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(12) United States Patent (10) Patent No.: US 9,192,648 B2 Hamer Et Al US009 192648B2 (12) United States Patent (10) Patent No.: US 9,192,648 B2 Hamer et al. (45) Date of Patent: Nov. 24, 2015 (54) METHOD OF TREATING MYASTHENIA WO WO-2008/O2.9167 A1 3, 2008 GRAVIS WO WO-2008/029169 A2 3, 2008 WO WO-2009/098454 A2 8, 2009 (75) Inventors: John Hamer, Reading (GB); Wynne Weston-Davies, Reading (GB) OTHER PUBLICATIONS Copland etal. (2010)Systemic and local anti-C5 therapy reduces the (73) Assignee: Volution Immuno Pharmaceuticals SA disease severity in experimental autoimmune uveoretinitis, Clin. (CH) Exp. Immunol., vol. 159, No. 3, pp. 303-314.* Piddlesden et al. (1996) Soluble complement receptor 1 (SCR1) (*) Notice: Subject to any disclaimer, the term of this protects against experimental autoimmune myasthenia gravis, J. patent is extended or adjusted under 35 Neuroimmunol., vol. 71, No. 1-2, pp. 173-177.* U.S.C. 154(b) by 1397 days. Hsu et al. 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A61K 38/17 (2013.01) Hepburn et al., “Prevention of experimental autoimmune myasthenia (58) Field of Classification Search gravis by rat Crry-Ig: A model agent for long-term complement CPC ............................................... C12N2O15/8563 inhibition in vivo”. Molecular Immunology, 2008, 45, 395-405. See application file for complete search history. Nunnet al., “Complement inhibitor of C5activation from the soft tick Ornithodorus moubata'. The Journal of Immunology, 2005, 174. 2084-2091. (56) References Cited Richman et al., “Antibody effector mechanisms in myasthenia gravis U.S. PATENT DOCUMENTS The complement hypothesis'. Annals of the New York Academy of Sciences, 1998, 450-465. 5,041,389 A * 8, 1991 Lindstrom .................... 436,518 5,858,969 A * 1/1999 Marsh et al. ... 514/15 (Continued) 6,103,748 A * 8/2000 Bryan ........................... 514,400 7,884,066 B2 2/2011 Ting 7,884,069 B2 2/2011 Schaebitz et al. Primary Examiner — Manjunath Rao 2004/0014782 A1 1/2004 Krause .......................... 514/313 Assistant Examiner — Samuel Liu 2007/0048248 A1 3f2007 Benedict et al. ............. 424/78.3 2007/O141573 A1 6, 2007 Nunn (74) Attorney, Agent, or Firm — Choate, Hall & Stewart 2008.0114055 A1 5/2008 Kiss .............................. 514,437 LLP, Fangli Chen; Stephanie L. Schonewald 2008/O199484 A1* 8, 2008 Yu et al. ..................... 424,184.1 2010, O105611 A1 4/2010 Hamer 2011/0059885 A1 3/2011 Lea et al. (57) ABSTRACT FOREIGN PATENT DOCUMENTS The invention relates to the use of agents that bind the complement protein C5 in the treatment of diseases associ WO WO-93/17099 A1 9, 1993 WO WO2004 106369 A2 * 12/2004 ated with inappropriate complement activation, and in par WO 2005O23866 3, 2005 ticular in the treatment of myasthenia gravis. 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