won Chang,1 Jeong Ik Lee,1 Sang Hyun Kim,1 Soon Bae Kim,1 Kyu Bok Choi,2 Han Sun Cho,3 Jae Young Kang.4 1Internal Medicine, Univ.of Ulsan; 2Internal Medicine, Ewha Women’s Univ., Seoul; 3Dr. Cho’s Dialysis Clinic, Suwon; 4Sejong Hospital, Buchon, Korea

W677 IMPORTANT NUTRITIONAL AND CARDIOVASCULAR IMPLICATIONS FOR PERITONEAL DIALYSIS PATIENTS WITH A PREVIOUS HISTORY OF VOLUME OVERLOAD Angela Yee-Moon Wang,1 John Sanderson,1 Mei Wang,1 Mandy Man-Mei Sea,2 Siu-Fai Lui,1 Philip Kam-Tao Li,1 Jean Woo.2 1Medicine & Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Hong Kong; 2Center for Nutritional Studies, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Hong Kong

450 POSTERS WEDNESDAY, JUNE 12

W678 SODIUM REMOVAL (NaR) IN PATIENTS UNDERGOING CAPD AND AUTOMATED PERITONEAL DIALYSIS (APD). A PROSPECTIVE STUDY Ana Rodríguez-Carmona, Miguel Pérez-Fontán, Pedro Villaverde, WEDNESDAY Rafael García-Naveiro, Francisco Valdés. Nephrology, Hospital Juan Canalejo, A Coruña, Spain

W679 CO-MORBIDITY INDEX REFLECTS ACTIVATION OF CHRONIC INFLAMMATORY PROCESS IN PERITONEAL DIALYSIS PATIENTS Tomasz Stompor,1 Simon J. Davies,2 Wladyslaw Sulowicz,1 Aldona Dembinska-Kiec,3 Katarzyna Janda,1 Barbara Tabor,1 Katarzyna Wojcik,1 Anna Zdzienicka,3 Eve Janusz-Grzybowska.1 1PD Unit, Chair and Department of Nephrology, Jagiellonian Univ, Cracow, Poland; 2Dept of Nephrology, North Staffordshire Hospital, NHS Trust, Stoke-on-Trent, United Kingdom; 3Chair of Clinical Biochemistry, Jagiellonian Univ, Cracow, Poland

451 WEDNESDAY, JUNE 12 POSTERS

PD: INFLAMMATION, NUTRITION

W680 IMPORTANT FACTORS ASSOCIATED WITH AN ELEVATED C- REACTIVE PROTEIN IN CONTINUOUS AMBULATORY PERITONEAL DIALYSIS PATIENTS Angela Yee-Moon Wang,1 John Sanderson,1 Jean Woo,2 Mei Wang,1 Mandy Man Sea,2 Philip Kam-Tao Li,1 Siu-Fai Lui.1 1Medicine & Therapeutics, Prince of Wales Hospital, Chinese Univ. of Hong Kong, Hong Kong; 2Center for Nutritional Studies, Prince of Wales Hospital, Chinese Univ. of Hong Kong, Hong Kong

W681 ROSIGLITAZONE IMPROVES GLUCOSE METABOLISM IN NON- DIABETIC URAEMIC PATIENTS ON CONTINUOUS AMBULATORY PERITONEAL DIALYSIS Shih-Hua Lin,1 Shi-Wen Kuo,2 Yu-Juei Hsu,1 Yuh-Feng Lin.1 1Div. of Nephrology, 2Division of Endocrinology and Metabolism, Dept of Medicine, Tri-Service General Hospital, Taipei, Taiwan

W682 A ROLE OF ESTIMATION OF CARCINOMA ANTIGEN-125 (CA- 125) AND INTERLEUKIN-15 (IL-15) IN SERUM OF PATIENTS UNDERGOING PERITONEAL DIALYSIS (PD) Alicja Grzegorzewska, Monika Mlot, Magdalena Leander. Chair and Department of Nephrology, Transplantology and Internal Diseases, University of Medical Sciences, Poznan, Poland

W683 EFFECTIVE HOMOCYSTEINE-LOWERING THERAPY IN PERITONEAL DIALYSIS PATIENTS Marco Righetti,1 Adalberto Tommasi,1 Cinzia Lagona,1 Lucia La Rosa,2 Mario Uccellini,2 Adalberto Sessa.1 1U.O.C. di Nefrologia e Dialisi, Osp.“Civile” di Vimercate, Vimercate, Milano, Italy; 2Servizio Immunoematologia e Med. Trasfusionale, Ospedale “Civile” di Vimercate, Vimercate, Milano, Italy

W684 PERITONEAL DIALYSIS SOLUTIONS INHIBIT DENDRITIC CELL MATURATION: EFFECT OF LACTATE Rafael Selgas, Amaya Puig-Corver, M.-Auxiliadora Bajo, Jose-A. Sanchez-Tomero, Vicente Alvarez, Gloria del Peso, P. Sanchez- Mateos, Clifford Holmes, D. Faict, Angel Corbí. 1Nephrology, Hosp. Univ la Princesa, Madrid, Spain; 2Nephrology, Hosp Univ La Paz, Madrid, Spain; 3CSIC, Madrid, Spain; 4Baxter, Chicago, IL, United States

W685 DISFUNCTION OF PERITONEAL PHAGOCYTES RESPIRATORY BURST IN URAEMIC PATIENTS Piotr Kubit,1 Kamil Gotfryd,2 Adam Markiewicz,1 Olgierd Smolenski,1 Bohdan Turyna.2 1Department of Nephrology and Dialysis, Rydygier Hospital, Krakow, Poland; 2Department of Biotechnology, Jagiellonian University, Krakow, Poland

W686 PERITONEAL DIALYSATE CONTAINING A HIGH GLUCOSE SOLUTION ELEVATES SERUM LEPTIN LEVELS IN ACUTE URAEMIC RATS Keisuke Matsubara,1 Hideyasu Kiyomoto,1 Kumiko Moriwaki,1 Takatomi Shokoji,1 Hirofumi Hitomi,1 Naoki Kondo,1 Yasuharu Aki,1 Hiroshi Fujioka,1 Norihiro Takahashi,1 Akira Nishiyama,2 Megumu Fukunaga,3 Yoshihide Fujisawa,4 Shigekazu Yuasa,5 Masakazu Kohno.1 1The Second Dept of Internal Medicine, Kagawa Medical Univ., Kita- gun, Kagawa, Japan; 2Pharmacology, Kagawa Medical Univ., Kita- gun, Kagawa, Japan; 3Integrated Medicine, Kagawa Medical Univ., Kita-gun, Kagawa, Japan; 4Research Equipment Center, Kagawa Medical Univ., Kita-gun, Kagawa, Japan; 5Dept of Medical Technology, Kagawa Prefectural College of Health Sciences, Kita- gun, Kagawa, Japan

452 POSTERS WEDNESDAY, JUNE 12

W687 INCREASED LEVEL OF APOPTOTIC CD95+(Fas) AND ACTIVATED CD25+(IL-2RI) PERIPHERAL MONONUCLEAR CELL (PMC) IN PATIENTS WITH ESRD TREATED WITH PERITONEAL DIALYSIS WEDNESDAY Inese Mihailova,1 Aivars Petersons,1 Viktorija Mihailova,1 Inta Jaunalksne,2 Viktorija Priedite.2 1Nephrology Centre, P. Stradins Clinical University Hospital, Riga, Latvia; 2Latvian Centre of Clinical Immmunology, P. Stradins Clinical University Hospital, Riga, Latvia

W688 ANALYSIS OF THE FACTORS DETERMINING THE CHANGES OF LEAN BODY MASS AND FAT MASS IN CAPD PATIENTS DURING FIRST ONE YEAR Junyoung Do, Donghan Kim, Kyuhyang Cho, Jongwon Park, Kyungwoo Yoon. Department of Internal Medicine, Yeungnam University Hospital, Daegu, Republic of Korea

W689 LEPTIN (Lp), RESTING ENERGY EXPENDITURE (REE) AND BODY COMPOSITION OF PERITONEAL DIALYSIS (DP) PATIENTS – RELATIONSHIP WITH OBESITY? Cristina Martins,3 Cyntia Leinig,1 Miguel Carlos Riella,1 Luiz Felipe Goncalves,3 Roseana Fuerbringer,1 Percegona Luciana.1 1Nephrology, Clinica de Doencas Renais, Curitiba, Parana, Brazil; 2Nephrology, Pro-Renal Foundation, Curitiba, Parana, Brazil; 3Nephrology, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

W690 INTERCELLULAR ADHESION MOLECULE-1 RELATES TO INFLAMMATION AND CAROTID ATHEROSCLEROSIS IN PERITONEAL DIALYSIS PATIENTS Aikaterini Papagianni,1 Elisavet Kokolina,1 Michalis Kalovoulos,2 Andreas Vainas,1 Dimitrios Daravingas,2 Chrisostomos Dimitriadis,1 Dimitrios Memmos.1 1University Department of Nephrology, Hippokration General Hospital, Thessaloniki, Greece; 2Department of Radiology, Hippokration General Hospital, Thessaloniki, Greece

W691 ASSOCIATION BETWEEN THE PERITONEAL TRANSPORT RATE AND SYSTEMIC INFLAMMATION MARKERS IN CONTINUOUS AMBULATORY PERITONEAL DIALYSIS (CAPD) Alfonso M. Cueto-Manzano,1 Mario Salazar,1 Isela Valera- Gonzalez,1 Enrique Rojas-Campos,1 Ramon Martinez-Ramirez,1 Laura Cortes-Sanabria,1 Guillermo Rosales,2 Francisco Monteon.2 1Unidad de Investigacion Medica en Epidemiologia Clinica, Hospital de Especialidades, CMNO, IMSS, Guadalajara, Jalisco, Mexico; 2Depto. de Nefrología, Hospital de Especialidades, CMNO, IMSS, Guadalajara, Jalisco, Mexico

W692 PROCALCITONIN (PCT) - A NEW MARKER OF MICROINFLAMMATION IN PATIENTS TREATED BY PERITONEAL DIALYSIS (PD) Sylvie Opatrna,1 Jan Klaboch,1 Lubos Holubec, Jr.,2 Martina Tomsu,1 Frantisek Sefrna,1 Karel Opatrny, Jr.,1 Ondrej Topolcan.2 1Medicine I, Charles University Medical School, Pilsen, Czech Republic; 2Medicine II, Charles University Medical School, Pilsen, Czech Republic

W693 PERITONEAL PERMEABILITY AND INFLAMMATORY RESPONSE IN MALNOURISHED RATS Krzysztof Pawlaczyk,1,2 Malgorzata Kuzlan-Pawlaczyk,1 Alicja Polubinska,1 Soner Duman,1 Stanislaw Czekalski,1 Bengt Lindholm,2 Andrzej Breborowicz.1 1Department of Pathophysiology and Nephrology, University of Medical Sciences in Poznan, Poznan, Poland; 2Divisions of Baxter Novum and Renal Medicine, Karolinska Institutet, Stockholm, Sweden

453 WEDNESDAY, JUNE 12 POSTERS

W694 EFFECT OF NUTRINEAL ON THE INTRAPERITONEAL INFLAMMATORY RESPONSE AND PERITONEAL PERMEABILITY IN MALNOURISHED RATS ON CHRONIC PERITONEAL DIALYSIS (CPD) Malgorzata Kuzlan-Pawlaczyk,1 Krzysztof Pawlaczyk,1,2 Soner Duman,1 Alicja Polubinska,1 Stanislaw Czekalski,1 Bengt Lindholm,2 Andrzej Breborowicz.1 1Department of Pathophysiology and Nephrology, University of Medical Sciences in Poznan, Poznan, Poland; 2Divisions of Baxter Novum and Renal Medicine, Karolinska Institutet, Stockholm, Sweden

W695 PERITONEAL RECRUITMENT OF LEUKOCYTES AFTER SURGICAL INJURY – EFFECT OF THE PROCEDURES PREVENTING FORMATION OF ADHESION Jacek Karon,1 Malgorzata Kuzlan-Pawlaczyk,1 Krzysztof Pawlaczyk,1,2 Alicja Polubinska,1 Bengt Lindholm,2 Andrzej Breborowicz.1 1Department of Pathophysiology, University of Medical Sciences in Poznan, Poznan, Poland; 2Divisions of Baxter Novum and Renal Medicine, Karolinska Institutet, Stockholm, Sweden

W696 RELATIONSHIP BETWEEN PERITONEAL EQUILIBRATION TEST AND SURFACE TENSION OF PERITONEAL EFFLUENT IN CAPD PATIENTS Maria Majdan,1 Radoslaw Jeleniewicz,1 Ewa Krzyzanowska,1 Marek Majdan.2 1Department of Nephrology, University Medical School, Lublin, Poland; 2Department of Inorganic Chemistry, University of Maria Sklodowska-Curie, Lublin, Poland

W697 SUBMESOTHELIAL FIBROSIS IN PERITONEAL DIALYSIS RESULTS IN A LOSS OF CD34 EXPRESSION BY FIBROBLASTIC STROMAL CELLS Jose A. Jimenez-Heffernan,1 Rafael Selgas,2 M. Auxiliadora Bajo,3 Gloria Del Peso,3 Carlos Gamallo,4 Abelardo Aguilera,2 Jose A. Sanchez-Tomero,2 Manuel Lopez-Cabrera.5 1Department of Pathology, University Hospital, Guadalajara, Spain; 2Department of Nephrology, Hospital La Princesa, Madrid, Spain; 3Department of Nephrology, Hospital La Paz, Madrid, Spain; 4Department of Pathology, Hospital la Princesa, Madrid, Spain; 5Department of Molecular Biology, Hospital la Princesa, Madrid, Spain.

