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Thomas E. Starzl Selected for Prestigious National Award

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Thomas E. Starzl Selected for Prestigious National Award INSIDE Pitt honors its scholar-athletes.............. 4 Pitt-led researchers make quick test for TB...... 8 PittNewspaper of the University of PittsburghChronicle Volume X • Number 10 • March 23, 2009 Pitt Gets $4.7 Million Grant to Reduce Hospital-acquired Infections By Clare Collins The University of Pittsburgh School to prevent and control hospital-acquired of Medicine has received a four-year, infections, which were diagnosed in 27,000 $4.7 million grant from the Pennsylvania patients in Pennsylvania in 2007. Patients Department of Health to find new ways to with these infections were hospitalized stop deadly hospital-acquired infections three times longer, and their admissions that often are resistant to treatment. The were four times as expensive as those of grant, funded by Pennsylvania’s share of noninfected patients. the national 2008-09 tobacco settlement, Most bacterial infections can be will focus on C. difficile, A. bau- effectively controlled with existing mannii, and the drug-resistant antibiotic drugs, but microbial bacteria known as MRSA, pathogens like C. difficile, A. which cause tens of thou- baumannii, and MRSA have sands of deaths in the U.S. an inherent ability to develop every year. drug resistance through “Infections that are many genetic mechanisms, resistant to antibiotics are making them particularly becoming increasingly difficult to treat. problematic not only in the Pitt School of Medicine United States, but around coinvestigators on the grant the world,” said Lee Harrison, include Scott Curry, clinical principal investigator of the grant assistant professor in the Division and professor of medicine and epi- Lee Harrison of Infectious Diseases; Jo-Anne demiology, University of Pittsburgh. “We Salangsang, a fellow in the Department of not only need to develop new drugs, but Infectious Diseases; Yohei Doi, an assis- also to improve infection surveillance and tant professor of medicine; Bruce Lee, an focus on targeted interventions.” assistant professor of medicine; and Paula The grant will enable investigators to Davis, assistant vice chancellor for diversity, establish a Center of Excellence in Preven- schools of the health sciences. tion and Control of Antibiotic-Resistant The grant was awarded as part of Bacterial Infections at Pitt, and it will the Commonwealth Universal Research Pitt Tests Vaccine to include partnerships with several UPMC Enhancement Program, which supports hospitals, Carnegie Mellon University, clinical, health services, and biomedical and Kane Regional Centers of Allegheny research, and was one of only four awarded County. to address the Pennsylvania 2008-09 Health Prevent Colon Cancer The project will assess the medical Research Advisory Committee’s priori- By Anita Srikameswaran and economic impacts of new strategies ties. Researchers at the University of work via a different mechanism, spe- Pittsburgh School of Medicine cifically by blocking infection have begun testing a vac- with viruses that are linked with cine that might be able to cancer. For example, Garda- Thomas E. Starzl Selected for prevent colon cancer in sil protects against human people at high risk for papilloma virus associated developing the disease. If with cervical cancer, and Prestigious National Award shown to be effective, it hepatitis B vaccine pro- might spare patients the tects against liver cancer. By Megan Grote Quatrini risk and inconvenience “By stimulating an of repeated invasive sur- immune response against University of Pittsburgh transplant “I am deeply honored to receive this veillance tests, such as the MUC1 protein in these pioneer Thomas E. Starzl, known as the award, not as an individual, but rather as a colonoscopy, that are now precancerous growths, father of transplantation, has been selected representative of the outstanding transplan- necessary to spot and remove we may be able to draw the by Castle Connolly Medical Ltd. to receive a tation team,” said Starzl. “From the begin- precancerous polyps. immune system’s fire to attack Physician of the Year Award ning, our team included all Colon cancer takes years to Robert E. Schoen and destroy the abnormal cells,” for Lifetime Achievement. components of the Univer- develop and typically Schoen said. “That The prestigious award sity of Pittsburgh, from the starts with a polyp, might not only prevent honors a select group of schools of the health sci- which is a benign but Colorectal cancer is the progression to cancer, physicians who have made ences to the consortium of abnormal growth in third-leading cause of cancer but even polyp recur- notable contributions to the affiliated UPMC hospitals. the intestinal lining, rence.” field of medicine. Honorees I’m proud to have been a explained principal death in the United States. In According to are selected from more than part of this team, which has investigator Robert E. coinvestigator Olivera 600,000 physicians