RESEARCH ADVANCE Boosts in brain signal variability track liberal shifts in decision bias Niels A Kloosterman1,2*, Julian Q Kosciessa1,2, Ulman Lindenberger1,2, Johannes Jacobus Fahrenfort3,4, Douglas D Garrett1,2* 1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; 2Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; 3Department of Experimental and Applied Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands; 4Department of Psychology, University of Amsterdam, Amsterdam, Netherlands Abstract Adopting particular decision biases allows organisms to tailor their choices to environmental demands. For example, a liberal response strategy pays off when target detection is crucial, whereas a conservative strategy is optimal for avoiding false alarms. Using conventional time-frequency analysis of human electroencephalographic (EEG) activity, we previously showed that bias setting entails adjustment of evidence accumulation in sensory regions (Kloosterman et al., 2019), but the presumed prefrontal signature of a conservative-to-liberal bias shift has remained elusive. Here, we show that a liberal bias shift is reflected in a more unconstrained neural regime (boosted entropy) in frontal regions that is suited to the detection of unpredictable events. Overall EEG variation, spectral power and event-related potentials could not explain this relationship, highlighting that moment-to-moment neural variability uniquely tracks bias shifts. Neural variability modulation through prefrontal cortex appears instrumental for permitting an organism to adapt its biases to environmental demands. *For correspondence:
[email protected] (NAK);
[email protected] (DDG) Introduction We often reach decisions not only by objectively weighing different alternatives, but also by allowing Competing interests: The subjective biases to influence our choices.