454 POSTERS WEDNESDAY, JUNE 12

PD: MISCELLANEOUS

W698 CAN ANURIC PATIENTS BE SUCCESSFULLY TREATED BY APD? WEDNESDAY RESULTS OF EAPOS (EUROPEAN APD OUTCOME STUDY) Werner Riegel,1 Edwina A. Brown,2 Simon J. Davies,3 Peter Rutherford,4 Frederique Meeus,5 Merce Borras,6 Jose C. Divino Filho,7 Ed Vonesh,8 Monique Van Bree.7 1Medizinische Klinik III, Klinikum Darmstadt, Darmstadt, Germany; 2Renal, Charing Cross Hospital, London, United Kingdom; 3Renal, North Staffordshire Hospital, Stoke-on-Trent, United Kingdom; 4Renal, Wrexham Maelor Hospital, Clwyd, United Kingdom; 5Renal, Centre Hospitalier Louise Michel Evry, Evry, France; 6Renal, Hospital Arnau de Vilanova, Lerida, Spain; 7Renal, Baxter Healthcare, Brussels, Belgium; 8Renal, Baxter Healthcare, Deerfield, IL, United States

W699 SEVEN YEARS OF CAPD IN ROMANIA: A LARGE REGIONAL SINGLE CENTER EXPERIENCE Laura Florea, Adrian Covic, Traian Taranu, Irina Buhaescu, Maria Covic. Dialysis and Transplantation, University Hospital “C. I. Parhon”Iasi, Romania

W700 COMPARISON OF PD MODALITY TECHNIQUE SURVIVAL IN INCIDENT PATIENTS, BETWEEN UK RENAL UNITS THAT MAKE HIGH AND LOW USE OF PD: DATA FROM THE UK RENAL REGISTRY Terry Feest,1 David Ansell,1 Richard Burden,2 Dirk van Schalkwyk.1 1UK Renal Registry, Southmead Hospital, Bristol, United Kingdom; 2Renal Unit, Nottingham City Hospital, Nottingham, United Kingdom

W701 A NEW SCINTIGRAPHIC TECHNIQUE TO EVALUATE THE INTRAPERITONEAL CAVITY DISTRIBUTION OF DIALYSIS SOLUTION IN PATIENTS UNDERGOING PERITONEAL DIALYSIS Bruno Memoli,1 Rosamunda D’Arcangelo,1 Giuseppina Romano,1 Luigi Celentano.2 1Dept of Nephrology, University “Federico II”Naples, Italy; 2Dept of Biomorphological Sciences, University “Federico II”Naples, Italy

W702 ENTIRELY LAPAROSCOPIC PLACEMENT OF PERITONEAL- DIALYSIS-CATHETERS A. Kribben,1 C. Jürgens,1 K.-E. Bonzel,2 T. Philipp,1 M.K. Walz,3 K. Peitgen.3 1Dept. of Nephrology, 2Dept. of Pediatric Nephrology, University of Essen, Essen, Germany; 3Dept. of Surgery and Center for Minimally Invasive Surgery, Ev. Huyssens-Stiftung, Essen, Germany

W703 CLINICAL OUTCOMES OF PHYSICIAN PLACED TENCKHOFF CATHETERS: A REVIEW OF CONSECUTIVE 134 CATHETERS OVER 2 YEARS Anthony Tang, Yiu Ho, Sydney Tang. Division of Nephrology, Department of Medicine, United Christian Hospital, Kwun Tong, Kowloon, Hong Kong

W704 THE ISOLATION OF ANOREXIA ASSOCIATED URAEMIC TOXINS FROM EFFLUENT OF CAPD PATIENTS Zhi-Hua Zheng,1 Björn Anderstam,2 Olof Heimburger,2 Bengt Lindholm.2 1Dept.of Nephrology,the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China; 2Divisions of Baxter Novum and Renal Medicine, Huddinge Hospital, Karolinska Institute, Stockholm, Sweden

455 WEDNESDAY, JUNE 12 POSTERS

W705 CHRONIC PERITONEAL DIALYSIS TREATMENT DOES NOT REDUCE GASTROINTESTINAL LIFE-QUALITY COMPARED TO HAEMODIALYSIS TREATMENT Gunnar Heine, Chantal Kastner, Thomas Jahnke, Hans Kohler, Martin Kuhlmann. Nephrology, University of Homburg, Homburg, Saarland, Germany

W706 COMBINATION OF PERITONEAL DIALYSIS (PD) AND HAEMODIALYSIS (HD) IMPROVES SOLUTE CLEARANCE AND QUALITY OF LIFE FOR UNDERDIALYZED PD PATIENTS Y.L. Cheng, C.U. Yung, Y.T. Tsui, C.K. Wong, K.Y. Tsang, Alex W. Yu. Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China

W707 CAPD IS ASSOCIATED WITH STIFFER ARTERIES AND MORE ABNORMAL NO-DEPENDENT ENDOTHELIAL VASOMOTOR FUNCTION Adrian Covic,1 David Goldsmith,2 Laura Florea,1 Paul Gusbeth- Tatomir,1 Maria Covic.1 1Dialysis and Transplantation, University Hospital “C. I. Parhon, Ïasi, Romania; 2Renal Unit, Guy’s Hospital, London, United Kingdom

W708 A NEW PD CONNECTION SYSTEM THAT REDUCES THE RISK OF TOUCH CONTAMINATION: VALIDATION OF THE INTEGRITY OF THE SELF-SEALING SEPTUM Winnie Kubey, Paul Straka, Cliff Holmes, Brian Connell. Renal Div. Baxter Healthcare Corporation, McGaw Park, IL, USA

W709 CLINIC PREDIALYSIS PATIENT SITUATION CONDITIONS DIALYSIS MODALITY CHOICE Mayte E. Rivera, Ana M. Tato, Jose L. Merino, Minerva Arambarri, Rocío Echarri, Carmen Alarcón, Jose L. Teruel, Milagros Fernández- Lucas, Joaquín Ortuño. Nephrology, Hospital Ramón y Cajal, Madrid, Spain

W710 CAPD AND APD - DOES TREATMENT MODALITY INFLUENCE CHARACTERISTICS OF THE PERITONEAL MEMBRANE? Alena Parikova,1 Machteld M. Zweers,1 Dirk G. Struijk,1,2 Raymond T. Krediet.1 1Department of Nephrology, Academic Medical Center University of Amsterdam, Amsterdam, NH, Netherlands; 2Dianet Foundation, Amsterdam-Utrecht, NL, Netherlands

W711 INFLUENCE OF CONTINUOUS AMBULATORY PERITONEAL DIALYSIS (CAPD) ON THE KINETICS OF ORAL MOXIFLOXACIN (MXF) Anna Mitchell,1 Sandra Bührmann,1 Heino Stass,2 Dagmar Kubitza,2 Jan-Georg Möller,2 Rafael F. Schäfers.2 1Clinic for Nephrology & Hypertension, Essen University Hospital, Essen, NRW, Germany; 2Pharma Research Center, Bayer AG, Wuppertal, NRW, Germany

W712 FLUID OVERLOAD IN CONTINUOUS AMBULATORY PERITONEAL DIALYSIS (CAPD) PATIENTS Jie Dong, Li-jia Zhao, Tao Wang. Institute of Nephrology, First Hospital, Beijing, China

W713 EFFECT OF SALT AND WATER RESTRICTION ON FLUID STATUS IN DIABETIC PERITONEAL DIALYSIS PATIENTS Hong-bing Gan, Meng-hua Chen, Tao Wang. Institute of Nephrology, First Hospital, Peking University, Beijing, China

456 POSTERS WEDNESDAY, JUNE 12

W714 THE EFFECTS OF TAMOXIFEN AND CYCLOSPORINE ON DIALYSATE CYTOKINES PROFILE IN HYPERTONIC PD SOLUTION INDUCED RATS Soner Duman,1 Sait Sen,2 Can Duman,3 Bilgin Arda,4 Huseyin Toz,1 WEDNESDAY Ercan Ok,1 Fehmi Akcicek,1 Ali Basci.1 1Nephrology, Ege University, Izmir, Turkey; 2Pathology, Ege University, Izmir, Turkey; 3Biochemistry, Kocaeli University, Kocaeli, Turkey; 4Clinical Bacteriology and Infectious Disease, Ege University, Izmir, Turkey

W715 SAMPLING OF PERITONEAL INTERSTITIAL FLUID AND MEASUREMENTS OF COLLOID OSMOTIC PRESSURES AFTER PERITONEAL DIALYSIS IN RATS Bert-Inge Rosengren,1,2 Bengt Rippe,1 Olav Tenstad,2 Helge Wiig.2 1Department of Nephrology, Lund University, Lund, Sweden; 2Department of Physiology, University of Bergen, Bergen, Norway

W716 IMPORTANT DIFFERENTIATION OF FACTORS PREDICTING OUTCOME IN ANURIC AND NON-ANURIC PERITONEAL DIALYSIS PATIENTS - A PROSPECTIVE STUDY Angela Yee-Moon Wang,1 John Sanderson,1 Jean Woo,2 Mei Wang,1 Mandy Man Sea,2 Siu-Fai Lui,1 Philip Kam-Tao Li.1 1Medicine & Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, Hong Kong; 2Center for Nutritional Studies, Prince of Wales Hospital, Chinese University of Hong Kong., Hong Kong, Hong Kong

W717 SOLUBLE CD-146 AND OTHER MARKERS OF ENDOTHELIAL CELL INJURY ARE ELEVATED IN PERITONEALLY DIALYZED AND NEPHROTIC PATIENTS Jolanta Malyszko, Jacek Malyszko, Michal Mysliwiec. Nephrology and Internal Medicine, Medical University, Bialystok, Podlaskie, Poland

W718 LOW SODIUM DIALYSATE (LNa, 102 mEq/l) IMROVES BLOOD PRESSURE CONTROL AND WATER AND SODIUM BALANCE ON THE LONG TERM IN PERITONEAL DIALYSIS (PD) PATIENTS WITH ULTRAFILTRATION FAILURE (UFF) François Vrtovsnik,1 Gilles Hufnagel,1 Catherine Michel,1 Marie Essig,1 Nadia Sedrati,1 Alain Boulier,2 Latifa Azeroual,1 Françoise Mignon.1 1Nephrology, Xavier Bichat Hospital, Paris, France; 2Physiology, Xavier Bichat Hospital, Paris, France

W719 DIALYSIS WITHDRAWAL IN A LARGE PERITONEAL DILAYSIS POPULATION Sally Santacroce,1,2 Peter Juergensen,1,2,3 Diane Wuerth,1,2 Alan Kliger,1,2,3 Fredric Finkelstein.1,2,3 1Medicine, New Haven CAPD, New Haven, CT, United States; 2Medicine, Renal Research Institute, New York, NY, United States; 3Medicine, Yale School of Medicine, New Haven, CT, United States

W720 RESTLESS LEG SYNDROME (RLS): A NOVEL MARKER FOR RESIDUAL RENAL FUNCTION (RRF) AND MORTALITY IN END- STAGE RENAL DISEASE (ESRD) Teresa Y.H. Wong, David S.C. Hui, Cheuk Chun Szeto, Fanny W.S. Ko, Philip K.T. Li. Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong

457 WEDNESDAY, JUNE 12 POSTERS

TRANSPLANTATION: TRANSPLANTATION: IMMUNOSUPPRESSION - CLINICAL TRIALS

W721 PREVALENCE AND IMPACT OF OVERT AND COVERT DUPLICATE PUBLICATION OF RANDOMISED TRIALS IN RENAL TRANSPLANTATION Angela Webster,1,2,3 Jeremy Chapman,2,3 Jonathan Criag.1,2 1Centre for Kidney Research, Children’s Hospital, Westmead, NSW, Australia; 2Faculty of Medicine, University of Sydney, Sydney, NSW, Australia; 3Department of Renal Medicine, Westmead Hospital, Westmead, NSW, Australia

W722 CALCINEURIN-INHIBITOR NEPHROTOXICITY AND EFFICACY STUDY: THE CANNES TRIAL Eduard Scholten,1 Ajda Rowshani,2 Janto Surachno,2 Erik van Kan,3 Serge Cremers,4 Leendert Paul,1 Ineke ten Berge,2 Hans de Fijter.1 1Nephrology, Leiden University Medical Center, Netherlands; 2Nephrology, Amsterdam Medical Center, Netherlands; 3Clinical Pharmacy and Toxicology, AMC, Amsterdam, Netherlands; 4Clinical Pharmacy and Toxicology, LUMC, Leiden, Netherlands

W723 CO-ADMINISTRATION OF KETOCONAZOLE AND CYCLOSPORINE FOR KIDNEY TRANSPLANT PATIENTS: 10 YEAR FOLLOW-UP OF A PROSPECTIVE RANDOMIZED STUDY Amgad El-Agroudy, Mohamed A. Sobh, Ahmed Hamdy, Mohamed Ahmed Ghoneim. Nephrology, Urology & Nephrology Center, Mansoura, DK, Egypt