cur- worked tirelessly to advance Schoen, professor of 2008, the American Cancer Finn, professor and rently practicing medicine the field of organ transplan- medicine and epidemi- chair in the Depart- in the United States. An tation and provide hope ology in the University Society estimated that there ment of Immunology award ceremony will be to countless patients who of Pittsburgh School of in Pitt’s School of held in New York City on otherwise had none.” Medicine and Gradu- were more than 108,000 Medicine, MUC1 vac- March 23. Retired from clinical ate School of Public new cases of colon cancer, cines have been tested Starzl is a Distinguished and surgical service since Health, respectively. for safety and immu- Service Professor of Sur- Thomas E. Starzl 1991, Starzl still remains Poly ps that could nearly 41,000 cases of rectal nogenicity in patients gery in the University of Pittsburgh active in research, mapping the become cancerous are with late-stage colon School of Medicine and director emeritus of relationship between donor and recipient called adenomas. cancer, and almost 50,000 cancer and pancreatic the Thomas E. Starzl Transplantation Insti- cells and developing new therapeutic strat- I n a n o v e l cancer. tute at the University of Pittsburgh Medical egies to achieve immune tolerance after approach to cancer deaths owing to both “Patients were Center (UPMC). He achieved international transplantation. prevention, the Pitt able to generate an acclaim by laying the groundwork for the Castle Connolly Medical Ltd. is a vaccine is directed diseases. im mune response transplantation field of medicine. Today, the national health care research and infor- against an abnormal despite their cancer- Thomas E. Starzl Transplantation Institute mation company established in 1991 by variant of a self-made cell protein called weakened immune systems,” she noted. remains the world leader in transplantation a former medical college board chair MUC1, which is altered and produced in “Patients with advanced adenomas are oth- experience, with more than 10,000 patients and president. The company publishes excess in advanced adenomas and cancer. treated to date. the annual guide America’s Top Doctors. Vaccines currently in use to prevent cancer Continued on page 2 2 • Pitt Chronicle • March 23, 2009 Pitt Tests Vaccine BrieflyNoted To Prevent Colon Cancer Continued from page 1 Pitt’s University Club to Hold Pitt Dance Ensemble to Perform in About a dozen people have Open Houses for Faculty, Staff “Disengaged” received the experimental vaccine The University of Pittsburgh’s University Club The University of Pittsburgh Dance Ensemble will so far, and the researchers intend will offer Pitt faculty and staff a sneak preview of the present “Disengaged”—a formal dance concert with club’s newly renovated facilities through a series of choreography by students and professional guests featuring to enroll another 50 or so in the open house tours. The time and dates of the tours, ballet, jazz, tap, and modern styles of dance—at study. which will showcase the publicly accessible banquet 8:15 p.m. March 26, 27, and 28 in the Trees Hall Dance and conference centers, as well as the members-only Studio. faculty and staff club, follow: This year’s guest choreographers include Michelle erwise healthy, so they would be expected to Wednesday, March 25, 9 a.m.-1 p.m.; Hall Dawson, a former dancer with the Dance Alloy Theater generate a stronger immune response. That Friday, March 27, noon- 4 p.m.; and in Pittsburgh, and Greer Reed-Jones, the education director may be able to stop precancerous lesions Monday, March 30, 3-6 p.m. for the Dance Alloy Theater. from transforming into malignant tumors.” Dawson’s piece, titled “In the Station,” is set to About a dozen people have received In addition to more than 18,000 square feet the experimental vaccine so far, and the of conference and banquet space, the club will also Beethoven’s “Moonlight” Sonata and features seven of the researchers intend to enroll another 50 or so offer such amenities as first-class dining facilities, ensemble’s dancers. According to Dawson, “In the Station” in the study. Participants must be between 40 a state-of-the-art fitness center, a College Room depicts “the passing of love and time and the eternity of Alan Hall and 70 years old and have a history of devel- lounge, a library with wireless Internet, and special waiting, knowing that personal loss and grief can arrive in oping adenomas that are deemed advanced, events on the Rooftop Terrace, which provides a view some unexpected ways.” This work also was performed meaning they are greater than or equal to 1 of Oakland. earlier this month at the American College Dance Festival at Cell Biologist Alan Hall to centimeter in size, are typed as villous or The University Club, located in a historic Pennsylvania State University. Launch Medical School Lecture tubulovillous, or contain severely dysplastic, building at 123 University Place that was designed In a strikingly different dance style, Reed-Jones’ Series or abnormal, cells.
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