W724 USING OF KETOCONAZOLE FOR CYCLOSPORINE A DOSE REDUCTION IN RENAL TRANSPLANTATION Yelena Prokopenko, Evgeniya Scherbakova, Andrey Vatazin, Sergey Pasov, Vladimir Suslov. Department of Chronical Dialysis and Kidney Transplantation, Moscow Regional Research Clinical Institute, Moscow, Russian Federation

W725 COMPARISON OF C2 MONITORIZED CYCLOSPORINE AND TACROLIMUS BASED IMMUNOSUPPRESSIVE REGIMENS IN RENAL TRANSPLANT RECIPIENTS Murat Tuncer,1 Serdar Kacar,2 Asuman Yavuz,1 Ramazan Cetinkaya,1 Sabri Tekin,2 Alihan Gurkan,2 Alper Demirbas,2 Mustafa Akaydin,2 Gulsen Yakupoglu,1 Fevzi Ersoy.1 1Medicine, Akdeniz University, Antalya, Turkey; 2General Surgery, Akdeniz University, Antalya, Turkey

W726 IMPROVED EFFICACY AND TOLERABILITY OF NEORAL BY C2- MONITORING IN DE NOVO RENAL TRANSPLANT RECIPIENTS Matthias Buchler,1 Steven Chadban,2 Aurelio Rodriguez,2 Luis Jost,2 Markus Weber,2 Edward Cole.2 1Nephrologie, Hopital Bretonneau, CHRU, Tours, France; 2on Behalf of the MO2ART Study Group

W727 CYCLOSPORINE C2 MONITORING IN LONG-TERM RENAL TRANSPLANT RECIPIENTS WITH STABLE GRAFT FUNCTION Kuo-Hsiung Shu, Ming-Ju Wu, Cheng-Hsu Chen, Chi-Hung Cheng, Kuo- Jong Chen. Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

458 POSTERS WEDNESDAY, JUNE 12

W728 A C2 -CONCENTRATION OF 700-800µg/L IS ASSOCIATED WITH A BETTER GRAFT FUNCTION IN LONG TERM RENAL TRANSPLANT RECIPIENTS Karsten Midtvedt,1 Per Fauchald,1 Stein Bergan,1 Einar Svarstad,2 WEDNESDAY Aud Høieggen,2 Stein Hallan,2 Harald Bergrem,2 Bjørn O. Eriksen,2 Ingvild Dalen,1 Torbjørn Leivestad.1 1Nephrology Dept., National Hospital, Oslo, Norway; 2the NOR2HEIM Study Group

W729 CYCLOSPORIN C2-LEVELS ARE NOT RELATED TO SIDE EFFECTS OF IMMUNOSUPPRESSION AFTER KIDNEY TRANSPLANTATION Kai Lopau, Rebekka Schwarz, Ekkehard Heidbreder, Christoph Wanner. Internal Medicine, Division of Nephrology, University Hospital Wuerzburg, Wuerzburg, Germany

W730 LONG-TERM IMMUNOLOGICAL EFFECTS OF ATG INDUCTION THERAPY IN RENAL ALLOGRAFT RECIPIENTS Rolf Weimer,1 Sevgi Yildiz,1 Anne Staak,1 Hartmut Dietrich,1 Volker Daniel,2 Lucy Reiner,1 Andreas Feustel,1 Shirin Kamali-Ernst,3 Wolfgang Ernst,3 Winfried Padberg,4 Gerhard Opelz.2 1Department of Internal Medicine, University of Giessen, Giessen, Germany; 2Institute of Immunology, University of Heidelberg, Heidelberg, Germany; 3Dialysis Centers, Wetzlar and Langenselbold, Germany; 4Department of Surgery, University of Giessen, Giessen, Germany

W731 PATTERNS OF ADMINISTRATION OF ANTIBODY INDUCTION THERAPY AND THEIR ASSOCIATED OUTCOMES IN CADAVERIC RENAL TRANSPLANTATION IN THE UNITED STATES Suphamai Bunnapradist,1 Adarsh Daswani,1 Stanley Jordan,1 Alice Peng,1 Steven Takemoto.2 1Multi-Organ Transplant, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, CA, United States; 2Dumont Liver Transplant Program, UCLA School of Medicine

W732 PATTERNS OF ADMINISTRATION OF ANTIBODY INDUCTION THERAPY AND THEIR ASSOCIATED OUTCOMES IN LIVE DONOR RENAL TRANSPLANTATION IN THE UNITED STATES Suphamai Bunnapradist,1 Adarsh Daswani,1 Alice Peng,1 Stanley Jordan,1 Steven Takemoto.2 1Muti-Organ Transplant Program, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, CA, USA; 2Dumont Liver Transplant Progam, UCLA Medical Center, Los Angeles, CA, USA

W733 THE EFFECT OF MYCOPHENOLATE MOFETIL ON SLOWING THE PROGRESSION OF CHRONIC RENAL ALLOGRAFT DYSFUNCTION Ahad J. Ghods, Dariush Nasrollahzadeh. Transplantation Unit, Hashemi Nejad Kidney Hospital, Tehran, Iran

W734 STABLE RENAL TRANSPLANT PATIENTS ON MYCOPHENOLATE MOFETIL CAN BE SAFELY SWITCHED TO ENTERIC-COATED MYCOPHENOLATE SODIUM: 12-MONTH DATA OF A PROSPECTIVE RANDOMIZED TRIAL Klemens Budde,1 John Curtis,2 Gregory Knoll,3 Lawrence Chan,4 Hans Neumayer,1 Charlotte Panis,5 Yodit Seifu,5 Michael Hall.5 1Zentrum fuer Innere Medizin-Nephrologie, Universitaetsklinik Charite, Berlin, Germany; 2Div.of Nephrology, Univ. of Alabama at Birmingham, Birmingham, AL, USA; 3Nephrology Division, Ottawa General Hospital, Ottawa, ON, Canada; 4University of Colorado Health Science Center, Denver, CO, USA; 5The Myfortic Maintenance Renal Transplant Study Group, Tranplantation and Immunology Novartis Pharmaceutical Corporation, East Hanover, NJ, USA

459 WEDNESDAY, JUNE 12 POSTERS

W735 RESULTS FROM AN ONGOING, LONG-TERM EXTENSION STUDY COMPARING SIROLIMUS-BASED THERAPY USED WITH OR WITHOUT CYCLOSPORINE IN RENAL TRANSPLANT RECIPIENTS Jose M. Morales, Josep M. Campistol, Henri Kreis, Georges Mourad, Josette Eris, Francesco P. Schena, Josep M. Grinyo, Marco Castagneto. Renal Transplant Unit, Hosp. Univ. 12 de Octubre, Madrid, Spain

W736 LONG-TERM GRAFT SURVIVAL IS SIGNIFICANTLY BETTER IN PATIENTS RECEIVING SIROLIMUS-BASED THERAPY AFTER EARLY CYCLOSPORINE WITHDRAWAL Josep M. Campistol, Rainer Oberbauer, Anders Hartmann, Henri Kreis, Alfredo Mota, Manuel Arias, Antonio C. Henriques, Jeremy Chapman, the Rapamune Maintenance Regimen Study Group. Unidad de Transplante Renal, Hosp. Clinic i Provincial, Barcelona, Spain

W737 A MODEL USED TO PREDICT 10-YEAR GRAFT SURVIVAL SHOWS BETTER OUTCOME WITH SIROLIMUS-BASED THERAPY Josep M. Campistol, Rainer Oberbauer, Yves Brault, James T. Burke. Unidad de Transplante Renal, Hosp. Clinic i Provincial, Barcelona, Spain

W738 AN OPEN-LABEL STUDY TO EVALUATE THE EFFICACY & SAFETY OF CYCLOSPORINE REDUCTION IN DE NOVO RENAL ALLOGRAFT RECIPIENTS RECEIVING SIROLIMUS: A DOSE COMPARATIVE STUDY H.H. Neumayer,1 F. Muehlbacher,2 D. del Castillo,3 S. Stefoni,4 the European Sirolimus CsA Minimisation Study Group. 1Dept of Nephrology, Universitatsklinikum Charite-Mitte, Berlin, Germany; 2Univ. Clinic of Surgery, Vienna, Austria; 3Hosp.Reina Sofia, Cordoba, Spain; 4Azienda Osp. S. Orsola, Malphigi, Bologna, Italy

W739 AN OPEN-LABEL, CONCENTRATION-CONTROLLED, RANDOMISED 6-MONTH STUDY OF STANDARD-DOSE TACROLIMUS + SIROLIMUS + STEROIDS COMPARED TO REDUCED-DOSE TACROLIMUS + SIROLIMUS + STEROIDS IN RENAL ALLOGRAFT RECIPIENTS W.O. Bechstein,1 L. Paczek,2 L. Wramner,3 J.P. Squifflet,4 the European Sirolimus Tacrolimus Study Group. 1Dept of Surgery, Ruhr-Univ., Bochum, Germany; 2Clinic of Immunotherapy and Internal Diseases, Inst. of Transplantation, Warsaw, Poland; 3Sahlgrenska Univ. Hosp., Goteborg, Sweden; 4Saint Luc Hosp., Brussels, Belgium

W740 EXCELLENT RENAL FUNCTION WITH CONCENTRATION- CONTROLLED EVEROLIMUS, REDUCED EXPOSURE TO NEORAL®, AND STEROIDS IN DE NOVO KIDNEY TRANSPLANT RECIPIENTS: RESULTS OF A 6 MONTHS EFFICACY AND SAFETY ANALYSIS Julio Pascual,1 Helio Tedesco,2 Giovanni Civati,3 John Magee,4 Tomas Haas,5 Peter Bernhardt.5 1Serv. de Nefrologia, Hosp. Ramon y Cajal, Madrid, Spain; 2Div. of Nephrology, Hosp. do Rim e Hipertensao, Sao Paulo, Brazil; 3Divisione Nefrologia e Dialisi, Az Osp. Niguarda Ca’Grande, Milano, Italy; 4Taubmann Center, Univ.of Michigan Medical Center, Ann Arbor, MI, USA; 5Business Unit Transpl., Novartis Pharma AG, Basel, Switzerland

W741 EXCELLENT GRAFT FUNCTION IN DE NOVO KIDNEY TRANSPLANT RECIPIENTS TREATED WITH CONCENTRATION CONTROLLED EVEROLIMUS, REDUCED NEORAL EXPOSURE AND BASILIXIMAB: 6 MONTHS ANALYSIS Bernhard K. Krämer,1 John Whelchel,2 Josette Eris,3 Scott Campbell,4 Stefan Vitko,5 Tomas Haas,6 Annette Jappe for the 2307 Study Group.6 1Int. Med. II – Nephrology, Univ. of Regensburg, Regensburg, Germany; 2Organ Transpl. Services, Piedmont Hosp., Atlanta, GA, USA; 3Renal Unit, Royal Prince Alfred Hosp., Camperdown, Australia; 4Dept of Renal Medicine, Princess Alexandra Hosp., Woollongabba, Australia; 5Transpl. Center, Inst. of Clinical and Exp.Med., Praha, Czech Republic; 6Business Unit Transpl., Novartis Pharma AG, Basel, Switzerland

460 POSTERS WEDNESDAY, JUNE 12

W742 RENAL TRANSPLANT PATIENTS WITH RISK FACTORS FOR REDUCED RENAL FUNCTION BENEFIT FROM CYCLOSPORINE WITHDRAWAL AND SIROLIMUS MAINTENANCE THERAPY Rainer Oberbauer, Alfredo Mota, Dolores Prats, Timothy Mathew, WEDNESDAY Jose M. Morales, Pierre Daloze, Manuel Arias, Bernard Bourbigot, the Rapamune Maintenance Regimen Study Group. Nephrology, Allgemeines Krankenhaus, Vienna, Austria

W743 PATIENTS RECEIVING SIROLIMUS MAINTENANCE THERAPY HAVE BETTER RENAL FUNCTION AFTER EARLY CYCLOSPORINE WITHDRAWAL IRRESPECTIVE OF BASELINE RENAL FUNCTION: INTENT-TO-TREAT RESULTS AT 3 YEARS Anders Hartmann, Alfredo Mota, Christophe Legendre, Giuseppe Segoloni, Josep M. Grinyo, Brian Hutchison, Jose M. Morales, Paolo Altieri, Javier Martinez, Tim Mathew, the Rapamune Maintenance Regimen Study Group. Nephrology, Rikshospital, Oslo, Norway

W744 IMPROVEMENT OF KIDNEY TRANSPLANT FUNCTION ONE YEAR AFTER CONVERSION FROM CALCINEURIN-INHIBITOR (CNI) TO SIROLIMUS (SRL) IN PATIENTS WITH CHRONIC CNI NEPHROTOXICITY AND LOW PROTEINURIA Fritz Diekmann,1 Klemens Budde,1 Jose Torregrosa,2 Federico Oppenheimer,2 Lutz Fritsche,1 Hans Neumayer,1 Josep Campistol.2 1Nephrology, Charitè Campus Mitte, Berlin, Germany; 2Unidad de Trasplante Renal, Hospital Clinico, Barcelona, Cataluña, Spain

W745 ABSENCE OF REJECTION AND STABLE SERUM CREATININE ARE EXCELLENT CRITERIA FOR STEROID-WITHDRAWAL IN KIDNEY TRANSPLANT PATIENTS RECEIVING TACROLIMUS TREATMENT Leszek Paczek, Z. Wlodarczyk, F. Perner, S. Vitko, M. Ostrowski, P. Bachleda, F. Kokot, M. Klinger, P. Szenohradsky, P. Studenik, P. Navratil, L. Asztalos, B. Rutkowski, N. Kalmar Nagy, D. Hickey. Department of Immunology, Transplantology and Internal Diseases, Transplantation Institute, Warsaw, Poland

W746 RESULTS OF LATE CESSATION OF CORTICOSTEROIDS IN STABLE RENAL TRANSPLANT PATIENTS Bart Maes, Katleen Claes, Pieter Evenepoel, Dirk Kuypers, Yves Vanrenterghem. Department of Nephrology, UZ Gasthuisberg, Leuven, Belgium

W747 THE COMBINATION OF DACLIZUMAB, TACROLIMUS, AND MMF IS AN EFFECTIVE AND SAFE STEROID-FREE IMMUNOSUPPRESSIVE REGIMEN AFTER RENAL TRANSPLANTATION. RESULTS OF A LARGE MULTICENTRE TRIAL Diego Cantarovich, Lionel Rostaing, Georges Mourad, Hans-Helmut Neumayer, Paolo Rigotti, the Tacrolimus Steroidwithdrawal Study Group. Nephrology and Clinical Immunology Unit, Nantes University Hospital, Nantes, France

W748 LARGE, PROSPECTIVE STUDY EVALUATING STEROID-FREE IMMUNOSUPPRESSION WITH TACROLIMUS/BASILIXIMAB AND TACROLIMUS/MMF COMPARED WITH TACROLIMUS/ MMF/STEROIDS IN RENAL TRANSPLANTATION Marian Klinger,1 Stefan Vitko,2 Kaija Salmela,3 Zbigniew Wlodarczyk,4 Gunnar Tyden,5 the ATLAS Study Group. 1Department of Nephrology, Wroclaw Medical University, Wroclaw, Poland; 2Department of Nephrology, IKEM, Prague, Czech Republic; 3Department of Surgery, Helsinki University Hospital, Helsinki, Finland; 4Zespol Transplantacji Nerek, Wojewodzki Szpital Zespolony, Poznan, Poland; 5Huddinge University Hospital, Dept of Transplantation Surgery, Huddinge, Sweden

461 WEDNESDAY, JUNE 12 POSTERS

W749 TACROLIMUS AND LIPIDS IN KIDNEY TRANSPLANTATION. LONG TERM FOLLOW-UP Giuseppe Palmiero,1 Domenico Capone,2 Mario M. Balletta,1 Stefano Federico,1 Marialuigia Sirico,1 Mariangela Amato,1 Domenico Russo.1 1Nephrology, University of Naples, Naples, Italy; 2Neuroscience, University of Naples, Naples, Italy

W750 TACROLIMUS FOR RENAL TRANSPLANT RECIPIENTS: A META- ANALYSIS OF RANDOMISED TRIALS Angela Webster,1,2,3 Gail Higgins,1 Jeremy Chapman,2,3 Jonathan Craig.1,2 1Centre for Kidney Research, Children’s Hospital, Westmead, NSW, Australia; 2Faculty of Medicine, University of Sydney, NSW, Australia; 3Department of Renal Medicine, Westmead Hospital, NSW, Australia

462 POSTERS WEDNESDAY, JUNE 12

TRANSPLANTATION: IMMUNOSUPPRESSION - OTHER WEDNESDAY

W751 GRAFT SURVIVAL AND COST FOLLOWING GASTROINTESTINAL COMPLICATIONS IN RENAL TRANSPLANT RECIPIENTS TREATED WITH MYCOPHENOLATE MOFETIL Mark A. Schnitzler,1 Karen L. Hardinger,2 Daniel C. Brennan.1 1Transplantation, Barnes-Jewish Hospital at Washington University, St Louis, MO, United States; 2St Louis College of Pharmacy, St Louis, MO, United States

W752 PHARMACOKINETIC AND PHARMACODYNAMIC MONITORING OF RENAL ALLOGRAFT RECIPIENTS TREATED WITH MYCOPHENOLATE MOFETIL Petra Glander,1 Ingrid Mai,2 Pia Hambach,1 Kay-Patrick Braun,1 Johannes Waiser,1 Lutz Fritsche,1 Hans-Hellmut Neumayer,1 Klemens Budde.1 1Department of Nephrology, CharitéHumboldt University, Berlin, Germany; 2Institute of Clinical Pharmacology, CharitéHumboldt University, Berlin, Germany

W753 BAYESIAN ESTIMATION AND THERAPEUTIC DRUG MONITORING FOR CYCLOSPORINE A AND MYCOPHENOLATE MOFETIL Yannick Le Meur,1 Jean-Cristophe Szelag,1 Aurelie Premaud,2 Frank Saint-Marcoux,2 Jean Debord,2 Pierre Marquet.2 1Dept of Nephrology, Univ.Hospital, Limoges, France; 2Dept of Pharmacology and Toxicology, Univ. Hospital, Limoges, France

W754 LONG-TERM PHARMACOKINETICS OF MYCOPHENOLIC ACID (MPA) IN COMBINATION WITH TACROLIMUS AND CORTICOSTEROIDS: A 12-MONTH PROSPECTIVE STUDY IN ONE HUNDRED DE NOVO RENAL ALLOGRAFT RECIPIENTS Dirk R.J. Kuypers, Kathleen Claes, Pieter Evenepoel, Bart Maes, Yves Vanrenterghem. Dpt.Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium

W755 EARLY IMMUNOSUPPRESSION WITH RAPAMYCIN AFTER PROLONGED COLD ISCHEMIA MODIFIES THE OUTCOME OF CHRONIC ALLOGRAFT NEPHROPATHY I. Herrero-Fresneda,1 J. Torras,1,2 A. Vidal,3 N. Lloberas,1 J.M. Cruzado,1,2 J.M. Grinyo.1,2 1Lab. Exp. Nephrology, H.U.Bellvitge; 2Nephrology; 3Pathology Serv., H.U.Bellvitge, Barcelona, Spain

W756 FAVORABLE CARDIOVASCULAR RISK PROFILE IN RENAL TRANSPLANT PATIENTS RECEIVING SIROLIMUS MAINTENANCE THERAPY FOLLOWING CYCLOSPORINE WITHDRAWAL: 3-YEAR RESULTS OF THE RAPAMUNE MAINTENANCE REGIMEN TRIAL Anders Hartmann, Jose Colon, Joao Pena, Javier Martinez, Rowan Walker, Wolfgang Arns, Jose M. Morales, Francesco P. Schena, Rainer Oberbauer, the Rapamune Maintenance Regimen Study Group. Nyreseksjonen, Rikshospitalet, Oslo, Norway

W757 LYMPHOCYTE SUBSETS CHANGES WHEN RAPAMYCIN (RAPA) SUBSTITUTES FOR MYCOPHENOLATE MOFETIL (MMF) IN KIDNEY TRANSPLANTATION Jose Gerardo Oliveira,1 Tiago Guimarães,2 Paula Xavier,3 Conceição Magalhães,2 Susana Sampaio,1 Isabel Tavares,1 Jorge Candeias,2 Manuel Pestana.1 1Nephrology, Faculty Medicine - Hosp. S Joao, Porto, Portugal; 2Immunology, Faculty Medicine - Hosp. S Joao, Porto, Portugal; 3Tissue Typing, Porto, Portugal

463 WEDNESDAY, JUNE 12 POSTERS

W758 GENDER BASED IMMONOSUPPRESSION? DIFFERENT EFFECTS OF CYCLOSPORINE A (CsA) AND RAPAMYCIN (Rapa) ON RENAL ENDOTHELIAL AND NEURONAL NITRIC OXIDE SYNTHASE (eNOS and nNOS) EXPRESSION Attila Szabo,1,2 Veronika Muller,1,3 Aaron Erdely,1 Chris Baylis.1 1Physiology, West Virginia University, Morgantown, WV, United States; 2I. Dept. of Pediatrics, Semmelweis University, Budapest, Hungary; 3Pulmonology, Semmelweis University, Budapest, Hungary

W759 INFLUENCE OF SIROLIMUS ON HUMAN MESANGIAL CELL CHOLESTEROL HOMEOSTASIS:EVIDENCE FOR ITS ANTI- ATHEROSCLEROTIC EFFECT Zac Varghese, Ray Fernando, John F. Moorhead, Stephen H. Powis, Xiong Z. Ruan. Centre for Nephrology, Royal Free and University College Medical School, London, United Kingdom

W760 MARKED RED BLOOD CELL MICROCYTOSIS UNDER COMBINATION OF RAPAMYCIN AND MYCOPHENOLATE MOFETIL Min-Jeong Kim, Martina Pechula, Michael Mayr, Jürg Steiger, Michael Dickenmann. Transplant Immunology & Nephrology, University Hospital of Basel, Basel, Basel Stadt, Switzerland

W761 INCREASED INCIDENCE OF HYPERCHOLESTEROLEMIA IN RENAL TRANSPLANT RECIPIENTS RECEIVING SIROLIMUS Sali Aswad, Moses Spira, Hamid Shidban, Shirley Mirador, Robert Mendez. Transplantation, National Institute of Transplantation, Los Angeles, CA, United States

W762 EFFECTS OF CANDESARTAN ON GLOMERULAR HEMODYNAMICS AND PERMSELECTIVITY IN PATIENTS WITH STABLE RENAL ALLOGRAFT FUNCTION Gerd Ruediger Hetzel, Joerg Plum, Gerrit Schoenicke, Fedai Oezcan, Bernd Grabensee. Nephrology and Rheumatology, Universitaetsklinikum Duesseldorf, Duesseldorf, Germany

W763 THE EFFECTS OF ANTIOXIDANT VITAMINS E AND C ON THE LIPIDS -,LIPOPROTEINS- AND MALONDIALDEHYDES LEVEL IN RENAL TRANSPLANT RECIPIENTS Madjid Mortazavi, Mohammad Hossein Biglu, Mohammad RahbaniNobar, Mohammad Noori. Internal Medicine Section, Emam Hospital, Tabriz, East Azarbaijan, Iran

464 POSTERS WEDNESDAY, JUNE 12

TRANSPLANTATION: OUTCOMES, CARDIOVASCULAR MORBIDITY AND MORTALITY WEDNESDAY

W764 META-ANALYSIS OF POST-TRANSPLANTATION DIABETES MELLITUS (PTDM) IN PATIENTS RECEIVING CALCINEURIN INHIBITORS (CNI) Olaf Heisel,1,3 Rochelle Heisel,3 Rob Balshaw,2,3 Paul Keown.1,3 1Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; 2Statistics, Simon Fraser University, Vancouver, BC, Canada; 3Syreon Corp., Vancouver, BC, Canada

W765 KIDNEY FUNCTION AND GRAFT SURVIVAL IN COMBINED ISLET-KIDNEY-TRANSPLANTATION UNDER A GLUCOCORTICOID-FREE IMMUNOSUPPRESSIVE REGIMEN Peter Berthold,1 Patrice M. Ambuehl,1 Markus Weber,2 Giatgen Spinas,4 Thomas Pfammatter,3 Ulrich Binswanger,1 Roger Lehmann.4 1Nephrologie, Universitaetsspital, Zurich, Switzerland; 2Surgery, Universitaetsspital, Zurich, Switzerland; 3Radiology, Universitaetsspital, Zurich, Switzerland; 4Endocrinology, Universitaetsspital, Zurich, Switzerland

W766 STEROIDS WITHDRAWAL IN PRIMARY SIMULTANEOUS PANCREAS-KIDNEY (SPK) TRANSPLANTATION: RESULTS AT 1 YEAR OF A LARGE MULTICENTER TRIAL Andreas Kahl, Jacques Malaise, Wolfgang Steurer, EUROSPK Study Group. EUROSPK, EUROSPK Central Office, Brussels, Belgium

W767 COMPARABLE KIDNEY GRAFT SURVIVAL OF TYPE I DIABETICS TREATED WITH SIMULTANEOUS PANCREAS-KIDNEY TRANSPLANTATION (SPK) AND NON DIABETIC PATIENTS TREATED WITH CADAVERIC RENAL TRANSPLANTATION (KTX) Jan Henrik Hoerstrup,1 Andreas Kahl,1 Lutz Fritsche,2 Peter Neuhaus,3 Ulrich Frei.1 1Department of Nephrology and Medical Intensive Care, Charité - Campus Virchow Klinikum, Humboldt University, Berlin, Germany; 2Department of Nephrology, Charité - Campus Mitte, Humboldt University, Berlin, Germany; 3Department of General-, Visceral- and Transplant-Surgery, Charité - Campus Virchow Klinikum, Humboldt University, Berlin, Germany

W768 REJECTION AFTER PANCREAS TRANSPLANTATION Jacques Malaise, Christoph Dieterle, Antonio Secchi, EUROSPK Study Group. EUROSPK, EUROSPK Central Office, Brussels, Belgium

W769 POST TRANSPLANT DIABETES MELLITUS – RISK FACTORS, INSULIN KINETICS AND EARLY MARKERS Manisha Sahay, Girish Narayen, Anuradha Raman. Department of Nephrology, Osmania General Hospital, Hyderabad, Andhra Pradesh, India

W770 POSTTRANSPLANT DIABETES MELLITUS (PTDM) IN RENAL TRANSPLANT RECIPIENTS: A SINGLE CENTER REPORT Sali Aswad, Moses Spira, Mohamed Amer, Mazen Sabawi, Robert Mendez. Transplantation, National Institute of Transplantation, Los Angeles, CA, United States

465 WEDNESDAY, JUNE 12 POSTERS

W771 RENAL TRANSPLANTATION RESTORES SYMPATHOVAGAL BALANCE AND NORMAL CIRCADIAN VARIATIONS OF HEART RATE IN PATIENTS WITH DIABETES MELLITUS Dvora Rubinger,1 Rebecca Backenroth,1 Myron H. Luria,2 Dan Sapoznikov.2 1Nephrology and Hypertension, Hadassah University Hospital, Jerusalem, Israel; 2Cardiology, Hadassah University Hospital, Jerusalem, Israel

W772 PRE-EMPTIVE LIVE-DONOR KIDNEY TRANSPLANTATION: CLINICAL COURSE AND OUTCOME Amgad El-Agroudy, Mohamed Adel Bakr, Ahmed Donia, Mohamed Ashraf Foda, Mohamed Ahmed Ghoneim. Nephrology, Urology & Nephrology Center, Mansoura, DK, Egypt

W773 OUR EXPERIENCE WITH PRE EMPTIVE KIDNEY TRANSPLANTATION Rajko Hrvacevic, Zoran Paunic, Neven Vavic, Ljiljana Ignjatovic, Zoran Kovacevic. Clinic of Nephrology, Military Medical Academy, Belgrade, Serbia, Yugoslavia

W774 IMPACT OF DONOR/RECIPIENT BODY WEIGHT MISMATCH ON PATIENT AND GRAFT OUTCOME IN LIVING-DONOR KIDNEY TRANSPLANTATION Amgad El-Agroudy, Ahmed Shokeir, Mohamed Ahmed Ghoneim. Nephrology, Urology & Nephrology Center, Mansoura, DK, Egypt

W775 ELISPOT ANALYSIS OF DONOR-SPECIFIC EFFECTOR T CELL FREQUENCIES PRE- AND POST RENAL TRANSPLANTATION - CORRELATION WITH 6 MONTHS GRAFT FUNCTION AND REJECTION Peter Nickel,1 Franziska Presber,2 Gantuja Bold,1 Didier Bitti,1 Gottfried May,3 Schoenemann Constanze,4 Hans-Dieter Volk,2 Petra Reinke.1 1Department of Nephrology and Intensive Care, Charité Medical School Humboldt University, Berlin, Germany; 2Institute for Medical Immunology, Charité Medical School Humboldt University, Berlin, Germany; 3Department of Surgery, Charité Medical School Humboldt University, Berlin, Germany; 4HLA Laboratory, Institute of Transfusion Medicine, Charité Medical School Humboldt University, Berlin, Germany

W776 REJECTION RATE AND OUTCOME IN YOUNG AND OLD RECIPIENTS OF OLD KIDNEY TRANSPLANT DONORS Christine Koch,1 Christian Forster,1 Patrick Wiese,1 Brigitte Roth,1 Regine Riess,2 Barbara Nonnast-Daniel.1 1University of Erlangen, Nephrology, 4. Med. Clinic, Nuernberg, Germany; 2Hospital of Nuernberg, Pathology, Nuernberg, Germany

W777 USE OF EN BLOC SMALL PEDIATRIC KIDNEYS IN ADULT RENAL TRANSPLANT RECIPIENTS: A FIFTEEN YEAR EXPERIENCE Frederick K. Merkel.1,2,3 1General Surgery, Section of Transplantation, Rush-Presbyterian-St. Luke’s Hospital, Chicago, IL, United States; 2Surgery, The University of Illinois (UIC) Hospital, Chicago, IL, United States; 3The Chicago Regional Organ and Tissue Bank, Chicago, IL, United States

W778 SHORT TERM COMPLICATIONS IN LIVE KIDNEY DONORS. PROSPECTIVE DATA FROM 500 CONSEQUTIVE CASES FROM A SINGLE CENTRE Lars Westlie, Kathe Meyer, Bjoern Lien, Hallvard Holdaas, Anders Hartmann, Per Fauchald. Section of Nephrology, Medical and Surgical Department, National Hospital, Oslo, Norway

466 POSTERS WEDNESDAY, JUNE 12

W779 OLDER DONOR AGE IS ASSOCIATED WITH EXCELLENT GRAFT OUTCOMES IN LIVING DONOR KIDNEY TRANSPLANTATION Lourdes Pena de la Vega,1 Alvaro Torres,1 Humberto Bohorquez,2 James M. Gloor,1 Thomas R. Schwab,1 Jorge A. Velosa,1 Timothy S. WEDNESDAY Larson,1 Mark D. Stegall,2 Stephen C. Textor,1 Matthew D. Griffin.1 1Dept. Internal Medicine, Division of Nephrology, Mayo Clinic and Foundation, Rochester, MN, United States; 2Dept. Surgery, Division of Transplantation Surgery, Mayo Clinic and Foundation, Rochester, MN, United States

W780 INCIDENCE & RISK FACTORS OF DELAYED GRAFT FUNCTION & ITS IMPACT ON LONG-TERM GRAFT SURVIVAL IN LIVING KIDNEY TRANSPLANT Ghanbar Ali Raiss Jalali, R. Arsalanizadeh, S.A. Malek Hosseini, J. Roozbeh, S. Behzadi. Transplant, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

W781 AMONG THERAPY MODALITIES OF END STAGE RENAL DISEASE; RENAL TRANSPLANTATION IMPROVES SURVIVAL IN PATIENTS WITH AMILOIDOSIS B. Handan Ozdemir,1 F. Nurhan Ozdemir,2 Siren Sezer,2 Zubeyde Arat,2 Mehmet Haberal.3 1Pathology, Baskent University Faculty of Medicine, Ankara, Turkey; 2Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey; 3General Surgery, Baskent University Faculty of Medicine, Ankara, Turkey

W782 USING CLINICAL RISK EVALUATION TABLES TO ESTIMATE THE OUTCOME OF PATIENTS BEING EVALUATED FOR A KIDNEY TRANSPLANT Sarbjit V. Jassal,1 Douglas E. Schaubel,2 Stanley S.A. Fenton.1 1Medicine, University Health Network, Toronto, ON, Canada; 2Biostatistics, University of Michigan, Ann Arbor, MI, United States

W783 THE INFLUENCE OF END-STAGE RENAL DISEASE MODALITY OF TREATMENT (HAEMODIALYSIS, PERITONEAL DIALYSIS) ON THE ACCESS TO AND RESULTS OF RENAL TRANSPLANTATION Denis Glotz,1,2 Ylana Chalem,3 Jean-Philippe Ryckelynck,4 Christian Verger,5 Philippe Tuppin.3 1Nephrology, Hopital Georges Pompidou, Paris, France; 2INSERM U430, Paris, France; 3Evaluation Medicale, Etablissement Francais des Greffes, Paris, France; 4Nephrology, C.H.U. de Caen, Caen, France; 5Nephrology, C.H. Rene Dubos, Pontoise, France

W784 THE ROLE OF TRANSPLANT RECIPIENT CHARACTERISTICS ON GRAFT SURVIVAL FOR “MARGINAL” VERSUS STANDARD DONOR ORGANS Robert Wolfe,1 Mary Guidinger,2 Jennifer Bragg-Gresham,2 Robert Merion,3 Francis Delmonico,4 Eric Young,5 James Wynn,6 Philip Held,2 Friedrich Port.2 1Biostatistics/KECC, Univ. of Michigan, Ann Arbor, MI, United States; 2DOPPS, URREA, Ann Arbor, MI, United States; 3Dept. of Surgery, Univ. of Michigan, Ann Arbor, MI, United States; 4Dept. of Surgery, Mass. General Hospital, Boston, MA, United States; 5Nephrology, VAMC/Univ. of Michigan, Ann Arbor, MI, United States; 6Dept. of Surgery, Medical Coll. of Georgia, Augusta, GA, United States

W785 GLOMERULAR CRESCENTS IN IGA NEPHROPATHY DEVELOPING AFTER RENAL TRANSPLANTATION Hyeon Joo Jeong,1 Ki Whan Kwon,2 Yu Seun Kim,2 Soon Il Kim,2 Dae Suk Han,3 Ho Yung Lee,3 Kiil Park.2 1Pathology, Yonsei University College of Medicine, Seoul, Korea; 2Surgery, Yonsei University College of Medicine, Seoul, Korea; 3Internal Medicine, Yonsei University College of Medicine, Seoul, Korea

467 WEDNESDAY, JUNE 12 POSTERS

W786 GENETIC FACTORS AND IgA NEHROPATHY RECURRENCE Federica Lombardo,1 Monica Chiesa,1 Patrizia Passerini,2 Alessandro Amore,1 Paola Cirina,1 Giovanni Conti,1 Antonio Tarantino,2 Roberta Giraudi,3 Maria Messina,3 Giuseppe Segoloni,3 Claudio Ponticelli,2 Rosanna Coppo.1 1Nephrology Dialysis Transplantation, Regina Margherita Children’s Hospital, Torino, Italy; 2Nephrology Dialysis Transplantation, S Giovanni Battista Hospital, Torino, Italy; 3Nephrology Dialysis Transplantation, Policlinico, Milano, Italy

W787 RISK FACTORS FOR PRIMARY IGA NEPHROPATHY (IgAN) RECURRENCE AFTER RENAL TRANSPLANTATION (RTx) François Berthoux, Eric Diconne, Christophe Mariat, Damien Thibaudin, Eric Alamartine, Jean Pierre De Filippis, Blandine Laurent, Abdelaziz Ziane, Aida Afiani. NDT Department, University North Hospital, Saint-Etienne, France

W788 EFFECT OF KIDNEY TRANSPLPANTATION ON ACQUIRED CYSTS IN NATIVE KIDNEYS Ghanbar Ali Raiss Jalali, M. Araste, B. Nematee Honar, S.A. Malek Hosseini. Transplant, Shiraz University of Medical Sciences, Shiraz, Fars, Iran;

W789 HIGH PRE-TRANSPLANT SERUM LEVELS OF IP-10 PREDICT EARLY RENAL ALLOGRAFT FAILURE Elisabetta Bertoni,1 Paola Romagnani,2 Mario Rotondi,2 Alberto Rosati,1 Andrea Buonamano,2 Laura Lasagni,2 Elena Lazzeri,3 Fabio Pradella,1 Vittorio Fossombroni,1 Mario Serio,2 Maurizio Salvadori.1 1Dept of Renal Transplantation, Careggi University Hospital, Florence, Italy; 2Dept of Clinical Physiopathology, University of Florence, Florence, Italy; 3Dept of Internal Medicine, University of Florence, Florence, Italy

468 POSTERS WEDNESDAY, JUNE 12

TRANSPLANTATION: MISCELLANEOUS

W790 TUBERCULOUS OSTEOMYELITIS OF CLAVICLE AND MAXILLA WEDNESDAY IN TWO RENAL TRANSPLANT RECIPIENTS Kunal Chaudhary, K.S. Nayak. Nephrology, Global Hospitals, Hyderabad, A.P., India

W791 LONG-TERM OUTCOME OF ISONIAZID PROPHYLAXIS FOR TUBERCULOSIS IN CHINESE RENAL TRANSPLANT RECIPIENTS Sing Leung Lui, Fu Keung Li, Bo Ying Choy, Tak Mao Chan, Wai Kei Lo, Kar Neng Lai. Medicine, Queen Mary Hospital, Hong Kong SAR, China

W792 PREVALENCE OF TUBERCULOSIS AFTER RENAL TRANSPLANTATION Pedram Ahmadpour,1 Mahboob Lessan Pezeshki,1 Mohammad Reza Khatami,1 Behzad Einolahi,2 Khadijeh Makhdoomi,3 Effat Razeghi,1 Mitra Mahdavi Mazdeh,1 Sepideh Seyfi.1 1Nephrology, Tehran University of Medical Science, Tehran, Iran; 2Nephrology, Baghiatollah Medical Center, Tehran; 3Nephrology, Urmia Medical School, Urmia, Iran

W793 THE ADVERSE IMPACT OF PRETRANSPLANT BK VIRUS INFECTION ON RENAL ALLOGRAFT FUNCTION Vivekanand Jha,1 Ashik Hayat,1 Srinivasan Radhika,2 Man Updesh Singh Sachdeva,3 Ritambra Nada,3 Harbir Kohli,1 Kamal Sud,1 Krishan Gupta,1 Kusum Joshi,3 Vinay Sakhuja.1 1Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; 2Cytology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; 3Histopathology, Postgraduate Institute of Medical Education and Research,Chandigarh, India

W794 CMV INFECTIONS IN PRIMARY SIMULTANEOUS PANCREAS- KIDNEY (SPK) TRANSPLANTATION: RESULTS AT 1 YEAR OF A LARGE MULTICENTER TRIAL Jacques Malaise, Dirk Kuypers, Helmut Arbogast, EUROSPK Study Group. EUROSPK Central Office, EUROSPK Central Office, Brussels, Belgium

W795 LATE CMV DISEASE AND/OR RECURRENCE IN RENAL TRANSPLANTS WITH PROLONGED PROPHYLAXIS WITH ORAL GANCICLOVIR (CMV) E. Gómez, A.S. Laurés, S. Melón, J.M. Baltar, M. de Oña. 1Nephrology, Hospital Central de Asturias, Oviedo, Asturias, Spain; 2Microbiology, Hospital Central de Asturias, Oviedo, Asturias, Spain

W796 PRE-EMPTIVE THERAPY IS EFFECTIVE IN THE PREVENTION OF CMV DISEASE FOLLOWING RENAL TRANSPLANTATION Ali Bakran,1 S. Sunil,1 Sanjay Sinha,1 Luis Cuevas,2 William Tong.3 1Transplant Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom; 2Statistical Department, Tropical School of Medicine, Liverpool, United Kingdom; 3Department of Infection, Guy’s and St. Thomas’ Hospital, London, United Kingdom

W797 CYTOMEGALOVIRUS PROPHYLAXIS WITH GANCICLOVIR IN KIDNEY TRANSPLANT RECIPIENTS RECEIVING ANTI- LYMPHOCYTE ANTIBODY INDUCTION IMMUNOSUPPRESSION T. Said,1 M.R.N. Nampoory,1 K.V. Johny,2 A.S. Pacsa,3 M.P. Nair,1 M. Abdel-Haleem,1 M. Samhan,1 M. Al-Mousawi.1 1Hamed Al-Essa Organ Transplant Center, Ibn Sina Hospital, Kuwait; 2Department of Medicine, 3Department of Microbiology, Faculty of Medicine, Kuwait

469 WEDNESDAY, JUNE 12 POSTERS

W798 SEQUENTIAL CYTOMEGALOVIRUS ANTIGENEMIA MONITORING IN HIGH RISK KIDNEY TRANSPLANT PATIENTS Kikumi Suzete Ozaki,1,2 Jose Osmar Medina Pestana,1,2 Alvaro Pacheco e Silva Filho,1,2 Luis Fernando Aranha Camargo.2 1Nephrology Div., Univ. Federal de Sao Paulo, Sao Paulo, SP, Brazil; 2Infections Disease, Fundacao Oswaldo Ramos, Sao Paulo, SP, Brazil

W799 INFLUENCE OF CD3 MONITORIZATION OF ANTI-THYMOCYTE GLOBULIN TREATMENT ON CMV INFECTION IN RENAL TRANSPLANT RECIPIENTS Murat Tuncer,1 Dilek Colak,2 Alihan Gurkan,3 Asuman Yavuz,1 Caglar Ruhi,1 Serdar Kacar,3 Alper Demirbas,3 Mustafa Akaydin,3 Fevzi Ersoy,1 Gulsen Yakupoglu.1 1Medicine, Akdeniz Univ., Antalya, Turkey; 2Microbiology, Akdeniz Univ., Antalya, Turkey; 3General Surgery, Akdeniz Univ., Antalya, Turkey

W800 OUTCOME OF HBsAg POSITIVE RENAL TRANSPLANT RECIPIENTS AND THEIR RESPONSE TO LAMIVUDINE THERAPY- INDIAN SCENARIO Prem P. Varma, S.R. Gedela, Durga Shankar, A.C. Anand. 1Nephrology, Army Hospital (R&R), Delhi Cantt, Delhi, India; 2Gastroenterology, Army Hospital (R&R), Delhi Cantt, Delhi, India

W801 PREVALENCE OF HHV-8 INFECTION AMONG HEALTHY CONTROLS AND IMMUNOCOMPROMISED INDIVIDUALS Brigitta Lönard,1 Martina Sester,1 Urban Sester,1 Hans Pees,2 Barbara Gärtner,3 Hans Köhler.1 1Medical Dept IV, University of the Saarland, Homburg, Germany; 2Medical Dept I, University of the Saarland, Homburg, Germany; 3Dept of Virology, University of the Saarland, Homburg, Germany

W802 JCV AND BKV DNA MONITORING BY DUPLEX NESTED-PCR IN URINE AND SERUM SAMPLES FROM RENAL TRANSPLANT RECIPIENTS Chiara Merlino,1 Franca Giacchino,2 Massimiliano Bergallo,1 Paola Belardi,2 Giuseppe P. Segoloni,3 Rossana Cavallo.1 1Dept Public Health and Microbiology - Virology Unit, Univ of Turin, Turin, Italy; 2Dept Nephro-Urology - Nephrology and Dialysis Unit, Civil Hospital, Ivrea, Turin, Italy; 3Dept Internal Medicine - Renal Transplant Unit, Univ of Turin, Turin, Italy

W803 POLYOMAVIRUS INFECTION AND REACTIVATION IN RENAL TRANSPLANT PATIENTS Federica Capurro,1 Maddalena Brustia,1 Elisabetta Omodeo Zorini,2 Maria Cristina Barbè,1 Cristina Cornella,1 Ernesto Turello,1 Renzo Boldorini,2 Guido Monga,2 Giuseppe Verzetti.1 1Division of Nephrology, Dialysis and Transplantation, Maggiore della Carità Hospital, Novara, Italy; 2Chair of Pathology, Piemonte Orientale Amedeo Avogadro Medical University, Novara, Italy

W804 DIAGNOSIS OF POLYOMA VIRUS NEPHRITIS IN A RENAL TRANSPLANT ARGENTINIAN POPULATION Julio Goldberg,1,2,3 Ziomara Balbarrey.1,2 1Pathology, Instituto de Nefrología de Buenos Aires, Buenos Aires, Argentina; 2Pathology, Hospital Garrahan, Buenos Aires, Argentina; 3Pathology, Argerich, Buenos Aires, Argentina

W805 REAL-TIME RT-PCR ANALYSIS FOR POLYOMAVIRUS DNA AND RNA IN RENAL ALLOGRAFT BIOPSIES AS A SCREENING TOOL FOR BK VIRUS TRANSPLANT NEPHROPATHY Holger Schmid,1 Hans Nitschko,2 Karin Frach,1 Herrmann J. Groene,3 Detlef Schloendorff,1 Matthias Kretzler.1 1Nephrological Center, Medical Policlinic, Ludwig-Maximilians- Univ., Munich, Germany; 2Max von Pettenkofer Institut, Ludwig- Maximilians-Univ., Munich, Germany; 3Dept of Molecular and Cellular Pathology, German Cancer Research Center, Heidelberg, Germany

470 POSTERS WEDNESDAY, JUNE 12

PAEDIATRIC NEPHROLOGY PAEDIATRIC NEPHROLOGY PHYSIOLOGY WEDNESDAY

W806 CYSTATIN C IS A PROMISING MARKER OF RENAL FUNCTION IN NEWBORNS DURING THE FIRST 3 MONTHS H. Kulkarni, K. Jureidini, P. Trnka, P. Henning, R. Vigneswaran (late), S. Harris. Pediatric Nephrology and Neonatology, Women’s and Children’s Hospital, Adelaide, South Australia, Australia

W807 DOSE-DEPENDENT SIDE EFFECTS OF NIMESULIDE ON THE IMMATURE KIDNEY Anne Prevot, Dolores Mosig, Jean-Pierre Guignard. Department of Pediatrics, Renal Unit, CHUV, Lausanne, Switzerland

W808 RENAL GROWTH AND BODY COMPOSITION IN CHILDREN: CORRELATION BETWEEN SONOGRAPHY AND BIOIMPEDANCE ANALYSIS (BIA) Claudio Cristofano,1 Luigi Vernaglione,1 Franco Perrone,1 Elena Corridori,2 Stefano Chimienti.1 1Nephrology and Dialysis Unit, “M. Giannuzzi” - Hospital, Manduria, Taranto, Italy; 2Pediatrician, ASL TA/1, S. Marzano, Taranto, Italy

W809 EFFECT OF PHOTOTHERAPY ON URINARY CALCIUM TO CREATININ RATIO IN NEONATES Nakisa Hooman,1 Ali Honarpisheh,2 Ziba Mosayebi.2 1Nephrology, Ali - Asgar Children Hospital, Tehran, Iran; 2Neonatology, Beheshti Hospital, Kashan, Iran

W810 SIMPLE ESTIMATION OF GLOMERULAR FILTRATION RATE APPROPRIATE IN SICK THAI CHILDREN Prayong Vachvanichsanong,1 Pirun Saeteu,1 Alan Geater.2 1Department of Pediatrics,Faculty of Medicine, Prince of Songkla University, Hat-Yai, Thailand; 2Epidemiology Unit,Faculty of Medicine, Prince of Songkla University, Hat-Yai, Thailand

W811 QUANTITATION OF PROTEINURIA WITH URINARY PROTEIN TO OSMOLALITY RATIO IN CHILDREN Nakisa Hooman,1 Hasan Otukesh,1 Hamid Reza Safaii,1 Mitra Mehrazma,2 Shokrolah Yousefi.2 1Nephrology, Ali - Asgar Children Hospital, Tehran, Iran; 2Pathology, Ali - Asgar Children Hospital, Tehran, Iran

W812 FACTORS INFLUENCING VARIABILITY OF AMBULATORY 24 HR CREATININE CLEARANCE IN CHILDREN Michiel Schreuder, Ans van Wijk, Arend Bökenkamp. Pediatric Nephrology, VU University Medical Center, Amsterdam, Netherlands

W813 LACK OF SEASONAL VARIATIONS IN URINARY CALCIUM/ CREATININE RATIO IN SCHOOL AGE CHILDREN Michelle Stuart-Hilgenfeld,1 Stephen Simon,2 Douglas Blowey,1 Dave Cokely,2 Wendy Richmond,1 Uri S. Alon.1 1Section of Nephrology, Children’s Mercy Hospital, Kansas City, MO, United States; 2Department of Medical Research, Children’s Mercy Hospital, Kansas City, MO, United States

W814 AMBULATORY BLOOD PRESSURE VALUES IN HEALTHY CHILDREN Dusan Paripovic, Amira Peco-Antic. Nephrology, University Children’s Hospital, Belgrade, Serbia, Yugoslavia

471 WEDNESDAY, JUNE 12 POSTERS

PAEDIATRIC NEPHROLOGY PATHOLOGY

W815 AN IMMUNOHISTOCHEMICAL AND ELECTRON-MICROSCOPIC STUDY OF IMMATURE GLOMERULI IN CHILDREN WITH NE- PHROTIC SYNDROME GLOMERULOPATHIES (IN RELATION WITH CLINICAL FINDINGS) Aldona Wozniak,1 Wieslawa Salwa-Zurawska,1 Jakub Zurawski,1 Danuta Ostalska-Nowicka.2 1Department of Clinical Pathomorphology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland; 2Department of Pediatric Nephrology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland

W816 EXPRESSION OF ICAM-1 AND TGF β IN RENAL BIOPSIES IN CHILDREN WITH HYDRONEPHROSIS - CLINICOPATOLOGIC CORRELATION Tomas Tichy,1 Pavel Geier,2 Oldrich Smakal,3 Kamila Michalkova,4 Hana Floegelova.2 1Department of Patology, Palacky University, Olomouc, Czech Re- public; 2Department of Pediatrics, Teaching Hospital, Olomouc, Czech Republic; 3Department of Urology, Teaching Hospital, Olomouc, Czech Republic; 4Department of Radiology, Teaching Hospital, Olomouc, Czech Republic

W817 RENAL LOCALIZATION OF CYSTINOSIN Liliana Mannucci,1 Konstantinos Giannakakis,2 Andrea Onetti Muda,2 Gianfranco Rizzoni,1 Francesco Emma.1 1Division of Nephrology, Bambino Gesù Children’s Hospital and Research Institute, Rome, Italy; 2Department of Experimental Medi- cine & Pathology, La Sapienza University, Rome, Italy

472 POSTERS WEDNESDAY, JUNE 12

PAEDIATRIC NEPHROLOGY PATHOLOGY WEDNESDAY

W818 THE ANGIOTENSIN II ANTAGONIST IRBESARTAN IS SUPERIOR TO THE DIHYDROPYRIDINE CALCIUM-CHANNEL BLOCKER AMLODIPINE IN CHILDHOOD CHRONIC KIDNEY DISEASE WITH OVERT PROTEINURIA Mario G. Bianchetti,1,2 Alberto Edefonti,1 Emilio Fossali, Rodo O. von Vigier.2 1Pediatric Renal Unit, Clinica De Marchi, Milan, Italy; 2Division of Nephrology, Kinderklinik, Berne, Switzerland

W819 LISINOPRIL: PHARMACOKINETIC AND PHARMACODYNAMIC CHARACTERISTICS Johan Vande Walle, Ann Raes, Fransiska Malfait, Sarah Van Aken, Annick France, Joke Dehoorne. Pediatric Nephrology, UZ Gent Pediatrics, Gent, Belgium

W820 SHOULD THE SCHWARTZ GFR ESTIMATE IN CHILDREN BE REPLACED WITH AN ESTIMATE DERIVED FROM CYSTATIN C? Guido Filler,1 Nathalie Lepage.2 1Pediatrics, Division of Nephrology, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada; 2Laboratory Medicine, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada

W821 NEPHROTOXICITY OF AMINOGLYCOSIDES IN YOUNG NEWBORNS Ranko Nikolic,1 Amira Peco-Antic.2 1Gynecology, Hospital for Gynecology and Obstetrics, Paracin, Serbia, Yugoslavia; 2Nephrology, University Children’s Hospital, Belgrade, Serbia, Yugoslavia

W822 MECHANISMS OF THE NEPHROTOXICITY OF IFOSFAMIDE AND ITS METABOLITES IN PROXIMAL TUBULAR CELLS: AN IN VITRO MODEL Michael Gekle,1 Brigitte Wollny,2 Nader Gordjani.2 1Physiologisches Institut, University of Würzburg, Würzburg, Germany; 2Universitäts-Kinderklinik, University of Würzburg, Würzburg, Germany

473 WEDNESDAY, JUNE 12 POSTERS

PAEDIATRIC CLINICAL NEPHROLOGY, ACUTE AND CHRONIC RENAL FAILURE, BONE AND MINERAL METABOLISM, ANAEMIA MISCELLANEOUS

W823 USEFULNESS OF RENAL RADIOLOGY AND SCINTIGRAPHY IN CHILDREN WITH A FIRST EPISODE OF UPPER URINARY TRACT INFECTION Giovanni Montini, Pietro Zucchetta, Daniela Gobber, Luisa Murer, Luca Rigon, Antonella Toffolo, Luigi Pavanello, Roberto Dall’Amico, Enrico Talenti, Paolo Molinari, Francesca Maschio, Walburga Cassar, Dante Scorrano, Andrea Zucchini, Sergio Zanchetta, Alessandro Calderan, Stefania Comacchio, Waifro Rigamonti, Graziella Zacchello, on Behalf of the IRIS Study Group. Coordinating Center:Department of Pediatrics, Nephrology, Dialysis and Transplant Unit, Padova, Italy

W824 THE EVALUATION OF URINE ENZYMES (LDH, SGOT, SGPT) IN DIFFERENTIATION OF UPPER AND LOWER URINARY TRACT INFECTION IN CHILDREN Hassan Outokesh, Saeed Sabaghi, Rozita Hosseini, Gholamreza Seraj. Pediatric Nephrology, Ali Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran

W825 SERUM AND URINE INTERLEUKIN-6 AND TRANSFORMING GROWTH FACTOR-BETA1 IN NEONATES AND YOUNG INFANTS WITH PYELONEPHRITIS Maria Bitsori,1 Emmanouil Galanakis,1 Helen Dimitriou,2 Christina Giannakopoulou,3 Maria Kalmanti.2 1Dept of Paediatrics, Univ. of Crete, Heraklion, Crete, Greece; 2Dept of Paediatric Haematology-Oncology, Univ. of Crete, Heraklion, Crete, Greece; 3Neonatal Intensive Care Unit, Univ. of Crete, Heraklion, Crete, Greece

W826 IDENTIFICATION OF VIRULENCE FACTORS OF E.COLI IN FIRST TIME ACUTE PYELONEPHRITIS (APN) IN CHILDREN Marie Françoise Prere,1 Christine Azema,2 Isabelle Eychenne,1 Marie Bourjot,2 Stéphane Decramer,2 François Bouissou.2 1Bactériologie, CHU Purpan, Toulouse, France; 2Néphrologie Pédiatrique, Hôpital des Enfants, Toulouse, France

W827 BACTERIURIA AND URINARY TRACT INFECTIONS IN MALNOURISHED CHILDREN Pankaj Hari, Partha Tripathi, Arvind Bagga. Pediatrics, All India Institute of Medical Sciences, New Delhi, India

W828 VIRULENCE GENES IN UROPATHOGENIC ESCHERICHIA COLI AND ITS EFFECT ON URINARY TRACT INFECTION Inseok Lim. Pediatric Nephrology, ChungAng University Hospital, Seoul, Korea

W829 URINARY TRACT PATHOGENS AND THEIR ANTIMICROBIAL RESISTANCE PATTERNS IN CHILDREN Ibrahim Gokce, Nese Karaaslan Biyikli, Harika Alpay. Pediatric Nephrology, Marmara University Faculty of Medicine, Istanbul, Turkey

W830 RESISTANCE OF BACTERIAL STRAINS CAUSING URINARY TRACT INFECTION IN CHILDREN Sverker Hansson,1 Ulf Jodal,1 Åke Svedhem.2 1Department of Pediatrics, The Queen Silvia Children’s Hospital, Göteborg, Sweden; 2Clinical Bacteriological Laboratory, Sahlgrenska University Hospital, Göteborg, Sweden

474 POSTERS WEDNESDAY, JUNE 12

W831 BACTERIAL PATHOGENS, RESISTANCE PATTERNS AND TREATMENT OPTIONS IN COMMUNITY ACQUIRED PAEDIATRIC URINARY TRACT INFECTION (UTI) Lars Pape,1 Gisela Offner,1 Jochen Ehrich,1 Florian Gunzer.2 WEDNESDAY 1Pediatric Nephrology, 2Microbiology, Medical School of Hannover, Hannover, Germany

W832 LONG-TERM CEFADROXIL PROPHYLAXIS IN CHILDREN WITH RECURRENT URINARY TRACT INFECTIONS Vytautas Baciulis,1 Grazina Eitutiene,2 Elvyra Baciuliene,1 Rimante Cerkauskiene,1 Augustina Jankauskiene.1 1Centre for Pediatrics, Vilnius University Children’s Hospital, Vilnius, Lithuania; 2Pediatric, Children’s Hospital of Klaipeda, Klaipeda, Lithuania

W833 ORAL vs INITIAL INTRAVENOUS ANTIBIOTIC TREATMENT OF URINARY TRACT INFECTIONS IN CHILDREN: A MULTICENTRE STUDY Giovanni Montini, Luisa Murer, Daniela Gobber, Stefania Comacchio, Antonella Toffolo, Roberto Dall’Amico, Paolo Molinari, Luigi Pavanello, Walburga Cassar, Francesca Maschio, Dante Scorrano, Andrea Zucchini, Sergio Zanchetta, Pietro Zucchetta, Alessandro Calderan, Luca Rigon, Graziella Zacchello, on Behalf of the IRIS Study Group. Coordinating Center: Nephrology, Dialysis and Transplant Unit, University of Padova, Padova, Italy

W834 OPTIMAL EVALUATION AND TREATMENT OF PAEDIATRIC “IDIOPATHIC” UROLITHIASIS Uri Alon, Michal Alon. Pediatric Nephrology, Children’s Mercy Hospital/University of Missouri at Kansas City, Kansas City, MO, United States

W835 METABOLIC ETIOLOGY IN PAEDIATRIC UROLITHIASIS Mustafa Bak, Rana Ural, Erkin Serdaroglu, Sebnem Calkavur, Hasan Agin. Division of Pediatric Nephrology, Dr.Behcet Uz Children Health and Disease Educational Hospital, Izmir, TR, Turkey

W836 “HAVE PLENTY OF FLUIDS” - DOES THE DICTUM WORK IN PAEDIATRIC UROLITHIASIS? Hannah Zimmerman, Michal Alon, Uri Alon. Pediatric Nephrology, Children’s Mercy Hospital/University of Missouri at Kansas City, Kansas City, MO, United States

W837 ASSOCIATION OF THE TISSUE KALLIKREIN AND TRANSFORMING GROWTH FACTOR-β1 GENE PROMOTER WITH RENAL PROGRESSION IN CHILDREN WITH VESICOURETERAL REFLUX Ching-Yuang Lin. Dept. of Pediatrics, Children Hospital, Changhua Christian Hospital, Changhua, Taiwan

W838 ACE GENE POYMORPHISM AND VESICOURETERIC REFLUX OF INFANTILE ONSET Seza Ozen,1 Mehmet Alikasifoglu,2 Sadettin Eskicorapci,3 Serdar Tekgul,3 Nesrin Besbas,1 Rezan Topaloglu,1 Ergul Tuncbilek,2 Aysin Bakkaloglu.1 1Pediatric Nephrology and Rheumatology, Hacettepe University, Ankara, Turkey; 2Genetics, Hacettepe University, Ankara, Turkey; 3Urology, Hacettepe University, Ankara, Turkey

475 WEDNESDAY, JUNE 12 POSTERS

W839 AMBULATORY BLOOD PRESSURE MONITORING (ABPM) IN CHILDREN WITH VESICO-URETERIC REFLUX (VUR) ASSOCIATED PERMANENT RENAL DAMAGE Joao Barreira,1 Susana Lira,1 Fernando Araujo,2 Manuel Pestana,3 Helena Jardim.4 1Pediatric Nephrology Unit, Hospital de S. Joao, Porto, Portugal; 2Lab.of Molecular Biology and Immuno-Haemotherapy Unit, Hospital de S.Joao, Porto, Portugal; 3Nephrology and Faculty of Medicine, Hospital de S. Joao, Porto, Portugal; 4Pediatric Nephrology

W840 G PROTEIN b3 SUBUNIT GENE C825T POLYMORPHISM IN PATIENTS WITH VESICO-URETERIC REFLUX Bostjan Zagradisnik,1 Natasa Marcun Varda,2 Nadja Kokalj Vokac,1 Katarina Bracic,2 Alojz Gregoric.2 1Laboratory of Medical Genetics, Maribor Teaching Hospital, Maribor, Slovenia; 2Department of Paediatrics, Maribor Teaching Hospital, Maribor, Slovenia

W841 CONSERVATIVE TREATMENT OF MODERATE-SEVERE PRIMARY VESICO-URETERIC REFLUX IN NEWBORN OUR EXPERIENCE Adela Urisarri, Hugo Villar, Alfredo Rguez-do Forno, Jose Luis Fdez- Iglesias, Marta Gil, Agustin Romay, Isabel Castro, Jose Rguez-Cervilla, Gema Ariceta. Nefrologia Pediatrica, Hospital Clinico Universitario, Santiago de Compostela, Spain

W842 VESICOURETERIC REFLUX AND CHRONIC RENAL FAILURE IN CHILDREN: PREDICTIVE FACTORS OF PROGRESSIVE DECLINE OF RENAL FUNCTION. DATA FROM THE ITALKID PROJECT Luigi Avolio,1 Gianluigi Ardissino,2 Sara Testa,3 Valeria Daccò,3 Sara Viganò,2 Aldo Claris-Appiani.3 1Division of Pediatric Surgery, IRCCS Policlinico S. Matteo, Pavia, Italy; 2Unit of Pediatric Nephrology, Dialysis and Transplantation - Dept. of Pediatrics, University of Milan, Milano, Italy; 3Department of Pediatrics, University of Milan, Milano, Italy

W843 RISK FACTORS OF DEVELOPMENT OF REFLUX-NEPHROPATHY IN CHILDREN Nagima Mustapayeva, Assiya Naushabayeva, Saule Dikanbaeva, Bakhyt Mailybaev, Saule Utelbayeva. Department of Urology, Scientific Center of Pediatrics and Children’s Surgery, Almaty, Kazakhstan

W844 REFLUX NEPHROPATHY: EARLY SIGNS OF SCARRING Fiodor Rusnak, Natalia Zaicova. Paediatric, Medical University, Chishinau, Republic of Moldova

W845 ARTERIAL HYPERTENSION IN CHILDREN WITH REFLUX NEPHROPATHY: FREQUENCY AND FACTORS PREDISPOSING TO ITS DEVELOPMENT Marina Aksenova,1 Tatiana Lepaeva,1 Vladimir Dlin,1 Dmitrij Fomin,2 Natalia Nazarova,3 Maya Ignatova.1 1Nephrology Department, Institute of Paediatrics and Children Surgery, Moscow, Russian Federation; 2Nuclear Department, Russian State Medical Univesity, Moscow, Russian Federation; 3Radiology Department, Institute of Paediatrics and Children Surgery, Moscow, Russian Federation

W846 CYSTOSONOGRAPHY WITH ECHOCONTRAST IN THE DIAGNOSIS OF VESICOURETERAL REFLUX IN CHILDREN Iwona Ogarek, Krystyna Sancewicz-Pach, Anna Pogan. Department of Pediatric Nephrology, Polish-American Children’s Hospital, Cracow, Poland

476 POSTERS WEDNESDAY, JUNE 12

PAEDIATRIC CLINICAL NEPHROLOGY, ACUTE AND CHRONIC RENAL FAILURE, BONE AND MINERAL METABOLISM, ANAEMIA WEDNESDAY ACUTE RENAL FAILURE

W847 CURRENT TREATMENT MODALITIES AND OUTCOMES IN CHILDREN WITH ACUTE RENAL FAILURE Ihab Sakr Shaheen,1 Alan R. Watson,1 Ben Harvey,1 Wendy Greenhalgh.2 1Children & Young People’s Kidney Unit, Nottingham City Hospital NHS Trust, Nottingham, United Kingdom; 2Clinical Effectiveness Department, Nottingham City Hospital NHS Trust, Nottingham, United Kingdom

W848 THE ASSOCIATION OF HSP-72 GENE POLYMORPHISM WITH ACUTE RENAL FAILURE IN VERY LOW-BIRTH WEIGHT INFANTS Andrea Fekete, Andras Treszl, Tivadar Tulassay, Barna Vasarhelyi. Research Laboratory of Paediatrics and Nephrology of I.Dept. of Paediatrics and Academy of Science, Semmelweis University, Budapest, Hungary

W849 PRESENCE OF TNF-α, IL-1 β, IL-6 AND IL-10 POLYMORPHISM AND THE RISK OF NEONATAL ACUTE RENAL FAILURE Peter Toth-Heyn, Andras Treszl, Peter Toth, Tivadar Tulassay, Barna Vasarhelyi. Joint Research Program of the First Department of Pediatrics, Semmelweis University and the Hungarian Academy of Sciences, Budapest, Hungary

W850 ACUTE RENAL FAILURE IN THE NEONATAL PERIOD Pinar Isik Agras,1 Esra Baskin,1 Nurcan Cengiz,1 Aylin Tarcan,2 Berkan Gurakan,2 Umit Saatci.1 1Pediatric Nephrology, Baskent University, Ankara, Turkey; 2Neonatology, Baskent University, Ankara, Turkey

477 WEDNESDAY, JUNE 12 POSTERS

PAEDIATRIC DIALYSIS PERITONEAL DIALYSIS

W851 ANTIFIBROTIC EFFECT OF INTRAPERITONEAL ANTI- THROMBIN III ON THE PERITONEAL MEMBRANE Sema Akman,1 Tekinalp Gelen,2 Mesut Coskun,4 Sibel Gokay,3 Elif Bahat,1 Ayfer Gur Guven.1 1Pediatric Nephrology, 2Pathology, 3Microbiology, 4Research Laboratory, Akdeniz University, Antalya, Turkey

W852 NEW METHODS OF OPERATIVE TREATMENT OF REFRACTORY EXIT SITE/TUNNEL INFECTION IN CHILDREN ON PERITONEAL DIALYSIS Stanislaw Warchol,1 Maria Roszkowska-Blaim,2 Beata Leszczynska,2 Teresa Dudek-Warchol.1 1Department of Cardiac Surgery and General Pediatric Surgery, Medical University of Warsaw, Warsaw, Poland; 2Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland

W853 EVALUATION OF HEARING STATUS IN PATIENTS WITH CHRONIC RENAL FALIURE TREATED WITH DIALYSIS Ewa Stefaniak,1 Joanna Zabel-Olejnik,2 Alfred Warzywoda,1 Waldemar Wojnowski,2 Jacek Zachwieja,1 Michal Grzegorowski.2 1Department of Pediatric Nephrology, University of Medical Sciences, Poznan, Poland; 2Department of Pediatric Otolaryngology, University of Medical Sciences, PoznañPhilippines

W854 P.D. CATHETER INSERTION IN INFANTS A NOVEL METHOD Shakunthala,1 Visweswar Reddy Pachipala,2 Girish Narayen,2 Anuradha.2 1Paediatrics, Niloufer Hospital, Hyderabad, Andhra Pradesh, India; 2Nephrology, Osmania General Hospital, Hyderabad, Andhra Pradesh, India

W855 THE ROLE OF LEPTIN AND SOLUBLE LEPTIN RECEPTOR ON THE NUTRITIONAL PARAMETERS IN PAEDIATRIC CPD PATIENTS Suleyman Kalman,1 Necla Buyan,1 Aysun Karabay Bayazit,2 Aysun Bideci,3 Sevcan Bakkaloglu,1 Ozan Ozkaya,1 Oguz Soylemezoglu.1 1Pediatric Nephrology, Gazi University Medical Faculty, Ankara, Turkey; 2Pediatric Nephrology, Cukurova University Medical Faculty, Adana, Turkey; 3Pediatric Endocrinology, Gazi University Medical Faculty, Ankara, Turkey

W856 INFECTIOUS COMPLICATIONS IN YOUNG CHILDREN ON PERITONEAL DIALYSIS: TENCKHOFF VERSUS PRESTERNAL PERITONEAL CATHETER Stanislaw Warchol,1 Maria Roszkowska-Blaim,2 Helena Ziolkowska,2 Beata Leszczynska,2 Teresa Dudek-Warchol.1 1Department of Cardiac Surgery and General Pediatric Surgery, Medical University of Warsaw, Warsaw, Poland; 2Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland

W857 THE CLINICAL VALUE OF ULTRASONOGRAPHY IN THE FOLLOW-UP OF PAEDIATRIC PERITONEAL DIALYSIS PATIENTS Aydan Sirin, Sasan Radjazi, Ilmay Bilge, Sevinc Emre, Banu Sadikoglu, Alev Yavuz Yilmaz. Pediatric Nephrology, University of Istanbul, Istanbul Medical Faculty, Istanbul, Turkey

W858 PERITONITIS IN CHILDREN ON PERITONEAL DIALYSIS - ONE CENTER EXPERIENCE N. Yildiz, H. Alpay, M. Erten, M. Erguven. Dept of Pediatric Nephrology, SSK Goztepe Education Hosp., Turkey

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W859 PERITONITIS IN 205 CHILDREN ON CHRONIC PERITONEAL DIALYSIS. A 3-YEAR NATIONAL SURVEY (2000-2002) Aleksandra Zurowska,1 Joanna Latoszynska,8 Maria Szczepanska,9 Helena Ziolkowska,2 Ewa Stefaniak,3 Irena Makulska,4 Anna WEDNESDAY Jander,10 Dorota Drozdz,5 Ryszard Wiercinski,6 Barbara Kolataj,7 Barbara Socik,11 Hanna Kipigroch.12 1Paediatric Nephrology, University Medical School, Gdansk; 2Warsaw; 3Poznan; 4Wroclaw; 5Krakow; 6Bialystok; 7Lublin; 8Childrens Hospital, Warsaw; 9Zabrze; 10Lodz; 11Szczecin; 12Torun, Poland

W860 A MULTICENTER STUDY ON THE PREVALENCE OF MALNUTRITION ASSESSED BY THE ANTHROPOMETRY-BIA NUTRITIONAL SCORE (ABN SCORE) IN CHILDREN ON CHRONIC PERITONEAL DIALYSIS (CPD) Alberto Edefonti,1 Marina Picca,1 Fabio Paglialonga,1 Silvana Loi,1 Maria Rosa Grassi,1 Gianluigi Ardissino,1 Graziella Zacchello,2 Giancarlo Lavoratti,3 Enrico Verrina,4 Stefano Rinaldi,5 Antonio Ciofani,6 Palma Sorino.7 1Nephrology and Dialysis Unit, Clinica Pediatrica De Marchi, Milano, Italy; 2Pediatric Nephrology Unit, Clinica Pediatrica, Padova, Italy; 3Pediatric Nephrology Unit, Ospedale Meyer, Firenze, Italy; 4Pediatric Nephrology Unit, Istituto G. Gaslini, Genova,

W861 RELATIVE PREVALENCE OF GRAM NEGATIVE PERITONITIS IN CHILDREN ON AUTOMATED PERITONEAL DIALYSIS AND ST.AUREUS PROPHYLAXIS Aleksandra Zurowska, Ilona Zagozdzon, Irena Balasz, Iga Lesniewska, Dagmara Borzych, Ewa Marczak. Paediatric Nephrology, University Medical School, Gdansk, Poland

W862 ICODEXTRIN SOLUTION IN ANURIC CHILDREN TREATED WITH AUTOMATED PERITONEAL DIALYSIS Irena Balasz, Aleksandra Zurowska, Ilona Zagozdzon, Iga Lesniewska, Ewa Marczak. Paediatric Nephrology, University Medical School, Gdansk, Poland

W863 A RETROSPECTIVE STUDY OF ICODEXTRIN USE IN PAEDIATRIC PERITONEAL DIALYSIS PATIENTS Vladimirs Strazdins, Ilze Andersone, Ineta Sosare. Nephrology, University Hospital for Children, Riga, Latvia

W864 DIALYSIS TREATMENT OF PAEDIATRIC PATIENTS INFECTED WITH THE HUMAN IMMUNODEFICIENCY VIRUS (HIV) Gaston Zilleruelo, Carolyn Abitbol, Hans Hubsch, Brenda Montane, Jayanthi Chandar, Jose Strauss. Pediatrics, University of Miami/Holtz Children’s Hospital, Miami, FL, United States

W865 A 7 YEAR SURVEY OF PERITONITIS IN A PAEDIATRIC AUTOMATED PERITONEAL DIALYSIS (APD) PROGRAMME Mohamed Abdelraheem, Alan R. Watson. Children & Young People’s Kidney Unit, Nottingham City Hospital NHS Trust, Nottingham, United Kingdom

W866 A TWELVE-YEAR MULTICENTER EXPERIENCE ON PATIENT AND TECHNIQUE SURVIVAL IN PAEDIATRIC PATIENTS ON CHRONIC PERITONEAL DIALYSIS AND HEMODIALYSIS Enrico Verrina, Alberto Edefonti, Bruno Gianoglio, Stefano Rinaldi, Palma Sorino, Graziella Zacchello, Giancarlo Lavoratti, Silvio Maringhini, Carmine Pecoraro, Maria Grazia Calevo, Laura Turrini Dertenois, Francesco Perfumo. Italian Registry of Pediatric Chronic Dialysis, G. Gaslini Children’s Hospital, Genoa, Italy

479 WEDNESDAY, JUNE 12 POSTERS

PAEDIATRIC TRANSPLANTATION INFECTIONS

W867 OUTBREAK OF PNEUMOCYSTIS JIROVECI (PCP) PNEUMONIA IN A PAEDIATRIC RENAL TRANSPLANT UNIT Britta Hoecker,1 Lutz Weber,1 Johannes Poeschl,1 Eugen Zilow,1 Constanze Wendt,2 Heiko Geiss,2 Franz-Michael Mueller,1 Otto Mehls,1 Burkhard Toenshoff.1 1Department of Pediatrics, Univ. Children’s Hospital, Heidelberg, Germany; 2Institute of Hygiene, Univ. of Heidelberg, Germany

W868 BK VIRUS IN A PAEDIATRIC RENAL TRANSPLANT POPULATION Leigh Haysom,1 Andrew R. Rosenberg,1 Gad Kainer,1 Zubair Waliuzzaman,2 William Rawlinson,2 Fiona Mackie.1 1Dept of Paediatric Nephrology, Sydney Children’s Hosp., Randwick, NSW, Australia; 2Dept of Virology, Prince of Wales Hosp., Randwick, NSW, Australia

W869 POLYOMA BK VIRUS (BKV)-DNA QUANTIFICATION IN URINE AS A TOOL TO GUIDE PRE-EMPTIVE TREATMENT OF BKV- ASSOCIATED NEPHROPATHY AFTER KIDNEY TRANSPLANTATION Fabrizio Ginevri,1 Riccardo De Santis,2 Patrizia Comoli,3 Gerardo Botti,1 Nadia Pastorino,1 Giancarlo Basile,1 Iris Fontana,4 Francesco Perfumo,1 Alberta Azzi.2 1Pediatric Nephrology Unit, G. Gaslini Institute, Genova, Italy; 2Dept of Public Health, University of Firenze, Firenze, Italy; 3Transplant Immunology and Pediatric Oncology/Hematology Lab, IRCCS Policlinico S. Matteo, Pavia, Italy; 4Dept of Transplantation Surgery, S. Martino Hosp., Genova, Italy

W870 HELICOBACTER PYLORI IN PRETRANSPLANT CHILDREN Ghamar Hashemi,1 M. Imaneih,1 M.R. Khazaee,1 M.H. Fallah Zadeh,1 A. Derakhshan. 1Pediatric Nephrology, Shiraz Univ. of Medical Sciences, Shiraz, Fars, Iran; 2Pediatric Gastroentrology, Shiraz University of Medical Sciences, Shiraz, Fars, Iran; 3Pediatric Nephrology, Shiraz University of Medical Sciences, Shiraz, Fars, Iran; 4Pediatric Nephrology, Shiraz University of Medical Sciences, Shiraz, Fars, Iran; 5Pediatric Nephrology, Shiraz Univ. of Medical Sciences, Shiraz, Fars, Iran

W871 INCREASED EXPRESSION OF INTERCELLULAR ADHESION MOLECULE-1 (ICAM-1) AND KI-67 PROLIFERATION MARKER IN THE ANTRAL MUCOSA OF CHILDREN WITH HELICOBACTER PYLORI INFECTION AFTER KIDNEY TRANSPLANTATION Gabor Veres, Peter Sallay, Antal Dezsofi, Andras Arato, Timea Varga, Tivadar Tulassay, Gyorgy Reusz. Ist Dept. of Paediatrics, Semmelweis University, Budapest, Hungary

W872 POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDERS IN PAEDIATRIC SOLID ORGAN RECIPIENTS: A RETROSPECTIVE ANALYSIS FROM THE MEDICAL SCHOOL HANNOVER FROM 1990 TO 2002 Thomas Jack, Britta Maecker, Anja Lehnhardt, Jochen Ehrich, Karl Welte, Michael Melter, Gisela Offner, Christoph Klein. Childrens Hospital, Hannover Medical School, Hannover, Germany

480 POSTERS WEDNESDAY, JUNE 12

W873 TAILORED CHEMO-IMMUNOTHERAPY TO TREAT EPSTEIN- BARR VIRUS (EBV)-RELATED POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE (PTLD) AFTER KIDNEY TRANSPLANTATION WEDNESDAY Patrizia Comoli,1 Giancarlo Basile,2 Alberto Garaventa,3 Gerardo Botti,2 Claudio Gambini,4 Umberto Valente,5 Angelo Nocera,5 Edoardo Rossi,6 Francesco Perfumo,2 Franco Locatelli,1 Rita Maccario,1 Fabrizio Ginevri.2 1Transplant Immunology Lab and Pediatric Oncology/Hematology, IRCCS Policlinico S. Matteo, Pavia, Italy; 2Pediatric Nephrology Unit, G. Gaslini Institute, Genova, Italy; 3Pediatric Oncology/Hematology Unit, G. Gaslini Institute, Genova, Italy; 4Pathology Service, G. Gaslini Institute, Genova, Italy; 5Transplantation Dept, S. Martino Hosp., Genova, Italy; 6Dept of Hematology, S. Martino Hosp., Genova, Italy

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